FHH-Chr 7BN/Mcwi |
tidal volume |
controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) |
PhysGen Respiratory data |
pulmonary ventilation trait |
female |
82 days-99 days |
11 |
|
0.31 |
ml |
0.04 |
0.12 |
stop flow air displacement plethysmography |
|
0 |
|
Moms and pups used in studies were fed Teklad |
15311 |
381 |
FHH-Chr 7BN/Mcwi |
percent change in respiration rate |
controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) |
PhysGen Respiratory data |
respiratory function trait |
female |
82 days-99 days |
11 |
|
124.01 |
% |
12.71 |
42.16 |
stop flow air displacement plethysmography |
|
0 |
|
Moms and pups used in studies were fed Teklad |
53830 |
381 |
FHH-Chr 7BN/Mcwi |
absolute change in partial pressure of blood carbon dioxide |
controlled air oxygen content (12 %) (for 0.1 hours) |
PhysGen Respiratory data |
blood carbon dioxide amount |
female |
82 days-99 days |
3 |
|
-9.83 |
mmHg |
1.39 |
2.4 |
automated blood gas analysis using a Bayer analyzer |
|
0 |
|
Moms and pups used in studies were fed Teklad |
19672 |
381 |
FHH-Chr 7BN/Mcwi |
absolute change in partial pressure of blood carbon dioxide |
controlled air oxygen content (12 %) (for 0.1 hours) |
PhysGen Respiratory data |
blood carbon dioxide amount |
male |
82 days-99 days |
2 |
|
-5.0 |
mmHg |
1.1 |
1.56 |
automated blood gas analysis using a Bayer analyzer |
|
0 |
|
Moms and pups used in studies were fed Teklad |
19679 |
381 |
FHH-Chr 7BN/Mcwi |
minute ventilation |
controlled air oxygen content (12 %) (between 0 and 0.1 hours) |
PhysGen Respiratory data |
pulmonary ventilation trait |
male |
82 days-99 days |
8 |
|
26.55 |
ml/min |
2.74 |
7.75 |
stop flow air displacement plethysmography |
|
0 |
|
Moms and pups used in studies were fed Teklad |
18745 |
381 |
FHH-Chr 7BN/Mcwi |
heart rate |
controlled air oxygen content (12 %) (for 0.1 hours) |
PhysGen Respiratory data |
heart pumping trait |
male |
82 days-99 days |
3 |
|
428.88 |
beats/min |
19.96 |
34.57 |
vascular fluid filled catheter |
|
0 |
|
Moms and pups used in studies were fed Teklad |
17550 |
381 |
FHH-Chr 7BN/Mcwi |
absolute change in partial pressure of blood oxygen |
controlled air oxygen content (12 %) (for 0.1 hours) |
PhysGen Respiratory data |
blood oxygen amount |
male |
82 days-99 days |
2 |
|
-43.5 |
mmHg |
4.3 |
6.08 |
automated blood gas analysis using a Bayer analyzer |
|
0 |
|
Moms and pups used in studies were fed Teklad |
19510 |
381 |
FHH-Chr 7BN/Mcwi |
minute ventilation |
controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) |
PhysGen Respiratory data |
pulmonary ventilation trait |
male |
82 days-99 days |
8 |
|
24.41 |
ml/min |
2.47 |
6.98 |
stop flow air displacement plethysmography |
|
0 |
|
Moms and pups used in studies were fed Teklad |
20291 |
381 |
FHH-Chr 7BN/Mcwi |
time to onset of heart contraction |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) |
PhysGen Cardiac data |
heart muscle contractility trait |
female |
49 days-63 days |
10 |
|
1013.7 |
s |
37.05 |
117.17 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
Moms and pups used in studies were fed Teklad |
49375 |
461 |
FHH-Chr 7BN/Mcwi |
heart contraction pressure |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) |
PhysGen Cardiac data |
heart muscle contractility trait |
female |
49 days-63 days |
10 |
|
32.8 |
mmHg |
2.61 |
8.24 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
Moms and pups used in studies were fed Teklad |
50073 |
461 |
FHH-Chr 7BN/Mcwi |
mean corpuscular volume |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
erythrocyte size trait |
male |
77 days-91 days |
10 |
|
58.75 |
fl |
0.66 |
2.07 |
automated blood cell counting method |
|
0 |
|
Moms and pups used in studies were fed Teklad |
38827 |
401 |
FHH-Chr 7BN/Mcwi |
serum bicarbonate level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood bicarbonate amount |
male |
77 days-91 days |
10 |
|
17.5 |
mmol/l |
0.82 |
2.59 |
standard blood chemistry panel |
|
0 |
|
Moms and pups used in studies were fed Teklad |
42144 |
401 |
FHH-Chr 7BN/Mcwi |
hematocrit |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
erythrocyte quantity |
female |
77 days-91 days |
10 |
|
52.25 |
% |
0.56 |
1.78 |
automated blood cell counting method |
|
0 |
|
Moms and pups used in studies were fed Teklad |
39068 |
401 |
FHH-Chr 7BN/Mcwi |
serum sodium level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood sodium amount |
male |
77 days-91 days |
10 |
|
141.8 |
mmol/l |
0.66 |
2.1 |
standard blood chemistry panel |
|
0 |
|
Moms and pups used in studies were fed Teklad |
39470 |
401 |
FHH-Chr 7BN/Mcwi |
percent change in respiration rate |
controlled air oxygen content (12 %) (between 0 and 0.1 hours) |
PhysGen Respiratory data |
respiratory function trait |
male |
82 days-99 days |
8 |
|
124.2 |
% |
5.3 |
14.98 |
stop flow air displacement plethysmography |
|
0 |
|
Moms and pups used in studies were fed Teklad |
54407 |
381 |
FHH-Chr 7BN/Mcwi |
hematocrit |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Lung data |
erythrocyte quantity |
male |
77 days-91 days |
10 |
|
55.68 |
% |
0.65 |
2.06 |
microhematocrit tube assay with visual assessment |
|
0 |
|
Moms and pups used in studies were fed Teklad |
59339 |
526 |
FHH-Chr 7BN/Mcwi |
serum phosphate level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood phosphate amount |
male |
77 days-91 days |
10 |
|
9.56 |
mg/dl |
0.29 |
0.91 |
standard blood chemistry panel |
|
0 |
|
Moms and pups used in studies were fed Teklad |
37676 |
401 |
FHH-Chr 7BN/Mcwi |
serum urea nitrogen level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood urea nitrogen amount |
female |
77 days-91 days |
10 |
|
19.7 |
mg/dl |
0.93 |
2.95 |
standard blood chemistry panel |
|
0 |
|
Moms and pups used in studies were fed Teklad |
40905 |
401 |
FHH-Chr 7BN/Mcwi |
serum urea nitrogen level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood urea nitrogen amount |
male |
77 days-91 days |
10 |
|
23.0 |
mg/dl |
1.03 |
3.27 |
standard blood chemistry panel |
|
0 |
|
Moms and pups used in studies were fed Teklad |
40910 |
401 |
FHH-Chr 7BN/Mcwi |
lung dry weight to body weight ratio |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Lung data |
lung mass |
female |
77 days-91 days |
10 |
|
1.9 |
g/kg |
0.04 |
0.14 |
digital scale post excision weight measurement |
|
0 |
|
Moms and pups used in studies were fed Teklad |
59734 |
526 |
FHH-Chr 7BN/Mcwi |
heart wet weight |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Cardiac data |
heart mass |
male |
49 days-63 days |
10 |
|
1.04 |
g |
0.04 |
0.14 |
digital scale post excision weight measurement |
|
0 |
|
Moms and pups used in studies were fed Teklad |
45486 |
461 |
FHH-Chr 7BN/Mcwi |
left ventricular diastolic blood pressure |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) |
