Phenominer Database Results (166 results)

 

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Strain Phenotype Conditions Study Experiment Name Sex Age # of Animals Formula Value Units SEM SD Method Method Duration Post Insult Time Value Clinical Measurement Notes Experiment Notes Record ID Study ID
SS-Chr 2BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 12 123.29 mmHg 4.45 15.41 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14378 381
SS-Chr 2BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 12 0.32 ml 0.03 0.09 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15256 381
SS-Chr 2BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 13 0.44 ml 0.02 0.09 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15260 381
SS-Chr 2BN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 9 7.53 null 0.01 0.04 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17088 381
SS-Chr 2BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 13 110.22 % 4.16 15.01 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54014 381
SS-Chr 2BN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 9 0.05 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19824 381
SS-Chr 2BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 12 35.35 ml/min 3.28 11.35 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18685 381
SS-Chr 2BN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 11 -47.67 mmHg 1.24 4.1 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19511 381
SS-Chr 2BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 10 1140.1 s 35.39 111.91 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50250 461
SS-Chr 2BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount female 77 days-91 days 10 109.5 mmol/l 0.48 1.51 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39140 401
SS-Chr 2BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77 days-91 days 10 16.0 mmol/l 0.61 1.94 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42085 401
SS-Chr 2BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77 days-91 days 10 0.46 x 1000 cells/ul 0.09 0.28 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43247 401
SS-Chr 2BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77 days-91 days 10 23.5 mg/dl 0.83 2.64 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40851 401
SS-Chr 2BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 15 7.63 x 1000 cells/ul 0.42 1.64 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40953 401
SS-Chr 2BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 15 2.75 g/dl 0.14 0.53 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40577 401
SS-Chr 2BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 16 0.18 mmHg x min x kg x ml-1 0.01 0.04 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59574 526
SS-Chr 2BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass male 77 days-91 days 16 1.18 g/kg 0.03 0.11 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59684 526
SS-Chr 2BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 9 5.27 mmol/l 0.22 0.65 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38093 401
SS-Chr 2BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 41.31 mmHg 5.41 17.11 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46440 461
SS-Chr 2BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 10 209.89 beats/min 13.97 44.19 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47605 461
SS-Chr 2BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 50.41 ml/min/kg 4.22 13.34 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58022 526
SS-Chr 2BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 12 37.1 degrees C 0.27 0.93 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16595 381
SS-Chr 2BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 16 0.03 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58516 526
SS-Chr 2BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass male 77 days-91 days 16 0.34 null 0.03 0.1 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58760 526
SS-Chr 2BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 10 6.99 g/kg 0.1 0.33 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45675 461
SS-Chr 2BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 6.11 mmHg 0.15 0.42 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47224 461
SS-Chr 2BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 12 116.59 % 5.53 19.17 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53910 381
SS-Chr 2BN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 11 0.05 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19830 381
SS-Chr 2BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 12 104.14 breaths/min 6.17 21.36 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14817 381
SS-Chr 2BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 12 451.08 beats/min 16.57 57.41 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17551 381
SS-Chr 2BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77 days-91 days 10 0.28 mg/dl 0.03 0.09 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39599 401
SS-Chr 2BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 10 5.99 % 1.93 6.1 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49725 461
SS-Chr 2BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 7 155.92 mmHg 10.04 26.56 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48651 461
SS-Chr 2BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 10 121.23 mmHg 6.91 21.84 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14371 381
SS-Chr 2BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 13 %change=VE during 2-3 min hypoxia/control during standard conditions 138.21 % 7.07 25.5 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13707 381
SS-Chr 2BN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 11 -4.61 mmHg 0.42 1.39 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19680 381
SS-Chr 2BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 15 6.51 g/dl 0.13 0.49 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36989 401
SS-Chr 2BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 10 412.88 beats/min 24.38 77.08 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17544 381
SS-Chr 2BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 11 56.5 mmHg 1.41 4.69 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20523 381
SS-Chr 2BN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 9 -48.02 mmHg 1.86 5.59 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19504 381
