| GH/Omr |
mean arterial blood pressure |
controlled sodium chloride content diet (0.4 %) (for 3 days) then controlled sodium chloride content diet (4 %) (for 23 days) |
Bilusic M, et al., Croat Med J. 2008 Oct;49(5):586-99. |
arterial blood pressure trait |
male |
155.0 days-169.0 days |
20 |
|
serial mean |
147.5 |
mmHg |
2.06 |
9.2 |
radiotelemetry |
left femoral artery |
10 seconds every two minutes for 4 hrs/day every other day for 23 days |
|
|
Dataquest IV system; anesthetized by 1% isoflurane, recover for 3 days |
|
|
11556 |
101 |
| BN.GH-(D6Mit12-D6Rat15)(D18Rat41-D18Mgh4)/Mcwi |
mean arterial blood pressure |
controlled sodium chloride content diet (0.4 %) (for 3 days) then controlled sodium chloride content diet (4 %) (for 23 days) |
Bilusic M, et al., Croat Med J. 2008 Oct;49(5):586-99. |
arterial blood pressure trait |
male |
155.0 days-169.0 days |
16 |
|
serial mean |
99.5 |
mmHg |
2.6 |
10.4 |
radiotelemetry |
left femoral artery |
10 seconds every two minutes for 4 hrs/day every other day for 23 days |
|
|
Dataquest IV system; anesthetized by 1% isoflurane, recover for 3 days |
|
|
11558 |
101 |
| BN/Elh |
mean arterial blood pressure |
controlled sodium chloride content diet (0.4 %) (for 3 days) then controlled sodium chloride content diet (4 %) (for 23 days) |
Bilusic M, et al., Croat Med J. 2008 Oct;49(5):586-99. |
arterial blood pressure trait |
male |
155.0 days-169.0 days |
21 |
|
serial mean |
93.0 |
mmHg |
2.03 |
9.3 |
radiotelemetry |
left femoral artery |
10 seconds every two minutes for 4 hrs/day every other day for 23 days |
|
|
Dataquest IV system; anesthetized by 1% isoflurane, recover for 3 days |
|
|
11561 |
101 |
| BN.GH-(D2Rat22-D2Mgh11)(D6Mit12-D6Rat15)(D18Rat41-D18Mgh4)/Mcwi |
mean arterial blood pressure |
controlled sodium chloride content diet (0.4 %) (for 3 days) then controlled sodium chloride content diet (4 %) (for 23 days) |
Bilusic M, et al., Croat Med J. 2008 Oct;49(5):586-99. |
arterial blood pressure trait |
male |
155.0 days-169.0 days |
16 |
|
serial mean |
93.5 |
mmHg |
2.15 |
8.6 |
radiotelemetry |
left femoral artery |
10 seconds every two minutes for 4 hrs/day every other day for 23 days |
|
|
Dataquest IV system; anesthetized by 1% isoflurane, recover for 3 days |
|
|
11560 |
101 |
| SS.BN-(D13Hmgc1048-D13Hmgc1050)/Mcwi |
diastolic blood pressure |
controlled sodium chloride content diet (0.4 %) (between 23 and 32 days) |
Cowley AW Jr, et al., Physiol Genomics. 2016 Jan;48(1):62-72. doi: 10.1152/physiolgenomics.00097.2015. Epub 2015 Nov 3. |
arterial blood pressure trait |
male |
44.0 days-53.0 days |
11 |
|
serial mean |
89.0 |
mmHg |
2.0 |
6.63 |
intra-aortic thoracic radiotelemetry via carotid cannulation |
|
10800.0 |
|
|
carotid a. to thoracic aorta implant |
strain 26-P |
|
98489 |
2079 |
| SS/Jr |
heart weight to body weight ratio |
controlled sodium chloride content diet (0.3 %) (for 21 days) then controlled sodium chloride content diet (8 %) (for 42 days) |
Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. |
heart mass |
not specified |
84.0 days
| 5 |
|
|
4.18 |
g/kg |
0.3 |
0.68 |
post excision weight measurement |
|
0.0 |
|
|
|
|
|
103145 |
2787 |
| SR/Jr |
body weight |
controlled sodium chloride content diet (0.3 %) (for 21 days) then controlled sodium chloride content diet (8 %) (for 42 days) |
Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. |
body mass |
not specified |
84.0 days
| 5 |
|
|
349.0 |
g |
10.29 |
23.0 |
body weighing method |
|
0.0 |
|
|
|
|
|
103142 |
2787 |
| SR/Jr |
heart weight |
controlled sodium chloride content diet (0.3 %) (for 21 days) then controlled sodium chloride content diet (8 %) (for 42 days) |
Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. |
heart mass |
not specified |
84.0 days
| 5 |
|
|
1.12 |
g |
0.04 |
0.08 |
post excision weight measurement |
|
0.0 |
|
|
|
|
|
103144 |
2787 |
| SS/Jr |
left ventricular end-diastolic blood pressure |
controlled sodium chloride content diet (0.3 %) (for 21 days) then controlled sodium chloride content diet (8 %) (for 42 days) then pentobarbital, sodium (20 mg/kg) |
Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. |
heart left ventricular blood pressure trait |
not specified |
84.0 days
| 5 |
|
|
3.0 |
mmHg |
0.45 |
1.0 |
vascular transducer tipped catheter |
|
0.0 |
|
|
|
|
|
103151 |
2787 |
| SR/Jr |
heart rate |
controlled sodium chloride content diet (0.3 %) (for 21 days) then controlled sodium chloride content diet (8 %) (for 42 days) then pentobarbital (20 mg/kg) |
Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. |
heart pumping trait |
not specified |
84.0 days
| 5 |
|
|
415.0 |
beats/min |
9.39 |
21.0 |
vascular transducer tipped catheter |
|
0.0 |
|
|
|
|
|
103148 |
2787 |
| SR/Jr |
left ventricular end-diastolic blood pressure |
controlled sodium chloride content diet (0.3 %) (for 21 days) then controlled sodium chloride content diet (8 %) (for 42 days) then pentobarbital, sodium (20 mg/kg) |
Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. |
heart left ventricular blood pressure trait |
not specified |
84.0 days
| 5 |
|
|
1.0 |
mmHg |
0.45 |
1.0 |
vascular transducer tipped catheter |
|
0.0 |
|
|
|
|
|
103152 |
2787 |
| SS/Jr |
maximum rate of positive change in left ventricular blood pressure |
controlled sodium chloride content diet (0.3 %) (for 21 days) then controlled sodium chloride content diet (8 %) (for 42 days) then pentobarbital, sodium (20 mg/kg) |
Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. |
heart left ventricular blood pressure trait |
not specified |
84.0 days
| 5 |
LVdP/dtmax |
|
13200.0 |
mmHg/s |
1207.48 |
2700.0 |
vascular transducer tipped catheter |
|
0.0 |
|
|
|
E3 X mmHg/s |
|
103153 |
2787 |
| SS/Jr |
heart rate |
controlled sodium chloride content diet (0.3 %) (for 21 days) then controlled sodium chloride content diet (8 %) (for 42 days) then ambient air (between 0 and 0.1 hours) |
Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. |
heart pumping trait |
not specified |
86.0 days
| 5 |
sampling once per minute |
|
368.0 |
beats/min |
3.13 |
7.0 |
intra-aortic thoracic radiotelemetry |
|
0.0 |
|
|
|
|
|
103155 |
2787 |
| SR/Jr |
mean arterial blood pressure |
controlled sodium chloride content diet (0.3 %) (for 42 days) then controlled sodium chloride content diet (8 %) (for 42 days) then 10% CO2, 20% O2, 70% N2 (between 0 and 0.1 hours) |
Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. |
arterial blood pressure trait |
not specified |
86.0 days
| 5 |
sampling once per minute |
|
109.0 |
mmHg |
0.89 |
2.0 |
intra-aortic thoracic radiotelemetry |
|
0.0 |
|
|
|
|
|
103168 |
2787 |
| SS/Jr |
respiration rate |
controlled sodium chloride content diet (0.3 %) (for 21 days) then controlled sodium chloride content diet (8 %) (for 42 days) then ambient air (between 0 and 0.1 hours) |
Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. |
respiratory function trait |
not specified |
86.0 days
| 5 |
sampling once per minute |
|
123.0 |
breaths/min |
1.34 |
3.0 |
spirometry |
|
0.0 |
|
|
|
|
|
103175 |
2787 |
| SS/Jr |
heart rate |
controlled sodium chloride content diet (0.3 %) (for 21 days) then controlled sodium chloride content diet (8 %) (for 42 days) then atropine (1 mg/kg) (between 0.9 and 1 hours) then 10% CO2, 20% O2, 70% N2 (for 0.4 hours) then ambient air (between 0 and 0.1 hours) |
Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. |
heart pumping trait |
not specified |
86.0 days
| 4 |
sampling once per minute |
|
486.0 |
beats/min |
4.5 |
9.0 |
intra-aortic thoracic radiotelemetry |
|
0.0 |
25 |
min |
|
|
|
103194 |
2787 |
| SS/Jr |
heart rate |
controlled sodium chloride content diet (0.3 %) (for 21 days) then controlled sodium chloride content diet (8 %) (for 42 days) then atropine (1 mg/kg) (between 0.5 and 0.9 hours) then 10% CO2, 20% O2, 70% N2 (between 0 and 0.4 hours) |
Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. |
heart pumping trait |
not specified |
86.0 days
| 4 |
sampling once per minute |
|
428.0 |
beats/min |
6.0 |
12.0 |
intra-aortic thoracic radiotelemetry |
|
0.0 |
25 |
min |
|
|
|
103192 |
2787 |
| SS/Jr |
heart rate |
controlled sodium chloride content diet (0.3 %) (for 21 days) then controlled sodium chloride content diet (8 %) (for 42 days) then atropine (1 mg/kg) (between 0.9 and 1.3 hours) then 10% CO2, 20% O2, 70% N2 (for 0.4 hours) then ambient air (between 0 and 0.4 hours) |
Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. |
heart pumping trait |
not specified |
86.0 days
| 4 |
sampling once per minute |
|
471.0 |
beats/min |
7.5 |
15.0 |
intra-aortic thoracic radiotelemetry |
|
0.0 |
25 |
min |
|
|
|
103196 |
2787 |
| SR/Jr |
mean arterial blood pressure |
controlled sodium chloride content diet (0.3 %) (for 42 days) then controlled sodium chloride content diet (8 %) (for 42 days) then atropine (1 mg/kg) then ambient air (between 0 and 0.1 hours) |
Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. |
arterial blood pressure trait |
not specified |
86.0 days
| 5 |
sampling once per minute |
|
112.0 |
mmHg |
1.34 |
3.0 |
intra-aortic thoracic radiotelemetry |
|
0.0 |
|
|
|
|
|
103199 |
2787 |
| SR/Jr |
mean arterial blood pressure |
controlled sodium chloride content diet (0.3 %) (for 42 days) then controlled sodium chloride content diet (8 %) (for 42 days) then atropine (1 mg/kg) then 10% CO2, 20% O2, 70% N2 (between 0 and 0.1 hours) |
Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. |
arterial blood pressure trait |
not specified |
86.0 days
| 5 |
sampling once per minute |
|
117.0 |
mmHg |
1.34 |
3.0 |
intra-aortic thoracic radiotelemetry |
|
0.0 |
|
|
|
|
|
103201 |
2787 |
| SS/Jr |
mean arterial blood pressure |
controlled sodium chloride content diet (0.3 %) (for 42 days) then controlled sodium chloride content diet (8 %) (for 42 days) then atropine (1 mg/kg) then 10% CO2, 20% O2, 70% N2 (between 0 and 0.4 hours) then ambient air (between 0 and 0.1 hours) |
Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. |
arterial blood pressure trait |
not specified |
86.0 days
| 4 |
sampling once per minute |
|
135.0 |
mmHg |
2.0 |
4.0 |
intra-aortic thoracic radiotelemetry |
|
0.0 |
|
|
|
|
|
103204 |
2787 |
| SR/Jr |
mean arterial blood pressure |
controlled sodium chloride content diet (0.3 %) (for 42 days) then controlled sodium chloride content diet (8 %) (for 42 days) then atropine (1 mg/kg) then 10% CO2, 20% O2, 70% N2 (between 0 and 0.4 hours) then ambient air (between 0 and 0.4 hours) |
Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. |
arterial blood pressure trait |
not specified |
86.0 days
| 5 |
sampling once per minute |
|
114.0 |
mmHg |
2.24 |
5.0 |
intra-aortic thoracic radiotelemetry |
|
0.0 |
|
|
|
|
|
103207 |
2787 |
| SR/JrHsd |
body weight |
controlled sodium chloride content diet (0.4 %) (for 14 days) then bilateral ovariectomy then peanut oil (0.2 ml) (for 14 days) |
Zheng W, et al., Am J Physiol Heart Circ Physiol. 2008 Apr;294(4):H1508-13. doi: 10.1152/ajpheart.01322.2007. Epub 2008 Feb 1. |
body mass |
female |
days
| |
|
|
276.0 |
g |
11.0 |
|
body weighing method |
|
0.0 |
|
|
|
|
|
102185 |
2681 |
| SR/JrHsd |
single kidney wet weight |
controlled sodium chloride content diet (4 %) (for 14 days) then sham surgical control condition then peanut oil (0.2 ml) (for 14 days) |
Zheng W, et al., Am J Physiol Heart Circ Physiol. 2008 Apr;294(4):H1508-13. doi: 10.1152/ajpheart.01322.2007. Epub 2008 Feb 1. |
kidney mass |
female |
days
| |
|
|
1.05 |
g |
0.03 |
|
post excision weight measurement |
|
0.0 |
|
|
|
|
|
102196 |
2681 |
| SS/JrHsd |
single kidney wet weight |
controlled sodium chloride content diet (4 %) (for 14 days) then bilateral ovariectomy then peanut oil (0.2 ml) (for 14 days) |
Zheng W, et al., Am J Physiol Heart Circ Physiol. 2008 Apr;294(4):H1508-13. doi: 10.1152/ajpheart.01322.2007. Epub 2008 Feb 1. |
kidney mass |
female |
days
| |
|
|
1.37 |
g |
0.03 |
|
post excision weight measurement |
|
0.0 |
|
|
|
|
|
102204 |
2681 |
| SR/JrHsd |
mean arterial blood pressure |
controlled sodium chloride content diet (0.4 %) (for 14 days) then bilateral ovariectomy then peanut oil (0.2 ml) (for 14 days) |
Zheng W, et al., Am J Physiol Heart Circ Physiol. 2008 Apr;294(4):H1508-13. doi: 10.1152/ajpheart.01322.2007. Epub 2008 Feb 1. |
arterial blood pressure trait |
female |
days
| |
|
|
125.0 |
mmHg |
2.0 |
|
vascular fluid filled catheter |
|
0.0 |
|
|
|
|
|
102208 |
2681 |
| SR/JrHsd |
glomerular filtration rate to kidney weight ratio |
controlled sodium chloride content diet (0.4 %) (for 14 days) then bilateral ovariectomy then peanut oil (0.2 ml) (for 14 days) |
Zheng W, et al., Am J Physiol Heart Circ Physiol. 2008 Apr;294(4):H1508-13. doi: 10.1152/ajpheart.01322.2007. Epub 2008 Feb 1. |
glomerular filtration trait |
female |
days
| |
|
|
2.49 |
ml/min/g |
0.2 |
|
inulin analysis by liquid phase colorimetry |
|
0.0 |
|
|
|
|
|
102214 |
2681 |
| SS/JrHsd |
glomerular filtration rate to kidney weight ratio |
controlled sodium chloride content diet (0.4 %) (for 14 days) then bilateral ovariectomy then 17 beta-estradiol (10 ug/d) (for 14 days) |
Zheng W, et al., Am J Physiol Heart Circ Physiol. 2008 Apr;294(4):H1508-13. doi: 10.1152/ajpheart.01322.2007. Epub 2008 Feb 1. |
glomerular filtration trait |
female |
days
| |
|
|
1.96 |
ml/min/g |
0.04 |
|
inulin analysis by liquid phase colorimetry |
|
0.0 |
|
|
|
|
|
102218 |
2681 |
| SR/NEisSlc |
body weight |
controlled sodium chloride content diet (8 %) (for 21 days) then 0.9% sodium chloride solution (for 21 days) |
Yoshihara F, et al., Regul Pept. 2005 May 15;128(1):7-13. |
body mass |
male |
77.0 days
| 19 |
|
|
370.0 |
g |
2.52 |
11.0 |
body weighing method |
|
0.0 |
|
|
|
|
|
102453 |
2689 |
| SS/NEisSlc |
body weight |
controlled sodium chloride content diet (0.3 %) (for 42 days) then controlled sodium chloride content diet (8 %) (for 84 days) |
Horinaka S, et al., Int J Cardiol. 2003 Sep;91(1):25-35. |
body mass |
male |
126.0 days
| 10 |
|
|
298.0 |
g |
4.43 |
14.0 |
body weighing method |
|
0.0 |
|
|
|
|
|
102483 |
2690 |
| SS/NEisSlc |
heart left ventricle weight |
controlled sodium chloride content diet (0.3 %) (for 42 days) then controlled sodium chloride content diet (8 %) (for 84 days) |
Horinaka S, et al., Int J Cardiol. 2003 Sep;91(1):25-35. |
heart left ventricle mass |
male |
126.0 days
| 10 |
|
|
1.31 |
g |
0.0 |
0.01 |
post excision weight measurement |
|
0.0 |
|
|
|
|
|
102487 |
2690 |
| SS/NEisSlc |
systolic blood pressure |
controlled sodium chloride content diet (0.3 %) (for 42 days) then controlled sodium chloride content diet (8 %) (for 84 days) |
Horinaka S, et al., Int J Cardiol. 2003 Sep;91(1):25-35. |
arterial blood pressure trait |
male |
126.0 days
| 10 |
undefined |
|
249.0 |
mmHg |
5.06 |
16.0 |
tail cuff plethysmography |
|
0.0 |
|
|
|
|
|
102495 |
2690 |
| SS/NEisSlc |
heart rate |
controlled sodium chloride content diet (0.3 %) (for 42 days) then controlled sodium chloride content diet (8 %) (for 35 days) |
Horinaka S, et al., Int J Cardiol. 2003 Sep;91(1):25-35. |
heart pumping trait |
male |
77.0 days
| 10 |
|
|
518.0 |
beats/min |
3.48 |
11.0 |
tail cuff plethysmography |
|
0.0 |
|
|
|
|
|
102498 |
2690 |
| SR/NEisSlc |
heart rate |
controlled sodium chloride content diet (0.3 %) (for 42 days) then controlled sodium chloride content diet (8 %) (for 35 days) then pentobarbital (20 mg/kg) |
Horinaka S, et al., Int J Cardiol. 2003 Sep;91(1):25-35. |
heart pumping trait |
male |
77.0 days
| 10 |
|
|
383.0 |
beats/min |
6.96 |
22.0 |
tail cuff plethysmography |
|
0.0 |
|
|
|
|
|
102504 |
2690 |
| SS/NEisSlc |
heart rate |
controlled sodium chloride content diet (0.3 %) (for 42 days) then controlled sodium chloride content diet (8 %) (for 84 days) then pentobarbital (20 mg/kg) |
Horinaka S, et al., Int J Cardiol. 2003 Sep;91(1):25-35. |
heart pumping trait |
male |
126.0 days
| 10 |
|
|
326.0 |
beats/min |
13.28 |
42.0 |
tail cuff plethysmography |
|
0.0 |
|
|
|
|
|
102507 |
2690 |
| SR/NEisSlc |
end-systolic volume |
controlled sodium chloride content diet (0.3 %) (for 42 days) then controlled sodium chloride content diet (8 %) (for 35 days) then pentobarbital (20 mg/kg) |
Horinaka S, et al., Int J Cardiol. 2003 Sep;91(1):25-35. |
cardiac output trait |
male |
77.0 days
| 10 |
|
|
0.07 |
ml |
0.02 |
0.06 |
volume pressure recording |
|
0.0 |
|
|
|
|
|
102512 |
2690 |
| SR/NEisSlc |
end-diastolic volume |
controlled sodium chloride content diet (0.3 %) (for 42 days) then controlled sodium chloride content diet (8 %) (for 84 days) then pentobarbital (20 mg/kg) |
Horinaka S, et al., Int J Cardiol. 2003 Sep;91(1):25-35. |
cardiac output trait |
male |
126.0 days
| 10 |
|
|
0.19 |
ml |
0.02 |
0.07 |
volume pressure recording |
|
0.0 |
|
|
|
|
|
102517 |
2690 |
| SS/NEisSlc |
end-diastolic volume |
controlled sodium chloride content diet (0.3 %) (for 42 days) then controlled sodium chloride content diet (8 %) (for 84 days) then pentobarbital (20 mg/kg) |
Horinaka S, et al., Int J Cardiol. 2003 Sep;91(1):25-35. |
cardiac output trait |
male |
126.0 days
| 10 |
|
|
0.24 |
ml |
0.03 |
0.11 |
volume pressure recording |
|
0.0 |
|
|
|
|
|
102519 |
2690 |
| SR/NEisSlc |
heart left ventricle systolic volume-axis intercept |
controlled sodium chloride content diet (0.3 %) (for 42 days) then controlled sodium chloride content diet (8 %) (for 35 days) then pentobarbital (20 mg/kg) |
Horinaka S, et al., Int J Cardiol. 2003 Sep;91(1):25-35. |
cardiac output trait |
male |
77.0 days
| 10 |
|
|
0.17 |
ml |
0.02 |
0.06 |
volume pressure recording |
|
0.0 |
|
|
|
|
|
102524 |
2690 |
| SS/NEisSlc |
heart left ventricle end-systolic elastance |
controlled sodium chloride content diet (0.3 %) (for 42 days) then controlled sodium chloride content diet (8 %) (for 84 days) then pentobarbital (20 mg/kg) |
Horinaka S, et al., Int J Cardiol. 2003 Sep;91(1):25-35. |
heart left ventricular blood pressure trait |
male |
126.0 days
| 10 |
|
|
2092.0 |
mmHg/ml |
237.49 |
751.0 |
volume pressure recording |
|
0.0 |
|
|
|
|
|
102521 |
2690 |
| SS/NEisSlc |
heart left ventricle systolic volume-axis intercept |
controlled sodium chloride content diet (0.3 %) (for 42 days) then controlled sodium chloride content diet (8 %) (for 35 days) then pentobarbital (20 mg/kg) |
Horinaka S, et al., Int J Cardiol. 2003 Sep;91(1):25-35. |
cardiac output trait |
male |
77.0 days
| 10 |
|
|
0.14 |
ml |
0.03 |
0.11 |
volume pressure recording |
|
0.0 |
|
|
|
|
|
102526 |
2690 |
| SR/NEisSlc |
heart left ventricle end-diastolic elastance |
controlled sodium chloride content diet (0.3 %) (for 42 days) then controlled sodium chloride content diet (8 %) (for 35 days) then pentobarbital (20 mg/kg) |
Horinaka S, et al., Int J Cardiol. 2003 Sep;91(1):25-35. |
heart left ventricular blood pressure trait |
male |
77.0 days
| 10 |
|
|
32.0 |
mmHg/ml |
5.69 |
18.0 |
volume pressure recording |
|
0.0 |
|
|
|
|
|
102528 |
2690 |
| SS/NEisSlc |
heart left ventricle diastolic volume-axis intercept |
controlled sodium chloride content diet (0.3 %) (for 42 days) then controlled sodium chloride content diet (8 %) (for 35 days) then pentobarbital (20 mg/kg) |
Horinaka S, et al., Int J Cardiol. 2003 Sep;91(1):25-35. |
cardiac output trait |
male |
77.0 days
| 10 |
|
|
0.01 |
ml |
0.0 |
0.01 |
volume pressure recording |
|
0.0 |
|
|
|
|
|
102534 |
2690 |
| SS/Jr |
body weight |
controlled sodium chloride content diet (8 %) (for 35 days) |
Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. |
body mass |
male |
63.0 days
| 10 |
|
|
201.0 |
g |
20.0 |
63.25 |
body weighing method |
|
0.0 |
|
|
|
|
|
103237 |
2802 |
| SD-Nfe2l2em1Mcwi-/- |
mean arterial blood pressure |
controlled sodium chloride content diet (0.4 %) (between 70 and 84 days) then controlled sodium chloride content diet (4 %) (for 3 days) then angiotensin II (100 ng/kg/min) (for 3 days) |
Priestley JR, et al., Am J Physiol Heart Circ Physiol. 2016 Feb 15;310(4):H478-87. doi: 10.1152/ajpheart.00586.2015. Epub 2015 Dec 4. |
arterial blood pressure trait |
male |
62.0 days-76.0 days |
5 |
|
|
97.0 |
mmHg |
2.9 |
6.48 |
vascular fluid filled catheter |
|
0.0 |
|
|
|
|
|
100742 |
2520 |
| SD-Nfe2l2em1Mcwi-/- |
resting tone of middle cerebral artery |
controlled sodium chloride content diet (0.4 %) (between 70 and 84 days) then controlled sodium chloride content diet (4 %) (for 3 days) then 0.9% sodium chloride solution (for 3 days) |
Priestley JR, et al., Am J Physiol Heart Circ Physiol. 2016 Feb 15;310(4):H478-87. doi: 10.1152/ajpheart.00586.2015. Epub 2015 Dec 4. |
cerebral artery size trait |
male |
62.0 days-76.0 days |
4 |
[(Dmax - Drest) /Dmax] x 100 |
|
37.4 |
% |
6.53 |
13.06 |
isolated body part method |
|
0.0 |
|
|
|
tone |
|
100758 |
2520 |
| SR/JrHsd |
adrenal angiotensin II type 1 receptor density |
controlled sodium chloride content diet (0.4 %) (for 14 days) then bilateral ovariectomy then peanut oil (0.2 ml) (for 14 days) |
Zheng W, et al., Am J Physiol Heart Circ Physiol. 2008 Apr;294(4):H1508-13. doi: 10.1152/ajpheart.01322.2007. Epub 2008 Feb 1. |
adrenal gland molecular composition trait |
female |
days
| |
|
|
204.0 |
fmol/mg |
38.0 |
|
radioimmunoassay |
|
0.0 |
|
|
|
|
|
102225 |
2681 |
| SS/JrHsd |
adrenal angiotensin II type 1 receptor density |
controlled sodium chloride content diet (0.4 %) (for 14 days) then bilateral ovariectomy then peanut oil (0.2 ml) (for 14 days) |
Zheng W, et al., Am J Physiol Heart Circ Physiol. 2008 Apr;294(4):H1508-13. doi: 10.1152/ajpheart.01322.2007. Epub 2008 Feb 1. |
adrenal gland molecular composition trait |
female |
days
| |
|
|
117.0 |
fmol/mg |
7.3 |
|
radioimmunoassay |
|
0.0 |
|
|
|
|
|
102229 |
2681 |
| SS/JrHsd |
adrenal angiotensin II type 1 receptor density |
controlled sodium chloride content diet (4 %) (for 14 days) then bilateral ovariectomy then 17 beta-estradiol (10 ug/d) (for 14 days) |
Zheng W, et al., Am J Physiol Heart Circ Physiol. 2008 Apr;294(4):H1508-13. doi: 10.1152/ajpheart.01322.2007. Epub 2008 Feb 1. |
adrenal gland molecular composition trait |
female |
days
| |
|
|
90.2 |
fmol/mg |
9.9 |
|
radioimmunoassay |
|
0.0 |
|
|
|
|
|
102232 |
2681 |
| SS.BN-(D13Mit5-D13Rat32)/Mcwi |
diastolic blood pressure |
controlled sodium chloride content diet (0.4 %) (between 46 and 50.8 days) then controlled sodium chloride content diet (8 %) (for 13.4 days) |
Cowley AW, et al., Physiol Genomics. 2014 Jun 1;46(11):398-410. doi: 10.1152/physiolgenomics.00179.2013. Epub 2014 Apr 8. |
arterial blood pressure trait |
male |
60.0 days-67.0 days |
14 |
|
serial mean |
173.0 |
mmHg |
16.0 |
59.87 |
intra-aortic thoracic radiotelemetry via carotid cannulation |
|
10800.0 |
|
|
intra-carotid radiotelemetry |
strain 26-H |
|
98589 |
2098 |
| SD-Nfe2l2em1Mcwi+/+ |
body weight |
controlled sodium chloride content diet (0.4 %) (between 70 and 84 days) then controlled sodium chloride content diet (4 %) (for 3 days) then angiotensin II (100 ng/kg/min) (for 3 days) |
Priestley JR, et al., Am J Physiol Heart Circ Physiol. 2016 Feb 15;310(4):H478-87. doi: 10.1152/ajpheart.00586.2015. Epub 2015 Dec 4. |
body mass |
male |
62.0 days-76.0 days |
6 |
|
|
291.0 |
g |
11.6 |
28.41 |
body weighing method |
|
0.0 |
|
|
|
|
|
100735 |
2520 |
| LEW/Mol |
kidney weight |
controlled sodium chloride content diet (8 %) (for 56 days) |
Kreutz R, etal., J Hypertens. 2000 Jun;18(6):777-82. doi: 10.1097/00004872-200018060-00017. |
kidney mass |
male |
104.0 days
| 8 |
|
|
1.24 |
g |
0.02 |
0.06 |
post excision weight measurement |
kidney |
0.0 |
|
|
|
|
|
109007 |
3134 |
| MWF/Fub |
kidney weight |
controlled sodium chloride content diet (8 %) (for 56 days) |
Kreutz R, etal., J Hypertens. 2000 Jun;18(6):777-82. doi: 10.1097/00004872-200018060-00017. |
kidney mass |
female |
104.0 days
| 8 |
|
|
0.69 |
g |
0.01 |
0.03 |
post excision weight measurement |
kidney |
0.0 |
|
|
|
|
|
109010 |
3134 |
| SR/Jr |
bumetanide-sensitive red blood cell K+ import rate |
controlled sodium chloride content diet (8 %) (for 35 days) |
Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. |
erythrocyte ion transport trait |
male |
63.0 days
| 13 |
|
|
698.0 |
umol/l/h |
73.0 |
263.21 |
Na-K-Cl cotransport activity assay |
|
0.0 |
|
|
|
|
|
111050 |
2802 |
| LEW/Mol |
body weight |
controlled sodium chloride content diet (8 %) (for 56 days) |
Kreutz R, etal., J Hypertens. 2000 Jun;18(6):777-82. doi: 10.1097/00004872-200018060-00017. |
body mass |
male |
104.0 days
| 8 |
|
|
287.0 |
g |
3.6 |
10.18 |
body weighing method |
|
0.0 |
|
|
|
|
|
108999 |
3134 |
| SS/JrHsdMcwi |
mean arterial blood pressure |
controlled sodium chloride content diet (0.4 %) (for 70 days) then controlled sodium chloride content diet (8 %) (for 21 days) |
Hoffman MJ, et al., Hypertension. 2013 Sep;62(3):557-63. doi: 10.1161/HYPERTENSIONAHA.113.01708. Epub 2013 Jul 1. |
arterial blood pressure trait |
female |
91.0 days
| 13 |
|
serial mean |
174.0 |
mmHg |
5.0 |
18.03 |
intra-aortic abdominal radiotelemetry via femoral cannulation |
|
10800.0 |
|
|
|
|
|
98700 |
2141 |
| LN/MavRrrcAek |
mean arterial blood pressure |
standard rat chow (for 98 days) then controlled sodium chloride content diet (4 %) (for 21 days) |
Wang J, et al., Circ Cardiovasc Genet. 2015 Apr;8(2):316-26. doi: 10.1161/CIRCGENETICS.114.000520. Epub 2015 Jan 8. |
arterial blood pressure trait |
male |
119.0 days
| 14 |
mean of 15 sec every 5 min for 72 hours |
serial mean |
99.9 |
mmHg |
1.2 |
4.49 |
intra-aortic abdominal radiotelemetry via femoral cannulation |
|
0.0 |
|
|
|
|
|
102608 |
3014 |
| LN/MavRrrcAek |
diastolic blood pressure |
standard rat chow (for 98 days) then controlled sodium chloride content diet (4 %) (for 21 days) |
Wang J, et al., Circ Cardiovasc Genet. 2015 Apr;8(2):316-26. doi: 10.1161/CIRCGENETICS.114.000520. Epub 2015 Jan 8. |
arterial blood pressure trait |
male |
119.0 days
| 14 |
mean of 15 sec every 5 min for 72 hours |
serial mean |
86.1 |
mmHg |
1.1 |
4.12 |
intra-aortic abdominal radiotelemetry via femoral cannulation |
|
0.0 |
|
|
|
|
|
102612 |
3014 |
| LH/MavRrrcAek |
body weight area under curve (AUC) |
standard rat chow (for 98 days) then controlled sodium chloride content diet (4 %) (for 21 days) |
Wang J, et al., Circ Cardiovasc Genet. 2015 Apr;8(2):316-26. doi: 10.1161/CIRCGENETICS.114.000520. Epub 2015 Jan 8. |
body mass |
male |
21.0 days-126.0 days |
|
body weight X week = growth AUC |
|
4.1351184E7 |
g x min |
396144.0 |
|
body weighing method |
|
0.0 |
|
|
|
growth auc |
|
102617 |
3014 |
| LH/MavRrrcAek |
plasma glucose level |
standard rat chow (for 98 days) then controlled sodium chloride content diet (4 %) (for 14 days) |
Wang J, et al., Circ Cardiovasc Genet. 2015 Apr;8(2):316-26. doi: 10.1161/CIRCGENETICS.114.000520. Epub 2015 Jan 8. |
blood glucose amount |
male |
112.0 days
| 9 |
|
|
141.9 |
mg/dl |
8.1 |
24.3 |
plasma glucose analysis |
|
0.0 |
|
|
|
|
|
102623 |
3014 |
| SS-Mthfrem1Mcwi-/+ |
mean arterial blood pressure |
controlled sodium chloride content diet (0.4 %) (between 56 and 63 days) then controlled sodium chloride content diet (4 %) (for 10 days) |
Flister MJ, et al., Genome Res. 2013 Dec;23(12):1996-2002. doi: 10.1101/gr.160283.113. Epub 2013 Sep 4. |
arterial blood pressure trait |
male |
58.0 days-67.0 days |
|
|
serial mean |
130.0 |
mmHg |
4.0 |
|
intra-aortic abdominal radiotelemetry |
|
32400.0 |
|
|
|
|
|
98401 |
2059 |
| SR/Jr |
heart weight to body weight ratio |
controlled sodium chloride content diet (0.3 %) (for 35 days) |
Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. |
heart mass |
male |
63.0 days
| 16 |
|
|
2.53 |
g/kg |
0.02 |
0.08 |
post excision weight measurement |
|
0.0 |
|
|
|
|
|
103238 |
2802 |
| SS/Jr |
plasma triglyceride level |
controlled sodium chloride content diet (0.3 %) (for 35 days) |
Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. |
blood triglyceride amount |
male |
63.0 days
| 15 |
|
|
1.2 |
mmol/l |
0.16 |
0.62 |
