Phenominer Database Results (556 results)

 
 
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Strain Phenotype Conditions Study Experiment Name Sex Age # of Animals Formula Value Units SEM SD Method Method Site Method Duration Post Insult Type Post Insult Time Value Post Insult Time Unit Method Notes Clinical Measurement Notes Experiment Notes Record ID Study ID
BN/CrlCrlj blood glucose level controlled protein content diet (for 120 days) then fasting (for 9 hours) then glucose solution Tsuji A, et al., Genomics 2001 Jun 15;74(3):365-9. blood glucose amount male 120 days 5 178.1 mg/dl 7.9 17.66 oral glucose tolerance test glucose challenge 30 min glucose dose not specified serum glucose WBN/Kob rats were studied as a model of pancreatitis and diabetes mellitus 12908 321
BN/CrlCrlj blood glucose level controlled protein content diet (for 120 days) then fasting (for 9 hours) then glucose solution Tsuji A, et al., Genomics 2001 Jun 15;74(3):365-9. blood glucose amount male 120 days 5 211.3 mg/dl 17.9 40.03 oral glucose tolerance test glucose challenge 60 min glucose dose not specified serum glucose WBN/Kob rats were studied as a model of pancreatitis and diabetes mellitus 12909 321
SS/HsdMcwiCrl epididymal fat pad weight to tibia length ratio controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. epididymal fat pad mass male 112 days 9 1.33 g/cm 0.07 0.21 post excision weight measurement 0.0 0 67653 735
SS/HsdMcwiCrl food intake rate controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. eating behavior trait male 112 days 8 25.2 g/d 1.3 3.68 unspecified method 0.0 0 67659 735
SS/HsdMcwiCrl urine sodium excretion rate controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. urine sodium amount male 112 days 9 6.4 mEq/d 0.4 1.2 automated urine analysis 0.0 0 67668 735
SS/HsdMcwiCrl sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then phenylephrine (2 umol/l) then sodium nitroprusside (0.316 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasodilation trait male 112 days 10 [(maximum PE response − SNP response)/(maximum PE response − baseline before PE constriction)] × 100 96.65 % 1.91 6.04 wire myography mesenteric artery 0.0 0 BCA assay 67672 735
WBN/KobSlc percentage of study population developing chronic pancreatitis during a period of time controlled protein content diet Tsuji A, et al., Genomics 2001 Jun 15;74(3):365-9. pancreas integrity trait male 120 days 5 100.0 % ex vivo light microscopy 0.0 0 67774 321
WBN/KobSlc percentage of study population developing chronic pancreatitis during a period of time controlled protein content diet Tsuji A, et al., Genomics 2001 Jun 15;74(3):365-9. pancreas integrity trait male 150 days 5 100.0 % ex vivo light microscopy 0.0 0 67775 321
F344/NRrrc ratio of apoptotic bodies to intact tumor cells in nonremodelling liver tumorous lesions N-nitrosodiethylamine (150 mg/kg) then controlled protein content diet (for 15 days) and controlled 2-acetamidofluorene content diet (0.02 %) then partial hepatectomy De Miglio MR, et al., Int J Cancer 2003 May 20;105(1):70-5. liver integrity trait not specified 0 days 5 1.25 % 0.05 0.11 ex vivo light microscopy with immunohistochemistry and digital image analysis 0.0 0 84785 1603
SS/HsdMcwiCrl logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then phenylephrine (2 umol/l) then NG-nitroarginine methyl ester (100 umol/l) then acetylcholine (0.001-9.5 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasodilation trait male 112 days 6 logEC50 -6.6 null 0.1 0.24 wire myography mesenteric artery 0.0 0 84646 735
PXO4/Cub body weight controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. body mass male 127 days 9 300.1 g 5.1 15.3 body weighing method 0.0 0 97169 1858
PXO3-1/Cub blood chylomicron triglyceride level controlled sucrose content diet (70 % of calories) (for 7 days) and controlled protein content diet (19.6 % of calories) (for 7 days) and controlled fat content diet (10.4 % of calories) (for 7 days) then fasting (for 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood chylomicron triglyceride amount male 127 days 10 0.29 mg/dl 0.02 0.06 enzymatic triglyceride assay 0.0 0 97583 1858
PXO2/Cub blood chylomicron triglyceride level controlled sucrose content diet (70 % of calories) (for 7 days) and controlled protein content diet (19.6 % of calories) (for 7 days) and controlled fat content diet (10.4 % of calories) (for 7 days) then fasting (for 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood chylomicron triglyceride amount male 127 days 11 0.98 mg/dl 0.19 0.63 enzymatic triglyceride assay 0.0 0 97592 1858
PXO8-1/Cub blood very low density lipoprotein triglyceride level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood VLDL triglyceride amount male 127 days 10 28.6 mg/dl 2.6 8.22 enzymatic triglyceride assay 0.0 0 97613 1858
SHR-Ndufc2em1Mcwi-/+ body weight controlled protein content diet (19.7 %) (for 28 days) and controlled potassium content diet (6.3 mg/g) (for 28 days) and controlled sodium content diet (3.7 mg/g) (for 28 days) Rubattu S, et al., J Am Heart Assoc. 2016 Feb 17;5(2). pii: e002701. doi: 10.1161/JAHA.115.002701. body mass not specified 70 days 17 235.0 g 3.4 14.0 body weighing method 0.0 0 97899 1938
SHR-Ndufc2em2Mcwi+/+ body weight controlled protein content diet (19.7 %) (for 28 days) and controlled potassium content diet (6.3 mg/g) (for 28 days) and controlled sodium content diet (3.7 mg/g) (for 28 days) Rubattu S, et al., J Am Heart Assoc. 2016 Feb 17;5(2). pii: e002701. doi: 10.1161/JAHA.115.002701. body mass not specified 70 days 12 239.0 g 3.75 13.0 body weighing method 0.0 0 97900 1938
SHR-Ndufc2em2Mcwi+/+ body weight controlled protein content diet (19.7 %) (for 84 days) and controlled potassium content diet (6.3 mg/g) (for 84 days) and controlled sodium content diet (3.7 mg/g) (for 84 days) Rubattu S, et al., J Am Heart Assoc. 2016 Feb 17;5(2). pii: e002701. doi: 10.1161/JAHA.115.002701. body mass not specified 126 days 12 314.0 g 14.15 49.0 body weighing method 0.0 0 97902 1938
SHR-Ndufc2em2Mcwi-/+ body weight controlled protein content diet (19.7 %) (for 28 days) and controlled potassium content diet (6.3 mg/g) (for 28 days) and controlled sodium content diet (3.7 mg/g) (for 28 days) Rubattu S, et al., J Am Heart Assoc. 2016 Feb 17;5(2). pii: e002701. doi: 10.1161/JAHA.115.002701. body mass not specified 70 days 26 237.0 g 5.3 27.0 body weighing method 0.0 0 97903 1938
SHRSP/Bbb body weight controlled protein content diet (19.7 %) (for 49 days) and controlled potassium content diet (6.3 mg/g) (for 49 days) and controlled sodium content diet (3.7 mg/g) (for 49 days) Rubattu S, et al., J Am Heart Assoc. 2016 Feb 17;5(2). pii: e002701. doi: 10.1161/JAHA.115.002701. body mass not specified 91 days 5 192.0 g 2.68 6.0 body weighing method 0.0 0 97910 1938
PXO4/Cub blood glycerol level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood glycerol amount male 127 days 9 3.84 mg/dl 0.19 0.57 enzymatic triglyceride assay 0.0 0 97564 1858
PXO7-1/Cub blood glycerol level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood glycerol amount male 127 days 8 4.08 mg/dl 0.11 0.31 enzymatic triglyceride assay 0.0 0 97566 1858
PXO6-2/Cub retroperitoneal fat pad weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. retroperitoneal fat pad mass male 127 days 8 0.41 % 0.04 0.11 post excision weight measurement 0.0 0 97778 1858
PXO9/Cub retroperitoneal fat pad weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. retroperitoneal fat pad mass male 127 days 9 0.61 % 0.03 0.09 post excision weight measurement 0.0 0 97782 1858
PXO8-2/Cub retroperitoneal fat pad weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. retroperitoneal fat pad mass male 127 days 13 0.87 % 0.03 0.11 post excision weight measurement 0.0 0 97787 1858
SS/HsdMcwiCrl acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then phenylephrine (1 umol/l) then NG-nitroarginine methyl ester (100 umol/l) then acetylcholine (31.6 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasodilation trait male 112 days 6 [(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] × 100 -16.62 % 7.27 17.81 wire myography aorta 0.0 0 84659 735
SS/HsdMcwiCrl logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then phenylephrine (1 umol/l) then acetylcholine (0-95 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasodilation trait male 112 days 4 logEC50 -6.31 null 0.1 0.2 wire myography aorta 0.0 0 logEC50 84664 735
SS/HsdMcwiCrl logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then phenylephrine (1 umol/l) then acetylcholine (0.001-95 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasodilation trait male 112 days 5 logEC50 -6.49 null 0.09 0.2 wire myography aorta 0.0 0 84667 735
SS/HsdMcwiCrl logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then phenylephrine (1 umol/l) then sodium nitroprusside (0-9.5 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasodilation trait male 112 days 10 logEC50 -7.93 null 0.15 0.47 wire myography aorta 0.0 0 84669 735
PXO3-2/Cub blood glycerol level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood glycerol amount male 127 days 9 3.4 mg/dl 0.15 0.45 enzymatic triglyceride assay 0.0 0 97562 1858
PXO7-1/Cub blood very low density lipoprotein triglyceride level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood VLDL triglyceride amount male 127 days 8 27.7 mg/dl 3.1 8.77 enzymatic triglyceride assay 0.0 0 97612 1858
SHR.BN-(D8Mit5-D8Mgh6)/Ipcv both testes wet weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. testis mass male 127 days 13 0.97 % 0.01 0.04 post excision weight measurement 0.0 0 97500 1858
PXO3-1/Cub epididymal fat pad weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. epididymal fat pad mass male 127 days 10 1.09 % 0.03 0.09 post excision weight measurement 0.0 0 97525 1858
SHR.BN-(D8Mit5-D8Mgh6)/Ipcv blood chylomicron triglyceride level controlled sucrose content diet (70 % of calories) (for 7 days) and controlled protein content diet (19.6 % of calories) (for 7 days) and controlled fat content diet (10.4 % of calories) (for 7 days) then fasting (for 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood chylomicron triglyceride amount male 127 days 13 0.53 mg/dl 0.08 0.29 enzymatic triglyceride assay 0.0 0 97587 1858
PXO8-2/Cub epididymal fat pad weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. epididymal fat pad mass male 127 days 13 1.24 % 0.03 0.11 post excision weight measurement 0.0 0 97526 1858
PXO2/Cub blood total cholesterol level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood cholesterol amount male 127 days 11 74.1 mg/dl 1.8 5.97 enzymatic cholesterol assay 0.0 0 97226 1858
PXO7-1/Cub blood total cholesterol level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood cholesterol amount male 127 days 8 51.7 mg/dl 1.0 2.83 enzymatic cholesterol assay 0.0 0 97213 1858
SHR.BN-(D8Mit5-D8Mgh6)/Ipcv heart weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. heart mass male 127 days 13 4.1 g/kg 0.2 0.72 post excision weight measurement 0.0 0 97105 1858
PXO9/Cub blood low density lipoprotein cholesterol level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood LDL cholesterol amount male 127 days 9 20.88 mg/dl 1.08 3.24 enzymatic cholesterol assay 0.0 0 change to mg/dl when available 97293 1858
PXO9/Cub both adrenal glands weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. adrenal gland mass male 127 days 9 13.0 mg/100g 1.0 3.0 post excision weight measurement 0.0 0 97391 1858
PXO3-1/Cub both adrenal glands weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. adrenal gland mass male 127 days 10 14.0 mg/100g 0.5 1.58 post excision weight measurement 0.0 0 97393 1858
PXO3-1/Cub blood chylomicron cholesterol level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood chylomicron cholesterol amount male 127 days 10 0.03 mg/dl 0.0 0.01 enzymatic cholesterol assay 0.0 0 97349 1858
PXO8-1/Cub blood chylomicron cholesterol level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood chylomicron cholesterol amount male 127 days 10 0.06 mg/dl 0.01 0.03 enzymatic cholesterol assay 0.0 0 97352 1858
PXO5-1/Cub blood chylomicron cholesterol level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood chylomicron cholesterol amount male 127 days 11 0.16 mg/dl 0.04 0.13 enzymatic cholesterol assay 0.0 0 97357 1858
PXO6-2/Cub body weight controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. body mass male 127 days 8 278.6 g 5.2 14.71 body weighing method 0.0 0 97165 1858
PXO6-1/Cub blood high density lipoprotein cholesterol level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood HDL cholesterol amount male 127 days 10 31.15 mg/dl 1.38 4.36 enzymatic cholesterol assay 0.0 0 97301 1858
PXO6-3/Cub blood high density lipoprotein cholesterol level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood HDL cholesterol amount male 127 days 10 43.66 mg/dl 1.74 5.5 enzymatic cholesterol assay 0.0 0 97308 1858
PXO8-1/Cub both adrenal glands weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. adrenal gland mass male 127 days 10 15.0 mg/100g 0.8 2.53 post excision weight measurement 0.0 0 97398 1858
PXO5-2/Cub both adrenal glands weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. adrenal gland mass male 127 days 10 19.0 mg/100g 0.4 1.26 post excision weight measurement 0.0 0 97406 1858
PXO6-2/Cub liver weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. liver mass male 127 days 8 23.7 g/kg 0.3 0.85 post excision weight measurement 0.0 0 97195 1858
PXO2/Cub liver weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. liver mass male 127 days 11 24.8 g/kg 0.3 0.99 post excision weight measurement 0.0 0 97197 1858
PXO6-3/Cub blood glycerol level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood glycerol amount male 127 days 10 4.65 mg/dl 0.19 0.6 enzymatic triglyceride assay 0.0 0 97572 1858
PXO10/Cub blood glycerol level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood glycerol amount male 127 days 12 5.1 mg/dl 0.13 0.45 enzymatic triglyceride assay 0.0 0 97574 1858
SHR-Ndufc2em1Mcwi-/+ systolic blood pressure controlled protein content diet (19.7 %) (for 56 days) and controlled potassium content diet (6.3 mg/g) (for 56 days) and controlled sodium content diet (3.7 mg/g) (for 56 days) Rubattu S, et al., J Am Heart Assoc. 2016 Feb 17;5(2). pii: e002701. doi: 10.1161/JAHA.115.002701. arterial blood pressure trait not specified 98 days 17 undefined 178.0 mmHg 1.46 6.0 tail cuff plethysmography 0.0 0 97920 1938
SHR-Ndufc2em2Mcwi-/+ systolic blood pressure controlled protein content diet (19.7 %) (for 28 days) and controlled potassium content diet (6.3 mg/g) (for 28 days) and controlled sodium content diet (3.7 mg/g) (for 28 days) Rubattu S, et al., J Am Heart Assoc. 2016 Feb 17;5(2). pii: e002701. doi: 10.1161/JAHA.115.002701. arterial blood pressure trait not specified 70 days 26 undefined 177.0 mmHg 1.37 7.0 tail cuff plethysmography 0.0 0 97925 1938
SHR/Bbb urine total protein excretion rate controlled protein content diet (19.7 %) (for 28 days) and controlled potassium content diet (6.3 mg/g) (for 28 days) and controlled sodium content diet (3.7 mg/g) (for 28 days) Rubattu S, et al., J Am Heart Assoc. 2016 Feb 17;5(2). pii: e002701. doi: 10.1161/JAHA.115.002701. total urine protein amount not specified 70 days 18 33.0 mg/d 1.3 5.5 urine analysis 0.0 0 97928 1938
PXO1/Cub liver weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. liver mass male 127 days 11 26.2 g/kg 0.2 0.66 post excision weight measurement 0.0 0 97205 1858
PXO9/Cub both testes wet weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. testis mass male 127 days 9 1.11 % 0.02 0.06 post excision weight measurement 0.0 0 97508 1858
PXO1/Cub both testes wet weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. testis mass male 127 days 11 1.12 % 0.02 0.07 post excision weight measurement 0.0 0 97509 1858
PXO3-2/Cub epididymal fat pad weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. epididymal fat pad mass male 127 days 9 0.88 % 0.02 0.06 post excision weight measurement 0.0 0 97517 1858
PXO6-3/Cub epididymal fat pad weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. epididymal fat pad mass male 127 days 10 0.89 % 0.02 0.06 post excision weight measurement 0.0 0 97519 1858
PXO5-1/Cub blood low density lipoprotein cholesterol level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood LDL cholesterol amount male 127 days 11 10.45 mg/dl 1.44 4.78 enzymatic cholesterol assay 0.0 0 change to mg/dl when available 97281 1858
PXO3-2/Cub blood low density lipoprotein cholesterol level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood LDL cholesterol amount male 127 days 9 10.72 mg/dl 0.65 1.95 enzymatic cholesterol assay 0.0 0 change to mg/dl when available 97282 1858
SHR.BN-(D8Mit5-D8Mgh6)/Ipcv blood low density lipoprotein cholesterol level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood LDL cholesterol amount male 127 days 13 21.56 mg/dl 0.61 2.2 enzymatic cholesterol assay 0.0 0 change to mg/dl when available 97294 1858
PXO4/Cub blood triglyceride level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood triglyceride amount male 127 days 9 53.6 mg/dl 4.3 12.9 enzymatic triglyceride assay 0.0 0 97327 1858
PXO3-1/Cub blood high density lipoprotein triglyceride level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood HDL triglyceride amount male 127 days 10 2.58 mg/dl 0.1 0.32 enzymatic triglyceride assay 0.0 0 97634 1858
SHR.BN-(D8Mit5-D8Mgh6)/Ipcv blood high density lipoprotein triglyceride level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood HDL triglyceride amount male 127 days 13 3.31 mg/dl 0.14 0.5 enzymatic triglyceride assay 0.0 0 97640 1858
PXO4/Cub blood very low density lipoprotein cholesterol level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood VLDL cholesterol amount male 127 days 9 3.43 mg/dl 0.4 1.2 enzymatic cholesterol assay 0.0 0 change to mg/dl when available 97265 1858
PXO3-2/Cub blood very low density lipoprotein triglyceride level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood VLDL triglyceride amount male 127 days 9 18.5 mg/dl 3.1 9.3 enzymatic triglyceride assay 0.0 0 97608 1858
PXO6-3/Cub blood low density lipoprotein particle diameter controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood LDL particle size male 127 days 10 20.77 nm 0.17 0.54 high-performance liquid chromatography 0.0 0 97679 1858
PXO9/Cub blood high density lipoprotein particle diameter controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood HDL particle size male 127 days 9 12.84 nm 0.05 0.15 high-performance liquid chromatography 0.0 0 97707 1858
