10 | plasma insulin level | WKY/NHsd | female | 20 | mU/l | fasting (for 16 hours) then glucose solution (2 g/kg) | 11614 | fasting (for 16 hours) | glucose solution (2 g/kg) | |

10 | plasma insulin level | WKY/NHsd | male | 64.1 | mU/l | fasting (for 16 hours) then glucose solution (2 g/kg) | 11612 | fasting (for 16 hours) | glucose solution (2 g/kg) | |

15 | serum thyroid stimulating hormone level | WKY/NHsd | female | 3 | ng/ml | naive control condition | 67898 | naive control condition | | |

16 | serum thyroid stimulating hormone level | WKY/NHsd | male | 5.28 | ng/ml | naive control condition | 67897 | naive control condition | | |

8 | plasma creatinine level | WKY/NHsd | male | 0.31787282 | mg/dl | controlled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then sunitinib (7 mg/kg/d) (for 8 days) | 99174 | controlled sodium content diet (8 %) (for 8 days) | 0.9% sodium chloride solution (0.9 %) (for 8 days) | sunitinib (7 mg/kg/d) (for 8 days) |

7 | plasma creatinine level | WKY/NHsd | male | 0.30090452 | mg/dl | controlled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) | 99173 | controlled sodium content diet (8 %) (for 8 days) | 0.9% sodium chloride solution (0.9 %) (for 8 days) | vehicle control condition (0.5 ml) (for 8 days) |

8 | plasma creatinine level | WKY/NHsd | male | 0.35180942 | mg/dl | standard rat chow (for 8 days) then sunitinib (7 mg/kg/d) (for 8 days) | 99172 | standard rat chow (for 8 days) | sunitinib (7 mg/kg/d) (for 8 days) | |

7 | plasma creatinine level | WKY/NHsd | male | 0.30882306 | mg/dl | standard rat chow (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) | 99171 | standard rat chow (for 8 days) | vehicle control condition (0.5 ml) (for 8 days) | |

17 | mammary tumor number | WKY/NHsd | female | 0 | | 7,12-dimethyltetraphene (DMBA) (65 mg/kg) | 11741 | 7,12-dimethyltetraphene (DMBA) (65 mg/kg) | | |

8 | mean arterial blood pressure | WKY/NHsd | male | 124 | mmHg | controlled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then sunitinib (7 mg/kg/d) (for 8 days) | 99190 | controlled sodium content diet (8 %) (for 8 days) | 0.9% sodium chloride solution (0.9 %) (for 8 days) | sunitinib (7 mg/kg/d) (for 8 days) |

7 | mean arterial blood pressure | WKY/NHsd | male | 116 | mmHg | controlled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) | 99189 | controlled sodium content diet (8 %) (for 8 days) | 0.9% sodium chloride solution (0.9 %) (for 8 days) | vehicle control condition (0.5 ml) (for 8 days) |

8 | mean arterial blood pressure | WKY/NHsd | male | 128 | mmHg | standard rat chow (for 8 days) then sunitinib (7 mg/kg/d) (for 8 days) | 99188 | standard rat chow (for 8 days) | sunitinib (7 mg/kg/d) (for 8 days) | |

7 | mean arterial blood pressure | WKY/NHsd | male | 101 | mmHg | standard rat chow (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) | 99187 | standard rat chow (for 8 days) | vehicle control condition (0.5 ml) (for 8 days) | |

7 | plasma chloride level | WKY/NHsd | male | 104.8 | mmol/l | controlled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) | 99169 | controlled sodium content diet (8 %) (for 8 days) | 0.9% sodium chloride solution (0.9 %) (for 8 days) | vehicle control condition (0.5 ml) (for 8 days) |

8 | plasma chloride level | WKY/NHsd | male | 109.1 | mmol/l | controlled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then sunitinib (7 mg/kg/d) (for 8 days) | 99170 | controlled sodium content diet (8 %) (for 8 days) | 0.9% sodium chloride solution (0.9 %) (for 8 days) | sunitinib (7 mg/kg/d) (for 8 days) |