plasma triglyceride analysis |
|
0.0 |
|
|
|
|
|
103260 |
2802 |
| SS/Jr |
hematocrit |
controlled sodium chloride content diet (8 %) (for 35 days) |
Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. |
erythrocyte quantity |
male |
63.0 days
| 10 |
|
|
47.0 |
% |
2.2 |
6.96 |
hematocrit analysis |
|
0.0 |
|
|
|
|
|
103269 |
2802 |
| SR/Jr |
red blood cell sodium level |
controlled sodium chloride content diet (0.3 %) (for 35 days) |
Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. |
erythrocyte sodium amount |
male |
63.0 days
| 16 |
|
|
3.38 |
mmol/l |
0.05 |
0.2 |
ex vivo blood analysis |
|
0.0 |
|
|
|
|
|
103274 |
2802 |
| SS-Renem1Mcwi-/- |
serum alanine aminotransferase activity level |
controlled sodium chloride content diet (0.4 %) (for 42 days) |
Moreno C, et al., Hypertension. 2011 Mar;57(3):614-9. doi: 10.1161/HYPERTENSIONAHA.110.163840. Epub 2011 Jan 17. |
blood alanine transaminase amount |
male |
63.0 days
| 8 |
|
|
53.63 |
U/l |
5.74 |
16.24 |
automated serum analysis |
|
0.0 |
|
|
|
|
|
98357 |
2038 |
| SS-Renem1Mcwi-/- |
heart rate |
controlled sodium chloride content diet (0.4 %) (between 66 and 69 days) |
Moreno C, et al., Hypertension. 2011 Mar;57(3):614-9. doi: 10.1161/HYPERTENSIONAHA.110.163840. Epub 2011 Jan 17. |
heart pumping trait |
male |
66.0 days-69.0 days |
8 |
|
serial mean |
402.94 |
beats/min |
4.46 |
12.61 |
intra-aortic abdominal radiotelemetry |
|
32400.0 |
|
|
|
|
|
98393 |
2038 |
| SS.BN-(D13Hmgc354-D13Rat32)/Mcwi |
mean arterial blood pressure |
controlled sodium chloride content diet (0.4 %) (between 46 and 50.8 days) then controlled sodium chloride content diet (8 %) (for 13.4 days) |
Cowley AW, et al., Physiol Genomics. 2014 Jun 1;46(11):398-410. doi: 10.1152/physiolgenomics.00179.2013. Epub 2014 Apr 8. |
arterial blood pressure trait |
male |
60.0 days-67.0 days |
15 |
|
serial mean |
134.0 |
mmHg |
4.0 |
15.49 |
intra-aortic thoracic radiotelemetry via carotid cannulation |
|
10800.0 |
|
|
intra-carotid radiotelemetry |
strain 26-J |
|
98562 |
2098 |
| SS-Nppbem2Mcwi+/+ |
heart rate |
controlled sodium chloride content diet (for 21 days) |
Holditch SJ, et al., Hypertension. 2015 Jul;66(1):199-210. doi: 10.1161/HYPERTENSIONAHA.115.05610. Epub 2015 May 11. |
heart pumping trait |
male |
98.0 days
| 4 |
|
|
420.0 |
beats/min |
7.0 |
14.0 |
echocardiography |
|
0.0 |
|
|
|
|
|
99728 |
2319 |
| SS |
plasma urotensin II level |
controlled sodium chloride content diet (8 %) (for 42 days) |
Wu F, et al., Int J Hypertens. 2016;2016:9146870. doi: 10.1155/2016/9146870. Epub 2016 Dec 19. |
blood urotensin II amount |
male |
91.0 days
| 8 |
|
|
52.0 |
pg/ml |
4.38 |
12.4 |
radioimmunoassay |
|
0.0 |
|
|
|
|
|
102276 |
2683 |
| SR/Hsd |
urine urotensin II level to urine creatinine level ratio |
controlled sodium chloride content diet (8 %) (for 28 days) |
Wu F, et al., Int J Hypertens. 2016;2016:9146870. doi: 10.1155/2016/9146870. Epub 2016 Dec 19. |
urine urotensin II amount |
male |
77.0 days
| 8 |
|
|
181.3 |
ng/g |
29.66 |
83.9 |
radioimmunoassay |
|
0.0 |
|
|
|
|
|
102279 |
2683 |
| SR/Hsd |
urine sodium level |
controlled sodium chloride content diet (8 %) (for 28 days) |
Wu F, et al., Int J Hypertens. 2016;2016:9146870. doi: 10.1155/2016/9146870. Epub 2016 Dec 19. |
urine sodium amount |
male |
77.0 days
| 8 |
|
|
3.8 |
mmol/l |
0.21 |
0.6 |
urine sodium analysis |
|
0.0 |
|
|
|
|
|
102283 |
2683 |
| SR/NEisSlc |
body weight |
controlled sodium chloride content diet (8 %) (for 21 days) |
Yoshihara F, et al., Regul Pept. 2005 May 15;128(1):7-13. |
body mass |
male |
77.0 days
| 7 |
|
|
371.0 |
g |
4.54 |
12.0 |
body weighing method |
|
0.0 |
|
|
|
|
|
102409 |
2689 |
| SR/NEisSlc |
single kidney wet weight to body weight ratio |
controlled sodium chloride content diet (8 %) (for 14 days) |
Yoshihara F, et al., Regul Pept. 2005 May 15;128(1):7-13. |
kidney mass |
male |
70.0 days
| 8 |
|
|
4.09 |
g/kg |
0.05 |
0.13 |
post excision weight measurement |
|
0.0 |
|
|
|
|
|
102425 |
2689 |
| SR/NEisSlc |
single kidney wet weight to body weight ratio |
controlled sodium chloride content diet (8 %) (for 21 days) |
Yoshihara F, et al., Regul Pept. 2005 May 15;128(1):7-13. |
kidney mass |
male |
77.0 days
| 7 |
|
|
3.67 |
g/kg |
0.05 |
0.13 |
post excision weight measurement |
|
0.0 |
|
|
|
|
|
102427 |
2689 |
| SR/NEisSlc |
urine sodium excretion rate |
controlled sodium chloride content diet (8 %) (for 14 days) |
Yoshihara F, et al., Regul Pept. 2005 May 15;128(1):7-13. |
urine sodium amount |
male |
70.0 days
| 8 |
|
|
1.9 |
mEq/d |
0.21 |
0.6 |
automated urine sodium analysis |
|
0.0 |
|
|
|
|
|
102437 |
2689 |
| SR/NEisSlc |
kidney medullary adrenomedullin level |
controlled sodium chloride content diet (8 %) (for 7 days) |
Yoshihara F, et al., Regul Pept. 2005 May 15;128(1):7-13. |
kidney adrenomedullin amount |
male |
63.0 days
| 7 |
|
|
0.31 |
fmol/mg |
0.02 |
0.06 |
radioimmunoassay |
|
0.0 |
|
|
|
|
|
102447 |
2689 |
| SS/NEisSlc |
urine total protein excretion rate to body weight ratio |
controlled sodium chloride content diet (8 %) (for 7 days) then 0.9% sodium chloride solution (for 7 days) |
Yoshihara F, et al., Regul Pept. 2005 May 15;128(1):7-13. |
total urine protein amount |
male |
63.0 days
| 14 |
|
|
5.2 |
mg/d/100 g |
0.45 |
1.7 |
urine protein analysis |
|
0.0 |
|
|
|
|
|
102472 |
2689 |
| SR/NEisSlc |
urine total protein excretion rate to body weight ratio |
controlled sodium chloride content diet (8 %) (for 21 days) then 0.9% sodium chloride solution (for 21 days) |
Yoshihara F, et al., Regul Pept. 2005 May 15;128(1):7-13. |
total urine protein amount |
male |
77.0 days
| 19 |
|
|
3.4 |
mg/d/100 g |
0.21 |
0.9 |
urine protein analysis |
|
0.0 |
|
|
|
|
|
102477 |
2689 |
| SS/JrHsdMcwi |
renal afferent arteriole diameter |
controlled sodium chloride content diet (1 %) (between 70 and 91 days) then controlled ex vivo artery perfusion pressure (60 mmHg) (for 0.1 hours) |
Miller B, et al., J Clin Invest. 2016 Jul 1;126(7):2533-46. doi: 10.1172/JCI75079. Epub 2016 Jun 6. |
kidney arteriole morphology trait |
not specified |
91.0 days-133.0 days |
9 |
|
|
19.8 |
um |
0.9 |
2.7 |
ex vivo videomicroscopy |
renal afferent arteriole |
120.0 |
|
|
ex vivo videomicroscopy (MMO:0000319) |
renal afferent arteriole diameter () |
renal arteriole morphology trait |
106494 |
3030 |
| SS-Chr 2BN/Mcwi |
renal afferent arteriole diameter |
controlled sodium chloride content diet (1 %) (between 70 and 91 days) then controlled ex vivo artery perfusion pressure (60 mmHg) (for 0.1 hours) |
Miller B, et al., J Clin Invest. 2016 Jul 1;126(7):2533-46. doi: 10.1172/JCI75079. Epub 2016 Jun 6. |
kidney arteriole morphology trait |
not specified |
91.0 days-133.0 days |
8 |
|
|
21.1 |
um |
0.9 |
2.55 |
ex vivo videomicroscopy |
renal afferent arteriole |
120.0 |
|
|
ex vivo videomicroscopy (MMO:0000319) |
renal afferent arteriole diameter (CMO:0003725) |
renal arteriole morphology trait |
106495 |
3030 |
| SS/JrHsdMcwi |
renal afferent arteriole diameter |
controlled sodium chloride content diet (1 %) (between 70 and 91 days) then controlled ex vivo artery perfusion pressure (60 mmHg) (for 0.1 hours) |
Miller B, et al., J Clin Invest. 2016 Jul 1;126(7):2533-46. doi: 10.1172/JCI75079. Epub 2016 Jun 6. |
kidney arteriole morphology trait |
not specified |
91.0 days-133.0 days |
10 |
|
|
24.6 |
um |
0.8 |
2.53 |
ex vivo videomicroscopy |
renal afferent arteriole |
120.0 |
|
|
ex vivo videomicroscopy (MMO:0000319) |
renal afferent arteriole diameter (CMO:0003725) |
renal arteriole morphology trait |
106504 |
3030 |
| SS-Sh2b3em1Mcwi-/- |
spleen weight |
controlled sodium chloride content diet (0.4 %) (for 42 days) |
Rudemiller NP, et al., Hypertension. 2015 May;65(5):1111-7. doi: 10.1161/HYPERTENSIONAHA.114.04736. Epub 2015 Mar 16. |
spleen mass |
not specified |
63.0 days
| 4 |
|
|
2.4 |
g |
0.2 |
0.4 |
post excision weight measurement |
|
0.0 |
|
|
|
n=4-7 |
|
106509 |
3031 |
| SS/JrHsdMcwi |
blood B lymphocyte count |
controlled sodium chloride content diet (0.4 %) (for 42 days) |
Rudemiller NP, et al., Hypertension. 2015 May;65(5):1111-7. doi: 10.1161/HYPERTENSIONAHA.114.04736. Epub 2015 Mar 16. |
B cell quantity |
not specified |
63.0 days
| 4 |
|
|
1.0 |
x 10E6 cells/ml |
0.2 |
0.4 |
flow cytometry method |
|
0.0 |
|
|
|
n=4-7 |
|
106514 |
3031 |
| SS/JrHsdMcwi |
mean arterial blood pressure |
controlled sodium chloride content diet (0.4 %) (for 70 days) |
Rudemiller NP, et al., Hypertension. 2015 May;65(5):1111-7. doi: 10.1161/HYPERTENSIONAHA.114.04736. Epub 2015 Mar 16. |
arterial blood pressure trait |
not specified |
70.0 days
| 6 |
15sec/min for 3 hrs/day for 7days |
|
127.5 |
mmHg |
1.5 |
3.67 |
vascular fluid filled catheter |
|
0.0 |
|
|
|
n=6-8 |
|
106520 |
3031 |
| SBH/Ygl |
systolic blood pressure |
controlled sodium chloride content diet (0.65 %) (for 98 days) |
Landau D, et al., J Endocrinol. 2008 Apr;197(1):75-83. doi: 10.1677/JOE-08-0040. |
arterial blood pressure trait |
male |
98.0 days
| 7 |
|
|
139.0 |
mmHg |
1.0 |
2.65 |
tail cuff plethysmography |
|
0.0 |
|
|
|
|
|
106696 |
3038 |
| SBH/Ygl |
systolic blood pressure |
controlled sodium chloride content diet (8 %) (for 42 days) |
Landau D, et al., J Endocrinol. 2008 Apr;197(1):75-83. doi: 10.1677/JOE-08-0040. |
arterial blood pressure trait |
male |
98.0 days
| 7 |
|
|
181.0 |
mmHg |
2.0 |
5.29 |
tail cuff plethysmography |
|
0.0 |
|
|
|
|
|
106697 |
3038 |
| SBH/Ygl |
body weight |
controlled sodium chloride content diet (0.65 %) (for 98 days) |
Landau D, et al., J Endocrinol. 2008 Apr;197(1):75-83. doi: 10.1677/JOE-08-0040. |
body mass |
male |
98.0 days
| 7 |
|
|
295.0 |
g |
10.0 |
26.46 |
body weighing method |
|
0.0 |
|
|
|
|
|
106700 |
3038 |
| SBH/Ygl |
body weight |
controlled sodium chloride content diet (0.65 %) (for 98 days) then streptozotocin (60 mg/kg) then insulin (10 ul) (for 42 days) |
Landau D, et al., J Endocrinol. 2008 Apr;197(1):75-83. doi: 10.1677/JOE-08-0040. |
body mass |
male |
98.0 days
| 7 |
|
|
223.0 |
g |
15.0 |
39.69 |
body weighing method |
|
0.0 |
|
|
|
|
|
106702 |
3038 |
| SBH/Ygl |
heart weight |
controlled sodium chloride content diet (8 %) (for 42 days) |
Landau D, et al., J Endocrinol. 2008 Apr;197(1):75-83. doi: 10.1677/JOE-08-0040. |
heart mass |
male |
98.0 days
| 7 |
|
|
1.23 |
g |
0.04 |
0.11 |
post excision weight measurement |
|
0.0 |
|
|
|
|
|
106709 |
3038 |
| SS/HsdMcwiCrl |
heart rate |
controlled sodium chloride content diet (0.1 %) (between 28 and 42 days) |
Gabor A and Leenen FH, Brain Res. 2012 Apr 4;1447:28-37. doi: 10.1016/j.brainres.2012.01.060. Epub 2012 Feb 1. |
heart pumping trait |
male |
77.0 days-98.0 days |
4 |
|
|
444.0 |
beats/min |
7.0 |
14.0 |
vascular fluid filled catheter |
femoral artery |
600.0 |
|
|
|
|
|
106774 |
2685 |
| SBH/Ygl |
heart left ventricle end-systolic diameter to body weight ratio |
controlled sodium chloride content diet (0.65 %) (for 98 days) then streptozotocin (60 mg/kg) then insulin (10 ul) (for 42 days) |
Landau D, et al., J Endocrinol. 2008 Apr;197(1):75-83. doi: 10.1677/JOE-08-0040. |
heart left ventricle end-systolic diameter |
male |
98.0 days
| 7 |
|
|
0.99 |
mm/kg |
0.1 |
0.26 |
transthoracic echocardiography |
|
0.0 |
|
|
|
|
|
106722 |
3038 |
| SBH/Ygl |
heart left ventricle end-systolic diameter to body weight ratio |
controlled sodium chloride content diet (8 %) (for 42 days) then streptozotocin (60 mg/kg) then insulin (10 ul) (for 42 days) |
Landau D, et al., J Endocrinol. 2008 Apr;197(1):75-83. doi: 10.1677/JOE-08-0040. |
heart left ventricle end-systolic diameter |
male |
98.0 days
| 7 |
|
|
0.95 |
mm/kg |
0.09 |
0.24 |
transthoracic echocardiography |
|
0.0 |
|
|
|
|
|
106723 |
3038 |
| SS/Jr |
minimum rate of positive change in left ventricular blood pressure |
controlled sodium chloride content diet (0.3 %) (for 21 days) then controlled sodium chloride content diet (8 %) (for 42 days) then pentobarbital, sodium (20 mg/kg) |
Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. |
heart left ventricular blood pressure trait |
not specified |
84.0 days
| 5 |
LVdP/dtmin |
|
7.6 |
10E3 mmHg/s |
4.47 |
1.3 |
vascular transducer tipped catheter |
|
0.0 |
|
|
|
minimum rate of positive change in left ventricular blood pressure |
|
106817 |
2787 |
| SS/HsdMcwiCrl |
mean arterial blood pressure |
controlled sodium chloride content diet (8 %) (between 28 and 42 days) |
Gabor A and Leenen FH, Brain Res. 2012 Apr 4;1447:28-37. doi: 10.1016/j.brainres.2012.01.060. Epub 2012 Feb 1. |
arterial blood pressure trait |
male |
77.0 days-98.0 days |
4 |
MAP=.33(SP-DP) + DP |
|
153.0 |
mmHg |
8.0 |
16.0 |
vascular fluid filled catheter |
femoral artery |
600.0 |
|
|
|
|
|
106758 |
2685 |
| SS/HsdMcwiCrl |
mean arterial blood pressure |
controlled sodium chloride content diet (8 %) (between 28 and 42 days) then candesartan (0.5 ug/min) (for 0.2 hours) then kynurenate (0.14 ug/min) (for 0.2 hours) |
Gabor A and Leenen FH, Brain Res. 2012 Apr 4;1447:28-37. doi: 10.1016/j.brainres.2012.01.060. Epub 2012 Feb 1. |
arterial blood pressure trait |
male |
77.0 days-98.0 days |
5 |
MAP=.33(SP-DP) + DP |
|
135.0 |
mmHg |
4.0 |
8.94 |
vascular fluid filled catheter |
femoral artery |
600.0 |
|
|
|
|
|
106766 |
2685 |
| SS-Chr 13BN/McwiCrl |
heart rate |
controlled sodium chloride content diet (8 %) (between 28 and 42 days) |
Gabor A and Leenen FH, Brain Res. 2012 Apr 4;1447:28-37. doi: 10.1016/j.brainres.2012.01.060. Epub 2012 Feb 1. |
heart pumping trait |
male |
77.0 days-98.0 days |
5 |
|
|
421.0 |
beats/min |
10.0 |
22.36 |
vascular fluid filled catheter |
femoral artery |
600.0 |
|
|
|
|
|
106773 |
2685 |
| BN.GH-(D2Rat22-D2Mgh11)(D6Mit12-D6Rat15)/Mcwi |
mean arterial blood pressure |
controlled sodium chloride content diet (0.4 %) (for 3 days) then controlled sodium chloride content diet (4 %) (for 23 days) |
Bilusic M, et al., Croat Med J. 2008 Oct;49(5):586-99. |
arterial blood pressure trait |
male |
155.0 days-169.0 days |
16 |
|
serial mean |
98.1 |
mmHg |
1.98 |
7.9 |
radiotelemetry |
left femoral artery |
10 seconds every two minutes for 4 hrs/day every other day for 23 days |
|
|
Dataquest IV system; anesthetized by 1% isoflurane, recover for 3 days |
|
|
11557 |
101 |
| SS/Jr |
heart rate |
controlled sodium chloride content diet (0.3 %) (for 21 days) then controlled sodium chloride content diet (8 %) (for 42 days) then pentobarbital (20 mg/kg) |
Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. |
heart pumping trait |
not specified |
84.0 days
| 5 |
|
|
411.0 |
beats/min |
19.68 |
44.0 |
vascular transducer tipped catheter |
|
0.0 |
|
|
|
|
|
103147 |
2787 |
| SR/Jr |
heart rate |
controlled sodium chloride content diet (0.3 %) (for 21 days) then controlled sodium chloride content diet (8 %) (for 42 days) then 10% CO2, 20% O2, 70% N2 (between 0 and 0.1 hours) |
Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. |
heart pumping trait |
not specified |
86.0 days
| 5 |
sampling once per minute |
|
314.0 |
beats/min |
5.37 |
12.0 |
intra-aortic thoracic radiotelemetry |
|
0.0 |
|
|
|
|
|
103158 |
2787 |
| SR/Jr |
heart rate |
controlled sodium chloride content diet (0.3 %) (for 21 days) then controlled sodium chloride content diet (8 %) (for 42 days) then 10% CO2, 20% O2, 70% N2 (between 0 and 0.4 hours) |
Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. |
heart pumping trait |
not specified |
86.0 days
| 5 |
sampling once per minute |
|
310.0 |
beats/min |
4.47 |
10.0 |
intra-aortic thoracic radiotelemetry |
|
0.0 |
|
|
|
|
|
103160 |
2787 |
| SR/Jr |
heart rate |
controlled sodium chloride content diet (0.3 %) (for 21 days) then controlled sodium chloride content diet (8 %) (for 42 days) then 10% CO2, 20% O2, 70% N2 (for 0.4 hours) then ambient air (between 0 and 0.1 hours) |
Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. |
heart pumping trait |
not specified |
86.0 days
| 5 |
sampling once per minute |
|
389.0 |
beats/min |
10.73 |
24.0 |
intra-aortic thoracic radiotelemetry |
|
0.0 |
5 |
min |
|
|
|
103162 |
2787 |
| SS/Jr |
mean arterial blood pressure |
controlled sodium chloride content diet (0.3 %) (for 21 days) then controlled sodium chloride content diet (8 %) (for 42 days) then ambient air (between 0 and 0.1 hours) |
Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. |
arterial blood pressure trait |
not specified |
86.0 days
| 5 |
sampling once per minute |
|
135.0 |
mmHg |
0.89 |
2.0 |
intra-aortic thoracic radiotelemetry |
|
0.0 |
|
|
|
|
|
103165 |
2787 |
| SS/Jr |
respiration rate |
controlled sodium chloride content diet (0.3 %) (for 21 days) then controlled sodium chloride content diet (8 %) (for 42 days) then 10% CO2, 20% O2, 70% N2 (10 %) (for 0.1 hours) |
Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. |
respiratory function trait |
not specified |
86.0 days
| 5 |
sampling once per minute |
|
145.0 |
breaths/min |
1.34 |
3.0 |
spirometry |
|
0.0 |
|
|
|
|
|
103177 |
2787 |
| SR/Jr |
heart rate |
controlled sodium chloride content diet (0.3 %) (for 21 days) then controlled sodium chloride content diet (8 %) (for 42 days) then atropine (1 mg/kg) (between 0.5 and 0.6 hours) then ambient air (between 0 and 0.1 hours) |
Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. |
heart pumping trait |
not specified |
86.0 days
| 5 |
sampling once per minute |
|
468.0 |
beats/min |
1.79 |
4.0 |
intra-aortic thoracic radiotelemetry |
|
0.0 |
|
|
|
|
|
103189 |
2787 |
| SS.BN-(D13Hmgc1048-D13Hmgc664)/Mcwi |
systolic blood pressure |
controlled sodium chloride content diet (0.4 %) (between 23 and 32 days) |
Cowley AW Jr, et al., Physiol Genomics. 2016 Jan;48(1):62-72. doi: 10.1152/physiolgenomics.00097.2015. Epub 2015 Nov 3. |
arterial blood pressure trait |
male |
44.0 days-53.0 days |
15 |
|
serial mean |
117.0 |
mmHg |
2.0 |
7.75 |
intra-aortic thoracic radiotelemetry via carotid cannulation |
|
10800.0 |
|
|
carotid a. to thoracic aorta implant |
strain 26-N |
|
98480 |
2079 |
| SD-Nfe2l2em1Mcwi-/- |
resting tone of middle cerebral artery |
controlled sodium chloride content diet (0.4 %) (between 70 and 84 days) then controlled sodium chloride content diet (4 %) (for 3 days) then angiotensin II (100 ng/kg/min) (for 3 days) |
Priestley JR, et al., Am J Physiol Heart Circ Physiol. 2016 Feb 15;310(4):H478-87. doi: 10.1152/ajpheart.00586.2015. Epub 2015 Dec 4. |
cerebral artery size trait |
male |
62.0 days-76.0 days |
5 |
[(Dmax - Drest) /Dmax] x 100 |
|
43.9 |
% |
4.99 |
11.16 |
isolated body part method |
|
0.0 |
|
|
|
tone |
|
100760 |
2520 |
| SR/JrHsd |
body weight |
controlled sodium chloride content diet (4 %) (for 14 days) then sham surgical control condition then peanut oil (0.2 ml) (for 14 days) |
Zheng W, et al., Am J Physiol Heart Circ Physiol. 2008 Apr;294(4):H1508-13. doi: 10.1152/ajpheart.01322.2007. Epub 2008 Feb 1. |
body mass |
female |
days
| |
|
|
232.0 |
g |
4.1 |
|
body weighing method |
|
0.0 |
|
|
|
|
|
102184 |
2681 |
| SR/JrHsd |
body weight |
controlled sodium chloride content diet (4 %) (for 14 days) then bilateral ovariectomy then 17 beta-estradiol (10 ug/d) (for 14 days) |
Zheng W, et al., Am J Physiol Heart Circ Physiol. 2008 Apr;294(4):H1508-13. doi: 10.1152/ajpheart.01322.2007. Epub 2008 Feb 1. |
body mass |
female |
days
| |
|
|
213.0 |
g |
2.2 |
|
body weighing method |
|
0.0 |
|
|
|
|
|
102188 |
2681 |
| SS/JrHsd |
body weight |
controlled sodium chloride content diet (4 %) (for 14 days) then sham surgical control condition then peanut oil (0.2 ml) (for 14 days) |
Zheng W, et al., Am J Physiol Heart Circ Physiol. 2008 Apr;294(4):H1508-13. doi: 10.1152/ajpheart.01322.2007. Epub 2008 Feb 1. |
body mass |
female |
days
| |
|
|
235.0 |
g |
13.0 |
|
body weighing method |
|
0.0 |
|
|
|
|
|
102190 |
2681 |
| SS/JrHsd |
body weight |
controlled sodium chloride content diet (4 %) (for 14 days) then bilateral ovariectomy then peanut oil (0.2 ml) (for 14 days) |
Zheng W, et al., Am J Physiol Heart Circ Physiol. 2008 Apr;294(4):H1508-13. doi: 10.1152/ajpheart.01322.2007. Epub 2008 Feb 1. |
body mass |
female |
days
| |
|
|
297.0 |
g |
5.1 |
|
body weighing method |
|
0.0 |
|
|
|
|
|
102192 |
2681 |
| SR/JrHsd |
single kidney wet weight |
controlled sodium chloride content diet (0.4 %) (for 14 days) then bilateral ovariectomy then peanut oil (0.2 ml) (for 14 days) |
Zheng W, et al., Am J Physiol Heart Circ Physiol. 2008 Apr;294(4):H1508-13. doi: 10.1152/ajpheart.01322.2007. Epub 2008 Feb 1. |
kidney mass |
female |
days
| |
|
|
0.85 |
g |
0.01 |
|
post excision weight measurement |
|
0.0 |
|
|
|
|
|
102197 |
2681 |
| SR/JrHsd |
single kidney wet weight |
controlled sodium chloride content diet (0.4 %) (for 14 days) then bilateral ovariectomy then 17 beta-estradiol (10 ug/d) (for 14 days) |
Zheng W, et al., Am J Physiol Heart Circ Physiol. 2008 Apr;294(4):H1508-13. doi: 10.1152/ajpheart.01322.2007. Epub 2008 Feb 1. |
kidney mass |
female |
days
| |
|
|
0.88 |
g |
0.02 |
|
post excision weight measurement |
|
0.0 |
|
|
|
|
|
102199 |
2681 |
| SR/JrHsd |
mean arterial blood pressure |
controlled sodium chloride content diet (0.4 %) (for 14 days) then bilateral ovariectomy then 17 beta-estradiol (10 ug/d) (for 14 days) |
Zheng W, et al., Am J Physiol Heart Circ Physiol. 2008 Apr;294(4):H1508-13. doi: 10.1152/ajpheart.01322.2007. Epub 2008 Feb 1. |
arterial blood pressure trait |
female |
days
| |
|
|
112.0 |
mmHg |
5.0 |
|
vascular fluid filled catheter |
|
0.0 |
|
|
|
|
|
102209 |
2681 |
| SS/NEisSlc |
kidney medullary adrenomedullin level |
controlled sodium chloride content diet (8 %) (for 21 days) |
Yoshihara F, et al., Regul Pept. 2005 May 15;128(1):7-13. |
kidney adrenomedullin amount |
male |
77.0 days
| 8 |
|
|
0.45 |
fmol/mg |
0.01 |
0.04 |
radioimmunoassay |
|
0.0 |
|
|
|
|
|
102452 |
2689 |
| SS/NEisSlc |
systolic blood pressure |
controlled sodium chloride content diet (8 %) (for 21 days) then adrenomedulin (9.6 ug/d) (for 21 days) |
Yoshihara F, et al., Regul Pept. 2005 May 15;128(1):7-13. |
arterial blood pressure trait |
male |
77.0 days
| 14 |
mean of 3 samples of undefined duration |
serial mean |
150.0 |
mmHg |
2.67 |
10.0 |
tail cuff plethysmography |
|
0.0 |
|
|
|
|
|
102467 |
2689 |
| SS/NEisSlc |
heart rate |
controlled sodium chloride content diet (0.3 %) (for 42 days) then controlled sodium chloride content diet (8 %) (for 84 days) |
Horinaka S, et al., Int J Cardiol. 2003 Sep;91(1):25-35. |
heart pumping trait |
male |
126.0 days
| 10 |
|
|
481.0 |
beats/min |
13.91 |
44.0 |
tail cuff plethysmography |
|
0.0 |
|
|
|
|
|
102499 |
2690 |
| SR/NEisSlc |
left ventricular systolic blood pressure |
controlled sodium chloride content diet (0.3 %) (for 42 days) then controlled sodium chloride content diet (8 %) (for 35 days) then pentobarbital (20 mg/kg) |
Horinaka S, et al., Int J Cardiol. 2003 Sep;91(1):25-35. |
heart left ventricular blood pressure trait |
male |
77.0 days
| 10 |
|
|
105.0 |
mmHg |
5.38 |
17.0 |
volume pressure recording |
|
0.0 |
|
|
|
|
|
102500 |
2690 |
| SS/NEisSlc |
left ventricular systolic blood pressure |
controlled sodium chloride content diet (0.3 %) (for 42 days) then controlled sodium chloride content diet (8 %) (for 35 days) then pentobarbital (20 mg/kg) |
Horinaka S, et al., Int J Cardiol. 2003 Sep;91(1):25-35. |
heart left ventricular blood pressure trait |
male |
77.0 days
| 10 |
|
|
149.0 |
mmHg |
6.01 |
19.0 |
volume pressure recording |
|
0.0 |
|
|
|
|
|
102502 |
2690 |
| SS/NEisSlc |
heart rate |
controlled sodium chloride content diet (0.3 %) (for 42 days) then controlled sodium chloride content diet (8 %) (for 35 days) then pentobarbital (20 mg/kg) |
Horinaka S, et al., Int J Cardiol. 2003 Sep;91(1):25-35. |
heart pumping trait |
male |
77.0 days
| 10 |
|
|
334.0 |
beats/min |
13.28 |
42.0 |
tail cuff plethysmography |
|
0.0 |
|
|
|
|
|
102506 |
2690 |
| SS/NEisSlc |
left ventricular end-diastolic blood pressure |
controlled sodium chloride content diet (0.3 %) (for 42 days) then controlled sodium chloride content diet (8 %) (for 35 days) then pentobarbital (20 mg/kg) |
Horinaka S, et al., Int J Cardiol. 2003 Sep;91(1):25-35. |
heart left ventricular blood pressure trait |
male |
77.0 days
| 10 |
|
|
5.4 |
mmHg |
0.7 |
2.2 |
volume pressure recording |
|
0.0 |
|
|
|
|
|
102510 |
2690 |
| SS/NEisSlc |
end-systolic volume |
controlled sodium chloride content diet (0.3 %) (for 42 days) then controlled sodium chloride content diet (8 %) (for 84 days) then pentobarbital (20 mg/kg) |
Horinaka S, et al., Int J Cardiol. 2003 Sep;91(1):25-35. |
cardiac output trait |
male |
126.0 days
| 10 |
|
|
0.13 |
ml |
0.02 |
0.07 |
volume pressure recording |
|
0.0 |
|
|
|
|
|
102515 |
2690 |
| SS/NEisSlc |
end-systolic volume |
controlled sodium chloride content diet (0.3 %) (for 42 days) then controlled sodium chloride content diet (8 %) (for 35 days) then pentobarbital (20 mg/kg) |
Horinaka S, et al., Int J Cardiol. 2003 Sep;91(1):25-35. |
cardiac output trait |
male |
77.0 days
| 10 |
|
|
0.03 |
ml |
0.0 |
0.01 |
volume pressure recording |
|
0.0 |
|
|
|
|
|
102514 |
2690 |
| SR/NEisSlc |
end-diastolic volume |
controlled sodium chloride content diet (0.3 %) (for 42 days) then controlled sodium chloride content diet (8 %) (for 35 days) then pentobarbital (20 mg/kg) |
Horinaka S, et al., Int J Cardiol. 2003 Sep;91(1):25-35. |
cardiac output trait |
male |
77.0 days
| 10 |
|
|
0.13 |
ml |
0.02 |
0.07 |
volume pressure recording |
|
0.0 |
|
|
|
|
|
102516 |
2690 |
| SS/NEisSlc |
heart left ventricle end-systolic elastance |
controlled sodium chloride content diet (0.3 %) (for 42 days) then controlled sodium chloride content diet (8 %) (for 84 days) then pentobarbital (20 mg/kg) |
Horinaka S, et al., Int J Cardiol. 2003 Sep;91(1):25-35. |
heart left ventricular blood pressure trait |
male |
126.0 days
| 10 |
|
|
1424.0 |
mmHg/ml |
118.59 |
375.0 |
volume pressure recording |
|
0.0 |
|
|
|
|
|
102523 |
2690 |
| SR/NEisSlc |
heart left ventricle systolic volume-axis intercept |
controlled sodium chloride content diet (0.3 %) (for 42 days) then controlled sodium chloride content diet (8 %) (for 84 days) then pentobarbital (20 mg/kg) |
Horinaka S, et al., Int J Cardiol. 2003 Sep;91(1):25-35. |
cardiac output trait |
male |
126.0 days
| 10 |
|
|
0.39 |
ml |
0.03 |
0.09 |
volume pressure recording |
|
0.0 |
|
|
|
|
|
102525 |
2690 |
| SS/NEisSlc |
heart left ventricle end-systolic elastance |
controlled sodium chloride content diet (0.3 %) (for 42 days) then controlled sodium chloride content diet (8 %) (for 35 days) then pentobarbital (20 mg/kg) |
Horinaka S, et al., Int J Cardiol. 2003 Sep;91(1):25-35. |
heart left ventricular blood pressure trait |
male |
77.0 days
| 10 |
|
|
3355.0 |
mmHg/ml |
331.41 |
1048.0 |
volume pressure recording |
|
0.0 |
|
|
|
|
|
102522 |
2690 |
| SS/NEisSlc |
heart left ventricle systolic volume-axis intercept |
controlled sodium chloride content diet (0.3 %) (for 42 days) then controlled sodium chloride content diet (8 %) (for 84 days) then pentobarbital (20 mg/kg) |
Horinaka S, et al., Int J Cardiol. 2003 Sep;91(1):25-35. |
cardiac output trait |
male |
126.0 days
| 10 |
|
|
0.29 |
ml |
0.02 |
0.07 |
volume pressure recording |
|
0.0 |
|
|
|
|
|
102527 |
2690 |
| SR/NEisSlc |
heart left ventricle diastolic volume-axis intercept |
controlled sodium chloride content diet (0.3 %) (for 42 days) then controlled sodium chloride content diet (8 %) (for 84 days) then pentobarbital (20 mg/kg) |
Horinaka S, et al., Int J Cardiol. 2003 Sep;91(1):25-35. |
cardiac output trait |
male |
126.0 days
| 10 |
|
|
0.09 |
ml |
0.02 |
0.06 |
volume pressure recording |
|
0.0 |
|
|
|
|
|
102533 |
2690 |
| SS/NEisSlc |
time constant of left ventricular pressure decay |
controlled sodium chloride content diet (0.3 %) (for 42 days) then controlled sodium chloride content diet (8 %) (for 84 days) then pentobarbital (20 mg/kg) |
Horinaka S, et al., Int J Cardiol. 2003 Sep;91(1):25-35. |
heart left ventricular blood pressure trait |
