Phenominer Database Results (232 results)

 
 
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Strain Phenotype Conditions Study Experiment Name Sex Age # of Animals Formula Value Units SEM SD Method Method Duration Post Insult Time Value Method Notes Clinical Measurement Notes Experiment Notes Record ID Study ID
SS-Chr YBN/Mcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 19 0.36 ml 0.01 0.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15464 381
SS-Chr YBN/Mcwi partial pressure of blood carbon dioxide (Pco2) resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 16 32.41 mmHg 0.41 1.65 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 14466 381
SS-Chr YBN/Mcwi mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 16 120.47 mmHg 3.7 14.82 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 19888 381
SS-Chr YBN/Mcwi heart rate control condition PhysGen Respiratory data heart pumping trait male 82 days-99 days 18 406.55 beats/min 10.33 43.82 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 20944 381
SS-Chr YBN/Mcwi body temperature resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 16 37.87 degrees C 0.12 0.49 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 18127 381
SS-Chr YBN/Mcwi serum total protein level control condition (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 20 6.18 g/dl 0.04 0.17 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37244 401
SS-Chr YBN/Mcwi mean corpuscular hemoglobin concentration control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 20 32.62 g/dl 0.06 0.26 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 37374 401
SS-Chr YBN/Mcwi serum calcium level control condition (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 20 8.97 mg/dl 0.11 0.49 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36805 401
SS-Chr YBN/Mcwi percent change in ventilation controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 19 %change=VE during 2-3 min hypercapnia/control during standard conditions 318.46 % 10.4 45.34 stop flow air displacement plethysmography 0 0 Moms and pups used in studies were fed Teklad 19278 381
SS-Chr YBN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 19 49.58 ml/min 1.8 7.86 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20275 381
SS-Chr YBN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 15 57.2 mmHg 1.03 3.99 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20498 381
SS-Chr YBN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 19 95.21 U/l 6.42 27.99 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42836 401
SS-Chr YBN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 20 0.34 mg/dl 0.02 0.08 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39642 401
SS-Chr YBN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 20 0.42 x 1000 cells/ul 0.06 0.27 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39740 401
SS-Chr YBN/Mcwi percent change in tidal volume controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 19 175.6 % 4.6 20.03 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54490 381
SS-Chr YBN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 20 2.63 g/dl 0.03 0.12 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40616 401
SS-Chr YBN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 17 2.21 mg/kg 0.37 1.52 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59210 526
SS-Chr YBN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 20 8.78 mg/dl 0.26 1.17 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37660 401
SS-Chr YBN/Mcwi serum urea nitrogen level control condition (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77 days-91 days 20 16.6 mg/dl 0.48 2.16 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41798 401
SS-Chr YBN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount male 77 days-91 days 20 157.2 mg/dl 3.24 14.48 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38596 401
SS-Chr YBN/Mcwi mean corpuscular volume control condition (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 20 56.56 fl 0.18 0.78 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38693 401
SS-Chr YBN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 19 9.81 ml/min/kg 0.43 1.87 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57664 526
SS-Chr YBN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 19 34.36 ml/min/kg 2.19 9.52 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58065 526
SS-Chr YBN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 17 0.03 umol/l 0.01 0.02 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54711 522
SS-Chr YBN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 20 0.05 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58555 526
SS-Chr YBN/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 18 46.06 % 2.66 11.3 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56284 522
SS-Chr YBN/Mcwi sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 20 99.65 % 0.18 0.81 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56316 522
SS-Chr YBN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass male 77 days-91 days 20 0.37 null 0.01 0.05 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58799 526
SS-Chr YBN/Mcwi sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 18 99.78 % 0.13 0.55 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56477 522
SS-Chr YBN/Mcwi heart contraction pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 26 57.31 mmHg 2.73 13.93 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48099 461
SS-Chr YBN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 24 6.19 ml/min/g 0.31 1.5 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46267 461
SS-Chr YBN/Mcwi minute ventilation controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 19 99.22 ml/min 3.46 15.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20828 381