PhysGen Cardiac data |
heart left ventricular blood pressure trait |
female |
49 days-63 days |
10 |
|
45.31 |
mmHg |
3.5 |
11.06 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
Moms and pups used in studies were fed Teklad |
46493 |
461 |
FHH-Chr 7BN/Mcwi |
left ventricular developed pressure |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) |
PhysGen Cardiac data |
heart left ventricular blood pressure trait |
male |
49 days-63 days |
10 |
|
109.79 |
mmHg |
8.08 |
25.54 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
Moms and pups used in studies were fed Teklad |
48705 |
461 |
FHH-Chr 7BN/Mcwi |
percent change in left ventricular systolic blood pressure |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) |
PhysGen Cardiac data |
heart pumping trait |
female |
49 days-63 days |
10 |
post-ischemic value/pre-ischemic value x 100% |
81.14 |
% |
3.08 |
9.73 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
Moms and pups used in studies were fed Teklad |
48832 |
461 |
FHH-Chr 7BN/Mcwi |
body temperature |
controlled air oxygen content (12 %) (for 0.1 hours) |
PhysGen Respiratory data |
body temperature trait |
male |
82 days-99 days |
9 |
|
37.41 |
degrees C |
0.22 |
0.65 |
digital rectal thermometry |
|
0 |
|
Moms and pups used in studies were fed Teklad |
16655 |
381 |
FHH-Chr 7BN/Mcwi |
methylene blue to FAPGG metabolism-surface area product ratio |
controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) |
PhysGen Lung data |
pulmonary blood flow trait |
female |
77 days-91 days |
6 |
|
0.46 |
null |
0.02 |
0.06 |
isolated perfused lung vascular effluent collection |
|
0 |
|
Moms and pups used in studies were fed Teklad |
58190 |
526 |
FHH-Chr 7BN/Mcwi |
heart effluent lactate dehydrogenase activity level normalized to heart weight |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) |
PhysGen Cardiac data |
heart lactate dehydrogenase activity |
female |
49 days-63 days |
10 |
|
20.84 |
IU/g |
1.94 |
6.12 |
isolated perfused heart effluent collection |
|
0 |
|
Moms and pups used in studies were fed Teklad |
46008 |
461 |
FHH-Chr 7BN/Mcwi |
absolute change in body temperature |
controlled air oxygen content (12 %) (for 0.1 hours) |
PhysGen Respiratory data |
body temperature trait |
male |
82 days-99 days |
9 |
|
0.24 |
degrees C |
0.2 |
0.61 |
digital rectal thermometry |
|
0 |
|
Moms and pups used in studies were fed Teklad |
20392 |
381 |
FHH-Chr 7BN/Mcwi |
mean arterial blood pressure |
controlled air oxygen content (12 %) (for 0.1 hours) |
PhysGen Respiratory data |
arterial blood pressure trait |
female |
82 days-99 days |
3 |
|
119.96 |
mmHg |
9.79 |
16.96 |
vascular fluid filled catheter |
|
0 |
|
Moms and pups used in studies were fed Teklad |
14370 |
381 |
FHH-Chr 7BN/Mcwi |
percent change in arterial blood flow rate |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) |
PhysGen Cardiac data |
arterial blood flow trait |
male |
49 days-63 days |
10 |
post-ischemic value/pre-ischemic value x 100% |
39.21 |
% |
5.97 |
18.87 |
isolated perfused heart effluent collection |
|
0 |
|
Moms and pups used in studies were fed Teklad |
47158 |
461 |
FHH-Chr 7BN/Mcwi |
left ventricular developed pressure |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) |
PhysGen Cardiac data |
heart left ventricular blood pressure trait |
male |
49 days-63 days |
10 |
|
41.23 |
mmHg |
6.35 |
20.07 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
Moms and pups used in studies were fed Teklad |
45351 |
461 |
FHH-Chr 7BN/Mcwi |
serum potassium level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood potassium amount |
male |
77 days-91 days |
10 |
|
5.56 |
mmol/l |
0.23 |
0.72 |
standard blood chemistry panel |
|
0 |
|
Moms and pups used in studies were fed Teklad |
38148 |
401 |
FHH-Chr 7BN/Mcwi |
heart rate |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) |
PhysGen Cardiac data |
heart pumping trait |
male |
49 days-63 days |
10 |
|
255.48 |
beats/min |
6.01 |
18.99 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
Moms and pups used in studies were fed Teklad |
47663 |
461 |
FHH-Chr 7BN/Mcwi |
lung dry weight to body weight ratio |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Lung data |
lung mass |
male |
77 days-91 days |
10 |
|
1.57 |
g/kg |
0.04 |
0.13 |
digital scale post excision weight measurement |
|
0 |
|
Moms and pups used in studies were fed Teklad |
59739 |
526 |
FHH-Chr 7BN/Mcwi |
blood hemoglobin level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood hemoglobin amount |
female |
77 days-91 days |
10 |
|
16.6 |
g/dl |
0.16 |
0.51 |
automated blood cell counting method |
|
0 |
|
Moms and pups used in studies were fed Teklad |
38045 |
401 |
FHH-Chr 7BN/Mcwi |
partial pressure of blood carbon dioxide (Pco2) |
controlled air oxygen content (12 %) (for 0.1 hours) |
PhysGen Respiratory data |
blood gas amount |
male |
82 days-99 days |
2 |
|
31.88 |
mmHg |
1.58 |
2.23 |
automated blood gas analysis using a Bayer analyzer |
|
0 |
|
Moms and pups used in studies were fed Teklad |
17287 |
381 |
FHH-Chr 7BN/Mcwi |
serum alkaline phosphatase activity level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood alkaline phosphatase amount |
male |
77 days-91 days |
10 |
|
339.0 |
U/l |
16.09 |
50.88 |
standard blood chemistry panel |
|
0 |
|
Moms and pups used in studies were fed Teklad |
36461 |
401 |
FHH-Chr 7BN/Mcwi |
serum total protein level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood total protein amount |
female |
77 days-91 days |
10 |
|
5.24 |
g/dl |
0.05 |
0.15 |
standard blood chemistry panel |
|
0 |
|
Moms and pups used in studies were fed Teklad |
37039 |
401 |
FHH-Chr 7BN/Mcwi |
body weight |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Cardiac data |
body mass |
female |
49 days-63 days |
10 |
|
131.5 |
g |
2.7 |
8.6 |
whole body digital scale |
|
0 |
|
Moms and pups used in studies were fed Teklad |
49575 |
461 |
FHH-Chr 7BN/Mcwi |
mean corpuscular volume |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
erythrocyte size trait |
female |
77 days-91 days |
10 |
|
58.88 |
fl |
0.26 |
0.82 |
automated blood cell counting method |
|
0 |
|
Moms and pups used in studies were fed Teklad |
38822 |
401 |
FHH-Chr 7BN/Mcwi |
hematocrit |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
erythrocyte quantity |
male |
77 days-91 days |
10 |
|
55.68 |
% |
0.65 |
2.06 |
automated blood cell counting method |
|
0 |
|
Moms and pups used in studies were fed Teklad |
39073 |
401 |
FHH-Chr 7BN/Mcwi |
serum sodium level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood sodium amount |
female |
77 days-91 days |
10 |
|
140.8 |
mmol/l |
0.77 |
2.44 |
standard blood chemistry panel |
|
0 |
|
Moms and pups used in studies were fed Teklad |
39465 |
401 |
