| Crl:CD(SD) |
food intake weight to body weight ratio |
standard diet and restricted feeding (4 h) then acetaminophen (300 mg/kg) (for 77 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
147.0 days
| 8 |
4.37 |
g/d/100g |
0.23 |
0.66 |
unspecified method |
0.0 |
|
|
|
|
on days 74-77 |
85510 |
1604 |
| Crl:CD(SD) |
body weight |
standard diet then acetaminophen (500 mg/kg) (for 1 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
body mass |
male |
71.0 days
| 8 |
375.0 |
g |
6.36 |
18.0 |
body weighing method |
0.0 |
|
|
|
|
|
85520 |
1604 |
| Crl:CD(SD) |
body weight |
standard diet and restricted feeding (4 h) then acetaminophen (500 mg/kg) (for 1 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
body mass |
male |
71.0 days
| 8 |
287.0 |
g |
5.3 |
15.0 |
body weighing method |
0.0 |
|
|
|
|
|
85523 |
1604 |
| Crl:CD(SD) |
body weight |
standard diet and restricted feeding (4 h) then acetaminophen (300 mg/kg) (for 98 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
body mass |
male |
168.0 days
| 8 |
447.0 |
g |
16.62 |
47.0 |
body weighing method |
0.0 |
|
|
|
|
|
85552 |
1604 |
| Crl:CD(SD) |
food intake rate |
standard diet and restricted feeding (4 h) then acetaminophen (300 mg/kg) (for 98 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
168.0 days
| 8 |
18.3 |
g/d |
1.98 |
5.6 |
unspecified method |
0.0 |
|
|
|
|
|
85486 |
1604 |
| Crl:CD(SD) |
food intake weight to body weight ratio |
standard diet then acetaminophen (300 mg/kg) (for 98 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
168.0 days
| 8 |
4.05 |
g/d/100g |
0.08 |
0.24 |
unspecified method |
0.0 |
|
|
|
|
on days 95-98 |
85513 |
1604 |
| Crl:CD(SD) |
body weight |
standard diet and restricted feeding (4 h) then acetaminophen (300 mg/kg) (for 1 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
body mass |
male |
71.0 days
| 8 |
287.0 |
g |
6.72 |
19.0 |
body weighing method |
0.0 |
|
|
|
|
|
85522 |
1604 |
| Crl:CD(SD) |
body weight |
standard diet then acetaminophen (500 mg/kg) (for 98 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
body mass |
male |
168.0 days
| 8 |
564.0 |
g |
15.2 |
43.0 |
body weighing method |
0.0 |
|
|
|
|
|
85550 |
1604 |
| Crl:CD(SD) |
liver wet weight |
standard diet and restricted feeding (4 h) (for 114 days) then acetaminophen (500 mg/kg) (for 99 days) then fasting (for 20 hours) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
liver mass |
male |
170.0 days
| 8 |
12.8 |
g |
0.22 |
0.61 |
unspecified method |
0.0 |
|
|
|
|
|
85559 |
1604 |
| Crl:CD(SD) |
food intake rate |
standard diet and restricted feeding (4 h) then acetaminophen (300 mg/kg) (for 56 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
126.0 days
| 8 |
22.1 |
g/d |
0.71 |
2.0 |
unspecified method |
0.0 |
|
|
|
|
|
85474 |
1604 |
| Crl:CD(SD) |
food intake weight to body weight ratio |
standard diet and restricted feeding (4 h) then acetaminophen (500 mg/kg) (for 77 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
147.0 days
| 8 |
4.03 |
g/d/100g |
0.29 |
0.81 |
unspecified method |
0.0 |
|
|
|
|
on days 74-77 |
85511 |
1604 |
| Crl:CD(SD) |
body weight |
standard diet then acetaminophen (300 mg/kg) (for 35 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
body mass |
male |
105.0 days
| 8 |
477.0 |
g |
7.42 |
21.0 |
body weighing method |
0.0 |
|
|
|
|
|
