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Study IDStudyExperiment NameExperiment NotesStrain Ont IDStrainSexAge# of AnimalsSample NotesClinical Measurement Ont IDPhenotypeFormulaClinical Measurement NotesAverage TypeValueUnitsSEMSDMethod Ont IDMethodMethod SiteMethod DurationMethod NotesPost Insult TypePost Insult Time ValuePost Insult Time UnitConditionsRecord IDCondition 1Condition 2Condition 3
2238Lankhorst S, et al., Hypertension. 2017 May;69(5):919-926. doi: 10.1161/HYPERTENSIONAHA.116.08565. Epub 2017 Mar 20.blood creatinine amountRS:0000916WKY/NHsdmale0 days8CMO:0000537plasma creatinine level0.31787282mg/dl0.01130.032MMO:0000306plasma creatinine analysis0.0controlled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then sunitinib (7 mg/kg/d) (for 8 days)99174controlled sodium content diet (8 %) (for 8 days)0.9% sodium chloride solution (0.9 %) (for 8 days)sunitinib (7 mg/kg/d) (for 8 days)
2238Lankhorst S, et al., Hypertension. 2017 May;69(5):919-926. doi: 10.1161/HYPERTENSIONAHA.116.08565. Epub 2017 Mar 20.blood creatinine amountRS:0000916WKY/NHsdmale0 days7CMO:0000537plasma creatinine level0.30090452mg/dl0.00790.021MMO:0000306plasma creatinine analysis0.0controlled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then vehicle control condition (0.5 ml) (for 8 days)99173controlled sodium content diet (8 %) (for 8 days)0.9% sodium chloride solution (0.9 %) (for 8 days)vehicle control condition (0.5 ml) (for 8 days)
2238Lankhorst S, et al., Hypertension. 2017 May;69(5):919-926. doi: 10.1161/HYPERTENSIONAHA.116.08565. Epub 2017 Mar 20.arterial blood pressure traitRS:0000916WKY/NHsdmale0 days8CMO:0000009mean arterial blood pressure124mmHg4.011.3137MMO:0000577intra-aortic radiotelemetry0.0controlled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then sunitinib (7 mg/kg/d) (for 8 days)99190controlled sodium content diet (8 %) (for 8 days)0.9% sodium chloride solution (0.9 %) (for 8 days)sunitinib (7 mg/kg/d) (for 8 days)
2238Lankhorst S, et al., Hypertension. 2017 May;69(5):919-926. doi: 10.1161/HYPERTENSIONAHA.116.08565. Epub 2017 Mar 20.arterial blood pressure traitRS:0000916WKY/NHsdmale0 days7CMO:0000009mean arterial blood pressure116mmHg1.02.6458MMO:0000577intra-aortic radiotelemetry0.0controlled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then vehicle control condition (0.5 ml) (for 8 days)99189controlled sodium content diet (8 %) (for 8 days)0.9% sodium chloride solution (0.9 %) (for 8 days)vehicle control condition (0.5 ml) (for 8 days)
2238Lankhorst S, et al., Hypertension. 2017 May;69(5):919-926. doi: 10.1161/HYPERTENSIONAHA.116.08565. Epub 2017 Mar 20.blood chloride amountRS:0000916WKY/NHsdmale0 days7CMO:0000059plasma chloride level104.8mmol/l1.84.7624MMO:0000037automated blood electrolyte analysis0.0controlled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then vehicle control condition (0.5 ml) (for 8 days)99169controlled sodium content diet (8 %) (for 8 days)0.9% sodium chloride solution (0.9 %) (for 8 days)vehicle control condition (0.5 ml) (for 8 days)
2238Lankhorst S, et al., Hypertension. 2017 May;69(5):919-926. doi: 10.1161/HYPERTENSIONAHA.116.08565. Epub 2017 Mar 20.blood chloride amountRS:0000916WKY/NHsdmale0 days8CMO:0000059plasma chloride level109.1mmol/l1.02.8284MMO:0000037automated blood electrolyte analysis0.0controlled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then sunitinib (7 mg/kg/d) (for 8 days)99170controlled sodium content diet (8 %) (for 8 days)0.9% sodium chloride solution (0.9 %) (for 8 days)sunitinib (7 mg/kg/d) (for 8 days)