SS-Chr YBN/Mcwi blood pH control condition PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 13 7.47 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20646 381
SS-Chr YBN/Mcwi mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 18 124.0 mmHg 2.7 11.43 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 15115 381
SS-Chr YBN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 18 413.66 beats/min 11.85 50.27 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17526 381
SS-Chr YBN/Mcwi tidal volume controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 19 0.63 ml 0.02 0.1 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 17437 381
SS-Chr YBN/Mcwi blood eosinophil count control condition (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77 days-91 days 20 0.0 x 1000 cells/ul 0.0 0.02 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41450 401
SS-Chr YBN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 29 1174.9 s 31.95 172.08 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50292 461
SS-Chr YBN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 25 post-ischemic value/pre-ischemic value x 100% 68.76 % 3.78 18.92 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48821 461
SS-Chr YBN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 17 -7.58 null 0.08 0.32 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 55312 522
SS-Chr YBN/Mcwi serum globulin level control condition (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 20 2.39 g/dl 0.03 0.14 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 41073 401
SS-Chr YBN/Mcwi heart rate control condition PhysGen Respiratory data heart pumping trait male 82 days-99 days 16 432.09 beats/min 17.32 69.29 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 15950 381
SS-Chr YBN/Mcwi absolute change in body temperature resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 16 0.6 degrees C 0.1 0.42 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16004 381
SS-Chr YBN/Mcwi urine total protein excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data total urine protein amount male 80 days-99 days 17 152.58 mg/d 15.5 63.93 automated urine total protein analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52708 482
SS-Chr YBN/Mcwi heart rate controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 16 402.09 beats/min 17.32 69.29 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14720 381
SS-Chr YBN/Mcwi partial pressure of blood carbon dioxide (Pco2) resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 13 29.61 mmHg 0.44 1.59 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 13429 381
SS-Chr YBN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 15 7.51 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17071 381
SS-Chr YBN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 13 0.05 null 0.0 0.01 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19807 381
SS-Chr YBN/Mcwi absolute change in partial pressure of blood carbon dioxide resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 13 -2.88 mmHg 0.42 1.52 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20083 381
SS-Chr YBN/Mcwi blood pH resting on treadmill (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 16 7.47 null 0.0 0.02 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 20155 381
SS-Chr YBN/Mcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 19 0.38 ml 0.02 0.09 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18049 381
SS-Chr YBN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 20 60.27 fl 0.52 2.33 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38811 401
SS-Chr YBN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 20 61.58 % 0.71 3.18 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39057 401
SS-Chr YBN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 19 144.74 mmol/l 0.43 1.88 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39454 401
SS-Chr YBN/Mcwi serum chloride level control condition (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 20 103.95 mmol/l 0.39 1.76 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40052 401
SS-Chr YBN/Mcwi mean corpuscular hemoglobin control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 20 18.45 pg 0.07 0.31 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40244 401
SS-Chr YBN/Mcwi serum albumin level control condition (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 20 3.79 g/dl 0.03 0.15 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40453 401
SS-Chr YBN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 20 0.11 mg/dl 0.01 0.03 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41934 401
SS-Chr YBN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 29 0.36 IU/g 0.03 0.18 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47480 461
SS-Chr YBN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 28 235.7 beats/min 6.26 33.1 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47647 461
SS-Chr YBN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 19 132.35 mmHg 5.04 21.96 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48689 461
SS-Chr YBN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 18 39.67 % 3.71 15.74 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57261 522
SS-Chr YBN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 19 12.64 ml/min/kg 0.53 2.29 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57866 526
SS-Chr YBN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 19 38.0 degrees C 0.12 0.5 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16639 381
SS-Chr YBN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 18 -7.21 null 0.03 0.12 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55662 522
SS-Chr YBN/Mcwi concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 18 0.05 10E-7mol/l 0.01 0.02 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55747 522
SS-Chr YBN/Mcwi body temperature control condition PhysGen Respiratory data body temperature trait male 82 days-99 days 19 37.81 degrees C 0.13 0.55 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16879 381
