FHH-Chr 7BN/Mcwi |
plasma renin activity level |
controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) |
PhysGen Renal B data |
renin activity |
male |
80 days-99 days |
8 |
1.15 |
ng/ml/h |
0.48 |
1.35 |
radioimmunoassay |
|
0 |
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52922 |
482 |
FHH-Chr 7BN/Mcwi |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
female |
80 days-99 days |
7 |
1.44 |
ml/min |
0.23 |
0.6 |
urine creatinine analysis |
|
0 |
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52377 |
482 |
FHH-Chr 7BN/Mcwi |
logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
female |
70 days-84 days |
9 |
-8.26 |
null |
0.07 |
0.21 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
EC50 value is moles/liter |
Moms and pups used in studies were fed Teklad |
56160 |
522 |
FHH-Chr 7BN/Mcwi |
logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70 days-84 days |
10 |
-6.96 |
null |
0.07 |
0.22 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
56970 |
522 |
FHH-Chr 7BN/Mcwi |
plasma creatinine level |
controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) |
PhysGen Renal B data |
blood creatinine amount |
male |
80 days-99 days |
8 |
0.51 |
mg/dl |
0.05 |
0.14 |
radioimmunoassay |
|
0 |
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52287 |
482 |
FHH-Chr 7BN/Mcwi |
body weight |
controlled sodium content diet (4 %) (for 21 days) |
PhysGen Vascular data |
body mass |
female |
70 days-84 days |
10 |
195.3 |
g |
7.2 |
22.7 |
whole body digital scale |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
55234 |
522 |
FHH-Chr 7BN/Mcwi |
concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70 days-84 days |
10 |
1.21 |
E-7mole |
0.18 |
0.57 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
56575 |
522 |
FHH-Chr 7BN/Mcwi |
concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70 days-84 days |
9 |
1.05 |
E-7mole |
0.12 |
0.36 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
56583 |
522 |
FHH-Chr 7BN/Mcwi |
urine albumin excretion rate |
controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) |
PhysGen Renal B data |
urine albumin amount |
female |
80 days-99 days |
9 |
64.2 |
mg/d |
29.52 |
88.56 |
radioimmunoassay |
|
0 |
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52424 |
482 |
FHH-Chr 7BN/Mcwi |
urine total protein excretion rate |
controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) |
PhysGen Renal B data |
total urine protein amount |
male |
80 days-99 days |
13 |
379.56 |
mg/d |
75.35 |
271.67 |
automated urine total protein analysis |
|
0 |
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52138 |
482 |
FHH-Chr 7BN/Mcwi |
urine sodium excretion rate |
controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) |
PhysGen Renal B data |
urine sodium amount |
male |
80 days-99 days |
11 |
14.23 |
mEq/d |
3.75 |
12.43 |
flame atomic emission spectrometry |
|
0 |
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52824 |
482 |
FHH-Chr 7BN/Mcwi |
plasma creatinine level |
controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) |
PhysGen Renal B data |
blood creatinine amount |
female |
80 days-99 days |
7 |
0.34 |
mg/dl |
0.01 |
0.02 |
radioimmunoassay |
|
0 |
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52281 |
482 |
FHH-Chr 7BN/Mcwi |
acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70 days-84 days |
9 |
82.44 |
% |
6.48 |
19.45 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
54843 |
522 |
FHH-Chr 7BN/Mcwi |
concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
male |
70 days-84 days |
8 |
0.01 |
umol/l |
0.0 |
0.01 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
54969 |
522 |
FHH-Chr 7BN/Mcwi |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
male |
80 days-99 days |
8 |
1.24 |
ml/min |
0.29 |
0.81 |
urine creatinine analysis |
|
0 |
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52383 |
482 |
FHH-Chr 7BN/Mcwi |
maximum contractile force per wet weight of aorta |
controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
male |
70 days-84 days |
9 |
1.2 |
g/mg |
0.1 |
0.29 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
57397 |
522 |
FHH-Chr 7BN/Mcwi |
plasma renin activity level |
controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) |
PhysGen Renal B data |
renin activity |
female |
80 days-99 days |
7 |
1.89 |
ng/ml/h |
0.44 |
1.17 |
radioimmunoassay |
|
0 |
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52916 |
