Phenominer Database Results (210 results)

 
 
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Strain Phenotype Conditions Study Experiment Name Sex Age # of Animals Formula Value Units SEM SD Method Method Duration Post Insult Time Value Clinical Measurement Notes Experiment Notes Record ID Study ID
SHR/NCrl mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 15 147.31 mmHg 5.31 20.56 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 14327 381
SHR/NCrl percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 20 %change=VE during 2-3 min hypoxia/control during standard conditions 156.99 % 8.63 38.59 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 13674 381
SHR/NCrl percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 9 %change=VE during 2-3 min hypoxia/control during standard conditions 152.97 % 9.67 29.01 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 14034 381
SHR/NCrl percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 10 %change=VE during 2-3 min hypoxia/control during standard conditions 158.25 % 7.19 22.73 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 14041 381
SHR/NCrl absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 10 -0.52 degrees C 0.3 0.95 digital rectal thermometry Moms and pups used in studies were fed Dyets 19583 381
SHR/NCrl percent change in ventilation controlled sodium content diet (0 %) then controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 10 %change=VE during7-9 min hypoxia/control during standard conditions 136.37 % 4.67 14.76 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 17923 381
SHR/NCrl absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 6 -54.34 mmHg 3.56 8.72 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 17938 381
SHR/NCrl minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 9 41.32 ml/min 4.91 14.72 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 18070 381
SHR/NCrl heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 4 366.99 beats/min 23.28 46.55 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 18111 381
SHR/NCrl blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 6 7.53 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17040 381
SHR/NCrl serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77.0 days-91.0 days 20 327.95 U/l 16.2 72.45 standard blood chemistry panel Moms and pups used in studies were fed Teklad 36373 401
SHR/NCrl serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77.0 days-91.0 days 20 6.14 g/dl 0.05 0.25 standard blood chemistry panel Moms and pups used in studies were fed Teklad 36956 401
SHR/NCrl serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77.0 days-91.0 days 17 5.94 g/dl 0.06 0.24 standard blood chemistry panel Moms and pups used in studies were fed Teklad 36959 401
SHR/NCrl heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 7 402.69 beats/min 19.15 50.67 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 17495 381
SHR/NCrl body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 10 37.36 degrees C 0.12 0.39 digital rectal thermometry Moms and pups used in studies were fed Dyets 18239 381
SHR/NCrl respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 20 161.36 breaths/min 6.82 30.5 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 18259 381
SHR/NCrl absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 18 -0.93 degrees C 0.18 0.76 digital rectal thermometry Moms and pups used in studies were fed Teklad 20306 381
SHR/NCrl partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 6 50.35 mmHg 1.64 4.02 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 20467 381
SHR/NCrl absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 6 0.08 null 0.01 0.04 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 20541 381
SHR/NCrl heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49.0 days-63.0 days 9 27.29 % 4.54 13.61 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 49692 461
SHR/NCrl left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 13 111.5 mmHg 4.44 16.0 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 49885 461
SHR/NCrl serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77.0 days-91.0 days 20 16.1 mmol/l 0.61 2.71 standard blood chemistry panel Moms and pups used in studies were fed Teklad 42056 401
SHR/NCrl red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77.0 days-91.0 days 18 11.18 x 10E6 cells/ul 0.15 0.63 automated blood cell counting method Moms and pups used in studies were fed Teklad 39231 401
SHR/NCrl serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77.0 days-91.0 days 20 141.75 mmol/l 0.58 2.57 standard blood chemistry panel Moms and pups used in studies were fed Teklad 39382 401
SHR/NCrl blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity female 77.0 days-91.0 days 15 0.25 x 1000 cells/ul 0.06 0.22 automated blood cell counting method Moms and pups used in studies were fed Teklad 39671 401
SHR/NCrl percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 20 147.52 % 6.83 30.56 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 54314 381
SHR/NCrl blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77.0 days-91.0 days 15 0.8 x 1000 cells/ul 0.14 0.55 automated blood cell counting method Moms and pups used in studies were fed Teklad 43221 401
