GK/Jpe |
logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) |
control condition |
Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. |
vasodilation trait |
male |
540 days
| 7 |
-5.87 |
null |
0.07 |
0.19 |
tissue force analysis utilizing a force transducer |
0.0 |
0 |
|
109095 |
3108 |
GK/Jpe |
logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) |
controlled cholesterol content diet (1.25 %) (for 90 days) and controlled cocoa butter content diet (7.5 %) (for 90 days) |
Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. |
vasodilation trait |
male |
540 days
| 7 |
-6.16 |
null |
0.07 |
0.19 |
tissue force analysis utilizing a force transducer |
0.0 |
0 |
|
109096 |
3108 |
GK/Jpe |
serum triglyceride level |
fasting (for 15 hours) |
Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. |
blood triglyceride amount |
male |
540 days
| 7 |
160.18 |
mg/dl |
69.03 |
182.63 |
colorimetry |
0.0 |
0 |
|
110881 |
3193 |
GK/Jpe |
serum triglyceride level |
controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and soybean oil (2 ml/kg) (for 90 days) then fasting (for 15 hours) |
Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. |
blood triglyceride amount |
male |
540 days
| 7 |
196.46 |
mg/dl |
37.17 |
98.34 |
colorimetry |
0.0 |
0 |
|
110883 |
3193 |
GK/Jpe |
serum aspartate aminotransferase activity level |
controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and lipoic acid (50 mg/kg) (for 90 days) then fasting (for 15 hours) |
Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. |
blood aspartate transaminase amount |
male |
540 days
| 7 |
151.0 |
U/l |
8.7 |
23.02 |
blood enzyme activity assay |
0.0 |
0 |
|
110899 |
3193 |
GK/Jpe |
serum alanine aminotransferase activity level |
controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and soybean oil (2 ml/kg) (for 90 days) then fasting (for 15 hours) |
Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. |
blood alanine transaminase amount |
male |
540 days
| 7 |
27.0 |
U/l |
2.0 |
5.29 |
blood enzyme activity assay |
0.0 |
0 |
|
110903 |
3193 |
GK/Jpe |
plasma malondialdehyde level |
controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and lipoic acid (50 mg/kg) (for 90 days) then fasting (for 15 hours) |
Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. |
blood malondialdehyde amount |
male |
540 days
| 7 |
1.11 |
umol/l |
0.1 |
0.26 |
high-performance liquid chromatography |
0.0 |
0 |
|
110925 |
3193 |
GK/Jpe |
body weight gain |
controlled cholesterol content diet (1.25 %) (for 90 days) and controlled cocoa butter content diet (7.5 %) (for 90 days) |
Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. |
body mass |
male |
450 days-540 days |
10 |
7.6 |
g |
2.6 |
8.22 |
body weighing method |
0.0 |
0 |
|
108001 |
3108 |
GK/Jpe |
body weight gain |
controlled cholesterol content diet (1.25 %) (for 90 days) and controlled cocoa butter content diet (7.5 %) (for 90 days) then lipoic acid (50 mg/kg) (for 90 days) |
Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. |
body mass |
male |
450 days-540 days |
10 |
11.9 |
g |
3.7 |
11.7 |
body weighing method |
0.0 |
0 |
|
108003 |
3108 |
GK/Jpe |
blood glucose level |
fasting (for 15 hours) then glucose solution (1.75 g/kg) (for 2 hours) |
Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. |
blood glucose amount |
male |
540 days
| 20 |
332.5 |
mg/dl |
47.7 |
213.32 |
intraperitoneal glucose tolerance test |
0.0 |
120 |
min |
108010 |
3108 |
GK/Jpe |
serum triglyceride level |
controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and lipoic acid (50 mg/kg) (for 90 days) then fasting (for 15 hours) |
Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. |
blood triglyceride amount |
male |
540 days
| 7 |
116.81 |
mg/dl |
14.16 |
37.46 |
colorimetry |
0.0 |
0 |
|
110884 |
3193 |
GK/Jpe |
serum uric acid level |
controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and lipoic acid (50 mg/kg) (for 90 days) then fasting (for 15 hours) |
Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. |
blood uric acid amount |
male |
540 days
| 7 |
0.02 |
umol/l |
0.0 |
0.0 |
blood uric acid analysis |
0.0 |
0 |
|
110935 |
3193 |
GK/Jpe |
urine 8-hydroxy-2'-deoxyguanosine level |
fasting (for 15 hours) |
Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. |
urine molecular composition trait |
male |
540 days
| 7 |
306.57 |
ng/d |
23.76 |
62.86 |
enzyme linked immunosorbent assay |
0.0 |
0 |
|
110927 |
3193 |
GK/Jpe |
acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
control condition |
Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. |
vasodilation trait |
male |
540 days
| 7 |
45.0 |
% |
2.2 |
5.82 |
tissue force analysis utilizing a force transducer |
0.0 |
0 |
|
109100 |
3108 |
GK/Jpe |
serum total cholesterol level |
controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and soybean oil (2 ml/kg) (for 90 days) then fasting (for 15 hours) |
Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. |
blood cholesterol amount |
male |
540 days
| 7 |
145.56 |
mg/dl |
21.62 |
57.21 |
colorimetry |
0.0 |
0 |
|
110873 |
3193 |
GK/Jpe |
serum total bilirubin level |
controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) then fasting (for 15 hours) |
Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. |
blood bilirubin amount |
male |
540 days
| 7 |
0.14 |
mg/dl |
0.02 |
0.05 |
ex vivo blood analysis |
0.0 |
0 |
|
110892 |
3193 |
GK/Jpe |
serum alanine aminotransferase activity level |
controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) then fasting (for 15 hours) |
Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. |
blood alanine transaminase amount |
male |
540 days
| 7 |
40.1 |
U/l |
4.3 |
11.38 |
blood enzyme activity assay |
0.0 |
0 |
|
110902 |
3193 |
GK/Jpe |
serum alanine aminotransferase activity level |
controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and lipoic acid (50 mg/kg) (for 90 days) then fasting (for 15 hours) |
Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. |
blood alanine transaminase amount |
male |
540 days
| 7 |
37.5 |
U/l |
1.3 |
3.44 |
blood enzyme activity assay |
0.0 |
0 |
|
110904 |
3193 |
GK/Jpe |
blood glucose level |
fasting (for 15 hours) then glucose solution (1.75 g/kg) (for 2 hours) |
Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. |
blood glucose amount |
male |
540 days
| 7 |
332.1 |
mg/dl |
48.6 |
128.58 |
intraperitoneal glucose tolerance test |
0.0 |
0 |
|
110866 |
3193 |
GK/Jpe |
blood glucose level |
controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) then fasting (for 15 hours) then glucose solution (1.75 g/kg) (for 2 hours) |
Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. |
blood glucose amount |
male |
540 days
| 7 |
418.68 |
mg/dl |
28.8 |
76.2 |
intraperitoneal glucose tolerance test |
0.0 |
0 |
|
110867 |
3193 |
GK/Jpe |
blood glucose level |
controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and lipoic acid (50 mg/kg) then fasting (for 15 hours) then glucose solution (1.75 g/kg) (for 2 hours) |
Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. |
blood glucose amount |
male |
540 days
| 7 |
363.6 |
mg/dl |
9.0 |
23.81 |
intraperitoneal glucose tolerance test |
0.0 |
0 |
|
110869 |
3193 |
GK/Jpe |
serum non-high density lipoprotein cholesterol level |
controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and lipoic acid (50 mg/kg) (for 90 days) then fasting (for 15 hours) |
Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. |
blood cholesterol amount |
male |
540 days
| 7 |
1.11 |
mmol/l |
0.16 |
0.42 |
colorimetry |
0.0 |
0 |
|
110879 |
3193 |
GK/Jpe |
serum alkaline phosphatase activity level |
controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) then fasting (for 15 hours) |
Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. |
blood alkaline phosphatase amount |
male |
540 days
| 7 |
157.3 |
U/l |
9.8 |
25.93 |
blood enzyme activity assay |
0.0 |
0 |
|
110908 |
3193 |
GK/Jpe |
serum aspartate aminotransferase activity level |
controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) then fasting (for 15 hours) |
Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. |
blood aspartate transaminase amount |
male |
540 days
| 7 |
176.0 |
U/l |
7.4 |
19.58 |
blood enzyme activity assay |
0.0 |
0 |
|
110897 |
3193 |
GK/Jpe |
blood glucose level |
controlled cholesterol content diet (1.25 %) (for 90 days) and controlled cocoa butter content diet (7.5 g/kg) (for 90 days) then soybean oil (2 ml/kg) then fasting (2 ml/kg) (for 15 hours) then glucose solution (1.75 g/kg) (for 2 hours) |
Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. |
blood glucose amount |
male |
540 days
| 10 |
338.6 |
mg/dl |
23.4 |
74.0 |
intraperitoneal glucose tolerance test |
0.0 |
120 |
min |
108012 |
3108 |
GK/Jpe |
blood glucose level |
controlled cholesterol content diet (1.25 %) (for 90 days) and controlled cocoa butter content diet (7.5 %) (for 90 days) then lipoic acid (50 mg/kg) then fasting (for 15 hours) then glucose solution (1.75 g/kg) (for 2 hours) |
Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. |
blood glucose amount |
male |
540 days
| 10 |
365.6 |
mg/dl |
9.5 |
30.04 |
intraperitoneal glucose tolerance test |
0.0 |
120 |
min |
108013 |
3108 |
GK/Jpe |
plasma free fatty acids level |
control condition |
Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. |
blood free fatty acid amount |
male |
540 days
| 20 |
0.74 |
mmol/l |
0.1 |
0.45 |
enzymatic lipid assay |
0.0 |
0 |
|
108015 |
3108 |
GK/Jpe |
plasma free fatty acids level |
controlled cholesterol content diet (1.25 %) (for 90 days) and controlled cocoa butter content diet (7.5 %) (for 90 days) |
Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. |
blood free fatty acid amount |
male |
540 days
| 10 |
0.69 |
mmol/l |
0.09 |
0.28 |
enzymatic lipid assay |