85531 |
1604 |
| Crl:CD(SD) |
plasma acetaminophen level area under curve |
standard diet and restricted feeding (4 h) (for 114 days) then acetaminophen (500 mg/kg) (for 99 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood acetaminophen amount |
male |
170.0 days
| 8 |
500.6 |
(ug/ml) x h |
64.42 |
182.2 |
high-performance liquid chromatography |
0.0 |
acetaminophen dosing |
1140 |
min |
4-19 hr dosing |
4-19 hr dosing |
85589 |
1604 |
| Crl:CD(SD) |
food intake rate |
standard diet and restricted feeding (4 h) then acetaminophen (500 mg/kg) (for 35 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
105.0 days
| 8 |
16.7 |
g/d |
0.95 |
2.7 |
unspecified method |
0.0 |
|
|
|
|
|
85469 |
1604 |
| Crl:CD(SD) |
food intake weight to body weight ratio |
standard diet and restricted feeding (4 h) then acetaminophen (300 mg/kg) (for 14 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
84.0 days
| 8 |
6.04 |
g/d/100g |
0.21 |
0.58 |
unspecified method |
0.0 |
|
|
|
|
on days 11-14 |
85492 |
1604 |
| Crl:CD(SD) |
plasma acetaminophen level area under curve |
standard diet then acetaminophen (500 mg/kg) (for 99 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood acetaminophen amount |
male |
170.0 days
| 8 |
893.3 |
(ug/ml) x h |
44.55 |
126.0 |
high-performance liquid chromatography |
0.0 |
acetaminophen dosing |
1140 |
min |
4-19 hr dosing |
4-19 hr dosing |
85587 |
1604 |
| Crl:CD(SD) |
plasma acetaminophen level |
standard diet then acetaminophen (300 mg/kg) (for 99 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood acetaminophen amount |
male |
170.0 days
| 8 |
88.0 |
ug/ml |
3.89 |
11.0 |
high-performance liquid chromatography |
0.0 |
acetaminophen dosing |
240 |
min |
|
4 hr after dosing |
85578 |
1604 |
| Crl:CD(SD) |
food intake rate |
standard diet and restricted feeding (4 h) then acetaminophen (500 mg/kg) (for 98 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
168.0 days
| 8 |
16.6 |
g/d |
0.95 |
2.7 |
unspecified method |
0.0 |
|
|
|
|
|
85487 |
1604 |
| Crl:CD(SD) |
liver wet weight |
standard diet then acetaminophen (500 mg/kg) (for 99 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
liver mass |
male |
170.0 days
| 8 |
20.3 |
g |
0.7 |
1.98 |
unspecified method |
0.0 |
|
|
|
|
liver weight not available |
85556 |
1604 |
| Crl:CD(SD) |
food intake rate |
standard diet then acetaminophen (500 mg/kg) (for 98 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
168.0 days
| 8 |
22.8 |
g/d |
0.71 |
2.0 |
unspecified method |
0.0 |
|
|
|
|
|
85484 |
1604 |
| Crl:CD(SD) |
food intake weight to body weight ratio |
standard diet then acetaminophen (500 mg/kg) (for 35 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
105.0 days
| 8 |
5.12 |
g/d/100g |
0.15 |
0.42 |
unspecified method |
0.0 |
|
|
|
|
on days 32-35 |
85496 |
1604 |
| Crl:CD(SD) |
body weight |
standard diet and restricted feeding (4 h) then acetaminophen (300 mg/kg) (for 14 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
body mass |
male |
84.0 days
| 8 |
333.0 |
g |
8.13 |
23.0 |
body weighing method |
0.0 |
|
|
|
|
|
85528 |
1604 |
| Crl:CD(SD) |
body weight |
standard diet and restricted feeding (4 h) then acetaminophen (300 mg/kg) (for 35 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
body mass |
male |
105.0 days
| 8 |
375.0 |
g |
12.73 |
36.0 |
body weighing method |
