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# of AnimalsPhenotypeStrainSexValueUnitsConditionsRecord IDCondition 1aCondition 1bCondition 1cCondition 2aCondition 2bCondition 2cCondition 3aCondition 3bCondition 4Condition 5
7potassium chloride-induced blood vessel contractile force expressed as percent of force at baselineSS/HsdMcwiCrlmale312.35%controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) then potassium chloride solution (100 mmol/l) 84680controlled carbohydrate content diet (53 %) (for 91 days)controlled fat content diet (14 %) (for 91 days)controlled protein content diet (33 %) (for 91 days)potassium chloride solution (100 mmol/l)
10potassium chloride-induced blood vessel contractile force expressed as percent of force at baselineSS/HsdMcwiCrlmale301.44%controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then potassium chloride solution (100 mmol/l) 84681controlled carbohydrate content diet (53 %) (for 63 days)controlled fat content diet (14 %) (for 63 days)controlled protein content diet (33 %) (for 63 days)controlled carbohydrate content diet (69 %) (for 28 days)controlled fat content diet (12 %) (for 28 days)controlled protein content diet (19 %) (for 28 days)potassium chloride solution (100 mmol/l)
7phenylephrine-induced blood vessel contractile force expressed as percent of force at baselineSS/HsdMcwiCrlmale694.94%controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) then phenylephrine (31.6 umol/l) 84672controlled carbohydrate content diet (53 %) (for 91 days)controlled fat content diet (14 %) (for 91 days)controlled protein content diet (33 %) (for 91 days)phenylephrine (31.6 umol/l)
10phenylephrine-induced blood vessel contractile force expressed as percent of force at baselineSS/HsdMcwiCrlmale607.58%controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then phenylephrine (31.6 umol/l) 84673controlled carbohydrate content diet (53 %) (for 63 days)controlled fat content diet (14 %) (for 63 days)controlled protein content diet (33 %) (for 63 days)controlled carbohydrate content diet (69 %) (for 28 days)controlled fat content diet (12 %) (for 28 days)controlled protein content diet (19 %) (for 28 days)phenylephrine (31.6 umol/l)
6phenylephrine-induced blood vessel contractile force expressed as percent of force at baselineSS/HsdMcwiCrlmale542.39%controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then phenylephrine (31.6 umol/l) 84674controlled carbohydrate content diet (69 %) (for 91 days)controlled fat content diet (12 %) (for 91 days)controlled protein content diet (19 %) (for 91 days)phenylephrine (31.6 umol/l)
6phenylephrine-induced blood vessel contractile force expressed as percent of force at baselineSS/HsdMcwiCrlmale641.52%controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then phenylephrine (31.6 umol/l) 84675controlled carbohydrate content diet (69 %) (for 63 days)controlled fat content diet (12 %) (for 63 days)controlled protein content diet (19 %) (for 63 days)controlled carbohydrate content diet (53 %) (for 28 days)controlled fat content diet (14 %) (for 28 days)controlled protein content diet (33 %) (for 28 days)phenylephrine (31.6 umol/l)
7phenylephrine-induced blood vessel contractile force expressed as percent of force at baselineSS/HsdMcwiCrlmale756.89%controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) then NG-nitroarginine methyl ester (100 umol/l) (for 0.2 hours) then phenylephrine (31.6 umol/l) 84676controlled carbohydrate content diet (53 %) (for 91 days)controlled fat content diet (14 %) (for 91 days)controlled protein content diet (33 %) (for 91 days)NG-nitroarginine methyl ester (100 umol/l) (for 0.2 hours)phenylephrine (31.6 umol/l)
9phenylephrine-induced blood vessel contractile force expressed as percent of force at baselineSS/HsdMcwiCrlmale626.89%controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then NG-nitroarginine methyl ester (100 umol/l) (for 0.2 hours) then phenylephrine (31.6 umol/l) 84677controlled carbohydrate content diet (53 %) (for 63 days)controlled fat content diet (14 %) (for 63 days)controlled protein content diet (33 %) (for 63 days)controlled carbohydrate content diet (69 %) (for 28 days)controlled fat content diet (12 %) (for 28 days)controlled protein content diet (19 %) (for 28 days)NG-nitroarginine methyl ester (100 umol/l) (for 0.2 hours)phenylephrine (31.6 umol/l)
6phenylephrine-induced blood vessel contractile force expressed as percent of force at baselineSS/HsdMcwiCrlmale564.27%controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then NG-nitroarginine methyl ester (100 umol/l) (for 0.2 hours) then phenylephrine (31.6 umol/l) 84678controlled carbohydrate content diet (69 %) (for 91 days)controlled fat content diet (12 %) (for 91 days)controlled protein content diet (19 %) (for 91 days)NG-nitroarginine methyl ester (100 umol/l) (for 0.2 hours)phenylephrine (31.6 umol/l)
5phenylephrine-induced blood vessel contractile force expressed as percent of force at baselineSS/HsdMcwiCrlmale665.33%controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then NG-nitroarginine methyl ester (100 umol/l) (for 0.2 hours) then phenylephrine (31.6 umol/l) 84679controlled carbohydrate content diet (69 %) (for 63 days)controlled fat content diet (12 %) (for 63 days)controlled protein content diet (19 %) (for 63 days)controlled carbohydrate content diet (53 %) (for 28 days)controlled fat content diet (14 %) (for 28 days)controlled protein content diet (33 %) (for 28 days)NG-nitroarginine methyl ester (100 umol/l) (for 0.2 hours)phenylephrine (31.6 umol/l)
8maximum body weight loss to initial body weight ratioSS/HsdMcwiCrlmale3.6%arterial catheter implantation (for 1 days)107182arterial catheter implantation (for 1 days)
7logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)SS/HsdMcwiCrlmale-7.9controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) then phenylephrine (2 umol/l) then sodium nitroprusside (0.316 umol/l) 84648controlled carbohydrate content diet (53 %) (for 91 days)controlled fat content diet (14 %) (for 91 days)controlled protein content diet (33 %) (for 91 days)phenylephrine (2 umol/l) sodium nitroprusside (0.316 umol/l)
10logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)SS/HsdMcwiCrlmale-8controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then phenylephrine (2 umol/l) then sodium nitroprusside (0.316 umol/l) 84649controlled carbohydrate content diet (53 %) (for 63 days)controlled fat content diet (14 %) (for 63 days)controlled protein content diet (33 %) (for 63 days)controlled carbohydrate content diet (69 %) (for 28 days)controlled fat content diet (12 %) (for 28 days)controlled protein content diet (19 %) (for 28 days)phenylephrine (2 umol/l) sodium nitroprusside (0.316 umol/l)
6logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)SS/HsdMcwiCrlmale-7.9controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then phenylephrine (2 umol/l) then sodium nitroprusside (0.316 umol/l) 84650controlled carbohydrate content diet (69 %) (for 91 days)controlled fat content diet (12 %) (for 91 days)controlled protein content diet (19 %) (for 91 days)phenylephrine (2 umol/l) sodium nitroprusside (0.316 umol/l)
5logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)SS/HsdMcwiCrlmale-8.4controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then phenylephrine (2 umol/l) then sodium nitroprusside (0.316 umol/l) 84651controlled carbohydrate content diet (69 %) (for 63 days)controlled fat content diet (12 %) (for 63 days)controlled protein content diet (19 %) (for 63 days)controlled carbohydrate content diet (53 %) (for 28 days)controlled fat content diet (14 %) (for 28 days)controlled protein content diet (33 %) (for 28 days)phenylephrine (2 umol/l) sodium nitroprusside (0.316 umol/l)
6logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)SS/HsdMcwiCrlmale-8.08controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) then phenylephrine (1 umol/l) then sodium nitroprusside (0-9.5 umol/l) 84668controlled carbohydrate content diet (53 %) (for 91 days)controlled fat content diet (14 %) (for 91 days)controlled protein content diet (33 %) (for 91 days)phenylephrine (1 umol/l) sodium nitroprusside (0-9.5 umol/l)
10logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)SS/HsdMcwiCrlmale-7.93controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then phenylephrine (1 umol/l) then sodium nitroprusside (0-9.5 umol/l) 84669controlled carbohydrate content diet (53 %) (for 63 days)controlled fat content diet (14 %) (for 63 days)controlled protein content diet (33 %) (for 63 days)controlled carbohydrate content diet (69 %) (for 28 days)controlled fat content diet (12 %) (for 28 days)controlled protein content diet (19 %) (for 28 days)phenylephrine (1 umol/l) sodium nitroprusside (0-9.5 umol/l)
7logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)SS/HsdMcwiCrlmale-8.37controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then phenylephrine (1 umol/l) then sodium nitroprusside (0-9.5 umol/l) 84670controlled carbohydrate content diet (69 %) (for 91 days)controlled fat content diet (12 %) (for 91 days)controlled protein content diet (19 %) (for 91 days)phenylephrine (1 umol/l) sodium nitroprusside (0-9.5 umol/l)
6logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)SS/HsdMcwiCrlmale-8.24controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then phenylephrine (1 umol/l) then sodium nitroprusside (0-9.5 umol/l) 84671controlled carbohydrate content diet (69 %) (for 63 days)controlled fat content diet (12 %) (for 63 days)controlled protein content diet (19 %) (for 63 days)controlled carbohydrate content diet (53 %) (for 28 days)controlled fat content diet (14 %) (for 28 days)controlled protein content diet (33 %) (for 28 days)phenylephrine (1 umol/l) sodium nitroprusside (0-9.5 umol/l)
N/Aabsolute change in mean arterial blood pressureSS/HsdMcwiCrlmale-28mmHgcontrolled sodium content diet (0.15 %) (for 21 days) then dihydrocapsaicin (30 ug/kg) and pentobarbital (50 mg/kg) 67262controlled sodium content diet (0.15 %) (for 21 days)dihydrocapsaicin (30 ug/kg) pentobarbital (50 mg/kg)
N/Aabsolute change in mean arterial blood pressureSS/HsdMcwiCrlmale-23mmHgcontrolled sodium content diet (4 %) (for 21 days) then ruthenium red (3 mg/kg) then dihydrocapsaicin (30 ug/kg) and pentobarbital (50 mg/kg) 67268controlled sodium content diet (4 %) (for 21 days)ruthenium red (3 mg/kg) dihydrocapsaicin (30 ug/kg) pentobarbital (50 mg/kg)
N/Aabsolute change in mean arterial blood pressureSS/HsdMcwiCrlmale-27mmHgcontrolled sodium content diet (4 %) (for 21 days) then dihydrocapsaicin (30 ug/kg) and pentobarbital (50 mg/kg) 67264controlled sodium content diet (4 %) (for 21 days)dihydrocapsaicin (30 ug/kg) pentobarbital (50 mg/kg)
N/Aabsolute change in mean arterial blood pressureSS/HsdMcwiCrlmale-22mmHgcontrolled sodium content diet (0.15 %) (for 21 days) then ruthenium red (3 mg/kg) then dihydrocapsaicin (30 ug/kg) and pentobarbital (50 mg/kg) 67267controlled sodium content diet (0.15 %) (for 21 days)ruthenium red (3 mg/kg) dihydrocapsaicin (30 ug/kg) pentobarbital (50 mg/kg)
N/Aabsolute change in mean arterial blood pressureSS/HsdMcwiCrlmale7mmHgcontrolled sodium content diet (0.15 %) then ruthenium red (3 mg/kg) 67271controlled sodium content diet (0.15 %) ruthenium red (3 mg/kg)
N/Aabsolute change in mean arterial blood pressureSS/HsdMcwiCrlmale4mmHgcontrolled sodium content diet (4 %) then ruthenium red (3 mg/kg) 67272controlled sodium content diet (4 %) ruthenium red (3 mg/kg)
N/Aabsolute change in mean arterial blood pressureSS/HsdMcwiCrlmale-10mmHgcontrolled sodium content diet (0.15 %) then apamin (100 ug/kg) and charybdotoxin (100 ug/kg) and 4-alpha-phorbol 12,13-didecanoate (2.5 mg/kg) 67275controlled sodium content diet (0.15 %) apamin (100 ug/kg) charybdotoxin (100 ug/kg) 4-alpha-phorbol 12,13-didecanoate (2.5 mg/kg)
N/Aabsolute change in mean arterial blood pressureSS/HsdMcwiCrlmale-7mmHgcontrolled sodium content diet (4 %) then apamin (100 ug/kg) and charybdotoxin (100 ug/kg) and 4-alpha-phorbol 12,13-didecanoate (2.5 mg/kg) 67276controlled sodium content diet (4 %) apamin (100 ug/kg) charybdotoxin (100 ug/kg) 4-alpha-phorbol 12,13-didecanoate (2.5 mg/kg)
N/Aabsolute change in mean arterial blood pressureSS/HsdMcwiCrlmale-14mmHgcontrolled sodium content diet (4 %) then 4-alpha-phorbol 12,13-didecanoate (2.5 mg/kg) 67236controlled sodium content diet (4 %) 4-alpha-phorbol 12,13-didecanoate (2.5 mg/kg)
N/Aabsolute change in mean arterial blood pressureSS/HsdMcwiCrlmale-31mmHgcontrolled sodium content diet (0.15 %) then 4-alpha-phorbol 12,13-didecanoate (2.5 mg/kg) 67238controlled sodium content diet (0.15 %) 4-alpha-phorbol 12,13-didecanoate (2.5 mg/kg)
N/Aabsolute change in mean arterial blood pressureSS/HsdMcwiCrlmale-5mmHgcontrolled sodium content diet (0.15 %) then ruthenium red (3 mg/kg) then 4-alpha-phorbol 12,13-didecanoate (2.5 mg/kg) 67241controlled sodium content diet (0.15 %) ruthenium red (3 mg/kg) 4-alpha-phorbol 12,13-didecanoate (2.5 mg/kg)
N/Aabsolute change in mean arterial blood pressureSS/HsdMcwiCrlmale-4mmHgcontrolled sodium content diet (4 %) then ruthenium red (3 mg/kg) then 4-alpha-phorbol 12,13-didecanoate (2.5 mg/kg) 67242controlled sodium content diet (4 %) ruthenium red (3 mg/kg) 4-alpha-phorbol 12,13-didecanoate (2.5 mg/kg)
N/Amean arterial blood pressureSS/HsdMcwiCrlmale164mmHgcontrolled sodium content diet (4 %) 67229controlled sodium content diet (4 %)
