Phenominer Database Results (466 results)

 

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Strain Phenotype Conditions Study Experiment Name Sex Age # of Animals Formula Value Units SEM SD Method Method Site Method Duration Post Insult Time Value Method Notes Clinical Measurement Notes Experiment Notes Record ID Study ID
SS-Chr 2BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 12 123.29 mmHg 4.45 15.41 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14378 381
SS-Chr 2BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data renin activity female 80 days-99 days 10 0.99 ng/ml/h 0.13 0.43 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52477 482
SS-Chr 2BN/Mcwi mean arterial blood pressure controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data arterial blood pressure trait male 80 days-99 days 9 174.74 mmHg 5.35 16.04 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52877 482
SS-Chr 2BN/Mcwi heart rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data heart pumping trait female 80 days-99 days 10 400.36 beats/min 6.22 19.67 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52673 482
SS-Chr 2BN/Mcwi urine sodium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine sodium amount female 80 days-99 days 10 12.32 mEq/d 1.69 5.33 flame atomic emission spectrometry 0 Moms were fed Teklad, pups used in studies were fed Dyets 52773 482
SS-Chr 2BN/Mcwi respiration rate controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 12 139.49 breaths/min 3.19 11.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 17138 381
SS-Chr 2BN/Mcwi body temperature controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 13 37.45 degrees C 0.11 0.39 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 13582 381
SS-Chr 2BN/Mcwi mean arterial blood pressure resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 12 120.37 mmHg 3.29 11.4 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 20062 381
SS-Chr 2BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 12 103.24 % 5.3 18.37 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54011 381
SS-Chr 2BN/Mcwi mean corpuscular hemoglobin concentration control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 9 32.36 g/dl 0.11 0.33 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 37396 401
SS-Chr 2BN/Mcwi serum calcium level control condition (for 14 days) PhysGen Biochemistry data blood calcium amount female 77 days-91 days 9 9.39 mg/dl 0.16 0.49 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36827 401
SS-Chr 2BN/Mcwi percent change in ventilation controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 13 %change=VE during7-9 min hypercapnia/control during standard conditions 126.32 % 4.88 17.61 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18570 381
SS-Chr 2BN/Mcwi body temperature control condition PhysGen Respiratory data body temperature trait male 82 days-99 days 12 37.04 degrees C 0.37 1.29 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 19096 381
SS-Chr 2BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 12 97.23 breaths/min 3.3 11.42 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18288 381
SS-Chr 2BN/Mcwi heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 15 188.63 beats/min 7.12 27.56 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48968 461
SS-Chr 2BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 9 56.06 mmHg 1.74 5.22 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20516 381
SS-Chr 2BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 10 58.0 mmHg 6.97 22.04 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50024 461
SS-Chr 2BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 15 58.69 % 0.92 3.58 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39018 401
SS-Chr 2BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 15 107.13 mmol/l 1.29 5.0 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39144 401
SS-Chr 2BN/Mcwi serum aspartate aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77 days-91 days 9 69.56 U/l 5.06 15.17 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42485 401
SS-Chr 2BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 15 79.0 U/l 3.91 15.13 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42797 401
SS-Chr 2BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount female 77 days-91 days 10 146.0 mmol/l 0.45 1.41 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39411 401
SS-Chr 2BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 13 118.05 % 5.02 18.1 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54354 381
SS-Chr 2BN/Mcwi mean corpuscular hemoglobin control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 6 18.9 pg 0.12 0.3 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40274 401
SS-Chr 2BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 11 1.73 mg/kg 0.14 0.46 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58933 526
SS-Chr 2BN/Mcwi serum albumin level control condition (for 14 days) PhysGen Biochemistry data blood albumin amount female 77 days-91 days 9 4.12 g/dl 0.07 0.2 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40475 401
SS-Chr 2BN/Mcwi serum albumin level control condition (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 6 3.95 g/dl 0.11 0.27 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40483 401
SS-Chr 2BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 15 52.33 U/l 2.24 8.66 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40741 401
