Phenominer Database Results (66 results)

 
 
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Strain Phenotype Conditions Study Experiment Name Sex Age # of Animals Value Units SEM SD Method Method Duration Post Insult Time Value Method Notes Clinical Measurement Notes Record ID Study ID
Crl:CD(SD) plasma AMG-8718 level area under curve (AUC) AMG-8718 (600 mg/kg) (for 24 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. blood enzyme inhibitor amount male 81.0 days-88.0 days 5 671000.0 ng/ml/h 84076.16 188000.0 liquid chromatography-mass spectrometry 0.0 samples at 0.5, 1.5, 5, 10, 24 hours auc 105433 3016
Crl:CD(SD) retinal outer layer thickness AMG-8718 (600 mg/kg) (for 13 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 67.0 days-74.0 days 5 132.1 um 3.18 7.1 ex vivo light microscopy with histochemistry and digital image analysis 0.0 optical coherence tomography outer retinal layer 105477 3016
Crl:CD(SD) full retina thickness AMG-8718 (100 mg/kg) (for 25 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 81.0 days-88.0 days 5 185.4 um 5.41 12.1 ex vivo light microscopy with histochemistry and digital image analysis 0.0 full retina layer 105448 3016
Crl:CD(SD) retinal outer nuclear layer photoreceptor nucleus count AMG-8718 (600 mg/kg) (for 25 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal outer nuclear layer morphology trait male 137.0 days-144.0 days 5 8.4 null 0.49 1.1 ex vivo light microscopy with histochemistry 0.0 nuclei per cell 105465 3016
Crl:CD(SD) retinal outer layer thickness AMG-8718 (10 mg/kg) (for 25 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 111.0 days-118.0 days 5 134.2 um 4.79 10.7 ex vivo light microscopy with histochemistry and digital image analysis 0.0 optical coherence tomography outer retinal layer 105491 3016
Crl:CD(SD) retinal outer layer thickness AMG-8718 (10 mg/kg) (for 25 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 136.0 days-143.0 days 5 128.2 um 3.8 8.5 ex vivo light microscopy with histochemistry and digital image analysis 0.0 optical coherence tomography outer retinal layer 105499 3016
Crl:CD(SD) retinal outer layer thickness AMG-8718 (100 mg/kg) (for 25 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 136.0 days-143.0 days 5 124.3 um 3.44 7.7 ex vivo light microscopy with histochemistry and digital image analysis 0.0 optical coherence tomography outer retinal layer 105500 3016
Crl:CD(SD) retinal outer nuclear layer thickness AMG-8718 (600 mg/kg) (for 5 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal outer nuclear layer morphology trait male 59.0 days-66.0 days 5 38.6 um 1.07 2.4 ex vivo light microscopy with histochemistry and digital image analysis 0.0 outer nuc layer 105437 3016
Crl:CD(SD) plasma AMG-8718 maximum concentration AMG-8718 (100 mg/kg) (for 4 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. blood enzyme inhibitor amount male 81.0 days-88.0 days 5 22500.0 ng/ml 1533.94 3430.0 liquid chromatography-mass spectrometry 0.0 max conc 105429 3016
Crl:CD(SD) plasma AMG-8718 maximum concentration AMG-8718 (600 mg/kg) (for 4 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. blood enzyme inhibitor amount male 59.0 days-66.0 days 5 39900.0 ng/ml 2575.95 5760.0 liquid chromatography-mass spectrometry 0.0 max conc 105424 3016
Crl:CD(SD) retinal outer nuclear layer thickness AMG-8718 (600 mg/kg) (for 25 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal outer nuclear layer morphology trait male 137.0 days-144.0 days 5 40.9 um 2.15 4.8 ex vivo light microscopy with histochemistry and digital image analysis 0.0 outer nuc layer 105457 3016
Crl:CD(SD) retinal inner layer thickness AMG-8718 (100 mg/kg) (for 5 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 59.0 days-66.0 days 5 125.4 um 3.53 7.9 optical coherence tomography 0.0 optical coherence tomography inner retinal layer 105472 3016
