| SD-Lepem1Sage-/- |
plasma insulin level |
fasting (for 4 hours) |
D'souza AM, et al., Endocrinology. 2014 Apr;155(4):1268-79. doi: 10.1210/en.2013-1523. Epub 2014 Jan 27. |
blood insulin amount |
female |
42 days
| 6 |
971.88 |
mU/l |
99.84 |
244.56 |
enzyme linked immunosorbent assay |
0.0 |
|
0 |
|
|
104457 |
2949 |
| SD-Lepem1Sage-/- |
total volumetric bone mineral density |
control condition |
Vaira S, et al., Endocrinology. 2012 Nov;153(11):5622-8. doi: 10.1210/en.2012-1462. Epub 2012 Sep 4. |
femur mineral mass |
not specified |
56 days
| 10 |
441.1 |
mg/cm3 |
19.1 |
60.4 |
micro-computed tomography |
0.0 |
|
0 |
|
|
104562 |
2969 |
| SD-Lepem1Sage-/- |
serum glucose level |
fasting (for 16 hours) |
Vaira S, et al., Endocrinology. 2012 Nov;153(11):5622-8. doi: 10.1210/en.2012-1462. Epub 2012 Sep 4. |
blood glucose amount |
not specified |
42 days
| 10 |
104.6 |
mg/dl |
5.96 |
18.85 |
standard blood serum chemistry panel |
0.0 |
|
0 |
|
|
104516 |
2969 |
| SD-Lepem1Sage-/- |
serum low density lipoprotein cholesterol level |
fasting (for 16 hours) |
Vaira S, et al., Endocrinology. 2012 Nov;153(11):5622-8. doi: 10.1210/en.2012-1462. Epub 2012 Sep 4. |
blood LDL cholesterol amount |
not specified |
42 days
| 10 |
43.6 |
mg/dl |
2.63 |
8.32 |
standard blood serum chemistry panel |
0.0 |
|
0 |
|
|
104528 |
2969 |
| SD-Lepem1Sage-/- |
serum creatinine level |
fasting (for 16 hours) |
Vaira S, et al., Endocrinology. 2012 Nov;153(11):5622-8. doi: 10.1210/en.2012-1462. Epub 2012 Sep 4. |
blood creatinine amount |
not specified |
70 days
| 10 |
0.26 |
mg/dl |
|
|
standard blood serum chemistry panel |
0.0 |
|
0 |
|
|
104534 |
2969 |
| SD-Lepem1Sage-/- |
skeletal muscle triglyceride level |
control condition (for 126 days) |
D'souza AM, et al., Endocrinology. 2014 Apr;155(4):1268-79. doi: 10.1210/en.2013-1523. Epub 2014 Jan 27. |
muscle triglyceride amount |
male |
126 days
| 6 |
0.65 |
nmol/mg |
0.13 |
0.32 |
enzymatic triglyceride assay |
0.0 |
|
0 |
|
|
104451 |
2949 |
| SD-Lepem1Sage-/- |
blood glucose level |
fasting (for 16 hours) then standard diet (for 1 hours) |
D'souza AM, et al., Endocrinology. 2014 Apr;155(4):1268-79. doi: 10.1210/en.2013-1523. Epub 2014 Jan 27. |
blood glucose amount |
male |
91 days
| 6 |
185.76 |
mg/dl |
16.74 |
41.0 |
blood glucose test strip read by electrochemical glucometer |
0.0 |
|
0 |
|
|
104471 |
2949 |
| SD-Lepem1Sage-/- |
blood insulin level |
fasting (for 12 hours) |
D'souza AM, et al., Endocrinology. 2014 Apr;155(4):1268-79. doi: 10.1210/en.2013-1523. Epub 2014 Jan 27. |
blood insulin amount |
male |
91 days
| 6 |
372.94 |
mU/l |
50.29 |
123.2 |
blood insulin analysis |
0.0 |
|
0 |
|
|
104476 |
2949 |
| SD-Lepem1Sage-/- |