SS-Chr 2BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass female 49 days-63 days 10 131.0 g 2.0 6.3 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49577 461
SS-Chr 2BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 10 44.4 mmHg 4.13 13.06 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50020 461
SS-Chr 2BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 10 58.0 mmHg 6.97 22.04 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50024 461
SS-Chr 2BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 10 57.17 % 0.47 1.49 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39014 401
SS-Chr 2BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount female 77 days-91 days 10 4.08 g/dl 0.03 0.09 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42256 401
SS-Chr 2BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77 days-91 days 15 1.37 x 1000 cells/ul 0.2 0.76 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43251 401
SS-Chr 2BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 14 0.27 mg/dl 0.02 0.06 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39603 401
SS-Chr 2BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 7 1.54 mg/kg 0.23 0.62 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58929 526
SS-Chr 2BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass male 77 days-91 days 16 210.1 g 7.5 30.0 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59089 526
SS-Chr 2BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77 days-91 days 15 58.69 % 0.92 3.58 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59284 526
SS-Chr 2BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount female 77 days-91 days 10 2.28 g/dl 0.16 0.51 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40573 401
SS-Chr 2BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77 days-91 days 12 20.08 mg/dl 1.22 4.21 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40855 401
SS-Chr 2BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 15 18.7 g/dl 0.28 1.09 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 37995 401
SS-Chr 2BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 13 31.38 mmol/l 1.51 5.45 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38288 401
SS-Chr 2BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77 days-91 days 15 0.02 x 1000 cells/ul 0.01 0.04 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41674 401
SS-Chr 2BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 16 37.8 ml/min/kg 2.34 9.36 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58026 526
SS-Chr 2BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 0.25 null 0.04 0.11 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58136 526
SS-Chr 2BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 7.37 ml/min/g 0.83 2.61 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44741 461
SS-Chr 2BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 12 33.55 ml/min 3.83 13.27 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20231 381
SS-Chr 2BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 13 117.6 % 4.88 17.61 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53913 381
SS-Chr 2BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount female 82 days-99 days 9 27.26 mmHg 1.04 3.12 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17281 381
SS-Chr 2BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 10 846.4 s 64.88 205.18 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49322 461
SS-Chr 2BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 15 0.5 x 1000 cells/ul 0.06 0.24 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39701 401
SS-Chr 2BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass female 77 days-91 days 10 0.25 null 0.02 0.07 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58756 526
SS-Chr 2BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity female 77 days-91 days 10 57.17 % 0.47 1.49 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59280 526
SS-Chr 2BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 80.56 % 4.79 15.15 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48779 461
SS-Chr 2BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 12 0.36 ml 0.03 0.1 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13946 381
SS-Chr 2BN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 9 -5.97 mmHg 0.73 2.2 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19673 381
SS-Chr 2BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 9 56.06 mmHg 1.74 5.22 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20516 381
SS-Chr 2BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 12 97.23 breaths/min 3.3 11.42 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18288 381
SS-Chr 2BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 13 0.05 degrees C 0.14 0.51 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20336 381
SS-Chr 2BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 15 9.31 x 10E6 cells/ul 0.15 0.57 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39264 401
SS-Chr 2BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 15 79.0 U/l 3.91 15.13 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42797 401
SS-Chr 2BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 12 115.71 % 6.49 22.49 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54351 381
SS-Chr 2BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 10 32.0 g/dl 0.16 0.51 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39800 401
SS-Chr 2BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 15 31.85 g/dl 0.11 0.41 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39804 401
SS-Chr 2BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 11 1.73 mg/kg 0.14 0.46 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58933 526
SS-Chr 2BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 10 18.3 g/dl 0.21 0.67 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 37991 401
SS-Chr 2BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass female 77 days-91 days 10 1.46 g/kg 0.03 0.09 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59680 526
SS-Chr 2BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77 days-91 days 10 0.03 x 1000 cells/ul 0.01 0.04 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41670 401
SS-Chr 2BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 10 0.54 IU/g 0.09 0.3 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47510 461
SS-Chr 2BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77 days-91 days 10 0.11 mg/dl 0.01 0.03 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41891 401