Crl:CD(SD) retinal inner layer thickness AMG-8718 (100 mg/kg) (for 13 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 67.0 days-74.0 days 5 128.6 um 4.11 9.2 ex vivo light microscopy with histochemistry and digital image analysis 0.0 optical coherence tomography inner retinal layer 105480 3016
Crl:CD(SD) retinal inner layer thickness AMG-8718 (100 mg/kg) (for 25 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 136.0 days-143.0 days 5 122.6 um 4.74 10.6 ex vivo light microscopy with histochemistry and digital image analysis 0.0 optical coherence tomography inner retinal layer 105504 3016
Crl:CD(SD) full retina thickness AMG-8718 (10 mg/kg) (for 25 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 81.0 days-88.0 days 5 175.9 um 9.17 20.5 ex vivo light microscopy with histochemistry and digital image analysis 0.0 full retina layer 105447 3016
Crl:CD(SD) retinal outer layer thickness AMG-8718 (100 mg/kg) (for 13 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 67.0 days-74.0 days 5 138.9 um 3.49 7.8 ex vivo light microscopy with histochemistry and digital image analysis 0.0 optical coherence tomography outer retinal layer 105476 3016
Crl:CD(SD) retinal outer nuclear layer thickness AMG-8718 (600 mg/kg) (for 25 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal outer nuclear layer morphology trait male 81.0 days-88.0 days 5 48.9 um 3.13 7.0 ex vivo light microscopy with histochemistry and digital image analysis 0.0 outer nuc layer 105445 3016
Crl:CD(SD) retinal outer nuclear layer photoreceptor nucleus count AMG-8718 (10 mg/kg) (for 25 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal outer nuclear layer morphology trait male 137.0 days-144.0 days 5 10.7 null 0.4 0.9 ex vivo light microscopy with histochemistry 0.0 nuclei per cell 105463 3016
Crl:CD(SD) retinal inner layer thickness AMG-8718 (10 mg/kg) (for 25 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 136.0 days-143.0 days 5 125.7 um 3.89 8.7 ex vivo light microscopy with histochemistry and digital image analysis 0.0 optical coherence tomography inner retinal layer 105503 3016
Crl:CD(SD) full retina thickness AMG-8718 (10 mg/kg) (for 5 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 59.0 days-66.0 days 5 128.0 um 4.74 10.6 ex vivo light microscopy with histochemistry and digital image analysis 0.0 full retina layer 105439 3016
Crl:CD(SD) retinal outer nuclear layer photoreceptor nucleus count AMG-8718 (10 mg/kg) (for 25 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal outer nuclear layer morphology trait male 81.0 days-88.0 days 5 11.3 null 0.32 0.72 ex vivo light microscopy with histochemistry 0.0 nuclei per cell 105451 3016
Crl:CD(SD) retinal inner layer thickness AMG-8718 (10 mg/kg) (for 13 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 67.0 days-74.0 days 5 127.2 um 3.85 8.6 ex vivo light microscopy with histochemistry and digital image analysis 0.0 optical coherence tomography inner retinal layer 105479 3016
Crl:CD(SD) retinal outer layer thickness AMG-8718 (100 mg/kg) (for 26 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 80.0 days-87.0 days 10 138.5 um 4.25 9.5 ex vivo light microscopy with histochemistry and digital image analysis 0.0 optical coherence tomography outer retinal layer 105484 3016
Crl:CD(SD) retinal outer nuclear layer thickness AMG-8718 (10 mg/kg) (for 5 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal outer nuclear layer morphology trait male 59.0 days-66.0 days 5 40.8 um 1.25 2.8 ex vivo light microscopy with histochemistry and digital image analysis 0.0 outer nuc layer 105435 3016
Crl:CD(SD) retinal outer nuclear layer thickness AMG-8718 (100 mg/kg) (for 25 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal outer nuclear layer morphology trait male 81.0 days-88.0 days 5 55.6 um 1.25 2.8 ex vivo light microscopy with histochemistry and digital image analysis 0.0 outer nuc layer 105444 3016