FHH-Chr 7BN/Mcwi |
serum aspartate aminotransferase activity level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood aspartate transaminase amount |
female |
77 days-91 days |
10 |
|
92.1 |
U/l |
6.7 |
21.18 |
standard blood chemistry panel |
|
0 |
|
Moms and pups used in studies were fed Teklad |
42847 |
401 |
FHH-Chr 7BN/Mcwi |
plasma creatinine level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood creatinine amount |
female |
77 days-91 days |
10 |
|
0.33 |
mg/dl |
0.02 |
0.07 |
automated plasma creatinine analysis |
|
0 |
|
Moms and pups used in studies were fed Teklad |
39653 |
401 |
FHH-Chr 7BN/Mcwi |
plasma creatinine level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood creatinine amount |
male |
77 days-91 days |
10 |
|
0.32 |
mg/dl |
0.02 |
0.08 |
automated plasma creatinine analysis |
|
0 |
|
Moms and pups used in studies were fed Teklad |
39658 |
401 |
FHH-Chr 7BN/Mcwi |
dose of methacholine at which pulmonary conductance is half its pretreatment value |
controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) |
PhysGen Lung data |
pulmonary ventilation trait |
male |
77 days-91 days |
10 |
|
2.34 |
mg/kg |
0.46 |
1.46 |
stop flow air displacement plethysmography |
|
0 |
|
Moms and pups used in studies were fed Teklad |
58988 |
526 |
FHH-Chr 7BN/Mcwi |
body weight |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Lung data |
body mass |
female |
77 days-91 days |
10 |
|
176.2 |
g |
2.9 |
9.2 |
whole body digital scale |
|
0 |
|
Moms and pups used in studies were fed Teklad |
59139 |
526 |
FHH-Chr 7BN/Mcwi |
serum globulin level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood globulin amount |
female |
77 days-91 days |
10 |
|
1.32 |
g/dl |
0.03 |
0.09 |
standard blood chemistry panel |
|
0 |
replaced obsolete serum globulin level term, 1/19/2016 |
Moms and pups used in studies were fed Teklad |
40627 |
401 |
FHH-Chr 7BN/Mcwi |
blood lymphocyte count |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
lymphocyte quantity |
female |
77 days-91 days |
10 |
|
4.92 |
x 1000 cells/ul |
0.27 |
0.86 |
automated blood cell counting method |
|
0 |
|
Moms and pups used in studies were fed Teklad |
41580 |
401 |
FHH-Chr 7BN/Mcwi |
serum glucose level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood glucose amount |
male |
77 days-91 days |
10 |
|
155.1 |
mg/dl |
10.51 |
33.22 |
standard blood chemistry panel |
|
0 |
|
Moms and pups used in studies were fed Teklad |
38612 |
401 |
FHH-Chr 7BN/Mcwi |
serum glucose level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood glucose amount |
female |
77 days-91 days |
10 |
|
179.9 |
mg/dl |
14.57 |
46.09 |
standard blood chemistry panel |
|
0 |
|
Moms and pups used in studies were fed Teklad |
38607 |
401 |
FHH-Chr 7BN/Mcwi |
serum total bilirubin level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood bilirubin amount |
male |
77 days-91 days |
10 |
|
0.1 |
mg/dl |
0.01 |
0.02 |
standard blood chemistry panel |
|
0 |
|
Moms and pups used in studies were fed Teklad |
41950 |
401 |
FHH-Chr 7BN/Mcwi |
methylene blue to FAPGG metabolism-surface area product ratio |
controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) |
PhysGen Lung data |
pulmonary blood flow trait |
male |
77 days-91 days |
10 |
|
0.39 |
null |
0.02 |
0.06 |
isolated perfused lung vascular effluent collection |
|
0 |
|
Moms and pups used in studies were fed Teklad |
58195 |
526 |
FHH-Chr 7BN/Mcwi |
heart right ventricle weight to left ventricle weight ratio |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Lung data |
heart right ventricle mass |
male |
77 days-91 days |
10 |
|
0.43 |
null |
0.02 |
0.08 |
digital scale post excision weight measurement |
|
0 |
|
Moms and pups used in studies were fed Teklad |
58815 |
526 |
FHH-Chr 7BN/Mcwi |
heart effluent lactate dehydrogenase activity level normalized to heart weight |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) |
PhysGen Cardiac data |
heart lactate dehydrogenase activity |
male |
49 days-63 days |
10 |
|
13.26 |
IU/g |
2.44 |
7.71 |
isolated perfused heart effluent collection |
|
0 |
|
Moms and pups used in studies were fed Teklad |
46014 |
461 |
FHH-Chr 7BN/Mcwi |
left ventricular diastolic blood pressure |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) |
PhysGen Cardiac data |
heart left ventricular blood pressure trait |
female |
49 days-63 days |
10 |
|
5.13 |
mmHg |
0.23 |
0.72 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
Moms and pups used in studies were fed Teklad |
47273 |
461 |
FHH-Chr 7BN/Mcwi |
left ventricular developed pressure |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) |
PhysGen Cardiac data |
heart left ventricular blood pressure trait |
female |
49 days-63 days |
10 |
|
56.92 |
mmHg |
5.94 |
18.77 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
Moms and pups used in studies were fed Teklad |
45346 |
461 |
FHH-Chr 7BN/Mcwi |
left ventricular systolic blood pressure |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) |
PhysGen Cardiac data |
heart left ventricular blood pressure trait |
female |
49 days-63 days |
10 |
|
126.58 |
mmHg |
4.4 |
13.92 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
Moms and pups used in studies were fed Teklad |
45805 |
461 |
FHH-Chr 7BN/Mcwi |
heart left ventricle infarction weight to total heart left ventricle weight ratio |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) |
PhysGen Cardiac data |
heart left ventricle integrity trait |
female |
49 days-63 days |
10 |
|
3.66 |
% |
1.3 |
4.1 |
digital scale post excision weight measurement |
|
0 |
|
Moms and pups used in studies were fed Teklad |
49774 |
461 |
FHH-Chr 7BN/Mcwi |
percent change in left ventricular systolic blood pressure |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) |
PhysGen Cardiac data |
heart pumping trait |
male |
49 days-63 days |
10 |
post-ischemic value/pre-ischemic value x 100% |
86.82 |
% |
9.05 |
28.6 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
Moms and pups used in studies were fed Teklad |
48837 |
461 |
FHH-Chr 7BN/Mcwi |
serum albumin level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood albumin amount |
male |
77 days-91 days |
10 |
|
3.83 |
g/dl |
0.07 |
0.24 |
standard blood chemistry panel |
|
0 |
|
Moms and pups used in studies were fed Teklad |
42315 |
401 |
FHH-Chr 7BN/Mcwi |
mean arterial blood pressure |
controlled air oxygen content (12 %) (for 0.1 hours) |
PhysGen Respiratory data |
arterial blood pressure trait |
male |
82 days-99 days |
3 |
|
146.22 |
mmHg |
6.39 |
11.06 |
vascular fluid filled catheter |
|
0 |
|
Moms and pups used in studies were fed Teklad |
14377 |
381 |
FHH-Chr 7BN/Mcwi |
percent change in ventilation |
controlled air oxygen content (12 %) (between 0 and 0.1 hours) |
PhysGen Respiratory data |