PXO6-3/Cub heart weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. heart mass male 127 days 10 3.2 g/kg 0.0 0.0 post excision weight measurement 0.0 0 97181 1858
PXO9/Cub heart weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. heart mass male 127 days 9 4.0 g/kg 0.1 0.3 post excision weight measurement 0.0 0 97192 1858
PXO6-1/Cub both kidneys wet weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. kidney mass male 127 days 10 6.0 g/kg 0.1 0.32 post excision weight measurement 0.0 0 97151 1858
PXO3-1/Cub both kidneys wet weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. kidney mass male 127 days 10 6.3 g/kg 0.1 0.32 post excision weight measurement 0.0 0 97154 1858
PXO4/Cub liver weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. liver mass male 127 days 9 26.0 g/kg 0.3 0.9 post excision weight measurement 0.0 0 97202 1858
PXO10/Cub blood very low density lipoprotein cholesterol level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood VLDL cholesterol amount male 127 days 12 7.8 mg/dl 0.44 1.52 enzymatic cholesterol assay 0.0 0 change to mg/dl when available 97274 1858
SHRSP/A3NCrl partial pressure of brain white matter oxygen right carotid artery occlusion then controlled protein content diet (16 %) (for 21 days) and controlled sodium content diet (4 %) (for 21 days) and controlled potassium content diet (0.75 %) (for 21 days) and controlled sodium chloride content drinking water (1 %) (for 21 days) Weaver J, etal., J Cereb Blood Flow Metab. 2014 May;34(5):890-6. doi: 10.1038/jcbfm.2014.35. Epub 2014 Feb 19. brain oxygen amount male 105 days 17 14.9 mmHg 1.2 4.95 electron paramagnetic resonance oximetry white matter 40.0 0 5 scans x 40 seconds 107327 3080
SHRSP/A3NCrl brain infarction volume controlled protein content diet (16 %) (for 63 days) and controlled sodium content diet (4 %) (for 63 days) and controlled potassium content diet (0.75 %) (for 63 days) and unilateral carotid artery occlusion (for 63 days) then dimethyl sulfoxide (30 %) (for 63 days) and Kolliphor HS 15 (25 %) (for 0 hours) Yang Y, etal., Neurobiol Dis. 2018 Jun;114:95-110. doi: 10.1016/j.nbd.2018.02.012. Epub 2018 Feb 24. brain integrity trait male 147 days 8 53.0 mm3 7.4 20.93 magnetic resonance imaging corpus callosum 0.0 0 corpus callosum-right hemisphere corpus callosum-right hemisphere 107287 3079
SHRSP/A3NCrl partial pressure of brain white matter oxygen right carotid artery occlusion then controlled protein content diet (16 %) and controlled sodium content diet (4 %) and controlled potassium content diet (0.75 %) and controlled sodium chloride content drinking water (1 %) Weaver J, etal., J Cereb Blood Flow Metab. 2014 May;34(5):890-6. doi: 10.1038/jcbfm.2014.35. Epub 2014 Feb 19. brain oxygen amount male 84 days 17 37.1 mmHg 1.2 4.95 electron paramagnetic resonance oximetry white matter 40.0 0 5 scans x 40 seconds vascular cognitive impairment 107321 3080
SS/HsdMcwiCrl logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then phenylephrine (2 umol/l) then acetylcholine (0.001-9.5 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasodilation trait male 112 days 6 logEC50 -7.2 null 0.1 0.24 wire myography mesenteric artery 0.0 0 84642 735
SS/HsdMcwiCrl logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) then phenylephrine (2 umol/l) then sodium nitroprusside (0.316 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasodilation trait male 112 days 7 logEC50 -7.9 null 0.12 0.32 wire myography mesenteric artery 0.0 0 BCA assay 84648 735
PXO1/Cub blood chylomicron cholesterol level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood chylomicron cholesterol amount male 127 days 11 0.13 mg/dl 0.02 0.07 enzymatic cholesterol assay 0.0 0 97356 1858
PXO9/Cub blood high density lipoprotein cholesterol level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood HDL cholesterol amount male 127 days 9 32.9 mg/dl 2.96 8.88 enzymatic cholesterol assay 0.0 0 97303 1858
PXO6-3/Cub blood triglyceride level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood triglyceride amount male 127 days 10 35.3 mg/dl 1.2 3.79 enzymatic triglyceride assay 0.0 0 97320 1858
BXH2/Cub blood low density lipoprotein cholesterol level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood LDL cholesterol amount male 127 days 18 15.68 mg/dl 1.08 4.58 enzymatic cholesterol assay 0.0 0 change to mg/dl when available 97289 1858
PXO2/Cub both adrenal glands weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. adrenal gland mass male 127 days 11 12.0 mg/100g 1.3 4.31 post excision weight measurement 0.0 0 97389 1858
PXO6-1/Cub blood very low density lipoprotein triglyceride level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood VLDL triglyceride amount male 127 days 10 5.6 mg/dl 0.6 1.9 enzymatic triglyceride assay 0.0 0 97600 1858
PXO7-1/Cub blood very low density lipoprotein cholesterol level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood VLDL cholesterol amount male 127 days 8 2.91 mg/dl 0.25 0.71 enzymatic cholesterol assay 0.0 0 change to mg/dl when available 97264 1858
PXO10/Cub epididymal fat pad weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. epididymal fat pad mass male 127 days 12 0.8 % 0.02 0.07 post excision weight measurement 0.0 0 97342 1858
PXO4/Cub blood chylomicron triglyceride level controlled sucrose content diet (70 % of calories) (for 7 days) and controlled protein content diet (19.6 % of calories) (for 7 days) and controlled fat content diet (10.4 % of calories) (for 7 days) then fasting (for 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood chylomicron triglyceride amount male 127 days 9 0.37 mg/dl 0.1 0.3 enzymatic triglyceride assay 0.0 0 97585 1858
BXH2/Cub blood low density lipoprotein particle diameter controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood LDL particle size male 127 days 18 21.82 nm 0.13 0.55 high-performance liquid chromatography 0.0 0 97691 1858
PXO6-1/Cub heart weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. heart mass male 127 days 10 4.1 g/kg 0.2 0.63 post excision weight measurement 0.0 0 97193 1858
PXO8-2/Cub blood low density lipoprotein particle diameter controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood LDL particle size male 127 days 13 20.81 nm 0.05 0.18 high-performance liquid chromatography 0.0 0 97680 1858
PXO3-2/Cub both kidneys wet weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. kidney mass male 127 days 9 6.0 g/kg 0.1 0.3 post excision weight measurement 0.0 0 97152 1858
PXO6-3/Cub liver weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. liver mass male 127 days 10 26.1 g/kg 0.4 1.26 post excision weight measurement 0.0 0 97203 1858
WBN/KobSlc serum insulin level controlled protein content diet (for 120 days) then fasting (for 9 hours) Tsuji A, et al., Genomics 2001 Jun 15;74(3):365-9. blood insulin amount male 120 days 5 0.0 mg/dl 0.0 0.0 oral glucose tolerance test glucose challenge 0 min serum glucose 12900 321
BN/CrlCrlj serum insulin level controlled protein content diet (for 120 days) then fasting (for 9 hours) then glucose solution Tsuji A, et al., Genomics 2001 Jun 15;74(3):365-9. blood insulin amount male 120 days 5 0.0 mg/dl 0.0 0.0 oral glucose tolerance test glucose challenge 30 min glucose dose not specified serum glucose 12912 321
SS/HsdMcwiCrl body weight to tibia length ratio controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. body mass male 112 days 6 96.12 g/cm 1.28 3.14 body weighing method 0.0 0 67616 735
SS/HsdMcwiCrl heart weight to tibia length ratio controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) then controlled protein content diet (19 %) (for 91 days) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. heart mass male 112 days 6 0.31 g/cm 0.01 0.02 post excision weight measurement 0.0 0 67620 735
SS/HsdMcwiCrl both kidneys wet weight to tibia length ratio controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. kidney mass male 112 days 9 0.73 g/cm 0.01 0.03 post excision weight measurement 0.0 0 67641 735
SS/HsdMcwiCrl urine sodium excretion rate controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. urine sodium amount male 112 days 7 6.0 mEq/d 0.9 2.38 automated urine analysis 0.0 0 67667 735
SS/HsdMcwiCrl sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) then phenylephrine (2 umol/l) then sodium nitroprusside (0.316 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasodilation trait male 112 days 7 [(maximum PE response − SNP response)/(maximum PE response − baseline before PE constriction)] × 100 97.36 % 0.65 1.72 wire myography mesenteric artery 0.0 0 BCA assay 67671 735
SS/HsdMcwiCrl urine total protein excretion rate controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. total urine protein amount male 112 days 9 1.0 mg/d 0.2 0.6 bicinchoninic acid protein assay 0.0 0 69613 735
SS/HsdMcwiCrl urine total protein excretion rate controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. total urine protein amount male 112 days 6 0.8 mg/d 0.06 0.15 bicinchoninic acid protein assay 0.0 0 69615 735
SS/HsdMcwiCrl acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) then phenylephrine (2 umol/l) then acetylcholine (3.16 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasodilation trait male 112 days 6 [(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] × 100 99.71 % 0.27 0.66 wire myography mesenteric artery 0.0 0 BCA assay 69616 735
SS/HsdMcwiCrl acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then phenylephrine (2 umol/l) then acetylcholine (3.16 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasodilation trait male 112 days 6 [(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] × 100 100.24 % 0.28 0.69 wire myography mesenteric artery 0.0 0 69618 735
SS/HsdMcwiCrl logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then phenylephrine (2 umol/l) then acetylcholine (0.001-9.5 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasodilation trait male 112 days 10 logEC50 -7.4 null 0.1 0.32 wire myography mesenteric artery 0.0 0 84641 735
SS/HsdMcwiCrl acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then phenylephrine (1 umol/l) then acetylcholine (31.6 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasodilation trait male 112 days 4 [(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] × 100 80.04 % 2.63 5.26 wire myography aorta 0.0 0 84654 735
SS/HsdMcwiCrl acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then phenylephrine (1 umol/l) then acetylcholine (31.6 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasodilation trait male 112 days 5 [(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] × 100 78.37 % 1.3 2.91 wire myography aorta 0.0 0 84655 735
SS/HsdMcwiCrl acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then phenylephrine (1 umol/l) then NG-nitroarginine methyl ester (100 umol/l) then acetylcholine (31.6 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasodilation trait male 112 days 7 [(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] × 100 -12.94 % 4.38 11.59 wire myography aorta 0.0 0 84658 735
SS/HsdMcwiCrl phenylephrine-induced blood vessel contractile force expressed as percent of force at baseline controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then phenylephrine (31.6 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasoconstriction trait male 112 days 10 [(response to vasoconstrictor - baseline before constriction)/baseline before constriction] x 100 607.58 % 51.55 163.02 wire myography mesenteric artery 0.0 0 phenylephrine-induced blood vessel constriction expressed as percent of force at baseline 84673 735
SS/HsdMcwiCrl phenylephrine-induced blood vessel contractile force expressed as percent of force at baseline controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then NG-nitroarginine methyl ester (100 umol/l) (for 0.2 hours) then phenylephrine (31.6 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasoconstriction trait male 112 days 9 [(response to vasoconstrictor - baseline before constriction)/baseline before constriction] x 100 626.89 % 61.39 184.17 wire myography mesenteric artery 0.0 0 phenylephrine-induced blood vessel constriction expressed as percent of force at baseline 84677 735
SS/HsdMcwiCrl potassium chloride-induced blood vessel contractile force expressed as percent of force at baseline controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) then potassium chloride solution (100 mmol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasoconstriction trait male 112 days 7 [(response to vasoconstrictor - baseline before constriction)/baseline before constriction] x 100 312.35 % 20.21 53.47 wire myography mesenteric artery 0.0 0 Kcl-induced blood vessel constriction expressed as percent of force at baseline 84680 735
SHR-Ndufc2em1Mcwi+/+ systolic blood pressure controlled protein content diet (19.7 %) (for 84 days) and controlled potassium content diet (6.3 mg/g) (for 84 days) and controlled sodium content diet (3.7 mg/g) (for 84 days) Rubattu S, et al., J Am Heart Assoc. 2016 Feb 17;5(2). pii: e002701. doi: 10.1161/JAHA.115.002701. arterial blood pressure trait not specified 126 days 10 undefined 188.0 mmHg 0.63 2.0 tail cuff plethysmography 0.0 0 97918 1938
SHR-Ndufc2em2Mcwi-/+ systolic blood pressure controlled protein content diet (19.7 %) (for 84 days) and controlled potassium content diet (6.3 mg/g) (for 84 days) and controlled sodium content diet (3.7 mg/g) (for 84 days) Rubattu S, et al., J Am Heart Assoc. 2016 Feb 17;5(2). pii: e002701. doi: 10.1161/JAHA.115.002701. arterial blood pressure trait not specified 126 days 16 undefined 186.0 mmHg 1.5 6.0 tail cuff plethysmography 0.0 0 97927 1938
SHR/Bbb urine total protein excretion rate controlled protein content diet (19.7 %) (for 56 days) and controlled potassium content diet (6.3 mg/g) (for 56 days) and controlled sodium content diet (3.7 mg/g) (for 56 days) Rubattu S, et al., J Am Heart Assoc. 2016 Feb 17;5(2). pii: e002701. doi: 10.1161/JAHA.115.002701. total urine protein amount not specified 98 days 18 68.0 mg/d 3.3 14.0 urine analysis 0.0 0 97929 1938
SHR-Ndufc2em1Mcwi+/+ urine total protein excretion rate controlled protein content diet (19.7 %) (for 84 days) and controlled potassium content diet (6.3 mg/g) (for 84 days) and controlled sodium content diet (3.7 mg/g) (for 84 days) Rubattu S, et al., J Am Heart Assoc. 2016 Feb 17;5(2). pii: e002701. doi: 10.1161/JAHA.115.002701. total urine protein amount not specified 126 days 10 67.0 mg/d 1.9 6.0 urine analysis 0.0 0 97935 1938
PXO5-2/Cub blood chylomicron cholesterol level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood chylomicron cholesterol amount male 127 days 10 0.42 mg/dl 0.05 0.16 enzymatic cholesterol assay 0.0 0 97360 1858
PXO1/Cub blood high density lipoprotein cholesterol level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood HDL cholesterol amount male 127 days 11 27.54 mg/dl 1.8 5.97 enzymatic cholesterol assay 0.0 0 97299 1858
SHR-Ndufc2em1Mcwi+/+ body weight controlled protein content diet (19.7 %) (for 28 days) and controlled potassium content diet (6.3 mg/g) (for 28 days) and controlled sodium content diet (3.7 mg/g) (for 28 days) Rubattu S, et al., J Am Heart Assoc. 2016 Feb 17;5(2). pii: e002701. doi: 10.1161/JAHA.115.002701. body mass not specified 70 days 10 235.0 g 4.74 15.0 body weighing method 0.0 0 97877 1938
PXO10/Cub liver weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. liver mass male 127 days 12 27.2 g/kg 0.3 1.04 post excision weight measurement 0.0 0 97207 1858
PXO10/Cub both adrenal glands weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. adrenal gland mass male 127 days 13 16.0 mg/100g 0.5 1.8 post excision weight measurement 0.0 0 97400 1858
PXO3-2/Cub both adrenal glands weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. adrenal gland mass male 127 days 9 17.0 mg/100g 0.3 0.9 post excision weight measurement 0.0 0 97401 1858
BXH2/Cub both adrenal glands weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. adrenal gland mass male 127 days 18 17.0 mg/100g 0.8 3.39 post excision weight measurement 0.0 0 97403 1858
PXO6-1/Cub blood very low density lipoprotein cholesterol level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood VLDL cholesterol amount male 127 days 10 0.81 mg/dl 0.12 0.38 enzymatic cholesterol assay 0.0 0 change to mg/dl when available 97240 1858
PXO8-2/Cub blood glycerol level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood glycerol amount male 127 days 13 4.34 mg/dl 0.28 1.01 enzymatic triglyceride assay 0.0 0 97569 1858
PXO9/Cub blood glycerol level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood glycerol amount male 127 days 9 4.35 mg/dl 0.19 0.57 enzymatic triglyceride assay 0.0 0 97570 1858
PXO5-1/Cub blood glycerol level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood glycerol amount male 127 days 11 5.45 mg/dl 0.39 1.29 enzymatic triglyceride assay 0.0 0 97575 1858
PXO5-2/Cub blood glycerol level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood glycerol amount male 127 days 10 5.84 mg/dl 0.28 0.89 enzymatic triglyceride assay 0.0 0 97576 1858
SHR.BN-(D8Mit5-D8Mgh6)/Ipcv blood very low density lipoprotein particle diameter controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood VLDL particle size male 127 days 13 40.5 nm 0.2 0.72 high-performance liquid chromatography 0.0 0 97667 1858
PXO5-2/Cub blood very low density lipoprotein cholesterol level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood VLDL cholesterol amount male 127 days 10 10.68 mg/dl 0.89 2.81 enzymatic cholesterol assay 0.0 0 change to mg/dl when available 97275 1858
PXO6-2/Cub both testes wet weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. testis mass male 127 days 8 0.91 % 0.08 0.23 post excision weight measurement 0.0 0 97499 1858
PXO6-2/Cub blood very low density lipoprotein triglyceride level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood VLDL triglyceride amount male 127 days 8 15.3 mg/dl 2.8 7.92 enzymatic triglyceride assay 0.0 0 97604 1858
SHR.BN-(D8Mit5-D8Mgh6)/Ipcv blood very low density lipoprotein triglyceride level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood VLDL triglyceride amount male 127 days 13 21.5 mg/dl 2.6 9.37 enzymatic triglyceride assay 0.0 0 97609 1858
PXO4/Cub blood total cholesterol level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood cholesterol amount male 127 days 9 66.5 mg/dl 1.3 3.9 enzymatic cholesterol assay 0.0 0 97225 1858