8 | plasma chloride level | WKY/NHsd | male | 100.5 | mmol/l | standard rat chow (for 8 days) then sunitinib (7 mg/kg/d) (for 8 days) | 99168 | standard rat chow (for 8 days) | sunitinib (7 mg/kg/d) (for 8 days) | |

7 | plasma chloride level | WKY/NHsd | male | 98.2 | mmol/l | standard rat chow (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) | 99167 | standard rat chow (for 8 days) | vehicle control condition (0.5 ml) (for 8 days) | |

20 | both adrenal glands wet weight | WKY/NHsd | female | 65.8 | mg | naive control condition | 11602 | naive control condition | | |

24 | both adrenal glands wet weight | WKY/NHsd | male | 43 | mg | naive control condition | 11600 | naive control condition | | |

10 | plasma glucose level | WKY/NHsd | female | 84.3 | mg/dl | fasting (for 16 hours) then glucose solution (2 g/kg) | 13184 | fasting (for 16 hours) | glucose solution (2 g/kg) | |

10 | plasma glucose level | WKY/NHsd | female | 163.7 | mg/dl | fasting (for 16 hours) then glucose solution (2 g/kg) | 13183 | fasting (for 16 hours) | glucose solution (2 g/kg) | |

10 | plasma glucose level | WKY/NHsd | female | 151.6 | mg/dl | physical restraint in tube type rodent restrainer (for 0.5 hours) | 13182 | physical restraint in tube type rodent restrainer (for 0.5 hours) | | |

10 | plasma glucose level | WKY/NHsd | male | 153.5 | mg/dl | physical restraint in tube type rodent restrainer (for 0.5 hours) | 13175 | physical restraint in tube type rodent restrainer (for 0.5 hours) | | |

10 | plasma glucose level | WKY/NHsd | male | 98.1 | mg/dl | fasting (for 16 hours) then glucose solution (2 g/kg) | 13174 | fasting (for 16 hours) | glucose solution (2 g/kg) | |

10 | plasma glucose level | WKY/NHsd | male | 173.8 | mg/dl | fasting (for 16 hours) then glucose solution (2 g/kg) | 13173 | fasting (for 16 hours) | glucose solution (2 g/kg) | |

8 | plasma sodium level | WKY/NHsd | male | 139.4 | mmol/l | controlled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then sunitinib (7 mg/kg/d) (for 8 days) | 99162 | controlled sodium content diet (8 %) (for 8 days) | 0.9% sodium chloride solution (0.9 %) (for 8 days) | sunitinib (7 mg/kg/d) (for 8 days) |

7 | plasma sodium level | WKY/NHsd | male | 141.4 | mmol/l | controlled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) | 99161 | controlled sodium content diet (8 %) (for 8 days) | 0.9% sodium chloride solution (0.9 %) (for 8 days) | vehicle control condition (0.5 ml) (for 8 days) |

8 | plasma sodium level | WKY/NHsd | male | 137.8 | mmol/l | standard rat chow (for 8 days) then sunitinib (7 mg/kg/d) (for 8 days) | 99160 | standard rat chow (for 8 days) | sunitinib (7 mg/kg/d) (for 8 days) | |

7 | plasma sodium level | WKY/NHsd | male | 143.7 | mmol/l | standard rat chow (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) | 99159 | standard rat chow (for 8 days) | vehicle control condition (0.5 ml) (for 8 days) | |

8 | creatinine clearance | WKY/NHsd | male | 3.5 | ml/min | controlled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then sunitinib (7 mg/kg/d) (for 8 days) | 99182 | controlled sodium content diet (8 %) (for 8 days) | 0.9% sodium chloride solution (0.9 %) (for 8 days) | sunitinib (7 mg/kg/d) (for 8 days) |