pulmonary ventilation trait |
female |
82 days-99 days |
11 |
%change=VE during 2-3 min hypoxia/control during standard conditions |
163.49 |
% |
20.03 |
66.44 |
stop flow air displacement plethysmography |
|
0 |
|
Moms and pups used in studies were fed Teklad |
13758 |
381 |
FHH-Chr 7BN/Mcwi |
tidal volume |
controlled air oxygen content (12 %) (between 0 and 0.1 hours) |
PhysGen Respiratory data |
pulmonary ventilation trait |
female |
82 days-99 days |
11 |
|
0.31 |
ml |
0.03 |
0.09 |
stop flow air displacement plethysmography |
|
0 |
|
Moms and pups used in studies were fed Teklad |
14001 |
381 |
FHH-Chr 7BN/Mcwi |
minute ventilation |
controlled air oxygen content (12 %) (between 0 and 0.1 hours) |
PhysGen Respiratory data |
pulmonary ventilation trait |
female |
82 days-99 days |
11 |
|
37.21 |
ml/min |
5.52 |
18.3 |
stop flow air displacement plethysmography |
|
0 |
|
Moms and pups used in studies were fed Teklad |
18740 |
381 |
FHH-Chr 7BN/Mcwi |
serum alkaline phosphatase activity level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood alkaline phosphatase amount |
female |
77 days-91 days |
10 |
|
200.9 |
U/l |
4.51 |
14.25 |
standard blood chemistry panel |
|
0 |
|
Moms and pups used in studies were fed Teklad |
36456 |
401 |
FHH-Chr 7BN/Mcwi |
time to onset of heart contraction |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) |
PhysGen Cardiac data |
heart muscle contractility trait |
male |
49 days-63 days |
10 |
|
893.2 |
s |
72.32 |
228.71 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
Moms and pups used in studies were fed Teklad |
49380 |
461 |
FHH-Chr 7BN/Mcwi |
body weight |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Cardiac data |
body mass |
male |
49 days-63 days |
10 |
|
156.3 |
g |
4.5 |
14.1 |
whole body digital scale |
|
0 |
|
Moms and pups used in studies were fed Teklad |
49583 |
461 |
FHH-Chr 7BN/Mcwi |
serum bicarbonate level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood bicarbonate amount |
female |
77 days-91 days |
10 |
|
19.2 |
mmol/l |
0.39 |
1.23 |
standard blood chemistry panel |
|
0 |
|
Moms and pups used in studies were fed Teklad |
42139 |
401 |
FHH-Chr 7BN/Mcwi |
red blood cell count |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
erythrocyte quantity |
female |
77 days-91 days |
10 |
|
8.87 |
x 10E6 cells/ul |
0.08 |
0.27 |
automated blood cell counting method |
|
0 |
|
Moms and pups used in studies were fed Teklad |
39314 |
401 |
FHH-Chr 7BN/Mcwi |
mean corpuscular hemoglobin |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood hemoglobin amount |
female |
77 days-91 days |
10 |
|
18.73 |
pg |
0.07 |
0.21 |
automated blood cell counting method |
|
0 |
|
Moms and pups used in studies were fed Teklad |
42622 |
401 |
FHH-Chr 7BN/Mcwi |
serum aspartate aminotransferase activity level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood aspartate transaminase amount |
male |
77 days-91 days |
10 |
|
103.4 |
U/l |
7.57 |
23.95 |
standard blood chemistry panel |
|
0 |
|
Moms and pups used in studies were fed Teklad |
42852 |
401 |
FHH-Chr 7BN/Mcwi |
blood neutrophil count |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
neutrophil quantity |
female |
77 days-91 days |
10 |
|
0.47 |
x 1000 cells/ul |
0.09 |
0.29 |
automated blood cell counting method |
|
0 |
|
Moms and pups used in studies were fed Teklad |
43301 |
401 |
FHH-Chr 7BN/Mcwi |
blood neutrophil count |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
neutrophil quantity |
male |
77 days-91 days |
10 |
|
0.91 |
x 1000 cells/ul |
0.13 |
0.42 |
automated blood cell counting method |
|
0 |
|
Moms and pups used in studies were fed Teklad |
43306 |
401 |
FHH-Chr 7BN/Mcwi |
serum globulin level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood globulin amount |
male |
77 days-91 days |
10 |
|
1.45 |
g/dl |
0.05 |
0.16 |
standard blood chemistry panel |
|
0 |
replaced obsolete serum globulin level term, 1/19/2016 |
Moms and pups used in studies were fed Teklad |
40632 |
401 |
FHH-Chr 7BN/Mcwi |
total white blood cell count |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
leukocyte quantity |
female |
77 days-91 days |
10 |
|
5.66 |
x 1000 cells/ul |
0.29 |
0.92 |
automated blood cell counting method |
|
0 |
|
Moms and pups used in studies were fed Teklad |
41003 |
401 |
FHH-Chr 7BN/Mcwi |
total white blood cell count |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
leukocyte quantity |
male |
77 days-91 days |
10 |
|
6.51 |
x 1000 cells/ul |
0.34 |
1.06 |
automated blood cell counting method |
|
0 |
|
Moms and pups used in studies were fed Teklad |
41008 |
401 |
FHH-Chr 7BN/Mcwi |
calculated pulmonary vascular resistance normalized to body weight |
controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) |
PhysGen Lung data |
pulmonary blood flow trait |
male |
77 days-91 days |
10 |
|
0.16 |
mmHg x min x kg x ml-1 |
0.0 |
0.01 |
fluid-filled catheter with pressure transducer in isolated perfused lung |
|
0 |
|
Moms and pups used in studies were fed Teklad |
59629 |
526 |
FHH-Chr 7BN/Mcwi |
serum potassium level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood potassium amount |
female |
77 days-91 days |
10 |
|
4.78 |
mmol/l |
0.17 |
0.55 |
standard blood chemistry panel |
|
0 |
|
Moms and pups used in studies were fed Teklad |
38143 |
401 |
FHH-Chr 7BN/Mcwi |
blood lymphocyte count |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
lymphocyte quantity |
male |
77 days-91 days |
10 |
|
5.27 |
x 1000 cells/ul |
0.28 |
0.88 |
automated blood cell counting method |
|
0 |
|
Moms and pups used in studies were fed Teklad |
41585 |
401 |
FHH-Chr 7BN/Mcwi |
blood eosinophil count |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
eosinophil quantity |
female |
77 days-91 days |
10 |
|
0.06 |
x 1000 cells/ul |
0.02 |
0.05 |
automated blood cell counting method |
|
0 |
|
Moms and pups used in studies were fed Teklad |
41724 |
401 |
FHH-Chr 7BN/Mcwi |
heart rate |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) |
PhysGen Cardiac data |
heart pumping trait |
female |
49 days-63 days |
10 |
|
247.25 |
beats/min |
10.15 |
32.1 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
Moms and pups used in studies were fed Teklad |
47658 |
461 |
FHH-Chr 7BN/Mcwi |
percent change in left ventricular developed pressure |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) |
PhysGen Cardiac data |
heart left ventricular blood pressure trait |
male |
49 days-63 days |
10 |
post-ischemic value/pre-ischemic value x 100% |
40.61 |
% |
8.64 |
27.32 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
Moms and pups used in studies were fed Teklad |
48608 |
461 |
FHH-Chr 7BN/Mcwi |
methylene blue metabolism-surface area product without auto-oxidation |
controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) |