0.0 |
|
|
|
|
|
85534 |
1604 |
| Crl:CD(SD) |
body weight |
standard diet and restricted feeding (4 h) then acetaminophen (500 mg/kg) (for 35 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
body mass |
male |
105.0 days
| 8 |
365.0 |
g |
6.36 |
18.0 |
body weighing method |
0.0 |
|
|
|
|
|
85535 |
1604 |
| Crl:CD(SD) |
liver reduced glutathione level to liver weight ratio |
standard diet and restricted feeding (4 h) (for 114 days) then acetaminophen (500 mg/kg) (for 99 days) then fasting (for 20 hours) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
liver glutathione amount |
male |
170.0 days
| 8 |
5.19 |
umol/g |
0.24 |
0.69 |
reduced glutathione/oxidized glutathione enzyme recycling assay |
0.0 |
|
|
|
enzyme recycling method |
|
85571 |
1604 |
| Crl:CD(SD) |
plasma acetaminophen level |
standard diet then acetaminophen (500 mg/kg) (for 99 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood acetaminophen amount |
male |
170.0 days
| 8 |
1.1 |
ug/ml |
0.32 |
0.9 |
high-performance liquid chromatography |
0.0 |
acetaminophen dosing |
1140 |
min |
|
19 hr after dosing |
85583 |
1604 |
| Crl:CD(SD) |
liver reduced glutathione level to liver weight ratio |
standard diet then acetaminophen (300 mg/kg) (for 99 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
liver glutathione amount |
male |
170.0 days
| 8 |
9.16 |
umol/g |
0.18 |
0.5 |
reduced glutathione/oxidized glutathione enzyme recycling assay |
0.0 |
|
|
|
enzyme recycling method |
reduced liver glutathione level to liver weight ratio |
85567 |
1604 |
| Crl:CD(SD) |
body weight |
standard diet then acetaminophen (300 mg/kg) (for 14 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
body mass |
male |
84.0 days
| 8 |
418.0 |
g |
6.72 |
19.0 |
body weighing method |
0.0 |
|
|
|
|
|
85525 |
1604 |
| Crl:CD(SD) |
body weight |
standard diet and restricted feeding (4 h) then acetaminophen (300 mg/kg) (for 77 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
body mass |
male |
147.0 days
| 8 |
432.0 |
g |
17.32 |
49.0 |
body weighing method |
0.0 |
|
|
|
|
|
85546 |
1604 |
| Crl:CD(SD) |
food intake weight to body weight ratio |
standard diet and restricted feeding (4 h) then acetaminophen (300 mg/kg) (for 98 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
168.0 days
| 8 |
3.96 |
g/d/100g |
0.35 |
0.98 |
unspecified method |
0.0 |
|
|
|
|
on days 95-98 |
85516 |
1604 |
| Crl:CD(SD) |
food intake rate |
standard diet and restricted feeding (4 h) then acetaminophen (300 mg/kg) (for 14 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
84.0 days
| 8 |
20.3 |
g/d |
1.06 |
3.0 |
unspecified method |
0.0 |
|
|
|
|
|
85462 |
1604 |
| Crl:CD(SD) |
food intake rate |
standard diet then acetaminophen (300 mg/kg) (for 14 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
84.0 days
| 8 |
24.1 |
g/d |
0.53 |
1.5 |
unspecified method |
0.0 |
|
|
|
|
|
85459 |
1604 |
| Crl:CD(SD) |
food intake rate |
standard diet and restricted feeding (4 h) then acetaminophen (500 mg/kg) (for 14 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
84.0 days
| 8 |
18.8 |
g/d |
0.92 |
2.6 |
unspecified method |
0.0 |
|
|
|
|
|
85463 |
1604 |
| Crl:CD(SD) |
food intake rate |
standard diet then acetaminophen (300 mg/kg) (for 98 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
168.0 days
| 8 |
23.4 |
g/d |
0.42 |