7 | creatinine clearance | WKY/NHsd | male | 3.5 | ml/min | controlled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) | 99181 | controlled sodium content diet (8 %) (for 8 days) | 0.9% sodium chloride solution (0.9 %) (for 8 days) | vehicle control condition (0.5 ml) (for 8 days) |

8 | creatinine clearance | WKY/NHsd | male | 3.1 | ml/min | standard rat chow (for 8 days) then sunitinib (7 mg/kg/d) (for 8 days) | 99180 | standard rat chow (for 8 days) | sunitinib (7 mg/kg/d) (for 8 days) | |

7 | creatinine clearance | WKY/NHsd | male | 3.1 | ml/min | standard rat chow (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) | 99179 | standard rat chow (for 8 days) | vehicle control condition (0.5 ml) (for 8 days) | |

8 | plasma potassium level | WKY/NHsd | male | 4.4 | mmol/l | controlled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then sunitinib (7 mg/kg/d) (for 8 days) | 99166 | controlled sodium content diet (8 %) (for 8 days) | 0.9% sodium chloride solution (0.9 %) (for 8 days) | sunitinib (7 mg/kg/d) (for 8 days) |

7 | plasma potassium level | WKY/NHsd | male | 4.2 | mmol/l | controlled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) | 99165 | controlled sodium content diet (8 %) (for 8 days) | 0.9% sodium chloride solution (0.9 %) (for 8 days) | vehicle control condition (0.5 ml) (for 8 days) |

8 | plasma potassium level | WKY/NHsd | male | 4.2 | mmol/l | standard rat chow (for 8 days) then sunitinib (7 mg/kg/d) (for 8 days) | 99164 | standard rat chow (for 8 days) | sunitinib (7 mg/kg/d) (for 8 days) | |

7 | plasma potassium level | WKY/NHsd | male | 3.9 | mmol/l | standard rat chow (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) | 99163 | standard rat chow (for 8 days) | vehicle control condition (0.5 ml) (for 8 days) | |

10 | body weight | WKY/NHsd | female | 230 | g | fasting (for 16 hours) | 11610 | fasting (for 16 hours) | | |

10 | body weight | WKY/NHsd | male | 352 | g | fasting (for 16 hours) | 11608 | fasting (for 16 hours) | | |

22 | number of entries into a discrete space in an experimental apparatus | WKY/NHsd | female | 6.2 | | naive control condition | 75706 | naive control condition | | |

28 | number of entries into a discrete space in an experimental apparatus | WKY/NHsd | male | 4 | | naive control condition | 75704 | naive control condition | | |

20 | plasma corticosterone level | WKY/NHsd | female | 584.5 | ng/ml | physical restraint (for 0.2 hours) | 13128 | physical restraint (for 0.2 hours) | | |

24 | plasma corticosterone level | WKY/NHsd | male | 287.5 | ng/ml | physical restraint (for 0.2 hours) | 13124 | physical restraint (for 0.2 hours) | | |

20 | plasma corticosterone level | WKY/NHsd | female | 113 | ng/ml | naive control condition | 13121 | naive control condition | | |

24 | plasma corticosterone level | WKY/NHsd | male | 31.7 | ng/ml | naive control condition | 13118 | naive control condition | | |

26 | duration of grooming in an experimental apparatus | WKY/NHsd | male | 82.4 | s | naive control condition | 75702 | naive control condition | | |

16 | duration of grooming in an experimental apparatus | WKY/NHsd | female | 97.9 | s | naive control condition | 75700 | naive control condition | | |

22 | duration of grooming in an experimental apparatus | WKY/NHsd | female | 42.5 | s | naive control condition | 75696 | naive control condition | | |

28 | duration of grooming in an experimental apparatus | WKY/NHsd | male | 35.3 | s | naive control condition | 68654 | naive control condition | | |

22 | number of rearing movements in an experimental apparatus | WKY/NHsd | female | 20.5 | | naive control condition | 75692 | naive control condition | | |