PhysGen Lung data |
pulmonary blood flow trait |
female |
77 days-91 days |
6 |
|
19.86 |
ml/min/kg |
1.2 |
2.95 |
isolated perfused lung vascular effluent collection |
|
0 |
|
Moms and pups used in studies were fed Teklad |
57877 |
526 |
FHH-Chr 7BN/Mcwi |
body temperature |
controlled air oxygen content (12 %) (for 0.1 hours) |
PhysGen Respiratory data |
body temperature trait |
female |
82 days-99 days |
11 |
|
37.21 |
degrees C |
0.16 |
0.52 |
digital rectal thermometry |
|
0 |
|
Moms and pups used in studies were fed Teklad |
16650 |
381 |
FHH-Chr 7BN/Mcwi |
heart right ventricle weight to left ventricle weight ratio |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Lung data |
heart right ventricle mass |
female |
77 days-91 days |
10 |
|
0.4 |
null |
0.01 |
0.04 |
digital scale post excision weight measurement |
|
0 |
|
Moms and pups used in studies were fed Teklad |
58810 |
526 |
FHH-Chr 7BN/Mcwi |
heart weight to body weight ratio |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Cardiac data |
heart mass |
female |
49 days-63 days |
10 |
|
6.76 |
g/kg |
0.23 |
0.72 |
digital scale post excision weight measurement |
|
0 |
|
Moms and pups used in studies were fed Teklad |
45673 |
461 |
FHH-Chr 7BN/Mcwi |
arterial blood flow rate |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) |
PhysGen Cardiac data |
arterial blood flow trait |
male |
49 days-63 days |
10 |
|
11.56 |
ml/min/g |
0.59 |
1.86 |
isolated perfused heart effluent collection |
|
0 |
|
Moms and pups used in studies were fed Teklad |
46734 |
461 |
FHH-Chr 7BN/Mcwi |
respiration rate |
controlled air oxygen content (12 %) (between 0 and 0.1 hours) |
PhysGen Respiratory data |
respiratory function trait |
male |
82 days-99 days |
8 |
|
122.57 |
breaths/min |
8.44 |
23.87 |
stop flow air displacement plethysmography |
|
0 |
|
Moms and pups used in studies were fed Teklad |
18348 |
381 |
FHH-Chr 7BN/Mcwi |
heart rate |
controlled air oxygen content (12 %) (for 0.1 hours) |
PhysGen Respiratory data |
heart pumping trait |
female |
82 days-99 days |
3 |
|
449.72 |
beats/min |
33.88 |
58.69 |
vascular fluid filled catheter |
|
0 |
|
Moms and pups used in studies were fed Teklad |
17543 |
381 |
FHH-Chr 7BN/Mcwi |
arterial blood flow rate |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) |
PhysGen Cardiac data |
arterial blood flow trait |
female |
49 days-63 days |
10 |
|
13.02 |
ml/min/g |
0.59 |
1.88 |
isolated perfused heart effluent collection |
|
0 |
|
Moms and pups used in studies were fed Teklad |
46729 |
461 |
FHH-Chr 7BN/Mcwi |
percent change in respiration rate |
controlled air oxygen content (12 %) (between 0 and 0.1 hours) |
PhysGen Respiratory data |
respiratory function trait |
female |
82 days-99 days |
11 |
|
136.82 |
% |
15.87 |
52.62 |
stop flow air displacement plethysmography |
|
0 |
|
Moms and pups used in studies were fed Teklad |
54403 |
381 |
FHH-Chr 7BN/Mcwi |
time to peak heart contraction |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) |
PhysGen Cardiac data |
heart pumping trait |
female |
49 days-63 days |
10 |
|
1261.7 |
s |
43.13 |
136.4 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
Moms and pups used in studies were fed Teklad |
50303 |
461 |
FHH-Chr 7BN/Mcwi |
percent change in left ventricular developed pressure |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) |
PhysGen Cardiac data |
heart left ventricular blood pressure trait |
female |
49 days-63 days |
10 |
post-ischemic value/pre-ischemic value x 100% |
46.77 |
% |
4.39 |
13.87 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
Moms and pups used in studies were fed Teklad |
48603 |
461 |
FHH-Chr 7BN/Mcwi |
percent change in tidal volume |
controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) |
PhysGen Respiratory data |
pulmonary ventilation trait |
male |
82 days-99 days |
8 |
|
119.0 |
% |
5.48 |
15.49 |
stop flow air displacement plethysmography |
|
0 |
|
Moms and pups used in studies were fed Teklad |
54067 |
381 |
FHH-Chr 7BN/Mcwi |
tidal volume |
controlled air oxygen content (12 %) (between 0 and 0.1 hours) |
PhysGen Respiratory data |
pulmonary ventilation trait |
male |
82 days-99 days |
9 |
|
0.2 |
ml |
0.04 |
0.12 |
stop flow air displacement plethysmography |
|
0 |
|
Moms and pups used in studies were fed Teklad |
14006 |
381 |
FHH-Chr 7BN/Mcwi |
percent change in tidal volume |
controlled air oxygen content (12 %) (between 0 and 0.1 hours) |
PhysGen Respiratory data |
pulmonary ventilation trait |
male |
82 days-99 days |
8 |
|
115.08 |
% |
6.23 |
17.61 |
stop flow air displacement plethysmography |
|
0 |
|
Moms and pups used in studies were fed Teklad |
53966 |
381 |
FHH-Chr 7BN/Mcwi |
serum total protein level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood total protein amount |
male |
77 days-91 days |
10 |
|
5.28 |
g/dl |
0.12 |
0.37 |
standard blood chemistry panel |
|
0 |
|
Moms and pups used in studies were fed Teklad |
37044 |
401 |
FHH-Chr 7BN/Mcwi |
serum calcium level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood calcium amount |
female |
77 days-91 days |
10 |
|
9.24 |
mg/dl |
0.06 |
0.2 |
standard blood chemistry panel |
|
0 |
|
Moms and pups used in studies were fed Teklad |
36701 |
401 |
FHH-Chr 7BN/Mcwi |
partial pressure of blood oxygen |
controlled air oxygen content (12 %) (for 0.1 hours) |
PhysGen Respiratory data |
blood oxygen amount |
male |
82 days-99 days |
2 |
|
50.9 |
mmHg |
1.95 |
2.76 |
automated blood gas analysis using a Bayer analyzer |
|
0 |
|
Moms and pups used in studies were fed Teklad |
20522 |
381 |
FHH-Chr 7BN/Mcwi |
heart left ventricle infarction weight to total heart left ventricle weight ratio |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) |
PhysGen Cardiac data |
heart left ventricle integrity trait |
male |
49 days-63 days |
10 |
|
6.3 |
% |
1.67 |
5.3 |
digital scale post excision weight measurement |
|
0 |
|
Moms and pups used in studies were fed Teklad |
49779 |
461 |
FHH-Chr 7BN/Mcwi |
time to peak heart contraction |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) |
PhysGen Cardiac data |
heart pumping trait |
male |
49 days-63 days |
10 |
|
1184.9 |
s |
46.01 |
145.49 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
Moms and pups used in studies were fed Teklad |
50308 |
461 |
FHH-Chr 7BN/Mcwi |
serum albumin level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood albumin amount |
female |
77 days-91 days |
10 |
|
3.92 |
g/dl |
0.04 |
0.13 |
standard blood chemistry panel |
|
0 |
|
Moms and pups used in studies were fed Teklad |
42310 |
401 |
FHH-Chr 7BN/Mcwi |
serum chloride level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood chloride amount |
male |
77 days-91 days |
10 |
|
110.0 |
mmol/l |
0.58 |
1.83 |
standard blood chemistry panel |
|
0 |
|