Crl:CD(SD) retinal outer nuclear layer thickness AMG-8718 (100 mg/kg) (for 25 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal outer nuclear layer morphology trait male 137.0 days-144.0 days 5 49.2 um 2.95 6.6 ex vivo light microscopy with histochemistry and digital image analysis 0.0 outer nuc layer 105456 3016
Crl:CD(SD) retinal outer layer thickness AMG-8718 (600 mg/kg) (for 26 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 80.0 days-87.0 days 10 133.4 um 3.04 6.8 ex vivo light microscopy with histochemistry and digital image analysis 0.0 optical coherence tomography outer retinal layer 105485 3016
Crl:CD(SD) retinal outer layer thickness AMG-8718 (100 mg/kg) (for 25 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 111.0 days-118.0 days 5 128.1 um 3.49 7.8 ex vivo light microscopy with histochemistry and digital image analysis 0.0 optical coherence tomography outer retinal layer 105492 3016
Crl:CD(SD) retinal inner layer thickness AMG-8718 (10 mg/kg) (for 25 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 111.0 days-118.0 days 5 126.1 um 4.11 9.2 ex vivo light microscopy with histochemistry and digital image analysis 0.0 optical coherence tomography inner retinal layer 105495 3016
Crl:CD(SD) plasma AMG-8718 level area under curve (AUC) AMG-8718 (100 mg/kg) (for 4 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. blood enzyme inhibitor amount male 59.0 days-66.0 days 5 221000.0 ng/ml/h 15831.36 35400.0 liquid chromatography-mass spectrometry 0.0 samples at 0.5, 1.5, 5, 10, 24 hours auc 105426 3016
Crl:CD(SD) retinal outer nuclear layer thickness AMG-8718 (100 mg/kg) (for 5 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal outer nuclear layer morphology trait male 59.0 days-66.0 days 5 38.5 um 1.07 2.4 ex vivo light microscopy with histochemistry and digital image analysis 0.0 outer nuc layer 105436 3016
Crl:CD(SD) plasma AMG-8718 level area under curve (AUC) AMG-8718 (600 mg/kg) (for 4 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. blood enzyme inhibitor amount male 59.0 days-66.0 days 5 549000.0 ng/ml/h 59479.41 133000.0 liquid chromatography-mass spectrometry 0.0 samples at 0.5, 1.5, 5, 10, 24 hours auc 105427 3016
Crl:CD(SD) full retina thickness AMG-8718 (100 mg/kg) (for 25 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 137.0 days-144.0 days 5 184.4 um 8.09 18.1 ex vivo light microscopy with histochemistry and digital image analysis 0.0 full retina layer 105460 3016
Crl:CD(SD) full retina thickness AMG-8718 (600 mg/kg) (for 25 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 137.0 days-144.0 days 5 167.0 um 6.98 15.6 ex vivo light microscopy with histochemistry and digital image analysis 0.0 full retina layer 105461 3016
Crl:CD(SD) retinal inner layer thickness AMG-8718 (600 mg/kg) (for 5 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 59.0 days-66.0 days 5 129.6 um 4.2 9.4 optical coherence tomography 0.0 optical coherence tomography inner retinal layer 105473 3016
Crl:CD(SD) retinal outer layer thickness AMG-8718 (600 mg/kg) (for 25 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 136.0 days-143.0 days 5 112.7 um 2.91 6.5 ex vivo light microscopy with histochemistry and digital image analysis 0.0 optical coherence tomography outer retinal layer 105501 3016
Crl:CD(SD) plasma AMG-8718 maximum concentration AMG-8718 (10 mg/kg) (for 4 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. blood enzyme inhibitor amount male 59.0 days-66.0 days 5 2730.0 ng/ml 287.11 642.0 liquid chromatography-mass spectrometry 0.0 max conc 105422 3016
Crl:CD(SD) retinal inner layer thickness AMG-8718 (600 mg/kg) (for 26 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 80.0 days-87.0 days 10 122.4 um 4.65 10.4 ex vivo light microscopy with histochemistry and digital image analysis 0.0 optical coherence tomography inner retinal layer 105489 3016
Crl:CD(SD) retinal inner layer thickness AMG-8718 (600 mg/kg) (for 25 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 111.0 days-118.0 days 5 120.9 um 5.19 11.6 ex vivo light microscopy with histochemistry and digital image analysis 0.0 optical coherence tomography inner retinal layer 105497 3016