N/Amean arterial blood pressureSS/HsdMcwiCrlmale107mmHgcontrol condition (0.15 %) 67232control condition (0.15 %)
4mean arterial blood pressureSS/HsdMcwiCrlmale109mmHgcontrolled sodium chloride content diet (0.1 %) (between 28 and 42 days)106756controlled sodium chloride content diet (0.1 %) (between 28 and 42 days)
5mean arterial blood pressureSS/HsdMcwiCrlmale149mmHgcontrolled sodium chloride content diet (8 %) (between 28 and 42 days)106776controlled sodium chloride content diet (8 %) (between 28 and 42 days)
4mean arterial blood pressureSS/HsdMcwiCrlmale153mmHgcontrolled sodium chloride content diet (8 %) (between 28 and 42 days)106758controlled sodium chloride content diet (8 %) (between 28 and 42 days)
4mean arterial blood pressureSS/HsdMcwiCrlmale150mmHgcontrolled sodium chloride content diet (8 %) (between 28 and 42 days) then 2% dimethyl sulfoxide in artificial cerebrospinal fluid (300 nl/min) (for 0.2 hours) then kynurenate (0.14 ug/min) (for 0.2 hours)106762controlled sodium chloride content diet (8 %) (between 28 and 42 days)2% dimethyl sulfoxide in artificial cerebrospinal fluid (300 nl/min) (for 0.2 hours)kynurenate (0.14 ug/min) (for 0.2 hours)
5mean arterial blood pressureSS/HsdMcwiCrlmale110mmHgcontrolled sodium chloride content diet (0.1 %) (between 28 and 42 days) then 2% dimethyl sulfoxide in artificial cerebrospinal fluid (300 nl/min) (for 0.2 hours) then kynurenate (0.14 ug/min) (for 0.2 hours)106764controlled sodium chloride content diet (0.1 %) (between 28 and 42 days)2% dimethyl sulfoxide in artificial cerebrospinal fluid (300 nl/min) (for 0.2 hours)kynurenate (0.14 ug/min) (for 0.2 hours)
4mean arterial blood pressureSS/HsdMcwiCrlmale111mmHgcontrolled sodium chloride content diet (0.1 %) (between 28 and 42 days) then candesartan (0.5 ug/min) (for 0.2 hours) then kynurenate (0.14 ug/min) (for 0.2 hours)106765controlled sodium chloride content diet (0.1 %) (between 28 and 42 days)candesartan (0.5 ug/min) (for 0.2 hours)kynurenate (0.14 ug/min) (for 0.2 hours)
5mean arterial blood pressureSS/HsdMcwiCrlmale135mmHgcontrolled sodium chloride content diet (8 %) (between 28 and 42 days) then candesartan (0.5 ug/min) (for 0.2 hours) then kynurenate (0.14 ug/min) (for 0.2 hours)106766controlled sodium chloride content diet (8 %) (between 28 and 42 days)candesartan (0.5 ug/min) (for 0.2 hours)kynurenate (0.14 ug/min) (for 0.2 hours)
4mean arterial blood pressureSS/HsdMcwiCrlmale109mmHgcontrolled sodium chloride content diet (0.1 %) (between 28 and 42 days)106767controlled sodium chloride content diet (0.1 %) (between 28 and 42 days)
5mean arterial blood pressureSS/HsdMcwiCrlmale149mmHgcontrolled sodium chloride content diet (8 %) (between 28 and 42 days)106768controlled sodium chloride content diet (8 %) (between 28 and 42 days)
5mean arterial blood pressureSS/HsdMcwiCrlmale128mmHgcontrolled sodium chloride content diet (8 %) (between 28 and 42 days) then kynurenate (0.14 ug/min) (for 0.2 hours) then candesartan (0.5 ug/min) (for 0.2 hours)106769controlled sodium chloride content diet (8 %) (between 28 and 42 days)kynurenate (0.14 ug/min) (for 0.2 hours)candesartan (0.5 ug/min) (for 0.2 hours)
8mean arterial blood pressureSS/HsdMcwiCrlmale123mmHgarterial catheter implantation (for 1 days)107336arterial catheter implantation (for 1 days)
7urine sodium excretion rateSS/HsdMcwiCrlmale6mEq/dcontrolled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days)67667controlled carbohydrate content diet (53 %) (for 91 days)controlled fat content diet (14 %) (for 91 days)controlled protein content diet (33 %) (for 91 days)
9urine sodium excretion rateSS/HsdMcwiCrlmale6.4mEq/dcontrolled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days)67668controlled carbohydrate content diet (53 %) (for 63 days)controlled fat content diet (14 %) (for 63 days)controlled protein content diet (33 %) (for 63 days)controlled carbohydrate content diet (69 %) (for 28 days)controlled fat content diet (12 %) (for 28 days)controlled protein content diet (19 %) (for 28 days)
7urine sodium excretion rateSS/HsdMcwiCrlmale9mEq/dcontrolled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days)67669controlled carbohydrate content diet (69 %) (for 91 days)controlled fat content diet (12 %) (for 91 days)controlled protein content diet (19 %) (for 91 days)
4urine sodium excretion rateSS/HsdMcwiCrlmale5.9mEq/dcontrolled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days)67670controlled carbohydrate content diet (69 %) (for 63 days)controlled fat content diet (12 %) (for 63 days)controlled protein content diet (19 %) (for 63 days)controlled carbohydrate content diet (53 %) (for 28 days)controlled fat content diet (14 %) (for 28 days)controlled protein content diet (33 %) (for 28 days)
8hematocritSS/HsdMcwiCrlmale39.3%arterial catheter implantation (for 1 days)107240arterial catheter implantation (for 1 days)
8hematocritSS/HsdMcwiCrlmale28.2%arterial catheter implantation (for 1 days) then controlled hemorrhage (between 1 and 6 hours)107256arterial catheter implantation (for 1 days)controlled hemorrhage (between 1 and 6 hours)
7acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vesselSS/HsdMcwiCrlmale98.24%controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then phenylephrine (2 umol/l) then sodium nitroprusside (0.316 umol/l) 67673controlled carbohydrate content diet (69 %) (for 91 days)controlled fat content diet (12 %) (for 91 days)controlled protein content diet (19 %) (for 91 days)phenylephrine (2 umol/l) sodium nitroprusside (0.316 umol/l)
6acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vesselSS/HsdMcwiCrlmale99.71%controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) then phenylephrine (2 umol/l) then acetylcholine (3.16 umol/l) 69616controlled carbohydrate content diet (53 %) (for 91 days)controlled fat content diet (14 %) (for 91 days)controlled protein content diet (33 %) (for 91 days)phenylephrine (2 umol/l) acetylcholine (3.16 umol/l)
10acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vesselSS/HsdMcwiCrlmale99.53%controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then phenylephrine (2 umol/l) then acetylcholine (3.16 umol/l) 69617controlled carbohydrate content diet (53 %) (for 63 days)controlled fat content diet (14 %) (for 63 days)controlled protein content diet (33 %) (for 63 days)controlled carbohydrate content diet (69 %) (for 28 days)controlled fat content diet (12 %) (for 28 days)controlled protein content diet (19 %) (for 28 days)phenylephrine (2 umol/l) acetylcholine (3.16 umol/l)
6acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vesselSS/HsdMcwiCrlmale100.24%controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then phenylephrine (2 umol/l) then acetylcholine (3.16 umol/l) 69618controlled carbohydrate content diet (69 %) (for 91 days)controlled fat content diet (12 %) (for 91 days)controlled protein content diet (19 %) (for 91 days)phenylephrine (2 umol/l) acetylcholine (3.16 umol/l)
6acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vesselSS/HsdMcwiCrlmale100.14%controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then phenylephrine (2 umol/l) then acetylcholine (3.16 umol/l) 69619controlled carbohydrate content diet (69 %) (for 63 days)controlled fat content diet (12 %) (for 63 days)controlled protein content diet (19 %) (for 63 days)controlled carbohydrate content diet (53 %) (for 28 days)controlled fat content diet (14 %) (for 28 days)controlled protein content diet (33 %) (for 28 days)phenylephrine (2 umol/l) acetylcholine (3.16 umol/l)
5acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vesselSS/HsdMcwiCrlmale94.99%controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) then phenylephrine (2 umol/l) then NG-nitroarginine methyl ester (100 umol/l) (for 0.2 hours) then acetylcholine (3.16 umol/l) 69620controlled carbohydrate content diet (53 %) (for 91 days)controlled fat content diet (14 %) (for 91 days)controlled protein content diet (33 %) (for 91 days)phenylephrine (2 umol/l) NG-nitroarginine methyl ester (100 umol/l) (for 0.2 hours)acetylcholine (3.16 umol/l)
10acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vesselSS/HsdMcwiCrlmale64.5%controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then phenylephrine (2 umol/l) then NG-nitroarginine methyl ester (100 umol/l) then acetylcholine (3.16 umol/l) 69621controlled carbohydrate content diet (53 %) (for 63 days)controlled fat content diet (14 %) (for 63 days)controlled protein content diet (33 %) (for 63 days)controlled carbohydrate content diet (69 %) (for 28 days)controlled fat content diet (12 %) (for 28 days)controlled protein content diet (19 %) (for 28 days)phenylephrine (2 umol/l) NG-nitroarginine methyl ester (100 umol/l) acetylcholine (3.16 umol/l)
6acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vesselSS/HsdMcwiCrlmale91.96%controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then phenylephrine (2 umol/l) then NG-nitroarginine methyl ester (100 umol/l) then acetylcholine (3.16 umol/l) 69622controlled carbohydrate content diet (69 %) (for 91 days)controlled fat content diet (12 %) (for 91 days)controlled protein content diet (19 %) (for 91 days)phenylephrine (2 umol/l) NG-nitroarginine methyl ester (100 umol/l) acetylcholine (3.16 umol/l)
6acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vesselSS/HsdMcwiCrlmale92.95%controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then phenylephrine (2 umol/l) then NG-nitroarginine methyl ester (100 umol/l) then acetylcholine (3.16 umol/l) 69623controlled carbohydrate content diet (69 %) (for 63 days)controlled fat content diet (12 %) (for 63 days)controlled protein content diet (19 %) (for 63 days)controlled carbohydrate content diet (53 %) (for 28 days)controlled fat content diet (14 %) (for 28 days)controlled protein content diet (33 %) (for 28 days)phenylephrine (2 umol/l) NG-nitroarginine methyl ester (100 umol/l) acetylcholine (3.16 umol/l)
4acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vesselSS/HsdMcwiCrlmale70.84%controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) then phenylephrine (1 umol/l) then acetylcholine (31.6 umol/l) 84652controlled carbohydrate content diet (53 %) (for 91 days)controlled fat content diet (14 %) (for 91 days)controlled protein content diet (33 %) (for 91 days)phenylephrine (1 umol/l) acetylcholine (31.6 umol/l)
7acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vesselSS/HsdMcwiCrlmale73.42%controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then phenylephrine (1 umol/l) then acetylcholine (31.6 umol/l) 84653controlled carbohydrate content diet (53 %) (for 63 days)controlled fat content diet (14 %) (for 63 days)controlled protein content diet (33 %) (for 63 days)controlled carbohydrate content diet (69 %) (for 28 days)controlled fat content diet (12 %) (for 28 days)controlled protein content diet (19 %) (for 28 days)phenylephrine (1 umol/l) acetylcholine (31.6 umol/l)
4acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vesselSS/HsdMcwiCrlmale80.04%controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then phenylephrine (1 umol/l) then acetylcholine (31.6 umol/l) 84654controlled carbohydrate content diet (69 %) (for 91 days)controlled fat content diet (12 %) (for 91 days)controlled protein content diet (19 %) (for 91 days)phenylephrine (1 umol/l) acetylcholine (31.6 umol/l)
5acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vesselSS/HsdMcwiCrlmale78.37%controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then phenylephrine (1 umol/l) then acetylcholine (31.6 umol/l) 84655controlled carbohydrate content diet (69 %) (for 63 days)controlled fat content diet (12 %) (for 63 days)controlled protein content diet (19 %) (for 63 days)controlled carbohydrate content diet (53 %) (for 28 days)controlled fat content diet (14 %) (for 28 days)controlled protein content diet (33 %) (for 28 days)phenylephrine (1 umol/l) acetylcholine (31.6 umol/l)
6acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vesselSS/HsdMcwiCrlmale-19.03%controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) then phenylephrine (1 umol/l) then NG-nitroarginine methyl ester (100 umol/l) (for 0.2 hours) then acetylcholine (31.6 umol/l) 84656controlled carbohydrate content diet (53 %) (for 91 days)controlled fat content diet (14 %) (for 91 days)controlled protein content diet (33 %) (for 91 days)phenylephrine (1 umol/l) NG-nitroarginine methyl ester (100 umol/l) (for 0.2 hours)acetylcholine (31.6 umol/l)
10acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vesselSS/HsdMcwiCrlmale-29.33%controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then phenylephrine (1 umol/l) then NG-nitroarginine methyl ester (100 umol/l) then acetylcholine (31.6 umol/l) 84657controlled carbohydrate content diet (53 %) (for 63 days)controlled fat content diet (14 %) (for 63 days)controlled protein content diet (33 %) (for 63 days)controlled carbohydrate content diet (69 %) (for 28 days)controlled fat content diet (12 %) (for 28 days)controlled protein content diet (19 %) (for 28 days)phenylephrine (1 umol/l) NG-nitroarginine methyl ester (100 umol/l) acetylcholine (31.6 umol/l)
7acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vesselSS/HsdMcwiCrlmale-12.94%controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then phenylephrine (1 umol/l) then NG-nitroarginine methyl ester (100 umol/l) then acetylcholine (31.6 umol/l) 84658controlled carbohydrate content diet (69 %) (for 91 days)controlled fat content diet (12 %) (for 91 days)controlled protein content diet (19 %) (for 91 days)phenylephrine (1 umol/l) NG-nitroarginine methyl ester (100 umol/l) acetylcholine (31.6 umol/l)
6acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vesselSS/HsdMcwiCrlmale-16.62%controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then phenylephrine (1 umol/l) then NG-nitroarginine methyl ester (100 umol/l) then acetylcholine (31.6 umol/l) 84659controlled carbohydrate content diet (69 %) (for 63 days)controlled fat content diet (12 %) (for 63 days)controlled protein content diet (19 %) (for 63 days)controlled carbohydrate content diet (53 %) (for 28 days)controlled fat content diet (14 %) (for 28 days)controlled protein content diet (33 %) (for 28 days)phenylephrine (1 umol/l) NG-nitroarginine methyl ester (100 umol/l) acetylcholine (31.6 umol/l)
N/Aacetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vesselSS/HsdMcwiCrlmale95.47%controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then phenylephrine (1 umol/l) then sodium nitroprusside (3.16 umol/l) 84662controlled carbohydrate content diet (69 %) (for 91 days)controlled fat content diet (12 %) (for 91 days)controlled protein content diet (19 %) (for 91 days)phenylephrine (1 umol/l) sodium nitroprusside (3.16 umol/l)
10logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)SS/HsdMcwiCrlmale-7.4controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then phenylephrine (2 umol/l) then acetylcholine (0.001-9.5 umol/l) 84641controlled carbohydrate content diet (53 %) (for 63 days)controlled fat content diet (14 %) (for 63 days)controlled protein content diet (33 %) (for 63 days)controlled carbohydrate content diet (69 %) (for 28 days)controlled fat content diet (12 %) (for 28 days)controlled protein content diet (19 %) (for 28 days)phenylephrine (2 umol/l) acetylcholine (0.001-9.5 umol/l)
6logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)SS/HsdMcwiCrlmale-7.2controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then phenylephrine (2 umol/l) then acetylcholine (0.001-9.5 umol/l) 84642controlled carbohydrate content diet (69 %) (for 91 days)controlled fat content diet (12 %) (for 91 days)controlled protein content diet (19 %) (for 91 days)phenylephrine (2 umol/l) acetylcholine (0.001-9.5 umol/l)
6logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)SS/HsdMcwiCrlmale-7.2controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then phenylephrine (2 umol/l) then acetylcholine (0.001-9.5 umol/l) 84643controlled carbohydrate content diet (69 %) (for 63 days)controlled fat content diet (12 %) (for 63 days)controlled protein content diet (19 %) (for 63 days)controlled carbohydrate content diet (53 %) (for 28 days)controlled fat content diet (14 %) (for 28 days)controlled protein content diet (33 %) (for 28 days)phenylephrine (2 umol/l) acetylcholine (0.001-9.5 umol/l)
5logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)SS/HsdMcwiCrlmale-6.2controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) then phenylephrine (2 umol/l) then NG-nitroarginine methyl ester (100 umol/l) (for 0.2 hours) then acetylcholine (0.001-9.5 umol/l) 84644controlled carbohydrate content diet (53 %) (for 91 days)controlled fat content diet (14 %) (for 91 days)controlled protein content diet (33 %) (for 91 days)phenylephrine (2 umol/l) NG-nitroarginine methyl ester (100 umol/l) (for 0.2 hours)acetylcholine (0.001-9.5 umol/l)
8logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)SS/HsdMcwiCrlmale-6.3controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then phenylephrine (2 umol/l) then NG-nitroarginine methyl ester (100 umol/l) then acetylcholine (0.001-9.5 umol/l) 84645controlled carbohydrate content diet (53 %) (for 63 days)controlled fat content diet (14 %) (for 63 days)controlled protein content diet (33 %) (for 63 days)controlled carbohydrate content diet (69 %) (for 28 days)controlled fat content diet (12 %) (for 28 days)controlled protein content diet (19 %) (for 28 days)phenylephrine (2 umol/l) NG-nitroarginine methyl ester (100 umol/l) acetylcholine (0.001-9.5 umol/l)
6logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)SS/HsdMcwiCrlmale-6.6controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then phenylephrine (2 umol/l) then NG-nitroarginine methyl ester (100 umol/l) then acetylcholine (0.001-9.5 umol/l) 84646controlled carbohydrate content diet (69 %) (for 91 days)controlled fat content diet (12 %) (for 91 days)controlled protein content diet (19 %) (for 91 days)phenylephrine (2 umol/l) NG-nitroarginine methyl ester (100 umol/l) acetylcholine (0.001-9.5 umol/l)
5logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)SS/HsdMcwiCrlmale-6.7controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then phenylephrine (2 umol/l) then NG-nitroarginine methyl ester (100 umol/l) then acetylcholine (0.001-9.5 umol/l) 84647controlled carbohydrate content diet (69 %) (for 63 days)controlled fat content diet (12 %) (for 63 days)controlled protein content diet (19 %) (for 63 days)controlled carbohydrate content diet (53 %) (for 28 days)controlled fat content diet (14 %) (for 28 days)controlled protein content diet (33 %) (for 28 days)phenylephrine (2 umol/l) NG-nitroarginine methyl ester (100 umol/l) acetylcholine (0.001-9.5 umol/l)
4logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)SS/HsdMcwiCrlmale-7.1controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then phenylephrine (2 umol/l) then acetylcholine (0.001-9.5 umol/l) 84640controlled carbohydrate content diet (53 %) (for 63 days)controlled fat content diet (14 %) (for 63 days)controlled protein content diet (33 %) (for 63 days)phenylephrine (2 umol/l) acetylcholine (0.001-9.5 umol/l)
4logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)SS/HsdMcwiCrlmale-6.31controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then phenylephrine (1 umol/l) then acetylcholine (0-95 umol/l) 84664controlled carbohydrate content diet (53 %) (for 63 days)controlled fat content diet (14 %) (for 63 days)controlled protein content diet (33 %) (for 63 days)phenylephrine (1 umol/l) acetylcholine (0-95 umol/l)
7logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)SS/HsdMcwiCrlmale-6.33controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then phenylephrine (1 umol/l) then acetylcholine (0-95 umol/l) 84665controlled carbohydrate content diet (53 %) (for 63 days)controlled fat content diet (14 %) (for 63 days)controlled protein content diet (33 %) (for 63 days)controlled carbohydrate content diet (69 %) (for 28 days)controlled fat content diet (12 %) (for 28 days)controlled protein content diet (19 %) (for 28 days)phenylephrine (1 umol/l) acetylcholine (0-95 umol/l)
4logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)SS/HsdMcwiCrlmale-6.49controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then phenylephrine (1 umol/l) then acetylcholine (0-95 umol/l) 84666controlled carbohydrate content diet (69 %) (for 91 days)controlled fat content diet (12 %) (for 91 days)controlled protein content diet (19 %) (for 91 days)phenylephrine (1 umol/l) acetylcholine (0-95 umol/l)
5logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)SS/HsdMcwiCrlmale-6.49controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then phenylephrine (1 umol/l) then acetylcholine (0.001-95 umol/l) 84667controlled carbohydrate content diet (69 %) (for 63 days)controlled fat content diet (12 %) (for 63 days)controlled protein content diet (19 %) (for 63 days)controlled carbohydrate content diet (53 %) (for 28 days)controlled fat content diet (14 %) (for 28 days)controlled protein content diet (33 %) (for 28 days)phenylephrine (1 umol/l) acetylcholine (0.001-95 umol/l)
8water drink intake rateSS/HsdMcwiCrlmale30.1ml/dcontrolled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days)67663controlled carbohydrate content diet (53 %) (for 91 days)controlled fat content diet (14 %) (for 91 days)controlled protein content diet (33 %) (for 91 days)
9water drink intake rateSS/HsdMcwiCrlmale21.8ml/dcontrolled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days)67664controlled carbohydrate content diet (53 %) (for 63 days)controlled fat content diet (14 %) (for 63 days)controlled protein content diet (33 %) (for 63 days)controlled carbohydrate content diet (69 %) (for 28 days)controlled fat content diet (12 %) (for 28 days)controlled protein content diet (19 %) (for 28 days)
7water drink intake rateSS/HsdMcwiCrlmale18.4ml/dcontrolled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days)67665controlled carbohydrate content diet (69 %) (for 91 days)controlled fat content diet (12 %) (for 91 days)controlled protein content diet (19 %) (for 91 days)
5water drink intake rateSS/HsdMcwiCrlmale30.1ml/dcontrolled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days)67666controlled carbohydrate content diet (69 %) (for 63 days)controlled fat content diet (12 %) (for 63 days)controlled protein content diet (19 %) (for 63 days)controlled carbohydrate content diet (53 %) (for 28 days)controlled fat content diet (14 %) (for 28 days)controlled protein content diet (33 %) (for 28 days)
4heart rateSS/HsdMcwiCrlmale444beats/mincontrolled sodium chloride content diet (0.1 %) (between 28 and 42 days)106774controlled sodium chloride content diet (0.1 %) (between 28 and 42 days)
5heart rateSS/HsdMcwiCrlmale454beats/mincontrolled sodium chloride content diet (8 %) (between 28 and 42 days)106775controlled sodium chloride content diet (8 %) (between 28 and 42 days)
5heart rateSS/HsdMcwiCrlmale444beats/mincontrolled sodium chloride content diet (8 %) (between 28 and 42 days)106777controlled sodium chloride content diet (8 %) (between 28 and 42 days)
4heart rateSS/HsdMcwiCrlmale442beats/mincontrolled sodium chloride content diet (0.1 %) (between 28 and 42 days) then 2% dimethyl sulfoxide in artificial cerebrospinal fluid (300 nl/min) (for 0.2 hours) then kynurenate (0.14 ug/min) (for 0.2 hours)106778controlled sodium chloride content diet (0.1 %) (between 28 and 42 days)2% dimethyl sulfoxide in artificial cerebrospinal fluid (300 nl/min) (for 0.2 hours)kynurenate (0.14 ug/min) (for 0.2 hours)
4heart rateSS/HsdMcwiCrlmale425beats/mincontrolled sodium chloride content diet (8 %) (between 28 and 42 days) then 2% dimethyl sulfoxide in artificial cerebrospinal fluid (300 nl/min) (for 0.2 hours) then kynurenate (0.14 ug/min) (for 0.2 hours)106779controlled sodium chloride content diet (8 %) (between 28 and 42 days)2% dimethyl sulfoxide in artificial cerebrospinal fluid (300 nl/min) (for 0.2 hours)kynurenate (0.14 ug/min) (for 0.2 hours)
4heart rateSS/HsdMcwiCrlmale459beats/mincontrolled sodium chloride content diet (0.1 %) (between 28 and 42 days) then candesartan (0.5 ug/min) (for 0.2 hours) then kynurenate (0.14 ug/min) (for 0.2 hours)106782controlled sodium chloride content diet (0.1 %) (between 28 and 42 days)candesartan (0.5 ug/min) (for 0.2 hours)kynurenate (0.14 ug/min) (for 0.2 hours)
5heart rateSS/HsdMcwiCrlmale466beats/mincontrolled sodium chloride content diet (8 %) (between 28 and 42 days) then candesartan (0.5 ug/min) (for 0.2 hours) then kynurenate (0.14 ug/min) (for 0.2 hours)106783controlled sodium chloride content diet (8 %) (between 28 and 42 days)candesartan (0.5 ug/min) (for 0.2 hours)kynurenate (0.14 ug/min) (for 0.2 hours)
5heart rateSS/HsdMcwiCrlmale410beats/mincontrolled sodium chloride content diet (8 %) (between 28 and 42 days) then kynurenate (0.14 ug/min) (for 0.2 hours) then candesartan (0.5 ug/min) (for 0.2 hours)106784controlled sodium chloride content diet (8 %) (between 28 and 42 days)kynurenate (0.14 ug/min) (for 0.2 hours)candesartan (0.5 ug/min) (for 0.2 hours)
4heart rateSS/HsdMcwiCrlmale442beats/mincontrolled sodium chloride content diet (0.1 %) (between 28 and 42 days)106770controlled sodium chloride content diet (0.1 %) (between 28 and 42 days)
4heart rateSS/HsdMcwiCrlmale435beats/mincontrolled sodium chloride content diet (8 %) (between 28 and 42 days)106771controlled sodium chloride content diet (8 %) (between 28 and 42 days)
6urine total protein excretion rateSS/HsdMcwiCrlmale0.6mg/dcontrolled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days)69612controlled carbohydrate content diet (53 %) (for 91 days)controlled fat content diet (14 %) (for 91 days)controlled protein content diet (33 %) (for 91 days)
9urine total protein excretion rateSS/HsdMcwiCrlmale1mg/dcontrolled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days)69613controlled carbohydrate content diet (53 %) (for 63 days)controlled fat content diet (14 %) (for 63 days)controlled protein content diet (33 %) (for 63 days)controlled carbohydrate content diet (69 %) (for 28 days)controlled fat content diet (12 %) (for 28 days)controlled protein content diet (19 %) (for 28 days)
6urine total protein excretion rateSS/HsdMcwiCrlmale0.7mg/dcontrolled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days)69614controlled carbohydrate content diet (69 %) (for 91 days)controlled fat content diet (12 %) (for 91 days)controlled protein content diet (19 %) (for 91 days)
6urine total protein excretion rateSS/HsdMcwiCrlmale0.8mg/dcontrolled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days)69615controlled carbohydrate content diet (69 %) (for 63 days)controlled fat content diet (12 %) (for 63 days)controlled protein content diet (19 %) (for 63 days)controlled carbohydrate content diet (53 %) (for 28 days)controlled fat content diet (14 %) (for 28 days)controlled protein content diet (33 %) (for 28 days)
7sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vesselSS/HsdMcwiCrlmale97.36%controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) then phenylephrine (2 umol/l) then sodium nitroprusside (0.316 umol/l) 67671controlled carbohydrate content diet (53 %) (for 91 days)controlled fat content diet (14 %) (for 91 days)controlled protein content diet (33 %) (for 91 days)phenylephrine (2 umol/l) sodium nitroprusside (0.316 umol/l)
10sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vesselSS/HsdMcwiCrlmale96.65%controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then phenylephrine (2 umol/l) then sodium nitroprusside (0.316 umol/l) 67672controlled carbohydrate content diet (53 %) (for 63 days)controlled fat content diet (14 %) (for 63 days)controlled protein content diet (33 %) (for 63 days)controlled carbohydrate content diet (69 %) (for 28 days)controlled fat content diet (12 %) (for 28 days)controlled protein content diet (19 %) (for 28 days)phenylephrine (2 umol/l) sodium nitroprusside (0.316 umol/l)
6sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vesselSS/HsdMcwiCrlmale98.54%controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then phenylephrine (2 umol/l) then sodium nitroprusside (0.316 umol/l) 67674controlled carbohydrate content diet (69 %) (for 63 days)controlled fat content diet (12 %) (for 63 days)controlled protein content diet (19 %) (for 63 days)controlled carbohydrate content diet (53 %) (for 28 days)controlled fat content diet (14 %) (for 28 days)controlled protein content diet (33 %) (for 28 days)phenylephrine (2 umol/l) sodium nitroprusside (0.316 umol/l)
6sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vesselSS/HsdMcwiCrlmale98.76%controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) then phenylephrine (1 umol/l) then sodium nitroprusside (3.16 umol/l) 84660controlled carbohydrate content diet (53 %) (for 91 days)controlled fat content diet (14 %) (for 91 days)controlled protein content diet (33 %) (for 91 days)phenylephrine (1 umol/l) sodium nitroprusside (3.16 umol/l)
10sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vesselSS/HsdMcwiCrlmale96.25%controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then phenylephrine (1 umol/l) then sodium nitroprusside (3.16 umol/l) 84661controlled carbohydrate content diet (53 %) (for 63 days)controlled fat content diet (14 %) (for 63 days)controlled protein content diet (33 %) (for 63 days)controlled carbohydrate content diet (69 %) (for 28 days)controlled fat content diet (12 %) (for 28 days)controlled protein content diet (19 %) (for 28 days)phenylephrine (1 umol/l) sodium nitroprusside (3.16 umol/l)
6sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vesselSS/HsdMcwiCrlmale99.39%controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then phenylephrine (1 umol/l) then sodium nitroprusside (3.16 umol/l) 84663controlled carbohydrate content diet (69 %) (for 63 days)controlled fat content diet (12 %) (for 63 days)controlled protein content diet (19 %) (for 63 days)controlled carbohydrate content diet (53 %) (for 28 days)controlled fat content diet (14 %) (for 28 days)controlled protein content diet (33 %) (for 28 days)phenylephrine (1 umol/l) sodium nitroprusside (3.16 umol/l)
7tibia lengthSS/HsdMcwiCrlmale4.24cmcontrolled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days)67610controlled carbohydrate content diet (53 %) (for 91 days)controlled fat content diet (14 %) (for 91 days)controlled protein content diet (33 %) (for 91 days)
9tibia lengthSS/HsdMcwiCrlmale4.26cmcontrolled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days)67611controlled carbohydrate content diet (53 %) (for 63 days)controlled fat content diet (14 %) (for 63 days)controlled protein content diet (33 %) (for 63 days)controlled carbohydrate content diet (69 %) (for 28 days)controlled fat content diet (12 %) (for 28 days)controlled protein content diet (19 %) (for 28 days)
6tibia lengthSS/HsdMcwiCrlmale4.3cmcontrolled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days)67612controlled carbohydrate content diet (69 %) (for 91 days)controlled fat content diet (12 %) (for 91 days)controlled protein content diet (19 %) (for 91 days)
8tibia lengthSS/HsdMcwiCrlmale4.34cmcontrolled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days)67613controlled carbohydrate content diet (69 %) (for 63 days)controlled fat content diet (12 %) (for 63 days)controlled protein content diet (19 %) (for 63 days)controlled carbohydrate content diet (53 %) (for 28 days)controlled fat content diet (14 %) (for 28 days)controlled protein content diet (33 %) (for 28 days)
8food intake rateSS/HsdMcwiCrlmale25.2g/dcontrolled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days)67659controlled carbohydrate content diet (53 %) (for 91 days)controlled fat content diet (14 %) (for 91 days)controlled protein content diet (33 %) (for 91 days)
9food intake rateSS/HsdMcwiCrlmale21.4g/dcontrolled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days)67660controlled carbohydrate content diet (53 %) (for 63 days)controlled fat content diet (14 %) (for 63 days)controlled protein content diet (33 %) (for 63 days)controlled carbohydrate content diet (69 %) (for 28 days)controlled fat content diet (12 %) (for 28 days)controlled protein content diet (19 %) (for 28 days)
7food intake rateSS/HsdMcwiCrlmale20.9g/dcontrolled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days)67661controlled carbohydrate content diet (69 %) (for 91 days)controlled fat content diet (12 %) (for 91 days)controlled protein content diet (19 %) (for 91 days)
5food intake rateSS/HsdMcwiCrlmale25.4g/dcontrolled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days)67662controlled carbohydrate content diet (69 %) (for 63 days)controlled fat content diet (12 %) (for 63 days)controlled protein content diet (19 %) (for 63 days)controlled carbohydrate content diet (53 %) (for 28 days)controlled fat content diet (14 %) (for 28 days)controlled protein content diet (33 %) (for 28 days)
8body weightSS/HsdMcwiCrlmale341gcontrol condition107348control condition
8body weight to tibia length ratioSS/HsdMcwiCrlmale97.84g/cmcontrolled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days)67617controlled carbohydrate content diet (69 %) (for 63 days)controlled fat content diet (12 %) (for 63 days)controlled protein content diet (19 %) (for 63 days)controlled carbohydrate content diet (53 %) (for 28 days)controlled fat content diet (14 %) (for 28 days)controlled protein content diet (33 %) (for 28 days)
