F344-Nrg1Tn(sb-T2/Bart3)2.183Mcwi |
acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled sodium content diet (4 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70 days-84 days |
5 |
65.0 |
% |
9.2 |
20.58 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
62652 |
528 |
F344-Nrg1Tn(sb-T2/Bart3)2.183Mcwi |
maximum contractile force per wet weight of aorta |
controlled sodium content diet (4 %) (for 14 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
female |
70 days-84 days |
5 |
1.22 |
g/mg |
0.1 |
0.23 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
63189 |
528 |
F344-Nrg1Tn(sb-T2/Bart3)2.183Mcwi |
concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) |
controlled sodium content diet (4 %) (for 14 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
male |
70 days-84 days |
5 |
0.01 |
umol/l |
0.0 |
0.0 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
62799 |
528 |
F344-Nrg1Tn(sb-T2/Bart3)2.183Mcwi |
concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) |
controlled sodium content diet (4 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70 days-84 days |
5 |
1.75 |
E-7mole |
0.29 |
0.64 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
63050 |
528 |
F344-Nrg1Tn(sb-T2/Bart3)2.183Mcwi |
acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled sodium content diet (4 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70 days-84 days |
5 |
64.8 |
% |
4.87 |
10.9 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
62650 |
528 |
F344-Nrg1Tn(sb-T2/Bart3)2.183Mcwi |
logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) |
controlled sodium content diet (4 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70 days-84 days |
5 |
-6.85 |
null |
0.1 |
0.23 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
62875 |
528 |
F344-Nrg1Tn(sb-T2/Bart3)2.183Mcwi |
logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) |
controlled sodium content diet (4 %) (for 14 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
male |
70 days-84 days |
5 |
-8.21 |
null |
0.12 |
0.26 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
EC50 value is moles/liter |
63122 |
528 |
F344-Nrg1Tn(sb-T2/Bart3)2.183Mcwi |
concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) |
controlled sodium content diet (4 %) (for 14 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
female |
70 days-84 days |
5 |
0.01 |
umol/l |
0.0 |
0.0 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
62797 |
528 |
F344-Nrg1Tn(sb-T2/Bart3)2.183Mcwi |
logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) |
controlled sodium content diet (4 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70 days-84 days |
5 |
-6.78 |
null |
0.08 |
0.18 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
62873 |
528 |
F344-Nrg1Tn(sb-T2/Bart3)2.183Mcwi |
logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) |
controlled sodium content diet (4 %) (for 14 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
female |
70 days-84 days |
5 |
-8.03 |
null |
0.07 |
0.16 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
EC50 value is moles/liter |
63120 |
528 |
F344-Nrg1Tn(sb-T2/Bart3)2.183Mcwi |
maximum contractile force per wet weight of aorta |
controlled sodium content diet (4 %) (for 14 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
male |
70 days-84 days |
5 |
1.17 |
g/mg |
0.09 |
0.2 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
63191 |
528 |
F344-Nrg1Tn(sb-T2/Bart3)2.183Mcwi |
concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) |
controlled sodium content diet (4 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70 days-84 days |
5 |
1.6 |
E-7mole |
0.37 |
0.82 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
63052 |
528 |