Phenominer Database Results (186 results)

 
 
How to display a graph
Strain Phenotype Conditions Study Experiment Name Sex Age # of Animals Formula Value Units SEM SD Method Method Duration Post Insult Time Value Clinical Measurement Notes Experiment Notes Record ID Study ID
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 9 -88.0 beats/min 18.35 55.05 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51712 481
SHR/NCrl urine total protein excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data total urine protein amount male 87.0 days-120.0 days 9 24.02 mg/d 3.75 11.24 automated urine analysis Moms and pups used in studies were fed Teklad 51755 481
SHR/NCrl urine total protein excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data total urine protein amount female 87.0 days-120.0 days 10 19.39 mg/d 3.77 11.91 automated urine analysis Moms and pups used in studies were fed Teklad 51758 481
SHR/NCrl creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data glomerular filtration trait female 87.0 days-120.0 days 5 0.97 ml/min 0.1 0.22 urine creatinine analysis Moms and pups used in studies were fed Dyets 51800 481
SHR/NCrl mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 8 127.98 mmHg 2.2 6.22 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51825 481
SHR/NCrl plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data renin activity male 87.0 days-120.0 days 6 1.23 ng/ml/h 0.27 0.66 radioimmunoassay Moms and pups used in studies were fed Teklad 51838 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 8 -8.33 beats/min 29.02 82.09 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51856 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 1 -16.4 beats/min vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51922 481
SHR/NCrl urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data urine sodium amount female 87.0 days-120.0 days 9 10.76 mEq/d 0.53 1.6 flame atomic emission spectrometry Moms and pups used in studies were fed Dyets 52019 481
SHR/NCrl heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 8 423.68 beats/min 13.94 39.43 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50531 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 6 -30.8 beats/min 7.68 18.82 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50591 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 1 3.22 mmHg vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50604 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 8 -25.11 mmHg 3.07 8.68 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50631 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 6 -15.3 mmHg 6.88 16.84 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50809 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 6 2.79 mmHg 5.37 13.15 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50922 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 1 31.89 mmHg vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50931 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 6 11.69 mmHg 6.31 15.46 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50934 481
SHR/NCrl mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 9 137.12 mmHg 4.62 13.86 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50947 481
SHR/NCrl plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity male 87.0 days-120.0 days 5 6.62 ng/ml/h 1.19 2.66 radioimmunoassay Moms and pups used in studies were fed Teklad 51008 481
SHR/NCrl creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data glomerular filtration trait male 87.0 days-120.0 days 5 0.83 ml/min 0.17 0.38 urine creatinine analysis Moms and pups used in studies were fed Teklad 51057 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 7 -2.86 beats/min 5.12 13.54 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51095 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 1 6.51 mmHg vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51131 481
SHR/NCrl plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount male 87.0 days-120.0 days 5 0.32 mg/dl 0.01 0.01 radioimmunoassay Moms and pups used in studies were fed Dyets 51181 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 9 31.18 mmHg 4.47 13.41 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51192 481
SHR/NCrl heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 7 355.95 beats/min 5.94 15.72 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51252 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 9 24.08 mmHg 4.27 12.8 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51341 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 1 2.2 beats/min vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51372 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 9 -16.02 beats/min 14.65 43.95 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51508 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 8 -42.14 beats/min 19.17 54.23 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51511 481
SHR/NCrl urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data urine sodium amount male 87.0 days-120.0 days 8 1.08 mEq/d 0.16 0.45 flame atomic emission spectrometry Moms and pups used in studies were fed Teklad 51521 481
SHR/NCrl heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 8 328.06 beats/min 5.66 16.02 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51582 481
SHR/NCrl plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data blood creatinine amount female 87.0 days-120.0 days 6 0.26 mg/dl 0.0 0.01 radioimmunoassay Moms and pups used in studies were fed Teklad 51652 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 6 31.47 beats/min 18.3 44.84 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50511 481
SHR/NCrl logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 10 -7.19 null 0.06 0.2 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 57411 522
SHR/NCrl logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 8 -8.58 null 0.14 0.39 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 55487 522