9body weight to tibia length ratioSS/HsdMcwiCrlmale98.04g/cmcontrolled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days)67615controlled carbohydrate content diet (53 %) (for 63 days)controlled fat content diet (14 %) (for 63 days)controlled protein content diet (33 %) (for 63 days)controlled carbohydrate content diet (69 %) (for 28 days)controlled fat content diet (12 %) (for 28 days)controlled protein content diet (19 %) (for 28 days)
6body weight to tibia length ratioSS/HsdMcwiCrlmale96.12g/cmcontrolled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days)67616controlled carbohydrate content diet (69 %) (for 91 days)controlled fat content diet (12 %) (for 91 days)controlled protein content diet (19 %) (for 91 days)
7body weight to tibia length ratioSS/HsdMcwiCrlmale100.21g/cmcontrolled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days)67614controlled carbohydrate content diet (53 %) (for 91 days)controlled fat content diet (14 %) (for 91 days)controlled protein content diet (33 %) (for 91 days)
7heart weight to tibia length ratioSS/HsdMcwiCrlmale0.37g/cmcontrolled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) then controlled protein content diet (33 %) (for 91 days)67618controlled carbohydrate content diet (53 %) (for 91 days)controlled fat content diet (14 %) (for 91 days)controlled protein content diet (33 %) (for 91 days)
9heart weight to tibia length ratioSS/HsdMcwiCrlmale0.34g/cmcontrolled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days)67619controlled carbohydrate content diet (53 %) (for 63 days)controlled fat content diet (14 %) (for 63 days)controlled protein content diet (33 %) (for 63 days)controlled carbohydrate content diet (69 %) (for 28 days)controlled fat content diet (12 %) (for 28 days)controlled protein content diet (19 %) (for 28 days)
6heart weight to tibia length ratioSS/HsdMcwiCrlmale0.31g/cmcontrolled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) then controlled protein content diet (19 %) (for 91 days)67620controlled carbohydrate content diet (69 %) (for 91 days)controlled fat content diet (12 %) (for 91 days)controlled protein content diet (19 %) (for 91 days)
8heart weight to tibia length ratioSS/HsdMcwiCrlmale0.32g/cmcontrolled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days)67621controlled carbohydrate content diet (69 %) (for 63 days)controlled fat content diet (12 %) (for 63 days)controlled protein content diet (19 %) (for 63 days)controlled carbohydrate content diet (53 %) (for 28 days)controlled fat content diet (14 %) (for 28 days)controlled protein content diet (33 %) (for 28 days)
7both kidneys wet weight to tibia length ratioSS/HsdMcwiCrlmale0.81g/cmcontrolled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) then controlled protein content diet (33 %) (for 91 days)67639controlled carbohydrate content diet (53 %) (for 91 days)controlled fat content diet (14 %) (for 91 days)controlled protein content diet (33 %) (for 91 days)
9both kidneys wet weight to tibia length ratioSS/HsdMcwiCrlmale0.73g/cmcontrolled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days)67641controlled carbohydrate content diet (53 %) (for 63 days)controlled fat content diet (14 %) (for 63 days)controlled protein content diet (33 %) (for 63 days)controlled carbohydrate content diet (69 %) (for 28 days)controlled fat content diet (12 %) (for 28 days)controlled protein content diet (19 %) (for 28 days)
6both kidneys wet weight to tibia length ratioSS/HsdMcwiCrlmale0.71g/cmcontrolled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) then controlled protein content diet (19 %) (for 91 days)67642controlled carbohydrate content diet (69 %) (for 91 days)controlled fat content diet (12 %) (for 91 days)controlled protein content diet (19 %) (for 91 days)
8both kidneys wet weight to tibia length ratioSS/HsdMcwiCrlmale0.75g/cmcontrolled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days)67643controlled carbohydrate content diet (69 %) (for 63 days)controlled fat content diet (12 %) (for 63 days)controlled protein content diet (19 %) (for 63 days)controlled carbohydrate content diet (53 %) (for 28 days)controlled fat content diet (14 %) (for 28 days)controlled protein content diet (33 %) (for 28 days)
7epididymal fat pad weight to tibia length ratioSS/HsdMcwiCrlmale1.17g/cmcontrolled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days)67652controlled carbohydrate content diet (53 %) (for 91 days)controlled fat content diet (14 %) (for 91 days)controlled protein content diet (33 %) (for 91 days)
9epididymal fat pad weight to tibia length ratioSS/HsdMcwiCrlmale1.33g/cmcontrolled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days)67653controlled carbohydrate content diet (53 %) (for 63 days)controlled fat content diet (14 %) (for 63 days)controlled protein content diet (33 %) (for 63 days)controlled carbohydrate content diet (69 %) (for 28 days)controlled fat content diet (12 %) (for 28 days)controlled protein content diet (19 %) (for 28 days)
6epididymal fat pad weight to tibia length ratioSS/HsdMcwiCrlmale1.21g/cmcontrolled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days)67654controlled carbohydrate content diet (69 %) (for 91 days)controlled fat content diet (12 %) (for 91 days)controlled protein content diet (19 %) (for 91 days)
8epididymal fat pad weight to tibia length ratioSS/HsdMcwiCrlmale1.21g/cmcontrolled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days)67655controlled carbohydrate content diet (69 %) (for 63 days)controlled fat content diet (12 %) (for 63 days)controlled protein content diet (19 %) (for 63 days)controlled carbohydrate content diet (53 %) (for 28 days)controlled fat content diet (14 %) (for 28 days)controlled protein content diet (33 %) (for 28 days)
8food intake weight to body weight ratioSS/HsdMcwiCrlmale5.2g/d/100garterial catheter implantation (for 1 days)107145arterial catheter implantation (for 1 days)
8water intake drink rate to body weight ratioSS/HsdMcwiCrlmale0.33ml/d/kgarterial catheter implantation (for 1 days)107161arterial catheter implantation (for 1 days)
8volume of blood removed to total prehemorrhagic blood volume ratioSS/HsdMcwiCrlmale56.5%arterial catheter implantation (for 1 days) then controlled hemorrhage (between 1 and 6 hours)109130arterial catheter implantation (for 1 days)controlled hemorrhage (between 1 and 6 hours)
8absolute change in hematocritSS/HsdMcwiCrlmale11%arterial catheter implantation (for 1 days) then controlled hemorrhage (between 1 and 6 hours)107272arterial catheter implantation (for 1 days)controlled hemorrhage (between 1 and 6 hours)

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