28 | number of rearing movements in an experimental apparatus | WKY/NHsd | male | 9.6 | | naive control condition | 75698 | naive control condition | | |

26 | number of rearing movements in an experimental apparatus | WKY/NHsd | male | 17.8 | | naive control condition | 75694 | naive control condition | | |

16 | number of rearing movements in an experimental apparatus | WKY/NHsd | female | 33.8 | | naive control condition | 68652 | naive control condition | | |

8 | skin potassium level to skin water level ratio | WKY/NHsd | male | 69 | mmol/l | controlled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then sunitinib (7 mg/kg/d) (for 8 days) | 99158 | controlled sodium content diet (8 %) (for 8 days) | 0.9% sodium chloride solution (0.9 %) (for 8 days) | sunitinib (7 mg/kg/d) (for 8 days) |

7 | skin potassium level to skin water level ratio | WKY/NHsd | male | 71 | mmol/l | controlled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) | 99157 | controlled sodium content diet (8 %) (for 8 days) | 0.9% sodium chloride solution (0.9 %) (for 8 days) | vehicle control condition (0.5 ml) (for 8 days) |

8 | skin potassium level to skin water level ratio | WKY/NHsd | male | 75 | mmol/l | standard rat chow (for 8 days) then sunitinib (7 mg/kg/d) (for 8 days) | 99156 | standard rat chow (for 8 days) | sunitinib (7 mg/kg/d) (for 8 days) | |

7 | skin potassium level to skin water level ratio | WKY/NHsd | male | 80 | mmol/l | standard rat chow (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) | 99155 | standard rat chow (for 8 days) | vehicle control condition (0.5 ml) (for 8 days) | |

8 | skin potassium level plus skin sodium level to skin water level ratio | WKY/NHsd | male | 0.171 | | controlled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then sunitinib (7 mg/kg/d) (for 8 days) | 99146 | controlled sodium content diet (8 %) (for 8 days) | 0.9% sodium chloride solution (0.9 %) (for 8 days) | sunitinib (7 mg/kg/d) (for 8 days) |

7 | skin potassium level plus skin sodium level to skin water level ratio | WKY/NHsd | male | 0.176 | | controlled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) | 99145 | controlled sodium content diet (8 %) (for 8 days) | 0.9% sodium chloride solution (0.9 %) (for 8 days) | vehicle control condition (0.5 ml) (for 8 days) |

8 | skin potassium level plus skin sodium level to skin water level ratio | WKY/NHsd | male | 0.167 | | standard rat chow (for 8 days) then sunitinib (7 mg/kg/d) (for 8 days) | 99144 | standard rat chow (for 8 days) | sunitinib (7 mg/kg/d) (for 8 days) | |

7 | skin potassium level plus skin sodium level to skin water level ratio | WKY/NHsd | male | 0.17 | | standard rat chow (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) | 99143 | standard rat chow (for 8 days) | vehicle control condition (0.5 ml) (for 8 days) | |

8 | plasma cystatin C level | WKY/NHsd | male | 3.9 | mg/l | controlled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then sunitinib (7 mg/kg/d) (for 8 days) | 99178 | controlled sodium content diet (8 %) (for 8 days) | 0.9% sodium chloride solution (0.9 %) (for 8 days) | sunitinib (7 mg/kg/d) (for 8 days) |

7 | plasma cystatin C level | WKY/NHsd | male | 3.5 | mg/l | controlled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) | 99177 | controlled sodium content diet (8 %) (for 8 days) | 0.9% sodium chloride solution (0.9 %) (for 8 days) | vehicle control condition (0.5 ml) (for 8 days) |

8 | plasma cystatin C level | WKY/NHsd | male | 4.7 | mg/l | standard rat chow (for 8 days) then sunitinib (7 mg/kg/d) (for 8 days) | 99176 | standard rat chow (for 8 days) | sunitinib (7 mg/kg/d) (for 8 days) | |