SS-Chr YBN/Mcwi FAPGG metabolism-surface area product FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 19 36.68 ml/min/kg 1.92 8.38 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58272 526
SS-Chr YBN/Mcwi logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 20 -8.7 null 0.08 0.35 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56029 522
SS-Chr YBN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 18 50.67 % 2.85 12.08 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54817 522
SS-Chr YBN/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 19 45.47 % 4.11 17.91 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55084 522
SS-Chr YBN/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 15 66.2 % 3.66 14.18 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57180 522
SS-Chr YBN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 28 11.9 ml/min/g 0.51 2.72 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46718 461
SS-Chr YBN/Mcwi left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 24 55.14 mmHg 2.34 11.48 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47767 461
SS-Chr YBN/Mcwi heart weight to body weight ratio control condition PhysGen Cardiac data heart mass male 49 days-63 days 26 4.59 g/kg 0.08 0.43 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 47028 461
SS-Chr YBN/Mcwi percent change in heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 26 post-ischemic value/pre-ischemic value x 100% 84.2 % 8.13 41.48 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48472 461
SS-Chr YBN/Mcwi absolute change in mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 10 14.02 mmHg 2.07 6.54 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 20727 381
SS-Chr YBN/Mcwi urine sodium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine sodium amount male 80 days-99 days 17 13.93 mEq/d 1.18 4.86 flame atomic emission spectrometry 0 Moms were fed Teklad, pups used in studies were fed Dyets 52759 482
SS-Chr YBN/Mcwi percent change in tidal volume controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 19 172.54 % 3.59 15.65 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54150 381
SS-Chr YBN/Mcwi absolute change in heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 10 heart rate during walking-heart rate during rest 69.33 beats/min 9.08 28.7 vascular fluid filled catheter 0 0 Moms and pups used in studies were fed Teklad 13395 381
SS-Chr YBN/Mcwi mean arterial blood pressure controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 16 122.07 mmHg 3.36 13.43 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 13507 381
SS-Chr YBN/Mcwi respiration rate control condition PhysGen Respiratory data respiratory function trait male 82 days-99 days 19 98.6 breaths/min 4.76 20.75 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18477 381
SS-Chr YBN/Mcwi heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 10 470.17 beats/min 11.18 35.35 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 13798 381
SS-Chr YBN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 19 0.43 ml 0.02 0.08 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13990 381
SS-Chr YBN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine albumin amount male 80 days-99 days 17 43.12 mg/d 6.07 25.03 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52608 482
SS-Chr YBN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 26 0.27 IU/g 0.03 0.17 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47344 461
SS-Chr YBN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 28 203.53 beats/min 7.7 40.73 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45213 461
SS-Chr YBN/Mcwi body weight control condition PhysGen Cardiac data body mass male 49 days-63 days 26 228.1 g 5.7 29.0 whole body digital scale 0 Moms and pups used in studies were fed Teklad 47850 461
SS-Chr YBN/Mcwi left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 24 108.39 mmHg 4.05 19.82 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 44881 461
SS-Chr YBN/Mcwi serum bicarbonate level control condition (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 20 22.7 mmol/l 0.37 1.66 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 43036 401
SS-Chr YBN/Mcwi body weight control condition (for 14 days) PhysGen Lung data body mass male 77 days-91 days 20 281.9 g 3.2 14.1 whole body digital scale 0 Moms and pups used in studies were fed Teklad 58384 526
SS-Chr YBN/Mcwi percent change in respiration rate controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 19 184.97 % 5.14 22.41 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53699 381
SS-Chr YBN/Mcwi respiration rate control condition PhysGen Respiratory data respiratory function trait male 82 days-99 days 19 87.93 breaths/min 3.02 13.16 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15002 381
SS-Chr YBN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 19 0.42 ml 0.02 0.08 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15300 381
SS-Chr YBN/Mcwi minute ventilation controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 19 98.93 ml/min 3.68 16.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14567 381
SS-Chr YBN/Mcwi creatinine clearance controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data glomerular filtration trait male 80 days-99 days 12 2.76 ml/min 0.28 0.96 urine creatinine analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52169 482
SS-Chr YBN/Mcwi heart rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data heart pumping trait male 80 days-99 days 15 387.26 beats/min 8.89 34.45 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52659 482
SS-Chr YBN/Mcwi absolute change in blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 13 -0.01 null 0.01 0.03 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14760 381