male |
126.0 days
| 10 |
|
|
13.3 |
ms |
0.79 |
2.5 |
volume pressure recording |
|
0.0 |
|
|
|
|
|
102537 |
2690 |
| SS/Jr |
tibia midshaft endosteal cross-sectional area |
controlled sodium chloride content diet (2 %) (between 38 and 42 days) |
Nie Y, et al., Physiol Genomics. 2016 Jun;48(6):409-19. doi: 10.1152/physiolgenomics.00004.2016. Epub 2016 Apr 25. |
tibia morphology trait |
male |
66.0 days-70.0 days |
|
|
|
3.02 |
mm2 |
0.09 |
|
micro-computed tomography |
|
0.0 |
|
|
|
|
|
98013 |
1958 |
| SS.BN-(D13Got45-D13Rat32)/Mcwi |
urine albumin excretion rate |
controlled sodium chloride content diet (0.4 %) (between 46 and 50.8 days) then controlled sodium chloride content diet (8 %) (for 13.4 days) |
Cowley AW, et al., Physiol Genomics. 2014 Jun 1;46(11):398-410. doi: 10.1152/physiolgenomics.00179.2013. Epub 2014 Apr 8. |
urine albumin amount |
male |
60.0 days-67.0 days |
12 |
|
|
165.0 |
mg/d |
26.0 |
90.07 |
urine microalbumin analysis |
|
0.0 |
|
|
|
strain 26-L |
|
98637 |
2098 |
| LH/MavRrrcAek |
mean arterial blood pressure |
standard rat chow (for 98 days) then controlled sodium chloride content diet (4 %) (for 21 days) |
Wang J, et al., Circ Cardiovasc Genet. 2015 Apr;8(2):316-26. doi: 10.1161/CIRCGENETICS.114.000520. Epub 2015 Jan 8. |
arterial blood pressure trait |
male |
119.0 days
| 9 |
mean of 15 sec every 5 min for 72 hours |
serial mean |
136.1 |
mmHg |
1.7 |
5.1 |
intra-aortic abdominal radiotelemetry via femoral cannulation |
|
0.0 |
|
|
|
|
|
102607 |
3014 |
| LN/MavRrrcAek |
systolic blood pressure |
standard rat chow (for 98 days) then controlled sodium chloride content diet (4 %) (for 21 days) |
Wang J, et al., Circ Cardiovasc Genet. 2015 Apr;8(2):316-26. doi: 10.1161/CIRCGENETICS.114.000520. Epub 2015 Jan 8. |
arterial blood pressure trait |
male |
119.0 days
| 14 |
mean of 15 sec every 5 min for 72 hours |
serial mean |
116.0 |
mmHg |
1.4 |
5.24 |
intra-aortic abdominal radiotelemetry via femoral cannulation |
|
0.0 |
|
|
|
|
|
102610 |
3014 |
| LN/MavRrrcAek |
plasma total cholesterol level |
standard rat chow (for 98 days) then controlled sodium chloride content diet (4 %) (for 14 days) |
Wang J, et al., Circ Cardiovasc Genet. 2015 Apr;8(2):316-26. doi: 10.1161/CIRCGENETICS.114.000520. Epub 2015 Jan 8. |
blood cholesterol amount |
male |
112.0 days
| 14 |
|
|
42.47 |
mg/dl |
4.63 |
17.34 |
plasma total cholesterol measurement test |
|
0.0 |
|
|
|
|
|
102634 |
3014 |
| SS.BN-(D13Hmgc885-D13Hmgc664)/Mcwi |
systolic blood pressure |
controlled sodium chloride content diet (0.4 %) (between 23 and 32 days) then controlled sodium chloride content diet (8 %) (for 14 days) |
Cowley AW Jr, et al., Physiol Genomics. 2016 Jan;48(1):62-72. doi: 10.1152/physiolgenomics.00097.2015. Epub 2015 Nov 3. |
arterial blood pressure trait |
male |
58.0 days-67.0 days |
10 |
|
serial mean |
168.0 |
mmHg |
5.0 |
15.81 |
intra-aortic thoracic radiotelemetry via carotid cannulation |
|
10800.0 |
|
|
carotid a. to thoracic aorta implant |
strain 26-R |
|
98505 |
2079 |
| SS.BN-(D13Got42-D13Hmgc354)/Mcwi |
mean arterial blood pressure |
controlled sodium chloride content diet (0.4 %) (between 46 and 50.8 days) then controlled sodium chloride content diet (8 %) (for 13.4 days) |
Cowley AW, et al., Physiol Genomics. 2014 Jun 1;46(11):398-410. doi: 10.1152/physiolgenomics.00179.2013. Epub 2014 Apr 8. |
arterial blood pressure trait |
male |
60.0 days-67.0 days |
16 |
|
serial mean |
161.0 |
mmHg |
5.0 |
20.0 |
intra-aortic thoracic radiotelemetry via carotid cannulation |
|
10800.0 |
|
|
intra-carotid radiotelemetry |
strain 26-D |
|
98556 |
2098 |
| SS.BN-(D13Rat111-D13Rat115)/Mcwi |
urine total protein excretion rate |
controlled sodium chloride content diet (0.4 %) (for 68 days) then controlled sodium chloride content diet (8 %) (for 21 days) |
Moreno C, et al., Am J Physiol Heart Circ Physiol. 2011 Apr;300(4):H1530-5. doi: 10.1152/ajpheart.01026.2010. Epub 2011 Jan 21. |
total urine protein amount |
male |
89.0 days
| 11 |
|
|
335.0 |
mg/d |
33.0 |
109.45 |
Bradford protein assay |
|
1.0 |
|
|
|
strain 5-8 |
|
98696 |
2138 |
| SR/Jr |
single kidney wet weight to body weight ratio |
controlled sodium chloride content diet (8 %) (for 35 days) |
Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. |
kidney mass |
male |
63.0 days
| 13 |
|
|
8.13 |
g/kg |
0.15 |
0.54 |
post excision weight measurement |
|
0.0 |
|
|
|
|
|
103243 |
2802 |
| SS/Jr |
single kidney wet weight to body weight ratio |
controlled sodium chloride content diet (0.3 %) (for 35 days) |
Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. |
kidney mass |
male |
63.0 days
| 15 |
|
|
6.39 |
g/kg |
0.13 |
0.5 |
post excision weight measurement |
|
0.0 |
|
|
|
|
|
103244 |
2802 |
| SR/Jr |
systolic blood pressure |
controlled sodium chloride content diet (0.3 %) (for 35 days) |
Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. |
arterial blood pressure trait |
male |
63.0 days
| 16 |
|
|
137.0 |
mmHg |
3.0 |
12.0 |
vascular transducer tipped catheter |
|
0.0 |
|
|
|
|
|
103246 |
2802 |
| SR/Jr |
mean arterial blood pressure |
controlled sodium chloride content diet (0.3 %) (for 35 days) |
Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. |
arterial blood pressure trait |
male |
63.0 days
| 16 |
|
|
113.0 |
mmHg |
2.0 |
8.0 |
vascular transducer tipped catheter |
|
0.0 |
|
|
|
|
|
103250 |
2802 |
| SS/Jr |
mean arterial blood pressure |
controlled sodium chloride content diet (8 %) (for 35 days) |
Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. |
arterial blood pressure trait |
male |
63.0 days
| 10 |
|
|
153.0 |
mmHg |
7.0 |
22.14 |
vascular transducer tipped catheter |
|
0.0 |
|
|
|
|
|
103253 |
2802 |
| SR/Jr |
plasma triglyceride level |
controlled sodium chloride content diet (0.3 %) (for 35 days) |
Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. |
blood triglyceride amount |
male |
63.0 days
| 16 |
|
|
0.43 |
mmol/l |
0.11 |
0.44 |
plasma triglyceride analysis |
|
0.0 |
|
|
|
|
|
103258 |
2802 |
| SS/Jr |
plasma total cholesterol level |
controlled sodium chloride content diet (8 %) (for 35 days) |
Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. |
blood cholesterol amount |
male |
63.0 days
| 10 |
|
|
111.97 |
mg/dl |
13.51 |
42.73 |
plasma total cholesterol measurement test |
|
0.0 |
|
|
|
|
|
103265 |
2802 |
| SS/Jr |
hematocrit |
controlled sodium chloride content diet (0.3 %) (for 35 days) |
Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. |
erythrocyte quantity |
male |
63.0 days
| 15 |
|
|
48.8 |
% |
0.5 |
1.94 |
hematocrit analysis |
|
0.0 |
|
|
|
|
|
103268 |
2802 |
| SR/Jr |
red blood cell sodium level |
controlled sodium chloride content diet (8 %) (for 35 days) |
Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. |
erythrocyte sodium amount |
male |
63.0 days
| 13 |
|
|
3.4 |
mmol/l |
0.06 |
0.22 |
ex vivo blood analysis |
|
0.0 |
|
|
|
|
|
103275 |
2802 |
| SS-Renem1Mcwi+/- |
serum bicarbonate level |
controlled sodium chloride content diet (0.4 %) (for 42 days) |
Moreno C, et al., Hypertension. 2011 Mar;57(3):614-9. doi: 10.1161/HYPERTENSIONAHA.110.163840. Epub 2011 Jan 17. |
blood bicarbonate amount |
male |
63.0 days
| 9 |
|
|
27.67 |
mmol/l |
0.5 |
1.5 |
automated serum bicarbonate test |
|
0.0 |
|
|
|
|
|
98368 |
2038 |
| SS-Renem1Mcwi+/+ |
diastolic blood pressure |
controlled sodium chloride content diet (0.4 %) (between 66 and 69 days) |
Moreno C, et al., Hypertension. 2011 Mar;57(3):614-9. doi: 10.1161/HYPERTENSIONAHA.110.163840. Epub 2011 Jan 17. |
arterial blood pressure trait |
male |
66.0 days-69.0 days |
5 |
|
serial mean |
101.76 |
mmHg |
2.81 |
6.28 |
intra-aortic abdominal radiotelemetry |
|
32400.0 |
|
|
|
|
|
98375 |
2038 |
| SS |
urine sodium level |
controlled sodium chloride content diet (8 %) (for 42 days) |
Wu F, et al., Int J Hypertens. 2016;2016:9146870. doi: 10.1155/2016/9146870. Epub 2016 Dec 19. |
urine sodium amount |
male |
91.0 days
| 8 |
|
|
1.7 |
mmol/l |
0.07 |
0.2 |
urine sodium analysis |
|
0.0 |
|
|
|
|
|
102284 |
2683 |
| SR/NEisSlc |
body weight |
controlled sodium chloride content diet (8 %) (for 14 days) |
Yoshihara F, et al., Regul Pept. 2005 May 15;128(1):7-13. |
body mass |
male |
70.0 days
| 8 |
|
|
309.0 |
g |
3.89 |
11.0 |
body weighing method |
|
0.0 |
|
|
|
|
|
102407 |
2689 |
| SS/NEisSlc |
body weight |
controlled sodium chloride content diet (8 %) (for 14 days) |
Yoshihara F, et al., Regul Pept. 2005 May 15;128(1):7-13. |
body mass |
male |
70.0 days
| 7 |
|
|
297.0 |
g |
5.29 |
14.0 |
body weighing method |
|
0.0 |
|
|
|
|
|
102408 |
2689 |
| SS/NEisSlc |
body weight |
controlled sodium chloride content diet (8 %) (for 21 days) |
Yoshihara F, et al., Regul Pept. 2005 May 15;128(1):7-13. |
body mass |
male |
77.0 days
| 8 |
|
|
342.0 |
g |
4.24 |
12.0 |
body weighing method |
|
0.0 |
|
|
|
|
|
102410 |
2689 |
| SS/NEisSlc |
single kidney wet weight to body weight ratio |
controlled sodium chloride content diet (8 %) (for 7 days) |
Yoshihara F, et al., Regul Pept. 2005 May 15;128(1):7-13. |
kidney mass |
male |
63.0 days
| 8 |
|
|
3.91 |
g/kg |
0.05 |
0.14 |
post excision weight measurement |
|
0.0 |
|
|
|
|
|
102424 |
2689 |
| SS/NEisSlc |
systolic blood pressure |
controlled sodium chloride content diet (8 %) (for 7 days) |
Yoshihara F, et al., Regul Pept. 2005 May 15;128(1):7-13. |
arterial blood pressure trait |
male |
63.0 days
| 8 |
mean of 3 samples of undefined duration |
serial mean |
126.0 |
mmHg |
2.12 |
6.0 |
tail cuff plethysmography |
|
0.0 |
|
|
|
|
|
102430 |
2689 |
| SR/NEisSlc |
systolic blood pressure |
controlled sodium chloride content diet (8 %) (for 21 days) |
Yoshihara F, et al., Regul Pept. 2005 May 15;128(1):7-13. |
arterial blood pressure trait |
male |
77.0 days
| 7 |
mean of 3 samples of undefined duration |
serial mean |
125.0 |
mmHg |
3.02 |
8.0 |
tail cuff plethysmography |
|
0.0 |
|
|
|
|
|
102433 |
2689 |
| SR/NEisSlc |
kidney cortical adrenomedullin level |
controlled sodium chloride content diet (8 %) (for 7 days) |
Yoshihara F, et al., Regul Pept. 2005 May 15;128(1):7-13. |
kidney adrenomedullin amount |
male |
63.0 days
| 7 |
|
|
0.59 |
fmol/mg |
0.04 |
0.1 |
radioimmunoassay |
|
0.0 |
|
|
|
|
|
102441 |
2689 |
| SS/NEisSlc |
kidney medullary adrenomedullin level |
controlled sodium chloride content diet (8 %) (for 7 days) |
Yoshihara F, et al., Regul Pept. 2005 May 15;128(1):7-13. |
kidney adrenomedullin amount |
male |
63.0 days
| 8 |
|
|
0.31 |
fmol/mg |
0.02 |
0.05 |
radioimmunoassay |
|
0.0 |
|
|
|
|
|
102448 |
2689 |
| SS/NEisSlc |
urine total protein excretion rate to body weight ratio |
controlled sodium chloride content diet (8 %) (for 7 days) then adrenomedulin (400 ng/hr) (for 7 days) |
Yoshihara F, et al., Regul Pept. 2005 May 15;128(1):7-13. |
total urine protein amount |
male |
63.0 days
| 14 |
|
|
3.5 |
mg/d/100 g |
0.27 |
1.0 |
urine protein analysis |
|
0.0 |
|
|
|
|
|
102473 |
2689 |
| SS-Nppaem4Mcwi-/- |
urine creatinine excretion rate |
controlled sodium chloride content diet (0.4 %) (between 56 and 63 days) then controlled sodium chloride content diet (4 %) (for 12 days) |
Flister MJ, et al., Genome Res. 2013 Dec;23(12):1996-2002. doi: 10.1101/gr.160283.113. Epub 2013 Sep 4. |
urine creatinine amount |
male |
60.0 days-69.0 days |
|
|
|
10.1 |
mg/d |
0.3 |
|
urine creatinine analysis |
|
0.0 |
|
|
|
|
|
98439 |
2059 |
| LN/MavRrrcAek |
plasma leptin level |
standard rat chow (for 98 days) then controlled sodium chloride content diet (4 %) (for 28 days) |
Wang J, et al., Circ Cardiovasc Genet. 2015 Apr;8(2):316-26. doi: 10.1161/CIRCGENETICS.114.000520. Epub 2015 Jan 8. |
blood leptin amount |
male |
126.0 days
| 11 |
|
|
0.35 |
ng/ml |
0.03 |
0.16 |
plasma leptin analysis |
|
0.0 |
|
|
automated plasma leptin analysis |
|
|
105320 |
3014 |
| SS-Shc1em1Mcwi |
renal afferent arteriole diameter |
controlled sodium chloride content diet (1 %) (between 70 and 91 days) then controlled ex vivo artery perfusion pressure (60 mmHg) (for 0.1 hours) |
Miller B, et al., J Clin Invest. 2016 Jul 1;126(7):2533-46. doi: 10.1172/JCI75079. Epub 2016 Jun 6. |
kidney arteriole morphology trait |
not specified |
91.0 days-133.0 days |
5 |
|
|
23.4 |
um |
1.4 |
3.13 |
ex vivo videomicroscopy |
renal afferent arteriole |
120.0 |
|
|
ex vivo videomicroscopy (MMO:0000319) |
renal afferent arteriole diameter (CMO:0003725) |
renal arteriole morphology trait |
106496 |
3030 |
| SS/JrHsdMcwi |
renal afferent arteriole diameter |
controlled sodium chloride content diet (1 %) (between 70 and 91 days) then controlled ex vivo artery perfusion pressure (60 mmHg) (for 0.1 hours) |
Miller B, et al., J Clin Invest. 2016 Jul 1;126(7):2533-46. doi: 10.1172/JCI75079. Epub 2016 Jun 6. |
kidney arteriole morphology trait |
not specified |
91.0 days-133.0 days |
8 |
|
|
24.1 |
um |
0.8 |
2.26 |
ex vivo videomicroscopy |
renal afferent arteriole |
120.0 |
|
|
ex vivo videomicroscopy (MMO:0000319) |
renal afferent arteriole diameter (CMO:0003725) |
renal arteriole morphology trait |
106499 |
3030 |
| SS/JrHsdMcwi |
blood mononuclear cell count |
controlled sodium chloride content diet (0.4 %) (for 21 days) |
Rudemiller NP, et al., Hypertension. 2015 May;65(5):1111-7. doi: 10.1161/HYPERTENSIONAHA.114.04736. Epub 2015 Mar 16. |
leukocyte quantity |
not specified |
84.0 days
| 4 |
|
|
5.9 |
x 10E6 cells/ml |
0.9 |
1.8 |
flow cytometry method |
|
0.0 |
|
|
|
n=4-7 |
|
106510 |
3031 |
| SS-Sh2b3em1Mcwi-/- |
blood regulatory T cell count to total T cell count ratio |
controlled sodium chloride content diet (0.4 %) (for 42 days) |
Rudemiller NP, et al., Hypertension. 2015 May;65(5):1111-7. doi: 10.1161/HYPERTENSIONAHA.114.04736. Epub 2015 Mar 16. |
T cell quantity |
not specified |
63.0 days
| 4 |
|
|
4.9 |
% |
0.1 |
0.2 |
flow cytometry method |
|
0.0 |
|
|
|
n=4-7 -tregs spleen % |
|
106519 |
3031 |
| SS/JrHsdMcwi |
urine albumin excretion rate |
controlled sodium chloride content diet (0.4 %) (for 42 days) then controlled sodium chloride content diet (4 %) (for 21 days) |
Rudemiller NP, et al., Hypertension. 2015 May;65(5):1111-7. doi: 10.1161/HYPERTENSIONAHA.114.04736. Epub 2015 Mar 16. |
urine albumin amount |
not specified |
84.0 days
| 6 |
|
|
104.9 |
mg/d |
8.9 |
21.8 |
urine albumin analysis |
|
0.0 |
|
|
|
n=6-8 |
|
106528 |
3031 |
| SS/JrHsdMcwi |
kidney total CD3 positive T cell count |
controlled sodium chloride content diet (0.4 %) (for 42 days) then controlled sodium chloride content diet (4 %) (for 21 days) |
Rudemiller NP, et al., Hypertension. 2015 May;65(5):1111-7. doi: 10.1161/HYPERTENSIONAHA.114.04736. Epub 2015 Mar 16. |
T cell quantity |
not specified |
84.0 days
| 5 |
|
|
0.42 |
x 10E6 cells/ml |
0.04 |
0.09 |
flow cytometry method |
|
0.0 |
|
|
|
n=5-6 (tissue T cell count) |
|
106532 |
3031 |
| SBH/Ygl |
systolic blood pressure |
controlled sodium chloride content diet (8 %) (for 42 days) then streptozotocin (60 mg/kg) then insulin (10 ul) (for 42 days) |
Landau D, et al., J Endocrinol. 2008 Apr;197(1):75-83. doi: 10.1677/JOE-08-0040. |
arterial blood pressure trait |
male |
98.0 days
| 7 |
|
|
181.0 |
mmHg |
2.0 |
5.29 |
tail cuff plethysmography |
|
0.0 |
|
|
|
|
|
106699 |
3038 |
| SBH/Ygl |
food intake weight to body weight ratio |
controlled sodium chloride content diet (0.65 %) (for 84 days) |
Landau D, et al., J Endocrinol. 2008 Apr;197(1):75-83. doi: 10.1677/JOE-08-0040. |
eating behavior trait |
male |
84.0 days
| 7 |
|
|
9.47 |
g/d/100g |
0.69 |
1.83 |
food intake measuring method |
|
0.0 |
|
|
|
|
|
106704 |
3038 |
| SBH/Ygl |
heart weight |
controlled sodium chloride content diet (0.65 %) (for 98 days) |
Landau D, et al., J Endocrinol. 2008 Apr;197(1):75-83. doi: 10.1677/JOE-08-0040. |
heart mass |
male |
98.0 days
| 7 |
|
|
1.05 |
g |
0.04 |
0.1 |
post excision weight measurement |
|
0.0 |
|
|
|
|
|
106708 |
3038 |
| SBH/Ygl |
heart left ventricle fractional shortening |
controlled sodium chloride content diet (0.65 %) (for 98 days) |
Landau D, et al., J Endocrinol. 2008 Apr;197(1):75-83. doi: 10.1677/JOE-08-0040. |
heart left ventricle end-diastolic diameter |
male |
98.0 days
| 7 |
|
|
66.0 |
% |
1.0 |
2.65 |
transthoracic echocardiography |
|
0.0 |
|
|
|
|
|
106712 |
3038 |
| SBH/Ygl |
heart left ventricle end-diastolic diameter to body weight ratio |
controlled sodium chloride content diet (8 %) (for 42 days) |
Landau D, et al., J Endocrinol. 2008 Apr;197(1):75-83. doi: 10.1677/JOE-08-0040. |
heart left ventricle end-diastolic diameter |
male |
98.0 days
| 7 |
|
|
2.2 |
mm/kg |
0.1 |
0.26 |
transthoracic echocardiography |
|
0.0 |
|
|
|
|
|
106717 |
3038 |
| SBH/Ygl |
heart left ventricle end-diastolic diameter to body weight ratio |
controlled sodium chloride content diet (8 %) (for 42 days) then streptozotocin (60 mg/kg) then insulin (10 ul) (for 42 days) |
Landau D, et al., J Endocrinol. 2008 Apr;197(1):75-83. doi: 10.1677/JOE-08-0040. |
heart left ventricle end-diastolic diameter |
male |
98.0 days
| 7 |
|
|
2.7 |
mm/kg |
0.1 |
0.26 |
transthoracic echocardiography |
|
0.0 |
|
|
|
|
|
106719 |
3038 |
| SBH/Ygl |
heart left ventricle end-diastolic diameter to body weight ratio |
controlled sodium chloride content diet (0.65 %) (for 98 days) then streptozotocin (60 mg/kg) then insulin (10 ul) (for 42 days) |
Landau D, et al., J Endocrinol. 2008 Apr;197(1):75-83. doi: 10.1677/JOE-08-0040. |
heart left ventricle end-diastolic diameter |
male |
98.0 days
| 7 |
|
|
2.6 |
mm/kg |
0.2 |
0.53 |
transthoracic echocardiography |
|
0.0 |
|
|
|
|
|
106718 |
3038 |
| SS/HsdMcwiCrl |
heart rate |
controlled sodium chloride content diet (0.1 %) (between 28 and 42 days) then 2% dimethyl sulfoxide in artificial cerebrospinal fluid (300 nl/min) (for 0.2 hours) then kynurenate (0.14 ug/min) (for 0.2 hours) |
Gabor A and Leenen FH, Brain Res. 2012 Apr 4;1447:28-37. doi: 10.1016/j.brainres.2012.01.060. Epub 2012 Feb 1. |
heart pumping trait |
male |
77.0 days-98.0 days |
4 |
|
|
442.0 |
beats/min |
5.0 |
10.0 |
vascular fluid filled catheter |
femoral artery |
600.0 |
|
|
|
|
|
106778 |
2685 |
| SS-Chr 13BN/McwiCrl |
heart rate |
controlled sodium chloride content diet (0.1 %) (between 28 and 42 days) then candesartan (0.5 ug/min) (for 0.2 hours) then kynurenate (0.14 ug/min) (for 0.2 hours) |
Gabor A and Leenen FH, Brain Res. 2012 Apr 4;1447:28-37. doi: 10.1016/j.brainres.2012.01.060. Epub 2012 Feb 1. |
heart pumping trait |
male |
77.0 days-98.0 days |
4 |
|
|
409.0 |
beats/min |
7.0 |
14.0 |
vascular fluid filled catheter |
femoral artery |
600.0 |
|
|
|
|
|
106780 |
2685 |
| SR/Jr |
maximum rate of positive change in left ventricular blood pressure to left ventricular systolic blood pressure ratio |
controlled sodium chloride content diet (0.3 %) (for 21 days) then controlled sodium chloride content diet (8 %) (for 42 days) then pentobarbital, sodium (20 mg/kg) |
Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. |
heart left ventricular blood pressure trait |
not specified |
84.0 days
| 5 |
LVdP/dtmax/P |
|
72.0 |
/s |
4.02 |
1.0 |
vascular transducer tipped catheter |
|
0.0 |
|
|
|
|
|
106816 |
2787 |
| SR/Jr |
minimum rate of positive change in left ventricular blood pressure |
controlled sodium chloride content diet (0.3 %) (for 21 days) then controlled sodium chloride content diet (8 %) (for 42 days) then pentobarbital, sodium (20 mg/kg) |
Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. |
heart left ventricular blood pressure trait |
not specified |
84.0 days
| 5 |
LVdP/dtmin |
|
8.2 |
10E3 mmHg/s |
4.47 |
1.2 |
vascular transducer tipped catheter |
|
0.0 |
|
|
|
minimum rate of positive change in left ventricular blood pressure |
|
106818 |
2787 |
| SS/HsdMcwiCrl |
mean arterial blood pressure |
controlled sodium chloride content diet (8 %) (between 28 and 42 days) then 2% dimethyl sulfoxide in artificial cerebrospinal fluid (300 nl/min) (for 0.2 hours) then kynurenate (0.14 ug/min) (for 0.2 hours) |
Gabor A and Leenen FH, Brain Res. 2012 Apr 4;1447:28-37. doi: 10.1016/j.brainres.2012.01.060. Epub 2012 Feb 1. |
arterial blood pressure trait |
male |
77.0 days-98.0 days |
4 |
MAP=.33(SP-DP) + DP |
|
150.0 |
mmHg |
8.0 |
16.0 |
vascular fluid filled catheter |
femoral artery |
600.0 |
|
|
|
|
|
106762 |
2685 |
| SS-Chr 13BN/McwiCrl |
mean arterial blood pressure |
controlled sodium chloride content diet (0.1 %) (between 28 and 42 days) then candesartan (0.5 ug/min) (for 0.2 hours) then kynurenate (0.14 ug/min) (for 0.2 hours) |
Gabor A and Leenen FH, Brain Res. 2012 Apr 4;1447:28-37. doi: 10.1016/j.brainres.2012.01.060. Epub 2012 Feb 1. |
arterial blood pressure trait |
male |
77.0 days-98.0 days |
4 |
MAP=.33(SP-DP) + DP |
|
104.0 |
mmHg |
3.0 |
6.0 |
vascular fluid filled catheter |
femoral artery |
600.0 |
|
|
|
|
|
106763 |
2685 |
| SS/HsdMcwiCrl |
mean arterial blood pressure |
controlled sodium chloride content diet (8 %) (between 28 and 42 days) |
Gabor A and Leenen FH, Brain Res. 2012 Apr 4;1447:28-37. doi: 10.1016/j.brainres.2012.01.060. Epub 2012 Feb 1. |
arterial blood pressure trait |
male |
77.0 days-98.0 days |
5 |
MAP=.33(SP-DP) + DP |
|
149.0 |
mmHg |
3.0 |
6.71 |
vascular fluid filled catheter |
femoral artery |
600.0 |
|
|
|
|
|
106768 |
2685 |
| SBH/Ygl |
blood glucose level |
controlled sodium chloride content diet (0.65 %) (for 98 days) |
Landau D, et al., J Endocrinol. 2008 Apr;197(1):75-83. doi: 10.1677/JOE-08-0040. |
blood glucose amount |
male |
98.0 days
| 7 |
|
|
113.4 |
mg/dl |
3.6 |
9.52 |
blood glucose test strip read by electrochemical glucometer |
|
0.0 |
|
|
|
|
|
106692 |
3038 |
| SS-Chr 13BN/McwiCrl |
heart rate |
controlled sodium chloride content diet (0.1 %) (between 28 and 42 days) |
Gabor A and Leenen FH, Brain Res. 2012 Apr 4;1447:28-37. doi: 10.1016/j.brainres.2012.01.060. Epub 2012 Feb 1. |
heart pumping trait |
male |
77.0 days-98.0 days |
4 |
|
|
408.0 |
beats/min |
6.0 |
12.0 |
vascular fluid filled catheter |
femoral artery |
600.0 |
|
|
|
|
|
106772 |
2685 |
| MWF/Fub |
kidney weight |
controlled sodium chloride content diet (8 %) (for 56 days) |
Kreutz R, etal., J Hypertens. 2000 Jun;18(6):777-82. doi: 10.1097/00004872-200018060-00017. |
kidney mass |
male |
104.0 days
| 8 |
|
|
1.08 |
g |
0.02 |
0.06 |
post excision weight measurement |
kidney |
0.0 |
|
|
|
|
|
109011 |
3134 |
| LEW/Mol |
kidney weight |
controlled sodium chloride content diet (8 %) (for 56 days) |
Kreutz R, etal., J Hypertens. 2000 Jun;18(6):777-82. doi: 10.1097/00004872-200018060-00017. |
kidney mass |
female |
104.0 days
| 8 |
|
|
0.87 |
g |
0.01 |
0.03 |
post excision weight measurement |
kidney |
0.0 |
|
|
|
|
|
109006 |
3134 |
| SR/Jr |
ouabain-sensitive red blood cell Na+ export rate |
controlled sodium chloride content diet (8 %) (for 35 days) |
Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. |
erythrocyte ion transport trait |
male |
63.0 days
| 13 |
|
|
3483.0 |
umol/l/h |
104.0 |
374.98 |
Na+/K+ ATPase activity assay |
|
0.0 |
|
|
|
|
|
111034 |
2802 |
| SR/Jr |
bumetanide-sensitive red blood cell Na+ export rate |
controlled sodium chloride content diet (8 %) (for 35 days) |
Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. |
erythrocyte ion transport trait |
male |
63.0 days
| 13 |
|
|
194.0 |
umol/l/h |
78.0 |
281.23 |
Na-K-Cl cotransport activity assay |
|
0.0 |
|
|
|
|
|
111038 |
2802 |
| SR/Jr |
ouabain-sensitive red blood cell K+ import rate |
controlled sodium chloride content diet (8 %) (for 35 days) |
Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. |
erythrocyte ion transport trait |
male |
63.0 days
| 13 |
|
|
4255.0 |
umol/l/h |
130.0 |
468.72 |
Na+/K+ ATPase activity assay |
|
0.0 |
|
|
|
|
|
111046 |
2802 |
| SR/Jr |
ouabain-sensitive red blood cell K+ import rate |
controlled sodium chloride content diet (0.3 %) (for 35 days) |
Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. |
erythrocyte ion transport trait |
male |
63.0 days
| 16 |
|
|
4275.0 |
umol/l/h |
135.0 |
540.0 |
Na+/K+ ATPase activity assay |
|
0.0 |
|
|
|
|
|
111045 |
2802 |
| SS/Jr |
bumetanide-sensitive red blood cell K+ import rate |
controlled sodium chloride content diet (0.3 %) (for 35 days) |
Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. |
erythrocyte ion transport trait |
male |
63.0 days
| 15 |
|
|
775.0 |
umol/l/h |
65.0 |
251.74 |
Na-K-Cl cotransport activity assay |
|
0.0 |
|
|
|
|
|
111051 |
2802 |
| SR/Jr |
ouabain- and bumetanide-resistant red blood cell K+ import rate |
controlled sodium chloride content diet (8 %) (for 35 days) |
Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. |
erythrocyte ion transport trait |
male |
63.0 days
| 13 |
|
|
408.0 |
umol/l/h |
14.0 |
50.48 |
Na+ passive permeability assay |
|
0.0 |
|
|
|
|
|
111054 |
2802 |
| SS/Jr |
ouabain- and bumetanide-resistant red blood cell K+ import rate |
controlled sodium chloride content diet (8 %) (for 35 days) |
Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. |
erythrocyte ion transport trait |
male |
63.0 days
| 10 |
|
|
499.0 |
umol/l/h |
33.0 |
104.36 |
Na+ passive permeability assay |
|
0.0 |
|
|
|
|
|
111056 |
2802 |
| MWF/Fub |
kidney wet weight to body weight ratio |
controlled sodium chloride content diet (8 %) (for 56 days) |
Kreutz R, etal., J Hypertens. 2000 Jun;18(6):777-82. doi: 10.1097/00004872-200018060-00017. |
kidney mass |
male |
104.0 days
| 8 |
|
|
3.49 |
mg/g |
0.1 |
0.28 |
post excision weight measurement |
kidney |
0.0 |
|
|
|
|
|
109019 |
3134 |
| MWF/Fub |
systolic blood pressure |
controlled sodium chloride content diet (8 %) (for 56 days) |
Kreutz R, etal., J Hypertens. 2000 Jun;18(6):777-82. doi: 10.1097/00004872-200018060-00017. |
arterial blood pressure trait |
female |
100.0 days-103.0 days |
8 |
|
|
134.0 |
mmHg |
3.0 |
8.49 |
tail cuff plethysmography |
tail |
0.0 |
|
|
|
|
|
109022 |
3134 |
| SD-Nfe2l2em1Mcwi+/+ |
mean arterial blood pressure |
controlled sodium chloride content diet (0.4 %) (between 35 and 49 days) |
Priestley JR, et al., Am J Physiol Heart Circ Physiol. 2016 Feb 15;310(4):H478-87. doi: 10.1152/ajpheart.00586.2015. Epub 2015 Dec 4. |
arterial blood pressure trait |
male |
56.0 days-70.0 days |
4 |
|
|
92.0 |
mmHg |
2.8 |
5.6 |
vascular fluid filled catheter |
|
0.0 |
|
|
|
|
|
100737 |
2520 |
| SD-Nfe2l2em1Mcwi+/+ |
mean arterial blood pressure |
controlled sodium chloride content diet (0.4 %) (between 70 and 84 days) then controlled sodium chloride content diet (4 %) (for 3 days) then 0.9% sodium chloride solution (for 3 days) |
Priestley JR, et al., Am J Physiol Heart Circ Physiol. 2016 Feb 15;310(4):H478-87. doi: 10.1152/ajpheart.00586.2015. Epub 2015 Dec 4. |
arterial blood pressure trait |
male |
62.0 days-76.0 days |
4 |
|
|
95.0 |
mmHg |
3.9 |
7.8 |
vascular fluid filled catheter |
|
0.0 |
|
|
|
|
|
100739 |
2520 |
| SD-Nfe2l2em1Mcwi+/+ |
resting tone of middle cerebral artery |
controlled sodium chloride content diet (0.4 %) (between 70 and 84 days) |
Priestley JR, et al., Am J Physiol Heart Circ Physiol. 2016 Feb 15;310(4):H478-87. doi: 10.1152/ajpheart.00586.2015. Epub 2015 Dec 4. |
cerebral artery size trait |
male |
56.0 days-70.0 days |
4 |
[(Dmax - Drest) /Dmax] x 100 |
|
50.8 |
% |
3.39 |
6.78 |
isolated body part method |
|
0.0 |
|
|
|
tone |
|
100755 |
2520 |
| SD-Nfe2l2em1Mcwi-/- |
mean arterial blood pressure |
controlled sodium chloride content diet (0.4 %) (between 70 and 84 days) then controlled sodium chloride content diet (4 %) (for 3 days) then 0.9% sodium chloride solution (for 3 days) |
Priestley JR, et al., Am J Physiol Heart Circ Physiol. 2016 Feb 15;310(4):H478-87. doi: 10.1152/ajpheart.00586.2015. Epub 2015 Dec 4. |
arterial blood pressure trait |
male |
62.0 days-76.0 days |
3 |
|
|
102.0 |
mmHg |
3.0 |
5.2 |
vascular fluid filled catheter |
|
0.0 |
|
|
|
|
|
100740 |
2520 |
| SD-Nfe2l2em1Mcwi-/- |
resting tone of middle cerebral artery |
controlled sodium chloride content diet (0.4 %) (between 70 and 84 days) |