SHR.BN-(D8Mit5-D8Mgh6)/Ipcv blood total cholesterol level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood cholesterol amount male 127 days 13 53.7 mg/dl 1.2 4.33 enzymatic cholesterol assay 0.0 0 97216 1858
PXO9/Cub blood total cholesterol level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood cholesterol amount male 127 days 9 60.9 mg/dl 2.0 6.0 enzymatic cholesterol assay 0.0 0 97221 1858
PXO5-2/Cub blood low density lipoprotein cholesterol level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood LDL cholesterol amount male 127 days 10 17.35 mg/dl 0.72 2.28 enzymatic cholesterol assay 0.0 0 change to mg/dl when available 97290 1858
PXO10/Cub blood low density lipoprotein cholesterol level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood LDL cholesterol amount male 127 days 12 19.44 mg/dl 0.68 2.36 enzymatic cholesterol assay 0.0 0 change to mg/dl when available 97291 1858
PXO8-1/Cub blood very low density lipoprotein particle diameter controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood VLDL particle size male 127 days 10 40.1 nm 0.2 0.63 high-performance liquid chromatography 0.0 0 97665 1858
PXO8-1/Cub body weight controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. body mass male 127 days 10 279.1 g 4.2 13.28 body weighing method 0.0 0 97166 1858
PXO6-1/Cub blood chylomicron triglyceride level controlled sucrose content diet (70 % of calories) (for 7 days) and controlled protein content diet (19.6 % of calories) (for 7 days) and controlled fat content diet (10.4 % of calories) (for 7 days) then fasting (for 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood chylomicron triglyceride amount male 127 days 10 0.09 mg/dl 0.03 0.09 enzymatic triglyceride assay 0.0 0 97580 1858
PXO3-2/Cub blood chylomicron triglyceride level controlled sucrose content diet (70 % of calories) (for 7 days) and controlled protein content diet (19.6 % of calories) (for 7 days) and controlled fat content diet (10.4 % of calories) (for 7 days) then fasting (for 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood chylomicron triglyceride amount male 127 days 9 0.36 mg/dl 0.09 0.27 enzymatic triglyceride assay 0.0 0 97584 1858
PXO7-1/Cub blood chylomicron triglyceride level controlled sucrose content diet (70 % of calories) (for 7 days) and controlled protein content diet (19.6 % of calories) (for 7 days) and controlled fat content diet (10.4 % of calories) (for 7 days) then fasting (for 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood chylomicron triglyceride amount male 127 days 8 0.42 mg/dl 0.12 0.34 enzymatic triglyceride assay 0.0 0 97586 1858
PXO5-1/Cub blood chylomicron triglyceride level controlled sucrose content diet (70 % of calories) (for 7 days) and controlled protein content diet (19.6 % of calories) (for 7 days) and controlled fat content diet (10.4 % of calories) (for 7 days) then fasting (for 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood chylomicron triglyceride amount male 127 days 11 2.27 mg/dl 0.4 1.33 enzymatic triglyceride assay 0.0 0 97595 1858
BXH2/Cub blood low density lipoprotein triglyceride level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood LDL triglyceride amount male 127 days 18 10.7 mg/dl 1.1 4.67 enzymatic triglyceride assay 0.0 0 97621 1858
SHR/Bbb body weight controlled protein content diet (19.7 %) (for 28 days) and controlled potassium content diet (6.3 mg/g) (for 28 days) and controlled sodium content diet (3.7 mg/g) (for 28 days) Rubattu S, et al., J Am Heart Assoc. 2016 Feb 17;5(2). pii: e002701. doi: 10.1161/JAHA.115.002701. body mass not specified 70 days 18 220.0 g 3.06 13.0 body weighing method 0.0 0 97906 1938
SHR/Bbb body weight controlled protein content diet (19.7 %) (for 56 days) and controlled potassium content diet (6.3 mg/g) (for 56 days) and controlled sodium content diet (3.7 mg/g) (for 56 days) Rubattu S, et al., J Am Heart Assoc. 2016 Feb 17;5(2). pii: e002701. doi: 10.1161/JAHA.115.002701. body mass not specified 98 days 18 260.0 g 3.77 16.0 body weighing method 0.0 0 97907 1938
PXO6-1/Cub blood glycerol level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood glycerol amount male 127 days 10 3.34 mg/dl 0.15 0.47 enzymatic triglyceride assay 0.0 0 97560 1858
PXO2/Cub blood glycerol level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood glycerol amount male 127 days 11 4.03 mg/dl 0.19 0.63 enzymatic triglyceride assay 0.0 0 97565 1858
PXO3-2/Cub blood high density lipoprotein particle diameter controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood HDL particle size male 127 days 9 12.58 nm 0.03 0.09 high-performance liquid chromatography 0.0 0 97700 1858
PXO1/Cub retroperitoneal fat pad weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. retroperitoneal fat pad mass male 127 days 11 0.78 % 0.05 0.17 post excision weight measurement 0.0 0 97784 1858
PXO8-1/Cub retroperitoneal fat pad weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. retroperitoneal fat pad mass male 127 days 12 0.86 % 0.04 0.14 post excision weight measurement 0.0 0 97788 1858
PXO5-1/Cub retroperitoneal fat pad weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. retroperitoneal fat pad mass male 127 days 11 0.87 % 0.03 0.1 post excision weight measurement 0.0 0 97789 1858
SHR.BN-(D8Mit5-D8Mgh6)/Ipcv retroperitoneal fat pad weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. retroperitoneal fat pad mass male 127 days 13 0.96 % 0.06 0.22 post excision weight measurement 0.0 0 97790 1858
PXO3-1/Cub retroperitoneal fat pad weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. retroperitoneal fat pad mass male 127 days 10 1.28 % 0.07 0.22 post excision weight measurement 0.0 0 97792 1858
PXO10/Cub blood low density lipoprotein particle diameter controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood LDL particle size male 127 days 12 21.49 nm 0.09 0.31 high-performance liquid chromatography 0.0 0 97690 1858
PXO8-1/Cub blood high density lipoprotein particle diameter controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood HDL particle size male 127 days 10 12.55 nm 0.03 0.09 high-performance liquid chromatography 0.0 0 97698 1858
PXO3-1/Cub heart weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. heart mass male 127 days 10 3.7 g/kg 0.1 0.32 post excision weight measurement 0.0 0 97188 1858
PXO8-2/Cub heart weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. heart mass male 127 days 13 3.7 g/kg 0.1 0.36 post excision weight measurement 0.0 0 97189 1858
PXO6-1/Cub blood low density lipoprotein particle diameter controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood LDL particle size male 127 days 10 21.47 nm 0.15 0.47 high-performance liquid chromatography 0.0 0 97689 1858
SHR.BN-(D8Mit5-D8Mgh6)/Ipcv both kidneys wet weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. kidney mass male 127 days 13 6.2 g/kg 0.1 0.36 post excision weight measurement 0.0 0 97121 1858
PXO2/Cub both kidneys wet weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. kidney mass male 127 days 11 5.7 g/kg 0.1 0.33 post excision weight measurement 0.0 0 97125 1858
PXO8-2/Cub both kidneys wet weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. kidney mass male 127 days 13 5.5 g/kg 0.1 0.36 post excision weight measurement 0.0 0 97122 1858
PXO5-2/Cub both kidneys wet weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. kidney mass male 127 days 10 6.0 g/kg 0.1 0.32 post excision weight measurement 0.0 0 97156 1858
PXO6-3/Cub blood low density lipoprotein cholesterol level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood LDL cholesterol amount male 127 days 10 11.02 mg/dl 0.62 1.96 enzymatic cholesterol assay 0.0 0 change to mg/dl when available 97284 1858
PXO1/Cub blood triglyceride level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood triglyceride amount male 127 days 11 42.6 mg/dl 3.5 11.61 enzymatic triglyceride assay 0.0 0 97324 1858
PXO8-2/Cub blood triglyceride level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood triglyceride amount male 127 days 13 59.4 mg/dl 4.8 17.31 enzymatic triglyceride assay 0.0 0 97328 1858
PXO10/Cub blood low density lipoprotein triglyceride level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood LDL triglyceride amount male 127 days 12 7.1 mg/dl 0.4 1.39 enzymatic triglyceride assay 0.0 0 97617 1858
PXO4/Cub blood low density lipoprotein triglyceride level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood LDL triglyceride amount male 127 days 9 21.6 mg/dl 1.1 3.3 enzymatic triglyceride assay 0.0 0 97633 1858
BXH2/Cub blood high density lipoprotein triglyceride level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood HDL triglyceride amount male 127 days 18 3.07 mg/dl 0.17 0.72 enzymatic triglyceride assay 0.0 0 97638 1858
PXO5-2/Cub blood high density lipoprotein triglyceride level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood HDL triglyceride amount male 127 days 10 5.21 mg/dl 0.16 0.51 enzymatic triglyceride assay 0.0 0 97649 1858
BXH2/Cub blood very low density lipoprotein cholesterol level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood VLDL cholesterol amount male 127 days 18 4.82 mg/dl 0.67 2.84 enzymatic cholesterol assay 0.0 0 change to mg/dl when available 97268 1858
SHR.BN-(D8Mit5-D8Mgh6)/Ipcv both adrenal glands weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. adrenal gland mass male 127 days 13 10.0 mg/100g 0.3 1.08 post excision weight measurement 0.0 0 97340 1858
PXO3-2/Cub blood chylomicron cholesterol level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood chylomicron cholesterol amount male 127 days 9 0.02 mg/dl 0.0 0.01 enzymatic cholesterol assay 0.0 0 97347 1858
SHRSP/A3NCrl brain infarction volume controlled protein content diet (16 %) (between 28 and 120 days) and controlled sodium content diet (4 %) (for 28 days) and controlled potassium content diet (0.75 %) (for 28 days) and unilateral carotid artery occlusion (for 28 days) Yang Y, etal., Neurobiol Dis. 2018 Jun;114:95-110. doi: 10.1016/j.nbd.2018.02.012. Epub 2018 Feb 24. brain integrity trait male 112 days 8 28.4 mm3 4.6 13.01 magnetic resonance imaging corpus callosum 0.0 0 corpus callosum- left hemisphere corpus callosum- left hemisphere 107281 3079
Crl:SD urine total protein excretion rate controlled protein content diet (20 %) Zoja C, etal., Am J Med. 1992 Apr 27;92(4B):60S-63S. doi: 10.1016/0002-9343(92)90149-6. total urine protein amount male 420 days-540 days 9 54.0 mg/d 5.0 15.0 Bradford protein assay 0.0 0 108595 3126
Crl:SD urine total protein excretion rate controlled protein content diet (20 %) then water (for 120 days) Zoja C, etal., Am J Med. 1992 Apr 27;92(4B):60S-63S. doi: 10.1016/0002-9343(92)90149-6. total urine protein amount male 540 days-660 days 9 57.0 mg/d 5.0 15.0 Bradford protein assay 0.0 0 108596 3126
SS/HsdMcwiCrl food intake rate controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. eating behavior trait male 112 days 5 25.4 g/d 1.2 2.68 unspecified method 0.0 0 67662 735
SS/HsdMcwiCrl water drink intake rate controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. drinking behavior trait male 112 days 7 18.4 ml/d 2.4 6.35 unspecified method 0.0 0 67665 735
BN/CrlCrlj blood glucose level controlled protein content diet (for 120 days) then fasting (for 9 hours) Tsuji A, et al., Genomics 2001 Jun 15;74(3):365-9. blood glucose amount male 120 days 5 145.1 mg/dl 16.4 36.67 oral glucose tolerance test glucose challenge 0 min serum glucose WBN/Kob rats were studied as a model of pancreatitis and diabetes mellitus 12907 321
BN/CrlCrlj blood glucose level controlled protein content diet (for 120 days) then fasting (for 9 hours) then glucose solution Tsuji A, et al., Genomics 2001 Jun 15;74(3):365-9. blood glucose amount male 120 days 5 154.7 mg/dl 13.8 30.86 oral glucose tolerance test glucose challenge 120 min glucose dose not specified serum glucose WBN/Kob rats were studied as a model of pancreatitis and diabetes mellitus 12910 321
SS/HsdMcwiCrl logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then phenylephrine (2 umol/l) then NG-nitroarginine methyl ester (100 umol/l) then acetylcholine (0.001-9.5 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasodilation trait male 112 days 8 logEC50 -6.3 null 0.2 0.57 wire myography mesenteric artery 0.0 0 84645 735
SS/HsdMcwiCrl logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then phenylephrine (2 umol/l) then sodium nitroprusside (0.316 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasodilation trait male 112 days 5 logEC50 -8.4 null 0.21 0.47 wire myography mesenteric artery 0.0 0 BCA assay 84651 735
SS/HsdMcwiCrl acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then phenylephrine (1 umol/l) then acetylcholine (31.6 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasodilation trait male 112 days 7 [(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] × 100 73.42 % 5.62 14.87 wire myography aorta 0.0 0 84653 735
SS/HsdMcwiCrl urine total protein excretion rate controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. total urine protein amount male 112 days 6 0.7 mg/d 0.07 0.17 bicinchoninic acid protein assay 0.0 0 69614 735
SS/HsdMcwiCrl acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then phenylephrine (2 umol/l) then NG-nitroarginine methyl ester (100 umol/l) then acetylcholine (3.16 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasodilation trait male 112 days 6 [(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] × 100 92.95 % 1.46 3.58 wire myography mesenteric artery 0.0 0 69623 735
SS/HsdMcwiCrl logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then phenylephrine (1 umol/l) then acetylcholine (0-95 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasodilation trait male 112 days 7 logEC50 -6.33 null 0.25 0.66 wire myography aorta 0.0 0 84665 735
SS/HsdMcwiCrl phenylephrine-induced blood vessel contractile force expressed as percent of force at baseline controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then phenylephrine (31.6 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasoconstriction trait male 112 days 6 [(response to vasoconstrictor - baseline before constriction)/baseline before constriction] x 100 542.39 % 49.85 122.11 wire myography mesenteric artery 0.0 0 phenylephrine-induced blood vessel constriction expressed as percent of force at baseline 84674 735
PXO5-2/Cub body weight controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. body mass male 127 days 10 220.6 g 3.3 10.44 body weighing method 0.0 0 97157 1858
PXO5-2/Cub blood chylomicron triglyceride level controlled sucrose content diet (70 % of calories) (for 7 days) and controlled protein content diet (19.6 % of calories) (for 7 days) and controlled fat content diet (10.4 % of calories) (for 7 days) then fasting (for 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood chylomicron triglyceride amount male 127 days 10 3.85 mg/dl 0.31 0.98 enzymatic triglyceride assay 0.0 0 97596 1858
PXO5-1/Cub blood high density lipoprotein particle diameter controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood HDL particle size male 127 days 11 12.35 nm 0.07 0.23 high-performance liquid chromatography 0.0 0 97693 1858
SHR.BN-(D8Mit5-D8Mgh6)/Ipcv body weight controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. body mass male 127 days 13 328.0 g 4.0 14.42 body weighing method 0.0 0 97101 1858
PXO5-2/Cub heart weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. heart mass male 127 days 10 3.8 g/kg 0.2 0.63 post excision weight measurement 0.0 0 97190 1858
PXO10/Cub blood triglyceride level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood triglyceride amount male 127 days 12 23.5 mg/dl 2.6 9.01 enzymatic triglyceride assay 0.0 0 97314 1858
PXO5-2/Cub liver weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. liver mass male 127 days 10 26.5 g/kg 0.2 0.63 post excision weight measurement 0.0 0 97206 1858
BXH2/Cub blood total cholesterol level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood cholesterol amount male 127 days 18 48.7 mg/dl 1.6 6.79 enzymatic cholesterol assay 0.0 0 97211 1858
PXO3-2/Cub blood total cholesterol level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood cholesterol amount male 127 days 9 58.5 mg/dl 2.7 8.1 enzymatic cholesterol assay 0.0 0 97219 1858
PXO4/Cub blood low density lipoprotein cholesterol level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood LDL cholesterol amount male 127 days 9 19.47 mg/dl 1.06 3.18 enzymatic cholesterol assay 0.0 0 change to mg/dl when available 97292 1858
PXO6-3/Cub both testes wet weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. testis mass male 127 days 10 1.08 % 0.02 0.06 post excision weight measurement 0.0 0 97507 1858
PXO5-2/Cub both testes wet weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. testis mass male 127 days 10 1.24 % 0.01 0.03 post excision weight measurement 0.0 0 97512 1858
PXO9/Cub blood very low density lipoprotein cholesterol level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood VLDL cholesterol amount male 127 days 9 7.02 mg/dl 1.08 3.24 enzymatic cholesterol assay 0.0 0 change to mg/dl when available 97272 1858
PXO1/Cub body weight controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. body mass male 127 days 11 257.2 g 5.2 17.25 body weighing method 0.0 0 97163 1858
PXO4/Cub blood high density lipoprotein cholesterol level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood HDL cholesterol amount male 127 days 9 43.61 mg/dl 0.92 2.76 enzymatic cholesterol assay 0.0 0 97307 1858
PXO3-2/Cub blood high density lipoprotein cholesterol level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood HDL cholesterol amount male 127 days 9 46.2 mg/dl 2.14 6.42 enzymatic cholesterol assay 0.0 0 97312 1858
SS/HsdMcwiCrl heart weight to tibia length ratio controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. heart mass male 112 days 8 0.32 g/cm 0.01 0.03 post excision weight measurement 0.0 0 67621 735
SS/HsdMcwiCrl epididymal fat pad weight to tibia length ratio controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. epididymal fat pad mass male 112 days 7 1.17 g/cm 0.05 0.13 post excision weight measurement 0.0 0 67652 735
SS/HsdMcwiCrl urine sodium excretion rate controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. urine sodium amount male 112 days 4 5.9 mEq/d 0.4 0.8 automated urine analysis 0.0 0 67670 735
SS/HsdMcwiCrl tibia length controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. tibia length male 112 days 9 4.26 cm 0.02 0.06 unspecified method 0.0 0 67611 735