SS-Chr 2BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 15 0.1 mg/dl 0.0 0.0 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41895 401
SS-Chr 2BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 49.04 mmHg 6.1 19.3 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46444 461
SS-Chr 2BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 11.62 ml/min/kg 1.2 3.78 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57621 526
SS-Chr 2BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 13 37.38 degrees C 0.12 0.42 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16599 381
SS-Chr 2BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 16 0.37 null 0.03 0.12 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58140 526
SS-Chr 2BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 159.65 mmHg 8.57 25.7 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45752 461
SS-Chr 2BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 158.91 mmHg 9.27 26.22 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45756 461
SS-Chr 2BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 68.15 mmHg 11.65 36.84 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45297 461
SS-Chr 2BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 10 6.36 g/dl 0.15 0.46 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36985 401
SS-Chr 2BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 10 174.67 beats/min 14.84 46.94 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45171 461
SS-Chr 2BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 10 1.94 % 0.6 1.9 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49721 461
SS-Chr 2BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77 days-91 days 10 48.8 U/l 3.92 12.38 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40737 401
SS-Chr 2BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount female 77 days-91 days 10 4.29 mmol/l 0.08 0.26 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38089 401
SS-Chr 2BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 12 %change=VE during 2-3 min hypoxia/control during standard conditions 132.84 % 6.34 21.95 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13703 381
SS-Chr 2BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 13 115.01 % 2.92 10.54 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53781 381
SS-Chr 2BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 12 103.24 % 5.3 18.37 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54011 381
SS-Chr 2BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 15 249.33 U/l 8.98 34.78 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36406 401
SS-Chr 2BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 15 79.93 mg/dl 1.96 7.59 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37124 401
SS-Chr 2BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 12 9.47 mg/dl 0.11 0.37 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36651 401
SS-Chr 2BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 13 103.16 breaths/min 2.39 8.63 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18292 381
SS-Chr 2BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 12 -0.53 degrees C 0.29 1.0 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20332 381
SS-Chr 2BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 15 58.69 % 0.92 3.58 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39018 401
SS-Chr 2BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 15 63.15 fl 0.52 2.0 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38772 401
SS-Chr 2BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 15 107.13 mmol/l 1.29 5.0 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39144 401
SS-Chr 2BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 15 20.1 pg 0.15 0.57 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42572 401
SS-Chr 2BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount female 77 days-91 days 10 146.0 mmol/l 0.45 1.41 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39411 401
SS-Chr 2BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 15 146.27 mmol/l 0.48 1.87 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39415 401
SS-Chr 2BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 13 118.05 % 5.02 18.1 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54354 381
SS-Chr 2BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 15 52.33 U/l 2.24 8.66 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40741 401
SS-Chr 2BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77 days-91 days 10 5.11 x 1000 cells/ul 0.24 0.77 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40949 401
SS-Chr 2BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 15 8.82 mg/dl 0.14 0.54 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37621 401
SS-Chr 2BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77 days-91 days 10 4.26 x 1000 cells/ul 0.19 0.62 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41526 401
SS-Chr 2BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 15 5.73 x 1000 cells/ul 0.32 1.25 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41530 401
SS-Chr 2BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77 days-91 days 10 24.8 mmol/l 0.66 2.1 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38284 401
SS-Chr 2BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 8 159.27 mmHg 6.89 19.5 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48647 461
SS-Chr 2BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 10 0.92 g 0.02 0.07 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45428 461
SS-Chr 2BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount female 77 days-91 days 10 148.7 mg/dl 5.96 18.84 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38553 401
SS-Chr 2BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 230.53 beats/min 8.76 27.71 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47609 461
SS-Chr 2BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 54.93 % 5.3 16.76 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48550 461
SS-Chr 2BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 42.51 % 4.93 15.6 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48554 461
SS-Chr 2BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 12.22 ml/min/kg 1.35 4.26 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57823 526
SS-Chr 2BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 16 13.41 ml/min/kg 0.86 3.43 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57827 526