SS-Chr 2BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77 days-91 days 10 5.11 x 1000 cells/ul 0.24 0.77 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40949 401
SS-Chr 2BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 15 8.82 mg/dl 0.14 0.54 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37621 401
SS-Chr 2BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 15 18.7 g/dl 0.28 1.09 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 37995 401
SS-Chr 2BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass female 77 days-91 days 10 1.46 g/kg 0.03 0.09 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59680 526
SS-Chr 2BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass male 77 days-91 days 16 1.18 g/kg 0.03 0.11 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59684 526
SS-Chr 2BN/Mcwi lung dry weight to body weight ratio control condition (for 14 days) PhysGen Lung data lung mass female 77 days-91 days 15 1.1 g/kg 0.04 0.15 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59522 526
SS-Chr 2BN/Mcwi serum urea nitrogen level control condition (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77 days-91 days 6 15.67 mg/dl 0.71 1.75 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41828 401
SS-Chr 2BN/Mcwi serum total cholesterol level control condition (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 6 81.83 mg/dl 3.32 8.13 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38509 401
SS-Chr 2BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 42.51 % 4.93 15.6 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48554 461
SS-Chr 2BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 15 0.1 mg/dl 0.0 0.0 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41895 401
SS-Chr 2BN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 14 -6.94 null 0.07 0.27 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55692 522
SS-Chr 2BN/Mcwi concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 12 0.05 10E-7mol/l 0.01 0.04 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55760 522
SS-Chr 2BN/Mcwi body temperature control condition PhysGen Respiratory data body temperature trait female 82 days-99 days 12 37.63 degrees C 0.21 0.72 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16835 381
SS-Chr 2BN/Mcwi body temperature control condition PhysGen Respiratory data body temperature trait male 82 days-99 days 13 37.34 degrees C 0.12 0.45 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16839 381
SS-Chr 2BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 16 0.37 null 0.03 0.12 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58140 526
SS-Chr 2BN/Mcwi logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 12 -8.47 null 0.11 0.37 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54634 522
SS-Chr 2BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 9 10.25 ml/min/kg 1.1 3.29 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58699 526
SS-Chr 2BN/Mcwi calculated pulmonary vascular resistance normalized to body weight Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 10 0.15 mmHg x min x kg x ml-1 0.01 0.04 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59964 526
SS-Chr 2BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 0.27 null 0.04 0.11 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 59840 526
SS-Chr 2BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 9 9.8 ml/min/kg 1.1 3.29 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 60070 526
SS-Chr 2BN/Mcwi tidal volume controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 12 0.54 ml 0.04 0.13 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 17397 381
SS-Chr 2BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 11.08 ml/min/g 0.8 2.52 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46897 461
SS-Chr 2BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 10 6.99 g/kg 0.1 0.33 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45675 461
SS-Chr 2BN/Mcwi heart weight to body weight ratio control condition PhysGen Cardiac data heart mass male 49 days-63 days 10 4.63 g/kg 0.18 0.58 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 47058 461
SS-Chr 2BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 12 33.55 ml/min 3.83 13.27 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20231 381
SS-Chr 2BN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 11 0.05 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19830 381
SS-Chr 2BN/Mcwi partial pressure of blood carbon dioxide (Pco2) resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 12 34.1 mmHg 0.57 1.96 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 14484 381
SS-Chr 2BN/Mcwi minute ventilation controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 12 83.97 ml/min 5.76 19.97 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14527 381
SS-Chr 2BN/Mcwi blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 11 7.45 null 0.01 0.04 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14612 381
SS-Chr 2BN/Mcwi serum total protein level control condition (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 6 6.2 g/dl 0.09 0.22 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37274 401
SS-Chr 2BN/Mcwi partial pressure of blood oxygen control condition PhysGen Respiratory data blood oxygen amount male 82 days-99 days 11 104.17 mmHg 1.23 4.07 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 18915 381