2238Lankhorst S, et al., Hypertension. 2017 May;69(5):919-926. doi: 10.1161/HYPERTENSIONAHA.116.08565. Epub 2017 Mar 20.blood sodium amountRS:0000916WKY/NHsdmale0 days8CMO:0000060plasma sodium level139.4mmol/l1.74.8083MMO:0000037automated blood electrolyte analysis0.0controlled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then sunitinib (7 mg/kg/d) (for 8 days)99162controlled sodium content diet (8 %) (for 8 days)0.9% sodium chloride solution (0.9 %) (for 8 days)sunitinib (7 mg/kg/d) (for 8 days)
2238Lankhorst S, et al., Hypertension. 2017 May;69(5):919-926. doi: 10.1161/HYPERTENSIONAHA.116.08565. Epub 2017 Mar 20.blood sodium amountRS:0000916WKY/NHsdmale0 days7CMO:0000060plasma sodium level141.4mmol/l2.15.5561MMO:0000037automated blood electrolyte analysis0.0controlled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then vehicle control condition (0.5 ml) (for 8 days)99161controlled sodium content diet (8 %) (for 8 days)0.9% sodium chloride solution (0.9 %) (for 8 days)vehicle control condition (0.5 ml) (for 8 days)
2238Lankhorst S, et al., Hypertension. 2017 May;69(5):919-926. doi: 10.1161/HYPERTENSIONAHA.116.08565. Epub 2017 Mar 20.glomerular filtration traitRS:0000916WKY/NHsdmale0 days8CMO:0000765creatinine clearance3.5ml/min0.20.5657MMO:0000275urine creatinine analysis0.0controlled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then sunitinib (7 mg/kg/d) (for 8 days)99182controlled sodium content diet (8 %) (for 8 days)0.9% sodium chloride solution (0.9 %) (for 8 days)sunitinib (7 mg/kg/d) (for 8 days)
2238Lankhorst S, et al., Hypertension. 2017 May;69(5):919-926. doi: 10.1161/HYPERTENSIONAHA.116.08565. Epub 2017 Mar 20.glomerular filtration traitRS:0000916WKY/NHsdmale0 days7CMO:0000765creatinine clearance3.5ml/min0.30.7937MMO:0000275urine creatinine analysis0.0controlled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then vehicle control condition (0.5 ml) (for 8 days)99181controlled sodium content diet (8 %) (for 8 days)0.9% sodium chloride solution (0.9 %) (for 8 days)vehicle control condition (0.5 ml) (for 8 days)
2238Lankhorst S, et al., Hypertension. 2017 May;69(5):919-926. doi: 10.1161/HYPERTENSIONAHA.116.08565. Epub 2017 Mar 20.blood potassium amountRS:0000916WKY/NHsdmale0 days8CMO:0000061plasma potassium level4.4mmol/l0.41.1314MMO:0000037automated blood electrolyte analysis0.0controlled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then sunitinib (7 mg/kg/d) (for 8 days)99166controlled sodium content diet (8 %) (for 8 days)0.9% sodium chloride solution (0.9 %) (for 8 days)sunitinib (7 mg/kg/d) (for 8 days)
2238Lankhorst S, et al., Hypertension. 2017 May;69(5):919-926. doi: 10.1161/HYPERTENSIONAHA.116.08565. Epub 2017 Mar 20.blood potassium amountRS:0000916WKY/NHsdmale0 days7CMO:0000061plasma potassium level4.2mmol/l0.30.7937MMO:0000037automated blood electrolyte analysis0.0controlled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then vehicle control condition (0.5 ml) (for 8 days)99165controlled sodium content diet (8 %) (for 8 days)0.9% sodium chloride solution (0.9 %) (for 8 days)vehicle control condition (0.5 ml) (for 8 days)