SS-Chr YBN/Mcwi percent change in ventilation controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 19 %change=VE during7-9 min hypercapnia/control during standard conditions 320.75 % 12.08 52.64 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14265 381
SS-Chr YBN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 19 52.58 ml/min 1.95 8.5 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18729 381
SS-Chr YBN/Mcwi partial pressure of blood oxygen control condition PhysGen Respiratory data blood oxygen amount male 82 days-99 days 13 107.63 mmHg 1.94 6.98 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 18890 381
SS-Chr YBN/Mcwi mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 10 136.73 mmHg 2.58 8.17 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 18942 381
SS-Chr YBN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 20 6.43 g/dl 0.05 0.21 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37028 401
SS-Chr YBN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 19 0.19 degrees C 0.16 0.71 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20376 381
SS-Chr YBN/Mcwi heart wet weight control condition PhysGen Cardiac data heart mass male 49 days-63 days 26 1.04 g 0.03 0.14 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49126 461
SS-Chr YBN/Mcwi left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 19 5.54 mmHg 0.15 0.66 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49243 461
SS-Chr YBN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 20 19.51 pg 0.06 0.27 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42611 401
SS-Chr YBN/Mcwi total white blood cell count control condition (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 20 6.43 x 1000 cells/ul 0.43 1.91 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39931 401
SS-Chr YBN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 20 58.15 U/l 3.46 15.46 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40780 401
SS-Chr YBN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77 days-91 days 20 61.58 % 0.71 3.18 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59323 526
SS-Chr YBN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77 days-91 days 20 22.85 mg/dl 0.67 3.0 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40894 401
SS-Chr YBN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 20 7.26 x 1000 cells/ul 0.35 1.55 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40992 401
SS-Chr YBN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 17 5.05 mmol/l 0.07 0.27 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38132 401
SS-Chr YBN/Mcwi serum total cholesterol level control condition (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 20 87.7 mg/dl 1.66 7.42 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38479 401
SS-Chr YBN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77 days-91 days 20 0.02 x 1000 cells/ul 0.01 0.04 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41713 401
SS-Chr YBN/Mcwi absolute change in partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 13 14.04 mmHg 2.44 8.8 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16286 381
SS-Chr YBN/Mcwi tidal volume controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 19 0.62 ml 0.02 0.09 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16540 381
SS-Chr YBN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 18 0.39 null 0.03 0.11 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58179 526
SS-Chr YBN/Mcwi logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 18 -8.3 null 0.05 0.2 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54621 522
SS-Chr YBN/Mcwi methylene blue metabolism-surface area product without auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 19 14.24 ml/min/kg 0.76 3.29 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58669 526
SS-Chr YBN/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 15 42.6 % 4.34 16.83 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55057 522
SS-Chr YBN/Mcwi calculated pulmonary vascular resistance normalized to body weight Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 19 0.14 mmHg x min x kg x ml-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59934 526
SS-Chr YBN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 18 -6.98 null 0.04 0.19 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56952 522
SS-Chr YBN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 26 9.97 ml/min/g 0.36 1.85 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46935 461
SS-Chr YBN/Mcwi left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 24 53.26 mmHg 4.13 20.23 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47977 461
SS-Chr YBN/Mcwi body temperature resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 16 38.47 degrees C 0.11 0.44 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 17643 381
SS-Chr YBN/Mcwi body weight control condition PhysGen Respiratory data body mass male 82 days-99 days 24 325.6 g 4.0 19.7 whole body digital scale 0 Moms and pups used in studies were fed Dyets 17884 381
SS-Chr YBN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 19 %change=VE during 2-3 min hypoxia/control during standard conditions 145.58 % 4.29 18.7 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13747 381
SS-Chr YBN/Mcwi percent change in left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 16 post-ischemic value/pre-ischemic value x 100% 84.98 % 7.21 28.83 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 44984 461
SS-Chr YBN/Mcwi percent change in left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 12 post-ischemic value/pre-ischemic value x 100% 43.46 % 5.88 20.38 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46385 461
SS-Chr YBN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 24 139.37 mmHg 4.46 21.86 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45794 461
