| Crl:CD(SD) |
plasma alanine aminotransferase activity level |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood alanine transaminase amount |
male |
78.0 days
| 19 |
35.0 |
U/l |
1.49 |
6.5 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85429 |
1604 |
| Crl:CD(SD) |
plasma glutamate dehydrogenase activity level |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood glutamate dehydrogenase amount |
male |
133.0 days
| 19 |
13.4 |
U/l |
0.3 |
1.3 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85453 |
1604 |
| Crl:CD(SD) |
food intake weight to body weight ratio |
standard diet and restricted feeding (4 h) then acetaminophen (300 mg/kg) (for 77 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
147.0 days
| 8 |
4.37 |
g/d/100g |
0.23 |
0.66 |
unspecified method |
0.0 |
|
|
|
|
on days 74-77 |
85510 |
1604 |
| Crl:CD(SD) |
body weight |
standard diet and restricted feeding (4 h) then acetaminophen (500 mg/kg) (for 1 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
body mass |
male |
71.0 days
| 8 |
287.0 |
g |
5.3 |
15.0 |
body weighing method |
0.0 |
|
|
|
|
|
85523 |
1604 |
| Crl:CD(SD) |
body weight |
standard diet and restricted feeding (4 h) then acetaminophen (300 mg/kg) (for 98 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
body mass |
male |
168.0 days
| 8 |
447.0 |
g |
16.62 |
47.0 |
body weighing method |
0.0 |
|
|
|
|
|
85552 |
1604 |
| Crl:CD(SD) |
food intake rate |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
105.0 days
| 19 |
17.2 |
g/d |
0.6 |
2.6 |
unspecified method |
0.0 |
|
|
|
|
|
85293 |
1604 |
| Crl:CD(SD) |
food intake rate |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
126.0 days
| 19 |
20.1 |
g/d |
0.5 |
2.2 |
unspecified method |
0.0 |
|
|
|
|
|
85295 |
1604 |
| Crl:CD(SD) |
body weight |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
body mass |
male |
147.0 days
| 19 |
430.0 |
g |
5.96 |
26.0 |
body weighing method |
0.0 |
|
|
|
|
|
85319 |
1604 |
| Crl:CD(SD) |
body weight |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
body mass |
male |
168.0 days
| 19 |
444.0 |
g |
6.65 |
29.0 |
body weighing method |
0.0 |
|
|
|
|
|
85321 |
1604 |
| Crl:CD(SD) |
plasma lactate level |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood lactate amount |
male |
133.0 days
| 19 |
30.2 |
mg/dl |
2.87 |
12.5 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85365 |
1604 |
| Crl:CD(SD) |
urine creatine excretion rate |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
urine creatine amount |
male |
106.0 days
| 19 |
1.71 |
umol/d |
0.09 |
0.39 |
liquid chromatography-mass spectrometry |
0.0 |
|
|
|
|
|
85381 |
1604 |
| Crl:CD(SD) |
plasma aspartate aminotransferase activity level |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood aspartate transaminase amount |
male |
70.0 days
| 19 |
61.8 |
U/l |
1.26 |
5.5 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85411 |
1604 |
| Crl:CD(SD) |
food intake rate |
standard diet and restricted feeding (4 h) then acetaminophen (300 mg/kg) (for 98 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
168.0 days
| 8 |
18.3 |
g/d |
1.98 |
5.6 |
unspecified method |
0.0 |
|
|
|
|
|
85486 |
1604 |
| Crl:CD(SD) |
body weight |
standard diet and restricted feeding (4 h) then acetaminophen (300 mg/kg) (for 1 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
body mass |
male |
71.0 days
| 8 |
287.0 |
g |
6.72 |
19.0 |
body weighing method |
0.0 |
|
|
|
|
|
85522 |
1604 |
| Crl:CD(SD) |
liver wet weight |
standard diet and restricted feeding (4 h) (for 114 days) then acetaminophen (500 mg/kg) (for 99 days) then fasting (for 20 hours) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
liver mass |
male |
170.0 days
| 8 |
12.8 |
g |
0.22 |
0.61 |
unspecified method |
0.0 |
|
|
|
|
|
85559 |
1604 |
| Crl:CD(SD) |
food intake rate |
standard diet and restricted feeding (4 h) then acetaminophen (300 mg/kg) (for 56 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
126.0 days
| 8 |
22.1 |
g/d |
0.71 |
2.0 |
unspecified method |
0.0 |
|
|
|
|
|
85474 |
1604 |
| Crl:CD(SD) |
food intake weight to body weight ratio |
standard diet and restricted feeding (4 h) then acetaminophen (500 mg/kg) (for 77 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
147.0 days
| 8 |
4.03 |
g/d/100g |
0.29 |