Moms and pups used in studies were fed Teklad |
39199 |
401 |
FHH-Chr 7BN/Mcwi |
red blood cell count |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
erythrocyte quantity |
male |
77 days-91 days |
10 |
|
9.49 |
x 10E6 cells/ul |
0.15 |
0.46 |
automated blood cell counting method |
|
0 |
|
Moms and pups used in studies were fed Teklad |
39319 |
401 |
FHH-Chr 7BN/Mcwi |
mean corpuscular hemoglobin |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood hemoglobin amount |
male |
77 days-91 days |
10 |
|
18.78 |
pg |
0.17 |
0.54 |
automated blood cell counting method |
|
0 |
|
Moms and pups used in studies were fed Teklad |
42627 |
401 |
FHH-Chr 7BN/Mcwi |
dose of methacholine at which pulmonary conductance is half its pretreatment value |
controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) |
PhysGen Lung data |
pulmonary ventilation trait |
female |
77 days-91 days |
10 |
|
1.65 |
mg/kg |
0.45 |
1.42 |
stop flow air displacement plethysmography |
|
0 |
|
Moms and pups used in studies were fed Teklad |
58983 |
526 |
FHH-Chr 7BN/Mcwi |
body weight |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Lung data |
body mass |
male |
77 days-91 days |
10 |
|
206.4 |
g |
11.8 |
37.2 |
whole body digital scale |
|
0 |
|
Moms and pups used in studies were fed Teklad |
59144 |
526 |
FHH-Chr 7BN/Mcwi |
serum alanine aminotransferase activity level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood alanine transaminase amount |
female |
77 days-91 days |
10 |
|
35.8 |
U/l |
2.35 |
7.42 |
standard blood chemistry panel |
|
0 |
|
Moms and pups used in studies were fed Teklad |
40791 |
401 |
FHH-Chr 7BN/Mcwi |
hematocrit |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Lung data |
erythrocyte quantity |
female |
77 days-91 days |
10 |
|
52.25 |
% |
0.56 |
1.78 |
microhematocrit tube assay with visual assessment |
|
0 |
|
Moms and pups used in studies were fed Teklad |
59334 |
526 |
FHH-Chr 7BN/Mcwi |
serum phosphate level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood phosphate amount |
female |
77 days-91 days |
10 |
|
9.74 |
mg/dl |
0.53 |
1.67 |
standard blood chemistry panel |
|
0 |
|
Moms and pups used in studies were fed Teklad |
37671 |
401 |
FHH-Chr 7BN/Mcwi |
blood hemoglobin level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood hemoglobin amount |
male |
77 days-91 days |
10 |
|
17.8 |
g/dl |
0.21 |
0.65 |
automated blood cell counting method |
|
0 |
|
Moms and pups used in studies were fed Teklad |
38050 |
401 |
FHH-Chr 7BN/Mcwi |
plasma anion gap |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
ion homeostasis trait |
male |
77 days-91 days |
10 |
|
20.1 |
mmol/l |
0.38 |
1.2 |
standard blood chemistry panel |
|
0 |
|
Moms and pups used in studies were fed Teklad |
38343 |
401 |
FHH-Chr 7BN/Mcwi |
blood eosinophil count |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
eosinophil quantity |
male |
77 days-91 days |
10 |
|
0.04 |
x 1000 cells/ul |
0.02 |
0.07 |
automated blood cell counting method |
|
0 |
|
Moms and pups used in studies were fed Teklad |
41729 |
401 |
FHH-Chr 7BN/Mcwi |
serum total bilirubin level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood bilirubin amount |
female |
77 days-91 days |
10 |
|
0.1 |
mg/dl |
0.0 |
0.0 |
standard blood chemistry panel |
|
0 |
|
Moms and pups used in studies were fed Teklad |
41945 |
401 |
FHH-Chr 7BN/Mcwi |
fractional change in blood vessel diameter per unit change in intravascular pressure |
controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) |
PhysGen Lung data |
blood vessel distensibility trait |
female |
77 days-91 days |
9 |
|
0.04 |
mmHg-1 |
0.0 |
0.01 |
fluid-filled catheter with pressure transducer in isolated perfused lung |
|
0 |
|
Moms and pups used in studies were fed Teklad |
58566 |
526 |
FHH-Chr 7BN/Mcwi |
heart weight to body weight ratio |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Cardiac data |
heart mass |
male |
49 days-63 days |
10 |
|
6.68 |
g/kg |
0.18 |
0.56 |
digital scale post excision weight measurement |
|
0 |
|
Moms and pups used in studies were fed Teklad |
45681 |
461 |
FHH-Chr 7BN/Mcwi |
left ventricular systolic blood pressure |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) |
PhysGen Cardiac data |
heart left ventricular blood pressure trait |
male |
49 days-63 days |
10 |
|
114.78 |
mmHg |
8.06 |
25.49 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
Moms and pups used in studies were fed Teklad |
45810 |
461 |
FHH-Chr 7BN/Mcwi |
arterial blood flow rate |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) |
PhysGen Cardiac data |
arterial blood flow trait |
male |
49 days-63 days |
10 |
|
4.29 |
ml/min/g |
0.35 |
1.11 |
isolated perfused heart effluent collection |
|
0 |
|
Moms and pups used in studies were fed Teklad |
44799 |
461 |
FHH-Chr 7BN/Mcwi |
percent change in tidal volume |
controlled air oxygen content (12 %) (between 0 and 0.1 hours) |
PhysGen Respiratory data |
pulmonary ventilation trait |
female |
82 days-99 days |
11 |
|
122.03 |
% |
6.03 |
20.0 |
stop flow air displacement plethysmography |
|
0 |
|
Moms and pups used in studies were fed Teklad |
53962 |
381 |
FHH-Chr 7BN/Mcwi |
percent change in ventilation |
controlled air oxygen content (12 %) (between 0 and 0.1 hours) |
PhysGen Respiratory data |
pulmonary ventilation trait |
male |
82 days-99 days |
8 |
%change=VE during 2-3 min hypoxia/control during standard conditions |
141.74 |
% |
7.25 |
20.5 |
stop flow air displacement plethysmography |
|
0 |
|
Moms and pups used in studies were fed Teklad |
13763 |
381 |
FHH-Chr 7BN/Mcwi |
respiration rate |
controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) |
PhysGen Respiratory data |
respiratory function trait |
female |
82 days-99 days |
11 |
|
106.95 |
breaths/min |
8.95 |
29.69 |
stop flow air displacement plethysmography |
|
0 |
|
Moms and pups used in studies were fed Teklad |
14872 |
381 |
FHH-Chr 7BN/Mcwi |
percent change in heart rate |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) |
PhysGen Cardiac data |
heart pumping trait |
female |
49 days-63 days |
10 |
post-ischemic value/pre-ischemic value x 100% |
80.76 |
% |
5.14 |
16.26 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
Moms and pups used in studies were fed Teklad |
48371 |
461 |
FHH-Chr 7BN/Mcwi |
arterial blood flow rate |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) |
PhysGen Cardiac data |
arterial blood flow trait |
female |
49 days-63 days |
10 |
|
5.42 |
ml/min/g |
0.48 |
1.53 |
isolated perfused heart effluent collection |
|
0 |
|
Moms and pups used in studies were fed Teklad |
44794 |
461 |
FHH-Chr 7BN/Mcwi |
blood monocyte count |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
monocyte quantity |
male |
77 days-91 days |
10 |
|
0.29 |
x 1000 cells/ul |
0.07 |