1.2 |
unspecified method |
0.0 |
|
|
|
|
|
85483 |
1604 |
| Crl:CD(SD) |
food intake weight to body weight ratio |
standard diet then acetaminophen (300 mg/kg) (for 14 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
84.0 days
| 8 |
5.74 |
g/d/100g |
0.1 |
0.29 |
unspecified method |
0.0 |
|
|
|
|
on days 11-14 |
85489 |
1604 |
| Crl:CD(SD) |
food intake weight to body weight ratio |
standard diet then acetaminophen (300 mg/kg) (for 35 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
105.0 days
| 8 |
5.2 |
g/d/100g |
0.07 |
0.21 |
unspecified method |
0.0 |
|
|
|
|
on days 32-35 |
85495 |
1604 |
| Crl:CD(SD) |
food intake weight to body weight ratio |
standard diet then acetaminophen (500 mg/kg) (for 56 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
126.0 days
| 8 |
4.53 |
g/d/100g |
0.13 |
0.36 |
unspecified method |
0.0 |
|
|
|
|
on days 53-56 |
85502 |
1604 |
| Crl:CD(SD) |
food intake weight to body weight ratio |
standard diet and restricted feeding (4 h) then acetaminophen (300 mg/kg) (for 56 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
126.0 days
| 8 |
4.38 |
g/d/100g |
0.31 |
0.87 |
unspecified method |
0.0 |
|
|
|
|
on days 53-56 |
85504 |
1604 |
| Crl:CD(SD) |
liver wet weight |
standard diet then acetaminophen (300 mg/kg) (for 99 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
liver mass |
male |
170.0 days
| 8 |
20.1 |
g |
0.47 |
1.33 |
unspecified method |
0.0 |
|
|
|
|
liver weight not available |
85555 |
1604 |
| Crl:CD(SD) |
plasma acetaminophen level area under curve |
standard diet then acetaminophen (300 mg/kg) (for 99 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood acetaminophen amount |
male |
170.0 days
| 8 |
662.2 |
(ug/ml) x h |
28.35 |
80.2 |
high-performance liquid chromatography |
0.0 |
acetaminophen dosing |
1140 |
min |
4-19 hr dosing |
4-19 hr dosing |
85586 |
1604 |
| Crl:CD(SD) |
plasma acetaminophen level |
standard diet and restricted feeding (4 h) (for 114 days) then acetaminophen (500 mg/kg) (for 99 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood acetaminophen amount |
male |
170.0 days
| 8 |
2.4 |
ug/ml |
0.71 |
2.0 |
high-performance liquid chromatography |
0.0 |
acetaminophen dosing |
1140 |
min |
|
19 hr after dosing |
85585 |
1604 |
| Crl:CD(SD) |
plasma acetaminophen level area under curve |
standard diet and restricted feeding (4 h) (for 114 days) then acetaminophen (300 mg/kg) (for 99 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood acetaminophen amount |
male |
170.0 days
| 8 |
373.9 |
(ug/ml) x h |
38.93 |
110.1 |
high-performance liquid chromatography |
0.0 |
acetaminophen dosing |
1140 |
min |
4-19 hr dosing |
4-19 hr dosing |
85588 |
1604 |
| Crl:CD(SD) |
food intake rate |
standard diet then acetaminophen (300 mg/kg) (for 77 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
147.0 days
| 8 |
24.3 |
g/d |
0.32 |
0.9 |
unspecified method |
0.0 |
|
|
|
|
|
85477 |
1604 |
| Crl:CD(SD) |
food intake weight to body weight ratio |
standard diet and restricted feeding (4 h) then acetaminophen (500 mg/kg) (for 35 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
105.0 days
| 8 |
4.9 |
g/d/100g |
0.18 |
0.5 |
unspecified method |
0.0 |
|
|
|
|
on days 32-35 |
85499 |
1604 |
| Crl:CD(SD) |
liver oxidized glutathione level to liver weight ratio |