SHR/NCrl logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70.0 days-84.0 days 9 -7.45 null 0.17 0.5 wire myography using a Digi-Med tissue force analysis system with force transducer EC50 value is moles/liter Moms and pups used in studies were fed Dyets 55722 522
SHR/NCrl sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 9 99.44 % 0.44 1.33 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 56196 522
SHR/NCrl sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 10 96.9 % 1.87 5.92 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 56202 522
SHR/NCrl concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 10 0.28 10E-7mol/l 0.18 0.57 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 56268 522
SHR/NCrl acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 8 72.0 % 2.63 7.45 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 55103 522
SHR/NCrl acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 10 74.4 % 4.04 12.77 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 55109 522
SHR/NCrl hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 10 31.9 % 3.1 9.8 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 56723 522
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 4 10.79 beats/min 17.8 35.6 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51723 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 9 -26.04 beats/min 15.48 46.44 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51726 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 6 31.28 mmHg 4.3 10.52 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51776 481
SHR/NCrl mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 7 117.77 mmHg 2.86 7.56 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51828 481
SHR/NCrl urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data urine sodium amount male 87.0 days-120.0 days 8 7.96 mEq/d 0.5 1.4 flame atomic emission spectrometry Moms and pups used in studies were fed Teklad 51887 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 6 -12.28 beats/min 7.95 19.48 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51929 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 1 24.43 mmHg vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51965 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 9 -11.11 beats/min 8.75 26.25 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50618 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 7 -23.04 mmHg 2.62 6.92 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50634 481
SHR/NCrl mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 8 153.09 mmHg 2.46 6.96 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50645 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 6 -14.23 beats/min 4.03 9.87 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50689 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 9 4.57 mmHg 2.78 8.35 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50703 481
SHR/NCrl mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 8 173.36 mmHg 5.88 16.63 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50739 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 6 4.02 mmHg 8.2 20.09 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50783 481
SHR/NCrl heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 6 357.13 beats/min 8.47 20.75 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50883 481
SHR/NCrl mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 4 165.57 mmHg 8.37 16.74 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50944 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 4 29.71 mmHg 9.04 18.07 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50966 481
SHR/NCrl plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity female 87.0 days-120.0 days 6 3.33 ng/ml/h 0.45 1.11 radioimmunoassay Moms and pups used in studies were fed Teklad 51011 481
SHR/NCrl mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 9 145.23 mmHg 3.65 10.96 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51146 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 9 -58.2 beats/min 16.54 49.62 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51226 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 6 -14.73 beats/min 16.5 40.43 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51242 481
SHR/NCrl urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data urine sodium amount male 87.0 days-120.0 days 10 1.46 mEq/d 0.11 0.36 flame atomic emission spectrometry Moms and pups used in studies were fed Dyets 51270 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 9 -35.62 beats/min 11.0 33.01 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51357 481
SHR/NCrl urine albumin excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data urine albumin amount female 87.0 days-120.0 days 10 0.47 mg/d 0.04 0.12 automated urine analysis Moms and pups used in studies were fed Teklad 51474 481
SHR/NCrl urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data urine sodium amount female 87.0 days-120.0 days 9 1.03 mEq/d 0.18 0.54 flame atomic emission spectrometry Moms and pups used in studies were fed Teklad 51524 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 1 -32.2 beats/min vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50357 481
SHR/NCrl heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 9 385.51 beats/min 15.45 46.36 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50479 481
SHR/NCrl maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait female 70.0 days-84.0 days 9 1.76 g/mg 0.11 0.34 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 56986 522
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 9 -12.33 beats/min 17.47 52.4 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51696 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 8 -49.56 beats/min 32.32 91.43 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51699 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 4 -32.18 beats/min 19.16 38.31 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51709 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 1 15.69 mmHg vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51773 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 9 34.22 beats/min 12.04 36.13 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51853 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 1 31.77 mmHg vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51868 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 6 21.1 mmHg 4.61 11.29 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51871 481