0.81 |
unspecified method |
0.0 |
|
|
|
|
on days 74-77 |
85511 |
1604 |
| Crl:CD(SD) |
plasma acetaminophen level area under curve |
standard diet and restricted feeding (4 h) (for 114 days) then acetaminophen (500 mg/kg) (for 99 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood acetaminophen amount |
male |
170.0 days
| 8 |
500.6 |
(ug/ml) x h |
64.42 |
182.2 |
high-performance liquid chromatography |
0.0 |
acetaminophen dosing |
1140 |
min |
4-19 hr dosing |
4-19 hr dosing |
85589 |
1604 |
| Crl:CD(SD) |
food intake weight to body weight ratio |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
84.0 days
| 19 |
6.11 |
g/d/100g |
0.1 |
0.45 |
unspecified method |
0.0 |
|
|
|
|
|
85301 |
1604 |
| Crl:CD(SD) |
plasma glucose level |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood glucose amount |
male |
105.0 days
| 19 |
121.0 |
mg/dl |
1.61 |
7.0 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85329 |
1604 |
| Crl:CD(SD) |
plasma pyruvate level |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood pyruvate amount |
male |
147.0 days
| 19 |
0.68 |
mg/dl |
0.1 |
0.42 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85351 |
1604 |
| Crl:CD(SD) |
plasma aspartate aminotransferase activity level |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood aspartate transaminase amount |
male |
133.0 days
| 19 |
57.6 |
U/l |
1.58 |
6.9 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85421 |
1604 |
| Crl:CD(SD) |
plasma glutamate dehydrogenase activity level |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood glutamate dehydrogenase amount |
male |
168.0 days
| 19 |
12.8 |
U/l |
0.69 |
3.0 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85457 |
1604 |
| Crl:CD(SD) |
food intake rate |
standard diet and restricted feeding (4 h) then acetaminophen (500 mg/kg) (for 35 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
105.0 days
| 8 |
16.7 |
g/d |
0.95 |
2.7 |
unspecified method |
0.0 |
|
|
|
|
|
85469 |
1604 |
| Crl:CD(SD) |
food intake weight to body weight ratio |
standard diet and restricted feeding (4 h) then acetaminophen (300 mg/kg) (for 14 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
84.0 days
| 8 |
6.04 |
g/d/100g |
0.21 |
0.58 |
unspecified method |
0.0 |
|
|
|
|
on days 11-14 |
85492 |
1604 |
| Crl:CD(SD) |
food intake rate |
standard diet and restricted feeding (4 h) then acetaminophen (500 mg/kg) (for 98 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
168.0 days
| 8 |
16.6 |
g/d |
0.95 |
2.7 |
unspecified method |
0.0 |
|
|
|
|
|
85487 |
1604 |
| Crl:CD(SD) |
food intake rate |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
147.0 days
| 19 |
19.4 |
g/d |
0.87 |
3.8 |
unspecified method |
0.0 |
|
|
|
|
|
85297 |
1604 |
| Crl:CD(SD) |
food intake weight to body weight ratio |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
126.0 days
| 19 |
4.62 |
g/d/100g |
0.13 |
0.56 |
unspecified method |
0.0 |
|
|
|
|
|
85305 |
1604 |
| Crl:CD(SD) |
plasma lactate level |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood lactate amount |
male |
78.0 days
| 19 |
18.7 |
mg/dl |
1.28 |
5.6 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85357 |
1604 |
| Crl:CD(SD) |
plasma alanine aminotransferase activity level |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood alanine transaminase amount |
male |
105.0 days
| 19 |
34.0 |
U/l |
1.35 |
5.9 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85433 |
1604 |
| Crl:CD(SD) |
body weight |
standard diet and restricted feeding (4 h) then acetaminophen (300 mg/kg) (for 14 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
body mass |
male |
84.0 days
| 8 |
333.0 |
g |
8.13 |
23.0 |
body weighing method |
0.0 |
|
|
|
|
|
85528 |
1604 |
| Crl:CD(SD) |
body weight |
standard diet and restricted feeding (4 h) then acetaminophen (300 mg/kg) (for 35 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
body mass |
male |
105.0 days
| 8 |
375.0 |
g |
12.73 |
36.0 |
body weighing method |
0.0 |
|
|
|
|
|
85534 |
1604 |
| Crl:CD(SD) |
body weight |
standard diet and restricted feeding (4 h) then acetaminophen (500 mg/kg) (for 35 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
body mass |
male |
105.0 days
| 8 |
365.0 |
g |
6.36 |
18.0 |
body weighing method |
0.0 |
|
|
|
|
|
85535 |
1604 |