SS-Chr YBN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 29 5.8 ml/min/g 0.47 2.53 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44783 461
SS-Chr YBN/Mcwi plasma creatinine level control condition (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 20 0.25 mg/dl 0.01 0.05 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 42692 401
SS-Chr YBN/Mcwi maximum contractile force per wet weight of aorta potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 20 1.37 g/mg 0.1 0.44 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55825 522
SS-Chr YBN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 29 907.97 s 40.12 216.05 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49364 461
SS-Chr YBN/Mcwi plasma anion gap control condition (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 20 22.7 mmol/l 0.39 1.75 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 43177 401
SS-Chr YBN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 28 94.9 mmHg 3.01 15.95 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49953 461
SS-Chr YBN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 29 45.52 mmHg 2.58 13.88 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50062 461
SS-Chr YBN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 24 post-ischemic value/pre-ischemic value x 100% 31.94 % 3.61 17.69 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48592 461
SS-Chr YBN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 18 1.14 E-7mole 0.12 0.52 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56557 522
SS-Chr YBN/Mcwi hematocrit control condition (for 14 days) PhysGen Lung data erythrocyte quantity male 77 days-91 days 20 45.72 % 0.4 1.77 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 57533 526
SS-Chr YBN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data renin activity male 80 days-99 days 12 0.26 ng/ml/h 0.02 0.06 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52463 482
SS-Chr YBN/Mcwi body temperature controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 19 37.64 degrees C 0.15 0.64 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 13626 381
SS-Chr YBN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 18 121.57 mmHg 3.51 14.91 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14353 381
SS-Chr YBN/Mcwi respiration rate controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 19 158.68 breaths/min 3.52 15.36 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 17178 381
SS-Chr YBN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount male 82 days-99 days 15 26.5 mmHg 0.57 2.22 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17263 381
SS-Chr YBN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 19 114.04 % 3.14 13.67 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53950 381
SS-Chr YBN/Mcwi mean arterial blood pressure resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 16 120.73 mmHg 1.48 5.93 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 20049 381
SS-Chr YBN/Mcwi heart rate resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 16 399.56 beats/min 4.57 18.27 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17741 381
SS-Chr YBN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 19 124.91 breaths/min 4.36 19.02 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18332 381
SS-Chr YBN/Mcwi blood lymphocyte count control condition (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 20 5.52 x 1000 cells/ul 0.41 1.82 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 36915 401
SS-Chr YBN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 20 88.25 mg/dl 1.93 8.62 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37163 401
SS-Chr YBN/Mcwi serum sodium level control condition (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 20 144.0 mmol/l 0.27 1.21 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36536 401
SS-Chr YBN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 25 17.28 % 2.63 13.15 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49462 461
SS-Chr YBN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 20 3.81 g/dl 0.03 0.15 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42299 401
SS-Chr YBN/Mcwi serum aspartate aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 19 86.68 U/l 4.34 18.92 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42463 401
SS-Chr YBN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 19 128.31 % 3.17 13.82 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54391 381
SS-Chr YBN/Mcwi blood hemoglobin level control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 20 14.92 g/dl 0.13 0.56 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40148 401
SS-Chr YBN/Mcwi blood monocyte count control condition (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 20 0.19 x 1000 cells/ul 0.03 0.15 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40340 401
SS-Chr YBN/Mcwi lung dry weight to body weight ratio control condition (for 14 days) PhysGen Lung data lung mass male 77 days-91 days 20 0.83 g/kg 0.01 0.05 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59500 526
SS-Chr YBN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 20 0.15 mmHg x min x kg x ml-1 0.0 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59613 526
SS-Chr YBN/Mcwi serum glucose level control condition (for 14 days) PhysGen Biochemistry data blood glucose amount male 77 days-91 days 20 159.05 mg/dl 2.0 8.94 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41240 401
SS-Chr YBN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 20 5.77 x 1000 cells/ul 0.33 1.45 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41569 401
SS-Chr YBN/Mcwi red blood cell count control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 20 8.09 x 10E6 cells/ul 0.08 0.37 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42015 401
SS-Chr YBN/Mcwi maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 20 1.32 g/mg 0.09 0.39 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57371 522