SS-Chr 2BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 13 0.47 ml 0.04 0.14 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13950 381
SS-Chr 2BN/Mcwi heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 201.9 beats/min 9.57 30.26 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48224 461
SS-Chr 2BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 198.22 beats/min 8.25 26.1 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45175 461
SS-Chr 2BN/Mcwi left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 46.47 mmHg 6.32 18.96 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47728 461
SS-Chr 2BN/Mcwi percent change in left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 77.62 % 9.37 29.62 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 44945 461
SS-Chr 2BN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 9 -7.3 null 0.07 0.22 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56980 522
SS-Chr 2BN/Mcwi plasma creatinine level control condition (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77 days-91 days 9 0.24 mg/dl 0.02 0.05 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 42714 401
SS-Chr 2BN/Mcwi blood eosinophil count control condition (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77 days-91 days 9 0.02 x 1000 cells/ul 0.02 0.05 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41472 401
SS-Chr 2BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77 days-91 days 10 0.28 mg/dl 0.03 0.09 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39599 401
SS-Chr 2BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 15 0.5 x 1000 cells/ul 0.06 0.24 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39701 401
SS-Chr 2BN/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 15 53.47 % 3.3 12.79 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57156 522
SS-Chr 2BN/Mcwi serum bicarbonate level control condition (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77 days-91 days 9 23.33 mmol/l 0.53 1.58 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 43058 401
SS-Chr 2BN/Mcwi maximum contractile force per wet weight of aorta potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 20 1.49 g/mg 0.15 0.66 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55847 522
SS-Chr 2BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount male 77 days-91 days 15 158.47 mg/dl 5.61 21.74 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38557 401
SS-Chr 2BN/Mcwi serum potassium level control condition (for 14 days) PhysGen Biochemistry data blood potassium amount female 77 days-91 days 9 4.02 mmol/l 0.13 0.39 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 43395 401
SS-Chr 2BN/Mcwi plasma anion gap control condition (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 6 23.83 mmol/l 0.65 1.6 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 43207 401
SS-Chr 2BN/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 16 35.5 % 3.44 13.78 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55069 522
SS-Chr 2BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77 days-91 days 10 0.04 mmHg-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59426 526
SS-Chr 2BN/Mcwi hematocrit control condition (for 14 days) PhysGen Lung data erythrocyte quantity male 77 days-91 days 8 45.44 % 0.56 1.58 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 57563 526
SS-Chr 2BN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 15 48.4 % 4.84 18.76 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57291 522
SS-Chr 2BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 19 -7.37 null 0.05 0.2 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 55334 522
SS-Chr 2BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 12 %change=VE during 2-3 min hypoxia/control during standard conditions 132.84 % 6.34 21.95 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13703 381
SS-Chr 2BN/Mcwi heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 9 494.15 beats/min 12.46 37.38 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 13816 381
SS-Chr 2BN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 9 7.53 null 0.01 0.04 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17088 381
SS-Chr 2BN/Mcwi heart rate control condition PhysGen Respiratory data heart pumping trait female 82 days-99 days 8 426.12 beats/min 15.9 44.97 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 15966 381
SS-Chr 2BN/Mcwi partial pressure of blood carbon dioxide (Pco2) resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 11 32.84 mmHg 0.63 2.08 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 14479 381
SS-Chr 2BN/Mcwi partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 11 112.37 mmHg 1.13 3.74 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 15058 381
SS-Chr 2BN/Mcwi urine potassium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine potassium amount female 80 days-99 days 10 0.91 mEq/d 0.08 0.25 flame atomic emission spectrometry 0 urine potassium analysis Moms were fed Teklad, pups used in studies were fed Dyets 52969 482
SS-Chr 2BN/Mcwi percent change in ventilation controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 12 %change=VE during7-9 min hypercapnia/control during standard conditions 247.55 % 11.75 40.7 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14225 381