Priestley JR, et al., Am J Physiol Heart Circ Physiol. 2016 Feb 15;310(4):H478-87. doi: 10.1152/ajpheart.00586.2015. Epub 2015 Dec 4. |
cerebral artery size trait |
male |
56.0 days-70.0 days |
4 |
[(Dmax - Drest) /Dmax] x 100 |
|
53.9 |
% |
3.29 |
6.58 |
isolated body part method |
|
0.0 |
|
|
|
tone |
|
100756 |
2520 |
| SD-Nfe2l2em1Mcwi+/+ |
resting tone of middle cerebral artery |
controlled sodium chloride content diet (0.4 %) (between 70 and 84 days) then controlled sodium chloride content diet (4 %) (for 3 days) then angiotensin II (100 ng/kg/min) (for 3 days) |
Priestley JR, et al., Am J Physiol Heart Circ Physiol. 2016 Feb 15;310(4):H478-87. doi: 10.1152/ajpheart.00586.2015. Epub 2015 Dec 4. |
cerebral artery size trait |
male |
62.0 days-76.0 days |
4 |
[(Dmax - Drest) /Dmax] x 100 |
|
47.3 |
% |
4.48 |
8.96 |
isolated body part method |
|
0.0 |
|
|
|
tone |
|
100759 |
2520 |
| SR/JrHsd |
adrenal angiotensin II type 1 receptor density |
controlled sodium chloride content diet (4 %) (for 14 days) then bilateral ovariectomy then peanut oil (0.2 ml) (for 14 days) |
Zheng W, et al., Am J Physiol Heart Circ Physiol. 2008 Apr;294(4):H1508-13. doi: 10.1152/ajpheart.01322.2007. Epub 2008 Feb 1. |
adrenal gland molecular composition trait |
female |
days
| |
|
|
154.0 |
fmol/mg |
24.0 |
|
radioimmunoassay |
|
0.0 |
|
|
|
|
|
102226 |
2681 |
| SR/JrHsd |
adrenal angiotensin II type 1 receptor density |
controlled sodium chloride content diet (0.4 %) (for 14 days) then bilateral ovariectomy then 17 beta-estradiol (10 ug/d) (for 14 days) |
Zheng W, et al., Am J Physiol Heart Circ Physiol. 2008 Apr;294(4):H1508-13. doi: 10.1152/ajpheart.01322.2007. Epub 2008 Feb 1. |
adrenal gland molecular composition trait |
female |
days
| |
|
|
103.0 |
fmol/mg |
13.0 |
|
radioimmunoassay |
|
0.0 |
|
|
|
|
|
102227 |
2681 |
| SS/Jr |
ouabain-sensitive red blood cell Na+ export rate |
controlled sodium chloride content diet (8 %) (for 35 days) |
Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. |
erythrocyte ion transport trait |
male |
63.0 days
| 10 |
|
|
5475.0 |
umol/l/h |
442.0 |
1397.73 |
Na+/K+ ATPase activity assay |
|
0.0 |
|
|
|
|
|
111036 |
2802 |
| SS |
body weight |
controlled sodium chloride content diet (8 %) (for 42 days) |
Wu F, et al., Int J Hypertens. 2016;2016:9146870. doi: 10.1155/2016/9146870. Epub 2016 Dec 19. |
body mass |
male |
91.0 days
| 8 |
|
|
309.0 |
g |
6.36 |
18.0 |
body weighing method |
|
0.0 |
|
|
|
|
|
102272 |
2683 |
| SR/Jr |
heart weight to body weight ratio |
controlled sodium chloride content diet (0.3 %) (for 21 days) then controlled sodium chloride content diet (8 %) (for 42 days) |
Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. |
heart mass |
not specified |
84.0 days
| 5 |
|
|
3.22 |
g/kg |
0.12 |
0.27 |
post excision weight measurement |
|
0.0 |
|
|
|
|
|
103146 |
2787 |
| SS/Jr |
heart rate |
controlled sodium chloride content diet (0.3 %) (for 21 days) then controlled sodium chloride content diet (8 %) (for 42 days) then 10% CO2, 20% O2, 70% N2 (between 0 and 0.1 hours) |
Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. |
heart pumping trait |
not specified |
86.0 days
| 5 |
sampling once per minute |
|
343.0 |
beats/min |
5.81 |
13.0 |
intra-aortic thoracic radiotelemetry |
|
0.0 |
|
|
|
|
|
103157 |
2787 |
| SS/Jr |
heart rate |
controlled sodium chloride content diet (0.3 %) (for 21 days) then controlled sodium chloride content diet (8 %) (for 42 days) then 10% CO2, 20% O2, 70% N2 (for 0.4 hours) then ambient air (between 0 and 0.4 hours) |
Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. |
heart pumping trait |
not specified |
86.0 days
| 5 |
sampling once per minute |
|
428.0 |
beats/min |
10.73 |
24.0 |
intra-aortic thoracic radiotelemetry |
|
0.0 |
25 |
min |
|
|
|
103163 |
2787 |
| SR/Jr |
heart rate |
controlled sodium chloride content diet (0.3 %) (for 21 days) then controlled sodium chloride content diet (8 %) (for 42 days) then 10% CO2, 20% O2, 70% N2 (for 0.4 hours) then ambient air (between 0 and 0.4 hours) |
Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. |
heart pumping trait |
not specified |
86.0 days
| 5 |
sampling once per minute |
|
356.0 |
beats/min |
10.73 |
24.0 |
intra-aortic thoracic radiotelemetry |
|
0.0 |
25 |
min |
|
|
|
103164 |
2787 |
| SS/Jr |
mean arterial blood pressure |
controlled sodium chloride content diet (0.3 %) (for 42 days) then controlled sodium chloride content diet (8 %) (for 42 days) then 10% CO2, 20% O2, 70% N2 (between 0 and 0.1 hours) |
Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. |
arterial blood pressure trait |
not specified |
86.0 days
| 5 |
sampling once per minute |
|
144.0 |
mmHg |
1.34 |
3.0 |
intra-aortic thoracic radiotelemetry |
|
0.0 |
|
|
|
|
|
103167 |
2787 |
| SS/Jr |
mean arterial blood pressure |
controlled sodium chloride content diet (0.3 %) (for 42 days) then controlled sodium chloride content diet (8 %) (for 42 days) then 10% CO2, 20% O2, 70% N2 (between 0 and 0.4 hours) |
Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. |
arterial blood pressure trait |
not specified |
86.0 days
| 5 |
sampling once per minute |
|
142.0 |
mmHg |
1.34 |
3.0 |
intra-aortic thoracic radiotelemetry |
|
0.0 |
|
|
|
|
|
103169 |
2787 |
| SR/Jr |
mean arterial blood pressure |
controlled sodium chloride content diet (0.3 %) (for 42 days) then controlled sodium chloride content diet (8 %) (for 42 days) then 10% CO2, 20% O2, 70% N2 (between 0 and 0.4 hours) |
Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. |
arterial blood pressure trait |
not specified |
86.0 days
| 5 |
sampling once per minute |
|
107.0 |
mmHg |
1.34 |
3.0 |
intra-aortic thoracic radiotelemetry |
|
0.0 |
|
|
|
|
|
103170 |
2787 |
| SS/Jr |
mean arterial blood pressure |
controlled sodium chloride content diet (0.3 %) (for 42 days) then controlled sodium chloride content diet (8 %) (for 42 days) then 10% CO2, 20% O2, 70% N2 (between 0 and 0.4 hours) then ambient air (between 0 and 0.1 hours) |
Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. |
arterial blood pressure trait |
not specified |
86.0 days
| 5 |
sampling once per minute |
|
142.0 |
mmHg |
2.24 |
5.0 |
intra-aortic thoracic radiotelemetry |
|
0.0 |
|
|
|
|
|
103171 |
2787 |
| SS/Jr |
mean arterial blood pressure |
controlled sodium chloride content diet (0.3 %) (for 42 days) then controlled sodium chloride content diet (8 %) (for 42 days) then 10% CO2, 20% O2, 70% N2 (between 0 and 0.4 hours) then ambient air (between 0 and 0.4 hours) |
Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. |
arterial blood pressure trait |
not specified |
86.0 days
| 5 |
sampling once per minute |
|
139.0 |
mmHg |
2.24 |
5.0 |
intra-aortic thoracic radiotelemetry |
|
0.0 |
|
|
|
|
|
103173 |
2787 |
| SR/Jr |
respiration rate |
controlled sodium chloride content diet (0.3 %) (for 21 days) then controlled sodium chloride content diet (8 %) (for 42 days) then 10% CO2, 20% O2, 70% N2 (10 %) (for 0.1 hours) |
Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. |
respiratory function trait |
not specified |
86.0 days
| 5 |
sampling once per minute |
|
144.0 |
breaths/min |
1.34 |
3.0 |
spirometry |
|
0.0 |
|
|
|
|
|
103178 |
2787 |
| SR/Jr |
respiration rate |
controlled sodium chloride content diet (0.3 %) (for 21 days) then controlled sodium chloride content diet (8 %) (for 42 days) then ambient air (between 0 and 0.1 hours) |
Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. |
respiratory function trait |
not specified |
86.0 days
| 5 |
sampling once per minute |
|
120.0 |
breaths/min |
1.79 |
4.0 |
spirometry |
|
0.0 |
|
|
|
|
|
103176 |
2787 |
| SS/Jr |
heart rate |
controlled sodium chloride content diet (0.3 %) (for 21 days) then controlled sodium chloride content diet (8 %) (for 42 days) then atropine (1 mg/kg) (between 0.5 and 0.6 hours) then ambient air (between 0 and 0.1 hours) |
Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. |
heart pumping trait |
not specified |
86.0 days
| 4 |
sampling once per minute |
|
455.0 |
beats/min |
2.5 |
5.0 |
intra-aortic thoracic radiotelemetry |
|
0.0 |
|
|
|
|
|
103188 |
2787 |
| SS/Jr |
mean arterial blood pressure |
controlled sodium chloride content diet (0.3 %) (for 42 days) then controlled sodium chloride content diet (8 %) (for 42 days) then atropine (1 mg/kg) then ambient air (between 0 and 0.1 hours) |
Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. |
arterial blood pressure trait |
not specified |
86.0 days
| 4 |
sampling once per minute |
|
128.0 |
mmHg |
1.5 |
3.0 |
intra-aortic thoracic radiotelemetry |
|
0.0 |
|
|
|
|
|
103198 |
2787 |
| SR/Jr |
mean arterial blood pressure |
controlled sodium chloride content diet (0.3 %) (for 42 days) then controlled sodium chloride content diet (8 %) (for 42 days) then atropine (1 mg/kg) then 10% CO2, 20% O2, 70% N2 (between 0 and 0.4 hours) then ambient air (between 0 and 0.1 hours) |
Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. |
arterial blood pressure trait |
not specified |
86.0 days
| 5 |
sampling once per minute |
|
115.0 |
mmHg |
2.24 |
5.0 |
intra-aortic thoracic radiotelemetry |
|
0.0 |
|
|
|
|
|
103205 |
2787 |
| SR/JrHsd |
body weight |
controlled sodium chloride content diet (0.4 %) (for 14 days) then bilateral ovariectomy then 17 beta-estradiol (10 ug/d) (for 14 days) |
Zheng W, et al., Am J Physiol Heart Circ Physiol. 2008 Apr;294(4):H1508-13. doi: 10.1152/ajpheart.01322.2007. Epub 2008 Feb 1. |
body mass |
female |
days
| |
|
|
200.0 |
g |
2.5 |
|
body weighing method |
|
0.0 |
|
|
|
|
|
102187 |
2681 |
| SS/JrHsd |
body weight |
controlled sodium chloride content diet (0.4 %) (for 14 days) then sham surgical control condition then peanut oil (0.2 ml) (for 14 days) |
Zheng W, et al., Am J Physiol Heart Circ Physiol. 2008 Apr;294(4):H1508-13. doi: 10.1152/ajpheart.01322.2007. Epub 2008 Feb 1. |
body mass |
female |
days
| |
|
|
252.0 |
g |
3.8 |
|
body weighing method |
|
0.0 |
|
|
|
|
|
102189 |
2681 |
| SS/JrHsd |
body weight |
controlled sodium chloride content diet (0.4 %) (for 14 days) then bilateral ovariectomy then peanut oil (0.2 ml) (for 14 days) |
Zheng W, et al., Am J Physiol Heart Circ Physiol. 2008 Apr;294(4):H1508-13. doi: 10.1152/ajpheart.01322.2007. Epub 2008 Feb 1. |
body mass |
female |
days
| |
|
|
294.0 |
g |
4.0 |
|
body weighing method |
|
0.0 |
|
|
|
|
|
102191 |
2681 |
| SR/JrHsd |
single kidney wet weight |
controlled sodium chloride content diet (0.4 %) (for 14 days) then sham surgical control condition then peanut oil (0.2 ml) (for 14 days) |
Zheng W, et al., Am J Physiol Heart Circ Physiol. 2008 Apr;294(4):H1508-13. doi: 10.1152/ajpheart.01322.2007. Epub 2008 Feb 1. |
kidney mass |
female |
days
| |
|
|
0.86 |
g |
0.02 |
|
post excision weight measurement |
|
0.0 |
|
|
|
|
|
102195 |
2681 |
| SR/JrHsd |
single kidney wet weight |
controlled sodium chloride content diet (4 %) (for 14 days) then bilateral ovariectomy then peanut oil (0.2 ml) (for 14 days) |
Zheng W, et al., Am J Physiol Heart Circ Physiol. 2008 Apr;294(4):H1508-13. doi: 10.1152/ajpheart.01322.2007. Epub 2008 Feb 1. |
kidney mass |
female |
days
| |
|
|
1.02 |
g |
0.03 |
|
post excision weight measurement |
|
0.0 |
|
|
|
|
|
102198 |
2681 |
| SS/JrHsd |
single kidney wet weight |
controlled sodium chloride content diet (4 %) (for 14 days) then sham surgical control condition then peanut oil (0.2 ml) (for 14 days) |
Zheng W, et al., Am J Physiol Heart Circ Physiol. 2008 Apr;294(4):H1508-13. doi: 10.1152/ajpheart.01322.2007. Epub 2008 Feb 1. |
kidney mass |
female |
days
| |
|
|
1.26 |
g |
0.09 |
|
post excision weight measurement |
|
0.0 |
|
|
|
|
|
102202 |
2681 |
| SS/JrHsd |
single kidney wet weight |
controlled sodium chloride content diet (4 %) (for 14 days) then bilateral ovariectomy then 17 beta-estradiol (10 ug/d) (for 14 days) |
Zheng W, et al., Am J Physiol Heart Circ Physiol. 2008 Apr;294(4):H1508-13. doi: 10.1152/ajpheart.01322.2007. Epub 2008 Feb 1. |
kidney mass |
female |
days
| |
|
|
1.71 |
g |
0.08 |
|
post excision weight measurement |
|
0.0 |
|
|
|
|
|
102206 |
2681 |
| SS/JrHsd |
mean arterial blood pressure |
controlled sodium chloride content diet (0.4 %) (for 14 days) then bilateral ovariectomy then peanut oil (0.2 ml) (for 14 days) |
Zheng W, et al., Am J Physiol Heart Circ Physiol. 2008 Apr;294(4):H1508-13. doi: 10.1152/ajpheart.01322.2007. Epub 2008 Feb 1. |
arterial blood pressure trait |
female |
days
| |
|
|
135.0 |
mmHg |
4.0 |
|
vascular fluid filled catheter |
|
0.0 |
|
|
|
|
|
102211 |
2681 |
| SS/JrHsd |
glomerular filtration rate to kidney weight ratio |
controlled sodium chloride content diet (0.4 %) (for 14 days) then sham surgical control condition then peanut oil (0.2 ml) (for 14 days) |
Zheng W, et al., Am J Physiol Heart Circ Physiol. 2008 Apr;294(4):H1508-13. doi: 10.1152/ajpheart.01322.2007. Epub 2008 Feb 1. |
glomerular filtration trait |
female |
days
| |
|
|
2.46 |
ml/min/g |
0.06 |
|
inulin analysis by liquid phase colorimetry |
|
0.0 |
|
|
|
|
|
102216 |
2681 |
| SS/JrHsd |
glomerular filtration rate to kidney weight ratio |
controlled sodium chloride content diet (0.4 %) (for 14 days) then bilateral ovariectomy then peanut oil (0.2 ml) (for 14 days) |
Zheng W, et al., Am J Physiol Heart Circ Physiol. 2008 Apr;294(4):H1508-13. doi: 10.1152/ajpheart.01322.2007. Epub 2008 Feb 1. |
glomerular filtration trait |
female |
days
| |
|
|
2.54 |
ml/min/g |
0.13 |
|
inulin analysis by liquid phase colorimetry |
|
0.0 |
|
|
|
|
|
102217 |
2681 |
| SS/NEisSlc |
heart rate |
controlled sodium chloride content diet (8 %) (for 21 days) then 0.9% sodium chloride solution (for 21 days) |
Yoshihara F, et al., Regul Pept. 2005 May 15;128(1):7-13. |
heart pumping trait |
male |
77.0 days
| 14 |
|
|
355.0 |
beats/min |
10.16 |
38.0 |
tail cuff plethysmography |
|
0.0 |
|
|
|
|
|
102457 |
2689 |
| SR/NEisSlc |
heart left ventricle plus septum weight to body weight ratio |
controlled sodium chloride content diet (8 %) (for 21 days) then 0.9% sodium chloride solution (for 21 days) |
Yoshihara F, et al., Regul Pept. 2005 May 15;128(1):7-13. |
heart left ventricle mass |
male |
77.0 days
| 19 |
|
|
1.9 |
mg/g |
0.03 |
0.13 |
post excision weight measurement |
|
0.0 |
|
|
|
heart left ventricle plus septum weight to body weight ratio (CMO:0003869) |
|
102459 |
2689 |
| SS/NEisSlc |
heart rate |
controlled sodium chloride content diet (8 %) (for 21 days) then adrenomedulin (400 ng/hr) (for 21 days) |
Yoshihara F, et al., Regul Pept. 2005 May 15;128(1):7-13. |
heart pumping trait |
male |
77.0 days
| 14 |
|
|
332.0 |
beats/min |
9.35 |
35.0 |
tail cuff plethysmography |
|
0.0 |
|
|
|
|
|
102458 |
2689 |
| SS/NEisSlc |
systolic blood pressure |
controlled sodium chloride content diet (8 %) (for 21 days) then 0.9% sodium chloride solution (for 21 days) |
Yoshihara F, et al., Regul Pept. 2005 May 15;128(1):7-13. |
arterial blood pressure trait |
male |
77.0 days
| 14 |
mean of 3 samples of undefined duration |
serial mean |
173.0 |
mmHg |
2.67 |
10.0 |
tail cuff plethysmography |
|
0.0 |
|
|
|
|
|
102466 |
2689 |
| SS/NEisSlc |
urine sodium excretion rate |
controlled sodium chloride content diet (8 %) (for 21 days) then 0.9% sodium chloride solution (for 21 days) |
Yoshihara F, et al., Regul Pept. 2005 May 15;128(1):7-13. |
urine sodium amount |
male |
77.0 days
| 14 |
|
|
1.4 |
mEq/d |
0.13 |
0.5 |
automated urine sodium analysis |
|
0.0 |
|
|
|
|
|
102469 |
2689 |
| SR/NEisSlc |
body weight |
controlled sodium chloride content diet (0.3 %) (for 42 days) then controlled sodium chloride content diet (8 %) (for 35 days) |
Horinaka S, et al., Int J Cardiol. 2003 Sep;91(1):25-35. |
body mass |
male |
77.0 days
| 10 |
|
|
356.0 |
g |
3.48 |
11.0 |
body weighing method |
|
0.0 |
|
|
|
|
|
102480 |
2690 |
| SS/NEisSlc |
body weight |
controlled sodium chloride content diet (0.3 %) (for 42 days) then controlled sodium chloride content diet (8 %) (for 35 days) |
Horinaka S, et al., Int J Cardiol. 2003 Sep;91(1):25-35. |
body mass |
male |
77.0 days
| 10 |
|
|
344.0 |
g |
8.22 |
26.0 |
body weighing method |
|
0.0 |
|
|
|
|
|
102482 |
2690 |
| SR/NEisSlc |
heart left ventricle weight |
controlled sodium chloride content diet (0.3 %) (for 42 days) then controlled sodium chloride content diet (8 %) (for 84 days) |
Horinaka S, et al., Int J Cardiol. 2003 Sep;91(1):25-35. |
heart left ventricle mass |
male |
126.0 days
| 10 |
|
|
0.94 |
g |
0.0 |
0.0 |
post excision weight measurement |
|
0.0 |
|
|
|
|
|
102485 |
2690 |
| SS/NEisSlc |
heart left ventricle weight |
controlled sodium chloride content diet (0.3 %) (for 42 days) then controlled sodium chloride content diet (8 %) (for 35 days) |
Horinaka S, et al., Int J Cardiol. 2003 Sep;91(1):25-35. |
heart left ventricle mass |
male |
77.0 days
| 10 |
|
|
1.15 |
g |
0.0 |
0.0 |
post excision weight measurement |
|
0.0 |
|
|
|
|
|
102486 |
2690 |
| SS/NEisSlc |
heart left ventricle weight to body weight ratio |
controlled sodium chloride content diet (0.3 %) (for 42 days) then controlled sodium chloride content diet (8 %) (for 35 days) |
Horinaka S, et al., Int J Cardiol. 2003 Sep;91(1):25-35. |
heart left ventricle mass |
male |
77.0 days
| 10 |
|
|
3.35 |
mg/g |
0.12 |
0.38 |
post excision weight measurement |
|
0.0 |
|
|
|
|
|
102490 |
2690 |
| SS/NEisSlc |
heart left ventricle weight to body weight ratio |
controlled sodium chloride content diet (0.3 %) (for 42 days) then controlled sodium chloride content diet (8 %) (for 84 days) |
Horinaka S, et al., Int J Cardiol. 2003 Sep;91(1):25-35. |
heart left ventricle mass |
male |
126.0 days
| 10 |
|
|
4.39 |
mg/g |
0.08 |
0.24 |
post excision weight measurement |
|
0.0 |
|
|
|
|
|
102491 |
2690 |
| SR/NEisSlc |
heart rate |
controlled sodium chloride content diet (0.3 %) (for 42 days) then controlled sodium chloride content diet (8 %) (for 35 days) |
Horinaka S, et al., Int J Cardiol. 2003 Sep;91(1):25-35. |
heart pumping trait |
male |
77.0 days
| 10 |
|
|
464.0 |
beats/min |
8.54 |
27.0 |
tail cuff plethysmography |
|
0.0 |
|
|
|
|
|
102496 |
2690 |
| SS/NEisSlc |
left ventricular systolic blood pressure |
controlled sodium chloride content diet (0.3 %) (for 42 days) then controlled sodium chloride content diet (8 %) (for 84 days) then pentobarbital (20 mg/kg) |
Horinaka S, et al., Int J Cardiol. 2003 Sep;91(1):25-35. |
heart left ventricular blood pressure trait |
male |
126.0 days
| 10 |
|
|
148.0 |
mmHg |
6.96 |
22.0 |
volume pressure recording |
|
0.0 |
|
|
|
|
|
102503 |
2690 |
| SS/NEisSlc |
heart rate |
controlled sodium chloride content diet (0.3 %) (for 42 days) then controlled sodium chloride content diet (8 %) (for 84 days) then pentobarbital (20 mg/kg) |
Horinaka S, et al., Int J Cardiol. 2003 Sep;91(1):25-35. |
heart pumping trait |
male |
126.0 days
| 10 |
|
|
383.0 |
beats/min |
15.18 |
48.0 |
tail cuff plethysmography |
|
0.0 |
|
|
|
|
|
102505 |
2690 |
| SS-Plod1em1Mcwi-/- |
systolic blood pressure |
controlled sodium chloride content diet (0.4 %) (between 56 and 63 days) then controlled sodium chloride content diet (4 %) (for 10 days) |
Flister MJ, et al., Genome Res. 2013 Dec;23(12):1996-2002. doi: 10.1101/gr.160283.113. Epub 2013 Sep 4. |
arterial blood pressure trait |
male |
58.0 days-67.0 days |
|
|
serial mean |
165.0 |
mmHg |
4.0 |
|
intra-aortic abdominal radiotelemetry |
|
32400.0 |
|
|
|
|
|
98411 |
2059 |
| SS/NEisSlc |
left ventricular end-diastolic blood pressure |
controlled sodium chloride content diet (0.3 %) (for 42 days) then controlled sodium chloride content diet (8 %) (for 84 days) then pentobarbital (20 mg/kg) |
Horinaka S, et al., Int J Cardiol. 2003 Sep;91(1):25-35. |
heart left ventricular blood pressure trait |
male |
126.0 days
| 10 |
|
|
6.3 |
mmHg |
1.14 |
3.6 |
volume pressure recording |
|
0.0 |
|
|
|
|
|
102511 |
2690 |
| SR/NEisSlc |
heart left ventricle end-systolic elastance |
controlled sodium chloride content diet (0.3 %) (for 42 days) then controlled sodium chloride content diet (8 %) (for 35 days) then pentobarbital (20 mg/kg) |
Horinaka S, et al., Int J Cardiol. 2003 Sep;91(1):25-35. |
heart left ventricular blood pressure trait |
male |
77.0 days
| 10 |
|
|
2404.0 |
mmHg/ml |
78.42 |
248.0 |
volume pressure recording |
|
0.0 |
|
|
|
|
|
102520 |
2690 |
| SS/NEisSlc |
heart left ventricle end-diastolic elastance |
controlled sodium chloride content diet (0.3 %) (for 42 days) then controlled sodium chloride content diet (8 %) (for 35 days) then pentobarbital (20 mg/kg) |
Horinaka S, et al., Int J Cardiol. 2003 Sep;91(1):25-35. |
heart left ventricular blood pressure trait |
male |
77.0 days
| 10 |
|
|
58.0 |
mmHg/ml |
6.64 |
21.0 |
volume pressure recording |
|
0.0 |
|
|
|
|
|
102530 |
2690 |
| SS.BN-(D13Hmgc354-D13Rat32)/Mcwi |
urine albumin excretion rate |
controlled sodium chloride content diet (0.4 %) (between 46 and 50.8 days) then controlled sodium chloride content diet (8 %) (for 13.4 days) |
Cowley AW, et al., Physiol Genomics. 2014 Jun 1;46(11):398-410. doi: 10.1152/physiolgenomics.00179.2013. Epub 2014 Apr 8. |
urine albumin amount |
male |
60.0 days-67.0 days |
16 |
|
|
150.0 |
mg/d |
27.0 |
108.0 |
urine microalbumin analysis |
|
0.0 |
|
|
|
strain 26-J |
|
98635 |
2098 |
| LH/MavRrrcAek |
systolic blood pressure |
standard rat chow (for 98 days) then controlled sodium chloride content diet (4 %) (for 21 days) |
Wang J, et al., Circ Cardiovasc Genet. 2015 Apr;8(2):316-26. doi: 10.1161/CIRCGENETICS.114.000520. Epub 2015 Jan 8. |
arterial blood pressure trait |
male |
119.0 days
| 9 |
mean of 15 sec every 5 min for 72 hours |
serial mean |
161.2 |
mmHg |
2.1 |
6.3 |
intra-aortic abdominal radiotelemetry via femoral cannulation |
|
0.0 |
|
|
|
|
|
102609 |
3014 |
| LH/MavRrrcAek |
diastolic blood pressure |
standard rat chow (for 98 days) then controlled sodium chloride content diet (4 %) (for 21 days) |
Wang J, et al., Circ Cardiovasc Genet. 2015 Apr;8(2):316-26. doi: 10.1161/CIRCGENETICS.114.000520. Epub 2015 Jan 8. |
arterial blood pressure trait |
male |
119.0 days
| 9 |
mean of 15 sec every 5 min for 72 hours |
serial mean |
113.9 |
mmHg |
1.6 |
4.8 |
intra-aortic abdominal radiotelemetry via femoral cannulation |
|
0.0 |
|
|
|
|
|
102611 |
3014 |
| LH/MavRrrcAek |
heart rate |
standard rat chow (for 98 days) then controlled sodium chloride content diet (4 %) (for 21 days) |
Wang J, et al., Circ Cardiovasc Genet. 2015 Apr;8(2):316-26. doi: 10.1161/CIRCGENETICS.114.000520. Epub 2015 Jan 8. |
heart pumping trait |
male |
119.0 days
| 9 |
|
|
319.2 |
beats/min |
1.8 |
5.4 |
intra-aortic abdominal radiotelemetry via femoral cannulation |
|
0.0 |
|
|
|
|
|
102615 |
3014 |
| LH/MavRrrcAek |
combined renal and gonadal fat pad weight |
standard rat chow (for 98 days) then controlled sodium chloride content diet (4 %) (for 21 days) |
Wang J, et al., Circ Cardiovasc Genet. 2015 Apr;8(2):316-26. doi: 10.1161/CIRCGENETICS.114.000520. Epub 2015 Jan 8. |
fat pad morphology trait |
male |
126.0 days
| 9 |
|
|
1.43 |
g |
0.09 |
0.27 |
post excision weight measurement |
|
0.0 |
|
|
|
combined renal and gonadal fat pad weight (CMO:0003886) |
|
102619 |
3014 |
| LN/MavRrrcAek |
plasma triglyceride level |
standard rat chow (for 98 days) then controlled sodium chloride content diet (4 %) (for 14 days) |
Wang J, et al., Circ Cardiovasc Genet. 2015 Apr;8(2):316-26. doi: 10.1161/CIRCGENETICS.114.000520. Epub 2015 Jan 8. |
blood triglyceride amount |
male |
112.0 days
| 14 |
|
|
0.4 |
mmol/l |
0.05 |
0.19 |
plasma triglyceride analysis |
|
0.0 |
|
|
|
|
|
102628 |
3014 |
| LH/MavRrrcAek |
plasma total cholesterol level |
standard rat chow (for 98 days) then controlled sodium chloride content diet (4 %) (for 14 days) |
Wang J, et al., Circ Cardiovasc Genet. 2015 Apr;8(2):316-26. doi: 10.1161/CIRCGENETICS.114.000520. Epub 2015 Jan 8. |
blood cholesterol amount |
male |
112.0 days
| 9 |
|
|
62.55 |
mg/dl |
7.72 |
23.17 |
plasma total cholesterol measurement test |
|
0.0 |
|
|
|
|
|
102633 |
3014 |
| SS/JrHsdMcwi |
heart rate |
controlled sodium chloride content diet (0.4 %) (between 23 and 32 days) then controlled sodium chloride content diet (8 %) (for 14 days) |
Cowley AW Jr, et al., Physiol Genomics. 2016 Jan;48(1):62-72. doi: 10.1152/physiolgenomics.00097.2015. Epub 2015 Nov 3. |
heart pumping trait |
male |
58.0 days-67.0 days |
14 |
|
serial mean |
387.0 |
beats/min |
6.0 |
22.45 |
intra-aortic thoracic radiotelemetry via carotid cannulation |
|
10800.0 |
|
|
carotid a. to thoracic aorta implant |
|
|
98521 |
2079 |
| SS.BN-(D13Rat25-rs106935835)/Mcwi |
mean arterial blood pressure |
controlled sodium chloride content diet (0.4 %) (for 70 days) then controlled sodium chloride content diet (8 %) (for 21 days) |
Hoffman MJ, et al., Hypertension. 2013 Sep;62(3):557-63. doi: 10.1161/HYPERTENSIONAHA.113.01708. Epub 2013 Jul 1. |
arterial blood pressure trait |
female |
91.0 days
| 8 |
|
serial mean |
186.0 |
mmHg |
3.0 |
8.49 |
intra-aortic abdominal radiotelemetry via femoral cannulation |
|
10800.0 |
|
|
|
strain 9E |
|
98706 |
2141 |
| SS/Jr |
single kidney wet weight to body weight ratio |
controlled sodium chloride content diet (8 %) (for 35 days) |
Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. |
kidney mass |
male |
63.0 days
| 10 |
|
|
8.65 |
g/kg |
0.17 |
0.54 |
post excision weight measurement |
|
0.0 |
|
|
|
|
|
103245 |
2802 |
| SS/Jr |
mean arterial blood pressure |
controlled sodium chloride content diet (0.3 %) (for 35 days) |
Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. |
arterial blood pressure trait |
male |
63.0 days
| 15 |
|
|
131.0 |
mmHg |
3.0 |
11.62 |
vascular transducer tipped catheter |
|
0.0 |
|
|
|
|
|
103252 |
2802 |
| SR/Jr |
mean arterial blood pressure |
controlled sodium chloride content diet (8 %) (for 35 days) |
Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. |
arterial blood pressure trait |
male |
63.0 days
| 13 |
|
|
107.0 |
mmHg |
4.0 |
14.42 |
vascular transducer tipped catheter |
|
0.0 |
|
|
|
|
|
103251 |
2802 |
| SR/Jr |
diastolic blood pressure |
controlled sodium chloride content diet (8 %) (for 35 days) |
Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. |
arterial blood pressure trait |
male |
63.0 days
| 13 |
|
|
85.0 |
mmHg |
4.0 |
14.42 |
vascular transducer tipped catheter |
|
0.0 |
|
|
|
|
|
103255 |
2802 |
| SS/Jr |
diastolic blood pressure |
controlled sodium chloride content diet (0.3 %) (for 35 days) |
Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. |
arterial blood pressure trait |
male |
63.0 days
| 15 |
|
|
108.0 |
mmHg |
3.0 |
11.62 |
vascular transducer tipped catheter |
|
0.0 |
|
|
|
|
|
103256 |
2802 |
| SR/Jr |
plasma triglyceride level |
controlled sodium chloride content diet (8 %) (for 35 days) |
Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. |
blood triglyceride amount |
male |
63.0 days
| 13 |
|
|
0.61 |
mmol/l |
0.16 |
0.58 |
plasma triglyceride analysis |
|
0.0 |
|
|
|
|
|
103259 |
2802 |
| SS/Jr |
plasma triglyceride level |
controlled sodium chloride content diet (8 %) (for 35 days) |
Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. |
blood triglyceride amount |
male |
63.0 days
| 10 |
|
|
1.49 |
mmol/l |
0.29 |
0.92 |
plasma triglyceride analysis |
|
0.0 |
|
|
|
|
|
103261 |
2802 |
| SS/Jr |
plasma total cholesterol level |
controlled sodium chloride content diet (0.3 %) (for 35 days) |
Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. |
blood cholesterol amount |
male |
63.0 days
| 15 |
|
|
79.15 |
mg/dl |
4.63 |
17.94 |
plasma total cholesterol measurement test |
|
0.0 |
|
|
|
|
|
103264 |
2802 |
| SR/Jr |
hematocrit |
controlled sodium chloride content diet (0.3 %) (for 35 days) |
Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. |
erythrocyte quantity |
male |
63.0 days
| 16 |
|
|
45.8 |
% |
0.4 |
1.6 |
hematocrit analysis |
|
0.0 |
|
|
|
|
|
103266 |
2802 |
| SS/Jr |
red blood cell sodium level |
controlled sodium chloride content diet (8 %) (for 35 days) |
Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. |
erythrocyte sodium amount |
male |
63.0 days
| 10 |
|
|
3.77 |
mmol/l |
0.04 |
0.13 |
ex vivo blood analysis |
|
0.0 |
|
|
|
|
|
103277 |
2802 |
| SS-Renem1Mcwi+/+ |
serum bicarbonate level |
controlled sodium chloride content diet (0.4 %) (for 42 days) |
Moreno C, et al., Hypertension. 2011 Mar;57(3):614-9. doi: 10.1161/HYPERTENSIONAHA.110.163840. Epub 2011 Jan 17. |
blood bicarbonate amount |
male |
63.0 days
| 5 |
|
|
27.6 |
mmol/l |
0.58 |
1.3 |
automated serum bicarbonate test |
|
0.0 |
|
|
|
|
|
98367 |
2038 |
| SS-Nppbem2Mcwi+/+ |
ejection fraction |
controlled sodium chloride content diet (for 21 days) |
Holditch SJ, et al., Hypertension. 2015 Jul;66(1):199-210. doi: 10.1161/HYPERTENSIONAHA.115.05610. Epub 2015 May 11. |
cardiac output trait |
male |
98.0 days
| 4 |
|
|
77.3 |
% |
3.09 |
6.18 |
echocardiography |
|
0.0 |
|
|
|
|
|
99722 |
2319 |
| SR/Hsd |
plasma urotensin II level |
controlled sodium chloride content diet (8 %) (for 42 days) |
Wu F, et al., Int J Hypertens. 2016;2016:9146870. doi: 10.1155/2016/9146870. Epub 2016 Dec 19. |
blood urotensin II amount |
male |
91.0 days
| 8 |
|
|
60.0 |
pg/ml |
2.26 |
6.4 |
radioimmunoassay |
|
0.0 |
|
|
|
|
|
102277 |
2683 |
| SS/NEisSlc |
body weight |
controlled sodium chloride content diet (8 %) (for 7 days) |
Yoshihara F, et al., Regul Pept. 2005 May 15;128(1):7-13. |
body mass |
male |
63.0 days
| 8 |
|
|
292.0 |
g |
3.18 |
9.0 |
body weighing method |
|
0.0 |
|
|
|
|
|
102406 |
2689 |
| SR/NEisSlc |
heart rate |
controlled sodium chloride content diet (8 %) (for 14 days) |
Yoshihara F, et al., Regul Pept. 2005 May 15;128(1):7-13. |
heart pumping trait |
male |
70.0 days
| 8 |
|
|
396.0 |
beats/min |
12.73 |
36.0 |
tail cuff plethysmography |
|
0.0 |
|
|
|
|
|
102413 |
2689 |
| SS/NEisSlc |
heart rate |
controlled sodium chloride content diet (8 %) (for 7 days) |
Yoshihara F, et al., Regul Pept. 2005 May 15;128(1):7-13. |
heart pumping trait |
male |
63.0 days
| 8 |
|
|
398.0 |
beats/min |
13.08 |
37.0 |
tail cuff plethysmography |
|
0.0 |
|
|
|
|
|
102412 |
2689 |
| SS/NEisSlc |
heart rate |
controlled sodium chloride content diet (8 %) (for 21 days) |
Yoshihara F, et al., Regul Pept. 2005 May 15;128(1):7-13. |
heart pumping trait |
male |
77.0 days
| 8 |
|
|
399.0 |
beats/min |
8.84 |
25.0 |
tail cuff plethysmography |
|
0.0 |
|
|
|
|
|
102416 |
2689 |
| SR/NEisSlc |
heart left ventricle plus septum weight to body weight ratio |
controlled sodium chloride content diet (8 %) (for 7 days) |
Yoshihara F, et al., Regul Pept. 2005 May 15;128(1):7-13. |
heart left ventricle mass |
male |
63.0 days
| 7 |
|
|
2.06 |
mg/g |
0.06 |
0.15 |
post excision weight measurement |
|
0.0 |
|
|
|
heart left ventricle plus septum weight to body weight ratio (CMO:0003869) |
|
102417 |
2689 |
| SR/NEisSlc |
urine sodium excretion rate |
controlled sodium chloride content diet (8 %) (for 7 days) |
Yoshihara F, et al., Regul Pept. 2005 May 15;128(1):7-13. |
urine sodium amount |
male |
63.0 days
| 7 |
|
|
2.1 |
mEq/d |
0.38 |
1.0 |
automated urine sodium analysis |
|
0.0 |
|
|
|
|
|
102435 |
2689 |
| SS/NEisSlc |
kidney cortical adrenomedullin level |
controlled sodium chloride content diet (8 %) (for 7 days) |
Yoshihara F, et al., Regul Pept. 2005 May 15;128(1):7-13. |
kidney adrenomedullin amount |
male |
63.0 days
| 8 |
|
|
0.62 |
fmol/mg |
0.02 |
0.05 |
radioimmunoassay |
|
0.0 |
|
|
|
|
|
102442 |
2689 |
| SR/NEisSlc |
urine sodium excretion rate |
controlled sodium chloride content diet (8 %) (for 21 days) |
Yoshihara F, et al., Regul Pept. 2005 May 15;128(1):7-13. |
urine sodium amount |
male |
77.0 days
| 7 |
|
|
2.7 |
mEq/d |
0.49 |
1.3 |
automated urine sodium analysis |
|
0.0 |
|
|
|
|
|
102439 |
2689 |
| SS/NEisSlc |
kidney cortical adrenomedullin level |
controlled sodium chloride content diet (8 %) (for 21 days) |
Yoshihara F, et al., Regul Pept. 2005 May 15;128(1):7-13. |
kidney adrenomedullin amount |
male |
77.0 days
| 8 |
|
|
0.74 |
fmol/mg |
0.02 |
0.06 |
radioimmunoassay |
|
0.0 |
|
|
|
|
|
102446 |
2689 |
| SS/NEisSlc |
kidney medullary adrenomedullin level |
controlled sodium chloride content diet (8 %) (for 14 days) |
Yoshihara F, et al., Regul Pept. 2005 May 15;128(1):7-13. |
kidney adrenomedullin amount |
male |
70.0 days
| 7 |
|
|
0.31 |
fmol/mg |
0.01 |
0.02 |
radioimmunoassay |
|
0.0 |
|
|
|
|
|
102450 |
2689 |
| SS/NEisSlc |
urine total protein excretion rate to body weight ratio |
controlled sodium chloride content diet (8 %) (for 14 days) then 0.9% sodium chloride solution (for 14 days) |
Yoshihara F, et al., Regul Pept. 2005 May 15;128(1):7-13. |
total urine protein amount |
male |
70.0 days
| 14 |
|
|
6.5 |
mg/d/100 g |
0.67 |
2.5 |
urine protein analysis |
|
0.0 |
|
|
|
|
|
102475 |
2689 |
| SR/NEisSlc |
urine total protein excretion rate to body weight ratio |
controlled sodium chloride content diet (8 %) (for 14 days) then 0.9% sodium chloride solution (for 14 days) |
Yoshihara F, et al., Regul Pept. 2005 May 15;128(1):7-13. |
total urine protein amount |
male |
70.0 days
| 19 |
|
|
3.2 |
mg/d/100 g |
0.21 |
0.9 |
urine protein analysis |
|
0.0 |
|
|
|
|
|
102474 |
2689 |
| SS/NEisSlc |
urine total protein excretion rate to body weight ratio |
controlled sodium chloride content diet (8 %) (for 21 days) then adrenomedulin (400 ng/hr) (for 21 days) |
Yoshihara F, et al., Regul Pept. 2005 May 15;128(1):7-13. |
total urine protein amount |
male |
77.0 days
| 14 |
|
|
5.7 |
mg/d/100 g |
0.43 |
1.6 |
urine protein analysis |
|
0.0 |
|
|
|
|
|
102479 |
2689 |
| SS/Hsd |
urine sodium excretion rate |
controlled sodium chloride content diet (0.4 %) (between 56 and 63 days) then controlled sodium chloride content diet (4 %) (for 12 days) |
Flister MJ, et al., Genome Res. 2013 Dec;23(12):1996-2002. doi: 10.1101/gr.160283.113. Epub 2013 Sep 4. |
urine sodium amount |
male |
60.0 days-69.0 days |
|
|
|
10.0 |
mEq/d |
0.6 |
|
urine electrolyte analysis |
|
0.0 |
|
|
|
|
|
98450 |
2059 |
| SS/Jr |
heart weight to body weight ratio |
controlled sodium chloride content diet (0.3 %) (for 35 days) |
Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. |
heart mass |
male |
63.0 days
| 15 |
|
|
2.59 |
g/kg |
0.04 |
0.15 |
post excision weight measurement |
|
0.0 |
|
|
|
|
|
103240 |
2802 |
| SS-Nppaem4Mcwi-/- |
urine sodium excretion rate |
controlled sodium chloride content diet (0.4 %) (between 56 and 63 days) then controlled sodium chloride content diet (4 %) (for 12 days) |
Flister MJ, et al., Genome Res. 2013 Dec;23(12):1996-2002. doi: 10.1101/gr.160283.113. Epub 2013 Sep 4. |
urine sodium amount |
male |
60.0 days-69.0 days |
|
|
|
8.6 |
mEq/d |
1.0 |
|
urine electrolyte analysis |
|
0.0 |
|
|
|
|
|
98446 |
2059 |
| SD-Nfe2l2em1Mcwi+/+ |
mean arterial blood pressure |
controlled sodium chloride content diet (0.4 %) (between 70 and 84 days) then controlled sodium chloride content diet (4 %) (for 3 days) then angiotensin II (100 ng/kg/min) (for 3 days) |
Priestley JR, et al., Am J Physiol Heart Circ Physiol. 2016 Feb 15;310(4):H478-87. doi: 10.1152/ajpheart.00586.2015. Epub 2015 Dec 4. |
arterial blood pressure trait |
male |
62.0 days-76.0 days |
3 |
|
|
95.0 |
mmHg |
4.3 |
7.45 |
vascular fluid filled catheter |
|
0.0 |
|
|
|
|
|
100741 |
2520 |
| SD-Nfe2l2em1Mcwi+/+ |
resting tone of middle cerebral artery |
controlled sodium chloride content diet (0.4 %) (between 70 and 84 days) then controlled sodium chloride content diet (4 %) (for 3 days) then 0.9% sodium chloride solution (for 3 days) |
Priestley JR, et al., Am J Physiol Heart Circ Physiol. 2016 Feb 15;310(4):H478-87. doi: 10.1152/ajpheart.00586.2015. Epub 2015 Dec 4. |
cerebral artery size trait |
male |
62.0 days-76.0 days |
5 |
[(Dmax - Drest) /Dmax] x 100 |
|
41.4 |
% |
4.47 |
10.0 |
isolated body part method |
|
0.0 |
|
|
|
tone |
|
100757 |
2520 |
| SS/JrHsd |
adrenal angiotensin II type 1 receptor density |
controlled sodium chloride content diet (4 %) (for 14 days) then bilateral ovariectomy then peanut oil (0.2 ml) (for 14 days) |
Zheng W, et al., Am J Physiol Heart Circ Physiol. 2008 Apr;294(4):H1508-13. doi: 10.1152/ajpheart.01322.2007. Epub 2008 Feb 1. |
adrenal gland molecular composition trait |
female |
days
| |
|
|
138.0 |
fmol/mg |
10.0 |
|
radioimmunoassay |
|
0.0 |
|
|
|
|
|
102230 |
2681 |
| SS/JrHsd |
adrenal angiotensin II type 1 receptor density |
controlled sodium chloride content diet (0.4 %) (for 14 days) then bilateral ovariectomy then 17 beta-estradiol (10 ug/d) (for 14 days) |
Zheng W, et al., Am J Physiol Heart Circ Physiol. 2008 Apr;294(4):H1508-13. doi: 10.1152/ajpheart.01322.2007. Epub 2008 Feb 1. |
adrenal gland molecular composition trait |
female |
days
| |
|
|
82.7 |
fmol/mg |
5.8 |
|
radioimmunoassay |
|
0.0 |
|
|
|
|
|
102231 |
2681 |
| SS.BN-(D13Got42-D13Got45)/Mcwi |
diastolic blood pressure |
controlled sodium chloride content diet (0.4 %) (between 46 and 50.8 days) then controlled sodium chloride content diet (8 %) (for 13.4 days) |
Cowley AW, et al., Physiol Genomics. 2014 Jun 1;46(11):398-410. doi: 10.1152/physiolgenomics.00179.2013. Epub 2014 Apr 8. |
arterial blood pressure trait |
male |
60.0 days-67.0 days |
13 |
|
serial mean |
153.0 |
mmHg |
7.0 |
25.24 |
intra-aortic thoracic radiotelemetry via carotid cannulation |
|
10800.0 |
|
|
intra-carotid radiotelemetry |
strain 26-B |
|
98583 |
2098 |
| SD-Nfe2l2em1Mcwi+/+ |
body weight |
controlled sodium chloride content diet (0.4 %) (between 70 and 84 days) then controlled sodium chloride content diet (4 %) (for 3 days) then 0.9% sodium chloride solution (for 3 days) |
Priestley JR, et al., Am J Physiol Heart Circ Physiol. 2016 Feb 15;310(4):H478-87. doi: 10.1152/ajpheart.00586.2015. Epub 2015 Dec 4. |
body mass |
male |
62.0 days-76.0 days |
8 |
|
|
281.0 |
g |
17.7 |
50.06 |
body weighing method |
|
0.0 |
|
|
|
|
|
100733 |
2520 |
| SS-Renem1Mcwi+/- |
urine creatinine excretion rate |
controlled sodium chloride content diet (0.4 %) (for 35 days) |
Moreno C, et al., Hypertension. 2011 Mar;57(3):614-9. doi: 10.1161/HYPERTENSIONAHA.110.163840. Epub 2011 Jan 17. |
urine creatinine amount |
female |
56.0 days
| 9 |
|
|
5.4 |
mg/d |
0.18 |
0.54 |
urine creatinine analysis |
|
0.0 |
|
|
|
|
|
98335 |
2038 |
| SS-Shc1em5Mcwi |
renal afferent arteriole diameter |
controlled sodium chloride content diet (1 %) (between 70 and 91 days) then controlled ex vivo artery perfusion pressure (60 mmHg) (for 0.1 hours) |
Miller B, et al., J Clin Invest. 2016 Jul 1;126(7):2533-46. doi: 10.1172/JCI75079. Epub 2016 Jun 6. |
kidney arteriole morphology trait |
not specified |
91.0 days-133.0 days |
5 |
|
|
22.7 |
um |
1.4 |
3.13 |
ex vivo videomicroscopy |
renal afferent arteriole |
120.0 |
|
|
ex vivo videomicroscopy (MMO:0000319) |
renal afferent arteriole diameter (CMO:0003725) |
renal arteriole morphology trait |
106503 |
3030 |
| SS-Chr 2BN/Mcwi |
renal afferent arteriole diameter |
controlled sodium chloride content diet (1 %) (between 70 and 91 days) then controlled ex vivo artery perfusion pressure (60 mmHg) (for 0.1 hours) |
Miller B, et al., J Clin Invest. 2016 Jul 1;126(7):2533-46. doi: 10.1172/JCI75079. Epub 2016 Jun 6. |
kidney arteriole morphology trait |
not specified |
91.0 days-133.0 days |
6 |
|
|
20.7 |
um |
1.8 |
4.41 |
ex vivo videomicroscopy |
renal afferent arteriole |
120.0 |
|
|
ex vivo videomicroscopy (MMO:0000319) |
renal afferent arteriole diameter (CMO:0003725) |
renal arteriole morphology trait |
106505 |
3030 |
| SS/JrHsdMcwi |
blood T lymphocyte count |
controlled sodium chloride content diet (0.4 %) (for 42 days) |
Rudemiller NP, et al., Hypertension. 2015 May;65(5):1111-7. doi: 10.1161/HYPERTENSIONAHA.114.04736. Epub 2015 Mar 16. |
T cell quantity |
not specified |
63.0 days
| 4 |
|
|
3.3 |
x 10E6 cells/ml |
0.5 |
1.0 |
flow cytometry method |
|
0.0 |
|
|
|
n=4-7 |
|
106512 |
3031 |
| SS-Sh2b3em1Mcwi-/- |
blood B lymphocyte count |
controlled sodium chloride content diet (0.4 %) (for 42 days) |
Rudemiller NP, et al., Hypertension. 2015 May;65(5):1111-7. doi: 10.1161/HYPERTENSIONAHA.114.04736. Epub 2015 Mar 16. |
B cell quantity |
not specified |
63.0 days
| 4 |
|
|
4.0 |
x 10E6 cells/ml |
0.3 |
0.6 |
flow cytometry method |
|
0.0 |
|
|
|
n=4-7 |
|
106515 |
3031 |
| SS-Sh2b3em1Mcwi-/- |
urine albumin excretion rate |
controlled sodium chloride content diet (0.4 %) (for 42 days) |
Rudemiller NP, et al., Hypertension. 2015 May;65(5):1111-7. doi: 10.1161/HYPERTENSIONAHA.114.04736. Epub 2015 Mar 16. |
urine albumin amount |
not specified |
63.0 days
| 6 |
|
|
3.6 |
mg/d |
0.3 |
0.73 |
urine albumin analysis |
|
0.0 |
|
|
|
n=6-8 |
|
106525 |
3031 |
| SS/JrHsdMcwi |
kidney total CD45 positive leukocyte count |
controlled sodium chloride content diet (0.4 %) (for 21 days) |
Rudemiller NP, et al., Hypertension. 2015 May;65(5):1111-7. doi: 10.1161/HYPERTENSIONAHA.114.04736. Epub 2015 Mar 16. |
leukocyte quantity |
not specified |
84.0 days
| 5 |
|
|
2.13 |
x 10E6 cells/ml |
0.36 |
0.8 |
flow cytometry method |
|
0.0 |
|
|
|
n=5-6 |
|
106531 |
3031 |
| SS-Sh2b3em1Mcwi-/- |
kidney total CD45 positive leukocyte count |
controlled sodium chloride content diet (0.4 %) (for 21 days) then controlled sodium chloride content diet (4 %) (for 21 days) |
Rudemiller NP, et al., Hypertension. 2015 May;65(5):1111-7. doi: 10.1161/HYPERTENSIONAHA.114.04736. Epub 2015 Mar 16. |
leukocyte quantity |
not specified |
84.0 days
| 5 |
|
|
1.84 |
x 10E6 cells/ml |
0.3 |
0.67 |
flow cytometry method |
|
0.0 |
|
|
|
n=5-6 |
|
106534 |
3031 |
| SBH/Ygl |
body weight |
controlled sodium chloride content diet (8 %) (for 42 days) |
Landau D, et al., J Endocrinol. 2008 Apr;197(1):75-83. doi: 10.1677/JOE-08-0040. |
body mass |
male |
98.0 days
| 7 |
|
|
270.0 |
g |
7.0 |
18.52 |
body weighing method |
|
0.0 |
|
|
|
|
|
106701 |
3038 |
| SBH/Ygl |
heart left ventricle fractional shortening |
controlled sodium chloride content diet (8 %) (for 42 days) then streptozotocin (60 mg/kg) then insulin (10 ul) (for 42 days) |
Landau D, et al., J Endocrinol. 2008 Apr;197(1):75-83. doi: 10.1677/JOE-08-0040. |
heart left ventricle end-diastolic diameter |
male |
98.0 days
| 7 |
|
|
65.0 |
% |
1.0 |
2.65 |
transthoracic echocardiography |
|
0.0 |
|
|
|
|
|
106715 |
3038 |
| SBH/Ygl |
heart left ventricle end-diastolic diameter to body weight ratio |
controlled sodium chloride content diet (0.65 %) (for 98 days) |
Landau D, et al., J Endocrinol. 2008 Apr;197(1):75-83. doi: 10.1677/JOE-08-0040. |
heart left ventricle end-diastolic diameter |
male |
98.0 days
| 7 |
|
|
1.9 |
mm/kg |
0.01 |
0.03 |
transthoracic echocardiography |
|
0.0 |
|
|
|
|
|
106716 |
3038 |
| SBH/Ygl |
heart left ventricle end-systolic diameter to body weight ratio |
controlled sodium chloride content diet (0.65 %) (for 98 days) |
Landau D, et al., J Endocrinol. 2008 Apr;197(1):75-83. doi: 10.1677/JOE-08-0040. |
heart left ventricle end-systolic diameter |
male |
98.0 days
| 7 |
|
|
0.65 |
mm/kg |
0.02 |
0.05 |
transthoracic echocardiography |
|
0.0 |
|
|
|
|
|
106720 |
3038 |
| SBH/Ygl |
heart left ventricle end-systolic diameter to body weight ratio |
controlled sodium chloride content diet (8 %) (for 42 days) |
Landau D, et al., J Endocrinol. 2008 Apr;197(1):75-83. doi: 10.1677/JOE-08-0040. |
heart left ventricle end-systolic diameter |
male |
98.0 days
| 7 |
|
|
0.8 |
mm/kg |
0.07 |
0.19 |
transthoracic echocardiography |
|
0.0 |
|
|
|
|
|
106721 |
3038 |
| SS/HsdMcwiCrl |
heart rate |
controlled sodium chloride content diet (8 %) (between 28 and 42 days) |
Gabor A and Leenen FH, Brain Res. 2012 Apr 4;1447:28-37. doi: 10.1016/j.brainres.2012.01.060. Epub 2012 Feb 1. |
heart pumping trait |
male |
77.0 days-98.0 days |
5 |
|
|
444.0 |
beats/min |
16.0 |
35.78 |
vascular fluid filled catheter |
femoral artery |
600.0 |
|
|
|
|
|
106777 |
2685 |
| SS/HsdMcwiCrl |
heart rate |
controlled sodium chloride content diet (8 %) (between 28 and 42 days) then 2% dimethyl sulfoxide in artificial cerebrospinal fluid (300 nl/min) (for 0.2 hours) then kynurenate (0.14 ug/min) (for 0.2 hours) |
Gabor A and Leenen FH, Brain Res. 2012 Apr 4;1447:28-37. doi: 10.1016/j.brainres.2012.01.060. Epub 2012 Feb 1. |
heart pumping trait |
male |
77.0 days-98.0 days |
4 |
|
|
425.0 |
beats/min |
11.0 |
22.0 |
vascular fluid filled catheter |
femoral artery |
600.0 |
|
|
|
|
|
106779 |
2685 |
| SS/HsdMcwiCrl |
heart rate |
controlled sodium chloride content diet (0.1 %) (between 28 and 42 days) then candesartan (0.5 ug/min) (for 0.2 hours) then kynurenate (0.14 ug/min) (for 0.2 hours) |
Gabor A and Leenen FH, Brain Res. 2012 Apr 4;1447:28-37. doi: 10.1016/j.brainres.2012.01.060. Epub 2012 Feb 1. |
heart pumping trait |
male |
77.0 days-98.0 days |
4 |
|
|
459.0 |
beats/min |
9.0 |
18.0 |
vascular fluid filled catheter |
femoral artery |
600.0 |
|
|
|
|
|
106782 |
2685 |
| SS-Chr 13BN/McwiCrl |
mean arterial blood pressure |
controlled sodium chloride content diet (8 %) (between 28 and 42 days) |
Gabor A and Leenen FH, Brain Res. 2012 Apr 4;1447:28-37. doi: 10.1016/j.brainres.2012.01.060. Epub 2012 Feb 1. |
arterial blood pressure trait |
male |
77.0 days-98.0 days |
5 |
MAP=.33(SP-DP) + DP |
|
112.0 |
mmHg |
3.0 |
6.71 |
vascular fluid filled catheter |
femoral artery |
600.0 |
|
|
|
|
|
106760 |
2685 |
| SS-Chr 13BN/McwiCrl |
mean arterial blood pressure |
controlled sodium chloride content diet (0.1 %) (between 28 and 42 days) |
Gabor A and Leenen FH, Brain Res. 2012 Apr 4;1447:28-37. doi: 10.1016/j.brainres.2012.01.060. Epub 2012 Feb 1. |
arterial blood pressure trait |
male |
77.0 days-98.0 days |
4 |
MAP=.33(SP-DP) + DP |
|
106.0 |
mmHg |
4.0 |
8.0 |
vascular fluid filled catheter |
femoral artery |
600.0 |
|
|
|
|
|
106759 |
2685 |
| SS-Chr 13BN/McwiCrl |
mean arterial blood pressure |
controlled sodium chloride content diet (8 %) (between 28 and 42 days) then candesartan (0.5 ug/min) (for 0.2 hours) then kynurenate (0.14 ug/min) (for 0.2 hours) |
Gabor A and Leenen FH, Brain Res. 2012 Apr 4;1447:28-37. doi: 10.1016/j.brainres.2012.01.060. Epub 2012 Feb 1. |
arterial blood pressure trait |
male |
77.0 days-98.0 days |
4 |
MAP=.33(SP-DP) + DP |
|
110.0 |
mmHg |
2.0 |
4.0 |
vascular fluid filled catheter |
femoral artery |
600.0 |
|
|
|
|
|
106761 |
2685 |
| SS/HsdMcwiCrl |
mean arterial blood pressure |
controlled sodium chloride content diet (0.1 %) (between 28 and 42 days) then candesartan (0.5 ug/min) (for 0.2 hours) then kynurenate (0.14 ug/min) (for 0.2 hours) |
Gabor A and Leenen FH, Brain Res. 2012 Apr 4;1447:28-37. doi: 10.1016/j.brainres.2012.01.060. Epub 2012 Feb 1. |
arterial blood pressure trait |
male |
77.0 days-98.0 days |
4 |
MAP=.33(SP-DP) + DP |
|
111.0 |
mmHg |
4.0 |
8.0 |
vascular fluid filled catheter |
femoral artery |
600.0 |
|
|
|
|
|
106765 |
2685 |
| SS/HsdMcwiCrl |
mean arterial blood pressure |
controlled sodium chloride content diet (8 %) (between 28 and 42 days) then kynurenate (0.14 ug/min) (for 0.2 hours) then candesartan (0.5 ug/min) (for 0.2 hours) |
Gabor A and Leenen FH, Brain Res. 2012 Apr 4;1447:28-37. doi: 10.1016/j.brainres.2012.01.060. Epub 2012 Feb 1. |
arterial blood pressure trait |
male |
77.0 days-98.0 days |
5 |
MAP=.33(SP-DP) + DP |
|
128.0 |
mmHg |
6.0 |
13.42 |
vascular fluid filled catheter |
femoral artery |
600.0 |
|
|
|
|
|
106769 |
2685 |
| SS/HsdMcwiCrl |
heart rate |
controlled sodium chloride content diet (8 %) (between 28 and 42 days) |
Gabor A and Leenen FH, Brain Res. 2012 Apr 4;1447:28-37. doi: 10.1016/j.brainres.2012.01.060. Epub 2012 Feb 1. |
heart pumping trait |
male |
77.0 days-98.0 days |
4 |
|
|
435.0 |
beats/min |
12.0 |
24.0 |
vascular fluid filled catheter |
femoral artery |
600.0 |
|
|
|
|
|
106771 |
2685 |
| SBH/Ygl |
blood glucose level |
controlled sodium chloride content diet (8 %) (for 42 days) then streptozotocin (60 mg/kg) then insulin (10 ul) (for 42 days) |
Landau D, et al., J Endocrinol. 2008 Apr;197(1):75-83. doi: 10.1677/JOE-08-0040. |
blood glucose amount |
male |
98.0 days
| 7 |
|
|
361.8 |
mg/dl |
32.4 |
85.72 |
blood glucose test strip read by electrochemical glucometer |
|
0.0 |
|
|
|
|
|
106695 |
3038 |
| LH/MavRrrcAek |
body weight to body length (nose to rump) ratio |
standard rat chow (for 98 days) then controlled sodium chloride content diet (4 %) (for 14 days) |
Wang J, et al., Circ Cardiovasc Genet. 2015 Apr;8(2):316-26. doi: 10.1161/CIRCGENETICS.114.000520. Epub 2015 Jan 8. |
body mass |
male |
112.0 days
| |
|
|
17.0 |
g/cm |
0.21 |
|
body weighing method |
|
0.0 |
|
|
|
|
|
107400 |
3014 |
| LN/MavRrrcAek |
body weight to body length (nose to rump) ratio |
standard rat chow (for 98 days) then controlled sodium chloride content diet (4 %) (for 14 days) |
Wang J, et al., Circ Cardiovasc Genet. 2015 Apr;8(2):316-26. doi: 10.1161/CIRCGENETICS.114.000520. Epub 2015 Jan 8. |
body mass |
male |
112.0 days
| |
|
|
13.2 |
g/cm |
0.22 |
|
body weighing method |
|
0.0 |
|
|
|
|
|
107401 |
3014 |
| MNS/Gib |
systolic blood pressure |
controlled sodium chloride content diet (2.5 g/kg) |
Ferrandi M, etal., Am J Physiol. 1999 Oct;277(4):H1338-49. doi: 10.1152/ajpheart.1999.277.4.H1338. |
arterial blood pressure trait |
male |
91.0 days
| |
|
|
132.0 |
mmHg |
1.8 |
|
tail cuff plethysmography |
|
0.0 |
|
|
|
|
|
110653 |
3135 |
| SS/Jr |
ouabain-sensitive red blood cell Na+ export rate |
controlled sodium chloride content diet (0.3 %) (for 35 days) |
Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. |
erythrocyte ion transport trait |
male |
63.0 days
| 15 |
|
|
3908.0 |
umol/l/h |
104.0 |
402.79 |
Na+/K+ ATPase activity assay |
|
0.0 |
|
|
|
|
|
111035 |
2802 |
| SS/Jr |
ouabain- and bumetanide-resistant red blood cell Na+ import rate |
controlled sodium chloride content diet (0.3 %) (for 35 days) |
Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. |
erythrocyte ion transport trait |
male |
63.0 days
| 15 |
|
|
3803.0 |
umol/l/h |
134.0 |
518.98 |
Na+ passive permeability assay |
|
0.0 |
|
|
|
|
|
111043 |
2802 |
| SS/Jr |
bumetanide-sensitive red blood cell Na+ export rate |
controlled sodium chloride content diet (0.3 %) (for 35 days) |
Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. |
erythrocyte ion transport trait |
male |
63.0 days
| 15 |
|
|
84.0 |
umol/l/h |
65.0 |
251.74 |
Na-K-Cl cotransport activity assay |
|
0.0 |
|
|
|
|
|
111039 |
2802 |
| SS/Jr |
ouabain-sensitive red blood cell K+ import rate |
controlled sodium chloride content diet (8 %) (for 35 days) |
Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. |
erythrocyte ion transport trait |
male |
63.0 days
| 10 |
|
|
6084.0 |
umol/l/h |
562.0 |
1777.2 |
Na+/K+ ATPase activity assay |
|
0.0 |
|
|
|
|
|
111048 |
2802 |
| SS/Jr |
bumetanide-sensitive red blood cell K+ import rate |
controlled sodium chloride content diet (8 %) (for 35 days) |
Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. |
erythrocyte ion transport trait |
male |
63.0 days
| 10 |
|
|
1145.0 |
umol/l/h |
166.0 |
524.94 |
Na-K-Cl cotransport activity assay |
|
0.0 |
|
|
|
|
|
111052 |
2802 |
| SS/Jr |
ouabain- and bumetanide-resistant red blood cell K+ import rate |
controlled sodium chloride content diet (0.3 %) (for 35 days) |
Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. |
erythrocyte ion transport trait |
male |
63.0 days
| 15 |
|
|
424.0 |
umol/l/h |
14.0 |
54.22 |
Na+ passive permeability assay |
|
0.0 |
|
|
|
|
|
111055 |
2802 |
| MWF/Fub |
systolic blood pressure |
controlled sodium chloride content diet (8 %) (for 56 days) |
Kreutz R, etal., J Hypertens. 2000 Jun;18(6):777-82. doi: 10.1097/00004872-200018060-00017. |
arterial blood pressure trait |
male |
100.0 days-103.0 days |
8 |
|
|
133.0 |
mmHg |
3.0 |
8.49 |
tail cuff plethysmography |
tail |
0.0 |
|
|
|
|
|
109023 |
3134 |
| SR/Hsd |
mean arterial blood pressure |
controlled sodium chloride content diet (8 %) (for 42 days) |
Wu F, et al., Int J Hypertens. 2016;2016:9146870. doi: 10.1155/2016/9146870. Epub 2016 Dec 19. |
arterial blood pressure trait |
male |
91.0 days
| 8 |
|
|
114.0 |
mmHg |
2.12 |
6.0 |
tail cuff plethysmography |
|
0.0 |
|
|
|
|
|
102269 |
2683 |
| SR/Hsd |
body weight |
controlled sodium chloride content diet (8 %) (for 42 days) |
Wu F, et al., Int J Hypertens. 2016;2016:9146870. doi: 10.1155/2016/9146870. Epub 2016 Dec 19. |
body mass |
male |
91.0 days
| 8 |
|
|
308.0 |
g |
10.61 |
30.0 |
body weighing method |
|
0.0 |
|
|
|
|
|
102273 |
2683 |
| SS/Jr |
heart weight |
controlled sodium chloride content diet (0.3 %) (for 21 days) then controlled sodium chloride content diet (8 %) (for 42 days) |
Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. |
heart mass |
not specified |
84.0 days
| 5 |
|
|
1.36 |
g |
0.02 |
0.06 |
post excision weight measurement |
|
0.0 |
|
|
|
|
|
103143 |
2787 |
| SS/Jr |
body weight |
controlled sodium chloride content diet (0.3 %) (for 21 days) then controlled sodium chloride content diet (8 %) (for 42 days) |
Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. |
body mass |
not specified |
84.0 days
| 5 |
|
|
332.0 |
g |
22.36 |
50.0 |
body weighing method |
|
0.0 |
|
|
|
|
|
103141 |
2787 |
| SR/Jr |
left ventricular systolic blood pressure |
controlled sodium chloride content diet (0.3 %) (for 21 days) then controlled sodium chloride content diet (8 %) (for 42 days) then pentobarbital, sodium (20 mg/kg) |
Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. |
heart left ventricular blood pressure trait |
not specified |
84.0 days
| 5 |
|
|
119.0 |
mmHg |
4.02 |
9.0 |
vascular transducer tipped catheter |
|
0.0 |
|
|
|
|
|
103150 |
2787 |
| SR/Jr |
maximum rate of positive change in left ventricular blood pressure |
controlled sodium chloride content diet (0.3 %) (for 21 days) then controlled sodium chloride content diet (8 %) (for 42 days) then pentobarbital, sodium (20 mg/kg) |
Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. |
heart left ventricular blood pressure trait |
not specified |
84.0 days
| 5 |
LVdP/dtmax |
|
8600.0 |
mmHg/s |
715.54 |
1600.0 |
vascular transducer tipped catheter |
|
0.0 |
|
|
|
E3 X mmHg/s |
|
103154 |
2787 |
| SR/Jr |
heart rate |
controlled sodium chloride content diet (0.3 %) (for 21 days) then controlled sodium chloride content diet (8 %) (for 42 days) then ambient air (between 0 and 0.1 hours) |
Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. |
heart pumping trait |
not specified |
86.0 days
| 5 |
sampling once per minute |
|
341.0 |
beats/min |
1.79 |
4.0 |
intra-aortic thoracic radiotelemetry |
|
0.0 |
|
|
|
|
|
103156 |
2787 |
| SS/Jr |
heart rate |
controlled sodium chloride content diet (0.3 %) (for 21 days) then controlled sodium chloride content diet (8 %) (for 42 days) then 10% CO2, 20% O2, 70% N2 (between 0 and 0.4 hours) |
Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. |
heart pumping trait |
not specified |
86.0 days
| 5 |
sampling once per minute |
|
336.0 |
beats/min |
5.37 |
12.0 |
intra-aortic thoracic radiotelemetry |
|
0.0 |
|
|
|
|
|
103159 |
2787 |
| SR/Jr |
heart rate |
controlled sodium chloride content diet (0.3 %) (for 21 days) then controlled sodium chloride content diet (8 %) (for 42 days) then atropine (1 mg/kg) (between 0.5 and 0.6 hours) then 10% CO2, 20% O2, 70% N2 (between 0 and 0.1 hours) |
Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. |
heart pumping trait |
not specified |
86.0 days
| 5 |
sampling once per minute |
|
455.0 |
beats/min |
4.47 |
10.0 |
intra-aortic thoracic radiotelemetry |
|
0.0 |
5 |
min |
|
|
|
103191 |
2787 |
| SS/Jr |
heart rate |
controlled sodium chloride content diet (0.3 %) (for 21 days) then controlled sodium chloride content diet (8 %) (for 42 days) then atropine (1 mg/kg) (between 0.5 and 0.6 hours) then 10% CO2, 20% O2, 70% N2 (between 0 and 0.1 hours) |
Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. |
heart pumping trait |
not specified |
86.0 days
| 4 |
sampling once per minute |
|
438.0 |
beats/min |
7.0 |
14.0 |