SS-Chr YBN/Mcwi body weight control condition (for 21 days) PhysGen Vascular data body mass male 70 days-84 days 20 311.5 g 5.4 24.1 whole body digital scale 0 Moms and pups used in studies were fed Teklad 55451 522
SS-Chr YBN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 18 0.63 E-7mole 0.04 0.18 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55931 522
SS-Chr YBN/Mcwi concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 20 0.03 10E-7mol/l 0.01 0.03 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56241 522
SS-Chr YBN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 19 0.39 null 0.01 0.06 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 59818 526
SS-Chr YBN/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 17 57.24 % 2.01 8.29 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57147 522
SS-Chr YBN/Mcwi partial pressure of blood carbon dioxide (Pco2) control condition PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 13 31.27 mmHg 0.89 3.21 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 16090 381
SS-Chr YBN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 24 4.91 mmHg 0.22 1.1 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47262 461
SS-Chr YBN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 28 42.56 mmHg 4.23 22.39 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45335 461
SS-Chr YBN/Mcwi partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 13 113.33 mmHg 2.06 7.44 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 15045 381
SS-Chr YBN/Mcwi percent change in respiration rate controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 19 183.29 % 6.06 26.42 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54284 381
SS-Chr YBN/Mcwi absolute change in body temperature controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 19 0.23 degrees C 0.15 0.65 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 15736 381
SS-Chr YBN/Mcwi blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 13 7.46 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14599 381
SS-Chr YBN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 19 121.43 breaths/min 4.49 19.58 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14861 381
SS-Chr YBN/Mcwi urine potassium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine potassium amount male 80 days-99 days 17 1.4 mEq/d 0.1 0.4 flame atomic emission spectrometry 0 urine potassium analysis Moms were fed Teklad, pups used in studies were fed Dyets 52955 482
SS-Chr YBN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 30 5.82 g/kg 0.21 1.15 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45653 461
SS-Chr YBN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 20 25.75 mmol/l 0.51 2.27 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38327 401
SS-Chr YBN/Mcwi serum potassium level control condition (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 19 5.18 mmol/l 0.16 0.69 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 43373 401
SS-Chr YBN/Mcwi time to onset of heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 26 938.46 s 27.41 139.76 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50185 461
SS-Chr YBN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 17 1.56 mg/kg 0.23 0.96 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58972 526
SS-Chr YBN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 4 46.09 IU/g 4.96 9.92 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 48891 461
SS-Chr YBN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 19 0.05 mmHg-1 0.01 0.03 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59404 526
SS-Chr YBN/Mcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 19 31.45 ml/min 1.28 5.59 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16214 381
SS-Chr YBN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 20 19.79 g/dl 0.26 1.14 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38034 401
SS-Chr YBN/Mcwi hematocrit control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 20 45.72 % 0.4 1.77 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41348 401
SS-Chr YBN/Mcwi heart right ventricle weight to left ventricle weight ratio control condition (for 14 days) PhysGen Lung data heart right ventricle mass male 77 days-91 days 20 0.22 null 0.01 0.04 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 57947 526
SS-Chr YBN/Mcwi mean arterial blood pressure controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data arterial blood pressure trait male 80 days-99 days 15 163.31 mmHg 4.36 16.88 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52857 482
SS-Chr YBN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount male 80 days-99 days 12 0.31 mg/dl 0.02 0.07 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52218 482
SS-Chr YBN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 19 111.37 % 3.96 17.26 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54051 381
SS-Chr YBN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 19 125.33 % 4.4 19.16 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53818 381
SS-Chr YBN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 13 -4.81 mmHg 0.84 3.03 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19655 381
SS-Chr YBN/Mcwi respiration rate controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 19 161.0 breaths/min 4.37 19.05 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16978 381
SS-Chr YBN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 20 208.8 U/l 6.19 27.67 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36445 401
SS-Chr YBN/Mcwi percent change in ventilation controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 19 %change=VE during7-9 min hypercapnia/control during standard conditions 138.79 % 6.15 26.81 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18610 381