SHR/NCrl body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass female 77.0 days-91.0 days 25 153.6 g 1.8 9.2 whole body digital scale Moms and pups used in studies were fed Teklad 59059 526
SHR/NCrl serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77.0 days-91.0 days 20 22.5 mg/dl 0.67 2.98 standard blood chemistry panel Moms and pups used in studies were fed Teklad 40822 401
SHR/NCrl total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77.0 days-91.0 days 18 4.84 x 1000 cells/ul 0.41 1.72 automated blood cell counting method Moms and pups used in studies were fed Teklad 40920 401
SHR/NCrl calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 22 0.13 mmHg x min x kg x ml-1 0.01 0.03 fluid-filled catheter with pressure transducer in isolated perfused lung Moms and pups used in studies were fed Teklad 59541 526
SHR/NCrl plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77.0 days-91.0 days 20 24.0 mmol/l 0.7 3.13 standard blood chemistry panel Moms and pups used in studies were fed Teklad 38255 401
SHR/NCrl plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77.0 days-91.0 days 17 22.88 mmol/l 1.17 4.82 standard blood chemistry panel Moms and pups used in studies were fed Teklad 38258 401
SHR/NCrl serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount male 77.0 days-91.0 days 20 156.05 mg/dl 4.51 20.15 standard blood chemistry panel Moms and pups used in studies were fed Teklad 38524 401
SHR/NCrl serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount female 77.0 days-91.0 days 17 151.35 mg/dl 6.49 26.74 standard blood chemistry panel Moms and pups used in studies were fed Teklad 38527 401
SHR/NCrl percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 9 post-ischemic value/pre-ischemic value x 100% 32.63 % 4.46 13.38 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48521 461
SHR/NCrl methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 20 13.31 ml/min/kg 0.75 3.33 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 57794 526
SHR/NCrl body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 20 37.45 degrees C 0.13 0.58 digital rectal thermometry Moms and pups used in studies were fed Teklad 16566 381
SHR/NCrl methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 11 0.37 null 0.04 0.13 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 58107 526
SHR/NCrl heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49.0 days-63.0 days 10 6.65 g/kg 0.23 0.74 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 45622 461
SHR/NCrl heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49.0 days-63.0 days 15 8.01 IU/g 0.91 3.52 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 45707 461
SHR/NCrl arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49.0 days-63.0 days 13 8.75 ml/min/g 1.4 5.05 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 44715 461
SHR/NCrl percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49.0 days-63.0 days 10 post-ischemic value/pre-ischemic value x 100% 58.26 % 4.16 13.17 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 47071 461
SHR/NCrl respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 9 139.86 breaths/min 1.92 5.76 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 15374 381
SHR/NCrl mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 6 129.72 mmHg 6.02 14.74 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 14664 381
SHR/NCrl tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 10 0.36 ml 0.03 0.09 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 13654 381
SHR/NCrl absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 6 0.05 null 0.01 0.01 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 19776 381
SHR/NCrl percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 18 106.96 % 3.84 16.29 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 53871 381
SHR/NCrl percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 18 98.36 % 5.58 23.67 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 53972 381
SHR/NCrl absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 9 -0.93 degrees C 0.24 0.73 digital rectal thermometry Moms and pups used in studies were fed Dyets 19576 381
SHR/NCrl absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 6 -6.09 mmHg 0.99 2.43 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 19625 381
SHR/NCrl absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 11 -8.56 mmHg 1.18 3.91 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 19629 381
SHR/NCrl blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 7 7.53 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17608 381
SHR/NCrl heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 6 409.01 beats/min 5.21 12.75 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 18104 381
SHR/NCrl serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77.0 days-91.0 days 17 77.35 mg/dl 1.49 6.15 standard blood chemistry panel Moms and pups used in studies were fed Teklad 37094 401
SHR/NCrl body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 9 37.26 degrees C 0.12 0.37 digital rectal thermometry Moms and pups used in studies were fed Dyets 18232 381
SHR/NCrl respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 18 143.17 breaths/min 5.72 24.28 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 18262 381
SHR/NCrl minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 20 58.79 ml/min 3.95 17.65 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 20202 381