SS-Chr 2BN/Mcwi mean arterial blood pressure resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 12 125.67 mmHg 3.56 12.34 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 20067 381
SS-Chr 2BN/Mcwi respiration rate controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 12 152.28 breaths/min 5.6 19.41 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16938 381
SS-Chr 2BN/Mcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 12 0.31 ml 0.02 0.08 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18005 381
SS-Chr 2BN/Mcwi blood lymphocyte count control condition (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77 days-91 days 9 4.83 x 1000 cells/ul 0.5 1.51 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 36937 401
SS-Chr 2BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 15 249.33 U/l 8.98 34.78 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36406 401
SS-Chr 2BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 15 6.51 g/dl 0.13 0.49 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36989 401
SS-Chr 2BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 10 412.88 beats/min 24.38 77.08 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17544 381
SS-Chr 2BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 12 35.35 ml/min 3.28 11.35 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18685 381
SS-Chr 2BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount female 77 days-91 days 10 9.01 mg/dl 0.11 0.34 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36647 401
SS-Chr 2BN/Mcwi serum sodium level control condition (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 6 147.33 mmol/l 0.33 0.82 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36566 401
SS-Chr 2BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 12 -0.53 degrees C 0.29 1.0 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20332 381
SS-Chr 2BN/Mcwi body temperature resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 12 37.47 degrees C 0.11 0.38 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 18145 381
SS-Chr 2BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 11 56.5 mmHg 1.41 4.69 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20523 381
SS-Chr 2BN/Mcwi blood pH resting on treadmill (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 11 7.46 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 20168 381
SS-Chr 2BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 10 44.4 mmHg 4.13 13.06 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50020 461
SS-Chr 2BN/Mcwi heart wet weight control condition PhysGen Cardiac data heart mass female 49 days-63 days 15 0.77 g 0.03 0.11 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49083 461
SS-Chr 2BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77 days-91 days 10 62.46 fl 0.45 1.41 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38768 401
SS-Chr 2BN/Mcwi blood neutrophil count control condition (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77 days-91 days 9 0.53 x 1000 cells/ul 0.12 0.36 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38964 401
SS-Chr 2BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 10 57.17 % 0.47 1.49 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39014 401
SS-Chr 2BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount female 77 days-91 days 10 4.08 g/dl 0.03 0.09 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42256 401
SS-Chr 2BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77 days-91 days 10 85.0 U/l 8.57 27.09 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42793 401
SS-Chr 2BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 15 9.31 x 10E6 cells/ul 0.15 0.57 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39264 401
SS-Chr 2BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77 days-91 days 10 0.46 x 1000 cells/ul 0.09 0.28 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43247 401
SS-Chr 2BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 12 115.71 % 6.49 22.49 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54351 381
SS-Chr 2BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass female 77 days-91 days 10 145.5 g 2.3 7.2 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59085 526
SS-Chr 2BN/Mcwi serum chloride level control condition (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 6 105.67 mmol/l 1.05 2.58 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40082 401
SS-Chr 2BN/Mcwi blood hemoglobin level control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 9 14.59 g/dl 0.25 0.75 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40170 401
SS-Chr 2BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 11 1.2 mg/kg 0.2 0.68 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59232 526
SS-Chr 2BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 10 1.67 mg/kg 0.37 1.18 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59240 526
SS-Chr 2BN/Mcwi serum glucose level control condition (for 14 days) PhysGen Biochemistry data blood glucose amount male 77 days-91 days 6 161.17 mg/dl 4.63 11.34 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41270 401
SS-Chr 2BN/Mcwi serum total cholesterol level control condition (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77 days-91 days 9 89.78 mg/dl 1.93 5.78 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38501 401
SS-Chr 2BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77 days-91 days 10 0.03 x 1000 cells/ul 0.01 0.04 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41670 401