0.0 |
0 |
|
108016 |
3108 |
GK/Jpe |
urine albumin excretion rate |
controlled cholesterol content diet (1.25 %) (for 90 days) and controlled cocoa butter content diet (7.5 %) (for 90 days) |
Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. |
urine albumin amount |
male |
540 days
| 10 |
35.7 |
mg/d |
4.1 |
12.97 |
urine albumin analysis |
0.0 |
0 |
|
108021 |
3108 |
GK/Jpe |
urine albumin excretion rate |
controlled cholesterol content diet (1.25 %) (for 90 days) and controlled cocoa butter content diet (7.5 %) (for 90 days) and lipoic acid (50 mg/kg) (for 90 days) |
Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. |
urine albumin amount |
male |
540 days
| 10 |
17.8 |
mg/d |
2.9 |
9.17 |
urine albumin analysis |
0.0 |
0 |
|
108023 |
3108 |
GK/Jpe |
serum alkaline phosphatase activity level |
fasting (for 15 hours) |
Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. |
blood alkaline phosphatase amount |
male |
540 days
| 7 |
137.1 |
U/l |
10.5 |
27.78 |
blood enzyme activity assay |
0.0 |
0 |
|
110907 |
3193 |
GK/Jpe |
liver weight to body weight ratio |
controlled cocoa butter content diet (7.5 null) (for 90 days) and controlled cholesterol content diet (1.25 null) (for 90 days) and soybean oil (2 ml/kg) (for 90 days) |
Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. |
liver mass |
male |
540 days
| 7 |
19.1 |
g/kg |
1.1 |
2.91 |
post excision weight measurement |
0.0 |
0 |
|
110858 |
3193 |
GK/Jpe |
blood glucose level |
controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) then fasting (for 15 hours) |
Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. |
blood glucose amount |
male |
540 days
| 7 |
151.56 |
mg/dl |
7.2 |
19.05 |
blood glucose test strip read by electrochemical glucometer |
0.0 |
0 |
|
110862 |
3193 |
GK/Jpe |
urine 8-hydroxy-2'-deoxyguanosine level |
controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and soybean oil (2 ml/kg) (for 90 days) then fasting (for 15 hours) |
Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. |
urine molecular composition trait |
male |
540 days
| 7 |
302.37 |
ng/d |
42.34 |
112.02 |
enzyme linked immunosorbent assay |
0.0 |
0 |
|
110929 |
3193 |
GK/Jpe |
acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled cholesterol content diet (1.25 %) (for 90 days) and controlled cocoa butter content diet (7.5 %) (for 90 days) |
Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. |
vasodilation trait |
male |
540 days
| 7 |
49.0 |
% |
3.2 |
8.47 |
tissue force analysis utilizing a force transducer |
0.0 |
0 |
|
109101 |
3108 |
GK/Jpe |
serum triglyceride level |
controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) then fasting (for 15 hours) |
Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. |
blood triglyceride amount |
male |
540 days
| 7 |
551.33 |
mg/dl |
84.96 |
224.77 |
colorimetry |
0.0 |
0 |
|
110882 |
3193 |
GK/Jpe |
serum albumin level |
controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) then fasting (for 15 hours) |
Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. |
blood albumin amount |
male |
540 days
| 7 |
2.6 |
g/dl |
0.04 |
0.11 |
blood protein analysis |
0.0 |
0 |
|
110887 |
3193 |
GK/Jpe |
serum albumin level |
controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and soybean oil (2 ml/kg) (for 90 days) then fasting (for 15 hours) |
Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. |
blood albumin amount |
male |
540 days
| 7 |
2.7 |
g/dl |
0.06 |
0.16 |
blood protein analysis |
0.0 |
0 |
|
110888 |
3193 |
GK/Jpe |
plasma malondialdehyde level |
controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and soybean oil (2 ml/kg) (for 90 days) then fasting (for 15 hours) |
Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. |
blood malondialdehyde amount |
male |
540 days
| 7 |
1.42 |
umol/l |
0.2 |
0.53 |
high-performance liquid chromatography |
0.0 |
0 |
|
110924 |
3193 |
GK/Jpe |
serum aspartate aminotransferase activity level to alanine aminotransferase activity level ratio |
controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) then fasting (for 15 hours) |
Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. |
blood aspartate transaminase amount |
male |
540 days
| 7 |
4.2 |
null |
0.2 |
0.53 |
blood enzyme activity assay |
0.0 |
0 |
|
110937 |
3193 |
GK/Jpe |
hepatic extraction fraction |
controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and lipoic acid (50 mg/kg) (for 90 days) then fasting (for 15 hours) |
Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. |
xenobiotic pharmacokinetics trait |
male |
540 days
| 7 |
97.8 |
% |
1.74 |
4.6 |
scintigraphy |
0.0 |
0 |
|
110920 |
3193 |
GK/Jpe |
serum aspartate aminotransferase activity level to alanine aminotransferase activity level ratio |
controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and soybean oil (2 ml/kg) (for 90 days) then fasting (for 15 hours) |
Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. |
blood aspartate transaminase amount |
male |
540 days
| 7 |
5.7 |
null |
0.4 |
1.06 |
blood enzyme activity assay |
0.0 |
0 |
|
110938 |
3193 |
GK/Jpe |
serum aspartate aminotransferase activity level to alanine aminotransferase activity level ratio |
controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and lipoic acid (50 mg/kg) (for 90 days) then fasting (for 15 hours) |
Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. |
blood aspartate transaminase amount |
male |
540 days
| 7 |
3.9 |
null |
0.2 |
0.53 |
blood enzyme activity assay |
0.0 |
0 |
|
110940 |
3193 |
GK/Jpe |
liver weight |
control condition |
Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. |
liver mass |
male |
540 days
| 7 |
4.84 |
g |
0.2 |
0.53 |
post excision weight measurement |
0.0 |
0 |
|
110851 |
3193 |
GK/Jpe |
liver weight |
controlled cocoa butter content diet (7.5 null) (for 90 days) and controlled cholesterol content diet (1.25 null) (for 90 days) |
Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. |
liver mass |
male |
540 days
| 7 |
11.05 |
g |
0.2 |
0.53 |
post excision weight measurement |
0.0 |
0 |
|
110852 |
3193 |
GK/Jpe |
liver weight |
controlled cocoa butter content diet (7.5 null) (for 90 days) and controlled cholesterol content diet (1.25 null) (for 90 days) and lipoic acid (50 mg/kg) |
Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. |
liver mass |
male |
540 days
| 7 |
6.37 |
g |
0.8 |
2.12 |
post excision weight measurement |
0.0 |
0 |
|
110854 |
3193 |
GK/Jpe |
liver weight to body weight ratio |
control condition |
Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. |
liver mass |
male |
540 days
| 7 |
13.6 |
g/kg |
1.9 |
5.03 |
post excision weight measurement |
0.0 |
0 |
|
110856 |
3193 |
GK/Jpe |
serum total bilirubin level |
controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and lipoic acid (50 mg/kg) (for 90 days) then fasting (for 15 hours) |
Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. |
blood bilirubin amount |
male |
540 days
| 7 |
0.18 |
mg/dl |
0.02 |
0.05 |
ex vivo blood analysis |
0.0 |
0 |
|
110894 |
3193 |
GK/Jpe |
serum gamma-glutamyltransferase activity level |
controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) then fasting (for 15 hours) |
Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. |
blood gamma-glutamyltransferase amount |
male |
540 days
| 7 |
1.9 |
U/l |
0.1 |
0.26 |
blood enzyme activity assay |
0.0 |
0 |
|
110913 |
3193 |
GK/Jpe |
acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled cholesterol content diet (1.25 %) (for 90 days) and controlled cocoa butter content diet (7.5 %) (for 90 days) then soybean oil (2 ml/kg) (for 90 days) |
Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. |
vasodilation trait |
male |
540 days
| 7 |
55.0 |
% |
2.5 |
6.61 |
tissue force analysis utilizing a force transducer |
0.0 |
0 |
|
109102 |
3108 |
GK/Jpe |
liver weight to body weight ratio |
controlled cocoa butter content diet (7.5 null) (for 90 days) and controlled cholesterol content diet (1.25 null) (for 90 days) and lipoic acid (50 mg/kg) |
Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. |
liver mass |
male |
540 days
| 7 |
16.3 |
g/kg |
1.9 |
5.03 |
post excision weight measurement |
0.0 |
0 |
|
110859 |
3193 |
GK/Jpe |
blood glucose level |
controlled cholesterol content diet (1.25 %) (for 90 days) and controlled cocoa butter content diet (7.5 %) (for 90 days) then fasting (between 15 and 0.2 hours) |
Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. |
blood glucose amount |
male |
540 days
| 10 |
151.7 |
mg/dl |
7.9 |
24.98 |
blood glucose test strip read by electrochemical glucometer |
0.0 |
0 |
|
108006 |
3108 |
GK/Jpe |
blood glucose level |
controlled cholesterol content diet (1.25 %) (for 90 days) and controlled cocoa butter content diet (7.5 %) (for 90 days) then fasting (for 15 hours) then glucose solution (1.75 g/kg) (for 2 hours) |
Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. |
blood glucose amount |
male |
540 days
| 10 |
419.1 |
mg/dl |
28.5 |
90.12 |
intraperitoneal glucose tolerance test |
0.0 |
120 |
min |
108011 |
3108 |
GK/Jpe |
urine albumin excretion rate |
controlled cholesterol content diet (1.25 %) (for 90 days) and controlled cocoa butter content diet (7.5 %) (for 90 days) and soybean oil (2 ml/kg) (for 90 days) |
Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. |
urine albumin amount |
male |
540 days
| 10 |
30.9 |
mg/d |
2.8 |
8.85 |
urine albumin analysis |
0.0 |
0 |
|
108022 |
3108 |
GK/Jpe |
serum aspartate aminotransferase activity level |
fasting (for 15 hours) |
Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. |
blood aspartate transaminase amount |
male |
540 days
| 7 |
178.0 |
U/l |
15.1 |
39.95 |
blood enzyme activity assay |
0.0 |
0 |
|
110896 |
3193 |
GK/Jpe |
serum gamma-glutamyltransferase activity level |
fasting (for 15 hours) |
Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. |
blood gamma-glutamyltransferase amount |
male |
540 days
| 7 |
2.1 |
U/l |
0.1 |
0.26 |
blood enzyme activity assay |
0.0 |
0 |
|
110912 |
3193 |
GK/Jpe |
serum gamma-glutamyltransferase activity level |
controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and soybean oil (2 ml/kg) (for 90 days) then fasting (for 15 hours) |
Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. |
blood gamma-glutamyltransferase amount |
male |
540 days
| 7 |
1.6 |
U/l |
0.2 |
0.53 |
blood enzyme activity assay |
0.0 |
0 |
|
110914 |
3193 |
GK/Jpe |
logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) |
controlled cholesterol content diet (1.25 %) (for 90 days) and controlled cocoa butter content diet (7.5 %) (for 90 days) then soybean oil (2 ml/kg) (for 90 days) |
Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. |
vasodilation trait |
male |
540 days
| 7 |
-6.23 |
null |
0.23 |
0.61 |
tissue force analysis utilizing a force transducer |
0.0 |
0 |
|
109097 |
3108 |
GK/Jpe |
sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled cholesterol content diet (1.25 %) (for 90 days) and controlled cocoa butter content diet (7.5 %) (for 90 days) then soybean oil (2 ml/kg) (for 90 days) |
Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. |
vasodilation trait |
male |
540 days
| 7 |
99.5 |
% |
0.11 |
0.29 |
tissue force analysis utilizing a force transducer |
0.0 |
0 |
|
109112 |
3108 |
GK/Jpe |
serum albumin level |
fasting (for 15 hours) |
Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. |
blood albumin amount |
male |
540 days
| 7 |
2.9 |
g/dl |
0.1 |
0.26 |
blood protein analysis |
0.0 |
0 |
|
110886 |
3193 |
GK/Jpe |
blood glucose level |
controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and lipoic acid (50 mg/kg) then fasting (for 15 hours) |
Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. |
blood glucose amount |
male |
540 days
| 7 |
122.04 |
mg/dl |
5.4 |
14.29 |
blood glucose test strip read by electrochemical glucometer |
0.0 |
0 |
|
110864 |
3193 |
GK/Jpe |
hepatic extraction fraction |
fasting (for 15 hours) |
Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. |
xenobiotic pharmacokinetics trait |
male |
540 days
| 7 |
100.0 |
% |
1.5 |
3.97 |
scintigraphy |
0.0 |
0 |
|
110917 |
3193 |
GK/Jpe |
serum uric acid level |
controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and soybean oil (2 ml/kg) (for 90 days) then fasting (for 15 hours) |
Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. |
blood uric acid amount |
male |
540 days
| 7 |
0.03 |
umol/l |
0.0 |
0.01 |
blood uric acid analysis |
0.0 |
0 |
|
110934 |
3193 |
GK/Jpe |
plasma malondialdehyde level |
controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) then fasting (for 15 hours) |
Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. |
blood malondialdehyde amount |
male |
540 days
| 7 |
1.8 |
umol/l |
0.1 |
0.26 |
high-performance liquid chromatography |
0.0 |
0 |
|
110923 |
3193 |
GK/Jpe |
sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
control condition |
Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. |
vasodilation trait |
male |
540 days
| 7 |
99.6 |
% |
0.01 |
0.03 |
tissue force analysis utilizing a force transducer |
0.0 |
0 |
|
109110 |
3108 |
GK/Jpe |
sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled cholesterol content diet (1.25 %) (for 90 days) and controlled cocoa butter content diet (7.5 %) (for 90 days) then lipoic acid (50 mg/kg) (for 90 days) |
Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. |
vasodilation trait |
male |
540 days
| 7 |
99.5 |
% |
0.05 |
0.13 |
tissue force analysis utilizing a force transducer |
0.0 |
0 |
|
109113 |
3108 |
GK/Jpe |
body weight |
controlled cocoa butter content diet (7.5 null) (for 90 days) and controlled cholesterol content diet (1.25 null) (for 90 days) and soybean oil (2 ml/kg) (for 90 days) |
Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. |
body mass |
male |
540 days
| 7 |
428.8 |
g |
12.0 |
31.75 |
body weighing method |
0.0 |
0 |
|
110848 |
3193 |
GK/Jpe |
serum total bilirubin level |
fasting (for 15 hours) |
Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. |
blood bilirubin amount |
male |
540 days
| 7 |
0.16 |
mg/dl |
0.0 |
0.0 |
ex vivo blood analysis |
0.0 |
0 |
|
110891 |
3193 |
GK/Jpe |
serum alanine aminotransferase activity level |
fasting (for 15 hours) |
Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. |
blood alanine transaminase amount |
male |
540 days
| 7 |
43.6 |
U/l |
1.1 |
2.91 |
blood enzyme activity assay |
0.0 |
0 |
|
110901 |
3193 |
GK/Jpe |
serum alkaline phosphatase activity level |
controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and soybean oil (2 ml/kg) (for 90 days) then fasting (for 15 hours) |
Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. |
blood alkaline phosphatase amount |
male |