SS/HsdMcwiCrl acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then phenylephrine (2 umol/l) then NG-nitroarginine methyl ester (100 umol/l) then acetylcholine (3.16 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasodilation trait male 112 days 10 [(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] × 100 64.5 % 15.34 48.51 wire myography mesenteric artery 0.0 0 69621 735
SS/HsdMcwiCrl acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then phenylephrine (2 umol/l) then NG-nitroarginine methyl ester (100 umol/l) then acetylcholine (3.16 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasodilation trait male 112 days 6 [(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] × 100 91.96 % 2.76 6.76 wire myography mesenteric artery 0.0 0 69622 735
BN/CrlCrlj percentage of study population developing chronic pancreatitis during a period of time controlled protein content diet Tsuji A, et al., Genomics 2001 Jun 15;74(3):365-9. pancreas integrity trait male 150 days 6 0.0 % ex vivo light microscopy 0.0 0 67777 321
COP liver remodeling tumorous lesion number to liver total tumorous lesion number ratio N-nitrosodiethylamine (150 mg/kg) then controlled protein content diet (for 15 days) and 2-acetamidofluorene (0.02 %) (for 15 days) then partial hepatectomy (for 202.5 days) De Miglio MR, et al., Int J Cancer 2004 Aug 10;111(1):9-16. liver integrity trait male 0 days 10 83.0 % ex vivo light microscopy with digital image analysis liver 0.0 224 days 70203 1302
SS/HsdMcwiCrl acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) then phenylephrine (1 umol/l) then acetylcholine (31.6 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasodilation trait male 112 days 4 [(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] × 100 70.84 % 4.18 8.36 wire myography aorta 0.0 0 BCA assay 84652 735
SS/HsdMcwiCrl acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then phenylephrine (1 umol/l) then NG-nitroarginine methyl ester (100 umol/l) then acetylcholine (31.6 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasodilation trait male 112 days 10 [(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] × 100 -29.33 % 4.38 13.85 wire myography aorta 0.0 0 84657 735
F344/NRrrc ratio of apoptotic bodies to intact tumor cells in remodelling liver tumorous lesions N-nitrosodiethylamine (150 mg/kg) then controlled protein content diet (for 15 days) and controlled 2-acetamidofluorene content diet (0.02 %) then partial hepatectomy De Miglio MR, et al., Int J Cancer 2003 May 20;105(1):70-5. liver integrity trait not specified 0 days 5 1.51 % 0.07 0.16 ex vivo light microscopy with immunohistochemistry and digital image analysis 0.0 0 84787 1603
SS/HsdMcwiCrl logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then phenylephrine (2 umol/l) then acetylcholine (0.001-9.5 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasodilation trait male 112 days 4 logEC50 -7.1 null 0.1 0.2 wire myography mesenteric artery 0.0 0 logEC50 84640 735
SS/HsdMcwiCrl logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then phenylephrine (1 umol/l) then acetylcholine (0-95 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasodilation trait male 112 days 4 logEC50 -6.49 null 0.13 0.26 wire myography aorta 0.0 0 84666 735
PXO8-2/Cub both testes wet weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. testis mass male 127 days 13 1.08 % 0.02 0.07 post excision weight measurement 0.0 0 97506 1858
PXO5-1/Cub both testes wet weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. testis mass male 127 days 11 1.15 % 0.02 0.07 post excision weight measurement 0.0 0 97511 1858
PXO1/Cub epididymal fat pad weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. epididymal fat pad mass male 127 days 11 0.9 % 0.02 0.07 post excision weight measurement 0.0 0 97520 1858
PXO8-2/Cub blood very low density lipoprotein particle diameter controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood VLDL particle size male 127 days 13 40.8 nm 0.2 0.72 high-performance liquid chromatography 0.0 0 97668 1858
PXO2/Cub blood very low density lipoprotein particle diameter controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood VLDL particle size male 127 days 11 42.9 nm 0.4 1.33 high-performance liquid chromatography 0.0 0 97674 1858
PXO6-1/Cub blood triglyceride level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood triglyceride amount male 127 days 10 27.0 mg/dl 1.0 3.16 enzymatic triglyceride assay 0.0 0 97315 1858
PXO1/Cub blood low density lipoprotein triglyceride level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood LDL triglyceride amount male 127 days 11 12.6 mg/dl 0.7 2.32 enzymatic triglyceride assay 0.0 0 97623 1858
PXO3-2/Cub blood low density lipoprotein triglyceride level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood LDL triglyceride amount male 127 days 9 14.8 mg/dl 0.6 1.8 enzymatic triglyceride assay 0.0 0 97624 1858
PXO8-1/Cub blood low density lipoprotein triglyceride level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood LDL triglyceride amount male 127 days 10 17.3 mg/dl 0.9 2.85 enzymatic triglyceride assay 0.0 0 97627 1858
PXO6-1/Cub blood low density lipoprotein triglyceride level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood LDL triglyceride amount male 127 days 10 18.5 mg/dl 0.5 1.58 enzymatic triglyceride assay 0.0 0 97630 1858
PXO9/Cub blood high density lipoprotein triglyceride level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood HDL triglyceride amount male 127 days 9 2.87 mg/dl 0.16 0.48 enzymatic triglyceride assay 0.0 0 97636 1858
PXO1/Cub blood high density lipoprotein triglyceride level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood HDL triglyceride amount male 127 days 11 3.78 mg/dl 0.14 0.46 enzymatic triglyceride assay 0.0 0 97644 1858
PXO8-1/Cub blood high density lipoprotein triglyceride level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood HDL triglyceride amount male 127 days 10 3.85 mg/dl 0.33 1.04 enzymatic triglyceride assay 0.0 0 97645 1858
PXO4/Cub blood high density lipoprotein triglyceride level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood HDL triglyceride amount male 127 days 9 4.09 mg/dl 0.18 0.54 enzymatic triglyceride assay 0.0 0 97646 1858
PXO5-1/Cub blood high density lipoprotein triglyceride level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood HDL triglyceride amount male 127 days 11 5.55 mg/dl 0.48 1.59 enzymatic triglyceride assay 0.0 0 97650 1858
PXO6-3/Cub blood very low density lipoprotein cholesterol level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood VLDL cholesterol amount male 127 days 10 1.36 mg/dl 0.14 0.44 enzymatic cholesterol assay 0.0 0 change to mg/dl when available 97260 1858
PXO3-1/Cub blood very low density lipoprotein cholesterol level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood VLDL cholesterol amount male 127 days 10 2.26 mg/dl 0.17 0.54 enzymatic cholesterol assay 0.0 0 change to mg/dl when available 97263 1858
SHR.BN-(D8Mit5-D8Mgh6)/Ipcv blood very low density lipoprotein cholesterol level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood VLDL cholesterol amount male 127 days 13 6.85 mg/dl 0.53 1.91 enzymatic cholesterol assay 0.0 0 change to mg/dl when available 97271 1858
PXO6-2/Cub blood chylomicron cholesterol level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood chylomicron cholesterol amount male 127 days 8 0.02 mg/dl 0.01 0.03 enzymatic cholesterol assay 0.0 0 97346 1858
PXO6-2/Cub blood high density lipoprotein particle diameter controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood HDL particle size male 127 days 8 12.39 nm 0.02 0.06 high-performance liquid chromatography 0.0 0 97695 1858
PXO5-2/Cub blood low density lipoprotein particle diameter controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood LDL particle size male 127 days 10 21.96 nm 0.19 0.6 high-performance liquid chromatography 0.0 0 97709 1858
PXO6-2/Cub heart weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. heart mass male 127 days 8 3.7 g/kg 0.2 0.57 post excision weight measurement 0.0 0 97185 1858
PXO3-1/Cub blood low density lipoprotein particle diameter controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood LDL particle size male 127 days 10 20.51 nm 0.12 0.38 high-performance liquid chromatography 0.0 0 97677 1858
PXO9/Cub blood low density lipoprotein particle diameter controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood LDL particle size male 127 days 9 21.46 nm 0.08 0.24 high-performance liquid chromatography 0.0 0 97688 1858
PXO6-3/Cub body weight controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. body mass male 127 days 10 235.6 g 6.8 21.5 body weighing method 0.0 0 97159 1858
PXO3-2/Cub blood low density lipoprotein particle diameter controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood LDL particle size male 127 days 9 20.36 nm 0.05 0.15 high-performance liquid chromatography 0.0 0 97676 1858
PXO8-1/Cub both kidneys wet weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. kidney mass male 127 days 10 5.6 g/kg 0.04 0.13 post excision weight measurement 0.0 0 97123 1858
PXO3-1/Cub blood low density lipoprotein cholesterol level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood LDL cholesterol amount male 127 days 10 10.28 mg/dl 0.28 0.89 enzymatic cholesterol assay 0.0 0 change to mg/dl when available 97280 1858
PXO4/Cub both kidneys wet weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. kidney mass male 127 days 9 6.3 g/kg 0.1 0.3 post excision weight measurement 0.0 0 97153 1858
PXO9/Cub liver weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. liver mass male 127 days 9 24.9 g/kg 0.5 1.5 post excision weight measurement 0.0 0 97198 1858
PXO8-1/Cub liver weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. liver mass male 127 days 10 24.9 g/kg 0.3 0.95 post excision weight measurement 0.0 0 97199 1858
SHR/Bbb urine total protein excretion rate controlled protein content diet (19.7 %) (for 84 days) and controlled potassium content diet (6.3 mg/g) (for 84 days) and controlled sodium content diet (3.7 mg/g) (for 84 days) Rubattu S, et al., J Am Heart Assoc. 2016 Feb 17;5(2). pii: e002701. doi: 10.1161/JAHA.115.002701. total urine protein amount not specified 126 days 18 85.0 mg/d 3.77 16.0 urine analysis 0.0 0 97930 1938
SHR-Ndufc2em1Mcwi-/+ urine total protein excretion rate controlled protein content diet (19.7 %) (for 56 days) and controlled potassium content diet (6.3 mg/g) (for 56 days) and controlled sodium content diet (3.7 mg/g) (for 56 days) Rubattu S, et al., J Am Heart Assoc. 2016 Feb 17;5(2). pii: e002701. doi: 10.1161/JAHA.115.002701. total urine protein amount not specified 98 days 17 43.0 mg/d 1.46 6.0 urine analysis 0.0 0 97937 1938
SHR-Ndufc2em1Mcwi-/+ urine total protein excretion rate controlled protein content diet (19.7 %) (for 84 days) and controlled potassium content diet (6.3 mg/g) (for 84 days) and controlled sodium content diet (3.7 mg/g) (for 84 days) Rubattu S, et al., J Am Heart Assoc. 2016 Feb 17;5(2). pii: e002701. doi: 10.1161/JAHA.115.002701. total urine protein amount not specified 126 days 17 71.0 mg/d 4.61 19.0 urine analysis 0.0 0 97938 1938
SHR-Ndufc2em2Mcwi+/+ urine total protein excretion rate controlled protein content diet (19.7 %) (for 84 days) and controlled potassium content diet (6.3 mg/g) (for 84 days) and controlled sodium content diet (3.7 mg/g) (for 84 days) Rubattu S, et al., J Am Heart Assoc. 2016 Feb 17;5(2). pii: e002701. doi: 10.1161/JAHA.115.002701. total urine protein amount not specified 126 days 12 72.0 mg/d 6.35 22.0 urine analysis 0.0 0 97941 1938
SHR-Ndufc2em2Mcwi-/+ urine total protein excretion rate controlled protein content diet (19.7 %) (for 28 days) and controlled potassium content diet (6.3 mg/g) (for 28 days) and controlled sodium content diet (3.7 mg/g) (for 28 days) Rubattu S, et al., J Am Heart Assoc. 2016 Feb 17;5(2). pii: e002701. doi: 10.1161/JAHA.115.002701. total urine protein amount not specified 70 days 26 84.0 mg/d 6.86 35.0 urine analysis 0.0 0 97942 1938
PXO8-2/Cub blood total cholesterol level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood cholesterol amount male 127 days 13 61.0 mg/dl 1.3 4.69 enzymatic cholesterol assay 0.0 0 97222 1858
PXO4/Cub blood very low density lipoprotein particle diameter controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood VLDL particle size male 127 days 9 39.5 nm 0.4 1.2 high-performance liquid chromatography 0.0 0 97662 1858
PXO3-1/Cub blood very low density lipoprotein particle diameter controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood VLDL particle size male 127 days 10 40.4 nm 0.2 0.63 high-performance liquid chromatography 0.0 0 97666 1858
PXO2/Cub epididymal fat pad weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. epididymal fat pad mass male 127 days 11 1.25 % 0.05 0.17 post excision weight measurement 0.0 0 97527 1858
PXO6-3/Cub blood very low density lipoprotein triglyceride level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood VLDL triglyceride amount male 127 days 10 13.1 mg/dl 1.3 4.11 enzymatic triglyceride assay 0.0 0 97602 1858
BXH2/Cub blood very low density lipoprotein triglyceride level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood VLDL triglyceride amount male 127 days 18 15.3 mg/dl 1.0 4.24 enzymatic triglyceride assay 0.0 0 97603 1858
PXO1/Cub blood very low density lipoprotein triglyceride level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood VLDL triglyceride amount male 127 days 11 25.0 mg/dl 2.8 9.29 enzymatic triglyceride assay 0.0 0 97610 1858
PXO6-2/Cub both testes wet weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. testis mass male 127 days 8 0.99 % 0.02 0.06 post excision weight measurement 0.0 0 97502 1858
PXO6-2/Cub blood total cholesterol level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood cholesterol amount male 127 days 8 61.7 mg/dl 2.6 7.35 enzymatic cholesterol assay 0.0 0 97223 1858
PXO10/Cub blood total cholesterol level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood cholesterol amount male 127 days 12 49.4 mg/dl 2.0 6.93 enzymatic cholesterol assay 0.0 0 97212 1858
PXO5-2/Cub blood total cholesterol level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood cholesterol amount male 127 days 10 60.6 mg/dl 1.4 4.43 enzymatic cholesterol assay 0.0 0 97220 1858
PXO7-1/Cub blood low density lipoprotein cholesterol level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood LDL cholesterol amount male 127 days 8 12.24 mg/dl 0.39 1.1 enzymatic cholesterol assay 0.0 0 change to mg/dl when available 97286 1858
PXO5-2/Cub blood triglyceride level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood triglyceride amount male 127 days 10 92.4 mg/dl 6.6 20.87 enzymatic triglyceride assay 0.0 0 97330 1858
PXO6-3/Cub blood very low density lipoprotein particle diameter controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood VLDL particle size male 127 days 10 39.7 nm 0.2 0.63 high-performance liquid chromatography 0.0 0 97664 1858
PXO7-1/Cub both adrenal glands weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. adrenal gland mass male 127 days 8 15.0 mg/100g 0.5 1.41 post excision weight measurement 0.0 0 97396 1858
PXO9/Cub blood chylomicron cholesterol level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood chylomicron cholesterol amount male 127 days 9 0.08 mg/dl 0.02 0.06 enzymatic cholesterol assay 0.0 0 97354 1858
SHR.BN-(D8Mit5-D8Mgh6)/Ipcv blood high density lipoprotein cholesterol level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood HDL cholesterol amount male 127 days 13 25.67 mg/dl 0.67 2.42 enzymatic cholesterol assay 0.0 0 97298 1858
PXO5-1/Cub blood high density lipoprotein cholesterol level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood HDL cholesterol amount male 127 days 11 36.37 mg/dl 1.47 4.88 enzymatic cholesterol assay 0.0 0 97304 1858
PXO2/Cub blood high density lipoprotein cholesterol level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood HDL cholesterol amount male 127 days 11 46.23 mg/dl 1.97 6.53 enzymatic cholesterol assay 0.0 0 97313 1858
PXO3-1/Cub blood triglyceride level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood triglyceride amount male 127 days 10 27.4 mg/dl 0.9 2.85 enzymatic triglyceride assay 0.0 0 97316 1858
PXO4/Cub both testes wet weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. testis mass male 127 days 9 1.01 % 0.01 0.03 post excision weight measurement 0.0 0 97503 1858
PXO8-1/Cub blood glycerol level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood glycerol amount male 127 days 10 4.47 mg/dl 0.2 0.63 enzymatic triglyceride assay 0.0 0 97571 1858
SHR/Bbb systolic blood pressure controlled protein content diet (19.7 %) (for 56 days) and controlled potassium content diet (6.3 mg/g) (for 56 days) and controlled sodium content diet (3.7 mg/g) (for 56 days) Rubattu S, et al., J Am Heart Assoc. 2016 Feb 17;5(2). pii: e002701. doi: 10.1161/JAHA.115.002701. arterial blood pressure trait not specified 98 days 18 undefined 189.0 mmHg 1.41 6.0 tail cuff plethysmography 0.0 0 97912 1938
PXO5-1/Cub body weight controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. body mass male 127 days 11 235.1 g 4.8 15.92 body weighing method 0.0 0 97158 1858
PXO3-2/Cub body weight controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. body mass male 127 days 9 307.6 g 5.8 17.4 body weighing method 0.0 0 97171 1858
SHR-Ndufc2em1Mcwi-/+ body weight controlled protein content diet (19.7 %) (for 84 days) and controlled potassium content diet (6.3 mg/g) (for 84 days) and controlled sodium content diet (3.7 mg/g) (for 84 days) Rubattu S, et al., J Am Heart Assoc. 2016 Feb 17;5(2). pii: e002701. doi: 10.1161/JAHA.115.002701. body mass not specified 126 days 17 308.0 g 5.09 21.0 body weighing method 0.0 0 97897 1938
SHR/Bbb body weight controlled protein content diet (19.7 %) (for 84 days) and controlled potassium content diet (6.3 mg/g) (for 84 days) and controlled sodium content diet (3.7 mg/g) (for 84 days) Rubattu S, et al., J Am Heart Assoc. 2016 Feb 17;5(2). pii: e002701. doi: 10.1161/JAHA.115.002701. body mass not specified 126 days 18 289.0 g 1.89 8.0 body weighing method 0.0 0 97908 1938
PXO4/Cub retroperitoneal fat pad weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. retroperitoneal fat pad mass male 127 days 9 0.46 % 0.03 0.09 post excision weight measurement 0.0 0 97779 1858