SS-Chr 2BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 6.52 ml/min/g 0.72 2.27 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44745 461
SS-Chr 2BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 52.52 % 3.24 10.24 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47100 461
SS-Chr 2BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 83.27 % 4.0 12.65 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48318 461
SS-Chr 2BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 12 123.34 % 8.05 27.88 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53778 381
SS-Chr 2BN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 11 7.5 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17094 381
SS-Chr 2BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 13 0.47 ml 0.04 0.14 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13950 381
SS-Chr 2BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 115.87 mmHg 11.06 34.98 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49911 461
SS-Chr 2BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 117.19 mmHg 14.7 46.47 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49915 461
SS-Chr 2BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 10 0.44 IU/g 0.11 0.35 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47502 461
SS-Chr 2BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 70.72 % 3.38 10.69 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48783 461
SS-Chr 2BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 16 11.32 ml/min/kg 0.47 1.9 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57625 526
SS-Chr 2BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77 days-91 days 10 8.44 mg/dl 0.28 0.9 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37617 401
SS-Chr 2BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 10 19.96 pg 0.15 0.48 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42568 401
SS-Chr 2BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 13 101.38 breaths/min 2.9 10.46 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14821 381
SS-Chr 2BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77 days-91 days 10 160.9 U/l 9.51 30.06 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36402 401
SS-Chr 2BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount male 82 days-99 days 11 27.69 mmHg 1.06 3.5 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17288 381
SS-Chr 2BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount female 77 days-91 days 10 9.01 mg/dl 0.11 0.34 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36647 401
SS-Chr 2BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 13 44.29 ml/min 2.89 10.43 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20235 381
SS-Chr 2BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass male 49 days-63 days 10 154.1 g 4.4 14.0 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49585 461
SS-Chr 2BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 1105.2 s 28.59 90.41 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50254 461
SS-Chr 2BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 13 14.92 mmol/l 0.4 1.44 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42089 401
SS-Chr 2BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 15 3.76 g/dl 0.04 0.14 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42260 401
SS-Chr 2BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77 days-91 days 10 62.46 fl 0.45 1.41 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38768 401
SS-Chr 2BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77 days-91 days 10 85.0 U/l 8.57 27.09 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42793 401
SS-Chr 2BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity female 77 days-91 days 10 0.36 x 1000 cells/ul 0.06 0.19 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39697 401
SS-Chr 2BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass female 77 days-91 days 10 145.5 g 2.3 7.2 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59085 526
SS-Chr 2BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 10 0.95 g 0.03 0.08 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45432 461
SS-Chr 2BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77 days-91 days 10 0.02 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58512 526
SS-Chr 2BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 10 6.15 g/kg 0.12 0.38 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45683 461
SS-Chr 2BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 14.1 ml/min/g 1.29 4.07 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46676 461
SS-Chr 2BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 12.68 ml/min/g 0.99 3.13 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46680 461
SS-Chr 2BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 52.88 % 4.88 15.43 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47104 461
SS-Chr 2BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 8 6.39 mmHg 0.15 0.44 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47220 461
SS-Chr 2BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 74.56 mmHg 9.82 31.06 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45293 461
SS-Chr 2BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 86.63 % 3.63 11.47 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48322 461
SS-Chr 2BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 13 48.77 ml/min 4.43 15.97 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18689 381
SS-Chr 2BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77 days-91 days 10 83.6 mg/dl 3.33 10.54 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37120 401
SS-Chr 2BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 198.22 beats/min 8.25 26.1 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45175 461
SS-Chr 2BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount male 77 days-91 days 15 158.47 mg/dl 5.61 21.74 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38557 401
SS-Chr 2BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 10 904.2 s 30.66 96.96 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49326 461
SS-Chr 2BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 10 9.16 x 10E6 cells/ul 0.11 0.33 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39260 401
SS-Chr 2BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 0.16 mmHg x min x kg x ml-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59570 526