8 | plasma creatinine level | WKY/NHsd | male | 0.35180942 | mg/dl | standard rat chow (for 8 days) then sunitinib (7 mg/kg/d) (for 8 days) | 99172 | standard rat chow (for 8 days) | | | sunitinib (7 mg/kg/d) (for 8 days) |

7 | plasma creatinine level | WKY/NHsd | male | 0.30882306 | mg/dl | standard rat chow (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) | 99171 | standard rat chow (for 8 days) | | | vehicle control condition (0.5 ml) (for 8 days) |

14 | mean arterial blood pressure | LN/MavRrrcAek | male | 99.9 | mmHg | standard rat chow (for 98 days) then controlled sodium content diet (4 %) (for 21 days) | 102608 | standard rat chow (for 98 days) | | | controlled sodium content diet (4 %) (for 21 days) |

9 | mean arterial blood pressure | LH/MavRrrcAek | male | 136.1 | mmHg | standard rat chow (for 98 days) then controlled sodium content diet (4 %) (for 21 days) | 102607 | standard rat chow (for 98 days) | | | controlled sodium content diet (4 %) (for 21 days) |

14 | mean arterial blood pressure | LN/MavRrrcAek | male | 98.4 | mmHg | standard rat chow (for 98 days) | 102602 | standard rat chow (for 98 days) | | | |

9 | mean arterial blood pressure | LH/MavRrrcAek | male | 122 | mmHg | standard rat chow (for 98 days) | 102601 | standard rat chow (for 98 days) | | | |

8 | mean arterial blood pressure | WKY/NHsd | male | 128 | mmHg | standard rat chow (for 8 days) then sunitinib (7 mg/kg/d) (for 8 days) | 99188 | standard rat chow (for 8 days) | | | sunitinib (7 mg/kg/d) (for 8 days) |

7 | mean arterial blood pressure | WKY/NHsd | male | 101 | mmHg | standard rat chow (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) | 99187 | standard rat chow (for 8 days) | | | vehicle control condition (0.5 ml) (for 8 days) |

8 | plasma chloride level | WKY/NHsd | male | 100.5 | mmol/l | standard rat chow (for 8 days) then sunitinib (7 mg/kg/d) (for 8 days) | 99168 | standard rat chow (for 8 days) | | | sunitinib (7 mg/kg/d) (for 8 days) |

7 | plasma chloride level | WKY/NHsd | male | 98.2 | mmol/l | standard rat chow (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) | 99167 | standard rat chow (for 8 days) | | | vehicle control condition (0.5 ml) (for 8 days) |

14 | systolic blood pressure | LN/MavRrrcAek | male | 116 | mmHg | standard rat chow (for 98 days) then controlled sodium content diet (4 %) (for 21 days) | 102610 | standard rat chow (for 98 days) | | | controlled sodium content diet (4 %) (for 21 days) |

9 | systolic blood pressure | LH/MavRrrcAek | male | 161.2 | mmHg | standard rat chow (for 98 days) then controlled sodium content diet (4 %) (for 21 days) | 102609 | standard rat chow (for 98 days) | | | controlled sodium content diet (4 %) (for 21 days) |

14 | systolic blood pressure | LN/MavRrrcAek | male | 114.5 | mmHg | standard rat chow (for 98 days) | 102604 | standard rat chow (for 98 days) | | | |

9 | systolic blood pressure | LH/MavRrrcAek | male | 147.5 | mmHg | standard rat chow (for 98 days) | 102603 | standard rat chow (for 98 days) | | | |

14 | abdominal fat pad weight | LN/MavRrrcAek | male | 0.72 | g | standard rat chow (for 98 days) then controlled sodium content diet (4 %) (for 21 days) | 102620 | standard rat chow (for 98 days) | | | controlled sodium content diet (4 %) (for 21 days) |

9 | abdominal fat pad weight | LH/MavRrrcAek | male | 1.43 | g | standard rat chow (for 98 days) then controlled sodium content diet (4 %) (for 21 days) | 102619 | standard rat chow (for 98 days) | | | controlled sodium content diet (4 %) (for 21 days) |

8 | both kidneys wet weight to body weight ratio | SBH/Ygl | male | 2.6 | g/kg | sham surgical control condition (for 56 days) and water (for 56 days) and standard rat chow (for 56 days) | 106649 | sham surgical control condition (for 56 days) | water (for 56 days) | standard rat chow (for 56 days) | |

8 | both kidneys wet weight to body weight ratio | SBN/Ygl | male | 2.4 | g/kg | sham surgical control condition (for 56 days) and water (for 56 days) and standard rat chow (for 56 days) | 106646 | sham surgical control condition (for 56 days) | water (for 56 days) | standard rat chow (for 56 days) | |