SHR/NCrl time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 16 1059.06 s 51.85 207.41 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 50224 461
SHR/NCrl mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77.0 days-91.0 days 18 53.99 fl 0.35 1.5 automated blood cell counting method Moms and pups used in studies were fed Teklad 38739 401
SHR/NCrl serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77.0 days-91.0 days 20 4.04 g/dl 0.03 0.15 standard blood chemistry panel Moms and pups used in studies were fed Teklad 42227 401
SHR/NCrl serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount female 77.0 days-91.0 days 17 3.96 g/dl 0.03 0.14 standard blood chemistry panel Moms and pups used in studies were fed Teklad 42230 401
SHR/NCrl serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount female 77.0 days-91.0 days 17 108.41 mmol/l 0.67 2.76 standard blood chemistry panel Moms and pups used in studies were fed Teklad 39114 401
SHR/NCrl red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77.0 days-91.0 days 15 10.55 x 10E6 cells/ul 0.16 0.6 automated blood cell counting method Moms and pups used in studies were fed Teklad 39234 401
SHR/NCrl mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77.0 days-91.0 days 18 17.36 pg 0.08 0.32 automated blood cell counting method Moms and pups used in studies were fed Teklad 42539 401
SHR/NCrl serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77.0 days-91.0 days 20 126.3 U/l 6.45 28.83 standard blood chemistry panel Moms and pups used in studies were fed Teklad 42764 401
SHR/NCrl plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77.0 days-91.0 days 17 0.27 mg/dl 0.02 0.07 automated plasma creatinine analysis Moms and pups used in studies were fed Teklad 39573 401
SHR/NCrl percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 9 152.66 % 6.76 20.29 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 54559 381
SHR/NCrl serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77.0 days-91.0 days 20 2.1 g/dl 0.03 0.15 standard blood chemistry panel replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40544 401
SHR/NCrl serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77.0 days-91.0 days 17 23.29 mg/dl 0.83 3.41 standard blood chemistry panel Moms and pups used in studies were fed Teklad 40825 401
SHR/NCrl lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass female 77.0 days-91.0 days 24 1.44 g/kg 0.05 0.23 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 59654 526
SHR/NCrl blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77.0 days-91.0 days 18 19.41 g/dl 0.23 0.99 automated blood cell counting method Moms and pups used in studies were fed Teklad 37962 401
SHR/NCrl serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77.0 days-91.0 days 19 4.99 mmol/l 0.12 0.54 standard blood chemistry panel Moms and pups used in studies were fed Teklad 38060 401
SHR/NCrl blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77.0 days-91.0 days 15 0.04 x 1000 cells/ul 0.01 0.05 automated blood cell counting method Moms and pups used in studies were fed Teklad 41644 401
SHR/NCrl left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 12 128.51 mmHg 4.91 17.01 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48621 461
SHR/NCrl percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 13 post-ischemic value/pre-ischemic value x 100% 75.69 % 11.37 40.99 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48753 461
SHR/NCrl methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 20 10.18 ml/min/kg 0.55 2.46 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 57592 526
SHR/NCrl partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 5 27.91 mmHg 0.96 2.14 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 16457 381
SHR/NCrl body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 18 37.27 degrees C 0.12 0.49 digital rectal thermometry Moms and pups used in studies were fed Teklad 16569 381
SHR/NCrl fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77.0 days-91.0 days 22 0.05 mmHg-1 0.0 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung Moms and pups used in studies were fed Teklad 58483 526
SHR/NCrl left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 9 140.97 mmHg 6.4 19.2 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 45723 461
SHR/NCrl arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49.0 days-63.0 days 14 9.67 ml/min/g 0.78 2.94 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 46650 461
SHR/NCrl percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49.0 days-63.0 days 14 post-ischemic value/pre-ischemic value x 100% 47.62 % 9.16 34.26 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 47074 461
SHR/NCrl heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 12 200.73 beats/min 27.04 93.68 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 45145 461
SHR/NCrl percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 16 post-ischemic value/pre-ischemic value x 100% 62.41 % 11.33 45.31 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48292 461
SHR/NCrl tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 9 0.25 ml 0.03 0.08 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 14902 381
SHR/NCrl tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 10 0.31 ml 0.02 0.06 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 14909 381