osteoclast cell count |
control condition |
Vaira S, et al., Endocrinology. 2012 Nov;153(11):5622-8. doi: 10.1210/en.2012-1462. Epub 2012 Sep 4. |
osteoclast quantity |
not specified |
56 days
| 10 |
64.25 |
/section |
3.38 |
10.69 |
histochemistry |
0.0 |
|
0 |
|
TRAP stain |
104566 |
2969 |
| SD-Lepem1Sage-/- |
bone section volume fraction |
control condition |
Vaira S, et al., Endocrinology. 2012 Nov;153(11):5622-8. doi: 10.1210/en.2012-1462. Epub 2012 Sep 4. |
tibia size trait |
not specified |
56 days
| 10 |
0.45 |
null |
0.02 |
0.06 |
histochemistry |
0.0 |
|
0 |
|
TRAP stain |
104570 |
2969 |
| SD-Lepem1Sage-/- |
serum triglyceride level |
fasting (for 16 hours) |
Vaira S, et al., Endocrinology. 2012 Nov;153(11):5622-8. doi: 10.1210/en.2012-1462. Epub 2012 Sep 4. |
blood triglyceride amount |
not specified |
42 days
| 10 |
234.9 |
mg/dl |
32.5 |
102.77 |
standard blood serum chemistry panel |
0.0 |
|
0 |
|
|
104512 |
2969 |
| SD-Lepem1Sage-/- |
serum glucose level |
fasting (for 16 hours) |
Vaira S, et al., Endocrinology. 2012 Nov;153(11):5622-8. doi: 10.1210/en.2012-1462. Epub 2012 Sep 4. |
blood glucose amount |
not specified |
70 days
| 10 |
93.5 |
mg/dl |
4.6 |
14.55 |
standard blood serum chemistry panel |
0.0 |
|
0 |
|
|
104518 |
2969 |
| SD-Lepem1Sage-/- |
serum glucose level |
fasting (for 6 hours) then glucose solution (2 g/kg) (for 2 hours) |
Vaira S, et al., Endocrinology. 2012 Nov;153(11):5622-8. doi: 10.1210/en.2012-1462. Epub 2012 Sep 4. |
blood glucose amount |
not specified |
42 days
| 10 |
136.8 |
mg/dl |
16.7 |
52.81 |
intraperitoneal glucose tolerance test |
0.0 |
glucose inj |
60 |
min |
|
104540 |
2969 |
| SD-Lepem1Sage-/- |
serum glucose level |
fasting (for 6 hours) then glucose solution (2 g/kg) (for 1 hours) |
Vaira S, et al., Endocrinology. 2012 Nov;153(11):5622-8. doi: 10.1210/en.2012-1462. Epub 2012 Sep 4. |
blood glucose amount |
not specified |
70 days
| 10 |
361.2 |
mg/dl |
35.67 |
112.8 |
intraperitoneal glucose tolerance test |
0.0 |
glucose inj |
60 |
min |
|
104544 |
2969 |
| SD-Lepem1Sage-/- |
blood CD4 lymphocyte count to total lymphocyte count ratio |
control condition |
Vaira S, et al., Endocrinology. 2012 Nov;153(11):5622-8. doi: 10.1210/en.2012-1462. Epub 2012 Sep 4. |
CD4-positive T cell quantity |
not specified |
84 days
| 11 |
17.16 |
% |
2.2 |
6.96 |
flow cytometry method |
0.0 |
|
0 |
|
|
104550 |
2969 |
| SD-Lepem1Sage-/- |
percentage of CD8 positive cells expressing interferon gamma |
control condition |
Vaira S, et al., Endocrinology. 2012 Nov;153(11):5622-8. doi: 10.1210/en.2012-1462. Epub 2012 Sep 4. |
CD8-positive T cell quantity |
not specified |
84 days
| 10 |
7.01 |
% |
0.78 |
2.47 |
flow cytometry method |
