| SHR/NCrl |
logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70.0 days-84.0 days |
8 |
-7.19 |
null |
0.06 |
0.18 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
Moms and pups used in studies were fed Dyets |
57405 |
522 |
| SHR/NCrl |
logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70.0 days-84.0 days |
10 |
-7.19 |
null |
0.06 |
0.2 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
Moms and pups used in studies were fed Dyets |
57411 |
522 |
| SHR/NCrl |
concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) |
phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70.0 days-84.0 days |
8 |
0.35 |
E-7mole |
0.18 |
0.5 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
Moms and pups used in studies were fed Dyets |
56794 |
522 |
| SHR/NCrl |
logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) |
phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70.0 days-84.0 days |
7 |
-7.27 |
null |
0.09 |
0.24 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks |
55371 |
522 |
| SHR/NCrl |
acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70.0 days-84.0 days |
10 |
74.4 |
% |
4.04 |
12.77 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
Moms and pups used in studies were fed Dyets |
55109 |
522 |
| SHR/NCrl |
acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70.0 days-84.0 days |
10 |
100.0 |
% |
0.0 |
0.0 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
Moms and pups used in studies were fed Dyets |
56843 |
522 |
| SHR/NCrl |
acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70.0 days-84.0 days |
7 |
73.0 |
% |
5.91 |
15.63 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks |
57298 |
522 |
| SHR/NCrl |
acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70.0 days-84.0 days |
10 |
65.1 |
% |
4.5 |
14.22 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks |
57301 |
522 |
| SHR/NCrl |
acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70.0 days-84.0 days |
8 |
72.0 |
% |
2.63 |
7.45 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
Moms and pups used in studies were fed Dyets |
55103 |
522 |
| SHR/NCrl |
acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70.0 days-84.0 days |
10 |
100.0 |
% |
0.0 |
0.0 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
Moms and pups used in studies were fed Dyets |
56849 |
522 |
| SHR/NCrl |
concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) |
phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70.0 days-84.0 days |
10 |
0.78 |
E-7mole |
0.13 |
0.4 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks |
57132 |
522 |
| SHR/NCrl |
logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) |
phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70.0 days-84.0 days |
10 |
-7.19 |
null |
0.1 |
0.3 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks |
55374 |
522 |
| SHR/NCrl |
concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70.0 days-84.0 days |
10 |
0.71 |
E-7mole |
0.1 |
0.31 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
Moms and pups used in studies were fed Dyets |
54597 |
522 |
| SHR/NCrl |
logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) |
phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70.0 days-84.0 days |
10 |
-7.62 |
null |
0.23 |
0.72 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
Moms and pups used in studies were fed Dyets |
55022 |
522 |
| SHR/NCrl |
logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) |
phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70.0 days-84.0 days |
8 |
-7.9 |
null |
0.24 |
0.67 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
Moms and pups used in studies were fed Dyets |
55028 |
522 |
| SHR/NCrl |
concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70.0 days-84.0 days |
8 |
0.69 |
E-7mole |
0.09 |
0.26 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
Moms and pups used in studies were fed Dyets |
54591 |
522 |
| SHR/NCrl |
concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) |
phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70.0 days-84.0 days |
10 |
0.58 |
E-7mole |
0.19 |
0.62 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
Moms and pups used in studies were fed Dyets |
56788 |
522 |
| SHR/NCrl |
concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) |
phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70.0 days-84.0 days |
7 |
0.6 |
E-7mole |
0.1 |
0.27 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks |
57129 |
522 |