0.21 |
automated blood cell counting method |
|
0 |
|
Moms and pups used in studies were fed Teklad |
39756 |
401 |
FHH-Chr 7BN/Mcwi |
plasma anion gap |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
ion homeostasis trait |
female |
77 days-91 days |
10 |
|
18.1 |
mmol/l |
0.59 |
1.85 |
standard blood chemistry panel |
|
0 |
|
Moms and pups used in studies were fed Teklad |
38338 |
401 |
FHH-Chr 7BN/Mcwi |
left ventricular systolic blood pressure |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) |
PhysGen Cardiac data |
heart left ventricular blood pressure trait |
male |
49 days-63 days |
10 |
|
95.33 |
mmHg |
5.64 |
17.82 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
Moms and pups used in studies were fed Teklad |
49969 |
461 |
FHH-Chr 7BN/Mcwi |
heart contraction pressure |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) |
PhysGen Cardiac data |
heart muscle contractility trait |
male |
49 days-63 days |
10 |
|
35.8 |
mmHg |
3.26 |
10.29 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
Moms and pups used in studies were fed Teklad |
50078 |
461 |
FHH-Chr 7BN/Mcwi |
serum chloride level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood chloride amount |
female |
77 days-91 days |
10 |
|
108.3 |
mmol/l |
0.6 |
1.89 |
standard blood chemistry panel |
|
0 |
|
Moms and pups used in studies were fed Teklad |
39194 |
401 |
FHH-Chr 7BN/Mcwi |
tidal volume |
controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) |
PhysGen Respiratory data |
pulmonary ventilation trait |
male |
82 days-99 days |
9 |
|
0.21 |
ml |
0.04 |
0.11 |
stop flow air displacement plethysmography |
|
0 |
|
Moms and pups used in studies were fed Teklad |
15316 |
381 |
FHH-Chr 7BN/Mcwi |
respiration rate |
controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) |
PhysGen Respiratory data |
respiratory function trait |
male |
82 days-99 days |
8 |
|
108.27 |
breaths/min |
5.42 |
15.34 |
stop flow air displacement plethysmography |
|
0 |
|
Moms and pups used in studies were fed Teklad |
14877 |
381 |
FHH-Chr 7BN/Mcwi |
percent change in tidal volume |
controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) |
PhysGen Respiratory data |
pulmonary ventilation trait |
female |
82 days-99 days |
11 |
|
120.17 |
% |
8.5 |
28.21 |
stop flow air displacement plethysmography |
|
0 |
|
Moms and pups used in studies were fed Teklad |
54063 |
381 |
FHH-Chr 7BN/Mcwi |
partial pressure of blood carbon dioxide (Pco2) |
controlled air oxygen content (12 %) (for 0.1 hours) |
PhysGen Respiratory data |
blood gas amount |
female |
82 days-99 days |
3 |
|
28.28 |
mmHg |
1.37 |
2.38 |
automated blood gas analysis using a Bayer analyzer |
|
0 |
|
Moms and pups used in studies were fed Teklad |
17280 |
381 |
FHH-Chr 7BN/Mcwi |
percent change in respiration rate |
controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) |
PhysGen Respiratory data |
respiratory function trait |
male |
82 days-99 days |
8 |
|
110.9 |
% |
6.17 |
17.46 |
stop flow air displacement plethysmography |
|
0 |
|
Moms and pups used in studies were fed Teklad |
53834 |
381 |
FHH-Chr 7BN/Mcwi |
respiration rate |
controlled air oxygen content (12 %) (between 0 and 0.1 hours) |
PhysGen Respiratory data |
respiratory function trait |
female |
82 days-99 days |
11 |
|
117.68 |
breaths/min |
10.83 |
35.93 |
stop flow air displacement plethysmography |
|
0 |
|
Moms and pups used in studies were fed Teklad |
18343 |
381 |
FHH-Chr 7BN/Mcwi |
serum total cholesterol level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood cholesterol amount |
female |
77 days-91 days |
10 |
|
76.7 |
mg/dl |
2.69 |
8.51 |
standard blood chemistry panel |
|
0 |
|
Moms and pups used in studies were fed Teklad |
37174 |
401 |
FHH-Chr 7BN/Mcwi |
serum total cholesterol level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood cholesterol amount |
male |
77 days-91 days |
10 |
|
79.5 |
mg/dl |
1.78 |
5.64 |
standard blood chemistry panel |
|
0 |
|
Moms and pups used in studies were fed Teklad |
37179 |
401 |
FHH-Chr 7BN/Mcwi |
serum calcium level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood calcium amount |
male |
77 days-91 days |
10 |
|
9.26 |
mg/dl |
0.11 |
0.36 |
standard blood chemistry panel |
|
0 |
|
Moms and pups used in studies were fed Teklad |
36706 |
401 |
FHH-Chr 7BN/Mcwi |
minute ventilation |
controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) |
PhysGen Respiratory data |
pulmonary ventilation trait |
female |
82 days-99 days |
11 |
|
32.87 |
ml/min |
4.5 |
14.94 |
stop flow air displacement plethysmography |
|
0 |
|
Moms and pups used in studies were fed Teklad |
20286 |
381 |
FHH-Chr 7BN/Mcwi |
absolute change in body temperature |
controlled air oxygen content (12 %) (for 0.1 hours) |
PhysGen Respiratory data |
body temperature trait |
female |
82 days-99 days |
11 |
|
-0.02 |
degrees C |
0.19 |
0.64 |
digital rectal thermometry |
|
0 |
|
Moms and pups used in studies were fed Teklad |
20387 |
381 |
FHH-Chr 7BN/Mcwi |
partial pressure of blood oxygen |
controlled air oxygen content (12 %) (for 0.1 hours) |
PhysGen Respiratory data |
blood oxygen amount |
female |
82 days-99 days |
3 |
|
51.7 |
mmHg |
1.25 |
2.17 |
automated blood gas analysis using a Bayer analyzer |
|
0 |
|
Moms and pups used in studies were fed Teklad |
20515 |
381 |
FHH-Chr 7BN/Mcwi |
left ventricular systolic blood pressure |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) |
PhysGen Cardiac data |
heart left ventricular blood pressure trait |
female |
49 days-63 days |
10 |
|
102.23 |
mmHg |
4.37 |
13.81 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
Moms and pups used in studies were fed Teklad |
49964 |
461 |
FHH-Chr 7BN/Mcwi |
blood monocyte count |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
monocyte quantity |
female |
77 days-91 days |
10 |
|
0.21 |
x 1000 cells/ul |
0.05 |
0.16 |
automated blood cell counting method |
|
0 |
|
Moms and pups used in studies were fed Teklad |
39751 |
401 |
FHH-Chr 7BN/Mcwi |
mean corpuscular hemoglobin concentration |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood hemoglobin amount |
female |
77 days-91 days |
10 |
|
31.8 |
g/dl |
0.07 |
0.22 |
automated blood cell counting method |
|
0 |
|
Moms and pups used in studies were fed Teklad |
39854 |
401 |
FHH-Chr 7BN/Mcwi |
mean corpuscular hemoglobin concentration |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood hemoglobin amount |
male |
77 days-91 days |
10 |
|
31.98 |
g/dl |
0.09 |
0.29 |
automated blood cell counting method |
|
0 |
|
Moms and pups used in studies were fed Teklad |
39859 |
401 |
FHH-Chr 7BN/Mcwi |
serum alanine aminotransferase activity level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood alanine transaminase amount |
male |
77 days-91 days |
10 |
|
45.2 |
U/l |