SHR/NCrl partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount female 82.0 days-99.0 days 11 27.88 mmHg 0.63 2.1 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 17237 381
SHR/NCrl tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 20 0.41 ml 0.02 0.08 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 13917 381
SHR/NCrl tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 18 0.33 ml 0.02 0.06 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 13920 381
SHR/NCrl percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 20 106.54 % 3.28 14.65 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 53873 381
SHR/NCrl heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 15 427.79 beats/min 11.17 43.27 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 17500 381
SHR/NCrl minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 18 43.57 ml/min 2.34 9.93 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 20205 381
SHR/NCrl time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49.0 days-63.0 days 10 630.9 s 45.31 143.28 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 49293 461
SHR/NCrl time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49.0 days-63.0 days 16 562.96 s 69.18 276.72 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 49296 461
SHR/NCrl heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49.0 days-63.0 days 15 23.17 % 3.42 13.24 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 49695 461
SHR/NCrl heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49.0 days-63.0 days 10 63.0 mmHg 3.24 10.24 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 49991 461
SHR/NCrl time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 10 987.15 s 84.11 265.98 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 50221 461
SHR/NCrl mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77.0 days-91.0 days 15 16.76 pg 0.08 0.31 automated blood cell counting method Moms and pups used in studies were fed Teklad 42542 401
SHR/NCrl plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77.0 days-91.0 days 20 0.33 mg/dl 0.02 0.07 automated plasma creatinine analysis Moms and pups used in studies were fed Teklad 39570 401
SHR/NCrl blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77.0 days-91.0 days 18 0.37 x 1000 cells/ul 0.04 0.16 automated blood cell counting method Moms and pups used in studies were fed Teklad 39668 401
SHR/NCrl percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 9 85.37 % 3.54 10.61 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 54547 381
SHR/NCrl percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 10 91.27 % 2.44 7.73 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 54553 381
SHR/NCrl dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77.0 days-91.0 days 14 1.42 mg/kg 0.26 0.99 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 58903 526
SHR/NCrl percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 9 159.18 % 10.25 30.75 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 53728 381
SHR/NCrl percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 10 148.83 % 5.57 17.63 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 53734 381
SHR/NCrl percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 18 146.77 % 6.75 28.64 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 53739 381
SHR/NCrl body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass male 77.0 days-91.0 days 25 227.4 g 2.7 13.4 whole body digital scale Moms and pups used in studies were fed Teklad 59056 526
SHR/NCrl serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount female 77.0 days-91.0 days 17 1.98 g/dl 0.03 0.14 standard blood chemistry panel replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40547 401
SHR/NCrl hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity female 77.0 days-91.0 days 14 54.6 % 0.83 3.09 microhematocrit tube assay with visual assessment Moms and pups used in studies were fed Teklad 59254 526
SHR/NCrl serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77.0 days-91.0 days 20 7.8 mg/dl 0.14 0.64 standard blood chemistry panel Moms and pups used in studies were fed Teklad 37588 401
SHR/NCrl serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount female 77.0 days-91.0 days 16 4.69 mmol/l 0.14 0.56 standard blood chemistry panel Moms and pups used in studies were fed Teklad 38063 401
SHR/NCrl blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77.0 days-91.0 days 18 3.5 x 1000 cells/ul 0.34 1.42 automated blood cell counting method Moms and pups used in studies were fed Teklad 41497 401
SHR/NCrl heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49.0 days-63.0 days 17 0.97 g 0.02 0.1 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 45402 461
SHR/NCrl heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 10 257.93 beats/min 12.49 39.49 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 47576 461
SHR/NCrl heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 16 253.98 beats/min 15.59 62.35 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 47579 461
SHR/NCrl percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 12 post-ischemic value/pre-ischemic value x 100% 38.2 % 6.22 21.56 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48524 461