Crl:CD(SD) plasma AMG-8718 level area under curve (AUC) AMG-8718 (10 mg/kg) (for 4 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. blood enzyme inhibitor amount male 59.0 days-66.0 days 5 15900.0 ng/ml/h 1507.11 3370.0 liquid chromatography-mass spectrometry 0.0 samples at 0.5, 1.5, 5, 10, 24 hours auc 105425 3016
Crl:CD(SD) plasma AMG-8718 maximum concentration AMG-8718 (600 mg/kg) (for 4 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. blood enzyme inhibitor amount male 59.0 days-66.0 days 5 50300.0 ng/ml 5321.84 11900.0 liquid chromatography-mass spectrometry 0.0 max conc 105430 3016
Crl:CD(SD) plasma AMG-8718 level area under curve (AUC) AMG-8718 (100 mg/kg) (for 24 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. blood enzyme inhibitor amount male 81.0 days-88.0 days 5 217000.0 ng/ml/h 10107.03 22600.0 liquid chromatography-mass spectrometry 0.0 samples at 0.5, 1.5, 5, 10, 24 hours auc 105432 3016
Crl:CD(SD) full retina thickness AMG-8718 (100 mg/kg) (for 5 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 59.0 days-66.0 days 5 122.2 um 4.07 9.1 ex vivo light microscopy with histochemistry and digital image analysis 0.0 full retina layer 105440 3016
Crl:CD(SD) full retina thickness AMG-8718 (600 mg/kg) (for 5 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 59.0 days-66.0 days 5 137.1 um 18.02 40.3 ex vivo light microscopy with histochemistry and digital image analysis 0.0 full retina layer 105441 3016
Crl:CD(SD) retinal outer nuclear layer photoreceptor nucleus count AMG-8718 (600 mg/kg) (for 25 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal outer nuclear layer morphology trait male 81.0 days-88.0 days 5 10.5 null 0.42 0.95 ex vivo light microscopy with histochemistry 0.0 nuclei per cell 105453 3016
Crl:CD(SD) full retina thickness AMG-8718 (600 mg/kg) (for 25 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 81.0 days-88.0 days 5 175.7 um 16.14 36.1 ex vivo light microscopy with histochemistry and digital image analysis 0.0 full retina layer 105449 3016
Crl:CD(SD) full retina thickness AMG-8718 (10 mg/kg) (for 25 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 137.0 days-144.0 days 5 207.4 um 18.87 42.2 ex vivo light microscopy with histochemistry and digital image analysis 0.0 full retina layer 105459 3016
Crl:CD(SD) retinal outer layer thickness AMG-8718 (600 mg/kg) (for 5 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 59.0 days-66.0 days 5 132.4 um 3.44 7.7 optical coherence tomography 0.0 optical coherence tomography outer retinal layer 105469 3016
Crl:CD(SD) retinal outer layer thickness AMG-8718 (10 mg/kg) (for 26 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 80.0 days-87.0 days 10 137.0 um 3.44 7.7 ex vivo light microscopy with histochemistry and digital image analysis 0.0 optical coherence tomography outer retinal layer 105483 3016
Crl:CD(SD) plasma AMG-8718 maximum concentration AMG-8718 (100 mg/kg) (for 4 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. blood enzyme inhibitor amount male 59.0 days-66.0 days 5 21500.0 ng/ml 1784.38 3990.0 liquid chromatography-mass spectrometry 0.0 max conc 105423 3016
Crl:CD(SD) retinal outer layer thickness AMG-8718 (10 mg/kg) (for 13 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 67.0 days-74.0 days 5 138.8 um 3.67 8.2 ex vivo light microscopy with histochemistry and digital image analysis 0.0 optical coherence tomography outer retinal layer 105475 3016
Crl:CD(SD) retinal inner layer thickness AMG-8718 (600 mg/kg) (for 13 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 67.0 days-74.0 days 5 124.0 um 4.2 9.4 ex vivo light microscopy with histochemistry and digital image analysis 0.0 optical coherence tomography inner retinal layer 105481 3016
Crl:CD(SD) retinal outer layer thickness AMG-8718 (600 mg/kg) (for 25 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 111.0 days-118.0 days 5 118.6 um 3.35 7.5 ex vivo light microscopy with histochemistry and digital image analysis 0.0 optical coherence tomography outer retinal layer 105493 3016