PXO7-1/Cub retroperitoneal fat pad weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. retroperitoneal fat pad mass male 127 days 8 0.84 % 0.06 0.17 post excision weight measurement 0.0 0 97785 1858
PXO10/Cub retroperitoneal fat pad weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. retroperitoneal fat pad mass male 127 days 12 0.86 % 0.06 0.21 post excision weight measurement 0.0 0 97786 1858
Crl:SD systolic blood pressure controlled protein content diet (20 %) then water (for 120 days) Zoja C, etal., Am J Med. 1992 Apr 27;92(4B):60S-63S. doi: 10.1016/0002-9343(92)90149-6. arterial blood pressure trait male 540 days-660 days 9 168.0 mmHg 6.0 18.0 tail cuff plethysmography tail 0.0 0 108593 3126
SS/HsdMcwiCrl food intake rate controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. eating behavior trait male 112 days 9 21.4 g/d 1.1 3.3 unspecified method 0.0 0 67660 735
SS/HsdMcwiCrl both kidneys wet weight to tibia length ratio controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. kidney mass male 112 days 8 0.75 g/cm 0.03 0.08 post excision weight measurement 0.0 0 67643 735
F344/NRrrc liver remodeling tumorous lesion number to liver total tumorous lesion number ratio N-nitrosodiethylamine (150 mg/kg) then controlled protein content diet (for 15 days) and 2-acetamidofluorene (0.02 %) (for 15 days) then partial hepatectomy (for 202.5 days) De Miglio MR, et al., Int J Cancer 2004 Aug 10;111(1):9-16. liver integrity trait male 0 days 10 19.0 % ex vivo light microscopy with digital image analysis liver 0.0 224 days 70204 1302
SS/HsdMcwiCrl acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then phenylephrine (2 umol/l) then acetylcholine (3.16 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasodilation trait male 112 days 10 [(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] × 100 99.53 % 0.41 1.3 wire myography mesenteric artery 0.0 0 69617 735
SS/HsdMcwiCrl tibia length controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. tibia length male 112 days 6 4.3 cm 0.03 0.07 unspecified method 0.0 0 67612 735
SS/HsdMcwiCrl sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) then phenylephrine (1 umol/l) then sodium nitroprusside (3.16 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasodilation trait male 112 days 6 [(maximum PE response − SNP response)/(maximum PE response − baseline before PE constriction)] × 100 98.76 % 0.68 1.67 wire myography aorta 0.0 0 BCA assay 84660 735
SS/HsdMcwiCrl acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then phenylephrine (1 umol/l) then sodium nitroprusside (3.16 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasodilation trait male 112 days 0 [(maximum PE response − SNP response)/(maximum PE response − baseline before PE constriction)] × 100 95.47 % 2.53 wire myography aorta 0.0 0 BCA assay 84662 735
SS/HsdMcwiCrl phenylephrine-induced blood vessel contractile force expressed as percent of force at baseline controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then NG-nitroarginine methyl ester (100 umol/l) (for 0.2 hours) then phenylephrine (31.6 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasoconstriction trait male 112 days 5 [(response to vasoconstrictor - baseline before constriction)/baseline before constriction] x 100 665.33 % 79.91 178.68 wire myography mesenteric artery 0.0 0 phenylephrine-induced blood vessel constriction expressed as percent of force at baseline 84679 735
PXO7-1/Cub blood chylomicron cholesterol level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood chylomicron cholesterol amount male 127 days 8 0.02 mg/dl 0.01 0.03 enzymatic cholesterol assay 0.0 0 97348 1858
PXO8-2/Cub blood chylomicron cholesterol level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood chylomicron cholesterol amount male 127 days 13 0.05 mg/dl 0.01 0.04 enzymatic cholesterol assay 0.0 0 97351 1858
BXH2/Cub blood high density lipoprotein cholesterol level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood HDL cholesterol amount male 127 days 18 28.01 mg/dl 2.08 8.82 enzymatic cholesterol assay 0.0 0 97300 1858
BXH2/Cub blood triglyceride level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood triglyceride amount male 127 days 18 30.1 mg/dl 1.7 7.21 enzymatic triglyceride assay 0.0 0 97317 1858
PXO3-1/Cub liver weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. liver mass male 127 days 10 27.5 g/kg 0.3 0.95 post excision weight measurement 0.0 0 97209 1858
PXO6-3/Cub both adrenal glands weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. adrenal gland mass male 127 days 10 15.0 mg/100g 1.1 3.48 post excision weight measurement 0.0 0 97399 1858
PXO6-2/Cub both adrenal glands weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. adrenal gland mass male 127 days 8 17.0 mg/100g 0.7 1.98 post excision weight measurement 0.0 0 97405 1858
PXO3-1/Cub both testes wet weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. testis mass male 127 days 10 1.01 % 0.04 0.13 post excision weight measurement 0.0 0 97504 1858
BXH2/Cub blood very low density lipoprotein particle diameter controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood VLDL particle size male 127 days 18 42.6 nm 0.5 2.12 high-performance liquid chromatography 0.0 0 97673 1858
PXO8-1/Cub blood very low density lipoprotein cholesterol level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood VLDL cholesterol amount male 127 days 10 3.44 mg/dl 0.25 0.79 enzymatic cholesterol assay 0.0 0 change to mg/dl when available 97266 1858
PXO2/Cub blood very low density lipoprotein cholesterol level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood VLDL cholesterol amount male 127 days 11 5.0 mg/dl 0.51 1.69 enzymatic cholesterol assay 0.0 0 change to mg/dl when available 97269 1858
PXO4/Cub blood low density lipoprotein particle diameter controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood LDL particle size male 127 days 9 21.1 nm 0.1 0.3 high-performance liquid chromatography 0.0 0 97683 1858
PXO2/Cub blood high density lipoprotein particle diameter controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood HDL particle size male 127 days 11 12.76 nm 0.03 0.1 high-performance liquid chromatography 0.0 0 97705 1858
BXH2/Cub blood chylomicron triglyceride level controlled sucrose content diet (70 % of calories) (for 7 days) and controlled protein content diet (19.6 % of calories) (for 7 days) and controlled fat content diet (10.4 % of calories) (for 7 days) then fasting (for 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood chylomicron triglyceride amount male 127 days 18 1.03 mg/dl 0.23 0.98 enzymatic triglyceride assay 0.0 0 97593 1858
PXO5-1/Cub blood low density lipoprotein particle diameter controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood LDL particle size male 127 days 11 21.21 nm 0.18 0.6 high-performance liquid chromatography 0.0 0 97686 1858
PXO6-2/Cub blood low density lipoprotein particle diameter controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood LDL particle size male 127 days 8 20.9 nm 0.07 0.2 high-performance liquid chromatography 0.0 0 97681 1858
PXO3-2/Cub both testes wet weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. testis mass male 127 days 9 0.99 % 0.02 0.06 post excision weight measurement 0.0 0 97501 1858
PXO5-1/Cub epididymal fat pad weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. epididymal fat pad mass male 127 days 11 1.32 % 0.03 0.1 post excision weight measurement 0.0 0 97530 1858
PXO5-1/Cub blood total cholesterol level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood cholesterol amount male 127 days 11 53.3 mg/dl 2.4 7.96 enzymatic cholesterol assay 0.0 0 97214 1858
BN/CrlCrlj serum insulin level controlled protein content diet (for 120 days) then fasting (for 9 hours) Tsuji A, et al., Genomics 2001 Jun 15;74(3):365-9. blood insulin amount male 120 days 5 0.0 mg/dl 0.0 0.0 oral glucose tolerance test glucose challenge 0 min serum glucose 12911 321
WBN/KobSlc blood glucose level controlled protein content diet (for 120 days) then fasting (for 9 hours) then glucose solution Tsuji A, et al., Genomics 2001 Jun 15;74(3):365-9. blood glucose amount male 120 days 5 266.7 mg/dl 13.9 31.08 oral glucose tolerance test glucose challenge 30 min glucose dose not specified serum glucose WBN/Kob rats were studied as a model of pancreatitis and diabetes mellitus 12892 321
WBN/KobSlc blood glucose level controlled protein content diet (for 120 days) then fasting (for 9 hours) then glucose solution Tsuji A, et al., Genomics 2001 Jun 15;74(3):365-9. blood glucose amount male 120 days 5 313.5 mg/dl 25.9 57.91 oral glucose tolerance test glucose challenge 60 min glucose dose not specified serum glucose WBN/Kob rats were studied as a model of pancreatitis and diabetes mellitus 12895 321
WBN/KobSlc body weight controlled protein content diet Tsuji A, et al., Genomics 2001 Jun 15;74(3):365-9. body mass male 120 days 5 332.7 g 6.1 13.64 body weighing method 0 12906 321
SS/HsdMcwiCrl body weight to tibia length ratio controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. body mass male 112 days 8 97.84 g/cm 0.03 0.08 body weighing method 0.0 0 67617 735
SS/HsdMcwiCrl both kidneys wet weight to tibia length ratio controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) then controlled protein content diet (33 %) (for 91 days) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. kidney mass male 112 days 7 0.81 g/cm 0.03 0.08 post excision weight measurement 0.0 0 67639 735
SS/HsdMcwiCrl both kidneys wet weight to tibia length ratio controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) then controlled protein content diet (19 %) (for 91 days) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. kidney mass male 112 days 6 0.71 g/cm 0.03 0.07 post excision weight measurement 0.0 0 67642 735
SS/HsdMcwiCrl epididymal fat pad weight to tibia length ratio controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. epididymal fat pad mass male 112 days 8 1.21 g/cm 0.12 0.34 post excision weight measurement 0.0 0 67655 735
SS/HsdMcwiCrl tibia length controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. tibia length male 112 days 8 4.34 cm 0.03 0.08 unspecified method 0.0 0 67613 735
SS/HsdMcwiCrl tibia length controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. tibia length male 112 days 7 4.24 cm 0.01 0.03 unspecified method 0.0 0 67610 735
SS/HsdMcwiCrl urine total protein excretion rate controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. total urine protein amount male 112 days 6 0.6 mg/d 0.1 0.24 bicinchoninic acid protein assay 0.0 0 BCA assay 69612 735
SS/HsdMcwiCrl acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then phenylephrine (2 umol/l) then acetylcholine (3.16 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasodilation trait male 112 days 6 [(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] × 100 100.14 % 0.37 0.91 wire myography mesenteric artery 0.0 0 69619 735
BN/CrlCrlj percentage of study population developing chronic pancreatitis during a period of time controlled protein content diet Tsuji A, et al., Genomics 2001 Jun 15;74(3):365-9. pancreas integrity trait male 120 days 5 0.0 % ex vivo light microscopy 0.0 0 67776 321
SS/HsdMcwiCrl logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then phenylephrine (2 umol/l) then sodium nitroprusside (0.316 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasodilation trait male 112 days 6 logEC50 -7.9 null 0.17 0.42 wire myography mesenteric artery 0.0 0 BCA assay 84650 735
SS/HsdMcwiCrl sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then phenylephrine (1 umol/l) then sodium nitroprusside (3.16 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasodilation trait male 112 days 10 [(maximum PE response − SNP response)/(maximum PE response − baseline before PE constriction)] × 100 96.25 % 1.6 5.06 wire myography aorta 0.0 0 BCA assay 84661 735
SS/HsdMcwiCrl sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then phenylephrine (1 umol/l) then sodium nitroprusside (3.16 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasodilation trait male 112 days 6 [(maximum PE response − SNP response)/(maximum PE response − baseline before PE constriction)] × 100 99.39 % 0.74 1.81 wire myography aorta 0.0 0 BCA assay 84663 735
SS/HsdMcwiCrl logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then phenylephrine (1 umol/l) then sodium nitroprusside (0-9.5 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasodilation trait male 112 days 7 logEC50 -8.37 null 0.13 0.34 wire myography aorta 0.0 0 84670 735
SS/HsdMcwiCrl phenylephrine-induced blood vessel contractile force expressed as percent of force at baseline controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then phenylephrine (31.6 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasoconstriction trait male 112 days 6 [(response to vasoconstrictor - baseline before constriction)/baseline before constriction] x 100 641.52 % 62.37 152.77 wire myography mesenteric artery 0.0 0 phenylephrine-induced blood vessel constriction expressed as percent of force at baseline 84675 735
SS/HsdMcwiCrl phenylephrine-induced blood vessel contractile force expressed as percent of force at baseline controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then NG-nitroarginine methyl ester (100 umol/l) (for 0.2 hours) then phenylephrine (31.6 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasoconstriction trait male 112 days 6 [(response to vasoconstrictor - baseline before constriction)/baseline before constriction] x 100 564.27 % 57.82 141.63 wire myography mesenteric artery 0.0 0 phenylephrine-induced blood vessel constriction expressed as percent of force at baseline 84678 735
SS/HsdMcwiCrl potassium chloride-induced blood vessel contractile force expressed as percent of force at baseline controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then potassium chloride solution (100 mmol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasoconstriction trait male 112 days 10 [(response to vasoconstrictor - baseline before constriction)/baseline before constriction] x 100 301.44 % 27.24 86.14 wire myography mesenteric artery 0.0 0 KCl-induced blood vessel constriction expressed as percent of force at baseline 84681 735
BXH2/Cub both kidneys wet weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. kidney mass male 127 days 18 6.3 g/kg 0.1 0.42 post excision weight measurement 0.0 0 97120 1858
PXO2/Cub blood very low density lipoprotein triglyceride level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood VLDL triglyceride amount male 127 days 11 16.5 mg/dl 1.8 5.97 enzymatic triglyceride assay 0.0 0 97605 1858
PXO4/Cub blood very low density lipoprotein triglyceride level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood VLDL triglyceride amount male 127 days 9 27.6 mg/dl 4.5 13.5 enzymatic triglyceride assay 0.0 0 97611 1858
PXO8-1/Cub epididymal fat pad weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. epididymal fat pad mass male 127 days 10 1.3 % 0.02 0.06 post excision weight measurement 0.0 0 97529 1858
PXO6-3/Cub both kidneys wet weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. kidney mass male 127 days 10 5.9 g/kg 0.1 0.32 post excision weight measurement 0.0 0 97148 1858
PXO3-1/Cub blood total cholesterol level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood cholesterol amount male 127 days 10 53.7 mg/dl 1.3 4.11 enzymatic cholesterol assay 0.0 0 97215 1858
PXO1/Cub blood total cholesterol level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood cholesterol amount male 127 days 11 57.4 mg/dl 1.4 4.64 enzymatic cholesterol assay 0.0 0 97218 1858
BXH2/Cub liver weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. liver mass male 127 days 18 25.2 g/kg 0.2 0.85 post excision weight measurement 0.0 0 97102 1858
SHR.BN-(D8Mit5-D8Mgh6)/Ipcv liver weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. liver mass male 127 days 13 30.6 g/kg 0.3 1.08 post excision weight measurement 0.0 0 97103 1858
PXO5-1/Cub both adrenal glands weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. adrenal gland mass male 127 days 11 14.0 mg/100g 0.5 1.66 post excision weight measurement 0.0 0 97394 1858
PXO4/Cub blood chylomicron cholesterol level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood chylomicron cholesterol amount male 127 days 9 0.03 mg/dl 0.01 0.03 enzymatic cholesterol assay 0.0 0 97350 1858
PXO5-2/Cub blood high density lipoprotein cholesterol level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood HDL cholesterol amount male 127 days 10 32.16 mg/dl 1.52 4.81 enzymatic cholesterol assay 0.0 0 97302 1858
PXO3-1/Cub blood high density lipoprotein cholesterol level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood HDL cholesterol amount male 127 days 10 41.19 mg/dl 1.06 3.35 enzymatic cholesterol assay 0.0 0 97306 1858
PXO8-2/Cub blood high density lipoprotein cholesterol level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood HDL cholesterol amount male 127 days 13 45.31 mg/dl 1.29 4.65 enzymatic cholesterol assay 0.0 0 97309 1858
PXO6-2/Cub blood high density lipoprotein cholesterol level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood HDL cholesterol amount male 127 days 8 46.13 mg/dl 1.76 4.98 enzymatic cholesterol assay 0.0 0 97311 1858
SHR.BN-(D8Mit5-D8Mgh6)/Ipcv blood triglyceride level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood triglyceride amount male 127 days 13 35.6 mg/dl 3.3 11.9 enzymatic triglyceride assay 0.0 0 97321 1858
PXO3-2/Cub blood triglyceride level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood triglyceride amount male 127 days 9 37.4 mg/dl 3.8 11.4 enzymatic triglyceride assay 0.0 0 97322 1858
PXO10/Cub blood very low density lipoprotein particle diameter controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood VLDL particle size male 127 days 12 42.1 nm 0.3 1.04 high-performance liquid chromatography 0.0 0 97670 1858
SHR.BN-(D8Mit5-D8Mgh6)/Ipcv blood glycerol level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood glycerol amount male 127 days 13 4.91 mg/dl 0.23 0.83 enzymatic triglyceride assay 0.0 0 97573 1858
PXO7-1/Cub blood very low density lipoprotein particle diameter controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood VLDL particle size male 127 days 8 39.2 nm 0.2 0.57 high-performance liquid chromatography 0.0 0 97660 1858