7 | plasma cystatin C level | WKY/NHsd | male | 4 | mg/l | standard rat chow (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) | 99175 | standard rat chow (for 8 days) | vehicle control condition (0.5 ml) (for 8 days) | |

8 | urine sodium excretion rate | WKY/NHsd | male | 34.3 | mEq/d | controlled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then sunitinib (7 mg/kg/d) (for 8 days) | 99186 | controlled sodium content diet (8 %) (for 8 days) | 0.9% sodium chloride solution (0.9 %) (for 8 days) | sunitinib (7 mg/kg/d) (for 8 days) |

7 | urine sodium excretion rate | WKY/NHsd | male | 41.9 | mEq/d | controlled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) | 99185 | controlled sodium content diet (8 %) (for 8 days) | 0.9% sodium chloride solution (0.9 %) (for 8 days) | vehicle control condition (0.5 ml) (for 8 days) |

8 | urine sodium excretion rate | WKY/NHsd | male | 1.1 | mEq/d | standard rat chow (for 8 days) then sunitinib (7 mg/kg/d) (for 8 days) | 99184 | standard rat chow (for 8 days) | sunitinib (7 mg/kg/d) (for 8 days) | |

7 | urine sodium excretion rate | WKY/NHsd | male | 1 | mEq/d | standard rat chow (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) | 99183 | standard rat chow (for 8 days) | vehicle control condition (0.5 ml) (for 8 days) | |

8 | skin water level to skin dry weight ratio | WKY/NHsd | male | 1.522 | ml/g | controlled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then sunitinib (7 mg/kg/d) (for 8 days) | 99142 | controlled sodium content diet (8 %) (for 8 days) | 0.9% sodium chloride solution (0.9 %) (for 8 days) | sunitinib (7 mg/kg/d) (for 8 days) |

7 | skin water level to skin dry weight ratio | WKY/NHsd | male | 1.432 | ml/g | controlled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) | 99141 | controlled sodium content diet (8 %) (for 8 days) | 0.9% sodium chloride solution (0.9 %) (for 8 days) | vehicle control condition (0.5 ml) (for 8 days) |

8 | skin water level to skin dry weight ratio | WKY/NHsd | male | 1.208 | ml/g | standard rat chow (for 8 days) then sunitinib (7 mg/kg/d) (for 8 days) | 99140 | standard rat chow (for 8 days) | sunitinib (7 mg/kg/d) (for 8 days) | |

7 | skin water level to skin dry weight ratio | WKY/NHsd | male | 1.223 | ml/g | standard rat chow (for 8 days) then sunitinib (0.5 ml) (for 8 days) | 99139 | standard rat chow (for 8 days) | sunitinib (0.5 ml) (for 8 days) | |

8 | skin sodium level to skin dry weight ratio | WKY/NHsd | male | 0.164 | REQUEST NEW VALUE | controlled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then sunitinib (7 mg/kg/d) (for 8 days) | 99134 | controlled sodium content diet (8 %) (for 8 days) | 0.9% sodium chloride solution (0.9 %) (for 8 days) | sunitinib (7 mg/kg/d) (for 8 days) |

7 | skin sodium level to skin dry weight ratio | WKY/NHsd | male | 0.144 | REQUEST NEW VALUE | controlled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) | 99133 | controlled sodium content diet (8 %) (for 8 days) | 0.9% sodium chloride solution (0.9 %) (for 8 days) | vehicle control condition (0.5 ml) (for 8 days) |

8 | skin sodium level to skin dry weight ratio | WKY/NHsd | male | 0.112 | REQUEST NEW VALUE | standard rat chow (for 8 days) then sunitinib (7 mg/kg/d) (for 8 days) | 99132 | standard rat chow (for 8 days) | sunitinib (7 mg/kg/d) (for 8 days) | |

