SS.MNS-(D2Mit6-D2Rat303)/Ayd |
mean arterial blood pressure |
controlled sodium content diet (2 %) (between 21 and 37 days) |
Dutil J, et al., Hypertension 2005 Apr;45(4):557-64. Epub 2005 Feb 28. |
arterial blood pressure trait |
male |
56 days-72 days |
9 |
168.0 |
mmHg |
4.0 |
12.0 |
intra-aortic abdominal radiotelemetry |
|
|
0 |
|
none |
12325 |
242 |
SS.MNS-(D2Mit6-D2Rat303)/Ayd |
logarithm of the concentration of angiotensin II at which the force of blood vessel contraction is half the maximum value (Log EC50) |
Kreb's solution perfusate then angiotensin II (0.3-300 umol/l) |
Dutil J, et al., Physiol Genomics 2005 Mar 1;. |
vasoconstriction trait |
male |
98 days
| 13 |
-7.86 |
null |
0.27 |
0.97 |
tissue force analysis utilizing a force transducer |
|
0.0 |
0 |
isometric force transducer |
|
69068 |
1096 |
SS.MNS-(D2Mit6-D2Rat303)/Ayd |
blood vessel contractile force measurement |
Kreb's solution perfusate then potassium chloride solution (40 mmol/l) |
Dutil J, et al., Physiol Genomics 2005 Mar 1;. |
vasoconstriction trait |
male |
98 days
| 13 |
1.62 |
g |
0.09 |
0.32 |
tissue force analysis utilizing a force transducer |
|
0.0 |
0 |
isometric force transducer |
|
69049 |
1096 |
SS.MNS-(D2Mit6-D2Rat303)/Ayd |
receptor-dependent blood vessel maximum contractile force to receptor-independent blood vessel maximum contractile force ratio |
Kreb's solution perfusate then phenylephrine (1-100 mmol/l) |
Dutil J, et al., Physiol Genomics 2005 Mar 1;. |
vasoconstriction trait |
male |
98 days
| 13 |
100.16 |
% |
5.63 |
20.3 |
tissue force analysis utilizing a force transducer |
|
0.0 |
0 |
isometric force transducer |
|
69053 |
1096 |
SS.MNS-(D2Mit6-D2Rat303)/Ayd |
receptor-dependent blood vessel maximum contractile force to receptor-independent blood vessel maximum contractile force ratio |
Kreb's solution perfusate then angiotensin II (0.3-300 umol/l) and NG-nitroarginine methyl ester (100 umol/l) |
Dutil J, et al., Physiol Genomics 2005 Mar 1;. |
vasoconstriction trait |
male |
98 days
| 13 |
26.63 |
% |
4.0 |
14.42 |
tissue force analysis utilizing a force transducer |
|
0.0 |
0 |
isometric force transducer |
|
69070 |
1096 |
SS.MNS-(D2Mit6-D2Rat303)/Ayd |
mean arterial blood pressure |
controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 10 and 24 days) |
Chauvet C, et al., Hum Mol Genet. 2013 Nov 15;22(22):4451-9. doi: 10.1093/hmg/ddt294. Epub 2013 Jun 28. |
arterial blood pressure trait |
male |
66 days-80 days |
8 |
167.0 |
mmHg |
|
|
intra-aortic abdominal radiotelemetry |
abdominal aorta |
0.0 |
0 |
|
|
70475 |
1438 |
SS.MNS-(D2Mit6-D2Rat303)/Ayd |
heart left ventricle deoxyribonucleic acid content to body weight ratio |
controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (for 63 days) |
Dutil J, et al., Physiol Genomics 2005 Mar 1;. |
heart left ventricle DNA amount |
male |
98 days
| 5 |
5.0 |
ug/g |
0.5 |
1.12 |
spectrophotometry |
|
0.0 |
0 |
|
|
69037 |
1096 |
SS.MNS-(D2Mit6-D2Rat303)/Ayd |
blood vessel contractile force measurement |
Kreb's solution perfusate then potassium chloride solution (40 mmol/l) and NG-nitroarginine methyl ester (100 umol/l) |
Dutil J, et al., Physiol Genomics 2005 Mar 1;. |
vasoconstriction trait |
male |
98 days
| 13 |
1.6 |
g |
0.12 |
0.43 |
tissue force analysis utilizing a force transducer |
|
0.0 |
0 |
isometric force transducer |
|
69051 |
1096 |
SS.MNS-(D2Mit6-D2Rat303)/Ayd |