PXO6-2/Cub blood very low density lipoprotein particle diameter controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood VLDL particle size male 127 days 8 39.2 nm 0.2 0.57 high-performance liquid chromatography 0.0 0 97661 1858
SHR/Bbb systolic blood pressure controlled protein content diet (19.7 %) (for 28 days) and controlled potassium content diet (6.3 mg/g) (for 28 days) and controlled sodium content diet (3.7 mg/g) (for 28 days) Rubattu S, et al., J Am Heart Assoc. 2016 Feb 17;5(2). pii: e002701. doi: 10.1161/JAHA.115.002701. arterial blood pressure trait not specified 70 days 18 undefined 180.0 mmHg 0.94 4.0 tail cuff plethysmography 0.0 0 97911 1938
PXO5-2/Cub blood very low density lipoprotein triglyceride level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood VLDL triglyceride amount male 127 days 10 66.7 mg/dl 5.8 18.34 enzymatic triglyceride assay 0.0 0 97616 1858
PXO1/Cub blood high density lipoprotein particle diameter controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood HDL particle size male 127 days 11 12.81 nm 0.02 0.07 high-performance liquid chromatography 0.0 0 97706 1858
PXO5-1/Cub heart weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. heart mass male 127 days 11 3.7 g/kg 0.1 0.33 post excision weight measurement 0.0 0 97186 1858
PXO2/Cub heart weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. heart mass male 127 days 11 3.9 g/kg 0.1 0.33 post excision weight measurement 0.0 0 97191 1858
PXO8-1/Cub heart weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. heart mass male 127 days 10 4.2 g/kg 0.3 0.95 post excision weight measurement 0.0 0 97194 1858
PXO5-1/Cub both kidneys wet weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. kidney mass male 127 days 11 5.8 g/kg 0.1 0.33 post excision weight measurement 0.0 0 97126 1858
PXO9/Cub both kidneys wet weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. kidney mass male 127 days 9 6.0 g/kg 0.1 0.3 post excision weight measurement 0.0 0 97150 1858
PXO1/Cub blood low density lipoprotein cholesterol level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood LDL cholesterol amount male 127 days 11 22.37 mg/dl 1.06 3.52 enzymatic cholesterol assay 0.0 0 change to mg/dl when available 97295 1858
PXO7-1/Cub blood high density lipoprotein cholesterol level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood HDL cholesterol amount male 127 days 8 36.57 mg/dl 0.82 2.32 enzymatic cholesterol assay 0.0 0 97305 1858
PXO3-2/Cub liver weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. liver mass male 127 days 9 26.2 g/kg 0.4 1.2 post excision weight measurement 0.0 0 97204 1858
SHRSP/Bbb systolic blood pressure controlled protein content diet (19.7 %) (for 49 days) and controlled potassium content diet (6.3 mg/g) (for 49 days) and controlled sodium content diet (3.7 mg/g) (for 49 days) Rubattu S, et al., J Am Heart Assoc. 2016 Feb 17;5(2). pii: e002701. doi: 10.1161/JAHA.115.002701. arterial blood pressure trait not specified 91 days 5 undefined 193.0 mmHg 6.26 14.0 tail cuff plethysmography 0.0 0 97915 1938
SHR-Ndufc2em1Mcwi+/+ systolic blood pressure controlled protein content diet (19.7 %) (for 56 days) and controlled potassium content diet (6.3 mg/g) (for 56 days) and controlled sodium content diet (3.7 mg/g) (for 56 days) Rubattu S, et al., J Am Heart Assoc. 2016 Feb 17;5(2). pii: e002701. doi: 10.1161/JAHA.115.002701. arterial blood pressure trait not specified 98 days 10 undefined 183.0 mmHg 0.63 2.0 tail cuff plethysmography 0.0 0 97917 1938
SHR-Ndufc2em1Mcwi-/+ systolic blood pressure controlled protein content diet (19.7 %) (for 84 days) and controlled potassium content diet (6.3 mg/g) (for 84 days) and controlled sodium content diet (3.7 mg/g) (for 84 days) Rubattu S, et al., J Am Heart Assoc. 2016 Feb 17;5(2). pii: e002701. doi: 10.1161/JAHA.115.002701. arterial blood pressure trait not specified 126 days 17 undefined 182.0 mmHg 1.7 7.0 tail cuff plethysmography 0.0 0 97921 1938
SHR-Ndufc2em2Mcwi+/+ systolic blood pressure controlled protein content diet (19.7 %) (for 28 days) and controlled potassium content diet (6.3 mg/g) (for 28 days) and controlled sodium content diet (3.7 mg/g) (for 28 days) Rubattu S, et al., J Am Heart Assoc. 2016 Feb 17;5(2). pii: e002701. doi: 10.1161/JAHA.115.002701. arterial blood pressure trait not specified 70 days 12 undefined 181.0 mmHg 0.87 3.0 tail cuff plethysmography 0.0 0 97922 1938
SHRSP/Bbb urine total protein excretion rate controlled protein content diet (19.7 %) (for 49 days) and controlled potassium content diet (6.3 mg/g) (for 49 days) and controlled sodium content diet (3.7 mg/g) (for 49 days) Rubattu S, et al., J Am Heart Assoc. 2016 Feb 17;5(2). pii: e002701. doi: 10.1161/JAHA.115.002701. total urine protein amount not specified 91 days 5 240.0 mg/d 13.42 30.0 urine analysis 0.0 0 97932 1938
SHR-Ndufc2em1Mcwi+/+ urine total protein excretion rate controlled protein content diet (19.7 %) (for 56 days) and controlled potassium content diet (6.3 mg/g) (for 56 days) and controlled sodium content diet (3.7 mg/g) (for 56 days) Rubattu S, et al., J Am Heart Assoc. 2016 Feb 17;5(2). pii: e002701. doi: 10.1161/JAHA.115.002701. total urine protein amount not specified 98 days 10 56.0 mg/d 5.06 16.0 urine analysis 0.0 0 97934 1938
PXO1/Cub blood low density lipoprotein particle diameter controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood LDL particle size male 127 days 11 21.16 nm 0.21 0.7 high-performance liquid chromatography 0.0 0 97684 1858
SHR-Ndufc2em1Mcwi+/+ body weight controlled protein content diet (19.7 %) (for 84 days) and controlled potassium content diet (6.3 mg/g) (for 84 days) and controlled sodium content diet (3.7 mg/g) (for 84 days) Rubattu S, et al., J Am Heart Assoc. 2016 Feb 17;5(2). pii: e002701. doi: 10.1161/JAHA.115.002701. body mass not specified 126 days 10 309.0 g 8.54 27.0 body weighing method 0.0 0 97879 1938
PXO6-3/Cub blood chylomicron triglyceride level controlled sucrose content diet (70 % of calories) (for 7 days) and controlled protein content diet (19.6 % of calories) (for 7 days) and controlled fat content diet (10.4 % of calories) (for 7 days) then fasting (for 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood chylomicron triglyceride amount male 127 days 10 0.2 mg/dl 0.05 0.16 enzymatic triglyceride assay 0.0 0 97581 1858
PXO10/Cub blood chylomicron triglyceride level controlled sucrose content diet (70 % of calories) (for 7 days) and controlled protein content diet (19.6 % of calories) (for 7 days) and controlled fat content diet (10.4 % of calories) (for 7 days) then fasting (for 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood chylomicron triglyceride amount male 127 days 12 0.54 mg/dl 0.13 0.45 enzymatic triglyceride assay 0.0 0 97589 1858
PXO8-1/Cub blood chylomicron triglyceride level controlled sucrose content diet (70 % of calories) (for 7 days) and controlled protein content diet (19.6 % of calories) (for 7 days) and controlled fat content diet (10.4 % of calories) (for 7 days) then fasting (for 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood chylomicron triglyceride amount male 127 days 10 0.85 mg/dl 0.07 0.22 enzymatic triglyceride assay 0.0 0 97591 1858
SHR-Ndufc2em1Mcwi-/+ body weight controlled protein content diet (19.7 %) (for 56 days) and controlled potassium content diet (6.3 mg/g) (for 56 days) and controlled sodium content diet (3.7 mg/g) (for 56 days) Rubattu S, et al., J Am Heart Assoc. 2016 Feb 17;5(2). pii: e002701. doi: 10.1161/JAHA.115.002701. body mass not specified 98 days 17 281.0 g 4.37 18.0 body weighing method 0.0 0 97898 1938
SHR-Ndufc2em2Mcwi+/+ body weight controlled protein content diet (19.7 %) (for 56 days) and controlled potassium content diet (6.3 mg/g) (for 56 days) and controlled sodium content diet (3.7 mg/g) (for 56 days) Rubattu S, et al., J Am Heart Assoc. 2016 Feb 17;5(2). pii: e002701. doi: 10.1161/JAHA.115.002701. body mass not specified 98 days 12 299.0 g 4.62 16.0 body weighing method 0.0 0 97901 1938
SHR-Ndufc2em2Mcwi-/+ body weight controlled protein content diet (19.7 %) (for 56 days) and controlled potassium content diet (6.3 mg/g) (for 56 days) and controlled sodium content diet (3.7 mg/g) (for 56 days) Rubattu S, et al., J Am Heart Assoc. 2016 Feb 17;5(2). pii: e002701. doi: 10.1161/JAHA.115.002701. body mass not specified 98 days 24 293.0 g 6.12 30.0 body weighing method 0.0 0 97904 1938
PXO3-1/Cub blood glycerol level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood glycerol amount male 127 days 10 3.37 mg/dl 0.21 0.66 enzymatic triglyceride assay 0.0 0 97561 1858
PXO6-2/Cub blood glycerol level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood glycerol amount male 127 days 8 4.12 mg/dl 0.21 0.59 enzymatic triglyceride assay 0.0 0 97567 1858
PXO7-1/Cub blood low density lipoprotein particle diameter controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood LDL particle size male 127 days 8 21.44 nm 0.04 0.11 high-performance liquid chromatography 0.0 0 97687 1858
PXO6-3/Cub retroperitoneal fat pad weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. retroperitoneal fat pad mass male 127 days 10 0.49 % 0.02 0.06 post excision weight measurement 0.0 0 97781 1858
PXO5-2/Cub retroperitoneal fat pad weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. retroperitoneal fat pad mass male 127 days 10 0.73 % 0.04 0.13 post excision weight measurement 0.0 0 97783 1858
PXO8-1/Cub both testes wet weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. testis mass male 127 days 10 1.06 % 0.01 0.03 post excision weight measurement 0.0 0 97505 1858
PXO9/Cub epididymal fat pad weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. epididymal fat pad mass male 127 days 9 0.92 % 0.02 0.06 post excision weight measurement 0.0 0 97522 1858
PXO5-2/Cub epididymal fat pad weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. epididymal fat pad mass male 127 days 10 1.26 % 0.02 0.06 post excision weight measurement 0.0 0 97528 1858
PXO5-2/Cub blood very low density lipoprotein particle diameter controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood VLDL particle size male 127 days 10 43.0 nm 0.3 0.95 high-performance liquid chromatography 0.0 0 97675 1858
PXO6-2/Cub blood low density lipoprotein cholesterol level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood LDL cholesterol amount male 127 days 8 13.96 mg/dl 0.76 2.15 enzymatic cholesterol assay 0.0 0 change to mg/dl when available 97288 1858
SHR.BN-(D8Mit5-D8Mgh6)/Ipcv blood low density lipoprotein triglyceride level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood LDL triglyceride amount male 127 days 13 10.2 mg/dl 0.5 1.8 enzymatic triglyceride assay 0.0 0 97619 1858
PXO8-2/Cub blood low density lipoprotein triglyceride level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood LDL triglyceride amount male 127 days 13 17.4 mg/dl 0.8 2.88 enzymatic triglyceride assay 0.0 0 97628 1858
PXO6-2/Cub blood low density lipoprotein triglyceride level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood LDL triglyceride amount male 127 days 8 21.3 mg/dl 1.1 3.11 enzymatic triglyceride assay 0.0 0 97632 1858
PXO10/Cub blood high density lipoprotein triglyceride level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood HDL triglyceride amount male 127 days 12 2.97 mg/dl 0.16 0.55 enzymatic triglyceride assay 0.0 0 97637 1858
PXO3-2/Cub blood high density lipoprotein triglyceride level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood HDL triglyceride amount male 127 days 9 3.68 mg/dl 0.4 1.2 enzymatic triglyceride assay 0.0 0 97641 1858
PXO8-2/Cub blood high density lipoprotein triglyceride level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood HDL triglyceride amount male 127 days 13 4.19 mg/dl 0.25 0.9 enzymatic triglyceride assay 0.0 0 97647 1858
PXO3-2/Cub blood very low density lipoprotein cholesterol level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood VLDL cholesterol amount male 127 days 9 1.52 mg/dl 0.16 0.48 enzymatic cholesterol assay 0.0 0 change to mg/dl when available 97261 1858
PXO6-1/Cub blood chylomicron cholesterol level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood chylomicron cholesterol amount male 127 days 10 0.01 mg/dl 0.0 0.01 enzymatic cholesterol assay 0.0 0 97344 1858
SHRSP/A3NCrl partial pressure of brain white matter oxygen right carotid artery occlusion then controlled protein content diet (16 %) (for 28 days) and controlled sodium content diet (4 %) (for 28 days) and controlled potassium content diet (0.75 %) (for 28 days) and controlled sodium chloride content drinking water (1 %) (for 28 days) Weaver J, etal., J Cereb Blood Flow Metab. 2014 May;34(5):890-6. doi: 10.1038/jcbfm.2014.35. Epub 2014 Feb 19. brain oxygen amount male 112 days 17 13.3 mmHg 1.2 4.95 electron paramagnetic resonance oximetry white matter 40.0 0 5 scans x 40 seconds 107328 3080
SHRSP/A3NCrl brain infarction volume controlled protein content diet (16 %) (between 28 and 120 days) and controlled sodium content diet (4 %) (for 28 days) and controlled potassium content diet (0.75 %) (for 28 days) and unilateral carotid artery occlusion (for 28 days) Yang Y, etal., Neurobiol Dis. 2018 Jun;114:95-110. doi: 10.1016/j.nbd.2018.02.012. Epub 2018 Feb 24. brain integrity trait male 112 days 8 19.7 mm3 4.4 12.45 magnetic resonance imaging corpus callosum 0.0 0 corpus callosum-right hemisphere corpus callosum-right hemisphere 107282 3079
SHRSP/A3NCrl brain infarction volume controlled protein content diet (16 %) (for 63 days) and controlled sodium content diet (4 %) (for 63 days) and controlled potassium content diet (0.75 %) (for 63 days) and unilateral carotid artery occlusion (for 63 days) then dimethyl sulfoxide (30 %) (for 63 days) and Kolliphor HS 15 (25 %) (for 0 hours) Yang Y, etal., Neurobiol Dis. 2018 Jun;114:95-110. doi: 10.1016/j.nbd.2018.02.012. Epub 2018 Feb 24. brain integrity trait male 147 days 8 35.5 mm3 5.7 16.12 magnetic resonance imaging corpus callosum 0.0 0 corpus callosum-right hemisphere corpus callosum-right hemisphere 107288 3079
Crl:SD urine total protein excretion rate controlled protein content diet (20 %) then perindopril (1 mg/kg/d) (for 120 days) Zoja C, etal., Am J Med. 1992 Apr 27;92(4B):60S-63S. doi: 10.1016/0002-9343(92)90149-6. total urine protein amount male 540 days-660 days 8 32.0 mg/d 9.0 25.46 Bradford protein assay 0.0 0 108597 3126
SHRSP/A3NCrl partial pressure of brain white matter oxygen right carotid artery occlusion then controlled protein content diet (16 %) (for 14 days) and controlled sodium content diet (4 %) (for 14 days) and controlled potassium content diet (0.75 %) (for 14 days) and controlled sodium chloride content drinking water (1 %) (for 14 days) Weaver J, etal., J Cereb Blood Flow Metab. 2014 May;34(5):890-6. doi: 10.1038/jcbfm.2014.35. Epub 2014 Feb 19. brain oxygen amount male 98 days 17 15.1 mmHg 1.2 4.95 electron paramagnetic resonance oximetry white matter 40.0 0 5 scans x 40 seconds 107326 3080
SS/HsdMcwiCrl body weight to tibia length ratio controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. body mass male 112 days 9 98.04 g/cm 2.35 7.05 body weighing method 0.0 0 67615 735
SS/HsdMcwiCrl heart weight to tibia length ratio controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. heart mass male 112 days 9 0.34 g/cm 0.01 0.03 post excision weight measurement 0.0 0 67619 735
SS/HsdMcwiCrl epididymal fat pad weight to tibia length ratio controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. epididymal fat pad mass male 112 days 6 1.21 g/cm 0.09 0.22 post excision weight measurement 0.0 0 67654 735
WBN/KobSlc serum insulin level controlled protein content diet (for 120 days) then fasting (for 9 hours) then glucose solution Tsuji A, et al., Genomics 2001 Jun 15;74(3):365-9. blood insulin amount male 120 days 5 0.0 mg/dl 0.0 0.0 oral glucose tolerance test glucose challenge 30 min glucose dose not specified serum glucose 12904 321
SS/HsdMcwiCrl acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) then phenylephrine (2 umol/l) then NG-nitroarginine methyl ester (100 umol/l) (for 0.2 hours) then acetylcholine (3.16 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasodilation trait male 112 days 5 [(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] × 100 94.99 % 0.39 0.87 wire myography mesenteric artery 0.0 0 BCA assay 69620 735
SS/HsdMcwiCrl logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) then phenylephrine (1 umol/l) then sodium nitroprusside (0-9.5 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasodilation trait male 112 days 6 logEC50 -8.08 null 0.11 0.27 wire myography aorta 0.0 0 BCA assay 84668 735
PXO3-1/Cub body weight controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. body mass male 127 days 10 306.3 g 5.1 16.13 body weighing method 0.0 0 97170 1858
PXO7-1/Cub blood high density lipoprotein particle diameter controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood HDL particle size male 127 days 8 12.35 nm 0.02 0.06 high-performance liquid chromatography 0.0 0 97694 1858
PXO6-2/Cub blood chylomicron triglyceride level controlled sucrose content diet (70 % of calories) (for 7 days) and controlled protein content diet (19.6 % of calories) (for 7 days) and controlled fat content diet (10.4 % of calories) (for 7 days) then fasting (for 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood chylomicron triglyceride amount male 127 days 8 0.27 mg/dl 0.09 0.25 enzymatic triglyceride assay 0.0 0 97582 1858
PXO8-2/Cub blood very low density lipoprotein triglyceride level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood VLDL triglyceride amount male 127 days 13 36.9 mg/dl 4.0 14.42 enzymatic triglyceride assay 0.0 0 97614 1858
SHR.BN-(D8Mit5-D8Mgh6)/Ipcv blood low density lipoprotein particle diameter controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood LDL particle size male 127 days 13 20.64 nm 0.05 0.18 high-performance liquid chromatography 0.0 0 97678 1858
PXO3-1/Cub blood high density lipoprotein particle diameter controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood HDL particle size male 127 days 10 12.71 nm 0.02 0.06 high-performance liquid chromatography 0.0 0 97703 1858
SHR.BN-(D8Mit5-D8Mgh6)/Ipcv blood high density lipoprotein particle diameter controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood HDL particle size male 127 days 13 13.0 nm 0.03 0.11 high-performance liquid chromatography 0.0 0 97708 1858
PXO7-1/Cub heart weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. heart mass male 127 days 8 3.3 g/kg 0.1 0.28 post excision weight measurement 0.0 0 97182 1858