SHR/NCrl creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data glomerular filtration trait male 87.0 days-120.0 days 6 1.2 ml/min 0.09 0.22 urine creatinine analysis Moms and pups used in studies were fed Teklad 51949 481
SHR/NCrl creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data glomerular filtration trait female 87.0 days-120.0 days 6 0.78 ml/min 0.07 0.16 urine creatinine analysis Moms and pups used in studies were fed Teklad 51952 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 6 -11.07 beats/min 14.76 36.15 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 52056 481
SHR/NCrl mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 6 159.87 mmHg 7.95 19.47 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 52093 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 1 13.4 beats/min vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50584 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 8 -22.11 beats/min 15.52 43.91 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50621 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 1 24.4 beats/min vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50722 481
SHR/NCrl heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 6 380.26 beats/min 6.27 15.36 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50886 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 1 8.33 mmHg vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50915 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 6 12.15 beats/min 5.65 13.83 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50982 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 9 2.47 mmHg 5.7 17.11 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51025 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 1 15.43 mmHg vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51105 481
SHR/NCrl mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 8 139.16 mmHg 4.78 13.51 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51149 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 9 -16.07 beats/min 16.66 49.99 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51162 481
SHR/NCrl plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount female 87.0 days-120.0 days 7 0.29 mg/dl 0.01 0.02 radioimmunoassay Moms and pups used in studies were fed Dyets 51175 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 1 -22.2 beats/min vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51235 481
SHR/NCrl heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 8 321.19 beats/min 5.4 15.26 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51249 481
SHR/NCrl heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 10 368.99 beats/min 4.04 12.76 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51288 481
SHR/NCrl urine total protein excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data total urine protein amount male 87.0 days-120.0 days 10 30.45 mg/d 6.31 19.96 automated urine analysis Moms and pups used in studies were fed Dyets 51440 481
SHR/NCrl urine total protein excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data total urine protein amount female 87.0 days-120.0 days 9 10.33 mg/d 1.94 5.81 automated urine analysis Moms and pups used in studies were fed Dyets 51443 481
SHR/NCrl creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data glomerular filtration trait female 87.0 days-120.0 days 7 1.08 ml/min 0.08 0.2 urine creatinine analysis Moms and pups used in studies were fed Dyets 51544 481
SHR/NCrl mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 1 140.45 mmHg vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51632 481
SHR/NCrl heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 1 374.2 beats/min vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50325 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 6 -12.88 beats/min 7.63 18.69 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50364 481
SHR/NCrl plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity female 87.0 days-120.0 days 7 10.95 ng/ml/h 1.24 3.28 radioimmunoassay Moms and pups used in studies were fed Dyets 50391 481
SHR/NCrl plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data renin activity male 87.0 days-120.0 days 7 0.83 ng/ml/h 0.23 0.6 radioimmunoassay Moms and pups used in studies were fed Dyets 50464 481
SHR/NCrl percent change in ventilation controlled sodium content diet (0 %) then controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 10 %change=VE during7-9 min hypoxia/control during standard conditions 136.37 % 4.67 14.76 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 17923 381
SHR/NCrl hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 9 51.44 % 3.36 10.09 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 56447 522
SHR/NCrl concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70.0 days-84.0 days 10 0.08 umol/l 0.02 0.07 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 56884 522
SHR/NCrl plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data renin activity female 87.0 days-120.0 days 6 0.65 ng/ml/h 0.25 0.6 radioimmunoassay Moms and pups used in studies were fed Teklad 51841 481
SHR/NCrl urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data urine sodium amount female 87.0 days-120.0 days 10 7.15 mEq/d 0.51 1.6 flame atomic emission spectrometry Moms and pups used in studies were fed Teklad 51890 481
SHR/NCrl mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 6 137.69 mmHg 5.58 13.68 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 52005 481
SHR/NCrl urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data urine sodium amount male 87.0 days-120.0 days 10 13.71 mEq/d 0.45 1.42 flame atomic emission spectrometry Moms and pups used in studies were fed Dyets 52016 481