Crl:CD(SD) plasma AMG-8718 level area under curve (AUC) AMG-8718 (10 mg/kg) (for 24 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. blood enzyme inhibitor amount male 81.0 days-88.0 days 5 21800.0 ng/ml/h 2710.11 6060.0 liquid chromatography-mass spectrometry 0.0 samples at 0.5, 1.5, 5, 10, 24 hours auc 105431 3016
Crl:CD(SD) retinal outer nuclear layer thickness AMG-8718 (10 mg/kg) (for 25 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal outer nuclear layer morphology trait male 81.0 days-88.0 days 5 52.5 um 2.33 5.2 ex vivo light microscopy with histochemistry and digital image analysis 0.0 outer nuc layer 105443 3016
Crl:CD(SD) retinal outer layer thickness AMG-8718 (100 mg/kg) (for 5 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 59.0 days-66.0 days 5 134.5 um 3.35 7.5 optical coherence tomography 0.0 optical coherence tomography outer retinal layer 105468 3016
Crl:CD(SD) plasma AMG-8718 maximum concentration AMG-8718 (10 mg/kg) (for 4 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. blood enzyme inhibitor amount male 81.0 days-88.0 days 5 4450.0 ng/ml 496.41 1110.0 liquid chromatography-mass spectrometry 0.0 max conc 105428 3016
Crl:CD(SD) retinal outer nuclear layer photoreceptor nucleus count AMG-8718 (100 mg/kg) (for 25 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal outer nuclear layer morphology trait male 137.0 days-144.0 days 5 10.1 null 0.4 0.9 ex vivo light microscopy with histochemistry 0.0 nuclei per cell 105464 3016
Crl:CD(SD) retinal outer layer thickness AMG-8718 (10 mg/kg) (for 5 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 59.0 days-66.0 days 5 140.0 um 3.22 7.2 optical coherence tomography 0.0 optical coherence tomography outer retinal layer 105467 3016
Crl:CD(SD) retinal inner layer thickness AMG-8718 (100 mg/kg) (for 25 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 111.0 days-118.0 days 5 120.7 um 4.2 9.4 ex vivo light microscopy with histochemistry and digital image analysis 0.0 optical coherence tomography inner retinal layer 105496 3016
Crl:CD(SD) retinal outer nuclear layer photoreceptor nucleus count AMG-8718 (100 mg/kg) (for 25 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal outer nuclear layer morphology trait male 81.0 days-88.0 days 5 11.7 null 0.31 0.7 ex vivo light microscopy with histochemistry 0.0 nuclei per cell 105452 3016
Crl:CD(SD) retinal outer nuclear layer thickness AMG-8718 (10 mg/kg) (for 25 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal outer nuclear layer morphology trait male 137.0 days-144.0 days 5 51.1 um 1.65 3.7 ex vivo light microscopy with histochemistry and digital image analysis 0.0 outer nuc layer 105455 3016
Crl:CD(SD) retinal inner layer thickness AMG-8718 (10 mg/kg) (for 5 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 59.0 days-66.0 days 5 129.9 um 3.71 8.3 optical coherence tomography 0.0 optical coherence tomography inner retinal layer 105471 3016
Crl:CD(SD) retinal inner layer thickness AMG-8718 (10 mg/kg) (for 26 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 80.0 days-87.0 days 10 125.1 um 3.98 8.9 ex vivo light microscopy with histochemistry and digital image analysis 0.0 optical coherence tomography inner retinal layer 105487 3016
Crl:CD(SD) retinal inner layer thickness AMG-8718 (100 mg/kg) (for 26 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 80.0 days-87.0 days 10 124.7 um 3.89 8.7 ex vivo light microscopy with histochemistry and digital image analysis 0.0 optical coherence tomography inner retinal layer 105488 3016
Crl:CD(SD) retinal inner layer thickness AMG-8718 (600 mg/kg) (for 25 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 136.0 days-143.0 days 5 120.4 um 4.25 9.5 ex vivo light microscopy with histochemistry and digital image analysis 0.0 optical coherence tomography inner retinal layer 105505 3016