0.0 |
|
0 |
|
|
104556 |
2969 |
| SD-Lepem1Sage-/- |
blood glucose level area under curve (AUC) |
fasting (for 16 hours) |
D'souza AM, et al., Endocrinology. 2014 Apr;155(4):1268-79. doi: 10.1210/en.2013-1523. Epub 2014 Jan 27. |
blood glucose amount |
female |
49 days
| 6 |
21413.64 |
(mg/dl) x min |
2044.18 |
5007.2 |
blood glucose test strip read by electrochemical glucometer |
0.0 |
|
0 |
|
|
104465 |
2949 |
| SD-Lepem1Sage-/- |
liver triglyceride level |
control condition (for 126 days) |
D'souza AM, et al., Endocrinology. 2014 Apr;155(4):1268-79. doi: 10.1210/en.2013-1523. Epub 2014 Jan 27. |
liver triglyceride amount |
male |
126 days
| 6 |
10.65 |
mg/g |
1.35 |
3.32 |
enzymatic triglyceride assay |
0.0 |
|
0 |
|
|
104443 |
2949 |
| SD-Lepem1Sage-/- |
plasma insulin level |
fasting (for 4 hours) |
D'souza AM, et al., Endocrinology. 2014 Apr;155(4):1268-79. doi: 10.1210/en.2013-1523. Epub 2014 Jan 27. |
blood insulin amount |
male |
42 days
| 6 |
327.08 |
mU/l |
47.32 |
115.91 |
enzyme linked immunosorbent assay |
0.0 |
|
0 |
|
|
104455 |
2949 |
| SD-Lepem1Sage-/- |
blood glucose level area under curve (AUC) |
fasting (for 16 hours) |
D'souza AM, et al., Endocrinology. 2014 Apr;155(4):1268-79. doi: 10.1210/en.2013-1523. Epub 2014 Jan 27. |
blood glucose amount |
female |
238 days
| 6 |
24809.09 |
(mg/dl) x min |
1854.91 |
4543.58 |
blood glucose test strip read by electrochemical glucometer |
0.0 |
|
0 |
|
|
104469 |
2949 |
| SD-Lepem1Sage-/- |
blood CD8 lymphocyte count to total lymphocyte count ratio |
control condition |
Vaira S, et al., Endocrinology. 2012 Nov;153(11):5622-8. doi: 10.1210/en.2012-1462. Epub 2012 Sep 4. |
CD8-positive T cell quantity |
not specified |
84 days
| 10 |
5.7 |
% |
1.2 |
3.79 |
flow cytometry method |
0.0 |
|
0 |
|
|
104552 |
2969 |
| SD-Lepem1Sage-/- |
osteoclast surface area to total bone area ratio |
control condition |
Vaira S, et al., Endocrinology. 2012 Nov;153(11):5622-8. doi: 10.1210/en.2012-1462. Epub 2012 Sep 4. |
osteoclast morphology trait |
not specified |
56 days
| 10 |
18.46 |
% |
1.6 |
5.06 |
histochemistry |
0.0 |
|
0 |
|
TRAP stain |
104568 |
2969 |
| SD-Lepem1Sage-/- |
serum glucose level |
fasting (for 6 hours) then glucose solution (2 g/kg) (for 0.5 hours) |
Vaira S, et al., Endocrinology. 2012 Nov;153(11):5622-8. doi: 10.1210/en.2012-1462. Epub 2012 Sep 4. |
blood glucose amount |
not specified |
70 days
| 10 |
411.6 |
mg/dl |
26.98 |
85.32 |
intraperitoneal glucose tolerance test |
0.0 |
glucose inj |
60 |
min |
|
104542 |
2969 |
| SD-Lepem1Sage-/- |
percentage of CD4 positive cells expressing interferon gamma |
control condition |
Vaira S, et al., Endocrinology. 2012 Nov;153(11):5622-8. doi: 10.1210/en.2012-1462. Epub 2012 Sep 4. |