| Crl:CD(SD) |
liver reduced glutathione level to liver weight ratio |
standard diet and restricted feeding (4 h) (for 114 days) then acetaminophen (500 mg/kg) (for 99 days) then fasting (for 20 hours) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
liver glutathione amount |
male |
170.0 days
| 8 |
5.19 |
umol/g |
0.24 |
0.69 |
reduced glutathione/oxidized glutathione enzyme recycling assay |
0.0 |
|
|
|
enzyme recycling method |
|
85571 |
1604 |
| Crl:CD(SD) |
plasma pyruvate level |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood pyruvate amount |
male |
119.0 days
| 19 |
0.94 |
mg/dl |
0.09 |
0.39 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85347 |
1604 |
| Crl:CD(SD) |
urine creatinine excretion rate |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
urine creatinine amount |
male |
70.0 days
| 19 |
7.64 |
mg/d |
0.27 |
1.17 |
liquid chromatography-mass spectrometry |
0.0 |
|
|
|
|
|
85387 |
1604 |
| Crl:CD(SD) |
plasma glucose level |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood glucose amount |
male |
78.0 days
| 19 |
126.0 |
mg/dl |
2.06 |
9.0 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85325 |
1604 |
| Crl:CD(SD) |
plasma pyruvate level |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood pyruvate amount |
male |
168.0 days
| 19 |
0.56 |
mg/dl |
0.03 |
0.15 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85353 |
1604 |
| Crl:CD(SD) |
plasma lactate level |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood lactate amount |
male |
91.0 days
| 19 |
25.2 |
mg/dl |
2.09 |
9.1 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85359 |
1604 |
| Crl:CD(SD) |
urine taurine excretion rate |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
urine taurine amount |
male |
106.0 days
| 19 |
142.0 |
umol/d |
12.64 |
55.1 |
liquid chromatography-mass spectrometry |
0.0 |
|
|
|
|
|
85397 |
1604 |
| Crl:CD(SD) |
urine taurine excretion rate |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
urine taurine amount |
male |
169.0 days
| 19 |
153.1 |
umol/d |
7.75 |
33.8 |
liquid chromatography-mass spectrometry |
0.0 |
|
|
|
|
|
85401 |
1604 |
| Crl:CD(SD) |
plasma alanine aminotransferase activity level |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood alanine transaminase amount |
male |
168.0 days
| 19 |
33.2 |
U/l |
1.1 |
4.8 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85441 |
1604 |
| Crl:CD(SD) |
body weight |
standard diet and restricted feeding (4 h) then acetaminophen (300 mg/kg) (for 77 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
body mass |
male |
147.0 days
| 8 |
432.0 |
g |
17.32 |
49.0 |
body weighing method |
0.0 |
|
|
|
|
|
85546 |
1604 |
| Crl:CD(SD) |
plasma aspartate aminotransferase activity level |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood aspartate transaminase amount |
male |
168.0 days
| 19 |
48.1 |
U/l |
0.69 |
3.0 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85425 |
1604 |
| Crl:CD(SD) |
food intake weight to body weight ratio |
standard diet and restricted feeding (4 h) then acetaminophen (300 mg/kg) (for 98 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
168.0 days
| 8 |
3.96 |
g/d/100g |
0.35 |
0.98 |
unspecified method |
0.0 |
|
|
|
|
on days 95-98 |
85516 |
1604 |
| Crl:CD(SD) |
food intake rate |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
84.0 days
| 19 |
17.0 |
g/d |
0.73 |
3.2 |
unspecified method |
0.0 |
|
|
|
|
|
85292 |
1604 |
| Crl:CD(SD) |
food intake weight to body weight ratio |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
105.0 days
| 19 |
5.36 |
g/d/100g |
0.15 |
0.65 |
unspecified method |
0.0 |
|
|
|
|
|
85303 |
1604 |
| Crl:CD(SD) |
body weight |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
body mass |
male |
105.0 days
| 19 |
374.0 |
g |
5.28 |
23.0 |
body weighing method |
0.0 |
|
|
|
|
|
85315 |
1604 |
| Crl:CD(SD) |
plasma pyruvate level |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood pyruvate amount |
male |
78.0 days
| 19 |
0.69 |
mg/dl |
0.15 |
0.64 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85341 |
1604 |
| Crl:CD(SD) |
plasma creatinine level |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood creatinine amount |
male |
105.0 days
| 19 |
0.41 |
mg/dl |
0.01 |
0.03 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85373 |