540 days
| 7 |
114.8 |
U/l |
7.8 |
20.64 |
blood enzyme activity assay |
0.0 |
0 |
|
110909 |
3193 |
GK/Jpe |
serum total cholesterol level |
controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) then fasting (for 15 hours) |
Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. |
blood cholesterol amount |
male |
540 days
| 7 |
618.15 |
mg/dl |
115.83 |
306.46 |
colorimetry |
0.0 |
0 |
|
110877 |
3193 |
GK/Jpe |
serum gamma-glutamyltransferase activity level |
controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and lipoic acid (50 mg/kg) (for 90 days) then fasting (for 15 hours) |
Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. |
blood gamma-glutamyltransferase amount |
male |
540 days
| 7 |
1.3 |
U/l |
0.2 |
0.53 |
blood enzyme activity assay |
0.0 |
0 |
|
110915 |
3193 |
GK/Jpe |
body weight gain |
control condition |
Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. |
body mass |
male |
450 days-540 days |
20 |
1.5 |
g |
0.7 |
3.13 |
body weighing method |
0.0 |
0 |
|
108000 |
3108 |
GK/Jpe |
blood glucose level |
control condition then fasting (for 15 hours) |
Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. |
blood glucose amount |
male |
540 days
| 20 |
115.3 |
mg/dl |
5.6 |
25.04 |
blood glucose test strip read by electrochemical glucometer |
0.0 |
0 |
|
108005 |
3108 |
GK/Jpe |
blood glucose level |
controlled cholesterol content diet (1.25 %) (for 90 days) and controlled cocoa butter content diet (7.5 %) (for 90 days) then soybean oil (2 ml/kg) then fasting (for 15 hours) |
Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. |
blood glucose amount |
male |
540 days
| 10 |
129.6 |
mg/dl |
4.5 |
14.23 |
blood glucose test strip read by electrochemical glucometer |
0.0 |
0 |
|
108007 |
3108 |
GK/Jpe |
plasma free fatty acids level |
controlled cholesterol content diet (1.25 %) (for 90 days) and controlled cocoa butter content diet (7.5 %) (for 90 days) and soybean oil (2 ml/kg) (for 90 days) |
Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. |
blood free fatty acid amount |
male |
540 days
| 10 |
0.9 |
mmol/l |
0.12 |
0.38 |
enzymatic lipid assay |
0.0 |
0 |
|
108017 |
3108 |
GK/Jpe |
plasma free fatty acids level |
controlled cholesterol content diet (1.25 %) (for 90 days) and controlled cocoa butter content diet (7.5 %) (for 90 days) and lipoic acid (50 mg/kg) (for 90 days) |
Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. |
blood free fatty acid amount |
male |
540 days
| 10 |
0.89 |
mmol/l |
0.06 |
0.19 |
enzymatic lipid assay |
0.0 |
0 |
|
108018 |
3108 |
GK/Jpe |
urine albumin excretion rate |
control condition |
Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. |
urine albumin amount |
male |
540 days
| 20 |
29.2 |
mg/d |
4.7 |
21.02 |
urine albumin analysis |
0.0 |
0 |
|
108020 |
3108 |
GK/Jpe |
serum albumin level |
controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and lipoic acid (50 mg/kg) (for 90 days) then fasting (for 15 hours) |
Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. |
blood albumin amount |
male |
540 days
| 7 |
2.4 |
g/dl |
0.04 |
0.11 |
blood protein analysis |
0.0 |
0 |
|
110889 |
3193 |
GK/Jpe |
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) |
controlled cholesterol content diet (1.25 %) (for 90 days) and controlled cocoa butter content diet (7.5 %) (for 90 days) |
Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. |
vasodilation trait |
male |
540 days
| 7 |
-6.4 |
null |
0.02 |
0.04 |
tissue force analysis utilizing a force transducer |
0.0 |
0 |
|
109106 |
3108 |
GK/Jpe |
plasma malondialdehyde level |
fasting (for 15 hours) |
Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. |
blood malondialdehyde amount |
male |
540 days
| 7 |
1.5 |
umol/l |
0.1 |
0.26 |
high-performance liquid chromatography |
0.0 |
0 |
|
110922 |
3193 |
GK/Jpe |
body weight |
controlled cocoa butter content diet (7.5 null) (for 90 days) and controlled cholesterol content diet (1.25 null) (for 90 days) |
Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. |
body mass |
male |
540 days
| 7 |
410.9 |
g |
5.1 |
13.49 |
body weighing method |
0.0 |
0 |
|
110861 |
3193 |
GK/Jpe |
urine 8-hydroxy-2'-deoxyguanosine level |
controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) then fasting (for 15 hours) |
Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. |
urine molecular composition trait |
male |
540 days
| 7 |
415.8 |
ng/d |
74.29 |
196.55 |
enzyme linked immunosorbent assay |
0.0 |
0 |
|
110928 |
3193 |
GK/Jpe |
serum aspartate aminotransferase activity level |
controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and soybean oil (2 ml/kg) (for 90 days) then fasting (for 15 hours) |
Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. |
blood aspartate transaminase amount |
male |
540 days
| 7 |
154.0 |
U/l |
12.4 |
32.81 |
blood enzyme activity assay |
0.0 |
0 |
|
110898 |
3193 |
GK/Jpe |