SHR/NCrl percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 9 post-ischemic value/pre-ischemic value x 100% 73.89 % 3.8 11.39 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48750 461
SHR/NCrl FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 10 44.72 ml/min/kg 8.86 28.03 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 57996 526
SHR/NCrl methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 10 0.48 null 0.1 0.33 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 58110 526
SHR/NCrl heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49.0 days-63.0 days 10 8.72 IU/g 0.86 2.72 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 45704 461
SHR/NCrl left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 10 57.84 mmHg 3.28 10.37 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 46411 461
SHR/NCrl respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 20 167.82 breaths/min 5.97 26.68 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 14788 381
SHR/NCrl tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 9 0.28 ml 0.03 0.08 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 13647 381
SHR/NCrl percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 18 %change=VE during 2-3 min hypoxia/control during standard conditions 152.81 % 6.34 26.89 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 13677 381
SHR/NCrl absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 11 0.08 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 19781 381
SHR/NCrl minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 9 34.92 ml/min 3.87 11.61 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 20702 381
SHR/NCrl minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 10 45.35 ml/min 2.66 8.43 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 20709 381
SHR/NCrl percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 20 89.15 % 3.07 13.75 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 53974 381
SHR/NCrl partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 7 55.37 mmHg 2.15 5.69 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 19552 381
SHR/NCrl blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 5 7.51 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17615 381
SHR/NCrl percent change in ventilation controlled sodium content diet (0 %) then controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 9 %change=VE during7-9 min hypoxia/control during standard conditions 130.1 % 7.9 23.69 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 17916 381
SHR/NCrl absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 4 -50.94 mmHg 3.02 6.05 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 17945 381
SHR/NCrl blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 11 7.55 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17045 381
SHR/NCrl serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77.0 days-91.0 days 17 198.0 U/l 5.4 22.28 standard blood chemistry panel Moms and pups used in studies were fed Teklad 36376 401
SHR/NCrl serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77.0 days-91.0 days 20 55.15 mg/dl 1.39 6.21 standard blood chemistry panel Moms and pups used in studies were fed Teklad 37091 401
SHR/NCrl minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 18 47.39 ml/min 2.53 10.75 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 18659 381
SHR/NCrl serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77.0 days-91.0 days 20 9.14 mg/dl 0.06 0.28 standard blood chemistry panel Moms and pups used in studies were fed Teklad 36618 401
SHR/NCrl absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 6 -41.72 mmHg 2.11 5.18 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 19455 381
SHR/NCrl left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 10 100.08 mmHg 4.32 13.67 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 49882 461
SHR/NCrl mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77.0 days-91.0 days 15 52.17 fl 0.2 0.78 automated blood cell counting method Moms and pups used in studies were fed Teklad 38742 401
SHR/NCrl serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77.0 days-91.0 days 17 15.94 mmol/l 1.06 4.37 standard blood chemistry panel Moms and pups used in studies were fed Teklad 42059 401
SHR/NCrl hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77.0 days-91.0 days 18 60.33 % 0.72 3.06 automated blood cell counting method Moms and pups used in studies were fed Teklad 38985 401
SHR/NCrl serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount male 77.0 days-91.0 days 20 106.9 mmol/l 0.35 1.59 standard blood chemistry panel Moms and pups used in studies were fed Teklad 39111 401
SHR/NCrl serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77.0 days-91.0 days 16 166.44 U/l 9.55 38.2 standard blood chemistry panel Moms and pups used in studies were fed Teklad 42767 401
SHR/NCrl percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 18 143.92 % 5.23 22.19 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 54312 381
SHR/NCrl percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 9 96.69 % 3.08 9.24 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 53547 381
SHR/NCrl serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77.0 days-91.0 days 20 60.8 U/l 3.32 14.86 standard blood chemistry panel Moms and pups used in studies were fed Teklad 40708 401