SHR/NCrl plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data blood creatinine amount female 87.0 days-120.0 days 5 0.29 mg/dl 0.01 0.03 radioimmunoassay Moms and pups used in studies were fed Dyets 52039 481
SHR/NCrl mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 1 136.28 mmHg vascular fluid filled catheter Moms and pups used in studies were fed Teklad 52086 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 6 1.29 mmHg 2.0 4.9 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50607 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 4 10.43 mmHg 7.64 15.28 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50700 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 6 -11.63 beats/min 18.33 44.89 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50725 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 9 41.52 mmHg 2.24 6.72 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50754 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 6 17.34 beats/min 5.18 12.69 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50985 481
SHR/NCrl creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data glomerular filtration trait female 87.0 days-120.0 days 4 0.59 ml/min 0.17 0.33 urine creatinine analysis Moms and pups used in studies were fed Teklad 51060 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 4 23.97 mmHg 6.39 12.79 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51189 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 8 -60.76 beats/min 16.42 46.43 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51207 481
SHR/NCrl heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 8 364.35 beats/min 14.69 41.56 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51285 481
SHR/NCrl plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount male 87.0 days-120.0 days 5 0.28 mg/dl 0.01 0.03 radioimmunoassay Moms and pups used in studies were fed Teklad 51315 481
SHR/NCrl plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount female 87.0 days-120.0 days 5 0.29 mg/dl 0.01 0.02 radioimmunoassay Moms and pups used in studies were fed Teklad 51318 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 8 30.72 mmHg 3.16 8.94 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51429 481
SHR/NCrl creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data glomerular filtration trait male 87.0 days-120.0 days 5 1.42 ml/min 0.18 0.41 urine creatinine analysis Moms and pups used in studies were fed Dyets 51550 481
SHR/NCrl urine albumin excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data urine albumin amount male 87.0 days-120.0 days 10 1.03 mg/d 0.16 0.51 automated urine analysis Moms and pups used in studies were fed Dyets 51566 481
SHR/NCrl heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 8 361.82 beats/min 5.01 14.16 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51585 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 9 2.21 mmHg 3.87 11.6 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51596 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 8 -4.86 mmHg 5.79 16.37 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51599 481
SHR/NCrl mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 6 129.66 mmHg 2.23 5.45 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51635 481
SHR/NCrl plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data blood creatinine amount male 87.0 days-120.0 days 6 0.27 mg/dl 0.01 0.03 radioimmunoassay Moms and pups used in studies were fed Teklad 51649 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 9 13.96 mmHg 1.62 4.85 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50374 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 1 105.2 beats/min vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50423 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 6 12.97 beats/min 16.28 39.87 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50426 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 1 23.0 beats/min vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50508 481
SHR/NCrl percent change in ventilation controlled sodium content diet (0 %) then controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 9 %change=VE during7-9 min hypoxia/control during standard conditions 130.1 % 7.9 23.69 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 17916 381
SHR/NCrl logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 8 -7.19 null 0.06 0.18 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 57405 522
SHR/NCrl logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 10 -7.97 null 0.17 0.54 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 55493 522
SHR/NCrl logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70.0 days-84.0 days 10 -7.22 null 0.11 0.35 wire myography using a Digi-Med tissue force analysis system with force transducer EC50 value is moles/liter Moms and pups used in studies were fed Dyets 55728 522
SHR/NCrl concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 8 0.69 E-7mole 0.09 0.26 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 54591 522
SHR/NCrl concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 8 0.04 10E-7mol/l 0.01 0.03 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 56262 522
SHR/NCrl maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait male 70.0 days-84.0 days 10 1.09 g/mg 0.08 0.24 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 56992 522
SHR/NCrl creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data glomerular filtration trait male 87.0 days-120.0 days 6 1.53 ml/min 0.06 0.16 urine creatinine analysis Moms and pups used in studies were fed Dyets 51806 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 6 19.47 mmHg 4.39 10.76 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51972 481
SHR/NCrl mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 6 156.06 mmHg 6.95 17.02 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 52002 481
SHR/NCrl plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data blood creatinine amount male 87.0 days-120.0 days 6 0.31 mg/dl 0.01 0.02 radioimmunoassay Moms and pups used in studies were fed Dyets 52045 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 1 75.2 beats/min vascular fluid filled catheter Moms and pups used in studies were fed Dyets 52053 481