intra-aortic thoracic radiotelemetry |
|
0.0 |
5 |
min |
|
|
|
103190 |
2787 |
| SR/Jr |
heart rate |
controlled sodium chloride content diet (0.3 %) (for 21 days) then controlled sodium chloride content diet (8 %) (for 42 days) then atropine (1 mg/kg) (between 0.5 and 0.9 hours) then 10% CO2, 20% O2, 70% N2 (between 0 and 0.4 hours) |
Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. |
heart pumping trait |
not specified |
86.0 days
| 5 |
sampling once per minute |
|
436.0 |
beats/min |
8.5 |
19.0 |
intra-aortic thoracic radiotelemetry |
|
0.0 |
25 |
min |
|
|
|
103193 |
2787 |
| SS/Jr |
mean arterial blood pressure |
controlled sodium chloride content diet (0.3 %) (for 42 days) then controlled sodium chloride content diet (8 %) (for 42 days) then atropine (1 mg/kg) then 10% CO2, 20% O2, 70% N2 (between 0 and 0.4 hours) |
Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. |
arterial blood pressure trait |
not specified |
86.0 days
| 4 |
sampling once per minute |
|
135.0 |
mmHg |
1.5 |
3.0 |
intra-aortic thoracic radiotelemetry |
|
0.0 |
|
|
|
|
|
103202 |
2787 |
| SS/Jr |
mean arterial blood pressure |
controlled sodium chloride content diet (0.3 %) (for 42 days) then controlled sodium chloride content diet (8 %) (for 42 days) then atropine (1 mg/kg) then 10% CO2, 20% O2, 70% N2 (between 0 and 0.4 hours) then ambient air (between 0 and 0.4 hours) |
Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. |
arterial blood pressure trait |
not specified |
86.0 days
| 4 |
sampling once per minute |
|
131.0 |
mmHg |
2.0 |
4.0 |
intra-aortic thoracic radiotelemetry |
|
0.0 |
|
|
|
|
|
103206 |
2787 |
| SR/JrHsd |
body weight |
controlled sodium chloride content diet (4 %) (for 14 days) then bilateral ovariectomy then peanut oil (0.2 ml) (for 14 days) |
Zheng W, et al., Am J Physiol Heart Circ Physiol. 2008 Apr;294(4):H1508-13. doi: 10.1152/ajpheart.01322.2007. Epub 2008 Feb 1. |
body mass |
female |
days
| |
|
|
269.0 |
g |
7.3 |
|
body weighing method |
|
0.0 |
|
|
|
|
|
102186 |
2681 |
| SS/JrHsd |
body weight |
controlled sodium chloride content diet (0.4 %) (for 14 days) then bilateral ovariectomy then 17 beta-estradiol (10 ug/d) (for 14 days) |
Zheng W, et al., Am J Physiol Heart Circ Physiol. 2008 Apr;294(4):H1508-13. doi: 10.1152/ajpheart.01322.2007. Epub 2008 Feb 1. |
body mass |
female |
days
| |
|
|
211.0 |
g |
4.6 |
|
body weighing method |
|
0.0 |
|
|
|
|
|
102193 |
2681 |
| SR/JrHsd |
single kidney wet weight |
controlled sodium chloride content diet (4 %) (for 14 days) then bilateral ovariectomy then 17 beta-estradiol (10 ug/d) (for 14 days) |
Zheng W, et al., Am J Physiol Heart Circ Physiol. 2008 Apr;294(4):H1508-13. doi: 10.1152/ajpheart.01322.2007. Epub 2008 Feb 1. |
kidney mass |
female |
days
| |
|
|
1.11 |
g |
0.02 |
|
post excision weight measurement |
|
0.0 |
|
|
|
|
|
102200 |
2681 |
| SS/JrHsd |
single kidney wet weight |
controlled sodium chloride content diet (0.4 %) (for 14 days) then bilateral ovariectomy then peanut oil (0.2 ml) (for 14 days) |
Zheng W, et al., Am J Physiol Heart Circ Physiol. 2008 Apr;294(4):H1508-13. doi: 10.1152/ajpheart.01322.2007. Epub 2008 Feb 1. |
kidney mass |
female |
days
| |
|
|
0.91 |
g |
0.01 |
|
post excision weight measurement |
|
0.0 |
|
|
|
|
|
102203 |
2681 |
| SS/JrHsd |
single kidney wet weight |
controlled sodium chloride content diet (0.4 %) (for 14 days) then bilateral ovariectomy then 17 beta-estradiol (10 ug/d) (for 14 days) |
Zheng W, et al., Am J Physiol Heart Circ Physiol. 2008 Apr;294(4):H1508-13. doi: 10.1152/ajpheart.01322.2007. Epub 2008 Feb 1. |
kidney mass |
female |
days
| |
|
|
1.1 |
g |
0.07 |
|
post excision weight measurement |
|
0.0 |
|
|
|
|
|
102205 |
2681 |
| SR/NEisSlc |
kidney medullary adrenomedullin level |
controlled sodium chloride content diet (8 %) (for 21 days) |
Yoshihara F, et al., Regul Pept. 2005 May 15;128(1):7-13. |
kidney adrenomedullin amount |
male |
77.0 days
| 7 |
|
|
0.34 |
fmol/mg |
0.01 |
0.02 |
radioimmunoassay |
|
0.0 |
|
|
|
|
|
102451 |
2689 |
| SR/NEisSlc |
heart rate |
controlled sodium chloride content diet (8 %) (for 21 days) then 0.9% sodium chloride solution (for 21 days) |
Yoshihara F, et al., Regul Pept. 2005 May 15;128(1):7-13. |
heart pumping trait |
male |
77.0 days
| 19 |
|
|
347.0 |
beats/min |
7.34 |
32.0 |
tail cuff plethysmography |
|
0.0 |
|
|
|
|
|
102456 |
2689 |
| SS/NEisSlc |
body weight |
controlled sodium chloride content diet (8 %) (for 21 days) then adrenomedulin (400 ng/hr) (for 21 days) |
Yoshihara F, et al., Regul Pept. 2005 May 15;128(1):7-13. |
body mass |
male |
77.0 days
| 14 |
|
|
350.0 |
g |
3.74 |
14.0 |
body weighing method |
|
0.0 |
|
|
|
|
|
102455 |
2689 |
| SS/NEisSlc |
heart left ventricle plus septum weight to body weight ratio |
controlled sodium chloride content diet (8 %) (for 21 days) then adrenomedulin (400 ng/hr) (for 21 days) |
Yoshihara F, et al., Regul Pept. 2005 May 15;128(1):7-13. |
heart left ventricle mass |
male |
77.0 days
| 14 |
|
|
2.32 |
mg/g |
0.04 |
0.14 |
post excision weight measurement |
|
0.0 |
|
|
|
heart left ventricle plus septum weight to body weight ratio (CMO:0003869) |
|
102461 |
2689 |
| SS/NEisSlc |
heart left ventricle plus septum weight to body weight ratio |
controlled sodium chloride content diet (8 %) (for 21 days) then 0.9% sodium chloride solution (for 21 days) |
Yoshihara F, et al., Regul Pept. 2005 May 15;128(1):7-13. |
heart left ventricle mass |
male |
77.0 days
| 14 |
|
|
2.54 |
mg/g |
0.03 |
0.13 |
post excision weight measurement |
|
0.0 |
|
|
|
heart left ventricle plus septum weight to body weight ratio (CMO:0003869) |
|
102460 |
2689 |
| SR/NEisSlc |
single kidney wet weight to body weight ratio |
controlled sodium chloride content diet (8 %) (for 21 days) then 0.9% sodium chloride solution (for 21 days) |
Yoshihara F, et al., Regul Pept. 2005 May 15;128(1):7-13. |
kidney mass |
male |
77.0 days
| 19 |
|
|
3.85 |
g/kg |
0.06 |
0.28 |
post excision weight measurement |
|
0.0 |
|
|
|
|
|
102462 |
2689 |
| SS/NEisSlc |
single kidney wet weight to body weight ratio |
controlled sodium chloride content diet (8 %) (for 21 days) then 0.9% sodium chloride solution (for 21 days) |
Yoshihara F, et al., Regul Pept. 2005 May 15;128(1):7-13. |
kidney mass |
male |
77.0 days
| 14 |
|
|
4.63 |
g/kg |
0.07 |
0.26 |
post excision weight measurement |
|
0.0 |
|
|
|
|
|
102463 |
2689 |
| SR/NEisSlc |
systolic blood pressure |
controlled sodium chloride content diet (8 %) (for 21 days) then 0.9% sodium chloride solution (for 21 days) |
Yoshihara F, et al., Regul Pept. 2005 May 15;128(1):7-13. |
arterial blood pressure trait |
male |
77.0 days
| 19 |
mean of 3 samples of undefined duration |
serial mean |
128.0 |
mmHg |
1.38 |
6.0 |
tail cuff plethysmography |
|
0.0 |
|
|
|
|
|
102465 |
2689 |
| SS/NEisSlc |
single kidney wet weight to body weight ratio |
controlled sodium chloride content diet (8 %) (for 21 days) then adrenomedulin (400 ng/hr) (for 21 days) |
Yoshihara F, et al., Regul Pept. 2005 May 15;128(1):7-13. |
kidney mass |
male |
77.0 days
| 14 |
|
|
4.52 |
g/kg |
0.07 |
0.27 |
post excision weight measurement |
|
0.0 |
|
|
|
|
|
102464 |
2689 |
| SS/NEisSlc |
urine sodium excretion rate |
controlled sodium chloride content diet (8 %) (for 21 days) then adrenomedulin (400 ng/hr) (for 21 days) |
Yoshihara F, et al., Regul Pept. 2005 May 15;128(1):7-13. |
urine sodium amount |
male |
77.0 days
| 14 |
|
|
1.7 |
mEq/d |
0.13 |
0.5 |
automated urine sodium analysis |
|
0.0 |
|
|
|
|
|
102470 |
2689 |
| SR/NEisSlc |
body weight |
controlled sodium chloride content diet (0.3 %) (for 42 days) then controlled sodium chloride content diet (8 %) (for 84 days) |
Horinaka S, et al., Int J Cardiol. 2003 Sep;91(1):25-35. |
body mass |
male |
126.0 days
| 10 |
|
|
483.0 |
g |
5.69 |
18.0 |
body weighing method |
|
0.0 |
|
|
|
|
|
102481 |
2690 |
| SR/NEisSlc |
heart left ventricle weight |
controlled sodium chloride content diet (0.3 %) (for 42 days) then controlled sodium chloride content diet (8 %) (for 35 days) |
Horinaka S, et al., Int J Cardiol. 2003 Sep;91(1):25-35. |
heart left ventricle mass |
male |
77.0 days
| 10 |
|
|
0.83 |
g |
0.0 |
0.0 |
post excision weight measurement |
|
0.0 |
|
|
|
|
|
102484 |
2690 |
| SR/NEisSlc |
heart left ventricle weight to body weight ratio |
controlled sodium chloride content diet (0.3 %) (for 42 days) then controlled sodium chloride content diet (8 %) (for 84 days) |
Horinaka S, et al., Int J Cardiol. 2003 Sep;91(1):25-35. |
heart left ventricle mass |
male |
126.0 days
| 10 |
|
|
1.95 |
mg/g |
0.03 |
0.09 |
post excision weight measurement |
|
0.0 |
|
|
|
|
|
102489 |
2690 |
| SR/NEisSlc |
heart left ventricle weight to body weight ratio |
controlled sodium chloride content diet (0.3 %) (for 42 days) then controlled sodium chloride content diet (8 %) (for 35 days) |
Horinaka S, et al., Int J Cardiol. 2003 Sep;91(1):25-35. |
heart left ventricle mass |
male |
77.0 days
| 10 |
|
|
2.33 |
mg/g |
0.03 |
0.09 |
post excision weight measurement |
|
0.0 |
|
|
|
|
|
102488 |
2690 |
| SS/NEisSlc |
heart rate |
controlled sodium chloride content diet (0.3 %) (for 42 days) then controlled sodium chloride content diet (8 %) (for 84 days) |
Horinaka S, et al., Int J Cardiol. 2003 Sep;91(1):25-35. |
heart pumping trait |
male |
126.0 days
| 10 |
|
|
415.0 |
beats/min |
8.85 |
28.0 |
tail cuff plethysmography |
|
0.0 |
|
|
|
|
|
102497 |
2690 |
| SS/NEisSlc |
left ventricular systolic blood pressure |
controlled sodium chloride content diet (0.3 %) (for 42 days) then controlled sodium chloride content diet (8 %) (for 84 days) then pentobarbital (20 mg/kg) |
Horinaka S, et al., Int J Cardiol. 2003 Sep;91(1):25-35. |
heart left ventricular blood pressure trait |
male |
126.0 days
| 10 |
|
|
107.0 |
mmHg |
5.69 |
18.0 |
volume pressure recording |
|
0.0 |
|
|
|
|
|
102501 |
2690 |
| SR/NEisSlc |
end-systolic volume |
controlled sodium chloride content diet (0.3 %) (for 42 days) then controlled sodium chloride content diet (8 %) (for 84 days) then pentobarbital (20 mg/kg) |
Horinaka S, et al., Int J Cardiol. 2003 Sep;91(1):25-35. |
cardiac output trait |
male |
126.0 days
| 10 |
|
|
0.09 |
ml |
0.02 |
0.06 |
volume pressure recording |
|
0.0 |
|
|
|
|
|
102513 |
2690 |
| SS/NEisSlc |
heart left ventricle diastolic volume-axis intercept |
controlled sodium chloride content diet (0.3 %) (for 42 days) then controlled sodium chloride content diet (8 %) (for 84 days) then pentobarbital (20 mg/kg) |
Horinaka S, et al., Int J Cardiol. 2003 Sep;91(1):25-35. |
cardiac output trait |
male |
126.0 days
| 10 |
|
|
0.08 |
ml |
0.02 |
0.06 |
volume pressure recording |
|
0.0 |
|
|
|
|
|
102535 |
2690 |
| SR/NEisSlc |
time constant of left ventricular pressure decay |
controlled sodium chloride content diet (0.3 %) (for 42 days) then controlled sodium chloride content diet (8 %) (for 35 days) then pentobarbital (20 mg/kg) |
Horinaka S, et al., Int J Cardiol. 2003 Sep;91(1):25-35. |
heart left ventricular blood pressure trait |
male |
77.0 days
| 10 |
|
|
107.0 |
ms |
0.79 |
2.5 |
volume pressure recording |
|
0.0 |
|
|
|
|
|
102536 |
2690 |
| SS/NEisSlc |
time constant of left ventricular pressure decay |
controlled sodium chloride content diet (0.3 %) (for 42 days) then controlled sodium chloride content diet (8 %) (for 35 days) then pentobarbital (20 mg/kg) |
Horinaka S, et al., Int J Cardiol. 2003 Sep;91(1):25-35. |
heart left ventricular blood pressure trait |
male |
77.0 days
| 10 |
|
|
15.8 |
ms |
1.68 |
5.3 |
volume pressure recording |
|
0.0 |
|
|
|
|
|
102538 |
2690 |
| SS/NEisSlc |
time constant of left ventricular pressure decay |
controlled sodium chloride content diet (0.3 %) (for 42 days) then controlled sodium chloride content diet (8 %) (for 84 days) then pentobarbital (20 mg/kg) |
Horinaka S, et al., Int J Cardiol. 2003 Sep;91(1):25-35. |
heart left ventricular blood pressure trait |
male |
126.0 days
| 10 |
|
|
19.4 |
ms |
0.66 |
2.1 |
volume pressure recording |
|
0.0 |
|
|
|
|
|
102539 |
2690 |
| SS.BN-(D13Rat130-D13Rat32)/Mcwi |
urine albumin excretion rate |
controlled sodium chloride content diet (0.4 %) (between 46 and 50.8 days) then controlled sodium chloride content diet (8 %) (for 13.4 days) |
Cowley AW, et al., Physiol Genomics. 2014 Jun 1;46(11):398-410. doi: 10.1152/physiolgenomics.00179.2013. Epub 2014 Apr 8. |
urine albumin amount |
male |
60.0 days-67.0 days |
12 |
|
|
113.0 |
mg/d |
10.0 |
34.64 |
urine microalbumin analysis |
|
0.0 |
|
|
|
strain 26-K |
|
98636 |
2098 |
| SS.BN-(D13Hmgc64-RN34_13048990782)/Mcwi |
mean arterial blood pressure |
controlled sodium chloride content diet (0.4 %) (for 70 days) then controlled sodium chloride content diet (8 %) (for 21 days) |
Hoffman MJ, et al., Hypertension. 2013 Sep;62(3):557-63. doi: 10.1161/HYPERTENSIONAHA.113.01708. Epub 2013 Jul 1. |
arterial blood pressure trait |
male |
91.0 days
| 11 |
|
serial mean |
173.0 |
mmHg |
7.0 |
23.22 |
intra-aortic abdominal radiotelemetry via femoral cannulation |
|
10800.0 |
|
|
|
|
|
98701 |
2141 |
| LN/MavRrrcAek |
heart rate |
standard rat chow (for 98 days) then controlled sodium chloride content diet (4 %) (for 21 days) |
Wang J, et al., Circ Cardiovasc Genet. 2015 Apr;8(2):316-26. doi: 10.1161/CIRCGENETICS.114.000520. Epub 2015 Jan 8. |
heart pumping trait |
male |
119.0 days
| 14 |
|
|
346.5 |
beats/min |
2.7 |
10.1 |
intra-aortic abdominal radiotelemetry via femoral cannulation |
|
0.0 |
|
|
|
|
|
102616 |
3014 |
| LN/MavRrrcAek |
body weight area under curve (AUC) |
standard rat chow (for 98 days) then controlled sodium chloride content diet (4 %) (for 21 days) |
Wang J, et al., Circ Cardiovasc Genet. 2015 Apr;8(2):316-26. doi: 10.1161/CIRCGENETICS.114.000520. Epub 2015 Jan 8. |
body mass |
male |
21.0 days-126.0 days |
|
body weight X week = growth AUC |
|
2.8740096E7 |
g x min |
358848.0 |
|
body weighing method |
|
0.0 |
|
|
|
growth auc |
|
102618 |
3014 |
| LN/MavRrrcAek |
combined renal and gonadal fat pad weight |
standard rat chow (for 98 days) then controlled sodium chloride content diet (4 %) (for 21 days) |
Wang J, et al., Circ Cardiovasc Genet. 2015 Apr;8(2):316-26. doi: 10.1161/CIRCGENETICS.114.000520. Epub 2015 Jan 8. |
fat pad morphology trait |
male |
126.0 days
| 14 |
|
|
0.72 |
g |
0.03 |
0.11 |
post excision weight measurement |
|
0.0 |
|
|
|
combined renal and gonadal fat pad weight (CMO:0003886) |
|
102620 |
3014 |
| LH/MavRrrcAek |
plasma triglyceride level |
standard rat chow (for 98 days) then controlled sodium chloride content diet (4 %) (for 14 days) |
Wang J, et al., Circ Cardiovasc Genet. 2015 Apr;8(2):316-26. doi: 10.1161/CIRCGENETICS.114.000520. Epub 2015 Jan 8. |
blood triglyceride amount |
male |
112.0 days
| 9 |
|
|
0.43 |
mmol/l |
0.05 |
0.15 |
plasma triglyceride analysis |
|
0.0 |
|
|
|
|
|
102627 |
3014 |
| LN/MavRrrcAek |
plasma triglyceride level |
standard rat chow (for 98 days) then controlled sodium chloride content diet (4 %) (for 28 days) |
Wang J, et al., Circ Cardiovasc Genet. 2015 Apr;8(2):316-26. doi: 10.1161/CIRCGENETICS.114.000520. Epub 2015 Jan 8. |
blood triglyceride amount |
male |
126.0 days
| 14 |
|
|
0.39 |
mmol/l |
0.05 |
0.19 |
plasma triglyceride analysis |
|
0.0 |
|
|
|
|
|
102630 |
3014 |
| LH/MavRrrcAek |
plasma total cholesterol level |
standard rat chow (for 98 days) then controlled sodium chloride content diet (4 %) (for 28 days) |
Wang J, et al., Circ Cardiovasc Genet. 2015 Apr;8(2):316-26. doi: 10.1161/CIRCGENETICS.114.000520. Epub 2015 Jan 8. |
blood cholesterol amount |
male |
126.0 days
| 9 |
|
|
81.47 |
mg/dl |
5.41 |
16.22 |
plasma total cholesterol measurement test |
|
0.0 |
|
|
|
|
|
102635 |
3014 |
| LN/MavRrrcAek |
plasma total cholesterol level |
standard rat chow (for 98 days) then controlled sodium chloride content diet (4 %) (for 28 days) |
Wang J, et al., Circ Cardiovasc Genet. 2015 Apr;8(2):316-26. doi: 10.1161/CIRCGENETICS.114.000520. Epub 2015 Jan 8. |
blood cholesterol amount |
male |
126.0 days
| 14 |
|
|
71.81 |
mg/dl |
6.56 |
24.56 |
plasma total cholesterol measurement test |
|
0.0 |
|
|
|
|
|
102636 |
3014 |
| SS.BN-(D13Hmgc1048-D13Hmgc1050)/Mcwi |
diastolic blood pressure |
controlled sodium chloride content diet (0.4 %) (between 23 and 32 days) then controlled sodium chloride content diet (8 %) (for 14 days) |
Cowley AW Jr, et al., Physiol Genomics. 2016 Jan;48(1):62-72. doi: 10.1152/physiolgenomics.00097.2015. Epub 2015 Nov 3. |
arterial blood pressure trait |
male |
58.0 days-67.0 days |
11 |
|
serial mean |
120.0 |
mmHg |
4.0 |
13.27 |
intra-aortic thoracic radiotelemetry via carotid cannulation |
|
10800.0 |
|
|
carotid a. to thoracic aorta implant |
strain 26-P |
|
98510 |
2079 |
| SS.BN-(D13Hmgc37-D13Got22)/Mcwi |
mean arterial blood pressure |
controlled sodium chloride content diet (0.4 %) (for 68 days) then controlled sodium chloride content diet (8 %) (for 21 days) |
Moreno C, et al., Am J Physiol Heart Circ Physiol. 2011 Apr;300(4):H1530-5. doi: 10.1152/ajpheart.01026.2010. Epub 2011 Jan 21. |
arterial blood pressure trait |
male |
89.0 days
| 15 |
|
serial mean |
162.0 |
mmHg |
4.0 |
15.49 |
intra-aortic abdominal radiotelemetry via femoral cannulation |
|
10800.0 |
|
|
|
strain 5-1 |
|
98674 |
2138 |
| SS/JrHsdMcwi |
urine albumin excretion rate |
controlled sodium chloride content diet (0.4 %) (for 70 days) then controlled sodium chloride content diet (8 %) (for 21 days) |
Hoffman MJ, et al., Hypertension. 2013 Sep;62(3):557-63. doi: 10.1161/HYPERTENSIONAHA.113.01708. Epub 2013 Jul 1. |
urine albumin amount |
female |
91.0 days
| 13 |
|
|
135.0 |
mg/d |
15.0 |
54.08 |
urine microalbumin analysis |
|
1.0 |
|
|
|
|
|
98710 |
2141 |
| SS.BN-(D13Rat25-rs106935835)/Mcwi |
urine albumin excretion rate |
controlled sodium chloride content diet (0.4 %) (for 70 days) then controlled sodium chloride content diet (8 %) (for 21 days) |
Hoffman MJ, et al., Hypertension. 2013 Sep;62(3):557-63. doi: 10.1161/HYPERTENSIONAHA.113.01708. Epub 2013 Jul 1. |
urine albumin amount |
male |
91.0 days
| 11 |
|
|
343.0 |
mg/d |
41.0 |
135.98 |
urine microalbumin analysis |
|
1.0 |
|
|
|
strain 9E |
|
98715 |
2141 |
| SS/Jr |
heart weight to body weight ratio |
controlled sodium chloride content diet (8 %) (for 35 days) |
Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. |
heart mass |
male |
63.0 days
| 10 |
|
|
3.1 |
g/kg |
0.06 |
0.19 |
post excision weight measurement |
|
0.0 |
|
|
|
|
|
103241 |
2802 |
| SR/Jr |
single kidney wet weight to body weight ratio |
controlled sodium chloride content diet (0.3 %) (for 35 days) |
Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. |
kidney mass |
male |
63.0 days
| 16 |
|
|
7.24 |
g/kg |
0.1 |
0.4 |
post excision weight measurement |
|
0.0 |
|
|
|
|
|
103242 |
2802 |
| SS/Jr |
systolic blood pressure |
controlled sodium chloride content diet (0.3 %) (for 35 days) |
Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. |
arterial blood pressure trait |
male |
63.0 days
| 15 |
|
|
159.0 |
mmHg |
3.0 |
11.62 |
vascular transducer tipped catheter |
|
0.0 |
|
|
|
|
|
103248 |
2802 |
| SR/Jr |
diastolic blood pressure |
controlled sodium chloride content diet (0.3 %) (for 35 days) |
Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. |
arterial blood pressure trait |
male |
63.0 days
| 16 |
|
|
91.0 |
mmHg |
3.0 |
12.0 |
vascular transducer tipped catheter |
|
0.0 |
|
|
|
|
|
103254 |
2802 |
| SS/Jr |
diastolic blood pressure |
controlled sodium chloride content diet (8 %) (for 35 days) |
Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. |
arterial blood pressure trait |
male |
63.0 days
| 10 |
|
|
124.0 |
mmHg |
6.0 |
18.97 |
vascular transducer tipped catheter |
|
0.0 |
|
|
|
|
|
103257 |
2802 |
| SR/Jr |
plasma total cholesterol level |
controlled sodium chloride content diet (8 %) (for 35 days) |
Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. |
blood cholesterol amount |
male |
63.0 days
| 13 |
|
|
72.59 |
mg/dl |
2.7 |
9.74 |
plasma total cholesterol measurement test |
|
0.0 |
|
|
|
|
|
103263 |
2802 |
| SS/Jr |
red blood cell sodium level |
controlled sodium chloride content diet (0.3 %) (for 35 days) |
Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. |
erythrocyte sodium amount |
male |
63.0 days
| 15 |
|
|
3.5 |
mmol/l |
0.05 |
0.19 |
ex vivo blood analysis |
|
0.0 |
|
|
|
|
|
103276 |
2802 |
| SS-Renem1Mcwi+/- |
systolic blood pressure |
controlled sodium chloride content diet (0.4 %) (between 66 and 69 days) |
Moreno C, et al., Hypertension. 2011 Mar;57(3):614-9. doi: 10.1161/HYPERTENSIONAHA.110.163840. Epub 2011 Jan 17. |
arterial blood pressure trait |
male |
66.0 days-69.0 days |
9 |
|
serial mean |
144.19 |
mmHg |
2.22 |
6.66 |
intra-aortic abdominal radiotelemetry |
|
32400.0 |
|
|
|
|
|
98376 |
2038 |
| SS-Renem1Mcwi-/- |
mean arterial blood pressure |
controlled sodium chloride content diet (0.4 %) (between 66 and 69 days) |
Moreno C, et al., Hypertension. 2011 Mar;57(3):614-9. doi: 10.1161/HYPERTENSIONAHA.110.163840. Epub 2011 Jan 17. |
arterial blood pressure trait |
male |
66.0 days-69.0 days |
8 |
|
serial mean |
58.36 |
mmHg |
2.38 |
6.73 |
intra-aortic abdominal radiotelemetry |
|
32400.0 |
|
|
|
|
|
98380 |
2038 |
| SS/JrHsdMcwi |
mean arterial blood pressure |
controlled sodium chloride content diet (0.4 %) (between 46 and 50.8 days) then controlled sodium chloride content diet (8 %) (for 13.4 days) |
Cowley AW, et al., Physiol Genomics. 2014 Jun 1;46(11):398-410. doi: 10.1152/physiolgenomics.00179.2013. Epub 2014 Apr 8. |
arterial blood pressure trait |
male |
60.0 days-67.0 days |
12 |
|
serial mean |
177.0 |
mmHg |
4.0 |
13.86 |
intra-aortic thoracic radiotelemetry via carotid cannulation |
|
10800.0 |
|
|
intra-carotid radiotelemetry |
|
|
98551 |
2098 |
| SS-Nppbem2Mcwi-/- |
ejection fraction |
controlled sodium chloride content diet (for 21 days) |
Holditch SJ, et al., Hypertension. 2015 Jul;66(1):199-210. doi: 10.1161/HYPERTENSIONAHA.115.05610. Epub 2015 May 11. |
cardiac output trait |
male |
98.0 days
| 4 |
|
|
83.0 |
% |
1.41 |
2.82 |
echocardiography |
|
0.0 |
|
|
|
|
|
99723 |
2319 |
| SS-Nppbem2Mcwi+/+ |
heart left ventricle weight |
controlled sodium chloride content diet (for 21 days) |
Holditch SJ, et al., Hypertension. 2015 Jul;66(1):199-210. doi: 10.1161/HYPERTENSIONAHA.115.05610. Epub 2015 May 11. |
heart left ventricle mass |
male |
98.0 days
| 4 |
|
|
1.47 |
g |
0.11 |
0.22 |
echocardiography |
|
0.0 |
|
|
|
|
|
99726 |
2319 |
| SS-Nppbem2Mcwi-/- |
heart left ventricle weight |
controlled sodium chloride content diet (for 21 days) |
Holditch SJ, et al., Hypertension. 2015 Jul;66(1):199-210. doi: 10.1161/HYPERTENSIONAHA.115.05610. Epub 2015 May 11. |
heart left ventricle mass |
male |
98.0 days
| 4 |
|
|
1.53 |
g |
0.09 |
0.18 |
echocardiography |
|
0.0 |
|
|
|
|
|
99727 |
2319 |
| SS-Nppbem2Mcwi-/- |
heart rate |
controlled sodium chloride content diet (for 21 days) |
Holditch SJ, et al., Hypertension. 2015 Jul;66(1):199-210. doi: 10.1161/HYPERTENSIONAHA.115.05610. Epub 2015 May 11. |
heart pumping trait |
male |
98.0 days
| 4 |
|
|
421.0 |
beats/min |
4.0 |
8.0 |
echocardiography |
|
0.0 |
|
|
|
|
|
99729 |
2319 |
| SS |
urine urotensin II level to urine creatinine level ratio |
controlled sodium chloride content diet (8 %) (for 28 days) |
Wu F, et al., Int J Hypertens. 2016;2016:9146870. doi: 10.1155/2016/9146870. Epub 2016 Dec 19. |
urine urotensin II amount |
male |
77.0 days
| 8 |
|
|
136.7 |
ng/g |
16.05 |
45.4 |
radioimmunoassay |
|
0.0 |
|
|
|
|
|
102278 |
2683 |
| SR/NEisSlc |
body weight |
controlled sodium chloride content diet (8 %) (for 7 days) |
Yoshihara F, et al., Regul Pept. 2005 May 15;128(1):7-13. |
body mass |
male |
63.0 days
| 7 |
|
|
286.0 |
g |
6.05 |
16.0 |
body weighing method |
|
0.0 |
|
|
|
|
|
102405 |
2689 |
| SR/NEisSlc |
heart rate |
controlled sodium chloride content diet (8 %) (for 7 days) |
Yoshihara F, et al., Regul Pept. 2005 May 15;128(1):7-13. |
heart pumping trait |
male |
63.0 days
| 7 |
|
|
389.0 |
beats/min |
9.07 |
24.0 |
tail cuff plethysmography |
|
0.0 |
|
|
|
|
|
102411 |
2689 |
| SR/NEisSlc |
heart rate |
controlled sodium chloride content diet (8 %) (for 21 days) |
Yoshihara F, et al., Regul Pept. 2005 May 15;128(1):7-13. |
heart pumping trait |
male |
77.0 days
| 7 |
|
|
377.0 |
beats/min |
8.32 |
22.0 |
tail cuff plethysmography |
|
0.0 |
|
|
|
|
|
102415 |
2689 |
| SS/NEisSlc |
heart rate |
controlled sodium chloride content diet (8 %) (for 14 days) |
Yoshihara F, et al., Regul Pept. 2005 May 15;128(1):7-13. |
heart pumping trait |
male |
70.0 days
| 7 |
|
|
373.0 |
beats/min |
3.78 |
10.0 |
tail cuff plethysmography |
|
0.0 |
|
|
|
|
|
102414 |
2689 |
| SR/NEisSlc |
heart left ventricle plus septum weight to body weight ratio |
controlled sodium chloride content diet (8 %) (for 14 days) |
Yoshihara F, et al., Regul Pept. 2005 May 15;128(1):7-13. |
heart left ventricle mass |
male |
70.0 days
| 8 |
|
|
2.22 |
mg/g |
0.06 |
0.16 |
post excision weight measurement |
|
0.0 |
|
|
|
heart left ventricle plus septum weight to body weight ratio (CMO:0003869) |
|
102419 |
2689 |
| SS/NEisSlc |
heart left ventricle plus septum weight to body weight ratio |
controlled sodium chloride content diet (8 %) (for 21 days) |
Yoshihara F, et al., Regul Pept. 2005 May 15;128(1):7-13. |
heart left ventricle mass |
male |
77.0 days
| 8 |
|
|
2.58 |
mg/g |
0.05 |
0.13 |
post excision weight measurement |
|
0.0 |
|
|
|
heart left ventricle plus septum weight to body weight ratio (CMO:0003869) |
|
102422 |
2689 |
| SS/NEisSlc |
heart left ventricle plus septum weight to body weight ratio |
controlled sodium chloride content diet (8 %) (for 14 days) |
Yoshihara F, et al., Regul Pept. 2005 May 15;128(1):7-13. |
heart left ventricle mass |
male |
70.0 days
| 7 |
|
|
2.42 |
mg/g |
0.03 |
0.07 |
post excision weight measurement |
|
0.0 |
|
|
|
heart left ventricle plus septum weight to body weight ratio (CMO:0003869) |
|
102420 |
2689 |
| SS/NEisSlc |
single kidney wet weight to body weight ratio |
controlled sodium chloride content diet (8 %) (for 21 days) |
Yoshihara F, et al., Regul Pept. 2005 May 15;128(1):7-13. |
kidney mass |
male |
77.0 days
| 8 |
|
|
4.64 |
g/kg |
0.07 |
0.19 |
post excision weight measurement |
|
0.0 |
|
|
|
|
|
102428 |
2689 |
| SS/NEisSlc |
single kidney wet weight to body weight ratio |
controlled sodium chloride content diet (8 %) (for 14 days) |
Yoshihara F, et al., Regul Pept. 2005 May 15;128(1):7-13. |
kidney mass |
male |
70.0 days
| 7 |
|
|
4.46 |
g/kg |
0.08 |
0.2 |
post excision weight measurement |
|
0.0 |
|
|
|
|
|
102426 |
2689 |
| SR/NEisSlc |
systolic blood pressure |
controlled sodium chloride content diet (8 %) (for 7 days) |
Yoshihara F, et al., Regul Pept. 2005 May 15;128(1):7-13. |
arterial blood pressure trait |
male |
63.0 days
| 7 |
mean of 3 samples of undefined duration |
serial mean |
119.0 |
mmHg |
3.02 |
8.0 |
tail cuff plethysmography |
|
0.0 |
|
|
|
|
|
102429 |
2689 |
| SS/NEisSlc |
systolic blood pressure |
controlled sodium chloride content diet (8 %) (for 21 days) |
Yoshihara F, et al., Regul Pept. 2005 May 15;128(1):7-13. |
arterial blood pressure trait |
male |
77.0 days
| 8 |
mean of 3 samples of undefined duration |
serial mean |
169.0 |
mmHg |
2.47 |
7.0 |
tail cuff plethysmography |
|
0.0 |
|
|
|
|
|
102434 |
2689 |
| SS/NEisSlc |
systolic blood pressure |
controlled sodium chloride content diet (8 %) (for 14 days) |
Yoshihara F, et al., Regul Pept. 2005 May 15;128(1):7-13. |
arterial blood pressure trait |
male |
70.0 days
| 7 |
mean of 3 samples of undefined duration |
serial mean |
166.0 |
mmHg |
1.89 |
5.0 |
tail cuff plethysmography |
|
0.0 |
|
|
|
|
|
102432 |
2689 |
| SS/NEisSlc |
urine sodium excretion rate |
controlled sodium chloride content diet (8 %) (for 14 days) |
Yoshihara F, et al., Regul Pept. 2005 May 15;128(1):7-13. |
urine sodium amount |
male |
70.0 days
| 7 |
|
|
1.9 |