PXO8-2/Cub blood high density lipoprotein particle diameter controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood HDL particle size male 127 days 13 12.65 nm 0.03 0.11 high-performance liquid chromatography 0.0 0 97701 1858
BXH2/Cub epididymal fat pad weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. epididymal fat pad mass male 127 days 18 1.04 % 0.02 0.08 post excision weight measurement 0.0 0 97524 1858
PXO6-3/Cub blood total cholesterol level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood cholesterol amount male 127 days 10 56.0 mg/dl 1.6 5.06 enzymatic cholesterol assay 0.0 0 97217 1858
SHR.BN-(D8Mit5-D8Mgh6)/Ipcv blood chylomicron cholesterol level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood chylomicron cholesterol amount male 127 days 13 0.07 mg/dl 0.01 0.04 enzymatic cholesterol assay 0.0 0 97353 1858
PXO2/Cub blood chylomicron cholesterol level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood chylomicron cholesterol amount male 127 days 11 0.17 mg/dl 0.03 0.1 enzymatic cholesterol assay 0.0 0 97359 1858
PXO9/Cub blood very low density lipoprotein particle diameter controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood VLDL particle size male 127 days 9 42.5 nm 0.2 0.6 high-performance liquid chromatography 0.0 0 97672 1858
SHR-Ndufc2em2Mcwi+/+ urine total protein excretion rate controlled protein content diet (19.7 %) (for 56 days) and controlled potassium content diet (6.3 mg/g) (for 56 days) and controlled sodium content diet (3.7 mg/g) (for 56 days) Rubattu S, et al., J Am Heart Assoc. 2016 Feb 17;5(2). pii: e002701. doi: 10.1161/JAHA.115.002701. total urine protein amount not specified 98 days 12 47.0 mg/d 7.51 26.0 urine analysis 0.0 0 97940 1938
SHR-Ndufc2em2Mcwi-/+ urine total protein excretion rate controlled protein content diet (19.7 %) (for 56 days) and controlled potassium content diet (6.3 mg/g) (for 56 days) and controlled sodium content diet (3.7 mg/g) (for 56 days) Rubattu S, et al., J Am Heart Assoc. 2016 Feb 17;5(2). pii: e002701. doi: 10.1161/JAHA.115.002701. total urine protein amount not specified 98 days 24 146.0 mg/d 11.84 58.0 urine analysis 0.0 0 97943 1938
PXO6-1/Cub both testes wet weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. testis mass male 127 days 10 1.14 % 0.04 0.13 post excision weight measurement 0.0 0 97510 1858
PXO6-2/Cub epididymal fat pad weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. epididymal fat pad mass male 127 days 8 0.87 % 0.03 0.08 post excision weight measurement 0.0 0 97515 1858
WBN/KobSlc blood glucose level controlled protein content diet (for 120 days) then fasting (for 9 hours) Tsuji A, et al., Genomics 2001 Jun 15;74(3):365-9. blood glucose amount male 120 days 5 140.2 mg/dl 13.4 29.96 oral glucose tolerance test glucose challenge 0 min serum glucose WBN/Kob rats were studied as a model of pancreatitis and diabetes mellitus 12887 321
SS/HsdMcwiCrl heart weight to tibia length ratio controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) then controlled protein content diet (33 %) (for 91 days) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. heart mass male 112 days 7 0.37 g/cm 0.02 0.05 post excision weight measurement 0.0 0 67618 735
SS/HsdMcwiCrl food intake rate controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. eating behavior trait male 112 days 7 20.9 g/d 1.4 3.7 unspecified method 0.0 0 67661 735
SS/HsdMcwiCrl water drink intake rate controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. drinking behavior trait male 112 days 8 30.1 ml/d 1.8 5.09 unspecified method 0.0 0 67663 735
SS/HsdMcwiCrl water drink intake rate controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. drinking behavior trait male 112 days 9 21.8 ml/d 1.6 4.8 unspecified method 0.0 0 67664 735
SS/HsdMcwiCrl water drink intake rate controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. drinking behavior trait male 112 days 5 30.1 ml/d 0.8 1.79 unspecified method 0.0 0 67666 735
SS/HsdMcwiCrl urine sodium excretion rate controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. urine sodium amount male 112 days 7 9.0 mEq/d 1.3 3.44 automated urine analysis 0.0 0 67669 735
SS/HsdMcwiCrl acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then phenylephrine (2 umol/l) then sodium nitroprusside (0.316 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasodilation trait male 112 days 7 [(maximum PE response − SNP response)/(maximum PE response − baseline before PE constriction)] × 100 98.24 % 0.82 2.17 wire myography mesenteric artery 0.0 0 BCA assay 67673 735
SS/HsdMcwiCrl sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then phenylephrine (2 umol/l) then sodium nitroprusside (0.316 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasodilation trait male 112 days 6 [(maximum PE response − SNP response)/(maximum PE response − baseline before PE constriction)] × 100 98.54 % 0.51 1.25 wire myography mesenteric artery 0.0 0 BCA assay 67674 735
SS/HsdMcwiCrl body weight to tibia length ratio controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. body mass male 112 days 7 100.21 g/cm 1.76 4.66 body weighing method 0.0 0 67614 735
WBN/KobSlc percentage of study population developing chronic pancreatitis during a period of time controlled protein content diet Tsuji A, et al., Genomics 2001 Jun 15;74(3):365-9. pancreas integrity trait male 90 days 13 69.0 % ex vivo light microscopy 0.0 0 67772 321
BN/CrlCrlj percentage of study population developing chronic pancreatitis during a period of time controlled protein content diet Tsuji A, et al., Genomics 2001 Jun 15;74(3):365-9. pancreas integrity trait male 90 days 5 0.0 % ex vivo light microscopy 0.0 0 67773 321
SS/HsdMcwiCrl logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then phenylephrine (2 umol/l) then acetylcholine (0.001-9.5 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasodilation trait male 112 days 6 logEC50 -7.2 null 0.1 0.24 wire myography mesenteric artery 0.0 0 84643 735
SS/HsdMcwiCrl logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) then phenylephrine (2 umol/l) then NG-nitroarginine methyl ester (100 umol/l) (for 0.2 hours) then acetylcholine (0.001-9.5 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasodilation trait male 112 days 5 logEC50 -6.2 null 0.1 0.22 wire myography mesenteric artery 0.0 0 BCA assay 84644 735
SS/HsdMcwiCrl logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then phenylephrine (2 umol/l) then NG-nitroarginine methyl ester (100 umol/l) then acetylcholine (0.001-9.5 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasodilation trait male 112 days 5 logEC50 -6.7 null 0.2 0.45 wire myography mesenteric artery 0.0 0 84647 735
SS/HsdMcwiCrl logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then phenylephrine (2 umol/l) then sodium nitroprusside (0.316 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasodilation trait male 112 days 10 logEC50 -8.0 null 0.09 0.28 wire myography mesenteric artery 0.0 0 BCA assay 84649 735
BN ratio of apoptotic bodies to intact tumor cells in nonremodelling liver tumorous lesions N-nitrosodiethylamine (150 mg/kg) then controlled protein content diet (for 15 days) and controlled 2-acetamidofluorene content diet (0.02 %) then partial hepatectomy De Miglio MR, et al., Int J Cancer 2003 May 20;105(1):70-5. liver integrity trait not specified 0 days 0 1.55 % 0.09 ex vivo light microscopy with immunohistochemistry and digital image analysis 0.0 0 84780 1603
BN ratio of apoptotic bodies to intact tumor cells in remodelling liver tumorous lesions N-nitrosodiethylamine (150 mg/kg) then controlled protein content diet (for 15 days) and controlled 2-acetamidofluorene content diet (0.02 %) then partial hepatectomy De Miglio MR, et al., Int J Cancer 2003 May 20;105(1):70-5. liver integrity trait not specified 0 days 0 2.08 % 0.18 ex vivo light microscopy with immunohistochemistry and digital image analysis 0.0 0 84783 1603
SS/HsdMcwiCrl phenylephrine-induced blood vessel contractile force expressed as percent of force at baseline controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) then phenylephrine (31.6 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasoconstriction trait male 112 days 7 [(response to vasoconstrictor - baseline before constriction)/baseline before constriction] x 100 694.94 % 34.53 91.36 wire myography mesenteric artery 0.0 0 phenylephrine-induced blood vessel constriction expressed as percent of force at baseline 84672 735
PXO7-1/Cub both testes wet weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. testis mass male 127 days 8 1.25 % 0.01 0.03 post excision weight measurement 0.0 0 97513 1858
BXH2/Cub both testes wet weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. testis mass male 127 days 18 1.3 % 0.03 0.13 post excision weight measurement 0.0 0 97514 1858
PXO4/Cub epididymal fat pad weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. epididymal fat pad mass male 127 days 9 0.87 % 0.02 0.06 post excision weight measurement 0.0 0 97516 1858
PXO6-1/Cub blood low density lipoprotein cholesterol level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood LDL cholesterol amount male 127 days 10 10.95 mg/dl 0.71 2.25 enzymatic cholesterol assay 0.0 0 change to mg/dl when available 97283 1858
PXO7-1/Cub blood triglyceride level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood triglyceride amount male 127 days 8 51.9 mg/dl 3.6 10.18 enzymatic triglyceride assay 0.0 0 97326 1858
PXO3-1/Cub blood low density lipoprotein triglyceride level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood LDL triglyceride amount male 127 days 10 8.0 mg/dl 0.3 0.95 enzymatic triglyceride assay 0.0 0 97618 1858
PXO9/Cub blood low density lipoprotein triglyceride level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood LDL triglyceride amount male 127 days 9 10.2 mg/dl 0.9 2.7 enzymatic triglyceride assay 0.0 0 97620 1858
PXO2/Cub blood low density lipoprotein triglyceride level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood LDL triglyceride amount male 127 days 11 11.3 mg/dl 0.5 1.66 enzymatic triglyceride assay 0.0 0 97622 1858
PXO5-1/Cub blood low density lipoprotein triglyceride level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood LDL triglyceride amount male 127 days 11 16.2 mg/dl 0.6 1.99 enzymatic triglyceride assay 0.0 0 97625 1858
PXO5-2/Cub blood low density lipoprotein triglyceride level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood LDL triglyceride amount male 127 days 10 16.6 mg/dl 0.9 2.85 enzymatic triglyceride assay 0.0 0 97626 1858
PXO6-3/Cub blood low density lipoprotein triglyceride level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood LDL triglyceride amount male 127 days 10 17.6 mg/dl 0.3 0.95 enzymatic triglyceride assay 0.0 0 97629 1858
PXO7-1/Cub blood low density lipoprotein triglyceride level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood LDL triglyceride amount male 127 days 8 20.0 mg/dl 0.8 2.26 enzymatic triglyceride assay 0.0 0 97631 1858
PXO6-1/Cub blood high density lipoprotein triglyceride level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood HDL triglyceride amount male 127 days 10 2.86 mg/dl 0.24 0.76 enzymatic triglyceride assay 0.0 0 97635 1858
PXO2/Cub blood high density lipoprotein triglyceride level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood HDL triglyceride amount male 127 days 11 3.2 mg/dl 0.27 0.9 enzymatic triglyceride assay 0.0 0 97639 1858
PXO7-1/Cub blood high density lipoprotein triglyceride level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood HDL triglyceride amount male 127 days 8 3.71 mg/dl 0.13 0.37 enzymatic triglyceride assay 0.0 0 97642 1858
PXO6-2/Cub blood high density lipoprotein triglyceride level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood HDL triglyceride amount male 127 days 8 3.72 mg/dl 0.13 0.37 enzymatic triglyceride assay 0.0 0 97643 1858
PXO6-3/Cub blood high density lipoprotein triglyceride level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood HDL triglyceride amount male 127 days 10 4.31 mg/dl 0.18 0.57 enzymatic triglyceride assay 0.0 0 97648 1858
PXO6-2/Cub blood very low density lipoprotein cholesterol level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood VLDL cholesterol amount male 127 days 8 1.58 mg/dl 0.2 0.57 enzymatic cholesterol assay 0.0 0 change to mg/dl when available 97262 1858
PXO8-2/Cub blood very low density lipoprotein cholesterol level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood VLDL cholesterol amount male 127 days 13 3.68 mg/dl 0.31 1.12 enzymatic cholesterol assay 0.0 0 change to mg/dl when available 97267 1858
PXO5-1/Cub blood very low density lipoprotein cholesterol level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood VLDL cholesterol amount male 127 days 11 6.31 mg/dl 0.45 1.49 enzymatic cholesterol assay 0.0 0 change to mg/dl when available 97270 1858
PXO1/Cub blood very low density lipoprotein cholesterol level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood VLDL cholesterol amount male 127 days 11 7.32 mg/dl 1.11 3.68 enzymatic cholesterol assay 0.0 0 change to mg/dl when available 97273 1858
PXO2/Cub both testes wet weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. testis mass male 127 days 11 0.77 % 0.05 0.17 post excision weight measurement 0.0 0 97341 1858
PXO6-1/Cub retroperitoneal fat pad weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. retroperitoneal fat pad mass male 127 days 10 0.35 % 0.02 0.06 post excision weight measurement 0.0 0 97343 1858
PXO8-2/Cub blood chylomicron triglyceride level controlled sucrose content diet (70 % of calories) (for 7 days) and controlled protein content diet (19.6 % of calories) (for 7 days) and controlled fat content diet (10.4 % of calories) (for 7 days) then fasting (for 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood chylomicron triglyceride amount male 127 days 13 0.84 mg/dl 0.11 0.4 enzymatic triglyceride assay 0.0 0 97590 1858
PXO3-2/Cub blood very low density lipoprotein particle diameter controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood VLDL particle size male 127 days 9 39.5 nm 0.3 0.9 high-performance liquid chromatography 0.0 0 97663 1858
PXO3-1/Cub blood very low density lipoprotein triglyceride level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood VLDL triglyceride amount male 127 days 10 16.5 mg/dl 1.0 3.16 enzymatic triglyceride assay 0.0 0 97606 1858
PXO9/Cub blood very low density lipoprotein triglyceride level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood VLDL triglyceride amount male 127 days 9 17.4 mg/dl 2.2 6.6 enzymatic triglyceride assay 0.0 0 97607 1858
PXO7-1/Cub epididymal fat pad weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. epididymal fat pad mass male 127 days 8 0.98 % 0.06 0.17 post excision weight measurement 0.0 0 97523 1858
PXO6-1/Cub blood total cholesterol level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood cholesterol amount male 127 days 10 42.9 mg/dl 1.7 5.38 enzymatic cholesterol assay 0.0 0 97210 1858
PXO6-1/Cub blood very low density lipoprotein particle diameter controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood VLDL particle size male 127 days 10 38.6 nm 0.4 1.26 high-performance liquid chromatography 0.0 0 97657 1858
PXO8-1/Cub blood low density lipoprotein cholesterol level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood LDL cholesterol amount male 127 days 10 12.56 mg/dl 0.61 1.93 enzymatic cholesterol assay 0.0 0 change to mg/dl when available 97287 1858
PXO8-2/Cub both adrenal glands weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. adrenal gland mass male 127 days 13 12.0 mg/100g 0.4 1.44 post excision weight measurement 0.0 0 97390 1858
SHR-Ndufc2em1Mcwi+/+ body weight controlled protein content diet (19.7 %) (for 56 days) and controlled potassium content diet (6.3 mg/g) (for 56 days) and controlled sodium content diet (3.7 mg/g) (for 56 days) Rubattu S, et al., J Am Heart Assoc. 2016 Feb 17;5(2). pii: e002701. doi: 10.1161/JAHA.115.002701. body mass not specified 98 days 10 287.0 g 3.79 12.0 body weighing method 0.0 0 97878 1938
PXO5-1/Cub blood very low density lipoprotein triglyceride level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood VLDL triglyceride amount male 127 days 11 64.7 mg/dl 6.1 20.23 enzymatic triglyceride assay 0.0 0 97615 1858
PXO6-1/Cub blood high density lipoprotein particle diameter controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood HDL particle size male 127 days 10 12.12 nm 0.02 0.06 high-performance liquid chromatography 0.0 0 97692 1858
BXH2/Cub body weight controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. body mass male 127 days 18 194.0 g 3.0 12.73 body weighing method 0.0 0 97100 1858
PXO3-2/Cub heart weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. heart mass male 127 days 9 3.1 g/kg 0.1 0.3 post excision weight measurement 0.0 0 97180 1858
PXO10/Cub heart weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. heart mass male 127 days 12 3.4 g/kg 0.1 0.35 post excision weight measurement 0.0 0 97183 1858
PXO2/Cub blood low density lipoprotein particle diameter controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood LDL particle size male 127 days 11 21.2 nm 0.17 0.56 high-performance liquid chromatography 0.0 0 97685 1858
PXO4/Cub blood high density lipoprotein particle diameter controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood HDL particle size male 127 days 9 12.7 nm 0.02 0.06 high-performance liquid chromatography 0.0 0 97702 1858
PXO6-1/Cub body weight controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. body mass male 127 days 10 251.2 g 5.5 17.39 body weighing method 0.0 0 97162 1858
PXO8-1/Cub blood low density lipoprotein particle diameter controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood LDL particle size male 127 days 10 21.07 nm 0.1 0.32 high-performance liquid chromatography 0.0 0 97682 1858
PXO5-1/Cub blood triglyceride level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood triglyceride amount male 127 days 11 88.8 mg/dl 6.8 22.55 enzymatic triglyceride assay 0.0 0 97329 1858
BXH2/Cub retroperitoneal fat pad weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. retroperitoneal fat pad mass male 127 days 18 0.41 % 0.03 0.13 post excision weight measurement 0.0 0 97777 1858
PXO5-1/Cub liver weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. liver mass male 127 days 11 25.5 g/kg 0.2 0.66 post excision weight measurement 0.0 0 97201 1858