1604 |
| Crl:CD(SD) |
plasma lactate level |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood lactate amount |
male |
147.0 days
| 19 |
19.4 |
mg/dl |
0.78 |
3.4 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85367 |
1604 |
| Crl:CD(SD) |
food intake rate |
standard diet and restricted feeding (4 h) then acetaminophen (300 mg/kg) (for 14 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
84.0 days
| 8 |
20.3 |
g/d |
1.06 |
3.0 |
unspecified method |
0.0 |
|
|
|
|
|
85462 |
1604 |
| Crl:CD(SD) |
food intake rate |
standard diet and restricted feeding (4 h) then acetaminophen (500 mg/kg) (for 14 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
84.0 days
| 8 |
18.8 |
g/d |
0.92 |
2.6 |
unspecified method |
0.0 |
|
|
|
|
|
85463 |
1604 |
| Crl:CD(SD) |
food intake weight to body weight ratio |
standard diet and restricted feeding (4 h) then acetaminophen (300 mg/kg) (for 56 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
126.0 days
| 8 |
4.38 |
g/d/100g |
0.31 |
0.87 |
unspecified method |
0.0 |
|
|
|
|
on days 53-56 |
85504 |
1604 |
| Crl:CD(SD) |
plasma acetaminophen level |
standard diet and restricted feeding (4 h) (for 114 days) then acetaminophen (500 mg/kg) (for 99 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood acetaminophen amount |
male |
170.0 days
| 8 |
2.4 |
ug/ml |
0.71 |
2.0 |
high-performance liquid chromatography |
0.0 |
acetaminophen dosing |
1140 |
min |
|
19 hr after dosing |
85585 |
1604 |
| Crl:CD(SD) |
plasma acetaminophen level area under curve |
standard diet and restricted feeding (4 h) (for 114 days) then acetaminophen (300 mg/kg) (for 99 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood acetaminophen amount |
male |
170.0 days
| 8 |
373.9 |
(ug/ml) x h |
38.93 |
110.1 |
high-performance liquid chromatography |
0.0 |
acetaminophen dosing |
1140 |
min |
4-19 hr dosing |
4-19 hr dosing |
85588 |
1604 |
| Crl:CD(SD) |
body weight |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
body mass |
male |
84.0 days
| 19 |
328.0 |
g |
4.82 |
21.0 |
body weighing method |
0.0 |
|
|
|
|
|
85313 |
1604 |
| Crl:CD(SD) |
plasma pyruvate level |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood pyruvate amount |
male |
91.0 days
| 19 |
1.0 |
mg/dl |
0.08 |
0.35 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85343 |
1604 |
| Crl:CD(SD) |
urine creatine excretion rate |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
urine creatine amount |
male |
169.0 days
| 19 |
2.06 |
umol/d |
0.12 |
0.51 |
liquid chromatography-mass spectrometry |
0.0 |
|
|
|
|
|
85385 |
1604 |
| Crl:CD(SD) |
urine taurine excretion rate |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
urine taurine amount |
male |
134.0 days
| 19 |
171.1 |
umol/d |
13.08 |
57.0 |
liquid chromatography-mass spectrometry |
0.0 |
|
|
|
|
|
85399 |
1604 |
| Crl:CD(SD) |
food intake weight to body weight ratio |
standard diet and restricted feeding (4 h) then acetaminophen (500 mg/kg) (for 35 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
105.0 days
| 8 |
4.9 |
g/d/100g |
0.18 |
0.5 |
unspecified method |
0.0 |
|
|
|
|
on days 32-35 |
85499 |
1604 |
| Crl:CD(SD) |
liver wet weight |
standard diet and restricted feeding (4 h) (for 114 days) then acetaminophen (300 mg/kg) (for 99 days) then fasting (for 20 hours) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
liver mass |
male |
170.0 days
| 8 |
12.2 |
g |
0.77 |
2.17 |
unspecified method |
0.0 |
|
|
|
|
|
85558 |
1604 |
| Crl:CD(SD) |
plasma alanine aminotransferase activity level |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood alanine transaminase amount |
male |
70.0 days
| 19 |
35.3 |
U/l |
1.03 |
4.5 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85427 |
1604 |
| Crl:CD(SD) |
plasma glutamate dehydrogenase activity level |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood glutamate dehydrogenase amount |
male |
105.0 days
| 19 |
13.5 |
U/l |
0.21 |
0.9 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85449 |
1604 |
| Crl:CD(SD) |
liver oxidized glutathione level to liver weight ratio |
standard diet and restricted feeding (4 h) (for 114 days) then acetaminophen (300 mg/kg) (for 99 days) then fasting (for 20 hours) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