482 |
FHH-Chr 7BN/Mcwi |
heart rate |
controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) |
PhysGen Renal B data |
heart pumping trait |
female |
80 days-99 days |
9 |
427.55 |
beats/min |
5.81 |
17.42 |
vascular fluid filled catheter |
|
0 |
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52522 |
482 |
FHH-Chr 7BN/Mcwi |
mean arterial blood pressure |
controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) |
PhysGen Renal B data |
arterial blood pressure trait |
female |
80 days-99 days |
9 |
148.65 |
mmHg |
7.47 |
22.42 |
vascular fluid filled catheter |
|
0 |
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52569 |
482 |
FHH-Chr 7BN/Mcwi |
urine potassium excretion rate |
controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) |
PhysGen Renal B data |
urine potassium amount |
male |
80 days-99 days |
11 |
1.54 |
mEq/d |
0.41 |
1.36 |
flame atomic emission spectrometry |
|
0 |
urine potassium analysis |
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52336 |
482 |
FHH-Chr 7BN/Mcwi |
acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70 days-84 days |
10 |
70.6 |
% |
5.09 |
16.11 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
54835 |
522 |
FHH-Chr 7BN/Mcwi |
concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
female |
70 days-84 days |
9 |
0.01 |
umol/l |
0.0 |
0.0 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
54961 |
522 |
FHH-Chr 7BN/Mcwi |
maximum contractile force per wet weight of aorta |
controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
female |
70 days-84 days |
10 |
1.33 |
g/mg |
0.18 |
0.56 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
57389 |
522 |
FHH-Chr 7BN/Mcwi |
urine total protein excretion rate |
controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) |
PhysGen Renal B data |
total urine protein amount |
female |
80 days-99 days |
9 |
157.32 |
mg/d |
66.79 |
200.37 |
automated urine total protein analysis |
|
0 |
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52132 |
482 |
FHH-Chr 7BN/Mcwi |
urine sodium excretion rate |
controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) |
PhysGen Renal B data |
urine sodium amount |
female |
80 days-99 days |
9 |
14.46 |
mEq/d |
2.21 |
6.62 |
flame atomic emission spectrometry |
|
0 |
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52818 |
482 |
FHH-Chr 7BN/Mcwi |
urine potassium excretion rate |
controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) |
PhysGen Renal B data |
urine potassium amount |
female |
80 days-99 days |
9 |
1.08 |
mEq/d |
0.2 |
0.61 |
flame atomic emission spectrometry |
|
0 |
urine potassium analysis |
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52330 |
482 |
FHH-Chr 7BN/Mcwi |
body weight |
controlled sodium content diet (4 %) (for 21 days) |
PhysGen Vascular data |
body mass |
male |
70 days-84 days |
9 |
252.3 |
g |
5.3 |
16.0 |
whole body digital scale |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
55242 |
522 |
FHH-Chr 7BN/Mcwi |
logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
male |
70 days-84 days |
8 |
-8.16 |
null |
0.1 |
0.28 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
EC50 value is moles/liter |
Moms and pups used in studies were fed Teklad |
56168 |
522 |
FHH-Chr 7BN/Mcwi |
logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70 days-84 days |
9 |
-7.0 |
null |
0.06 |
0.17 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
56978 |
522 |
FHH-Chr 7BN/Mcwi |
urine albumin excretion rate |
controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) |
PhysGen Renal B data |
urine albumin amount |
male |
80 days-99 days |
13 |
152.95 |
mg/d |
36.62 |
132.03 |
radioimmunoassay |
|
0 |
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52430 |
482 |
FHH-Chr 7BN/Mcwi |
heart rate |
controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) |
PhysGen Renal B data |
heart pumping trait |
male |
80 days-99 days |
9 |
429.18 |
beats/min |
10.25 |
30.75 |
vascular fluid filled catheter |
|
0 |
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52528 |
482 |
FHH-Chr 7BN/Mcwi |
mean arterial blood pressure |
controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) |
PhysGen Renal B data |
arterial blood pressure trait |
male |
80 days-99 days |
9 |
185.36 |
mmHg |
6.33 |
18.99 |
vascular fluid filled catheter |
|
0 |
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52575 |
482 |