SHRSP/Bbb systolic blood pressure controlled protein content diet (19.7 %) (for 28 days) and controlled potassium content diet (6.3 mg/g) (for 28 days) and controlled sodium content diet (3.7 mg/g) (for 28 days) Rubattu S, et al., J Am Heart Assoc. 2016 Feb 17;5(2). pii: e002701. doi: 10.1161/JAHA.115.002701. arterial blood pressure trait not specified 70 days 18 undefined 181.0 mmHg 3.3 14.0 tail cuff plethysmography 0.0 0 97914 1938
SHR-Ndufc2em1Mcwi+/+ systolic blood pressure controlled protein content diet (19.7 %) (for 28 days) and controlled potassium content diet (6.3 mg/g) (for 28 days) and controlled sodium content diet (3.7 mg/g) (for 28 days) Rubattu S, et al., J Am Heart Assoc. 2016 Feb 17;5(2). pii: e002701. doi: 10.1161/JAHA.115.002701. arterial blood pressure trait not specified 70 days 10 undefined 177.0 mmHg 2.21 7.0 tail cuff plethysmography 0.0 0 97916 1938
SHR-Ndufc2em1Mcwi-/+ systolic blood pressure controlled protein content diet (19.7 %) (for 28 days) and controlled potassium content diet (6.3 mg/g) (for 28 days) and controlled sodium content diet (3.7 mg/g) (for 28 days) Rubattu S, et al., J Am Heart Assoc. 2016 Feb 17;5(2). pii: e002701. doi: 10.1161/JAHA.115.002701. arterial blood pressure trait not specified 70 days 17 undefined 174.0 mmHg 1.46 6.0 tail cuff plethysmography 0.0 0 97919 1938
SHR-Ndufc2em2Mcwi+/+ systolic blood pressure controlled protein content diet (19.7 %) (for 56 days) and controlled potassium content diet (6.3 mg/g) (for 56 days) and controlled sodium content diet (3.7 mg/g) (for 56 days) Rubattu S, et al., J Am Heart Assoc. 2016 Feb 17;5(2). pii: e002701. doi: 10.1161/JAHA.115.002701. arterial blood pressure trait not specified 98 days 12 undefined 181.0 mmHg 2.6 9.0 tail cuff plethysmography 0.0 0 97923 1938
SHR-Ndufc2em2Mcwi+/+ systolic blood pressure controlled protein content diet (19.7 %) (for 84 days) and controlled potassium content diet (6.3 mg/g) (for 84 days) and controlled sodium content diet (3.7 mg/g) (for 84 days) Rubattu S, et al., J Am Heart Assoc. 2016 Feb 17;5(2). pii: e002701. doi: 10.1161/JAHA.115.002701. arterial blood pressure trait not specified 126 days 12 undefined 190.0 mmHg 0.87 3.0 tail cuff plethysmography 0.0 0 97924 1938
SHR-Ndufc2em2Mcwi-/+ systolic blood pressure controlled protein content diet (19.7 %) (for 56 days) and controlled potassium content diet (6.3 mg/g) (for 56 days) and controlled sodium content diet (3.7 mg/g) (for 56 days) Rubattu S, et al., J Am Heart Assoc. 2016 Feb 17;5(2). pii: e002701. doi: 10.1161/JAHA.115.002701. arterial blood pressure trait not specified 98 days 24 undefined 189.0 mmHg 0.41 2.0 tail cuff plethysmography 0.0 0 97926 1938
SHRSP/Bbb urine total protein excretion rate controlled protein content diet (19.7 %) (for 28 days) and controlled potassium content diet (6.3 mg/g) (for 28 days) and controlled sodium content diet (3.7 mg/g) (for 28 days) Rubattu S, et al., J Am Heart Assoc. 2016 Feb 17;5(2). pii: e002701. doi: 10.1161/JAHA.115.002701. total urine protein amount not specified 70 days 18 188.0 mg/d 2.83 12.0 urine analysis 0.0 0 97931 1938
SHR-Ndufc2em2Mcwi+/+ urine total protein excretion rate controlled protein content diet (19.7 %) (for 28 days) and controlled potassium content diet (6.3 mg/g) (for 28 days) and controlled sodium content diet (3.7 mg/g) (for 28 days) Rubattu S, et al., J Am Heart Assoc. 2016 Feb 17;5(2). pii: e002701. doi: 10.1161/JAHA.115.002701. total urine protein amount not specified 70 days 12 31.0 mg/d 1.44 5.0 urine analysis 0.0 0 97939 1938
SHR-Ndufc2em2Mcwi-/+ urine total protein excretion rate controlled protein content diet (19.7 %) (for 84 days) and controlled potassium content diet (6.3 mg/g) (for 84 days) and controlled sodium content diet (3.7 mg/g) (for 84 days) Rubattu S, et al., J Am Heart Assoc. 2016 Feb 17;5(2). pii: e002701. doi: 10.1161/JAHA.115.002701. total urine protein amount not specified 126 days 16 126.0 mg/d 6.75 27.0 urine analysis 0.0 0 97944 1938
PXO10/Cub blood chylomicron cholesterol level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood chylomicron cholesterol amount male 127 days 12 0.12 mg/dl 0.02 0.07 enzymatic cholesterol assay 0.0 0 97355 1858
BXH2/Cub blood chylomicron cholesterol level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood chylomicron cholesterol amount male 127 days 18 0.16 mg/dl 0.04 0.17 enzymatic cholesterol assay 0.0 0 97358 1858
PXO9/Cub blood triglyceride level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood triglyceride amount male 127 days 9 31.0 mg/dl 3.1 9.3 enzymatic triglyceride assay 0.0 0 97318 1858
PXO2/Cub blood triglyceride level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood triglyceride amount male 127 days 11 31.9 mg/dl 2.2 7.3 enzymatic triglyceride assay 0.0 0 97319 1858
PXO8-1/Cub blood triglyceride level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood triglyceride amount male 127 days 10 50.7 mg/dl 3.8 12.02 enzymatic triglyceride assay 0.0 0 97325 1858
PXO7-1/Cub liver weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. liver mass male 127 days 8 27.3 g/kg 0.3 0.85 post excision weight measurement 0.0 0 97208 1858
PXO6-1/Cub both adrenal glands weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. adrenal gland mass male 127 days 10 20.0 mg/100g 0.6 1.9 post excision weight measurement 0.0 0 97407 1858
PXO6-1/Cub liver weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. liver mass male 127 days 10 23.8 g/kg 0.3 0.95 post excision weight measurement 0.0 0 97196 1858
PXO5-1/Cub blood very low density lipoprotein particle diameter controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood VLDL particle size male 127 days 11 41.5 nm 0.3 0.99 high-performance liquid chromatography 0.0 0 97669 1858
PXO1/Cub blood very low density lipoprotein particle diameter controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood VLDL particle size male 127 days 11 42.2 nm 0.3 0.99 high-performance liquid chromatography 0.0 0 97671 1858
SHR/Bbb systolic blood pressure controlled protein content diet (19.7 %) (for 84 days) and controlled potassium content diet (6.3 mg/g) (for 84 days) and controlled sodium content diet (3.7 mg/g) (for 84 days) Rubattu S, et al., J Am Heart Assoc. 2016 Feb 17;5(2). pii: e002701. doi: 10.1161/JAHA.115.002701. arterial blood pressure trait not specified 126 days 18 undefined 188.0 mmHg 0.94 4.0 tail cuff plethysmography 0.0 0 97913 1938
PXO9/Cub body weight controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. body mass male 127 days 9 245.0 g 6.2 18.6 body weighing method 0.0 0 97160 1858
PXO10/Cub body weight controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. body mass male 127 days 12 295.6 g 7.2 24.94 body weighing method 0.0 0 97168 1858
PXO5-2/Cub blood high density lipoprotein particle diameter controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood HDL particle size male 127 days 10 12.45 nm 0.04 0.13 high-performance liquid chromatography 0.0 0 97697 1858
PXO10/Cub blood high density lipoprotein particle diameter controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood HDL particle size male 127 days 12 12.73 nm 0.03 0.1 high-performance liquid chromatography 0.0 0 97704 1858
PXO1/Cub blood chylomicron triglyceride level controlled sucrose content diet (70 % of calories) (for 7 days) and controlled protein content diet (19.6 % of calories) (for 7 days) and controlled fat content diet (10.4 % of calories) (for 7 days) then fasting (for 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood chylomicron triglyceride amount male 127 days 11 1.16 mg/dl 0.16 0.53 enzymatic triglyceride assay 0.0 0 97594 1858
SHR-Ndufc2em2Mcwi-/+ body weight controlled protein content diet (19.7 %) (for 84 days) and controlled potassium content diet (6.3 mg/g) (for 84 days) and controlled sodium content diet (3.7 mg/g) (for 84 days) Rubattu S, et al., J Am Heart Assoc. 2016 Feb 17;5(2). pii: e002701. doi: 10.1161/JAHA.115.002701. body mass not specified 126 days 16 312.0 g 9.0 36.0 body weighing method 0.0 0 97905 1938
SHRSP/Bbb body weight controlled protein content diet (19.7 %) (for 28 days) and controlled potassium content diet (6.3 mg/g) (for 28 days) and controlled sodium content diet (3.7 mg/g) (for 28 days) Rubattu S, et al., J Am Heart Assoc. 2016 Feb 17;5(2). pii: e002701. doi: 10.1161/JAHA.115.002701. body mass not specified 70 days 18 177.0 g 1.41 6.0 body weighing method 0.0 0 97909 1938
PXO1/Cub blood glycerol level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood glycerol amount male 127 days 11 3.73 mg/dl 0.22 0.73 enzymatic triglyceride assay 0.0 0 97563 1858
BXH2/Cub blood glycerol level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood glycerol amount male 127 days 18 4.18 mg/dl 0.19 0.81 enzymatic triglyceride assay 0.0 0 97568 1858
PXO6-3/Cub blood high density lipoprotein particle diameter controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood HDL particle size male 127 days 10 12.43 nm 0.06 0.19 high-performance liquid chromatography 0.0 0 97696 1858
BXH2/Cub blood high density lipoprotein particle diameter controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood HDL particle size male 127 days 18 12.57 nm 0.06 0.25 high-performance liquid chromatography 0.0 0 97699 1858
PXO3-2/Cub retroperitoneal fat pad weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. retroperitoneal fat pad mass male 127 days 9 0.48 % 0.04 0.12 post excision weight measurement 0.0 0 97780 1858
PXO2/Cub retroperitoneal fat pad weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. retroperitoneal fat pad mass male 127 days 11 1.12 % 0.05 0.17 post excision weight measurement 0.0 0 97791 1858
Crl:SD systolic blood pressure controlled protein content diet (20 %) then perindopril (1 mg/kg/d) (for 120 days) Zoja C, etal., Am J Med. 1992 Apr 27;92(4B):60S-63S. doi: 10.1016/0002-9343(92)90149-6. arterial blood pressure trait male 540 days-660 days 8 130.0 mmHg 7.0 19.8 tail cuff plethysmography tail 0.0 0 108594 3126
Crl:SD urine total protein excretion rate controlled protein content diet (20 %) Zoja C, etal., Am J Med. 1992 Apr 27;92(4B):60S-63S. doi: 10.1016/0002-9343(92)90149-6. total urine protein amount male 420 days-540 days 8 61.0 mg/d 11.0 31.11 Bradford protein assay 0.0 0 108598 3126
SHRSP/A3NCrl partial pressure of brain white matter oxygen right carotid artery occlusion then controlled protein content diet (16 %) (for 7 days) and controlled sodium content diet (4 %) (for 7 days) and controlled potassium content diet (0.75 %) (for 7 days) and controlled sodium chloride content drinking water (1 %) (for 7 days) Weaver J, etal., J Cereb Blood Flow Metab. 2014 May;34(5):890-6. doi: 10.1038/jcbfm.2014.35. Epub 2014 Feb 19. brain oxygen amount male 91 days 17 19.5 mmHg 1.2 4.95 electron paramagnetic resonance oximetry white matter 40.0 0 5 scans x 40 seconds 107325 3080
WBN/KobSlc blood glucose level controlled protein content diet (for 120 days) then fasting (for 9 hours) then glucose solution Tsuji A, et al., Genomics 2001 Jun 15;74(3):365-9. blood glucose amount male 120 days 5 216.9 mg/dl 8.6 19.23 oral glucose tolerance test glucose challenge 120 min glucose dose not specified serum glucose WBN/Kob rats were studied as a model of pancreatitis and diabetes mellitus 12896 321
BN/CrlCrlj body weight controlled protein content diet Tsuji A, et al., Genomics 2001 Jun 15;74(3):365-9. body mass male 120 days 5 248.0 g 4.3 9.62 body weighing method 0 12913 321
SS/HsdMcwiCrl acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) then phenylephrine (1 umol/l) then NG-nitroarginine methyl ester (100 umol/l) (for 0.2 hours) then acetylcholine (31.6 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasodilation trait male 112 days 6 [(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] × 100 -19.03 % 4.01 9.82 wire myography aorta 0.0 0 BCA assay 84656 735
SS/HsdMcwiCrl logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then phenylephrine (1 umol/l) then sodium nitroprusside (0-9.5 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasodilation trait male 112 days 6 logEC50 -8.24 null 0.13 0.32 wire myography aorta 0.0 0 84671 735
SS/HsdMcwiCrl phenylephrine-induced blood vessel contractile force expressed as percent of force at baseline controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) then NG-nitroarginine methyl ester (100 umol/l) (for 0.2 hours) then phenylephrine (31.6 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasoconstriction trait male 112 days 7 [(response to vasoconstrictor - baseline before constriction)/baseline before constriction] x 100 756.89 % 61.56 162.87 wire myography mesenteric artery 0.0 0 phenylephrine-induced blood vessel constriction expressed as percent of force at baseline 84676 735
PXO2/Cub body weight controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. body mass male 127 days 11 270.2 g 4.7 15.59 body weighing method 0.0 0 97164 1858
PXO8-2/Cub body weight controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. body mass male 127 days 13 291.4 g 4.8 17.31 body weighing method 0.0 0 97167 1858
PXO9/Cub blood chylomicron triglyceride level controlled sucrose content diet (70 % of calories) (for 7 days) and controlled protein content diet (19.6 % of calories) (for 7 days) and controlled fat content diet (10.4 % of calories) (for 7 days) then fasting (for 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood chylomicron triglyceride amount male 127 days 9 0.54 mg/dl 0.11 0.33 enzymatic triglyceride assay 0.0 0 97588 1858
PXO10/Cub blood very low density lipoprotein triglyceride level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood VLDL triglyceride amount male 127 days 13 12.6 mg/dl 2.0 7.21 enzymatic triglyceride assay 0.0 0 97601 1858
PXO1/Cub heart weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. heart mass male 127 days 11 3.5 g/kg 0.2 0.66 post excision weight measurement 0.0 0 97184 1858
PXO4/Cub heart weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. heart mass male 127 days 9 3.7 g/kg 0.1 0.3 post excision weight measurement 0.0 0 97187 1858
PXO7-1/Cub body weight controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. body mass male 127 days 8 250.9 g 3.8 10.75 body weighing method 0.0 0 97161 1858
PXO6-2/Cub both kidneys wet weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. kidney mass male 127 days 8 5.6 g/kg 0.1 0.28 post excision weight measurement 0.0 0 97124 1858
PXO7-1/Cub both kidneys wet weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. kidney mass male 127 days 8 5.8 g/kg 0.1 0.28 post excision weight measurement 0.0 0 97127 1858
PXO1/Cub both kidneys wet weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. kidney mass male 127 days 11 5.9 g/kg 0.1 0.33 post excision weight measurement 0.0 0 97149 1858
PXO10/Cub both kidneys wet weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. kidney mass male 127 days 12 7.3 g/kg 0.1 0.35 post excision weight measurement 0.0 0 97155 1858
PXO2/Cub blood low density lipoprotein cholesterol level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood LDL cholesterol amount male 127 days 11 22.72 mg/dl 0.93 3.08 enzymatic cholesterol assay 0.0 0 change to mg/dl when available 97296 1858
PXO8-2/Cub liver weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. liver mass male 127 days 13 25.3 g/kg 0.2 0.72 post excision weight measurement 0.0 0 97200 1858
PXO8-1/Cub blood total cholesterol level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood cholesterol amount male 127 days 10 62.0 mg/dl 1.3 4.11 enzymatic cholesterol assay 0.0 0 97224 1858
PXO6-3/Cub blood chylomicron cholesterol level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood chylomicron cholesterol amount male 127 days 10 0.02 mg/dl 0.0 0.01 enzymatic cholesterol assay 0.0 0 97345 1858
PXO10/Cub blood high density lipoprotein cholesterol level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood HDL cholesterol amount male 127 days 12 22.0 mg/dl 1.47 5.09 enzymatic cholesterol assay 0.0 0 97297 1858
PXO8-1/Cub blood high density lipoprotein cholesterol level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood HDL cholesterol amount male 127 days 10 45.97 mg/dl 1.02 3.23 enzymatic cholesterol assay 0.0 0 97310 1858
PXO6-2/Cub blood triglyceride level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood triglyceride amount male 127 days 8 40.6 mg/dl 3.9 11.03 enzymatic triglyceride assay 0.0 0 97323 1858
SHR-Ndufc2em1Mcwi+/+ urine total protein excretion rate controlled protein content diet (19.7 %) (for 28 days) and controlled potassium content diet (6.3 mg/g) (for 28 days) and controlled sodium content diet (3.7 mg/g) (for 28 days) Rubattu S, et al., J Am Heart Assoc. 2016 Feb 17;5(2). pii: e002701. doi: 10.1161/JAHA.115.002701. total urine protein amount not specified 70 days 10 27.0 mg/d 3.79 12.0 urine analysis 0.0 0 97933 1938
SHR-Ndufc2em1Mcwi-/+ urine total protein excretion rate controlled protein content diet (19.7 %) (for 28 days) and controlled potassium content diet (6.3 mg/g) (for 28 days) and controlled sodium content diet (3.7 mg/g) (for 28 days) Rubattu S, et al., J Am Heart Assoc. 2016 Feb 17;5(2). pii: e002701. doi: 10.1161/JAHA.115.002701. total urine protein amount not specified 70 days 17 24.0 mg/d 1.7 7.0 urine analysis 0.0 0 97936 1938
BXH2/Cub heart weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. heart mass male 127 days 18 3.7 g/kg 0.2 0.85 post excision weight measurement 0.0 0 97104 1858
PXO8-2/Cub blood low density lipoprotein cholesterol level controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. blood LDL cholesterol amount male 127 days 13 11.95 mg/dl 0.24 0.87 enzymatic cholesterol assay 0.0 0 change to mg/dl when available 97285 1858
PXO4/Cub both adrenal glands weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. adrenal gland mass male 127 days 9 13.0 mg/100g 0.8 2.4 post excision weight measurement 0.0 0 97392 1858
PXO1/Cub both adrenal glands weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. adrenal gland mass male 127 days 11 14.0 mg/100g 0.8 2.65 post excision weight measurement 0.0 0 97395 1858
SHR.BN-(D8Mit5-D8Mgh6)/Ipcv epididymal fat pad weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. epididymal fat pad mass male 127 days 13 0.89 % 0.03 0.11 post excision weight measurement 0.0 0 97518 1858
PXO6-1/Cub epididymal fat pad weight to body weight ratio controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. epididymal fat pad mass male 127 days 10 0.9 % 0.03 0.09 post excision weight measurement 0.0 0 97521 1858