2238Lankhorst S, et al., Hypertension. 2017 May;69(5):919-926. doi: 10.1161/HYPERTENSIONAHA.116.08565. Epub 2017 Mar 20.skin potassium amountRS:0000916WKY/NHsdmale0 days8CMO:0002773skin potassium level to skin water level ratioskin k/h2o69mmol/l2.57.0711MMO:0000584ex vivo analysis of atomic composition following dry ashing0.0ashed skincontrolled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then sunitinib (7 mg/kg/d) (for 8 days)99158controlled sodium content diet (8 %) (for 8 days)0.9% sodium chloride solution (0.9 %) (for 8 days)sunitinib (7 mg/kg/d) (for 8 days)
2238Lankhorst S, et al., Hypertension. 2017 May;69(5):919-926. doi: 10.1161/HYPERTENSIONAHA.116.08565. Epub 2017 Mar 20.skin potassium amountRS:0000916WKY/NHsdmale0 days7CMO:0002773skin potassium level to skin water level ratioskin k/h2o71mmol/l3.07.9373MMO:0000584ex vivo analysis of atomic composition following dry ashing0.0ashed skincontrolled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then vehicle control condition (0.5 ml) (for 8 days)99157controlled sodium content diet (8 %) (for 8 days)0.9% sodium chloride solution (0.9 %) (for 8 days)vehicle control condition (0.5 ml) (for 8 days)
2238Lankhorst S, et al., Hypertension. 2017 May;69(5):919-926. doi: 10.1161/HYPERTENSIONAHA.116.08565. Epub 2017 Mar 20.skin mineral amountRS:0000916WKY/NHsdmale0 days8CMO:0002772skin potassium level plus skin sodium level to skin water level ratioskin na+k/h2o0.1710.0040.0113MMO:0000584ex vivo analysis of atomic composition following dry ashing0.0ashed skincontrolled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then sunitinib (7 mg/kg/d) (for 8 days)99146controlled sodium content diet (8 %) (for 8 days)0.9% sodium chloride solution (0.9 %) (for 8 days)sunitinib (7 mg/kg/d) (for 8 days)
2238Lankhorst S, et al., Hypertension. 2017 May;69(5):919-926. doi: 10.1161/HYPERTENSIONAHA.116.08565. Epub 2017 Mar 20.skin mineral amountRS:0000916WKY/NHsdmale0 days7CMO:0002772skin potassium level plus skin sodium level to skin water level ratioskin na+k/h2o0.1760.0080.0212MMO:0000584ex vivo analysis of atomic composition following dry ashing0.0ashed skincontrolled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then vehicle control condition (0.5 ml) (for 8 days)99145controlled sodium content diet (8 %) (for 8 days)0.9% sodium chloride solution (0.9 %) (for 8 days)vehicle control condition (0.5 ml) (for 8 days)
2238Lankhorst S, et al., Hypertension. 2017 May;69(5):919-926. doi: 10.1161/HYPERTENSIONAHA.116.08565. Epub 2017 Mar 20.blood cystatin C amountRS:0000916WKY/NHsdmale0 days8CMO:0002778plasma cystatin C level3.9mg/l0.30.8485MMO:0000352automated plasma protein analysis0.0controlled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then sunitinib (7 mg/kg/d) (for 8 days)99178controlled sodium content diet (8 %) (for 8 days)0.9% sodium chloride solution (0.9 %) (for 8 days)sunitinib (7 mg/kg/d) (for 8 days)
2238Lankhorst S, et al., Hypertension. 2017 May;69(5):919-926. doi: 10.1161/HYPERTENSIONAHA.116.08565. Epub 2017 Mar 20.blood cystatin C amountRS:0000916WKY/NHsdmale0 days7CMO:0002778plasma cystatin C level3.5mg/l0.20.5292MMO:0000352automated plasma protein analysis0.0controlled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then vehicle control condition (0.5 ml) (for 8 days)99177controlled sodium content diet (8 %) (for 8 days)0.9% sodium chloride solution (0.9 %) (for 8 days)vehicle control condition (0.5 ml) (for 8 days)