liver glutathione amount |
male |
170.0 days
| 8 |
0.16 |
umol/g |
0.01 |
0.03 |
reduced glutathione/oxidized glutathione enzyme recycling assay |
0.0 |
|
|
|
enzyme recycling method |
|
85576 |
1604 |
| Crl:CD(SD) |
food intake weight to body weight ratio |
standard diet and restricted feeding (4 h) then acetaminophen (500 mg/kg) (for 14 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
84.0 days
| 8 |
6.04 |
g/d/100g |
0.23 |
0.66 |
unspecified method |
0.0 |
|
|
|
|
on days 11-14 |
85493 |
1604 |
| Crl:CD(SD) |
food intake rate |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
168.0 days
| 19 |
17.2 |
g/d |
0.83 |
3.6 |
unspecified method |
0.0 |
|
|
|
|
|
85299 |
1604 |
| Crl:CD(SD) |
body weight |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
body mass |
male |
126.0 days
| 19 |
401.0 |
g |
4.82 |
21.0 |
body weighing method |
0.0 |
|
|
|
|
|
85317 |
1604 |
| Crl:CD(SD) |
plasma pyruvate level |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood pyruvate amount |
male |
70.0 days
| 19 |
0.57 |
mg/dl |
0.04 |
0.18 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85339 |
1604 |
| Crl:CD(SD) |
urine creatine excretion rate |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
urine creatine amount |
male |
70.0 days
| 19 |
1.05 |
umol/d |
0.04 |
0.19 |
liquid chromatography-mass spectrometry |
0.0 |
|
|
|
|
|
85379 |
1604 |
| Crl:CD(SD) |
urine creatinine excretion rate |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
urine creatinine amount |
male |
134.0 days
| 19 |
12.5 |
mg/d |
0.25 |
1.11 |
liquid chromatography-mass spectrometry |
0.0 |
|
|
|
|
|
85391 |
1604 |
| Crl:CD(SD) |
urine creatinine excretion rate |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
urine creatinine amount |
male |
169.0 days
| 19 |
12.28 |
mg/d |
0.58 |
2.51 |
liquid chromatography-mass spectrometry |
0.0 |
|
|
|
|
|
85393 |
1604 |
| Crl:CD(SD) |
liver reduced glutathione level to liver weight ratio |
standard diet and restricted feeding (4 h) (for 114 days) then fasting (for 20 hours) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
liver glutathione amount |
male |
170.0 days
| 19 |
6.1 |
umol/g |
0.15 |
0.67 |
reduced glutathione/oxidized glutathione enzyme recycling assay |
0.0 |
|
|
|
enzyme recycling method |
|
85407 |
1604 |
| Crl:CD(SD) |
plasma aspartate aminotransferase activity level |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood aspartate transaminase amount |
male |
91.0 days
| 19 |
59.7 |
U/l |
0.8 |
3.5 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85415 |
1604 |
| Crl:CD(SD) |
plasma aspartate aminotransferase activity level |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood aspartate transaminase amount |
male |
105.0 days
| 19 |
58.4 |
U/l |
1.06 |
4.6 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85417 |
1604 |
| Crl:CD(SD) |
plasma alanine aminotransferase activity level |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood alanine transaminase amount |
male |
91.0 days
| 19 |
35.4 |
U/l |
1.49 |
6.5 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85431 |
1604 |
| Crl:CD(SD) |
plasma glutamate dehydrogenase activity level |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood glutamate dehydrogenase amount |
male |
78.0 days
| 19 |
17.9 |
U/l |
1.61 |
7.0 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85445 |
1604 |
| Crl:CD(SD) |
plasma glutamate dehydrogenase activity level |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood glutamate dehydrogenase amount |
male |
91.0 days
| 19 |
15.5 |
U/l |
0.62 |
2.7 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85447 |
1604 |
| Crl:CD(SD) |
plasma glutamate dehydrogenase activity level |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood glutamate dehydrogenase amount |
male |
119.0 days
| 19 |
15.0 |
U/l |
0.55 |
2.4 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85451 |
1604 |
| Crl:CD(SD) |
plasma glutamate dehydrogenase activity level |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood glutamate dehydrogenase amount |
male |
147.0 days
| 19 |
13.4 |
U/l |
0.41 |
1.8 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85455 |
1604 |
| Crl:CD(SD) |
food intake rate |
standard diet and restricted feeding (4 h) then acetaminophen (300 mg/kg) (for 35 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