hepatic extraction fraction |
controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and soybean oil (2 ml/kg) (for 90 days) then fasting (for 15 hours) |
Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. |
xenobiotic pharmacokinetics trait |
male |
540 days
| 7 |
94.6 |
% |
1.8 |
4.76 |
scintigraphy |
0.0 |
0 |
|
110919 |
3193 |
GK/Jpe |
serum uric acid level |
fasting (for 15 hours) |
Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. |
blood uric acid amount |
male |
540 days
| 7 |
0.03 |
umol/l |
0.0 |
0.01 |
blood uric acid analysis |
0.0 |
0 |
|
110932 |
3193 |
GK/Jpe |
blood glucose level |
fasting (for 15 hours) |
Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. |
blood glucose amount |
male |
540 days
| 7 |
115.02 |
mg/dl |
7.2 |
19.05 |
blood glucose test strip read by electrochemical glucometer |
0.0 |
0 |
|
110846 |
3193 |
GK/Jpe |
body weight |
control condition |
Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. |
body mass |
male |
540 days
| 7 |
358.5 |
g |
8.7 |
23.02 |
body weighing method |
0.0 |
0 |
|
110847 |
3193 |
GK/Jpe |
body weight |
controlled cocoa butter content diet (7.5 null) (for 90 days) and controlled cholesterol content diet (1.25 null) (for 90 days) and lipoic acid (50 mg/kg) |
Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. |
body mass |
male |
540 days
| 7 |
433.9 |
g |
10.9 |
28.84 |
body weighing method |
0.0 |
0 |
|
110849 |
3193 |
GK/Jpe |
liver weight |
controlled cocoa butter content diet (7.5 null) (for 90 days) and controlled cholesterol content diet (1.25 null) (for 90 days) and soybean oil (2 ml/kg) (for 90 days) |
Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. |
liver mass |
male |
540 days
| 7 |
8.32 |
g |
0.6 |
1.59 |
post excision weight measurement |
0.0 |
0 |
|
110853 |
3193 |
GK/Jpe |
liver weight to body weight ratio |
controlled cocoa butter content diet (7.5 null) (for 90 days) and controlled cholesterol content diet (1.25 null) (for 90 days) |
Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. |
liver mass |
male |
540 days
| 7 |
27.1 |
g/kg |
0.7 |
1.85 |
post excision weight measurement |
0.0 |
0 |
|
110857 |
3193 |
GK/Jpe |
serum total cholesterol level |
controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) then fasting (for 15 hours) |
Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. |
blood cholesterol amount |
male |
540 days
| 7 |
705.4 |
mg/dl |
118.15 |
312.59 |
colorimetry |
0.0 |
0 |
|
110872 |
3193 |
GK/Jpe |
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) |
control condition |
Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. |
vasodilation trait |
male |
540 days
| 7 |
-6.4 |
null |
0.03 |
0.08 |
tissue force analysis utilizing a force transducer |
0.0 |
0 |
|
109105 |
3108 |
GK/Jpe |
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) |
controlled cholesterol content diet (1.25 %) (for 90 days) and controlled cocoa butter content diet (7.5 %) (for 90 days) then soybean oil (2 ml/kg) (for 90 days) |
Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. |
vasodilation trait |
male |
540 days
| 7 |
-6.47 |
null |
0.03 |
0.08 |
tissue force analysis utilizing a force transducer |
0.0 |
0 |
|
109107 |
3108 |
GK/Jpe |
body weight gain |
controlled cholesterol content diet (1.25 %) (for 90 days) and controlled cocoa butter content diet (7.5 %) (for 90 days) then soybean oil (2 ml/kg) (for 90 days) |
Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. |
body mass |
male |
450 days-540 days |
10 |
50.1 |
g |
6.4 |
20.24 |
body weighing method |
0.0 |
0 |
|
108002 |
3108 |
GK/Jpe |
blood glucose level |
controlled cholesterol content diet (1.25 %) (for 90 days) and controlled cocoa butter content diet (7.5 %) (for 90 days) then lipoic acid (50 mg/kg) then fasting (for 15 hours) |
Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. |
blood glucose amount |
male |
540 days
| 10 |
122.3 |
mg/dl |
9.3 |
29.41 |
blood glucose test strip read by electrochemical glucometer |
0.0 |
0 |
|
108008 |
3108 |
GK/Jpe |
blood glucose level |
controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and soybean oil (2 ml/kg) (for 90 days) then fasting (for 15 hours) |
Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. |
blood glucose amount |
male |
540 days
| 7 |
129.42 |
mg/dl |
5.4 |
14.29 |
blood glucose test strip read by electrochemical glucometer |
0.0 |
0 |
|
110863 |
3193 |
GK/Jpe |
hepatic extraction fraction |
controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) then fasting (for 15 hours) |
Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. |
xenobiotic pharmacokinetics trait |
male |
540 days
| 7 |
87.0 |
% |
2.9 |
7.67 |
scintigraphy |
0.0 |
0 |
|
110918 |
3193 |
GK/Jpe |
serum total bilirubin level |
controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and soybean oil (2 ml/kg) (for 90 days) then fasting (for 15 hours) |
Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. |
