SS-Chr 6BN/Mcwi |
urine total protein excretion rate |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
total urine protein amount |
female |
80 days-99 days |
10 |
84.16 |
mg/d |
14.48 |
45.8 |
automated urine total protein analysis |
|
0 |
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52683 |
482 |
SS-Chr 6BN/Mcwi |
urine total protein excretion rate |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
total urine protein amount |
male |
80 days-99 days |
9 |
89.78 |
mg/d |
14.56 |
43.68 |
automated urine total protein analysis |
|
0 |
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52688 |
482 |
SS-Chr 6BN/Mcwi |
plasma renin activity level |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
renin activity |
male |
80 days-99 days |
8 |
1.2 |
ng/ml/h |
0.42 |
1.18 |
radioimmunoassay |
|
0 |
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52443 |
482 |
SS-Chr 6BN/Mcwi |
maximum contractile force per wet weight of aorta |
controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
female |
70 days-84 days |
21 |
1.51 |
g/mg |
0.13 |
0.6 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
57316 |
522 |
SS-Chr 6BN/Mcwi |
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70 days-84 days |
10 |
-8.37 |
null |
0.05 |
0.16 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
56025 |
522 |
SS-Chr 6BN/Mcwi |
logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
male |
70 days-84 days |
21 |
-7.68 |
null |
0.11 |
0.48 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
EC50 value is moles/liter |
Moms and pups used in studies were fed Teklad |
56094 |
522 |
SS-Chr 6BN/Mcwi |
hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70 days-84 days |
8 |
36.25 |
% |
5.54 |
15.66 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
56275 |
522 |
SS-Chr 6BN/Mcwi |
concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70 days-84 days |
15 |
2.77 |
E-7mole |
1.53 |
5.92 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
56502 |
522 |
SS-Chr 6BN/Mcwi |
concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70 days-84 days |
17 |
6.71 |
E-7mole |
2.23 |
9.19 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
56509 |
522 |
SS-Chr 6BN/Mcwi |
body weight |
controlled sodium content diet (4 %) (for 21 days) |
PhysGen Vascular data |
body mass |
male |
70 days-84 days |
21 |
294.3 |
g |
6.6 |
30.1 |
whole body digital scale |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
55172 |
522 |
SS-Chr 6BN/Mcwi |
urine sodium excretion rate |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
urine sodium amount |
male |
80 days-99 days |
9 |
9.79 |
mEq/d |
2.32 |
6.96 |
flame atomic emission spectrometry |
|
0 |
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52739 |
482 |
SS-Chr 6BN/Mcwi |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
female |
80 days-99 days |
7 |
1.3 |
ml/min |
0.1 |
0.28 |
urine creatinine analysis |
|
0 |
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52144 |
482 |
SS-Chr 6BN/Mcwi |
urine potassium excretion rate |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
urine potassium amount |
male |
80 days-99 days |
9 |
1.09 |
mEq/d |
0.17 |
0.5 |
flame atomic emission spectrometry |
|
0 |
urine potassium analysis |
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52935 |
482 |
SS-Chr 6BN/Mcwi |
urine albumin excretion rate |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
urine albumin amount |
female |
80 days-99 days |
10 |
11.6 |
mg/d |
4.48 |
14.16 |
radioimmunoassay |
|
0 |
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52583 |
482 |
SS-Chr 6BN/Mcwi |
hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70 days-84 days |
4 |
52.25 |
% |
9.99 |
19.97 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
57138 |
522 |
SS-Chr 6BN/Mcwi |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
male |
80 days-99 days |
8 |
1.87 |
ml/min |
0.24 |
0.68 |
urine creatinine analysis |
|
0 |
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52149 |
482 |
SS-Chr 6BN/Mcwi |
heart rate |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
heart pumping trait |
male |
80 days-99 days |
10 |
427.88 |
beats/min |
12.27 |
38.8 |
vascular fluid filled catheter |
|
0 |
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52639 |
482 |
SS-Chr 6BN/Mcwi |
hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70 days-84 days |
8 |
26.5 |
% |
5.46 |
15.46 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
56280 |
522 |
SS-Chr 6BN/Mcwi |
sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70 days-84 days |
10 |
100.0 |
% |
0.0 |
0.0 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
56312 |
522 |
SS-Chr 6BN/Mcwi |
acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70 days-84 days |
17 |
52.06 |
% |
5.41 |
22.3 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
54769 |
522 |
SS-Chr 6BN/Mcwi |
body weight |
controlled sodium content diet (4 %) (for 21 days) |
PhysGen Vascular data |
body mass |
female |
70 days-84 days |
21 |
198.6 |
g |
2.6 |
11.8 |
whole body digital scale |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
55167 |
522 |
SS-Chr 6BN/Mcwi |
logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70 days-84 days |
17 |
-6.61 |
null |
0.13 |
0.54 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