14 | diastolic blood pressure | LN/MavRrrcAek | male | 86.1 | mmHg | standard rat chow (for 98 days) then controlled sodium content diet (4 %) (for 21 days) | 102612 | standard rat chow (for 98 days) | | | controlled sodium content diet (4 %) (for 21 days) |

9 | diastolic blood pressure | LH/MavRrrcAek | male | 113.9 | mmHg | standard rat chow (for 98 days) then controlled sodium content diet (4 %) (for 21 days) | 102611 | standard rat chow (for 98 days) | | | controlled sodium content diet (4 %) (for 21 days) |

14 | diastolic blood pressure | LN/MavRrrcAek | male | 84.9 | mmHg | standard rat chow (for 98 days) | 102606 | standard rat chow (for 98 days) | | | |

9 | diastolic blood pressure | LH/MavRrrcAek | male | 100.8 | mmHg | standard rat chow (for 98 days) | 102605 | standard rat chow (for 98 days) | | | |

14 | plasma glucose level | LN/MavRrrcAek | male | 155.5 | mg/dl | standard rat chow (for 98 days) then controlled sodium content diet (4 %) (for 14 days) | 102624 | standard rat chow (for 98 days) | | | controlled sodium content diet (4 %) (for 14 days) |

9 | plasma glucose level | LH/MavRrrcAek | male | 141.9 | mg/dl | standard rat chow (for 98 days) then controlled sodium content diet (4 %) (for 14 days) | 102623 | standard rat chow (for 98 days) | | | controlled sodium content diet (4 %) (for 14 days) |

14 | plasma glucose level | LN/MavRrrcAek | male | 149.8 | mg/dl | standard rat chow (for 84 days) | 102622 | standard rat chow (for 84 days) | | | |

9 | plasma glucose level | LH/MavRrrcAek | male | 116.5 | mg/dl | standard rat chow (for 84 days) | 102621 | standard rat chow (for 84 days) | | | |

8 | plasma sodium level | WKY/NHsd | male | 137.8 | mmol/l | standard rat chow (for 8 days) then sunitinib (7 mg/kg/d) (for 8 days) | 99160 | standard rat chow (for 8 days) | | | sunitinib (7 mg/kg/d) (for 8 days) |

7 | plasma sodium level | WKY/NHsd | male | 143.7 | mmol/l | standard rat chow (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) | 99159 | standard rat chow (for 8 days) | | | vehicle control condition (0.5 ml) (for 8 days) |

14 | heart rate | LN/MavRrrcAek | male | 346.5 | beats/min | standard rat chow (for 98 days) then controlled sodium content diet (4 %) (for 21 days) | 102616 | standard rat chow (for 98 days) | | | controlled sodium content diet (4 %) (for 21 days) |

9 | heart rate | LH/MavRrrcAek | male | 319.2 | beats/min | standard rat chow (for 98 days) then controlled sodium content diet (4 %) (for 21 days) | 102615 | standard rat chow (for 98 days) | | | controlled sodium content diet (4 %) (for 21 days) |

14 | heart rate | LN/MavRrrcAek | male | 359 | beats/min | standard rat chow (for 98 days) | 102614 | standard rat chow (for 98 days) | | | |

9 | heart rate | LH/MavRrrcAek | male | 326.5 | beats/min | standard rat chow (for 98 days) | 102613 | standard rat chow (for 98 days) | | | |

8 | creatinine clearance | WKY/NHsd | male | 3.1 | ml/min | standard rat chow (for 8 days) then sunitinib (7 mg/kg/d) (for 8 days) | 99180 | standard rat chow (for 8 days) | | | sunitinib (7 mg/kg/d) (for 8 days) |

7 | creatinine clearance | WKY/NHsd | male | 3.1 | ml/min | standard rat chow (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) | 99179 | standard rat chow (for 8 days) | | | vehicle control condition (0.5 ml) (for 8 days) |

14 | plasma triglyceride level | LN/MavRrrcAek | male | 0.39 | mmol/l | standard rat chow (for 98 days) then controlled sodium content diet (4 %) (for 28 days) | 102630 | standard rat chow (for 98 days) | | | controlled sodium content diet (4 %) (for 28 days) |

9 | plasma triglyceride level | LH/MavRrrcAek | male | 0.91 | mmol/l | standard rat chow (for 98 days) then controlled sodium content diet (4 %) (for 28 days) | 102629 | standard rat chow (for 98 days) | | | controlled sodium content diet (4 %) (for 28 days) |

