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| Strain |
Phenotype |
Conditions |
Study |
Experiment Name |
Sex |
Age |
# of Animals |
Value |
Units |
SEM |
SD |
Method |
Method Duration |
Post Insult Time Value |
Method Notes |
Clinical Measurement Notes |
Record ID |
Study ID |
| SD |
volume of distribution of nifedipine in the blood |
nifedipine (200 ug/kg) |
Lu J, et al., Sci Rep. 2017 Feb 20;7:42922. doi: 10.1038/srep42922. |
blood xenobiotic amount |
both |
56.0 days
| 6 |
341.11 |
ml/kg |
83.37 |
204.21 |
liquid chromatography-mass spectrometry |
0.0 |
|
2 hour tail vein blood sampling |
ml/kg |
105714 |
3020 |
| SD |
nifedipine mean residence time |
nifedipine (200 ug/kg) |
Lu J, et al., Sci Rep. 2017 Feb 20;7:42922. doi: 10.1038/srep42922. |
xenobiotic pharmacokinetics trait |
both |
56.0 days
| 6 |
38.06 |
min |
5.41 |
13.25 |
liquid chromatography-mass spectrometry |
0.0 |
|
2 hour tail vein blood sampling |
mrt nifidepine |
105718 |
3020 |
| SD |
plasma nifedipine level |
nifedipine (200 ug/kg) |
Lu J, et al., Sci Rep. 2017 Feb 20;7:42922. doi: 10.1038/srep42922. |
blood xenobiotic amount |
both |
56.0 days
| 6 |
926.52 |
ng/ml |
142.87 |
349.96 |
liquid chromatography-mass spectrometry |
0.0 |
|
2 hour tail vein blood sampling |
intial concentration nifidepine |
105708 |
3020 |
| SD |
elimination half-life of nifedipine in the plasma |
nifedipine (200 ug/kg) |
Lu J, et al., Sci Rep. 2017 Feb 20;7:42922. doi: 10.1038/srep42922. |
xenobiotic pharmacokinetics trait |
both |
56.0 days
| 6 |
35.52 |
min |
8.29 |
20.31 |
liquid chromatography-mass spectrometry |
0.0 |
|
2 hour tail vein blood sampling |
1/2 life nifidepine |
105706 |
3020 |
| SD |
the first 120min of plasma nifedipine level area under curve |
nifedipine (200 ug/kg) |
Lu J, et al., Sci Rep. 2017 Feb 20;7:42922. doi: 10.1038/srep42922. |
blood xenobiotic amount |
both |
56.0 days
| 6 |
26979.23 |
min x (ng/ml) |
1522.03 |
3728.2 |
liquid chromatography-mass spectrometry |
0.0 |
|
2 hour tail vein blood sampling |
min x ng/ml |
105710 |
3020 |
| SD |
plasma nifedipine clearance |
nifedipine (200 ug/kg) |
Lu J, et al., Sci Rep. 2017 Feb 20;7:42922. doi: 10.1038/srep42922. |
xenobiotic pharmacokinetics trait |
both |
56.0 days
| 6 |
6.67 |
ml/min/kg |
0.51 |
1.25 |
liquid chromatography-mass spectrometry |
0.0 |
|
2 hour tail vein blood sampling |
cl nifidepine |
105716 |
3020 |
| SD |
plasma nifedipine level area under curve |
nifedipine (200 ug/kg) |
Lu J, et al., Sci Rep. 2017 Feb 20;7:42922. doi: 10.1038/srep42922. |
blood xenobiotic amount |
both |
56.0 days
| 6 |
30118.55 |
min x (ng/ml) |
2436.55 |
5968.3 |
liquid chromatography-mass spectrometry |
0.0 |
|
2 hour tail vein blood sampling |
min x ng/ml |
105712 |
3020 |
|