SS-Chr YBN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 20 9.58 mg/dl 0.08 0.37 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36690 401
SS-Chr YBN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 13 -50.18 mmHg 1.58 5.7 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19486 381
SS-Chr YBN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 29 14.73 % 2.34 12.61 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49763 461
SS-Chr YBN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 20 16.1 mmol/l 0.46 2.05 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42128 401
SS-Chr YBN/Mcwi blood neutrophil count control condition (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77 days-91 days 20 0.71 x 1000 cells/ul 0.06 0.25 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38942 401
SS-Chr YBN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 20 10.14 x 10E6 cells/ul 0.12 0.54 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39303 401
SS-Chr YBN/Mcwi serum total bilirubin level control condition (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 19 0.1 mg/dl 0.0 0.0 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42929 401
SS-Chr YBN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 20 32.12 g/dl 0.07 0.33 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39843 401
SS-Chr YBN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77 days-91 days 20 1.0 x 1000 cells/ul 0.09 0.38 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43290 401
SS-Chr YBN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass male 77 days-91 days 20 263.4 g 4.0 17.7 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59128 526
SS-Chr YBN/Mcwi serum alkaline phosphatase activity level control condition (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 20 182.75 U/l 7.89 35.29 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37496 401
SS-Chr YBN/Mcwi serum alanine aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 19 53.05 U/l 2.69 11.72 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37753 401
SS-Chr YBN/Mcwi serum phosphate level control condition (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 20 8.46 mg/dl 0.15 0.69 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37873 401
SS-Chr YBN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 30 0.97 g 0.03 0.18 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45470 461
SS-Chr YBN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 29 53.02 mmHg 2.78 14.97 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46482 461
SS-Chr YBN/Mcwi time to peak heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 26 1140.77 s 29.68 151.34 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46614 461
SS-Chr YBN/Mcwi body weight controlled sodium content diet (4 %) (for 21 days) PhysGen Vascular data body mass male 70 days-84 days 20 300.3 g 5.9 26.4 whole body digital scale 0 Moms and pups used in studies were fed Teklad 55216 522
SS-Chr YBN/Mcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 19 36.84 ml/min 1.9 8.29 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16757 381
SS-Chr YBN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 19 0.04 umol/l 0.0 0.02 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54943 522
SS-Chr YBN/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 15 35.07 % 4.24 16.43 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55145 522
SS-Chr YBN/Mcwi heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 26 248.32 beats/min 10.82 55.17 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48263 461
SS-Chr YBN/Mcwi body temperature control condition PhysGen Respiratory data body temperature trait male 82 days-99 days 19 37.41 degrees C 0.2 0.89 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 19136 381
SS-Chr YBN/Mcwi heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 24 216.67 beats/min 15.8 77.42 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49011 461
SS-Chr YBN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 29 post-ischemic value/pre-ischemic value x 100% 47.98 % 3.14 16.93 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47142 461
SS-Chr YBN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 29 post-ischemic value/pre-ischemic value x 100% 86.66 % 4.99 26.85 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48360 461
SS-Chr YBN/Mcwi left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 12 122.45 mmHg 5.02 17.4 balloon tipped catheter with pressure transducer in isolated perfused heart 0 46816 461
SS-Chr YBN/Mcwi percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 26 post-ischemic value/pre-ischemic value x 100% 57.77 % 4.58 23.34 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46131 461
SS-Chr YBN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass male 49 days-63 days 30 167.6 g 4.5 24.9 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49555 461
SS-Chr YBN/Mcwi left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 16 126.9 mmHg 4.85 19.4 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45570 461
SS-Chr YBN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 19 -7.47 null 0.05 0.24 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 56142 522
SS-Chr YBN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 20 107.95 mmol/l 0.47 2.11 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39183 401
SS-Chr YBN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass male 77 days-91 days 20 1.09 g/kg 0.01 0.05 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59723 526
SS-Chr YBN/Mcwi methylene blue metabolism-surface area product after auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 19 8.43 ml/min/kg 0.61 2.65 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 60040 526
SS-Chr YBN/Mcwi partial pressure of blood oxygen resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 16 100.31 mmHg 1.85 7.4 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 16400 381