SHR/NCrl serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77.0 days-91.0 days 17 7.25 mg/dl 0.28 1.14 standard blood chemistry panel Moms and pups used in studies were fed Teklad 37591 401
SHR/NCrl calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 19 0.12 mmHg x min x kg x ml-1 0.0 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung Moms and pups used in studies were fed Teklad 59544 526
SHR/NCrl lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass male 77.0 days-91.0 days 25 1.19 g/kg 0.02 0.12 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 59651 526
SHR/NCrl serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77.0 days-91.0 days 20 0.19 mg/dl 0.02 0.09 standard blood chemistry panel Moms and pups used in studies were fed Teklad 41862 401
SHR/NCrl serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77.0 days-91.0 days 17 0.19 mg/dl 0.03 0.11 standard blood chemistry panel Moms and pups used in studies were fed Teklad 41865 401
SHR/NCrl left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 9 135.07 mmHg 6.34 19.02 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48618 461
SHR/NCrl fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77.0 days-91.0 days 19 0.05 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung Moms and pups used in studies were fed Teklad 58486 526
SHR/NCrl heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass female 77.0 days-91.0 days 24 0.32 null 0.01 0.06 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 58730 526
SHR/NCrl arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49.0 days-63.0 days 10 5.44 ml/min/g 0.5 1.58 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 44712 461
SHR/NCrl left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 10 5.93 mmHg 0.23 0.73 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 47191 461
SHR/NCrl left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 15 5.62 mmHg 0.15 0.59 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 47194 461
SHR/NCrl heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 9 243.51 beats/min 26.83 80.49 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 45142 461
SHR/NCrl heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49.0 days-63.0 days 10 0.4 IU/g 0.1 0.32 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 47448 461
SHR/NCrl heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49.0 days-63.0 days 17 0.31 IU/g 0.05 0.2 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 47452 461
SHR/NCrl left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 10 42.24 mmHg 6.2 19.62 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 45264 461
SHR/NCrl respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 10 149.95 breaths/min 6.09 19.27 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 15381 381
SHR/NCrl mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 4 150.49 mmHg 9.72 19.45 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 14671 381
SHR/NCrl tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 20 0.35 ml 0.02 0.08 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 15227 381
SHR/NCrl tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 18 0.3 ml 0.01 0.06 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 15230 381
SHR/NCrl respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 18 144.07 breaths/min 4.5 19.08 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 14791 381
SHR/NCrl mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 7 157.62 mmHg 8.16 21.6 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 14322 381
SHR/NCrl partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount male 82.0 days-99.0 days 6 28.66 mmHg 0.69 1.69 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 17233 381
SHR/NCrl percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 20 152.74 % 5.48 24.52 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 53741 381
SHR/NCrl partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 5 54.23 mmHg 1.9 4.25 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 19559 381
SHR/NCrl respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 9 146.51 breaths/min 8.7 26.09 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 17686 381
SHR/NCrl respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 10 148.67 breaths/min 5.94 18.77 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 17693 381
SHR/NCrl absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 6 -8.2 mmHg 1.55 3.8 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 17710 381
SHR/NCrl absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 4 -10.59 mmHg 0.49 0.99 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 17717 381
SHR/NCrl minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 10 53.23 ml/min 4.41 13.96 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 18077 381
SHR/NCrl minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 20 66.93 ml/min 4.04 18.05 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 18656 381
SHR/NCrl serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount female 77.0 days-91.0 days 17 9.03 mg/dl 0.1 0.4 standard blood chemistry panel Moms and pups used in studies were fed Teklad 36621 401
SHR/NCrl absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 11 -44.75 mmHg 2.02 6.69 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 19460 381
