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Measurement Methods
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10 | logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) | SS/HsdMcwiCrl | male | -7.4 | | controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then phenylephrine (2 umol/l) then acetylcholine (0.001-9.5 umol/l) | 84641 | controlled carbohydrate content diet (53 %) (for 63 days) | controlled fat content diet (14 %) (for 63 days) | controlled protein content diet (33 %) (for 63 days) | controlled carbohydrate content diet (69 %) (for 28 days) | controlled fat content diet (12 %) (for 28 days) | controlled protein content diet (19 %) (for 28 days) | phenylephrine (2 umol/l) | acetylcholine (0.001-9.5 umol/l) | |
6 | logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) | SS/HsdMcwiCrl | male | -7.2 | | controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then phenylephrine (2 umol/l) then acetylcholine (0.001-9.5 umol/l) | 84642 | controlled carbohydrate content diet (69 %) (for 91 days) | controlled fat content diet (12 %) (for 91 days) | controlled protein content diet (19 %) (for 91 days) | phenylephrine (2 umol/l) | | | acetylcholine (0.001-9.5 umol/l) | | |
6 | logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) | SS/HsdMcwiCrl | male | -7.2 | | controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then phenylephrine (2 umol/l) then acetylcholine (0.001-9.5 umol/l) | 84643 | controlled carbohydrate content diet (69 %) (for 63 days) | controlled fat content diet (12 %) (for 63 days) | controlled protein content diet (19 %) (for 63 days) | controlled carbohydrate content diet (53 %) (for 28 days) | controlled fat content diet (14 %) (for 28 days) | controlled protein content diet (33 %) (for 28 days) | phenylephrine (2 umol/l) | acetylcholine (0.001-9.5 umol/l) | |
5 | logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) | SS/HsdMcwiCrl | male | -6.2 | | controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) then phenylephrine (2 umol/l) then NG-nitroarginine methyl ester (100 umol/l) (for 0.2 hours) then acetylcholine (0.001-9.5 umol/l) | 84644 | controlled carbohydrate content diet (53 %) (for 91 days) | controlled fat content diet (14 %) (for 91 days) | controlled protein content diet (33 %) (for 91 days) | phenylephrine (2 umol/l) | | | NG-nitroarginine methyl ester (100 umol/l) (for 0.2 hours) | acetylcholine (0.001-9.5 umol/l) | |
8 | logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) | SS/HsdMcwiCrl | male | -6.3 | | controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then phenylephrine (2 umol/l) then NG-nitroarginine methyl ester (100 umol/l) then acetylcholine (0.001-9.5 umol/l) | 84645 | controlled carbohydrate content diet (53 %) (for 63 days) | controlled fat content diet (14 %) (for 63 days) | controlled protein content diet (33 %) (for 63 days) | controlled carbohydrate content diet (69 %) (for 28 days) | controlled fat content diet (12 %) (for 28 days) | controlled protein content diet (19 %) (for 28 days) | phenylephrine (2 umol/l) | NG-nitroarginine methyl ester (100 umol/l) | acetylcholine (0.001-9.5 umol/l) |
6 | logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) | SS/HsdMcwiCrl | male | -6.6 | | controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then phenylephrine (2 umol/l) then NG-nitroarginine methyl ester (100 umol/l) then acetylcholine (0.001-9.5 umol/l) | 84646 | controlled carbohydrate content diet (69 %) (for 91 days) | controlled fat content diet (12 %) (for 91 days) | controlled protein content diet (19 %) (for 91 days) | phenylephrine (2 umol/l) | | | NG-nitroarginine methyl ester (100 umol/l) | acetylcholine (0.001-9.5 umol/l) | |
5 | logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) | SS/HsdMcwiCrl | male | -6.7 | | controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then phenylephrine (2 umol/l) then NG-nitroarginine methyl ester (100 umol/l) then acetylcholine (0.001-9.5 umol/l) | 84647 | controlled carbohydrate content diet (69 %) (for 63 days) | controlled fat content diet (12 %) (for 63 days) | controlled protein content diet (19 %) (for 63 days) | controlled carbohydrate content diet (53 %) (for 28 days) | controlled fat content diet (14 %) (for 28 days) | controlled protein content diet (33 %) (for 28 days) | phenylephrine (2 umol/l) | NG-nitroarginine methyl ester (100 umol/l) | acetylcholine (0.001-9.5 umol/l) |
4 | logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) | SS/HsdMcwiCrl | male | -7.1 | | controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then phenylephrine (2 umol/l) then acetylcholine (0.001-9.5 umol/l) | 84640 | controlled carbohydrate content diet (53 %) (for 63 days) | controlled fat content diet (14 %) (for 63 days) | controlled protein content diet (33 %) (for 63 days) | phenylephrine (2 umol/l) | | | acetylcholine (0.001-9.5 umol/l) | | |
4 | logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) | SS/HsdMcwiCrl | male | -6.31 | | controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then phenylephrine (1 umol/l) then acetylcholine (0-95 umol/l) | 84664 | controlled carbohydrate content diet (53 %) (for 63 days) | controlled fat content diet (14 %) (for 63 days) | controlled protein content diet (33 %) (for 63 days) | phenylephrine (1 umol/l) | | | acetylcholine (0-95 umol/l) | | |
7 | logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) | SS/HsdMcwiCrl | male | -6.33 | | controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then phenylephrine (1 umol/l) then acetylcholine (0-95 umol/l) | 84665 | controlled carbohydrate content diet (53 %) (for 63 days) | controlled fat content diet (14 %) (for 63 days) | controlled protein content diet (33 %) (for 63 days) | controlled carbohydrate content diet (69 %) (for 28 days) | controlled fat content diet (12 %) (for 28 days) | controlled protein content diet (19 %) (for 28 days) | phenylephrine (1 umol/l) | acetylcholine (0-95 umol/l) | |
4 | logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) | SS/HsdMcwiCrl | male | -6.49 | | controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then phenylephrine (1 umol/l) then acetylcholine (0-95 umol/l) | 84666 | controlled carbohydrate content diet (69 %) (for 91 days) | controlled fat content diet (12 %) (for 91 days) | controlled protein content diet (19 %) (for 91 days) | phenylephrine (1 umol/l) | | | acetylcholine (0-95 umol/l) | | |
5 | logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) | SS/HsdMcwiCrl | male | -6.49 | | controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then phenylephrine (1 umol/l) then acetylcholine (0.001-95 umol/l) | 84667 | controlled carbohydrate content diet (69 %) (for 63 days) | controlled fat content diet (12 %) (for 63 days) | controlled protein content diet (19 %) (for 63 days) | controlled carbohydrate content diet (53 %) (for 28 days) | controlled fat content diet (14 %) (for 28 days) | controlled protein content diet (33 %) (for 28 days) | phenylephrine (1 umol/l) | acetylcholine (0.001-95 umol/l) | |