blood bilirubin amount |
male |
540 days
| 7 |
0.14 |
mg/dl |
0.04 |
0.11 |
ex vivo blood analysis |
0.0 |
0 |
|
110893 |
3193 |
GK/Jpe |
logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) |
controlled cholesterol content diet (1.25 %) (for 90 days) and controlled cocoa butter content diet (7.5 %) (for 90 days) then lipoic acid (50 mg/kg) (for 90 days) |
Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. |
vasodilation trait |
male |
540 days
| 7 |
-6.6 |
null |
0.1 |
0.26 |
tissue force analysis utilizing a force transducer |
0.0 |
0 |
|
109098 |
3108 |
GK/Jpe |
sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled cholesterol content diet (1.25 %) (for 90 days) and controlled cocoa butter content diet (7.5 %) (for 90 days) |
Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. |
vasodilation trait |
male |
540 days
| 7 |
99.5 |
% |
0.15 |
0.4 |
tissue force analysis utilizing a force transducer |
0.0 |
0 |
|
109111 |
3108 |
GK/Jpe |
serum alkaline phosphatase activity level |
controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and lipoic acid (50 mg/kg) (for 90 days) then fasting (for 15 hours) |
Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. |
blood alkaline phosphatase amount |
male |
540 days
| 7 |
125.2 |
U/l |
7.4 |
19.58 |
blood enzyme activity assay |
0.0 |
0 |
|
110910 |
3193 |
GK/Jpe |
urine 8-hydroxy-2'-deoxyguanosine level |
controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and lipoic acid (50 mg/kg) (for 90 days) then fasting (for 15 hours) |
Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. |
urine molecular composition trait |
male |
540 days
| 7 |
5.63 |
ng/d |
0.36 |
0.95 |
enzyme linked immunosorbent assay |
0.0 |
0 |
|
110930 |
3193 |
GK/Jpe |
acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled cholesterol content diet (1.25 %) (for 90 days) and controlled cocoa butter content diet (7.5 %) (for 90 days) then lipoic acid (50 mg/kg) (for 90 days) |
Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. |
vasodilation trait |
male |
540 days
| 7 |
70.0 |
% |
2.1 |
5.56 |
tissue force analysis utilizing a force transducer |
0.0 |
0 |
|
109103 |
3108 |
GK/Jpe |
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) |
controlled cholesterol content diet (1.25 %) (for 90 days) and controlled cocoa butter content diet (7.5 %) (for 90 days) then lipoic acid (50 mg/kg) (for 90 days) |
Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. |
vasodilation trait |
male |
540 days
| 7 |
-6.25 |
null |
0.07 |
0.19 |
tissue force analysis utilizing a force transducer |
0.0 |
0 |
|
109108 |
3108 |
GK/Jpe |
serum uric acid level |
controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) then fasting (for 15 hours) |
Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. |
blood uric acid amount |
male |
540 days
| 7 |
0.03 |
umol/l |
0.0 |
0.01 |
blood uric acid analysis |
0.0 |
0 |
|
110933 |
3193 |
GK/Jpe |
serum aspartate aminotransferase activity level to alanine aminotransferase activity level ratio |
fasting (for 15 hours) |
Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. |
blood aspartate transaminase amount |
male |
540 days
| 7 |
3.9 |
null |
0.1 |
0.26 |
blood enzyme activity assay |
0.0 |
0 |
|
110936 |
3193 |
GK/Jpe |
serum total cholesterol level |
fasting (for 15 hours) |
Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. |
blood cholesterol amount |
male |
540 days
| 7 |
154.44 |
mg/dl |
25.48 |
67.42 |
colorimetry |
0.0 |
0 |
|
110871 |
3193 |
GK/Jpe |
serum total cholesterol level |
controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and lipoic acid (50 mg/kg) (for 90 days) then fasting (for 15 hours) |
Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. |
blood cholesterol amount |
male |
540 days
| 7 |
92.28 |
mg/dl |
10.42 |
27.58 |
colorimetry |
0.0 |
0 |
|
110874 |
3193 |
GK/Jpe |
serum non-high density lipoprotein cholesterol level |
fasting (for 15 hours) |
Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. |
blood cholesterol amount |
male |
540 days
| 7 |
1.76 |
mmol/l |
0.51 |
1.35 |
colorimetry |
0.0 |
0 |
|
110876 |
3193 |
GK/Jpe |
serum non-high density lipoprotein cholesterol level |
controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and soybean oil (2 ml/kg) (for 90 days) then fasting (for 15 hours) |
Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. |
blood cholesterol amount |
male |
540 days
| 7 |
2.23 |
mmol/l |
0.48 |
1.27 |
colorimetry |
0.0 |
0 |
|
110878 |
3193 |
GK/Jpe |
blood glucose level |
controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and soybean oil (2 ml/kg) (for 90 days) then fasting (for 15 hours) then glucose solution (1.75 g/kg) (for 2 hours) |
Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. |
blood glucose amount |
male |
540 days
| 7 |
358.2 |
mg/dl |
14.4 |
38.1 |
intraperitoneal glucose tolerance test |
0.0 |
0 |
|
110868 |
3193 |