CD4-positive T cell quantity |
not specified |
84 days
| 11 |
0.84 |
% |
0.11 |
0.35 |
flow cytometry method |
0.0 |
|
0 |
|
|
104554 |
2969 |
| SD-Lepem1Sage-/- |
bone section trabecular thickness |
control condition |
Vaira S, et al., Endocrinology. 2012 Nov;153(11):5622-8. doi: 10.1210/en.2012-1462. Epub 2012 Sep 4. |
cancellous bone morphology trait |
not specified |
56 days
| 10 |
0.16 |
mm |
0.01 |
0.03 |
micro-computed tomography |
0.0 |
|
0 |
|
|
104560 |
2969 |
| SD-Lepem1Sage-/- |
liver triglyceride level |
control condition (for 126 days) |
D'souza AM, et al., Endocrinology. 2014 Apr;155(4):1268-79. doi: 10.1210/en.2013-1523. Epub 2014 Jan 27. |
liver triglyceride amount |
female |
126 days
| 6 |
16.88 |
mg/g |
0.39 |
0.95 |
enzymatic triglyceride assay |
0.0 |
|
0 |
|
|
104445 |
2949 |
| SD-Lepem1Sage-/- |
liver cholesterol level |
control condition (for 126 days) |
D'souza AM, et al., Endocrinology. 2014 Apr;155(4):1268-79. doi: 10.1210/en.2013-1523. Epub 2014 Jan 27. |
liver cholesterol amount |
male |
126 days
| 6 |
2.16 |
mg/g |
0.12 |
0.3 |
enzymatic cholesterol assay |
0.0 |
|
0 |
|
|
104447 |
2949 |
| SD-Lepem1Sage-/- |
blood glucose level area under curve (AUC) |
fasting (for 16 hours) |
D'souza AM, et al., Endocrinology. 2014 Apr;155(4):1268-79. doi: 10.1210/en.2013-1523. Epub 2014 Jan 27. |
blood glucose amount |
male |
238 days
| 6 |
25281.82 |
(mg/dl) x min |
2024.73 |
4959.55 |
blood glucose test strip read by electrochemical glucometer |
0.0 |
|
0 |
|
|
104467 |
2949 |
| SD-Lepem1Sage-/- |
blood insulin level |
fasting (for 12 hours) |
D'souza AM, et al., Endocrinology. 2014 Apr;155(4):1268-79. doi: 10.1210/en.2013-1523. Epub 2014 Jan 27. |
blood insulin amount |
female |
91 days
| 6 |
871.77 |
mU/l |
192.35 |
471.17 |
blood insulin analysis |
0.0 |
|
0 |
|
|
104480 |
2949 |
| SD-Lepem1Sage-/- |
blood insulin level |
fasting (for 12 hours) then standard diet (for 1 hours) |
D'souza AM, et al., Endocrinology. 2014 Apr;155(4):1268-79. doi: 10.1210/en.2013-1523. Epub 2014 Jan 27. |
blood insulin amount |
female |
91 days
| 6 |
4727.1 |
mU/l |
1370.6 |
3357.27 |
blood insulin analysis |
0.0 |
|
0 |
|
|
104481 |
2949 |
| SD-Lepem1Sage-/- |
serum triglyceride level |
fasting (for 16 hours) |
Vaira S, et al., Endocrinology. 2012 Nov;153(11):5622-8. doi: 10.1210/en.2012-1462. Epub 2012 Sep 4. |
blood triglyceride amount |
not specified |
70 days
| 10 |
972.9 |
mg/dl |
72.82 |
230.28 |
standard blood serum chemistry panel |
0.0 |
|
0 |
|
|
104514 |
2969 |
| SD-Lepem1Sage-/- |
serum total cholesterol level |
fasting (for 16 hours) |
Vaira S, et al., Endocrinology. 2012 Nov;153(11):5622-8. doi: 10.1210/en.2012-1462. Epub 2012 Sep 4. |