105.0 days
| 8 |
18.2 |
g/d |
1.13 |
3.2 |
unspecified method |
0.0 |
|
|
|
|
|
85468 |
1604 |
| Crl:CD(SD) |
food intake weight to body weight ratio |
standard diet and restricted feeding (4 h) then acetaminophen (300 mg/kg) (for 35 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
105.0 days
| 8 |
5.09 |
g/d/100g |
0.24 |
0.67 |
unspecified method |
0.0 |
|
|
|
|
on days 32-35 |
85498 |
1604 |
| Crl:CD(SD) |
food intake weight to body weight ratio |
standard diet and restricted feeding (4 h) then acetaminophen (500 mg/kg) (for 56 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
126.0 days
| 8 |
4.23 |
g/d/100g |
0.27 |
0.77 |
unspecified method |
0.0 |
|
|
|
|
on days 53-56 |
85505 |
1604 |
| Crl:CD(SD) |
body weight |
standard diet and restricted feeding (4 h) then acetaminophen (500 mg/kg) (for 14 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
body mass |
male |
84.0 days
| 8 |
321.0 |
g |
7.78 |
22.0 |
body weighing method |
0.0 |
|
|
|
|
|
85529 |
1604 |
| Crl:CD(SD) |
body weight |
standard diet and restricted feeding (4 h) then acetaminophen (300 mg/kg) (for 56 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
body mass |
male |
126.0 days
| 8 |
404.0 |
g |
12.37 |
35.0 |
body weighing method |
0.0 |
|
|
|
|
|
85540 |
1604 |
| Crl:CD(SD) |
plasma pyruvate level |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood pyruvate amount |
male |
133.0 days
| 19 |
0.91 |
mg/dl |
0.1 |
0.43 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85349 |
1604 |
| Crl:CD(SD) |
food intake weight to body weight ratio |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
168.0 days
| 19 |
4.01 |
g/d/100g |
0.27 |
1.17 |
unspecified method |
0.0 |
|
|
|
|
|
85309 |
1604 |
| Crl:CD(SD) |
food intake weight to body weight ratio |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
147.0 days
| 19 |
4.18 |
g/d/100g |
0.19 |
0.84 |
unspecified method |
0.0 |
|
|
|
|
|
85307 |
1604 |
| Crl:CD(SD) |
plasma glucose level |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood glucose amount |
male |
91.0 days
| 19 |
124.0 |
mg/dl |
2.29 |
10.0 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85327 |
1604 |
| Crl:CD(SD) |
plasma creatinine level |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood creatinine amount |
male |
70.0 days
| 19 |
0.38 |
mg/dl |
0.0 |
0.02 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85371 |
1604 |
| Crl:CD(SD) |
plasma creatinine level |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood creatinine amount |
male |
133.0 days
| 19 |
0.41 |
mg/dl |
0.01 |
0.04 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85375 |
1604 |
| Crl:CD(SD) |
liver wet weight |
standard diet and restricted feeding (4 h) (for 114 days) then fasting (for 20 hours) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
liver mass |
male |
170.0 days
| 19 |
11.09 |
g |
0.16 |
0.71 |
unspecified method |
0.0 |
|
|
|
|
|
85403 |
1604 |
| Crl:CD(SD) |
plasma alanine aminotransferase activity level |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood alanine transaminase amount |
male |
119.0 days
| 19 |
36.8 |
U/l |
1.19 |
5.2 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85435 |
1604 |
| Crl:CD(SD) |
plasma glucose level |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood glucose amount |
male |
119.0 days
| 19 |
127.0 |
mg/dl |
1.84 |
8.0 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85331 |
1604 |
| Crl:CD(SD) |
liver reduced glutathione level to liver weight ratio |
standard diet and restricted feeding (4 h) (for 114 days) then acetaminophen (300 mg/kg) (for 99 days) then fasting (for 20 hours) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
liver glutathione amount |
male |
170.0 days
| 8 |
6.24 |
umol/g |
0.31 |
0.87 |
reduced glutathione/oxidized glutathione enzyme recycling assay |
0.0 |
|
|
|
enzyme recycling method |
|
85570 |
1604 |
| Crl:CD(SD) |
plasma aspartate aminotransferase activity level |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood aspartate transaminase amount |
male |
147.0 days
| 19 |
54.3 |
U/l |
1.26 |
5.5 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85423 |
1604 |
| Crl:CD(SD) |
food intake rate |