mEq/d |
0.34 |
0.9 |
automated urine sodium analysis |
|
0.0 |
|
|
|
|
|
102438 |
2689 |
| SS/NEisSlc |
urine total protein excretion rate to body weight ratio |
controlled sodium chloride content diet (8 %) (for 21 days) then 0.9% sodium chloride solution (for 21 days) |
Yoshihara F, et al., Regul Pept. 2005 May 15;128(1):7-13. |
total urine protein amount |
male |
77.0 days
| 14 |
|
|
7.8 |
mg/d/100 g |
0.72 |
2.7 |
urine protein analysis |
|
0.0 |
|
|
|
|
|
102478 |
2689 |
| SS/Jr |
body weight |
controlled sodium chloride content diet (0.3 %) (for 35 days) |
Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. |
body mass |
male |
63.0 days
| 15 |
|
|
271.0 |
g |
10.0 |
38.73 |
body weighing method |
|
0.0 |
|
|
|
|
|
103236 |
2802 |
| SR/JrHsd |
adrenal angiotensin II type 1 receptor density |
controlled sodium chloride content diet (4 %) (for 14 days) then bilateral ovariectomy then 17 beta-estradiol (10 ug/d) (for 14 days) |
Zheng W, et al., Am J Physiol Heart Circ Physiol. 2008 Apr;294(4):H1508-13. doi: 10.1152/ajpheart.01322.2007. Epub 2008 Feb 1. |
adrenal gland molecular composition trait |
female |
days
| |
|
|
94.8 |
fmol/mg |
9.2 |
|
radioimmunoassay |
|
0.0 |
|
|
|
|
|
102228 |
2681 |
| SD-Nfe2l2em1Mcwi-/- |
body weight |
controlled sodium chloride content diet (0.4 %) (between 70 and 84 days) then controlled sodium chloride content diet (4 %) (for 3 days) then 0.9% sodium chloride solution (for 3 days) |
Priestley JR, et al., Am J Physiol Heart Circ Physiol. 2016 Feb 15;310(4):H478-87. doi: 10.1152/ajpheart.00586.2015. Epub 2015 Dec 4. |
body mass |
male |
62.0 days-76.0 days |
4 |
|
|
299.0 |
g |
22.2 |
44.4 |
body weighing method |
|
0.0 |
|
|
|
|
|
100734 |
2520 |
| SS-Plekha7em4Mcwi+/+ |
nephron count |
controlled sodium chloride content diet (8 %) (for 28 days) |
Endres BT, et al., Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):12817-22. doi: 10.1073/pnas.1410745111. Epub 2014 Aug 18. |
nephron morphology trait |
male |
91.0 days
| 10 |
|
|
33450.0 |
null |
208.0 |
657.75 |
ex vivo light microscopy with histochemistry and digital image analysis |
|
0.0 |
|
|
|
nephron count |
|
105751 |
3022 |
| LH/MavRrrcAek |
plasma leptin level |
standard rat chow (for 98 days) then controlled sodium chloride content diet (4 %) (for 28 days) |
Wang J, et al., Circ Cardiovasc Genet. 2015 Apr;8(2):316-26. doi: 10.1161/CIRCGENETICS.114.000520. Epub 2015 Jan 8. |
blood leptin amount |
male |
126.0 days
| 13 |
|
|
1.68 |
ng/ml |
0.34 |
1.21 |
plasma leptin analysis |
|
|
|
|
automated plasma leptin analysis |
|
|
105321 |
3014 |
| SS-Chr 2BN/Mcwi |
renal afferent arteriole diameter |
controlled sodium chloride content diet (1 %) (between 70 and 91 days) then controlled ex vivo artery perfusion pressure (60 mmHg) (for 0.1 hours) |
Miller B, et al., J Clin Invest. 2016 Jul 1;126(7):2533-46. doi: 10.1172/JCI75079. Epub 2016 Jun 6. |
kidney arteriole morphology trait |
not specified |
91.0 days-133.0 days |
6 |
|
|
20.8 |
um |
1.0 |
2.45 |
ex vivo videomicroscopy |
renal afferent arteriole |
120.0 |
|
|
ex vivo videomicroscopy (MMO:0000319) |
renal afferent arteriole diameter (CMO:0003725) |
renal arteriole morphology trait |
106500 |
3030 |
| SS-Shc1em4Mcwi |
renal afferent arteriole diameter |
controlled sodium chloride content diet (1 %) (between 70 and 91 days) then controlled ex vivo artery perfusion pressure (60 mmHg) (for 0.1 hours) |
Miller B, et al., J Clin Invest. 2016 Jul 1;126(7):2533-46. doi: 10.1172/JCI75079. Epub 2016 Jun 6. |
kidney arteriole morphology trait |
not specified |
91.0 days-133.0 days |
4 |
|
|
24.1 |
um |
2.4 |
4.8 |
ex vivo videomicroscopy |
renal afferent arteriole |
120.0 |
|
|
ex vivo videomicroscopy (MMO:0000319) |
renal afferent arteriole diameter (CMO:0003725) |
renal arteriole morphology trait |
106502 |
3030 |
| SS-Shc1em4Mcwi |
renal afferent arteriole diameter |
controlled sodium chloride content diet (1 %) (between 70 and 91 days) then controlled ex vivo artery perfusion pressure (60 mmHg) (for 0.1 hours) |
Miller B, et al., J Clin Invest. 2016 Jul 1;126(7):2533-46. doi: 10.1172/JCI75079. Epub 2016 Jun 6. |
kidney arteriole morphology trait |
not specified |
91.0 days-133.0 days |
7 |
|
|
23.9 |
um |
1.6 |
4.23 |
ex vivo videomicroscopy |
renal afferent arteriole |
120.0 |
|
|
ex vivo videomicroscopy (MMO:0000319) |
renal afferent arteriole diameter (CMO:0003725) |
renal arteriole morphology trait |
106506 |
3030 |
| SS-Shc1em5Mcwi |
renal afferent arteriole diameter |
controlled sodium chloride content diet (1 %) (between 70 and 91 days) then controlled ex vivo artery perfusion pressure (60 mmHg) (for 0.1 hours) |
Miller B, et al., J Clin Invest. 2016 Jul 1;126(7):2533-46. doi: 10.1172/JCI75079. Epub 2016 Jun 6. |
kidney arteriole morphology trait |
not specified |
91.0 days-133.0 days |
8 |
|
|
24.5 |
um |
1.5 |
4.24 |
ex vivo videomicroscopy |
renal afferent arteriole |
120.0 |
|
|
ex vivo videomicroscopy (MMO:0000319) |
renal afferent arteriole diameter (CMO:0003725) |
renal arteriole morphology trait |
106507 |
3030 |
| SS-Sh2b3em1Mcwi-/- |
spleen regulatory T cell count to total T cell count ratio |
controlled sodium chloride content diet (0.4 %) (for 42 days) |
Rudemiller NP, et al., Hypertension. 2015 May;65(5):1111-7. doi: 10.1161/HYPERTENSIONAHA.114.04736. Epub 2015 Mar 16. |
T cell quantity |
not specified |
63.0 days
| 4 |
|
|
5.2 |
% |
0.3 |
0.6 |
flow cytometry method |
|
0.0 |
|
|
|
n=4-7 -tregs blood % |
|
106517 |
3031 |
| SS/JrHsdMcwi |
spleen regulatory T cell count to total T cell count ratio |
controlled sodium chloride content diet (0.4 %) (for 42 days) |
Rudemiller NP, et al., Hypertension. 2015 May;65(5):1111-7. doi: 10.1161/HYPERTENSIONAHA.114.04736. Epub 2015 Mar 16. |
T cell quantity |
not specified |
63.0 days
| 4 |
|
|
3.5 |
% |
0.1 |
0.2 |
flow cytometry method |
|
0.0 |
|
|
|
n=4-7 -tregs blood % |
|
106516 |
3031 |
| SS-Sh2b3em1Mcwi-/- |
mean arterial blood pressure |
controlled sodium chloride content diet (0.4 %) (for 70 days) |
Rudemiller NP, et al., Hypertension. 2015 May;65(5):1111-7. doi: 10.1161/HYPERTENSIONAHA.114.04736. Epub 2015 Mar 16. |
arterial blood pressure trait |
not specified |
70.0 days
| 6 |
15sec/min for 3 hrs/day for 7days |
|
127.7 |
mmHg |
2.0 |
4.9 |
vascular fluid filled catheter |
|
0.0 |
|
|
|
n=6-8 |
|
106521 |
3031 |
| SS-Sh2b3em1Mcwi-/- |
mean arterial blood pressure |
controlled sodium chloride content diet (0.4 %) (for 70 days) then controlled sodium chloride content diet (4 %) (for 21 days) |
Rudemiller NP, et al., Hypertension. 2015 May;65(5):1111-7. doi: 10.1161/HYPERTENSIONAHA.114.04736. Epub 2015 Mar 16. |
arterial blood pressure trait |
not specified |
91.0 days
| 6 |
15sec/min for 3 hrs/day |
|
135.7 |
mmHg |
1.1 |
2.69 |
vascular fluid filled catheter |
|
0.0 |
|
|
|
n=6-8 |
|
106523 |
3031 |
| SS-Sh2b3em1Mcwi-/- |
urine albumin excretion rate |
controlled sodium chloride content diet (0.4 %) (for 42 days) then controlled sodium chloride content diet (4 %) (for 10 days) |
Rudemiller NP, et al., Hypertension. 2015 May;65(5):1111-7. doi: 10.1161/HYPERTENSIONAHA.114.04736. Epub 2015 Mar 16. |
urine albumin amount |
not specified |
73.0 days
| 6 |
|
|
9.4 |
mg/d |
2.4 |
5.88 |
urine albumin analysis |
|
0.0 |
|
|
|
n=6-8 |
|
106527 |
3031 |
| SS/JrHsdMcwi |
urine albumin excretion rate |
controlled sodium chloride content diet (0.4 %) (for 42 days) then controlled sodium chloride content diet (4 %) (for 10 days) |
Rudemiller NP, et al., Hypertension. 2015 May;65(5):1111-7. doi: 10.1161/HYPERTENSIONAHA.114.04736. Epub 2015 Mar 16. |
urine albumin amount |
not specified |
73.0 days
| 6 |
|
|
101.1 |
mg/d |
15.4 |
37.72 |
urine albumin analysis |
|
0.0 |
|
|
|
n=6-8 |
|
106526 |
3031 |
| SS/JrHsdMcwi |
kidney total CD3 positive T cell count |
controlled sodium chloride content diet (0.4 %) (for 84 days) |
Rudemiller NP, et al., Hypertension. 2015 May;65(5):1111-7. doi: 10.1161/HYPERTENSIONAHA.114.04736. Epub 2015 Mar 16. |
T cell quantity |
not specified |
84.0 days
| 5 |
|
|
0.21 |
x 10E6 cells/ml |
0.03 |
0.07 |
flow cytometry method |
|
0.0 |
|
|
|
n=5-6 (tissue T cell count) |
|
106533 |
3031 |
| SS/JrHsdMcwi |
kidney total CD45 positive leukocyte count |
controlled sodium chloride content diet (0.4 %) (for 21 days) then controlled sodium chloride content diet (4 %) (for 21 days) |
Rudemiller NP, et al., Hypertension. 2015 May;65(5):1111-7. doi: 10.1161/HYPERTENSIONAHA.114.04736. Epub 2015 Mar 16. |
leukocyte quantity |
not specified |
84.0 days
| 5 |
|
|
3.92 |
x 10E6 cells/ml |
0.42 |
0.94 |
flow cytometry method |
|
0.0 |
|
|
|
n=5-6 |
|
106535 |
3031 |
| SS/HsdMcwiCrl |
mean arterial blood pressure |
controlled sodium chloride content diet (0.1 %) (between 28 and 42 days) |
Gabor A and Leenen FH, Brain Res. 2012 Apr 4;1447:28-37. doi: 10.1016/j.brainres.2012.01.060. Epub 2012 Feb 1. |
arterial blood pressure trait |
male |
77.0 days-98.0 days |
4 |
MAP=.33(SP-DP) + DP |
|
109.0 |
mmHg |
3.0 |
6.0 |
vascular fluid filled catheter |
femoral artery |
600.0 |
|
|
|
|
|
106756 |
2685 |
| SBH/Ygl |
systolic blood pressure |
controlled sodium chloride content diet (0.65 %) (for 98 days) then streptozotocin (60 mg/kg) then insulin (10 ul) (for 42 days) |
Landau D, et al., J Endocrinol. 2008 Apr;197(1):75-83. doi: 10.1677/JOE-08-0040. |
arterial blood pressure trait |
male |
98.0 days
| 7 |
|
|
128.0 |
mmHg |
2.0 |
5.29 |
tail cuff plethysmography |
|
0.0 |
|
|
|
|
|
106698 |
3038 |
| SBH/Ygl |
food intake weight to body weight ratio |
controlled sodium chloride content diet (8 %) (for 28 days) |
Landau D, et al., J Endocrinol. 2008 Apr;197(1):75-83. doi: 10.1677/JOE-08-0040. |
eating behavior trait |
male |
84.0 days
| 7 |
|
|
10.53 |
g/d/100g |
0.65 |
1.72 |
food intake measuring method |
|
0.0 |
|
|
|
|
|
106705 |
3038 |
| SBH/Ygl |
food intake weight to body weight ratio |
controlled sodium chloride content diet (8 %) (for 28 days) then streptozotocin (60 mg/kg) then insulin (10 ul) (for 28 days) |
Landau D, et al., J Endocrinol. 2008 Apr;197(1):75-83. doi: 10.1677/JOE-08-0040. |
eating behavior trait |
male |
84.0 days
| 7 |
|
|
15.72 |
g/d/100g |
0.7 |
1.85 |
food intake measuring method |
|
0.0 |
|
|
|
|
|
106707 |
3038 |
| SBH/Ygl |
heart left ventricle fractional shortening |
controlled sodium chloride content diet (8 %) (for 42 days) |
Landau D, et al., J Endocrinol. 2008 Apr;197(1):75-83. doi: 10.1677/JOE-08-0040. |
heart left ventricle end-diastolic diameter |
male |
98.0 days
| 7 |
|
|
64.0 |
% |
2.0 |
5.29 |
transthoracic echocardiography |
|
0.0 |
|
|
|
|
|
106713 |
3038 |
| SBH/Ygl |
heart weight |
controlled sodium chloride content diet (8 %) (for 42 days) then streptozotocin (60 mg/kg) then insulin (10 ul) (for 42 days) |
Landau D, et al., J Endocrinol. 2008 Apr;197(1):75-83. doi: 10.1677/JOE-08-0040. |
heart mass |
male |
98.0 days
| 7 |
|
|
1.03 |
g |
0.08 |
0.2 |
post excision weight measurement |
|
0.0 |
|
|
|
|
|
106711 |
3038 |
| SS/Jr |
maximum rate of positive change in left ventricular blood pressure to left ventricular systolic blood pressure ratio |
controlled sodium chloride content diet (0.3 %) (for 21 days) then controlled sodium chloride content diet (8 %) (for 42 days) then pentobarbital, sodium (20 mg/kg) |
Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. |
heart left ventricular blood pressure trait |
not specified |
84.0 days
| 5 |
LVdP/dtmax/P |
|
73.0 |
/s |
4.47 |
13.0 |
vascular transducer tipped catheter |
|
0.0 |
|
|
|
maximum rate of positive change in left ventricular blood pressure to left ventricular systolic blood pressure ratio maximum rate of positive change in left ventricular blood pressure to left ventricular systolic blood pressure ratio |
|
106815 |
2787 |
| SBH/Ygl |
blood glucose level |
controlled sodium chloride content diet (0.65 %) (for 98 days) then streptozotocin (60 mg/kg) then insulin (10 ul) (for 42 days) |
Landau D, et al., J Endocrinol. 2008 Apr;197(1):75-83. doi: 10.1677/JOE-08-0040. |
blood glucose amount |
male |
98.0 days
| 7 |
|
|
383.4 |
mg/dl |
21.6 |
57.15 |
blood glucose test strip read by electrochemical glucometer |
|
0.0 |
|
|
|
|
|
106694 |
3038 |
| SR/Jr |
ouabain-sensitive red blood cell Na+ export rate |
controlled sodium chloride content diet (0.3 %) (for 35 days) |
Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. |
erythrocyte ion transport trait |
male |
63.0 days
| 16 |
|
|
3500.0 |
umol/l/h |
91.0 |
200.0 |
Na+/K+ ATPase activity assay |
|
0.0 |
|
|
|
|
|
110981 |
2802 |
| SR/Jr |
bumetanide-sensitive red blood cell Na+ export rate |
controlled sodium chloride content diet (0.3 %) (for 35 days) |
Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. |
erythrocyte ion transport trait |
male |
63.0 days
| 16 |
|
|
163.0 |
umol/l/h |
70.0 |
280.0 |
Na-K-Cl cotransport activity assay |
|
0.0 |
|
|
|
|
|
111037 |
2802 |
| SR/Jr |
ouabain- and bumetanide-resistant red blood cell Na+ import rate |
controlled sodium chloride content diet (0.3 %) (for 35 days) |
Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. |
erythrocyte ion transport trait |
male |
63.0 days
| 16 |
|
|
3586.0 |
umol/l/h |
110.0 |
440.0 |
Na+ passive permeability assay |
|
0.0 |
|
|
|
|
|
111041 |
2802 |
| SR/Jr |
bumetanide-sensitive red blood cell K+ import rate |
controlled sodium chloride content diet (0.3 %) (for 35 days) |
Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. |
erythrocyte ion transport trait |
male |
63.0 days
| 16 |
|
|
773.0 |
umol/l/h |
61.0 |
244.0 |
Na-K-Cl cotransport activity assay |
|
0.0 |
|
|
|
|
|
111049 |
2802 |
| SR/Jr |
ouabain- and bumetanide-resistant red blood cell K+ import rate |
controlled sodium chloride content diet (0.3 %) (for 35 days) |
Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. |
erythrocyte ion transport trait |
male |
63.0 days
| 16 |
|
|
382.0 |
umol/l/h |
13.0 |
52.0 |
Na+ passive permeability assay |
|
0.0 |
|
|
|
|
|
111053 |
2802 |
| MWF/Fub |
kidney wet weight to body weight ratio |
controlled sodium chloride content diet (8 %) (for 56 days) |
Kreutz R, etal., J Hypertens. 2000 Jun;18(6):777-82. doi: 10.1097/00004872-200018060-00017. |
kidney mass |
female |
104.0 days
| 8 |
|
|
3.69 |
mg/g |
0.07 |
0.2 |
post excision weight measurement |
kidney |
0.0 |
|
|
|
|
|
109018 |
3134 |
| BN.GH-(D2Rat22-D2Mgh11)(D18Rat41-D18Mgh4)/Mcwi |
mean arterial blood pressure |
controlled sodium chloride content diet (0.4 %) (for 3 days) then controlled sodium chloride content diet (4 %) (for 23 days) |
Bilusic M, et al., Croat Med J. 2008 Oct;49(5):586-99. |
arterial blood pressure trait |
male |
155.0 days-169.0 days |
16 |
|
serial mean |
110.1 |
mmHg |
1.95 |
7.8 |
radiotelemetry |
left femoral artery |
10 seconds every two minutes for 4 hrs/day every other day for 23 days |
|
|
Dataquest IV system; anesthetized by 1% isoflurane, recover for 3 days |
|
|
11559 |
101 |
| SS/Jr |
left ventricular systolic blood pressure |
controlled sodium chloride content diet (0.3 %) (for 21 days) then controlled sodium chloride content diet (8 %) (for 42 days) then pentobarbital, sodium (20 mg/kg) |
Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. |
heart left ventricular blood pressure trait |
not specified |
84.0 days
| 5 |
|
|
180.0 |
mmHg |
4.47 |
10.0 |
vascular transducer tipped catheter |
|
0.0 |
|
|
|
|
|
103149 |
2787 |
| SS/Jr |
heart rate |
controlled sodium chloride content diet (0.3 %) (for 21 days) then controlled sodium chloride content diet (8 %) (for 42 days) then 10% CO2, 20% O2, 70% N2 (for 0.4 hours) then ambient air (between 0 and 0.1 hours) |
Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. |
heart pumping trait |
not specified |
86.0 days
| 5 |
sampling once per minute |
|
479.0 |
beats/min |
10.73 |
24.0 |
intra-aortic thoracic radiotelemetry |
|
0.0 |
5 |
min |
|
|
|
103161 |
2787 |
| SR/Jr |
mean arterial blood pressure |
controlled sodium chloride content diet (0.3 %) (for 21 days) then controlled sodium chloride content diet (8 %) (for 42 days) then ambient air (between 0 and 0.1 hours) |
Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. |
arterial blood pressure trait |
not specified |
86.0 days
| 5 |
sampling once per minute |
|
102.0 |
mmHg |
0.45 |
1.0 |
intra-aortic thoracic radiotelemetry |
|
0.0 |
|
|
|
|
|
103166 |
2787 |
| SR/Jr |
mean arterial blood pressure |
controlled sodium chloride content diet (0.3 %) (for 42 days) then controlled sodium chloride content diet (8 %) (for 42 days) then 10% CO2, 20% O2, 70% N2 (between 0 and 0.4 hours) then ambient air (between 0 and 0.1 hours) |
Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. |
arterial blood pressure trait |
not specified |
86.0 days
| 5 |
sampling once per minute |
|
103.0 |
mmHg |
0.45 |
1.0 |
intra-aortic thoracic radiotelemetry |
|
0.0 |
|
|
|
|
|
103172 |
2787 |
| SR/Jr |
mean arterial blood pressure |
controlled sodium chloride content diet (0.3 %) (for 42 days) then controlled sodium chloride content diet (8 %) (for 42 days) then 10% CO2, 20% O2, 70% N2 (between 0 and 0.4 hours) then ambient air (between 0 and 0.4 hours) |
Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. |
arterial blood pressure trait |
not specified |
86.0 days
| 5 |
sampling once per minute |
|
101.0 |
mmHg |
0.89 |
2.0 |
intra-aortic thoracic radiotelemetry |
|
0.0 |
|
|
|
|
|
103174 |
2787 |
| SR/Jr |
heart rate |
controlled sodium chloride content diet (0.3 %) (for 21 days) then controlled sodium chloride content diet (8 %) (for 42 days) then atropine (1 mg/kg) (between 0.9 and 1 hours) then 10% CO2, 20% O2, 70% N2 (for 0.4 hours) then ambient air (between 0 and 0.1 hours) |
Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. |
heart pumping trait |
not specified |
86.0 days
| 5 |
sampling once per minute |
|
472.0 |
beats/min |
4.47 |
10.0 |
intra-aortic thoracic radiotelemetry |
|
0.0 |
25 |
min |
|
|
|
103195 |
2787 |
| SR/Jr |
heart rate |
controlled sodium chloride content diet (0.3 %) (for 21 days) then controlled sodium chloride content diet (8 %) (for 42 days) then atropine (1 mg/kg) (between 0.9 and 1.3 hours) then 10% CO2, 20% O2, 70% N2 (for 0.4 hours) then ambient air (between 0 and 0.4 hours) |
Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. |
heart pumping trait |
not specified |
86.0 days
| 5 |
sampling once per minute |
|
463.0 |
beats/min |
1.79 |
4.0 |
intra-aortic thoracic radiotelemetry |
|
0.0 |
25 |
min |
|
|
|
103197 |
2787 |
| SS/Jr |
mean arterial blood pressure |
controlled sodium chloride content diet (0.3 %) (for 42 days) then controlled sodium chloride content diet (8 %) (for 42 days) then atropine (1 mg/kg) then 10% CO2, 20% O2, 70% N2 (between 0 and 0.1 hours) |
Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. |
arterial blood pressure trait |
not specified |
86.0 days
| 4 |
sampling once per minute |
|
135.0 |
mmHg |
1.5 |
3.0 |
intra-aortic thoracic radiotelemetry |
|
0.0 |
|
|
|
|
|
103200 |
2787 |
| SR/Jr |
mean arterial blood pressure |
controlled sodium chloride content diet (0.3 %) (for 42 days) then controlled sodium chloride content diet (8 %) (for 42 days) then atropine (1 mg/kg) then 10% CO2, 20% O2, 70% N2 (between 0 and 0.4 hours) |
Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. |
arterial blood pressure trait |
not specified |
86.0 days
| 5 |
sampling once per minute |
|
114.0 |
mmHg |
2.24 |
5.0 |
intra-aortic thoracic radiotelemetry |
|
0.0 |
|
|
|
|
|
103203 |
2787 |
| SS.BN-(D13Hmgc1048-D13Hmgc1045)/Mcwi |
mean arterial blood pressure |
controlled sodium chloride content diet (0.4 %) (between 23 and 32 days) |
Cowley AW Jr, et al., Physiol Genomics. 2016 Jan;48(1):62-72. doi: 10.1152/physiolgenomics.00097.2015. Epub 2015 Nov 3. |
arterial blood pressure trait |
male |
44.0 days-53.0 days |
11 |
|
serial mean |
103.0 |
mmHg |
2.0 |
6.63 |
intra-aortic thoracic radiotelemetry via carotid cannulation |
|
10800.0 |
|
|
carotid a. to thoracic aorta implant |
strain 26-O |
|
98474 |
2079 |
| SR/JrHsd |
body weight |
controlled sodium chloride content diet (0.4 %) (for 14 days) then sham surgical control condition then peanut oil (0.2 ml) (for 14 days) |
Zheng W, et al., Am J Physiol Heart Circ Physiol. 2008 Apr;294(4):H1508-13. doi: 10.1152/ajpheart.01322.2007. Epub 2008 Feb 1. |
body mass |
female |
days
| |
|
|
226.0 |
g |
4.7 |
|
body weighing method |
|
0.0 |
|
|
|
|
|
102183 |
2681 |
| SS/JrHsd |
body weight |
controlled sodium chloride content diet (4 %) (for 14 days) then bilateral ovariectomy then 17 beta-estradiol (10 ug/d) (for 14 days) |
Zheng W, et al., Am J Physiol Heart Circ Physiol. 2008 Apr;294(4):H1508-13. doi: 10.1152/ajpheart.01322.2007. Epub 2008 Feb 1. |
body mass |
female |
days
| |
|
|
228.0 |
g |
6.1 |
|
body weighing method |
|
0.0 |
|
|
|
|
|
102194 |
2681 |
| SS/JrHsd |
single kidney wet weight |
controlled sodium chloride content diet (0.4 %) (for 14 days) then sham surgical control condition then peanut oil (0.2 ml) (for 14 days) |
Zheng W, et al., Am J Physiol Heart Circ Physiol. 2008 Apr;294(4):H1508-13. doi: 10.1152/ajpheart.01322.2007. Epub 2008 Feb 1. |
kidney mass |
female |
days
| |
|
|
0.87 |
g |
0.02 |
|
post excision weight measurement |
|
0.0 |
|
|
|
|
|
102201 |
2681 |
| SR/JrHsd |
mean arterial blood pressure |
controlled sodium chloride content diet (0.4 %) (for 14 days) then sham surgical control condition then peanut oil (0.2 ml) (for 14 days) |
Zheng W, et al., Am J Physiol Heart Circ Physiol. 2008 Apr;294(4):H1508-13. doi: 10.1152/ajpheart.01322.2007. Epub 2008 Feb 1. |
arterial blood pressure trait |
female |
days
| |
|
|
122.0 |
mmHg |
4.0 |
|
vascular fluid filled catheter |
|
0.0 |
|
|
|
|
|
102207 |
2681 |
| SS/JrHsd |
mean arterial blood pressure |
controlled sodium chloride content diet (0.4 %) (for 14 days) then sham surgical control condition then peanut oil (0.2 ml) (for 14 days) |
Zheng W, et al., Am J Physiol Heart Circ Physiol. 2008 Apr;294(4):H1508-13. doi: 10.1152/ajpheart.01322.2007. Epub 2008 Feb 1. |
arterial blood pressure trait |
female |
days
| |
|
|
129.0 |
mmHg |
5.0 |
|
vascular fluid filled catheter |
|
0.0 |
|
|
|
|
|
102210 |
2681 |
| SS/JrHsd |
mean arterial blood pressure |
controlled sodium chloride content diet (0.4 %) (for 14 days) then bilateral ovariectomy then 17 beta-estradiol (10 ug/d) (for 14 days) |
Zheng W, et al., Am J Physiol Heart Circ Physiol. 2008 Apr;294(4):H1508-13. doi: 10.1152/ajpheart.01322.2007. Epub 2008 Feb 1. |
arterial blood pressure trait |
female |
days
| |
|
|
132.0 |
mmHg |
2.0 |
|
vascular fluid filled catheter |
|
0.0 |
|
|
|
|
|
102212 |
2681 |
| SR/JrHsd |
glomerular filtration rate to kidney weight ratio |
controlled sodium chloride content diet (0.4 %) (for 14 days) then sham surgical control condition then peanut oil (0.2 ml) (for 14 days) |
Zheng W, et al., Am J Physiol Heart Circ Physiol. 2008 Apr;294(4):H1508-13. doi: 10.1152/ajpheart.01322.2007. Epub 2008 Feb 1. |
glomerular filtration trait |
female |
days
| |
|
|
2.2 |
ml/min/g |
0.31 |
|
inulin analysis by liquid phase colorimetry |
|
0.0 |
|
|
|
|
|
102213 |
2681 |
| SR/JrHsd |
glomerular filtration rate to kidney weight ratio |
controlled sodium chloride content diet (0.4 %) (for 14 days) then bilateral ovariectomy then 17 beta-estradiol (10 ug/d) (for 14 days) |
Zheng W, et al., Am J Physiol Heart Circ Physiol. 2008 Apr;294(4):H1508-13. doi: 10.1152/ajpheart.01322.2007. Epub 2008 Feb 1. |
glomerular filtration trait |
female |
days
| |
|
|
1.97 |
ml/min/g |
0.25 |
|
inulin analysis by liquid phase colorimetry |
|
0.0 |
|
|
|
|
|
102215 |
2681 |
| SS/NEisSlc |
body weight |
controlled sodium chloride content diet (8 %) (for 21 days) then 0.9% sodium chloride solution (for 21 days) |
Yoshihara F, et al., Regul Pept. 2005 May 15;128(1):7-13. |
body mass |
male |
77.0 days
| 14 |
|
|
348.0 |
g |
4.01 |
15.0 |
body weighing method |
|
0.0 |
|
|
|
|
|
102454 |
2689 |
| SR/NEisSlc |
urine sodium excretion rate |
controlled sodium chloride content diet (8 %) (for 21 days) then 0.9% sodium chloride solution (for 21 days) |
Yoshihara F, et al., Regul Pept. 2005 May 15;128(1):7-13. |
urine sodium amount |
male |
77.0 days
| 19 |
|
|
2.2 |
mEq/d |
0.16 |
0.7 |
automated urine sodium analysis |
|
0.0 |
|
|
|
|
|
102468 |
2689 |
| SR/NEisSlc |
systolic blood pressure |
controlled sodium chloride content diet (0.3 %) (for 42 days) then controlled sodium chloride content diet (8 %) (for 84 days) |
Horinaka S, et al., Int J Cardiol. 2003 Sep;91(1):25-35. |
arterial blood pressure trait |
male |
126.0 days
| 10 |
undefined |
|
135.0 |
mmHg |
2.21 |
7.0 |
tail cuff plethysmography |
|
0.0 |
|
|
|
|
|
102493 |
2690 |
| SR/NEisSlc |
systolic blood pressure |
controlled sodium chloride content diet (0.3 %) (for 42 days) then controlled sodium chloride content diet (8 %) (for 35 days) |
Horinaka S, et al., Int J Cardiol. 2003 Sep;91(1):25-35. |
arterial blood pressure trait |
male |
77.0 days
| 10 |
undefined |
|
140.0 |
mmHg |
2.21 |
7.0 |
tail cuff plethysmography |
|
0.0 |
|
|
|
|
|
102492 |
2690 |
| SS/NEisSlc |
systolic blood pressure |
controlled sodium chloride content diet (0.3 %) (for 42 days) then controlled sodium chloride content diet (8 %) (for 35 days) |
Horinaka S, et al., Int J Cardiol. 2003 Sep;91(1):25-35. |
arterial blood pressure trait |
male |
77.0 days
| 10 |
undefined |
|
233.0 |
mmHg |
0.63 |
2.0 |
tail cuff plethysmography |
|
0.0 |
|
|
|
|
|
102494 |
2690 |
| SS/NEisSlc |
left ventricular end-diastolic blood pressure |
controlled sodium chloride content diet (0.3 %) (for 42 days) then controlled sodium chloride content diet (8 %) (for 84 days) then pentobarbital (20 mg/kg) |
Horinaka S, et al., Int J Cardiol. 2003 Sep;91(1):25-35. |
heart left ventricular blood pressure trait |
male |
126.0 days
| 10 |
|
|
2.8 |
mmHg |
0.85 |
2.7 |
volume pressure recording |
|
0.0 |
|
|
|
|
|
102509 |
2690 |
| SR/NEisSlc |
left ventricular end-diastolic blood pressure |
controlled sodium chloride content diet (0.3 %) (for 42 days) then controlled sodium chloride content diet (8 %) (for 35 days) then pentobarbital (20 mg/kg) |
Horinaka S, et al., Int J Cardiol. 2003 Sep;91(1):25-35. |
heart left ventricular blood pressure trait |
male |
77.0 days
| 10 |
|
|
2.2 |
mmHg |
0.6 |
1.9 |
volume pressure recording |
|
0.0 |
|
|
|
|
|
102508 |
2690 |
| SS/NEisSlc |
end-diastolic volume |
controlled sodium chloride content diet (0.3 %) (for 42 days) then controlled sodium chloride content diet (8 %) (for 35 days) then pentobarbital (20 mg/kg) |
Horinaka S, et al., Int J Cardiol. 2003 Sep;91(1):25-35. |
cardiac output trait |
male |
77.0 days
| 10 |
|
|
0.1 |
ml |
0.01 |
0.02 |
volume pressure recording |
|
0.0 |
|
|
|
|
|
102518 |
2690 |
| SS/NEisSlc |
heart left ventricle end-diastolic elastance |
controlled sodium chloride content diet (0.3 %) (for 42 days) then controlled sodium chloride content diet (8 %) (for 84 days) then pentobarbital (20 mg/kg) |
Horinaka S, et al., Int J Cardiol. 2003 Sep;91(1):25-35. |
heart left ventricular blood pressure trait |
male |
126.0 days
| 10 |
|
|
36.0 |
mmHg/ml |
3.48 |
11.0 |
volume pressure recording |
|
0.0 |
|
|
|
|
|
102529 |
2690 |
| SR/NEisSlc |
heart left ventricle diastolic volume-axis intercept |
controlled sodium chloride content diet (0.3 %) (for 42 days) then controlled sodium chloride content diet (8 %) (for 35 days) then pentobarbital (20 mg/kg) |
Horinaka S, et al., Int J Cardiol. 2003 Sep;91(1):25-35. |
cardiac output trait |
male |
77.0 days
| 10 |
|
|
0.08 |
ml |
0.02 |
0.07 |
volume pressure recording |
|
0.0 |
|
|
|
|
|
102532 |
2690 |
| SS/NEisSlc |
heart left ventricle end-diastolic elastance |
controlled sodium chloride content diet (0.3 %) (for 42 days) then controlled sodium chloride content diet (8 %) (for 84 days) then pentobarbital (20 mg/kg) |
Horinaka S, et al., Int J Cardiol. 2003 Sep;91(1):25-35. |
heart left ventricular blood pressure trait |
male |
126.0 days
| 10 |
|
|
47.0 |
mmHg/ml |