standard diet then acetaminophen (500 mg/kg) (for 99 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
liver glutathione amount |
male |
170.0 days
| 8 |
0.19 |
umol/g |
0.01 |
0.03 |
reduced glutathione/oxidized glutathione enzyme recycling assay |
0.0 |
|
|
|
enzyme recycling method |
reduced liver glutathione level to liver weight ratio |
85574 |
1604 |
| Crl:CD(SD) |
liver wet weight |
standard diet and restricted feeding (4 h) (for 114 days) then acetaminophen (300 mg/kg) (for 99 days) then fasting (for 20 hours) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
liver mass |
male |
170.0 days
| 8 |
12.2 |
g |
0.77 |
2.17 |
unspecified method |
0.0 |
|
|
|
|
|
85558 |
1604 |
| Crl:CD(SD) |
liver oxidized glutathione level to liver weight ratio |
standard diet and restricted feeding (4 h) (for 114 days) then acetaminophen (300 mg/kg) (for 99 days) then fasting (for 20 hours) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
liver glutathione amount |
male |
170.0 days
| 8 |
0.16 |
umol/g |
0.01 |
0.03 |
reduced glutathione/oxidized glutathione enzyme recycling assay |
0.0 |
|
|
|
enzyme recycling method |
|
85576 |
1604 |
| Crl:CD(SD) |
food intake rate |
standard diet then acetaminophen (500 mg/kg) (for 14 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
84.0 days
| 8 |
24.7 |
g/d |
0.46 |
1.3 |
unspecified method |
0.0 |
|
|
|
|
|
85460 |
1604 |
| Crl:CD(SD) |
food intake rate |
standard diet and restricted feeding (4 h) then acetaminophen (300 mg/kg) (for 35 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
105.0 days
| 8 |
18.2 |
g/d |
1.13 |
3.2 |
unspecified method |
0.0 |
|
|
|
|
|
85468 |
1604 |
| Crl:CD(SD) |
food intake weight to body weight ratio |
standard diet and restricted feeding (4 h) then acetaminophen (300 mg/kg) (for 35 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
105.0 days
| 8 |
5.09 |
g/d/100g |
0.24 |
0.67 |
unspecified method |
0.0 |
|
|
|
|
on days 32-35 |
85498 |
1604 |
| Crl:CD(SD) |
food intake weight to body weight ratio |
standard diet then acetaminophen (300 mg/kg) (for 56 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
126.0 days
| 8 |
4.7 |
g/d/100g |
0.06 |
0.17 |
unspecified method |
0.0 |
|
|
|
|
on days 53-56 |
85501 |
1604 |
| Crl:CD(SD) |
food intake weight to body weight ratio |
standard diet then acetaminophen (300 mg/kg) (for 77 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
147.0 days
| 8 |
4.09 |
g/d/100g |
0.45 |
1.28 |
unspecified method |
0.0 |
|
|
|
|
on days 74-77 |
85507 |
1604 |
| Crl:CD(SD) |
food intake weight to body weight ratio |
standard diet then acetaminophen (500 mg/kg) (for 77 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
147.0 days
| 8 |
4.49 |
g/d/100g |
0.08 |
0.23 |
unspecified method |
0.0 |
|
|
|
|
on days 74-77 |
85508 |
1604 |
| Crl:CD(SD) |
food intake weight to body weight ratio |
standard diet and restricted feeding (4 h) then acetaminophen (500 mg/kg) (for 56 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
126.0 days
| 8 |
4.23 |
g/d/100g |
0.27 |
0.77 |
unspecified method |
0.0 |
|
|
|
|
on days 53-56 |
85505 |
1604 |
| Crl:CD(SD) |
body weight |
standard diet then acetaminophen (300 mg/kg) (for 1 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
body mass |
male |
71.0 days
| 8 |
371.0 |
g |
5.66 |
16.0 |
body weighing method |
0.0 |
|
|
|
|
|
85519 |
1604 |
| Crl:CD(SD) |