2238Lankhorst S, et al., Hypertension. 2017 May;69(5):919-926. doi: 10.1161/HYPERTENSIONAHA.116.08565. Epub 2017 Mar 20.urine sodium amountRS:0000916WKY/NHsdmale0 days8CMO:0000760urine sodium excretion rate34.3mEq/d1.85.0912MMO:0000434urine sodium analysis0.0controlled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then sunitinib (7 mg/kg/d) (for 8 days)99186controlled sodium content diet (8 %) (for 8 days)0.9% sodium chloride solution (0.9 %) (for 8 days)sunitinib (7 mg/kg/d) (for 8 days)
2238Lankhorst S, et al., Hypertension. 2017 May;69(5):919-926. doi: 10.1161/HYPERTENSIONAHA.116.08565. Epub 2017 Mar 20.urine sodium amountRS:0000916WKY/NHsdmale0 days7CMO:0000760urine sodium excretion rate41.9mEq/d5.213.7579MMO:0000434urine sodium analysis0.0controlled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then vehicle control condition (0.5 ml) (for 8 days)99185controlled sodium content diet (8 %) (for 8 days)0.9% sodium chloride solution (0.9 %) (for 8 days)vehicle control condition (0.5 ml) (for 8 days)
2238Lankhorst S, et al., Hypertension. 2017 May;69(5):919-926. doi: 10.1161/HYPERTENSIONAHA.116.08565. Epub 2017 Mar 20.skin water amountRS:0000916WKY/NHsdmale0 days8CMO:0002771skin water level to skin dry weight ratioskin h2o ml/g1.522ml/g0.0040.0113MMO:0000584ex vivo analysis of atomic composition following dry ashing0.0ashed skincontrolled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then sunitinib (7 mg/kg/d) (for 8 days)99142controlled sodium content diet (8 %) (for 8 days)0.9% sodium chloride solution (0.9 %) (for 8 days)sunitinib (7 mg/kg/d) (for 8 days)
2238Lankhorst S, et al., Hypertension. 2017 May;69(5):919-926. doi: 10.1161/HYPERTENSIONAHA.116.08565. Epub 2017 Mar 20.skin water amountRS:0000916WKY/NHsdmale0 days7CMO:0002771skin water level to skin dry weight ratioskin h2o ml/g1.432ml/g0.0320.0847MMO:0000584ex vivo analysis of atomic composition following dry ashing0.0ashed skincontrolled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then vehicle control condition (0.5 ml) (for 8 days)99141controlled sodium content diet (8 %) (for 8 days)0.9% sodium chloride solution (0.9 %) (for 8 days)vehicle control condition (0.5 ml) (for 8 days)
2238Lankhorst S, et al., Hypertension. 2017 May;69(5):919-926. doi: 10.1161/HYPERTENSIONAHA.116.08565. Epub 2017 Mar 20.skin sodium amountRS:0000916WKY/NHsdmale0 days8CMO:0002769skin sodium level to skin dry weight ratiommol/g0.164REQUEST NEW VALUE0.0090.0255MMO:0000584ex vivo analysis of atomic composition following dry ashing0.0ashed skincontrolled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then sunitinib (7 mg/kg/d) (for 8 days)99134controlled sodium content diet (8 %) (for 8 days)0.9% sodium chloride solution (0.9 %) (for 8 days)sunitinib (7 mg/kg/d) (for 8 days)
2238Lankhorst S, et al., Hypertension. 2017 May;69(5):919-926. doi: 10.1161/HYPERTENSIONAHA.116.08565. Epub 2017 Mar 20.skin sodium amountRS:0000916WKY/NHsdmale0 days7CMO:0002769skin sodium level to skin dry weight ratiommol/g0.144REQUEST NEW VALUE0.0050.0132MMO:0000584ex vivo analysis of atomic composition following dry ashing0.0ashed skincontrolled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then vehicle control condition (0.5 ml) (for 8 days)99133controlled sodium content diet (8 %) (for 8 days)0.9% sodium chloride solution (0.9 %) (for 8 days)vehicle control condition (0.5 ml) (for 8 days)
