Phenominer Database Results (44 results)

 

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Strain Phenotype Conditions Study Experiment Name Sex Age # of Animals Value Units SEM SD Method Method Duration Post Insult Time Value Method Notes Clinical Measurement Notes Experiment Notes Record ID Study ID
SS-Chr 2BN/Mcwi maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 16 1.34 g/mg 0.11 0.44 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57391 522
SS-Chr 2BN/Mcwi logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 10 -8.41 null 0.2 0.62 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56043 522
SS-Chr 2BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 10 0.04 umol/l 0.01 0.03 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54971 522
SS-Chr 2BN/Mcwi concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 10 0.17 10E-7mol/l 0.14 0.43 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56255 522
SS-Chr 2BN/Mcwi creatinine clearance controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data glomerular filtration trait male 80 days-99 days 9 2.27 ml/min 0.15 0.46 urine creatinine analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52189 482
SS-Chr 2BN/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 15 36.0 % 4.72 18.29 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55093 522
SS-Chr 2BN/Mcwi urine potassium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine potassium amount male 80 days-99 days 10 1.47 mEq/d 0.18 0.58 flame atomic emission spectrometry 0 urine potassium analysis Moms were fed Teklad, pups used in studies were fed Dyets 52975 482
SS-Chr 2BN/Mcwi heart rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data heart pumping trait female 80 days-99 days 10 400.36 beats/min 6.22 19.67 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52673 482
SS-Chr 2BN/Mcwi body weight controlled sodium content diet (4 %) (for 21 days) PhysGen Vascular data body mass male 70 days-84 days 10 277.2 g 3.2 10.0 whole body digital scale 0 Moms and pups used in studies were fed Teklad 55244 522
SS-Chr 2BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 16 -7.24 null 0.04 0.15 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 56162 522
SS-Chr 2BN/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 10 16.4 % 0.97 3.06 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55098 522
SS-Chr 2BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 14 0.92 E-7mole 0.33 1.25 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56577 522
SS-Chr 2BN/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 10 55.2 % 1.96 6.2 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57161 522
SS-Chr 2BN/Mcwi urine total protein excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data total urine protein amount male 80 days-99 days 10 174.3 mg/d 23.06 72.93 automated urine total protein analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52728 482
SS-Chr 2BN/Mcwi mean arterial blood pressure controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data arterial blood pressure trait female 80 days-99 days 10 150.38 mmHg 3.4 10.75 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52871 482
SS-Chr 2BN/Mcwi mean arterial blood pressure controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data arterial blood pressure trait male 80 days-99 days 9 174.74 mmHg 5.35 16.04 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52877 482
SS-Chr 2BN/Mcwi heart rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data heart pumping trait male 80 days-99 days 9 397.25 beats/min 8.94 26.81 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52679 482
SS-Chr 2BN/Mcwi urine total protein excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data total urine protein amount female 80 days-99 days 10 65.93 mg/d 11.1 35.11 automated urine total protein analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52722 482
SS-Chr 2BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data renin activity female 80 days-99 days 10 0.99 ng/ml/h 0.13 0.43 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52477 482
SS-Chr 2BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine albumin amount male 80 days-99 days 10 73.9 mg/d 13.02 41.18 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52628 482
SS-Chr 2BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 16 0.06 umol/l 0.01 0.02 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54963 522
SS-Chr 2BN/Mcwi sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 14 98.21 % 0.74 2.78 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56325 522
SS-Chr 2BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount female 80 days-99 days 10 0.32 mg/dl 0.02 0.06 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52232 482
SS-Chr 2BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount male 80 days-99 days 9 0.35 mg/dl 0.02 0.05 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52238 482
SS-Chr 2BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine albumin amount female 80 days-99 days 10 13.96 mg/d 1.96 6.2 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52622 482
SS-Chr 2BN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 14 -7.21 null 0.1 0.38 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56972 522
SS-Chr 2BN/Mcwi urine sodium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine sodium amount female 80 days-99 days 10 12.32 mEq/d 1.69 5.33 flame atomic emission spectrometry 0 Moms were fed Teklad, pups used in studies were fed Dyets 52773 482
SS-Chr 2BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data renin activity male 80 days-99 days 9 0.58 ng/ml/h 0.1 0.29 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52483 482
SS-Chr 2BN/Mcwi urine potassium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine potassium amount female 80 days-99 days 10 0.91 mEq/d 0.08 0.25 flame atomic emission spectrometry 0 urine potassium analysis Moms were fed Teklad, pups used in studies were fed Dyets 52969 482
SS-Chr 2BN/Mcwi sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 10 90.7 % 3.32 10.5 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56330 522
SS-Chr 2BN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 9 42.56 % 4.54 13.63 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54845 522
SS-Chr 2BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 10 -7.52 null 0.1 0.32 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 56170 522
SS-Chr 2BN/Mcwi concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 14 0.03 10E-7mol/l 0.01 0.03 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56250 522
SS-Chr 2BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 9 0.56 E-7mole 0.09 0.28 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56585 522
SS-Chr 2BN/Mcwi creatinine clearance controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data glomerular filtration trait female 80 days-99 days 10 1.53 ml/min 0.14 0.44 urine creatinine analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52183 482
SS-Chr 2BN/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 15 53.47 % 3.3 12.79 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57156 522
SS-Chr 2BN/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 15 34.6 % 4.62 17.89 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56293 522
SS-Chr 2BN/Mcwi urine sodium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine sodium amount male 80 days-99 days 10 18.08 mEq/d 2.1 6.64 flame atomic emission spectrometry 0 Moms were fed Teklad, pups used in studies were fed Dyets 52779 482
SS-Chr 2BN/Mcwi maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 10 1.05 g/mg 0.15 0.48 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57399 522
SS-Chr 2BN/Mcwi body weight controlled sodium content diet (4 %) (for 21 days) PhysGen Vascular data body mass female 70 days-84 days 16 193.0 g 2.5 9.9 whole body digital scale 0 Moms and pups used in studies were fed Teklad 55236 522
SS-Chr 2BN/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 10 18.2 % 1.59 5.03 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56298 522
SS-Chr 2BN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 14 63.07 % 5.21 19.51 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54837 522
SS-Chr 2BN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 9 -7.3 null 0.07 0.22 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56980 522
SS-Chr 2BN/Mcwi logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 14 -8.76 null 0.1 0.36 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56038 522