SS-Chr 2BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 230.53 beats/min 8.76 27.71 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47609 461
SS-Chr 2BN/Mcwi time to peak heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 1233.9 s 62.94 199.04 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46575 461
SS-Chr 2BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 12.22 ml/min/kg 1.35 4.26 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57823 526
SS-Chr 2BN/Mcwi body weight controlled sodium content diet (4 %) (for 21 days) PhysGen Vascular data body mass male 70 days-84 days 10 277.2 g 3.2 10.0 whole body digital scale 0 Moms and pups used in studies were fed Teklad 55244 522
SS-Chr 2BN/Mcwi partial pressure of blood carbon dioxide (Pco2) control condition PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 11 32.3 mmHg 1.32 4.38 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 16115 381
SS-Chr 2BN/Mcwi hematocrit control condition (for 14 days) PhysGen Lung data erythrocyte quantity female 77 days-91 days 11 45.83 % 0.88 2.93 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 57555 526
SS-Chr 2BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 11.62 ml/min/kg 1.2 3.78 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57621 526
SS-Chr 2BN/Mcwi heart right ventricle weight to left ventricle weight ratio control condition (for 14 days) PhysGen Lung data heart right ventricle mass male 77 days-91 days 10 0.17 null 0.01 0.03 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 57977 526
SS-Chr 2BN/Mcwi body weight control condition (for 21 days) PhysGen Vascular data body mass female 70 days-84 days 20 175.6 g 3.2 14.3 whole body digital scale 0 Moms and pups used in studies were fed Teklad 55473 522
SS-Chr 2BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 50.41 ml/min/kg 4.22 13.34 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58022 526
SS-Chr 2BN/Mcwi partial pressure of blood oxygen resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 11 100.09 mmHg 1.26 4.17 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 16413 381
SS-Chr 2BN/Mcwi FAPGG metabolism-surface area product FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 78.53 ml/min/kg 7.76 24.53 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58294 526
SS-Chr 2BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 0.25 null 0.04 0.11 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58136 526
SS-Chr 2BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 18 0.06 umol/l 0.01 0.06 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54741 522
SS-Chr 2BN/Mcwi logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 10 -8.41 null 0.2 0.62 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56043 522
SS-Chr 2BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 16 0.03 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58516 526
SS-Chr 2BN/Mcwi logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 11 -8.57 null 0.09 0.3 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54629 522
SS-Chr 2BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 10 -7.52 null 0.1 0.32 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 56170 522
SS-Chr 2BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 9 0.24 null 0.02 0.06 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 59848 526
SS-Chr 2BN/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 16 24.63 % 2.27 9.09 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55152 522
SS-Chr 2BN/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 10 55.2 % 1.96 6.2 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57161 522
SS-Chr 2BN/Mcwi tidal volume controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 13 0.49 ml 0.05 0.19 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 17393 381
SS-Chr 2BN/Mcwi heart contraction pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 15 55.0 mmHg 4.11 15.93 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48056 461
SS-Chr 2BN/Mcwi heart contraction pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 10 65.2 mmHg 3.87 12.25 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48060 461
SS-Chr 2BN/Mcwi left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 117.18 mmHg 7.53 22.58 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 44842 461
SS-Chr 2BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 52.52 % 3.24 10.24 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47100 461
SS-Chr 2BN/Mcwi percent change in left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 14 post-ischemic value/pre-ischemic value x 100% 47.8 % 3.0 11.21 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46342 461
SS-Chr 2BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 52.88 % 4.88 15.43 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47104 461
SS-Chr 2BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 68.15 mmHg 11.65 36.84 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45297 461
SS-Chr 2BN/Mcwi renal afferent arteriole diameter controlled sodium chloride content diet (1 %) (between 70 and 91 days) then controlled ex vivo artery perfusion pressure (60 mmHg) (for 0.1 hours) Miller B, et al., J Clin Invest. 2016 Jul 1;126(7):2533-46. doi: 10.1172/JCI75079. Epub 2016 Jun 6. kidney arteriole morphology trait not specified 91 days-133 days 8 21.1 um 0.9 2.55 ex vivo videomicroscopy renal afferent arteriole 120.0 0 ex vivo videomicroscopy (MMO:0000319) renal afferent arteriole diameter (CMO:0003725) renal arteriole morphology trait 106495 3030