receptor-dependent blood vessel maximum contractile force to receptor-independent blood vessel maximum contractile force ratio |
Kreb's solution perfusate then phenylephrine (1-100 mmol/l) and NG-nitroarginine methyl ester (100 umol/l) |
Dutil J, et al., Physiol Genomics 2005 Mar 1;. |
vasoconstriction trait |
male |
98 days
| 13 |
143.03 |
% |
6.62 |
23.87 |
tissue force analysis utilizing a force transducer |
|
0.0 |
0 |
isometric force transducer |
|
69057 |
1096 |
SS.MNS-(D2Mit6-D2Rat303)/Ayd |
aorta smooth muscle cell count per unit vessel length |
controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (for 63 days) |
Dutil J, et al., Physiol Genomics 2005 Mar 1;. |
blood vessel smooth muscle cell quantity |
male |
98 days
| 8 |
134.0 |
/um |
21.0 |
59.4 |
ex vivo light microscopy with digital image analysis |
|
0.0 |
0 |
|
/um - calculated aortic smooth muscle cell count |
69032 |
1096 |
SS.MNS-(D2Mit6-D2Rat303)/Ayd |
receptor-dependent blood vessel maximum contractile force to receptor-independent blood vessel maximum contractile force ratio |
Kreb's solution perfusate then angiotensin II (0.3-300 umol/l) |
Dutil J, et al., Physiol Genomics 2005 Mar 1;. |
vasoconstriction trait |
male |
98 days
| 13 |
19.33 |
% |
3.67 |
13.23 |
tissue force analysis utilizing a force transducer |
|
0.0 |
0 |
isometric force transducer |
|
69066 |
1096 |
SS.MNS-(D2Mit6-D2Rat303)/Ayd |
heart right ventricle deoxyribonucleic acid content to body weight ratio |
controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (for 63 days) |
Dutil J, et al., Physiol Genomics 2005 Mar 1;. |
heart right ventricle DNA amount |
male |
98 days
| 5 |
1.2 |
ug/g |
0.09 |
0.2 |
spectrophotometry |
|
0.0 |
0 |
|
|
69042 |
1096 |
SS.MNS-(D2Mit6-D2Rat303)/Ayd |
logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) |
Kreb's solution perfusate then phenylephrine (1-100 mmol/l) |
Dutil J, et al., Physiol Genomics 2005 Mar 1;. |
vasoconstriction trait |
male |
98 days
| 13 |
-6.96 |
null |
0.17 |
0.61 |
tissue force analysis utilizing a force transducer |
|
0.0 |
0 |
isometric force transducer |
EC50 value is probably moles/liter |
69055 |
1096 |
SS.MNS-(D2Mit6-D2Rat303)/Ayd |
mean arterial blood pressure |
controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (for 63 days) |
Dutil J, et al., Physiol Genomics 2005 Mar 1;. |
arterial blood pressure trait |
male |
68 days-98 days |
9 |
168.0 |
mmHg |
|
|
radiotelemetry |
|
0.0 |
0 |
|
|
69028 |
1096 |
SS.MNS-(D2Mit6-D2Rat303)/Ayd |
logarithm of the concentration of angiotensin II at which the force of blood vessel contraction is half the maximum value (Log EC50) |
Kreb's solution perfusate then angiotensin II (0.3-300 umol/l) and NG-nitroarginine methyl ester (100 umol/l) |
Dutil J, et al., Physiol Genomics 2005 Mar 1;. |
vasoconstriction trait |
male |
98 days
| 13 |
-7.2 |
null |
0.31 |
1.12 |
tissue force analysis utilizing a force transducer |
|
0.0 |
0 |
isometric force transducer |
|
69072 |
1096 |
SS.MNS-(D2Mit6-D2Rat303)/Ayd |
logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) |
Kreb's solution perfusate then phenylephrine (1-100 mmol/l) and NG-nitroarginine methyl ester (100 umol/l) |
Dutil J, et al., Physiol Genomics 2005 Mar 1;. |
vasoconstriction trait |
male |
98 days
| 13 |
-7.41 |
null |
0.16 |
0.58 |
tissue force analysis utilizing a force transducer |
|
0.0 |
0 |
isometric force transducer |
EC50 value is probably moles/liter |
69059 |
1096 |