body weight |
standard diet and restricted feeding (4 h) then acetaminophen (500 mg/kg) (for 14 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
body mass |
male |
84.0 days
| 8 |
321.0 |
g |
7.78 |
22.0 |
body weighing method |
0.0 |
|
|
|
|
|
85529 |
1604 |
| Crl:CD(SD) |
body weight |
standard diet then acetaminophen (300 mg/kg) (for 56 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
body mass |
male |
126.0 days
| 8 |
522.0 |
g |
8.13 |
23.0 |
body weighing method |
0.0 |
|
|
|
|
|
85537 |
1604 |
| Crl:CD(SD) |
body weight |
standard diet then acetaminophen (500 mg/kg) (for 56 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
body mass |
male |
126.0 days
| 8 |
516.0 |
g |
12.73 |
36.0 |
body weighing method |
0.0 |
|
|
|
|
|
85538 |
1604 |
| Crl:CD(SD) |
body weight |
standard diet and restricted feeding (4 h) then acetaminophen (300 mg/kg) (for 56 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
body mass |
male |
126.0 days
| 8 |
404.0 |
g |
12.37 |
35.0 |
body weighing method |
0.0 |
|
|
|
|
|
85540 |
1604 |
| Crl:CD(SD) |
body weight |
standard diet then acetaminophen (300 mg/kg) (for 77 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
body mass |
male |
147.0 days
| 8 |
557.0 |
g |
8.13 |
23.0 |
body weighing method |
0.0 |
|
|
|
|
|
85543 |
1604 |
| Crl:CD(SD) |
body weight |
standard diet then acetaminophen (300 mg/kg) (for 98 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
body mass |
male |
168.0 days
| 8 |
581.0 |
g |
9.19 |
26.0 |
body weighing method |
0.0 |
|
|
|
|
|
85549 |
1604 |
| Crl:CD(SD) |
food intake rate |
standard diet then acetaminophen (500 mg/kg) (for 77 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
147.0 days
| 8 |
24.5 |
g/d |
0.32 |
0.9 |
unspecified method |
0.0 |
|
|
|
|
|
85478 |
1604 |
| Crl:CD(SD) |
food intake weight to body weight ratio |
standard diet and restricted feeding (4 h) then acetaminophen (500 mg/kg) (for 14 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
84.0 days
| 8 |
6.04 |
g/d/100g |
0.23 |
0.66 |
unspecified method |
0.0 |
|
|
|
|
on days 11-14 |
85493 |
1604 |
| Crl:CD(SD) |
body weight |
standard diet then acetaminophen (500 mg/kg) (for 14 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
body mass |
male |
84.0 days
| 8 |
413.0 |
g |
6.01 |
17.0 |
body weighing method |
0.0 |
|
|
|
|
|
85526 |
1604 |
| Crl:CD(SD) |
plasma acetaminophen level |
standard diet then acetaminophen (500 mg/kg) (for 99 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood acetaminophen amount |
male |
170.0 days
| 8 |
118.1 |
ug/ml |
6.43 |
18.2 |
high-performance liquid chromatography |
0.0 |
acetaminophen dosing |
240 |
min |
|
4 hr after dosing |
85579 |
1604 |
| Crl:CD(SD) |
liver reduced glutathione level to liver weight ratio |
standard diet and restricted feeding (4 h) (for 114 days) then acetaminophen (300 mg/kg) (for 99 days) then fasting (for 20 hours) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
liver glutathione amount |
male |
170.0 days
| 8 |
6.24 |
umol/g |
0.31 |
0.87 |
reduced glutathione/oxidized glutathione enzyme recycling assay |
0.0 |
|
|
|
enzyme recycling method |
|
85570 |
1604 |
| Crl:CD(SD) |
food intake rate |
standard diet then acetaminophen (500 mg/kg) (for 56 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
126.0 days
| 8 |
24.9 |
g/d |
0.85 |