14 | plasma triglyceride level | LN/MavRrrcAek | male | 0.4 | mmol/l | standard rat chow (for 98 days) then controlled sodium content diet (4 %) (for 14 days) | 102628 | standard rat chow (for 98 days) | | | controlled sodium content diet (4 %) (for 14 days) |

9 | plasma triglyceride level | LH/MavRrrcAek | male | 0.43 | mmol/l | standard rat chow (for 98 days) then controlled sodium content diet (4 %) (for 14 days) | 102627 | standard rat chow (for 98 days) | | | controlled sodium content diet (4 %) (for 14 days) |

14 | plasma triglyceride level | LN/MavRrrcAek | male | 0.47 | mmol/l | standard rat chow (for 84 days) | 102626 | standard rat chow (for 84 days) | | | |

9 | plasma triglyceride level | LH/MavRrrcAek | male | 0.56 | mmol/l | standard rat chow (for 84 days) | 102625 | standard rat chow (for 84 days) | | | |

8 | plasma potassium level | WKY/NHsd | male | 4.2 | mmol/l | standard rat chow (for 8 days) then sunitinib (7 mg/kg/d) (for 8 days) | 99164 | standard rat chow (for 8 days) | | | sunitinib (7 mg/kg/d) (for 8 days) |

7 | plasma potassium level | WKY/NHsd | male | 3.9 | mmol/l | standard rat chow (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) | 99163 | standard rat chow (for 8 days) | | | vehicle control condition (0.5 ml) (for 8 days) |

8 | body weight | SBH/Ygl | male | 359 | g | sham surgical control condition (for 56 days) and water (for 56 days) and standard rat chow (for 56 days) | 106643 | sham surgical control condition (for 56 days) | water (for 56 days) | standard rat chow (for 56 days) | |

8 | body weight | SBN/Ygl | male | 328 | g | sham surgical control condition (for 56 days) and water (for 56 days) and standard rat chow (for 56 days) | 106640 | sham surgical control condition (for 56 days) | water (for 56 days) | standard rat chow (for 56 days) | |

4 | body weight | F344-Hsd11b2em1Jmul+/+ | female | 190.5 | g | standard rat chow | 104992 | standard rat chow | | | |

5 | body weight | F344-Hsd11b2em1Jmul-/- | female | 166.2 | g | standard rat chow | 104991 | standard rat chow | | | |

9 | body weight | F344-Hsd11b2em1Jmul+/+ | male | 319.8 | g | standard rat chow | 104990 | standard rat chow | | | |

7 | body weight | F344-Hsd11b2em1Jmul-/- | male | 276.7 | g | standard rat chow | 104989 | standard rat chow | | | |

14 | plasma total cholesterol level | LN/MavRrrcAek | male | 71.8146 | mg/dl | standard rat chow (for 98 days) then controlled sodium content diet (4 %) (for 28 days) | 102636 | standard rat chow (for 98 days) | | | controlled sodium content diet (4 %) (for 28 days) |

9 | plasma total cholesterol level | LH/MavRrrcAek | male | 81.4671 | mg/dl | standard rat chow (for 98 days) then controlled sodium content diet (4 %) (for 28 days) | 102635 | standard rat chow (for 98 days) | | | controlled sodium content diet (4 %) (for 28 days) |

14 | plasma total cholesterol level | LN/MavRrrcAek | male | 42.471 | mg/dl | standard rat chow (for 98 days) then controlled sodium content diet (4 %) (for 14 days) | 102634 | standard rat chow (for 98 days) | | | controlled sodium content diet (4 %) (for 14 days) |

9 | plasma total cholesterol level | LH/MavRrrcAek | male | 62.5482 | mg/dl | standard rat chow (for 98 days) then controlled sodium content diet (4 %) (for 14 days) | 102633 | standard rat chow (for 98 days) | | | controlled sodium content diet (4 %) (for 14 days) |

14 | plasma total cholesterol level | LN/MavRrrcAek | male | 42.0849 | mg/dl | standard rat chow (for 84 days) | 102632 | standard rat chow (for 84 days) | | | |

9 | plasma total cholesterol level | LH/MavRrrcAek | male | 59.4594 | mg/dl | standard rat chow (for 84 days) | 102631 | standard rat chow (for 84 days) | | | |

8 | skin potassium level to skin water level ratio | WKY/NHsd | male | 75 | mmol/l | standard rat chow (for 8 days) then sunitinib (7 mg/kg/d) (for 8 days) | 99156 | standard rat chow (for 8 days) | | | sunitinib (7 mg/kg/d) (for 8 days) |