7 | skin sodium level to skin dry weight ratio | WKY/NHsd | male | 0.11 | REQUEST NEW VALUE | standard rat chow (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) | 99131 | standard rat chow (for 8 days) | vehicle control condition (0.5 ml) (for 8 days) | |

8 | skin chloride level to skin dry weight ratio | WKY/NHsd | male | 0.073 | mmol/g | controlled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then sunitinib (7 mg/kg/d) (for 8 days) | 99138 | controlled sodium content diet (8 %) (for 8 days) | 0.9% sodium chloride solution (0.9 %) (for 8 days) | sunitinib (7 mg/kg/d) (for 8 days) |

7 | skin chloride level to skin dry weight ratio | WKY/NHsd | male | 0.068 | mmol/g | controlled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) | 99137 | controlled sodium content diet (8 %) (for 8 days) | 0.9% sodium chloride solution (0.9 %) (for 8 days) | vehicle control condition (0.5 ml) (for 8 days) |

8 | skin chloride level to skin dry weight ratio | WKY/NHsd | male | 0.052 | mmol/g | standard rat chow (for 8 days) then sunitinib (7 mg/kg/d) (for 8 days) | 99136 | standard rat chow (for 8 days) | sunitinib (7 mg/kg/d) (for 8 days) | |

7 | skin chloride level to skin dry weight ratio | WKY/NHsd | male | 0.051 | mmol/g | standard rat chow (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) | 99135 | standard rat chow (for 8 days) | vehicle control condition (0.5 ml) (for 8 days) | |

8 | skin chloride level to skin water level ratio | WKY/NHsd | male | 50 | mmol/l | controlled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then sunitinib (7 mg/kg/d) (for 8 days) | 99154 | controlled sodium content diet (8 %) (for 8 days) | 0.9% sodium chloride solution (0.9 %) (for 8 days) | sunitinib (7 mg/kg/d) (for 8 days) |

7 | skin chloride level to skin water level ratio | WKY/NHsd | male | 48 | mmol/l | controlled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) | 99153 | controlled sodium content diet (8 %) (for 8 days) | 0.9% sodium chloride solution (0.9 %) (for 8 days) | vehicle control condition (0.5 ml) (for 8 days) |

8 | skin chloride level to skin water level ratio | WKY/NHsd | male | 43 | mmol/l | standard rat chow (for 8 days) then sunitinib (7 mg/kg/d) (for 8 days) | 99152 | standard rat chow (for 8 days) | sunitinib (7 mg/kg/d) (for 8 days) | |

7 | skin chloride level to skin water level ratio | WKY/NHsd | male | 42 | mmol/l | standard rat chow (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) | 99151 | standard rat chow (for 8 days) | vehicle control condition (0.5 ml) (for 8 days) | |

8 | skin chloride level to skin water level ratio | WKY/NHsd | male | 108 | mmol/l | controlled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then sunitinib (7 mg/kg/d) (for 8 days) | 99150 | controlled sodium content diet (8 %) (for 8 days) | 0.9% sodium chloride solution (0.9 %) (for 8 days) | sunitinib (7 mg/kg/d) (for 8 days) |

7 | skin chloride level to skin water level ratio | WKY/NHsd | male | 101 | mmol/l | controlled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) | 99149 | controlled sodium content diet (8 %) (for 8 days) | 0.9% sodium chloride solution (0.9 %) (for 8 days) | vehicle control condition (0.5 ml) (for 8 days) |

8 | skin chloride level to skin water level ratio | WKY/NHsd | male | 92 | mmol/l | standard rat chow (for 8 days) then sunitinib (7 mg/kg/d) (for 8 days) | 99148 | standard rat chow (for 8 days) | sunitinib (7 mg/kg/d) (for 8 days) | |

7 | skin chloride level to skin water level ratio | WKY/NHsd | male | 90 | mmol/l | standard rat chow (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) | 99147 | standard rat chow (for 8 days) | vehicle control condition (0.5 ml) (for 8 days) | |