2.4 |
unspecified method |
0.0 |
|
|
|
|
|
85472 |
1604 |
| Crl:CD(SD) |
food intake rate |
standard diet and restricted feeding (4 h) then acetaminophen (500 mg/kg) (for 56 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
126.0 days
| 8 |
18.7 |
g/d |
1.45 |
4.1 |
unspecified method |
0.0 |
|
|
|
|
|
85475 |
1604 |
| Crl:CD(SD) |
body weight |
standard diet and restricted feeding (4 h) then acetaminophen (500 mg/kg) (for 77 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
body mass |
male |
147.0 days
| 8 |
431.0 |
g |
8.49 |
24.0 |
body weighing method |
0.0 |
|
|
|
|
|
85547 |
1604 |
| Crl:CD(SD) |
food intake rate |
standard diet then acetaminophen (500 mg/kg) (for 35 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
105.0 days
| 8 |
25.7 |
g/d |
0.28 |
0.8 |
unspecified method |
0.0 |
|
|
|
|
|
85466 |
1604 |
| Crl:CD(SD) |
food intake rate |
standard diet then acetaminophen (300 mg/kg) (for 35 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
105.0 days
| 8 |
24.5 |
g/d |
0.57 |
1.6 |
unspecified method |
0.0 |
|
|
|
|
|
85465 |
1604 |
| Crl:CD(SD) |
food intake rate |
standard diet then acetaminophen (300 mg/kg) (for 56 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
126.0 days
| 8 |
24.6 |
g/d |
0.21 |
0.6 |
unspecified method |
0.0 |
|
|
|
|
|
85471 |
1604 |
| Crl:CD(SD) |
food intake rate |
standard diet and restricted feeding (4 h) then acetaminophen (300 mg/kg) (for 77 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
147.0 days
| 8 |
17.9 |
g/d |
1.77 |
5.0 |
unspecified method |
0.0 |
|
|
|
|
|
85480 |
1604 |
| Crl:CD(SD) |
body weight |
standard diet then acetaminophen (500 mg/kg) (for 35 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
body mass |
male |
105.0 days
| 8 |
472.0 |
g |
8.49 |
24.0 |
body weighing method |
0.0 |
|
|
|
|
|
85532 |
1604 |
| Crl:CD(SD) |
body weight |
standard diet then acetaminophen (500 mg/kg) (for 77 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
body mass |
male |
147.0 days
| 8 |
549.0 |
g |
12.73 |
36.0 |
body weighing method |
0.0 |
|
|
|
|
|
85544 |
1604 |
| Crl:CD(SD) |
food intake rate |
standard diet and restricted feeding (4 h) then acetaminophen (500 mg/kg) (for 77 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
147.0 days
| 8 |
17.7 |
g/d |
1.31 |
3.7 |
unspecified method |
0.0 |
|
|
|
|
|
85481 |
1604 |
| Crl:CD(SD) |
food intake weight to body weight ratio |
standard diet then acetaminophen (500 mg/kg) (for 14 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
84.0 days
| 8 |
5.68 |
g/d/100g |
0.06 |
0.17 |
unspecified method |
0.0 |
|
|
|
|
on days 11-14 |
85490 |
1604 |
| Crl:CD(SD) |
body weight |
standard diet and restricted feeding (4 h) then acetaminophen (500 mg/kg) (for 56 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
body mass |
male |
126.0 days
| 8 |
400.0 |
g |
7.78 |
22.0 |
body weighing method |
0.0 |
|
|
|
|
|
85541 |
1604 |
| Crl:CD(SD) |
body weight |
standard diet and restricted feeding (4 h) then acetaminophen (500 mg/kg) (for 98 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
body mass |
male |
168.0 days
| 8 |
440.0 |
g |
9.19 |
26.0 |
body weighing method |
0.0 |
|
|
|
|
|
85553 |
1604 |
| Crl:CD(SD) |
plasma acetaminophen level |
standard diet and restricted feeding (4 h) (for 114 days) then acetaminophen (300 mg/kg) (for 99 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood acetaminophen amount |