SHR/NCrl absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 20 -0.16 degrees C 0.21 0.92 digital rectal thermometry Moms and pups used in studies were fed Teklad 20303 381
SHR/NCrl partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 11 53.93 mmHg 1.69 5.61 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 20472 381
SHR/NCrl absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 4 0.07 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 20548 381
SHR/NCrl body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass female 49.0 days-63.0 days 10 136.9 g 3.5 11.0 whole body digital scale Moms and pups used in studies were fed Teklad 49524 461
SHR/NCrl heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49.0 days-63.0 days 15 58.27 mmHg 3.26 12.63 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 49994 461
SHR/NCrl hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77.0 days-91.0 days 15 55.04 % 0.89 3.43 automated blood cell counting method Moms and pups used in studies were fed Teklad 38988 401
SHR/NCrl serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount female 77.0 days-91.0 days 17 142.41 mmol/l 0.55 2.27 standard blood chemistry panel Moms and pups used in studies were fed Teklad 39385 401
SHR/NCrl mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77.0 days-91.0 days 18 32.17 g/dl 0.12 0.51 automated blood cell counting method Moms and pups used in studies were fed Teklad 39771 401
SHR/NCrl mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77.0 days-91.0 days 15 32.11 g/dl 0.13 0.52 automated blood cell counting method Moms and pups used in studies were fed Teklad 39774 401
SHR/NCrl blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77.0 days-91.0 days 18 0.96 x 1000 cells/ul 0.12 0.53 automated blood cell counting method Moms and pups used in studies were fed Teklad 43218 401
SHR/NCrl percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 10 150.45 % 6.35 20.09 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 54565 381
SHR/NCrl percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 10 106.61 % 3.55 11.23 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 53553 381
SHR/NCrl dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77.0 days-91.0 days 15 1.68 mg/kg 0.23 0.91 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 58900 526
SHR/NCrl serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77.0 days-91.0 days 16 69.13 U/l 3.45 13.78 standard blood chemistry panel Moms and pups used in studies were fed Teklad 40711 401
SHR/NCrl hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77.0 days-91.0 days 17 60.55 % 0.73 3.01 microhematocrit tube assay with visual assessment Moms and pups used in studies were fed Teklad 59251 526
SHR/NCrl total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77.0 days-91.0 days 15 4.07 x 1000 cells/ul 0.51 1.97 automated blood cell counting method Moms and pups used in studies were fed Teklad 40923 401
SHR/NCrl blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77.0 days-91.0 days 15 17.69 g/dl 0.27 1.06 automated blood cell counting method Moms and pups used in studies were fed Teklad 37965 401
SHR/NCrl blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77.0 days-91.0 days 15 2.97 x 1000 cells/ul 0.39 1.51 automated blood cell counting method Moms and pups used in studies were fed Teklad 41500 401
SHR/NCrl blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77.0 days-91.0 days 18 0.02 x 1000 cells/ul 0.01 0.03 automated blood cell counting method Moms and pups used in studies were fed Teklad 41641 401
SHR/NCrl heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49.0 days-63.0 days 10 1.28 g 0.04 0.11 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 45399 461
SHR/NCrl methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 18 12.32 ml/min/kg 0.97 4.11 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 57595 526
SHR/NCrl methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 18 16.03 ml/min/kg 1.14 4.85 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 57797 526
SHR/NCrl partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 7 27.41 mmHg 1.05 2.76 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 16450 381
SHR/NCrl FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 11 36.66 ml/min/kg 2.94 9.76 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 57993 526
SHR/NCrl heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass male 77.0 days-91.0 days 25 0.37 null 0.01 0.07 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 58727 526
SHR/NCrl left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 12 139.01 mmHg 6.08 21.06 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 45726 461
SHR/NCrl arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49.0 days-63.0 days 10 9.31 ml/min/g 0.45 1.43 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 46647 461
SHR/NCrl percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 10 post-ischemic value/pre-ischemic value x 100% 85.73 % 12.53 39.64 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48289 461
SHR/NCrl left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 13 55.05 mmHg 2.35 8.47 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 46414 461
SHR/NCrl left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 13 56.32 mmHg 5.51 19.88 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 45267 461