6.01 |
19.0 |
volume pressure recording |
|
0.0 |
|
|
|
|
|
102531 |
2690 |
| SS |
mean arterial blood pressure |
controlled sodium chloride content diet (8 %) (for 42 days) |
Wu F, et al., Int J Hypertens. 2016;2016:9146870. doi: 10.1155/2016/9146870. Epub 2016 Dec 19. |
arterial blood pressure trait |
male |
91.0 days
| 8 |
|
|
160.0 |
mmHg |
4.6 |
13.0 |
tail cuff plethysmography |
|
0.0 |
|
|
|
|
|
102268 |
2683 |
| LN/MavRrrcAek |
plasma glucose level |
standard rat chow (for 98 days) then controlled sodium chloride content diet (4 %) (for 14 days) |
Wang J, et al., Circ Cardiovasc Genet. 2015 Apr;8(2):316-26. doi: 10.1161/CIRCGENETICS.114.000520. Epub 2015 Jan 8. |
blood glucose amount |
male |
112.0 days
| 14 |
|
|
155.5 |
mg/dl |
7.7 |
28.81 |
plasma glucose analysis |
|
0.0 |
|
|
|
|
|
102624 |
3014 |
| LH/MavRrrcAek |
plasma triglyceride level |
standard rat chow (for 98 days) then controlled sodium chloride content diet (4 %) (for 28 days) |
Wang J, et al., Circ Cardiovasc Genet. 2015 Apr;8(2):316-26. doi: 10.1161/CIRCGENETICS.114.000520. Epub 2015 Jan 8. |
blood triglyceride amount |
male |
126.0 days
| 9 |
|
|
0.91 |
mmol/l |
0.07 |
0.21 |
plasma triglyceride analysis |
|
0.0 |
|
|
|
|
|
102629 |
3014 |
| SS.BN-(D13Rat25-RN34_13048990782)/Mcwi |
mean arterial blood pressure |
controlled sodium chloride content diet (0.4 %) (for 70 days) then controlled sodium chloride content diet (8 %) (for 21 days) |
Flister MJ, et al., Hypertension. 2013 Apr;61(4):850-6. doi: 10.1161/HYPERTENSIONAHA.111.01008. Epub 2013 Mar 4. |
arterial blood pressure trait |
male |
91.0 days
| 21 |
|
serial mean |
169.0 |
mmHg |
6.0 |
27.5 |
intra-aortic abdominal radiotelemetry via femoral cannulation |
|
10800.0 |
|
|
|
strain 9C |
|
98723 |
2142 |
| SS-Plod1em1Mcwi-/- |
mean arterial blood pressure |
controlled sodium chloride content diet (0.4 %) (between 56 and 63 days) then controlled sodium chloride content diet (4 %) (for 10 days) |
Flister MJ, et al., Genome Res. 2013 Dec;23(12):1996-2002. doi: 10.1101/gr.160283.113. Epub 2013 Sep 4. |
arterial blood pressure trait |
male |
58.0 days-67.0 days |
|
|
serial mean |
143.0 |
mmHg |
3.0 |
|
intra-aortic abdominal radiotelemetry |
|
32400.0 |
|
|
|
|
|
98397 |
2059 |
| SS.BN-(D13Hmgc115-D13Got22)/Mcwi |
mean arterial blood pressure |
controlled sodium chloride content diet (0.4 %) (for 68 days) then controlled sodium chloride content diet (8 %) (for 21 days) |
Moreno C, et al., Am J Physiol Heart Circ Physiol. 2011 Apr;300(4):H1530-5. doi: 10.1152/ajpheart.01026.2010. Epub 2011 Jan 21. |
arterial blood pressure trait |
male |
89.0 days
| 12 |
|
serial mean |
156.0 |
mmHg |
4.0 |
13.86 |
intra-aortic abdominal radiotelemetry via femoral cannulation |
|
10800.0 |
|
|
|
strain 5-2 |
|
98675 |
2138 |
| SR/Jr |
heart weight to body weight ratio |
controlled sodium chloride content diet (8 %) (for 35 days) |
Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. |
heart mass |
male |
63.0 days
| 13 |
|
|
2.56 |
g/kg |
0.04 |
0.14 |
post excision weight measurement |
|
0.0 |
|
|
|
|
|
103239 |
2802 |
| SR/Jr |
systolic blood pressure |
controlled sodium chloride content diet (8 %) (for 35 days) |
Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. |
arterial blood pressure trait |
male |
63.0 days
| 13 |
|
|
138.0 |
mmHg |
3.0 |
10.82 |
vascular transducer tipped catheter |
|
0.0 |
|
|
|
|
|
103247 |
2802 |
| SS/Jr |
systolic blood pressure |
controlled sodium chloride content diet (8 %) (for 35 days) |
Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. |
arterial blood pressure trait |
male |
63.0 days
| 10 |
|
|
189.0 |
mmHg |
6.0 |
23.24 |
vascular transducer tipped catheter |
|
0.0 |
|
|
|
|
|
103249 |
2802 |
| SR/Jr |
plasma total cholesterol level |
controlled sodium chloride content diet (0.3 %) (for 35 days) |
Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. |
blood cholesterol amount |
male |
63.0 days
| 16 |
|
|
69.88 |
mg/dl |
6.95 |
27.8 |
plasma total cholesterol measurement test |
|
0.0 |
|
|
|
|
|
103262 |
2802 |
| SR/Jr |
hematocrit |
controlled sodium chloride content diet (8 %) (for 35 days) |
Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. |
erythrocyte quantity |
male |
63.0 days
| 13 |
|
|
43.5 |
% |
0.5 |
1.8 |
hematocrit analysis |
|
0.0 |
|
|
|
|
|
103267 |
2802 |
| SS |
urine sodium level |
controlled sodium chloride content diet (8 %) (for 28 days) |
Wu F, et al., Int J Hypertens. 2016;2016:9146870. doi: 10.1155/2016/9146870. Epub 2016 Dec 19. |
urine sodium amount |
male |
77.0 days
| 8 |
|
|
1.9 |
mmol/l |
0.07 |
0.2 |
urine sodium analysis |
|
0.0 |
|
|
|
|
|
102282 |
2683 |
| SR/Hsd |
urine sodium level |
controlled sodium chloride content diet (8 %) (for 42 days) |
Wu F, et al., Int J Hypertens. 2016;2016:9146870. doi: 10.1155/2016/9146870. Epub 2016 Dec 19. |
urine sodium amount |
male |
91.0 days
| 8 |
|
|
3.1 |
mmol/l |
0.07 |
0.2 |
urine sodium analysis |
|
0.0 |
|
|
|
|
|
102285 |
2683 |
| SR/Hsd |
creatinine clearance |
controlled sodium chloride content diet (8 %) (for 42 days) |
Wu F, et al., Int J Hypertens. 2016;2016:9146870. doi: 10.1155/2016/9146870. Epub 2016 Dec 19. |
glomerular filtration trait |
male |
91.0 days
| 8 |
|
|
6.1 |
ml/min |
0.28 |
0.8 |
urine creatinine analysis |
|
0.0 |
|
|
|
|
|
102289 |
2683 |
| SS |
creatinine clearance |
controlled sodium chloride content diet (8 %) (for 42 days) |
Wu F, et al., Int J Hypertens. 2016;2016:9146870. doi: 10.1155/2016/9146870. Epub 2016 Dec 19. |
glomerular filtration trait |
male |
91.0 days
| 8 |
|
|
2.8 |
ml/min |
0.07 |
0.2 |
urine creatinine analysis |
|
0.0 |
|
|
|
|
|
102288 |
2683 |
| SS/NEisSlc |
heart left ventricle plus septum weight to body weight ratio |
controlled sodium chloride content diet (8 %) (for 7 days) |
Yoshihara F, et al., Regul Pept. 2005 May 15;128(1):7-13. |
heart left ventricle mass |
male |
63.0 days
| 8 |
|
|
2.19 |
mg/g |
0.02 |
0.07 |
post excision weight measurement |
|
0.0 |
|
|
|
heart left ventricle plus septum weight to body weight ratio (CMO:0003869) |
|
102418 |
2689 |
| SR/NEisSlc |
heart left ventricle plus septum weight to body weight ratio |
controlled sodium chloride content diet (8 %) (for 21 days) |
Yoshihara F, et al., Regul Pept. 2005 May 15;128(1):7-13. |
heart left ventricle mass |
male |
77.0 days
| 7 |
|
|
1.97 |
mg/g |
0.04 |
0.11 |
post excision weight measurement |
|
0.0 |
|
|
|
heart left ventricle plus septum weight to body weight ratio (CMO:0003869) |
|
102421 |
2689 |
| SR/NEisSlc |
single kidney wet weight to body weight ratio |
controlled sodium chloride content diet (8 %) (for 7 days) |
Yoshihara F, et al., Regul Pept. 2005 May 15;128(1):7-13. |
kidney mass |
male |
63.0 days
| 7 |
|
|
3.69 |
g/kg |
0.1 |
0.26 |
post excision weight measurement |
|
0.0 |
|
|
|
|
|
102423 |
2689 |
| SR/NEisSlc |
systolic blood pressure |
controlled sodium chloride content diet (8 %) (for 14 days) |
Yoshihara F, et al., Regul Pept. 2005 May 15;128(1):7-13. |
arterial blood pressure trait |
male |
70.0 days
| 8 |
mean of 3 samples of undefined duration |
serial mean |
124.0 |
mmHg |
3.18 |
9.0 |
tail cuff plethysmography |
|
0.0 |
|
|
|
|
|
102431 |
2689 |
| SS/NEisSlc |
urine sodium excretion rate |
controlled sodium chloride content diet (8 %) (for 7 days) |
Yoshihara F, et al., Regul Pept. 2005 May 15;128(1):7-13. |
urine sodium amount |
male |
63.0 days
| 8 |
|
|
2.4 |
mEq/d |
0.25 |
0.7 |
automated urine sodium analysis |
|
0.0 |
|
|
|
|
|
102436 |
2689 |
| SS/NEisSlc |
urine sodium excretion rate |
controlled sodium chloride content diet (8 %) (for 21 days) |
Yoshihara F, et al., Regul Pept. 2005 May 15;128(1):7-13. |
urine sodium amount |
male |
77.0 days
| 8 |
|
|
1.2 |
mEq/d |
0.11 |
0.3 |
automated urine sodium analysis |
|
0.0 |
|
|
|
|
|
102440 |
2689 |
| SR/NEisSlc |
kidney cortical adrenomedullin level |
controlled sodium chloride content diet (8 %) (for 14 days) |
Yoshihara F, et al., Regul Pept. 2005 May 15;128(1):7-13. |
kidney adrenomedullin amount |
male |
70.0 days
| 8 |
|
|
0.56 |
fmol/mg |
0.02 |
0.06 |
radioimmunoassay |
|
0.0 |
|
|
|
|
|
102443 |
2689 |
| SR/NEisSlc |
kidney cortical adrenomedullin level |
controlled sodium chloride content diet (8 %) (for 21 days) |
Yoshihara F, et al., Regul Pept. 2005 May 15;128(1):7-13. |
kidney adrenomedullin amount |
male |
77.0 days
| 7 |
|
|
0.55 |
fmol/mg |
0.02 |
0.06 |
radioimmunoassay |
|
0.0 |
|
|
|
|
|
102445 |
2689 |
| SS/NEisSlc |
kidney cortical adrenomedullin level |
controlled sodium chloride content diet (8 %) (for 14 days) |
Yoshihara F, et al., Regul Pept. 2005 May 15;128(1):7-13. |
kidney adrenomedullin amount |
male |
70.0 days
| 7 |
|
|
0.61 |
fmol/mg |
0.03 |
0.09 |
radioimmunoassay |
|
0.0 |
|
|
|
|
|
102444 |
2689 |
| SR/NEisSlc |
kidney medullary adrenomedullin level |
controlled sodium chloride content diet (8 %) (for 14 days) |
Yoshihara F, et al., Regul Pept. 2005 May 15;128(1):7-13. |
kidney adrenomedullin amount |
male |
70.0 days
| 8 |
|
|
0.34 |
fmol/mg |
0.01 |
0.04 |
radioimmunoassay |
|
0.0 |
|
|
|
|
|
102449 |
2689 |
| SR/NEisSlc |
urine total protein excretion rate to body weight ratio |
controlled sodium chloride content diet (8 %) (for 7 days) then 0.9% sodium chloride solution (for 7 days) |
Yoshihara F, et al., Regul Pept. 2005 May 15;128(1):7-13. |
total urine protein amount |
male |
63.0 days
| 19 |
|
|
3.4 |
mg/d/100 g |
0.25 |
1.1 |
urine protein analysis |
|
0.0 |
|
|
|
|
|
102471 |
2689 |
| SS/NEisSlc |
urine total protein excretion rate to body weight ratio |
controlled sodium chloride content diet (8 %) (for 14 days) then adrenomedulin (400 ng/hr) (for 14 days) |
Yoshihara F, et al., Regul Pept. 2005 May 15;128(1):7-13. |
total urine protein amount |
male |
70.0 days
| 14 |
|
|
4.5 |
mg/d/100 g |
0.32 |
1.2 |
urine protein analysis |
|
0.0 |
|
|
|
|
|
102476 |
2689 |
| SS-Nppbem2Mcwi-/- |
single kidney wet weight |
controlled sodium chloride content diet (0.4 %) (between 56 and 63 days) then controlled sodium chloride content diet (4 %) (for 12 days) |
Flister MJ, et al., Genome Res. 2013 Dec;23(12):1996-2002. doi: 10.1101/gr.160283.113. Epub 2013 Sep 4. |
kidney mass |
male |
60.0 days-69.0 days |
|
|
|
1.45 |
g |
0.02 |
|
digital scale post excision weight measurement |
|
0.0 |
|
|
|
|
|
98452 |
2059 |
| SS-Agtrapem4Mcwi-/- |
single kidney wet weight |
controlled sodium chloride content diet (0.4 %) (between 56 and 63 days) then controlled sodium chloride content diet (4 %) (for 12 days) |
Flister MJ, et al., Genome Res. 2013 Dec;23(12):1996-2002. doi: 10.1101/gr.160283.113. Epub 2013 Sep 4. |
kidney mass |
male |
60.0 days-69.0 days |
|
|
|
1.37 |
g |
0.05 |
|
digital scale post excision weight measurement |
|
0.0 |
|
|
|
|
|
98456 |
2059 |
| SS/Hsd |
urine total protein excretion rate |
controlled sodium chloride content diet (0.4 %) (between 56 and 63 days) then controlled sodium chloride content diet (4 %) (for 12 days) |
Flister MJ, et al., Genome Res. 2013 Dec;23(12):1996-2002. doi: 10.1101/gr.160283.113. Epub 2013 Sep 4. |
total urine protein amount |
male |
60.0 days-69.0 days |
|
|
|
91.0 |
mg/d |
5.0 |
|
urine total protein analysis |
|
0.0 |
|
|
|
|
|
98436 |
2059 |
| SR/Jr |
body weight |
controlled sodium chloride content diet (8 %) (for 35 days) |
Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. |
body mass |
male |
63.0 days
| 13 |
|
|
225.0 |
g |
8.0 |
28.84 |
body weighing method |
|
0.0 |
|
|
|
|
|
103235 |
2802 |
| SR/Jr |
body weight |
controlled sodium chloride content diet (0.3 %) (for 35 days) |
Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. |
body mass |
male |
63.0 days
| 16 |
|
|
218.0 |
g |
9.0 |
36.0 |
body weighing method |
|
0.0 |
|
|
|
|
|
103234 |
2802 |
| SD-Nfe2l2em1Mcwi-/- |
mean arterial blood pressure |
controlled sodium chloride content diet (0.4 %) (between 35 and 49 days) |
Priestley JR, et al., Am J Physiol Heart Circ Physiol. 2016 Feb 15;310(4):H478-87. doi: 10.1152/ajpheart.00586.2015. Epub 2015 Dec 4. |
arterial blood pressure trait |
male |
56.0 days-70.0 days |
4 |
|
|
95.0 |
mmHg |
2.6 |
5.2 |
vascular fluid filled catheter |
|
0.0 |
|
|
|
|
|
100738 |
2520 |
| SD-Nfe2l2em1Mcwi-/- |
body weight |
controlled sodium chloride content diet (0.4 %) (between 70 and 84 days) then controlled sodium chloride content diet (4 %) (for 3 days) then angiotensin II (100 ng/kg/min) (for 3 days) |
Priestley JR, et al., Am J Physiol Heart Circ Physiol. 2016 Feb 15;310(4):H478-87. doi: 10.1152/ajpheart.00586.2015. Epub 2015 Dec 4. |
body mass |
male |
62.0 days-76.0 days |
6 |
|
|
307.0 |
g |
11.5 |
28.17 |
body weighing method |
|
0.0 |
|
|
|
|
|
100736 |
2520 |
| SS-Plekha7em4Mcwi-/- |
nephron count |
controlled sodium chloride content diet (8 %) (for 28 days) |
Endres BT, et al., Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):12817-22. doi: 10.1073/pnas.1410745111. Epub 2014 Aug 18. |
nephron morphology trait |
male |
91.0 days
| 10 |
|
|
34330.0 |
null |
480.0 |
1517.89 |
ex vivo light microscopy with histochemistry and digital image analysis |
|
0.0 |
|
|
|
nephron count |
|
105750 |
3022 |
| SS-Shc1em4Mcwi |
renal afferent arteriole diameter |
controlled sodium chloride content diet (1 %) (between 70 and 91 days) then controlled ex vivo artery perfusion pressure (60 mmHg) (for 0.1 hours) |
Miller B, et al., J Clin Invest. 2016 Jul 1;126(7):2533-46. doi: 10.1172/JCI75079. Epub 2016 Jun 6. |
kidney arteriole morphology trait |
not specified |
91.0 days-133.0 days |
5 |
|
|
21.7 |
um |
0.8 |
1.79 |
ex vivo videomicroscopy |
renal afferent arteriole |
120.0 |
|
|
ex vivo videomicroscopy (MMO:0000319) |
renal afferent arteriole diameter (CMO:0003725) |
renal arteriole morphology trait |
106497 |
3030 |
| SS-Shc1em5Mcwi |
renal afferent arteriole diameter |
controlled sodium chloride content diet (1 %) (between 70 and 91 days) then controlled ex vivo artery perfusion pressure (60 mmHg) (for 0.1 hours) |
Miller B, et al., J Clin Invest. 2016 Jul 1;126(7):2533-46. doi: 10.1172/JCI75079. Epub 2016 Jun 6. |
kidney arteriole morphology trait |
not specified |
91.0 days-133.0 days |
7 |
|
|
24.1 |
um |
1.7 |
4.5 |
ex vivo videomicroscopy |
renal afferent arteriole |
120.0 |
|
|
ex vivo videomicroscopy (MMO:0000319) |
renal afferent arteriole diameter (CMO:0003725) |
renal arteriole morphology trait |
106498 |
3030 |
| SS-Shc1em1Mcwi |
renal afferent arteriole diameter |
controlled sodium chloride content diet (1 %) (between 70 and 91 days) then controlled ex vivo artery perfusion pressure (60 mmHg) (for 0.1 hours) |
Miller B, et al., J Clin Invest. 2016 Jul 1;126(7):2533-46. doi: 10.1172/JCI75079. Epub 2016 Jun 6. |
kidney arteriole morphology trait |
not specified |
91.0 days-133.0 days |
10 |
|
|
21.4 |
um |
1.2 |
3.79 |
ex vivo videomicroscopy |
renal afferent arteriole |
120.0 |
|
|
ex vivo videomicroscopy (MMO:0000319) |
renal afferent arteriole diameter (CMO:0003725) |
renal arteriole morphology trait |
106501 |
3030 |
| SS/JrHsdMcwi |
spleen weight |
controlled sodium chloride content diet (0.4 %) (for 42 days) |
Rudemiller NP, et al., Hypertension. 2015 May;65(5):1111-7. doi: 10.1161/HYPERTENSIONAHA.114.04736. Epub 2015 Mar 16. |
spleen mass |
not specified |
63.0 days
| 4 |
|
|
1.5 |
g |
0.1 |
0.2 |
post excision weight measurement |
|
0.0 |
|
|
|
n=4-7 |
|
106508 |
3031 |
| SS-Sh2b3em1Mcwi-/- |
blood mononuclear cell count |
controlled sodium chloride content diet (0.4 %) (for 21 days) |
Rudemiller NP, et al., Hypertension. 2015 May;65(5):1111-7. doi: 10.1161/HYPERTENSIONAHA.114.04736. Epub 2015 Mar 16. |
leukocyte quantity |
not specified |
84.0 days
| 4 |
|
|
14.7 |
x 10E6 cells/ml |
0.6 |
1.2 |
flow cytometry method |
|
0.0 |
|
|
|
n=4-7 |
|
106511 |
3031 |
| SS-Sh2b3em1Mcwi-/- |
blood T lymphocyte count |
controlled sodium chloride content diet (0.4 %) (for 42 days) |
Rudemiller NP, et al., Hypertension. 2015 May;65(5):1111-7. doi: 10.1161/HYPERTENSIONAHA.114.04736. Epub 2015 Mar 16. |
T cell quantity |
not specified |
63.0 days
| 4 |
|
|
7.0 |
x 10E6 cells/ml |
0.4 |
0.8 |
flow cytometry method |
|
0.0 |
|
|
|
n=4-7 |
|
106513 |
3031 |
| SS/JrHsdMcwi |
blood regulatory T cell count to total T cell count ratio |
controlled sodium chloride content diet (0.4 %) (for 42 days) |
Rudemiller NP, et al., Hypertension. 2015 May;65(5):1111-7. doi: 10.1161/HYPERTENSIONAHA.114.04736. Epub 2015 Mar 16. |
T cell quantity |
not specified |
63.0 days
| 4 |
|
|
4.0 |
% |
0.1 |
0.2 |
flow cytometry method |
|
0.0 |
|
|
|
n=4-7 -tregs spleen % |
|
106518 |
3031 |
| SS/JrHsdMcwi |
mean arterial blood pressure |
controlled sodium chloride content diet (0.4 %) (for 70 days) then controlled sodium chloride content diet (4 %) (for 21 days) |
Rudemiller NP, et al., Hypertension. 2015 May;65(5):1111-7. doi: 10.1161/HYPERTENSIONAHA.114.04736. Epub 2015 Mar 16. |
arterial blood pressure trait |
not specified |
91.0 days
| 6 |
15sec/min for 3 hrs/day |
|
175.5 |
mmHg |
7.9 |
19.35 |
vascular fluid filled catheter |
|
0.0 |
|
|
|
n=6-8 |
|
106522 |
3031 |
| SS/JrHsdMcwi |
urine albumin excretion rate |
controlled sodium chloride content diet (0.4 %) (for 42 days) |
Rudemiller NP, et al., Hypertension. 2015 May;65(5):1111-7. doi: 10.1161/HYPERTENSIONAHA.114.04736. Epub 2015 Mar 16. |
urine albumin amount |
not specified |
63.0 days
| 6 |
|
|
20.0 |
mg/d |
2.1 |
5.14 |
urine albumin analysis |
|
0.0 |
|
|
|
n=6-8 |
|
106524 |
3031 |
| SS-Sh2b3em1Mcwi-/- |
urine albumin excretion rate |
controlled sodium chloride content diet (0.4 %) (for 42 days) then controlled sodium chloride content diet (4 %) (for 21 days) |
Rudemiller NP, et al., Hypertension. 2015 May;65(5):1111-7. doi: 10.1161/HYPERTENSIONAHA.114.04736. Epub 2015 Mar 16. |
urine albumin amount |
not specified |
84.0 days
| 6 |
|
|
30.3 |
mg/d |
7.0 |
17.15 |
urine albumin analysis |
|
0.0 |
|
|
|
n=6-8 |
|
106529 |
3031 |
| SBH/Ygl |
body weight |
controlled sodium chloride content diet (8 %) (for 42 days) then streptozotocin (60 mg/kg) then insulin (10 ul) (for 42 days) |
Landau D, et al., J Endocrinol. 2008 Apr;197(1):75-83. doi: 10.1677/JOE-08-0040. |
body mass |
male |
98.0 days
| 7 |
|
|
216.0 |
g |
13.0 |
34.39 |
body weighing method |
|
0.0 |
|
|
|
|
|
106703 |
3038 |
| SBH/Ygl |
food intake weight to body weight ratio |
controlled sodium chloride content diet (0.65 %) (for 84 days) then streptozotocin (60 mg/kg) then insulin (10 ul) (for 28 days) |
Landau D, et al., J Endocrinol. 2008 Apr;197(1):75-83. doi: 10.1677/JOE-08-0040. |
eating behavior trait |
male |
84.0 days
| 7 |
|
|
18.04 |
g/d/100g |
0.82 |
2.17 |
food intake measuring method |
|
0.0 |
|
|
|
|
|
106706 |
3038 |
| SBH/Ygl |
heart weight |
controlled sodium chloride content diet (0.65 %) (for 98 days) then streptozotocin (60 mg/kg) then insulin (10 ul) (for 42 days) |
Landau D, et al., J Endocrinol. 2008 Apr;197(1):75-83. doi: 10.1677/JOE-08-0040. |
heart mass |
male |
98.0 days
| 7 |
|
|
1.07 |
g |
0.07 |
0.18 |
post excision weight measurement |
|
0.0 |
|
|
|
|
|
106710 |
3038 |
| SBH/Ygl |
heart left ventricle fractional shortening |
controlled sodium chloride content diet (0.65 %) (for 98 days) then streptozotocin (60 mg/kg) then insulin (10 ul) (for 42 days) |
Landau D, et al., J Endocrinol. 2008 Apr;197(1):75-83. doi: 10.1677/JOE-08-0040. |
heart left ventricle end-diastolic diameter |
male |
98.0 days
| 7 |
|
|
61.0 |
% |
4.0 |
10.58 |
transthoracic echocardiography |
|
0.0 |
|
|
|
|
|
106714 |
3038 |
| SS/HsdMcwiCrl |
heart rate |
controlled sodium chloride content diet (8 %) (between 28 and 42 days) |
Gabor A and Leenen FH, Brain Res. 2012 Apr 4;1447:28-37. doi: 10.1016/j.brainres.2012.01.060. Epub 2012 Feb 1. |
heart pumping trait |
male |
77.0 days-98.0 days |
5 |
|
|
454.0 |
beats/min |
7.0 |
15.65 |
vascular fluid filled catheter |
femoral artery |
600.0 |
|
|
|
|
|
106775 |
2685 |
| SS/HsdMcwiCrl |
mean arterial blood pressure |
controlled sodium chloride content diet (8 %) (between 28 and 42 days) |
Gabor A and Leenen FH, Brain Res. 2012 Apr 4;1447:28-37. doi: 10.1016/j.brainres.2012.01.060. Epub 2012 Feb 1. |
arterial blood pressure trait |
male |
77.0 days-98.0 days |
5 |
MAP=.33(SP-DP) + DP |
|
149.0 |
mmHg |
4.0 |
8.94 |
vascular fluid filled catheter |
femoral artery |
600.0 |
|
|
|
|
|
106776 |
2685 |
| SS-Chr 13BN/McwiCrl |
heart rate |
controlled sodium chloride content diet (8 %) (between 28 and 42 days) then candesartan (0.5 ug/min) (for 0.2 hours) then kynurenate (0.14 ug/min) (for 0.2 hours) |
Gabor A and Leenen FH, Brain Res. 2012 Apr 4;1447:28-37. doi: 10.1016/j.brainres.2012.01.060. Epub 2012 Feb 1. |
heart pumping trait |
male |
77.0 days-98.0 days |
5 |
|
|
425.0 |
beats/min |
12.0 |
26.83 |
vascular fluid filled catheter |
femoral artery |
600.0 |
|
|
|
|
|
106781 |
2685 |
| SS/HsdMcwiCrl |
heart rate |
controlled sodium chloride content diet (8 %) (between 28 and 42 days) then candesartan (0.5 ug/min) (for 0.2 hours) then kynurenate (0.14 ug/min) (for 0.2 hours) |
Gabor A and Leenen FH, Brain Res. 2012 Apr 4;1447:28-37. doi: 10.1016/j.brainres.2012.01.060. Epub 2012 Feb 1. |
heart pumping trait |
male |
77.0 days-98.0 days |
5 |
|
|
466.0 |
beats/min |
10.0 |
22.36 |
vascular fluid filled catheter |
femoral artery |
600.0 |
|
|
|
|
|
106783 |
2685 |
| SS/HsdMcwiCrl |
heart rate |
controlled sodium chloride content diet (8 %) (between 28 and 42 days) then kynurenate (0.14 ug/min) (for 0.2 hours) then candesartan (0.5 ug/min) (for 0.2 hours) |
Gabor A and Leenen FH, Brain Res. 2012 Apr 4;1447:28-37. doi: 10.1016/j.brainres.2012.01.060. Epub 2012 Feb 1. |
heart pumping trait |
male |
77.0 days-98.0 days |
5 |
|
|
410.0 |
beats/min |
15.0 |
33.54 |
vascular fluid filled catheter |
femoral artery |
600.0 |
|
|
|
|
|
106784 |
2685 |
| SS/HsdMcwiCrl |
mean arterial blood pressure |
controlled sodium chloride content diet (0.1 %) (between 28 and 42 days) |
Gabor A and Leenen FH, Brain Res. 2012 Apr 4;1447:28-37. doi: 10.1016/j.brainres.2012.01.060. Epub 2012 Feb 1. |
arterial blood pressure trait |
male |
77.0 days-98.0 days |
4 |
MAP=.33(SP-DP) + DP |
|
109.0 |
mmHg |
2.0 |
4.0 |
vascular fluid filled catheter |
femoral artery |
600.0 |
|
|
|
|
|
106767 |
2685 |
| SS/HsdMcwiCrl |
heart rate |
controlled sodium chloride content diet (0.1 %) (between 28 and 42 days) |
Gabor A and Leenen FH, Brain Res. 2012 Apr 4;1447:28-37. doi: 10.1016/j.brainres.2012.01.060. Epub 2012 Feb 1. |
heart pumping trait |
male |
77.0 days-98.0 days |
4 |
|
|
442.0 |
beats/min |
4.0 |
8.0 |
vascular fluid filled catheter |
femoral artery |
600.0 |
|
|
|
|
|
106770 |
2685 |
| SS/HsdMcwiCrl |
mean arterial blood pressure |
controlled sodium chloride content diet (0.1 %) (between 28 and 42 days) then 2% dimethyl sulfoxide in artificial cerebrospinal fluid (300 nl/min) (for 0.2 hours) then kynurenate (0.14 ug/min) (for 0.2 hours) |
Gabor A and Leenen FH, Brain Res. 2012 Apr 4;1447:28-37. doi: 10.1016/j.brainres.2012.01.060. Epub 2012 Feb 1. |
arterial blood pressure trait |
male |
77.0 days-98.0 days |
5 |
MAP=.33(SP-DP) + DP |
|
110.0 |
mmHg |
2.0 |
4.47 |
vascular fluid filled catheter |
femoral artery |
600.0 |
|
|
|
|
|
106764 |
2685 |
| SBH/Ygl |
blood glucose level |
controlled sodium chloride content diet (8 %) (for 42 days) |
Landau D, et al., J Endocrinol. 2008 Apr;197(1):75-83. doi: 10.1677/JOE-08-0040. |
blood glucose amount |
male |
98.0 days
| 7 |
|
|
109.8 |
mg/dl |
3.6 |
9.52 |
blood glucose test strip read by electrochemical glucometer |
|
0.0 |
|
|
|
|
|
106693 |
3038 |
| LH/MavRrrcAek |
maximum slope of body weight growth curve |
standard rat chow (for 98 days) then controlled sodium chloride content diet (4 %) (for 21 days) |
Wang J, et al., Circ Cardiovasc Genet. 2015 Apr;8(2):316-26. doi: 10.1161/CIRCGENETICS.114.000520. Epub 2015 Jan 8. |
body mass |
male |
21.0 days-126.0 days |
|
y=mx + c |
|
45.1 |
g/week |
0.74 |
|
body weighing method |
|
0.0 |
|
|
|
maximum slope of body weight growth curve (CMO:0003452) |
|
107402 |
3014 |
| LN/MavRrrcAek |
maximum slope of body weight growth curve |
standard rat chow (for 98 days) then controlled sodium chloride content diet (4 %) (for 21 days) |
Wang J, et al., Circ Cardiovasc Genet. 2015 Apr;8(2):316-26. doi: 10.1161/CIRCGENETICS.114.000520. Epub 2015 Jan 8. |
body mass |
male |
21.0 days-126.0 days |
|
y=mx+c |
|
35.2 |
g/week |
0.52 |
|
body weighing method |
|
0.0 |
|
|
|
maximum slope of body weight growth curve (CMO:0003452) |
|
107403 |
3014 |
| MHS/Gib |
systolic blood pressure |
controlled sodium chloride content diet (2.5 g/kg) |
Ferrandi M, etal., Am J Physiol. 1999 Oct;277(4):H1338-49. doi: 10.1152/ajpheart.1999.277.4.H1338. |
arterial blood pressure trait |
male |
91.0 days
| |
|
|
167.0 |
mmHg |
2.0 |
|
tail cuff plethysmography |
|
0.0 |
|
|
|
|
|
110652 |
3135 |
| SHRSP/A3NCrl |
urine sodium excretion rate |
controlled sodium chloride content diet (1 %) (for 56 days) and controlled fat content diet (24.5 %) (for 56 days) |
Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. |
urine sodium amount |
male |
84.0 days-91.0 days |
9 |
|
|
2.4 |
mEq/d |
0.4 |
1.2 |
urine sodium analysis |
|
86400.0 |
|
|
baseline |
baseline high salt high fat diet group |
|
107063 |
3073 |
| SS/Jr |
bumetanide-sensitive red blood cell Na+ export rate |
controlled sodium chloride content diet (8 %) (for 35 days) |
Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. |
erythrocyte ion transport trait |
male |
63.0 days
| 10 |
|
|
614.0 |
umol/l/h |
160.0 |
505.96 |
Na-K-Cl cotransport activity assay |
|
0.0 |
|
|
|
|
|
111040 |
2802 |
| SR/Jr |
ouabain- and bumetanide-resistant red blood cell Na+ import rate |
controlled sodium chloride content diet (8 %) (for 35 days) |
Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. |
erythrocyte ion transport trait |
male |
63.0 days
| 13 |
|
|
3407.0 |
umol/l/h |
114.0 |
411.03 |
Na+ passive permeability assay |
|
0.0 |
|
|
|
|
|
111042 |
2802 |
| SS/Jr |
ouabain- and bumetanide-resistant red blood cell Na+ import rate |
controlled sodium chloride content diet (8 %) (for 35 days) |
Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. |
erythrocyte ion transport trait |
male |
63.0 days
| 10 |
|
|
5466.0 |
umol/l/h |
525.0 |
1660.2 |
Na+ passive permeability assay |
|
0.0 |
|
|
|
|
|
111044 |
2802 |
| SS/Jr |
ouabain-sensitive red blood cell K+ import rate |
controlled sodium chloride content diet (0.3 %) (for 35 days) |
Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. |
erythrocyte ion transport trait |
male |
63.0 days
| 15 |
|
|
4472.0 |
umol/l/h |
127.0 |
491.87 |
Na+/K+ ATPase activity assay |
|
0.0 |
|
|
|
|
|
111047 |
2802 |
| LEW/Mol |
body weight |
controlled sodium chloride content diet (8 %) (for 56 days) |
Kreutz R, etal., J Hypertens. 2000 Jun;18(6):777-82. doi: 10.1097/00004872-200018060-00017. |
body mass |
female |
104.0 days
| 8 |
|
|
195.0 |
g |
1.7 |
4.81 |
body weighing method |
|
0.0 |
|
|
|
|
|
108998 |
3134 |
| MWF/Fub |
body weight |
controlled sodium chloride content diet (8 %) (for 56 days) |
Kreutz R, etal., J Hypertens. 2000 Jun;18(6):777-82. doi: 10.1097/00004872-200018060-00017. |
body mass |
female |
104.0 days
| 8 |
|
|
188.0 |
g |
1.6 |
4.53 |
body weighing method |
|
0.0 |
|
|
|
|
|
109002 |
3134 |
| LEW/Mol |
kidney wet weight to body weight ratio |
controlled sodium chloride content diet (8 %) (for 56 days) |
Kreutz R, etal., J Hypertens. 2000 Jun;18(6):777-82. doi: 10.1097/00004872-200018060-00017. |
kidney mass |
female |
104.0 days
| 8 |
|
|
4.48 |
mg/g |
0.0 |
0.0 |
post excision weight measurement |
kidney |
0.0 |
|
|
|
|
|
109014 |
3134 |
| LEW/Mol |
kidney wet weight to body weight ratio |
controlled sodium chloride content diet (8 %) (for 56 days) |
Kreutz R, etal., J Hypertens. 2000 Jun;18(6):777-82. doi: 10.1097/00004872-200018060-00017. |
kidney mass |
male |
104.0 days
| 8 |
|
|
4.33 |
mg/g |
0.09 |
0.25 |
post excision weight measurement |
kidney |
0.0 |
|
|
|
|
|
109015 |
3134 |