standard diet and restricted feeding (4 h) then acetaminophen (500 mg/kg) (for 56 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
126.0 days
| 8 |
18.7 |
g/d |
1.45 |
4.1 |
unspecified method |
0.0 |
|
|
|
|
|
85475 |
1604 |
| Crl:CD(SD) |
body weight |
standard diet and restricted feeding (4 h) then acetaminophen (500 mg/kg) (for 77 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
body mass |
male |
147.0 days
| 8 |
431.0 |
g |
8.49 |
24.0 |
body weighing method |
0.0 |
|
|
|
|
|
85547 |
1604 |
| Crl:CD(SD) |
plasma alanine aminotransferase activity level |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood alanine transaminase amount |
male |
133.0 days
| 19 |
32.4 |
U/l |
0.99 |
4.3 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85437 |
1604 |
| Crl:CD(SD) |
food intake rate |
standard diet and restricted feeding (4 h) then acetaminophen (300 mg/kg) (for 77 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
147.0 days
| 8 |
17.9 |
g/d |
1.77 |
5.0 |
unspecified method |
0.0 |
|
|
|
|
|
85480 |
1604 |
| Crl:CD(SD) |
plasma lactate level |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood lactate amount |
male |
70.0 days
| 19 |
14.7 |
mg/dl |
1.1 |
4.8 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85355 |
1604 |
| Crl:CD(SD) |
plasma lactate level |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood lactate amount |
male |
119.0 days
| 19 |
33.2 |
mg/dl |
3.4 |
14.8 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85363 |
1604 |
| Crl:CD(SD) |
plasma creatinine level |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood creatinine amount |
male |
168.0 days
| 19 |
0.46 |
mg/dl |
0.0 |
0.02 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85377 |
1604 |
| Crl:CD(SD) |
urine creatinine excretion rate |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
urine creatinine amount |
male |
106.0 days
| 19 |
11.98 |
mg/d |
0.42 |
1.84 |
liquid chromatography-mass spectrometry |
0.0 |
|
|
|
|
|
85389 |
1604 |
| Crl:CD(SD) |
urine taurine excretion rate |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
urine taurine amount |
male |
70.0 days
| 19 |
58.1 |
umol/d |
5.41 |
23.6 |
liquid chromatography-mass spectrometry |
0.0 |
|
|
|
|
|
85395 |
1604 |
| Crl:CD(SD) |
liver oxidized glutathione level to liver weight ratio |
standard diet and restricted feeding (4 h) (for 114 days) then fasting (for 20 hours) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
liver glutathione amount |
male |
170.0 days
| 19 |
0.17 |
umol/g |
0.0 |
0.02 |
reduced glutathione/oxidized glutathione enzyme recycling assay |
0.0 |
|
|
|
enzyme recycling method |
|
85409 |
1604 |
| Crl:CD(SD) |
plasma aspartate aminotransferase activity level |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood aspartate transaminase amount |
male |
78.0 days
| 19 |
59.1 |
U/l |
1.28 |
5.6 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85413 |
1604 |
| Crl:CD(SD) |
food intake rate |
standard diet and restricted feeding (4 h) then acetaminophen (500 mg/kg) (for 77 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
147.0 days
| 8 |
17.7 |
g/d |
1.31 |
3.7 |
unspecified method |
0.0 |
|
|
|
|
|
85481 |
1604 |
| Crl:CD(SD) |
body weight |
standard diet and restricted feeding (4 h) then acetaminophen (500 mg/kg) (for 56 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
body mass |
male |
126.0 days
| 8 |
400.0 |
g |
7.78 |
22.0 |
body weighing method |
0.0 |
|
|
|
|
|
85541 |
1604 |
| Crl:CD(SD) |
body weight |
standard diet and restricted feeding (4 h) then acetaminophen (500 mg/kg) (for 98 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
body mass |
male |
168.0 days
| 8 |
440.0 |
g |
9.19 |
26.0 |
body weighing method |
0.0 |
|
|
|
|
|
85553 |
1604 |
| Crl:CD(SD) |
plasma acetaminophen level |
standard diet and restricted feeding (4 h) (for 114 days) then acetaminophen (300 mg/kg) (for 99 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood acetaminophen amount |
male |
170.0 days
| 8 |
0.6 |
ug/ml |
0.21 |
0.6 |
high-performance liquid chromatography |
0.0 |
acetaminophen dosing |
1140 |
min |
|
19 hr after dosing |
85584 |
1604 |
| Crl:CD(SD) |
plasma glucose level |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood glucose amount |
male |
168.0 days
| 19 |
128.0 |
mg/dl |
1.84 |
8.0 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85337 |