blood cholesterol amount |
not specified |
42 days
| 10 |
145.8 |
mg/dl |
4.03 |
12.74 |
standard blood serum chemistry panel |
0.0 |
|
0 |
|
|
104520 |
2969 |
| SD-Lepem1Sage-/- |
serum high density lipoprotein cholesterol level |
fasting (for 16 hours) |
Vaira S, et al., Endocrinology. 2012 Nov;153(11):5622-8. doi: 10.1210/en.2012-1462. Epub 2012 Sep 4. |
blood HDL cholesterol amount |
not specified |
70 days
| 10 |
68.5 |
mg/dl |
4.19 |
13.25 |
standard blood serum chemistry panel |
0.0 |
|
0 |
|
|
104526 |
2969 |
| SD-Lepem1Sage-/- |
serum insulin level |
fasting (for 16 hours) |
Vaira S, et al., Endocrinology. 2012 Nov;153(11):5622-8. doi: 10.1210/en.2012-1462. Epub 2012 Sep 4. |
blood insulin amount |
not specified |
28 days
| 10 |
0.0 |
mg/dl |
0.0 |
0.0 |
serum insulin analysis |
0.0 |
|
0 |
|
|
104536 |
2969 |
| SD-Lepem1Sage-/- |
bone trabecular cross-sectional area |
control condition |
Vaira S, et al., Endocrinology. 2012 Nov;153(11):5622-8. doi: 10.1210/en.2012-1462. Epub 2012 Sep 4. |
femur area |
not specified |
56 days
| 10 |
0.12 |
mm2 |
0.01 |
0.02 |
micro-computed tomography |
0.0 |
|
0 |
|
|
104564 |
2969 |
| SD-Lepem1Sage-/- |
serum creatinine level |
fasting (for 16 hours) |
Vaira S, et al., Endocrinology. 2012 Nov;153(11):5622-8. doi: 10.1210/en.2012-1462. Epub 2012 Sep 4. |
blood creatinine amount |
not specified |
42 days
| 10 |
0.27 |
mg/dl |
|
|
standard blood serum chemistry panel |
0.0 |
|
0 |
|
|
104532 |
2969 |
| SD-Lepem1Sage-/- |
serum glucose level |
fasting (for 6 hours) then glucose solution (2 g/kg) (for 2 hours) |
Vaira S, et al., Endocrinology. 2012 Nov;153(11):5622-8. doi: 10.1210/en.2012-1462. Epub 2012 Sep 4. |
blood glucose amount |
not specified |
70 days
| 10 |
181.6 |
mg/dl |
18.45 |
58.34 |
intraperitoneal glucose tolerance test |
0.0 |
glucose inj |
60 |
min |
|
104546 |
2969 |
| SD-Lepem1Sage-/- |
serum total cholesterol level |
fasting (for 16 hours) |
Vaira S, et al., Endocrinology. 2012 Nov;153(11):5622-8. doi: 10.1210/en.2012-1462. Epub 2012 Sep 4. |
blood cholesterol amount |
not specified |
70 days
| 10 |
197.4 |
mg/dl |
10.49 |
33.17 |
standard blood serum chemistry panel |
0.0 |
|
0 |
|
|
104522 |
2969 |
| SD-Lepem1Sage-/- |
serum high density lipoprotein cholesterol level |
fasting (for 16 hours) |
Vaira S, et al., Endocrinology. 2012 Nov;153(11):5622-8. doi: 10.1210/en.2012-1462. Epub 2012 Sep 4. |
blood HDL cholesterol amount |
not specified |
42 days
| 10 |
65.0 |
mg/dl |
3.14 |
9.93 |
standard blood serum chemistry panel |
0.0 |
|
0 |
|
|
104524 |
2969 |
| SD-Lepem1Sage-/- |
serum low density lipoprotein cholesterol level |
fasting (for 16 hours) |