7 | skin potassium level to skin water level ratio | WKY/NHsd | male | 80 | mmol/l | standard rat chow (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) | 99155 | standard rat chow (for 8 days) | | | vehicle control condition (0.5 ml) (for 8 days) |

8 | skin potassium level plus skin sodium level to skin water level ratio | WKY/NHsd | male | 0.167 | | standard rat chow (for 8 days) then sunitinib (7 mg/kg/d) (for 8 days) | 99144 | standard rat chow (for 8 days) | | | sunitinib (7 mg/kg/d) (for 8 days) |

7 | skin potassium level plus skin sodium level to skin water level ratio | WKY/NHsd | male | 0.17 | | standard rat chow (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) | 99143 | standard rat chow (for 8 days) | | | vehicle control condition (0.5 ml) (for 8 days) |

8 | plasma cystatin C level | WKY/NHsd | male | 4.7 | mg/l | standard rat chow (for 8 days) then sunitinib (7 mg/kg/d) (for 8 days) | 99176 | standard rat chow (for 8 days) | | | sunitinib (7 mg/kg/d) (for 8 days) |

7 | plasma cystatin C level | WKY/NHsd | male | 4 | mg/l | standard rat chow (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) | 99175 | standard rat chow (for 8 days) | | | vehicle control condition (0.5 ml) (for 8 days) |

8 | urine sodium excretion rate | WKY/NHsd | male | 1.1 | mEq/d | standard rat chow (for 8 days) then sunitinib (7 mg/kg/d) (for 8 days) | 99184 | standard rat chow (for 8 days) | | | sunitinib (7 mg/kg/d) (for 8 days) |

7 | urine sodium excretion rate | WKY/NHsd | male | 1 | mEq/d | standard rat chow (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) | 99183 | standard rat chow (for 8 days) | | | vehicle control condition (0.5 ml) (for 8 days) |

8 | skin water level to skin dry weight ratio | WKY/NHsd | male | 1.208 | ml/g | standard rat chow (for 8 days) then sunitinib (7 mg/kg/d) (for 8 days) | 99140 | standard rat chow (for 8 days) | | | sunitinib (7 mg/kg/d) (for 8 days) |

7 | skin water level to skin dry weight ratio | WKY/NHsd | male | 1.223 | ml/g | standard rat chow (for 8 days) then sunitinib (0.5 ml) (for 8 days) | 99139 | standard rat chow (for 8 days) | | | sunitinib (0.5 ml) (for 8 days) |

8 | skin sodium level to skin dry weight ratio | WKY/NHsd | male | 0.112 | REQUEST NEW VALUE | standard rat chow (for 8 days) then sunitinib (7 mg/kg/d) (for 8 days) | 99132 | standard rat chow (for 8 days) | | | sunitinib (7 mg/kg/d) (for 8 days) |

7 | skin sodium level to skin dry weight ratio | WKY/NHsd | male | 0.11 | REQUEST NEW VALUE | standard rat chow (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) | 99131 | standard rat chow (for 8 days) | | | vehicle control condition (0.5 ml) (for 8 days) |

8 | skin chloride level to skin dry weight ratio | WKY/NHsd | male | 0.052 | mmol/g | standard rat chow (for 8 days) then sunitinib (7 mg/kg/d) (for 8 days) | 99136 | standard rat chow (for 8 days) | | | sunitinib (7 mg/kg/d) (for 8 days) |

7 | skin chloride level to skin dry weight ratio | WKY/NHsd | male | 0.051 | mmol/g | standard rat chow (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) | 99135 | standard rat chow (for 8 days) | | | vehicle control condition (0.5 ml) (for 8 days) |

8 | skin chloride level to skin water level ratio | WKY/NHsd | male | 43 | mmol/l | standard rat chow (for 8 days) then sunitinib (7 mg/kg/d) (for 8 days) | 99152 | standard rat chow (for 8 days) | | | sunitinib (7 mg/kg/d) (for 8 days) |

7 | skin chloride level to skin water level ratio | WKY/NHsd | male | 42 | mmol/l | standard rat chow (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) | 99151 | standard rat chow (for 8 days) | | | vehicle control condition (0.5 ml) (for 8 days) |

8 | skin chloride level to skin water level ratio | WKY/NHsd | male | 92 | mmol/l | standard rat chow (for 8 days) then sunitinib (7 mg/kg/d) (for 8 days) | 99148 | standard rat chow (for 8 days) | | | sunitinib (7 mg/kg/d) (for 8 days) |

7 | skin chloride level to skin water level ratio | WKY/NHsd | male | 90 | mmol/l | standard rat chow (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) | 99147 | standard rat chow (for 8 days) | | | vehicle control condition (0.5 ml) (for 8 days) |