male |
170.0 days
| 8 |
0.6 |
ug/ml |
0.21 |
0.6 |
high-performance liquid chromatography |
0.0 |
acetaminophen dosing |
1140 |
min |
|
19 hr after dosing |
85584 |
1604 |
| Crl:CD(SD) |
food intake weight to body weight ratio |
standard diet and restricted feeding (4 h) then acetaminophen (500 mg/kg) (for 98 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
168.0 days
| 8 |
4.34 |
g/d/100g |
0.34 |
0.96 |
unspecified method |
0.0 |
|
|
|
|
on days 95-98 |
85517 |
1604 |
| Crl:CD(SD) |
food intake weight to body weight ratio |
standard diet then acetaminophen (500 mg/kg) (for 98 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
eating behavior trait |
male |
168.0 days
| 8 |
4.24 |
g/d/100g |
0.06 |
0.18 |
unspecified method |
0.0 |
|
|
|
|
on days 95-98 |
85514 |
1604 |
| Crl:CD(SD) |
liver reduced glutathione level to liver weight ratio |
standard diet then acetaminophen (500 mg/kg) (for 99 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
liver glutathione amount |
male |
170.0 days
| 8 |
9.07 |
umol/g |
0.25 |
0.72 |
reduced glutathione/oxidized glutathione enzyme recycling assay |
0.0 |
|
|
|
enzyme recycling method |
reduced liver glutathione level to liver weight ratio |
85568 |
1604 |
| Crl:CD(SD) |
plasma acetaminophen level |
standard diet then acetaminophen (300 mg/kg) (for 99 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood acetaminophen amount |
male |
170.0 days
| 8 |
0.3 |
ug/ml |
0.18 |
0.5 |
high-performance liquid chromatography |
0.0 |
acetaminophen dosing |
1140 |
min |
|
19 hr after dosing |
85582 |
1604 |
| Crl:CD(SD) |
plasma acetaminophen level |
standard diet and restricted feeding (4 h) (for 114 days) then acetaminophen (500 mg/kg) (for 99 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood acetaminophen amount |
male |
170.0 days
| 8 |
64.3 |
ug/ml |
9.72 |
27.5 |
high-performance liquid chromatography |
0.0 |
acetaminophen dosing |
240 |
min |
|
4 hr after dosing |
85581 |
1604 |
| Crl:CD(SD) |
plasma acetaminophen level |
standard diet and restricted feeding (4 h) (for 114 days) then acetaminophen (300 mg/kg) (for 99 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
blood acetaminophen amount |
male |
170.0 days
| 8 |
49.3 |
ug/ml |
5.62 |
15.9 |
high-performance liquid chromatography |
0.0 |
acetaminophen dosing |
240 |
min |
|
4 hr after dosing |
85580 |
1604 |
| Crl:CD(SD) |
liver oxidized glutathione level to liver weight ratio |
standard diet then acetaminophen (300 mg/kg) (for 99 days) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
liver glutathione amount |
male |
170.0 days
| 8 |
0.24 |
umol/g |
0.01 |
0.02 |
reduced glutathione/oxidized glutathione enzyme recycling assay |
0.0 |
|
|
|
enzyme recycling method |
reduced liver glutathione level to liver weight ratio |
85573 |
1604 |
| Crl:CD(SD) |
liver oxidized glutathione level to liver weight ratio |
standard diet and restricted feeding (4 h) (for 114 days) then acetaminophen (500 mg/kg) (for 99 days) then fasting (for 20 hours) |
Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. |
liver glutathione amount |
male |
170.0 days
| 8 |
0.14 |
umol/g |
0.0 |
0.01 |
reduced glutathione/oxidized glutathione enzyme recycling assay |
0.0 |
|
|
|
enzyme recycling method |
|
85577 |
1604 |