1604 |
| Crl:CD(SD) |
body weight |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
body mass |
male |
71.0 days
| 19 |
288.0 |
g |
3.67 |
16.0 |
body weighing method |
0.0 |
|
|
|
|
|
85311 |
1604 |
| Crl:CD(SD) |
plasma glucose level |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood glucose amount |
male |
70.0 days
| 19 |
117.0 |
mg/dl |
1.84 |
8.0 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85323 |
1604 |
| Crl:CD(SD) |
plasma glucose level |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood glucose amount |
male |
133.0 days
| 19 |
124.0 |
mg/dl |
1.61 |
7.0 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85333 |
1604 |
| Crl:CD(SD) |
plasma glucose level |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood glucose amount |
male |
147.0 days
| 19 |
126.0 |
mg/dl |
1.84 |
8.0 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85335 |
1604 |
| Crl:CD(SD) |
plasma pyruvate level |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood pyruvate amount |
male |
105.0 days
| 19 |
0.81 |
mg/dl |
0.06 |
0.27 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85345 |
1604 |
| Crl:CD(SD) |
plasma lactate level |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood lactate amount |
male |
105.0 days
| 19 |
23.5 |
mg/dl |
2.29 |
10.0 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85361 |
1604 |
| Crl:CD(SD) |
plasma lactate level |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood lactate amount |
male |
168.0 days
| 19 |
18.9 |
mg/dl |
1.67 |
7.3 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85369 |
1604 |
| Crl:CD(SD) |
urine creatine excretion rate |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
urine creatine amount |
male |
134.0 days
| 19 |
2.0 |
umol/d |
0.13 |
0.57 |
liquid chromatography-mass spectrometry |
0.0 |
|
|
|
|
|
85383 |
1604 |
| Crl:CD(SD) |
plasma aspartate aminotransferase activity level |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood aspartate transaminase amount |
male |
119.0 days
| 19 |
58.8 |
U/l |
1.54 |
6.7 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85419 |
1604 |
| Crl:CD(SD) |
plasma alanine aminotransferase activity level |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood alanine transaminase amount |
male |
147.0 days
| 19 |
34.4 |
U/l |
1.31 |
5.7 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85439 |
1604 |
| Crl:CD(SD) |
plasma glutamate dehydrogenase activity level |
standard diet and restricted feeding (4 h) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood glutamate dehydrogenase amount |
male |
70.0 days
| 19 |
15.9 |
U/l |
1.17 |
5.1 |
automated blood analysis |
0.0 |
|
|
|
TBA-120FR, Toshiba corporation, Japan |
|
85443 |
1604 |
| Crl:CD(SD) |
food intake weight to body weight ratio |
standard diet and restricted feeding (4 h) then acetaminophen (500 mg/kg) (for 98 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
168.0 days
| 8 |
4.34 |
g/d/100g |
0.34 |
0.96 |
unspecified method |
0.0 |
|
|
|
|
on days 95-98 |
85517 |
1604 |
| Crl:CD(SD) |
plasma acetaminophen level |
standard diet and restricted feeding (4 h) (for 114 days) then acetaminophen (500 mg/kg) (for 99 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood acetaminophen amount |
male |
170.0 days
| 8 |
64.3 |
ug/ml |
9.72 |
27.5 |
high-performance liquid chromatography |
0.0 |
acetaminophen dosing |
240 |
min |
|
4 hr after dosing |
85581 |
1604 |
| Crl:CD(SD) |
plasma acetaminophen level |
standard diet and restricted feeding (4 h) (for 114 days) then acetaminophen (300 mg/kg) (for 99 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood acetaminophen amount |
male |
170.0 days
| 8 |
49.3 |
ug/ml |
5.62 |
15.9 |
high-performance liquid chromatography |
0.0 |
acetaminophen dosing |
240 |
min |
|
4 hr after dosing |
85580 |
1604 |
| Crl:CD(SD) |
liver oxidized glutathione level to liver weight ratio |
standard diet and restricted feeding (4 h) (for 114 days) then acetaminophen (500 mg/kg) (for 99 days) then fasting (for 20 hours) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
liver glutathione amount |
male |
170.0 days
| 8 |
0.14 |
umol/g |
0.0 |
0.01 |
reduced glutathione/oxidized glutathione enzyme recycling assay |
0.0 |
|
|
|
enzyme recycling method |
|
85577 |
1604 |