56904 |
522 |
SS-Chr 6BN/Mcwi |
hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70 days-84 days |
3 |
40.0 |
% |
6.93 |
12.0 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
57143 |
522 |
SS-Chr 6BN/Mcwi |
sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70 days-84 days |
9 |
100.0 |
% |
0.0 |
0.0 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
56307 |
522 |
SS-Chr 6BN/Mcwi |
plasma creatinine level |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
blood creatinine amount |
male |
80 days-99 days |
8 |
0.32 |
mg/dl |
0.02 |
0.06 |
radioimmunoassay |
|
0 |
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52198 |
482 |
SS-Chr 6BN/Mcwi |
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70 days-84 days |
9 |
-8.78 |
null |
0.16 |
0.48 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
56020 |
522 |
SS-Chr 6BN/Mcwi |
concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70 days-84 days |
9 |
0.03 |
10E-7mol/l |
0.0 |
0.01 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
56232 |
522 |
SS-Chr 6BN/Mcwi |
concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70 days-84 days |
10 |
0.05 |
10E-7mol/l |
0.01 |
0.02 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
56237 |
522 |
SS-Chr 6BN/Mcwi |
concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
male |
70 days-84 days |
21 |
0.04 |
umol/l |
0.01 |
0.05 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
54895 |
522 |
SS-Chr 6BN/Mcwi |
urine sodium excretion rate |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
urine sodium amount |
female |
80 days-99 days |
10 |
11.08 |
mEq/d |
1.72 |
5.43 |
flame atomic emission spectrometry |
|
0 |
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52734 |
482 |
SS-Chr 6BN/Mcwi |
hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70 days-84 days |
8 |
24.25 |
% |
4.97 |
14.05 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
55080 |
522 |
SS-Chr 6BN/Mcwi |
maximum contractile force per wet weight of aorta |
controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
male |
70 days-84 days |
21 |
0.97 |
g/mg |
0.09 |
0.42 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
57323 |
522 |
SS-Chr 6BN/Mcwi |
mean arterial blood pressure |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
arterial blood pressure trait |
female |
80 days-99 days |
9 |
160.76 |
mmHg |
6.88 |
20.63 |
vascular fluid filled catheter |
|
0 |
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52832 |
482 |
SS-Chr 6BN/Mcwi |
mean arterial blood pressure |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
arterial blood pressure trait |
male |
80 days-99 days |
10 |
176.2 |
mmHg |
5.38 |
17.0 |
vascular fluid filled catheter |
|
0 |
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52837 |
482 |
SS-Chr 6BN/Mcwi |
logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
female |
70 days-84 days |
20 |
-7.78 |
null |
0.1 |
0.45 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
EC50 value is moles/liter |
Moms and pups used in studies were fed Teklad |
56087 |
522 |
SS-Chr 6BN/Mcwi |
hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70 days-84 days |
8 |
28.25 |
% |
5.29 |
14.95 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
55075 |
522 |
SS-Chr 6BN/Mcwi |
logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70 days-84 days |
15 |
-6.98 |
null |
0.14 |
0.56 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
56897 |
522 |
SS-Chr 6BN/Mcwi |
concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
female |
70 days-84 days |
20 |
0.03 |
umol/l |
0.01 |
0.03 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
54888 |
522 |
SS-Chr 6BN/Mcwi |
plasma creatinine level |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
blood creatinine amount |
female |
80 days-99 days |
7 |
0.38 |
mg/dl |
0.03 |
0.09 |
radioimmunoassay |
|
0 |
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52193 |
482 |
SS-Chr 6BN/Mcwi |
urine albumin excretion rate |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
urine albumin amount |
male |
80 days-99 days |
9 |
26.28 |
mg/d |
5.67 |
17.01 |
radioimmunoassay |
|
0 |
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52588 |
482 |
SS-Chr 6BN/Mcwi |
heart rate |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
heart pumping trait |
female |
80 days-99 days |
9 |
421.12 |
beats/min |
11.29 |
33.88 |
vascular fluid filled catheter |
|
0 |
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52634 |
482 |
SS-Chr 6BN/Mcwi |
acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70 days-84 days |
15 |
55.73 |
% |
5.7 |
22.09 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
54762 |
522 |
SS-Chr 6BN/Mcwi |
urine potassium excretion rate |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
urine potassium amount |
female |
80 days-99 days |
10 |
0.9 |
mEq/d |
0.06 |
0.2 |
flame atomic emission spectrometry |
|
0 |
urine potassium analysis |
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52930 |
482 |
SS-Chr 6BN/Mcwi |
plasma renin activity level |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
renin activity |
female |
80 days-99 days |
6 |
3.55 |
ng/ml/h |
1.2 |
2.94 |
radioimmunoassay |
|
0 |
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52438 |
482 |