2238Lankhorst S, et al., Hypertension. 2017 May;69(5):919-926. doi: 10.1161/HYPERTENSIONAHA.116.08565. Epub 2017 Mar 20.skin chloride amountRS:0000916WKY/NHsdmale0 days8CMO:0002770skin chloride level to skin dry weight ratioskin cl mmol/g0.073mmol/g0.0070.0198MMO:0000584ex vivo analysis of atomic composition following dry ashing0.0ashed skincontrolled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then sunitinib (7 mg/kg/d) (for 8 days)99138controlled sodium content diet (8 %) (for 8 days)0.9% sodium chloride solution (0.9 %) (for 8 days)sunitinib (7 mg/kg/d) (for 8 days)
2238Lankhorst S, et al., Hypertension. 2017 May;69(5):919-926. doi: 10.1161/HYPERTENSIONAHA.116.08565. Epub 2017 Mar 20.skin chloride amountRS:0000916WKY/NHsdmale0 days7CMO:0002770skin chloride level to skin dry weight ratioskin cl mmol/g0.068mmol/g0.0060.0159MMO:0000584ex vivo analysis of atomic composition following dry ashing0.0ashed skincontrolled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then vehicle control condition (0.5 ml) (for 8 days)99137controlled sodium content diet (8 %) (for 8 days)0.9% sodium chloride solution (0.9 %) (for 8 days)vehicle control condition (0.5 ml) (for 8 days)
2238Lankhorst S, et al., Hypertension. 2017 May;69(5):919-926. doi: 10.1161/HYPERTENSIONAHA.116.08565. Epub 2017 Mar 20.skin chloride amountRS:0000916WKY/NHsdmale0 days8CMO:0002775skin chloride level to skin water level ratioskin cl/h2o50mmol/l4.412.4451MMO:0000584ex vivo analysis of atomic composition following dry ashing0.0ashed skincontrolled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then sunitinib (7 mg/kg/d) (for 8 days)99154controlled sodium content diet (8 %) (for 8 days)0.9% sodium chloride solution (0.9 %) (for 8 days)sunitinib (7 mg/kg/d) (for 8 days)
2238Lankhorst S, et al., Hypertension. 2017 May;69(5):919-926. doi: 10.1161/HYPERTENSIONAHA.116.08565. Epub 2017 Mar 20.skin chloride amountRS:0000916WKY/NHsdmale0 days7CMO:0002775skin chloride level to skin water level ratioskin cl/h2o48mmol/l4.812.6996MMO:0000584ex vivo analysis of atomic composition following dry ashing0.0ashed skincontrolled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then vehicle control condition (0.5 ml) (for 8 days)99153controlled sodium content diet (8 %) (for 8 days)0.9% sodium chloride solution (0.9 %) (for 8 days)vehicle control condition (0.5 ml) (for 8 days)
2238Lankhorst S, et al., Hypertension. 2017 May;69(5):919-926. doi: 10.1161/HYPERTENSIONAHA.116.08565. Epub 2017 Mar 20.skin chloride amountRS:0000916WKY/NHsdmale0 days8CMO:0002775skin chloride level to skin water level ratioskin na/h2o108mmol/l4.412.4451MMO:0000584ex vivo analysis of atomic composition following dry ashing0.0ashed skincontrolled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then sunitinib (7 mg/kg/d) (for 8 days)99150controlled sodium content diet (8 %) (for 8 days)0.9% sodium chloride solution (0.9 %) (for 8 days)sunitinib (7 mg/kg/d) (for 8 days)
2238Lankhorst S, et al., Hypertension. 2017 May;69(5):919-926. doi: 10.1161/HYPERTENSIONAHA.116.08565. Epub 2017 Mar 20.skin chloride amountRS:0000916WKY/NHsdmale0 days7CMO:0002775skin chloride level to skin water level ratioskin na/h2o101mmol/l3.910.3184MMO:0000584ex vivo analysis of atomic composition following dry ashing0.0ashed skincontrolled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then vehicle control condition (0.5 ml) (for 8 days)99149controlled sodium content diet (8 %) (for 8 days)0.9% sodium chloride solution (0.9 %) (for 8 days)vehicle control condition (0.5 ml) (for 8 days)

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