SHR/NCrl heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 9 356.76 beats/min 13.66 40.98 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50528 481
SHR/NCrl mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 8 140.95 mmHg 2.98 8.43 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50648 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 9 45.88 mmHg 2.54 7.63 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50661 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 4 31.4 mmHg 8.7 17.4 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50658 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 1 -21.2 beats/min vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50682 481
SHR/NCrl mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 10 149.76 mmHg 4.03 12.74 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50742 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 8 27.55 mmHg 4.09 11.58 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50757 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 1 -1.39 mmHg vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50776 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 6 -15.47 mmHg 6.08 14.9 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50806 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 9 44.15 mmHg 3.53 10.6 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50969 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 8 1.24 mmHg 2.67 7.55 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51028 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 8 -6.87 beats/min 2.38 6.72 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51092 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 6 6.71 mmHg 3.2 7.84 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51108 481
SHR/NCrl heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 1 337.8 beats/min vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51118 481
SHR/NCrl heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 6 396.7 beats/min 7.86 19.25 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51121 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 6 -0.23 mmHg 3.97 9.71 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51138 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 4 -13.39 beats/min 9.16 18.32 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51159 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 9 -2.44 beats/min 16.86 50.57 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51204 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 4 -12.98 beats/min 20.48 40.97 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51223 481
SHR/NCrl urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data urine sodium amount female 87.0 days-120.0 days 9 1.32 mEq/d 0.09 0.28 flame atomic emission spectrometry Moms and pups used in studies were fed Dyets 51273 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 8 3.45 mmHg 3.89 11.0 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51344 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 4 -7.68 beats/min 19.7 39.41 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51354 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 6 -37.73 beats/min 10.68 26.16 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51375 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 9 41.75 mmHg 2.35 7.05 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51426 481
SHR/NCrl urine albumin excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data urine albumin amount male 87.0 days-120.0 days 9 0.75 mg/d 0.12 0.36 automated urine analysis Moms and pups used in studies were fed Teklad 51471 481
SHR/NCrl urine albumin excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data urine albumin amount female 87.0 days-120.0 days 9 0.29 mg/d 0.05 0.16 automated urine analysis Moms and pups used in studies were fed Dyets 51569 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 1 21.07 mmHg vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51661 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 6 26.33 mmHg 3.02 7.4 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51668 481
SHR/NCrl heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 6 358.8 beats/min 16.08 39.38 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50332 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 4 17.21 mmHg 4.74 9.48 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50371 481
SHR/NCrl plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity male 87.0 days-120.0 days 8 9.13 ng/ml/h 0.66 1.87 radioimmunoassay Moms and pups used in studies were fed Dyets 50396 481
SHR/NCrl plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data renin activity female 87.0 days-120.0 days 7 0.9 ng/ml/h 0.26 0.68 radioimmunoassay Moms and pups used in studies were fed Dyets 50459 481
SHR/NCrl heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 4 349.08 beats/min 20.02 40.03 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50476 481
SHR/NCrl concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 10 0.71 E-7mole 0.1 0.31 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 54597 522
SHR/NCrl hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 8 8.25 % 2.75 7.78 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 54851 522
SHR/NCrl hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 10 6.4 % 3.45 10.9 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 54857 522
SHR/NCrl hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 8 45.63 % 1.58 4.47 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 56441 522
SHR/NCrl hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 8 26.75 % 3.36 9.5 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 56717 522
SHR/NCrl concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70.0 days-84.0 days 9 0.07 umol/l 0.03 0.08 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 56878 522