Vaira S, et al., Endocrinology. 2012 Nov;153(11):5622-8. doi: 10.1210/en.2012-1462. Epub 2012 Sep 4. |
blood LDL cholesterol amount |
not specified |
70 days
| 10 |
46.5 |
mg/dl |
2.4 |
7.59 |
standard blood serum chemistry panel |
0.0 |
|
0 |
|
|
104530 |
2969 |
| SD-Lepem1Sage-/- |
serum glucose level |
fasting (for 6 hours) then glucose solution (2 g/kg) (for 1 hours) |
Vaira S, et al., Endocrinology. 2012 Nov;153(11):5622-8. doi: 10.1210/en.2012-1462. Epub 2012 Sep 4. |
blood glucose amount |
not specified |
42 days
| 10 |
253.9 |
mg/dl |
35.8 |
113.21 |
intraperitoneal glucose tolerance test |
0.0 |
glucose inj |
60 |
min |
|
104538 |
2969 |
| SD-Lepem1Sage-/- |
blood glucose level area under curve (AUC) |
fasting (for 16 hours) |
D'souza AM, et al., Endocrinology. 2014 Apr;155(4):1268-79. doi: 10.1210/en.2013-1523. Epub 2014 Jan 27. |
blood glucose amount |
male |
49 days
| 6 |
23172.73 |
(mg/dl) x min |
1828.73 |
4479.45 |
blood glucose test strip read by electrochemical glucometer |
0.0 |
|
0 |
|
|
104463 |
2949 |
| SD-Lepem1Sage-/- |
liver cholesterol level |
control condition (for 126 days) |
D'souza AM, et al., Endocrinology. 2014 Apr;155(4):1268-79. doi: 10.1210/en.2013-1523. Epub 2014 Jan 27. |
liver cholesterol amount |
female |
126 days
| 6 |
2.54 |
mg/g |
0.28 |
0.69 |
enzymatic cholesterol assay |
0.0 |
|
0 |
|
|
104449 |
2949 |
| SD-Lepem1Sage-/- |
skeletal muscle triglyceride level |
control condition (for 126 days) |
D'souza AM, et al., Endocrinology. 2014 Apr;155(4):1268-79. doi: 10.1210/en.2013-1523. Epub 2014 Jan 27. |
muscle triglyceride amount |
female |
126 days
| 6 |
0.46 |
nmol/mg |
0.12 |
0.29 |
enzymatic triglyceride assay |
0.0 |
|
0 |
|
|
104453 |
2949 |
| SD-Lepem1Sage-/- |
blood glucose level |
fasting (for 16 hours) then standard diet (for 1 hours) |
D'souza AM, et al., Endocrinology. 2014 Apr;155(4):1268-79. doi: 10.1210/en.2013-1523. Epub 2014 Jan 27. |
blood glucose amount |
female |
91 days
| 6 |
216.0 |
mg/dl |
23.4 |
57.32 |
blood glucose test strip read by electrochemical glucometer |
0.0 |
|
0 |
|
|
104473 |
2949 |
| SD-Lepem1Sage-/- |
blood insulin level |
fasting (for 12 hours) then standard diet (for 1 hours) |
D'souza AM, et al., Endocrinology. 2014 Apr;155(4):1268-79. doi: 10.1210/en.2013-1523. Epub 2014 Jan 27. |
blood insulin amount |
male |
91 days
| 6 |
2198.55 |
mU/l |
95.59 |
234.14 |
blood insulin analysis |
0.0 |
|
0 |
|
|
104477 |
2949 |
| SD-Lepem1Sage-/- |
bone section mineralized tissue volume |
control condition |
Vaira S, et al., Endocrinology. 2012 Nov;153(11):5622-8. doi: 10.1210/en.2012-1462. Epub 2012 Sep 4. |
femur size trait |
not specified |
56 days
| 10 |
0.67 |
mm3 |
0.03 |
0.09 |
micro-computed tomography |
0.0 |
|
0 |
|
|
104558 |
2969 |