3.59 |
11.34 |
standard blood chemistry panel |
|
0 |
|
Moms and pups used in studies were fed Teklad |
40796 |
401 |
FHH-Chr 7BN/Mcwi |
calculated pulmonary vascular resistance normalized to body weight |
controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) |
PhysGen Lung data |
pulmonary blood flow trait |
female |
77 days-91 days |
9 |
|
0.15 |
mmHg x min x kg x ml-1 |
0.01 |
0.02 |
fluid-filled catheter with pressure transducer in isolated perfused lung |
|
0 |
|
Moms and pups used in studies were fed Teklad |
59624 |
526 |
FHH-Chr 7BN/Mcwi |
heart wet weight |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Cardiac data |
heart mass |
female |
49 days-63 days |
10 |
|
0.89 |
g |
0.03 |
0.1 |
digital scale post excision weight measurement |
|
0 |
|
Moms and pups used in studies were fed Teklad |
45481 |
461 |
FHH-Chr 7BN/Mcwi |
left ventricular diastolic blood pressure |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) |
PhysGen Cardiac data |
heart left ventricular blood pressure trait |
male |
49 days-63 days |
10 |
|
54.1 |
mmHg |
2.82 |
8.9 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
Moms and pups used in studies were fed Teklad |
46498 |
461 |
FHH-Chr 7BN/Mcwi |
left ventricular developed pressure |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) |
PhysGen Cardiac data |
heart left ventricular blood pressure trait |
female |
49 days-63 days |
10 |
|
121.44 |
mmHg |
4.38 |
13.85 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
Moms and pups used in studies were fed Teklad |
48700 |
461 |
FHH-Chr 7BN/Mcwi |
methylene blue metabolism-surface area product after auto-oxidation |
controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) |
PhysGen Lung data |
pulmonary blood flow trait |
female |
77 days-91 days |
6 |
|
16.95 |
ml/min/kg |
0.49 |
1.21 |
isolated perfused lung vascular effluent collection |
|
0 |
|
Moms and pups used in studies were fed Teklad |
57675 |
526 |
FHH-Chr 7BN/Mcwi |
methylene blue metabolism-surface area product after auto-oxidation |
controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) |
PhysGen Lung data |
pulmonary blood flow trait |
male |
77 days-91 days |
10 |
|
14.8 |
ml/min/kg |
0.59 |
1.88 |
isolated perfused lung vascular effluent collection |
|
0 |
|
Moms and pups used in studies were fed Teklad |
57680 |
526 |
FHH-Chr 7BN/Mcwi |
FAPGG metabolism-surface area product |
controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) |
PhysGen Lung data |
pulmonary blood flow trait |
female |
77 days-91 days |
9 |
|
44.4 |
ml/min/kg |
3.69 |
11.08 |
isolated perfused lung vascular effluent collection |
|
0 |
|
Moms and pups used in studies were fed Teklad |
58076 |
526 |
FHH-Chr 7BN/Mcwi |
FAPGG metabolism-surface area product |
controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) |
PhysGen Lung data |
pulmonary blood flow trait |
male |
77 days-91 days |
10 |
|
43.34 |
ml/min/kg |
2.09 |
6.59 |
isolated perfused lung vascular effluent collection |
|
0 |
|
Moms and pups used in studies were fed Teklad |
58081 |
526 |
FHH-Chr 7BN/Mcwi |
fractional change in blood vessel diameter per unit change in intravascular pressure |
controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) |
PhysGen Lung data |
blood vessel distensibility trait |
male |
77 days-91 days |
10 |
|
0.03 |
mmHg-1 |
0.0 |
0.01 |
fluid-filled catheter with pressure transducer in isolated perfused lung |
|
0 |
|
Moms and pups used in studies were fed Teklad |
58571 |
526 |
FHH-Chr 7BN/Mcwi |
percent change in arterial blood flow rate |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) |
PhysGen Cardiac data |
arterial blood flow trait |
female |
49 days-63 days |
10 |
post-ischemic value/pre-ischemic value x 100% |
41.32 |
% |
2.69 |
8.51 |
isolated perfused heart effluent collection |
|
0 |
|
Moms and pups used in studies were fed Teklad |
47153 |
461 |
FHH-Chr 7BN/Mcwi |
left ventricular diastolic blood pressure |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) |
PhysGen Cardiac data |
heart left ventricular blood pressure trait |
male |
49 days-63 days |
10 |
|
4.98 |
mmHg |
0.24 |
0.77 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
Moms and pups used in studies were fed Teklad |
47278 |
461 |
FHH-Chr 7BN/Mcwi |
percent change in heart rate |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) |
PhysGen Cardiac data |
heart pumping trait |
male |
49 days-63 days |
10 |
post-ischemic value/pre-ischemic value x 100% |
82.31 |
% |
3.97 |
12.54 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
Moms and pups used in studies were fed Teklad |
48376 |
461 |
FHH-Chr 7BN/Mcwi |
heart rate |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) |
PhysGen Cardiac data |
heart pumping trait |
female |
49 days-63 days |
10 |
|
199.74 |
beats/min |
14.67 |
46.38 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
Moms and pups used in studies were fed Teklad |
45224 |
461 |
FHH-Chr 7BN/Mcwi |
absolute change in partial pressure of blood oxygen |
controlled air oxygen content (12 %) (for 0.1 hours) |
PhysGen Respiratory data |
blood oxygen amount |
female |
82 days-99 days |
3 |
|
-46.88 |
mmHg |
6.1 |
10.56 |
automated blood gas analysis using a Bayer analyzer |
|
0 |
|
Moms and pups used in studies were fed Teklad |
19503 |
381 |
FHH-Chr 7BN/Mcwi |
heart rate |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) |
PhysGen Cardiac data |
heart pumping trait |
male |
49 days-63 days |
10 |
|
210.62 |
beats/min |
11.76 |
37.17 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
Moms and pups used in studies were fed Teklad |
45229 |
461 |
FHH-Chr 7BN/Mcwi |
heart effluent lactate dehydrogenase activity level normalized to heart weight |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) |
PhysGen Cardiac data |
heart lactate dehydrogenase activity |
female |
49 days-63 days |
10 |
|
0.41 |
IU/g |
0.07 |
0.22 |
isolated perfused heart effluent collection |
|
0 |
|
Moms and pups used in studies were fed Teklad |
47500 |
461 |
FHH-Chr 7BN/Mcwi |
heart effluent lactate dehydrogenase activity level normalized to heart weight |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) |
PhysGen Cardiac data |
heart lactate dehydrogenase activity |
male |
49 days-63 days |
10 |
|
0.29 |
IU/g |
0.04 |
0.14 |
isolated perfused heart effluent collection |
|
0 |
|
Moms and pups used in studies were fed Teklad |
47508 |
461 |
FHH-Chr 7BN/Mcwi |
methylene blue metabolism-surface area product without auto-oxidation |
controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) |
PhysGen Lung data |
pulmonary blood flow trait |
male |
77 days-91 days |
10 |
|
17.01 |
ml/min/kg |
1.19 |
3.76 |
isolated perfused lung vascular effluent collection |
|
0 |
|
Moms and pups used in studies were fed Teklad |
57882 |
526 |