SS-Chr 2BN/Mcwi absolute change in mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 11 8.53 mmHg 2.1 6.96 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 20740 381
SS-Chr 2BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 13 117.6 % 4.88 17.61 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53913 381
SS-Chr 2BN/Mcwi body temperature resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 12 37.91 degrees C 0.19 0.67 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 17656 381
SS-Chr 2BN/Mcwi respiration rate controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 13 159.75 breaths/min 7.3 26.31 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16934 381
SS-Chr 2BN/Mcwi mean arterial blood pressure controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 9 126.07 mmHg 5.22 15.66 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 13523 381
SS-Chr 2BN/Mcwi percent change in ventilation controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 13 %change=VE during 2-3 min hypercapnia/control during standard conditions 319.79 % 19.68 70.96 stop flow air displacement plethysmography 0 0 Moms and pups used in studies were fed Teklad 19234 381
SS-Chr 2BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 12 104.14 breaths/min 6.17 21.36 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14817 381
SS-Chr 2BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount female 80 days-99 days 10 0.32 mg/dl 0.02 0.06 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52232 482
SS-Chr 2BN/Mcwi percent change in heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 15 post-ischemic value/pre-ischemic value x 100% 87.42 % 3.31 12.84 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48429 461
SS-Chr 2BN/Mcwi left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 15 48.69 mmHg 4.0 15.49 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47724 461
SS-Chr 2BN/Mcwi serum total bilirubin level control condition (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 6 0.1 mg/dl 0.0 0.0 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42959 401
SS-Chr 2BN/Mcwi serum bicarbonate level control condition (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 6 21.83 mmol/l 0.31 0.75 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 43066 401
SS-Chr 2BN/Mcwi body weight control condition (for 14 days) PhysGen Lung data body mass female 77 days-91 days 15 164.0 g 5.8 22.4 whole body digital scale 0 Moms and pups used in studies were fed Teklad 58406 526
SS-Chr 2BN/Mcwi body weight control condition (for 14 days) PhysGen Lung data body mass male 77 days-91 days 10 234.7 g 4.6 14.6 whole body digital scale 0 Moms and pups used in studies were fed Teklad 58414 526
SS-Chr 2BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 10 1.94 % 0.6 1.9 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49721 461
SS-Chr 2BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 117.19 mmHg 14.7 46.47 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49915 461
SS-Chr 2BN/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 15 36.0 % 4.72 18.29 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55093 522
SS-Chr 2BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity female 77 days-91 days 10 57.17 % 0.47 1.49 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59280 526
SS-Chr 2BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77 days-91 days 10 8.44 mg/dl 0.28 0.9 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37617 401
SS-Chr 2BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount female 77 days-91 days 10 4.29 mmol/l 0.08 0.26 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38089 401
SS-Chr 2BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 0.16 mmHg x min x kg x ml-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59570 526
SS-Chr 2BN/Mcwi hematocrit control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 9 45.14 % 0.86 2.57 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41370 401
SS-Chr 2BN/Mcwi hematocrit control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 6 45.25 % 0.68 1.66 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41378 401
SS-Chr 2BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 12 0.32 ml 0.03 0.09 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15256 381
SS-Chr 2BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 13 0.44 ml 0.02 0.09 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15260 381
SS-Chr 2BN/Mcwi percent change in tidal volume controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 12 171.84 % 4.45 15.42 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54113 381
SS-Chr 2BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 13 %change=VE during 2-3 min hypoxia/control during standard conditions 138.21 % 7.07 25.5 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13707 381
SS-Chr 2BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 10 121.23 mmHg 6.91 21.84 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14371 381
SS-Chr 2BN/Mcwi respiration rate controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 13 145.98 breaths/min 5.15 18.57 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 17134 381
SS-Chr 2BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 12 0.36 ml 0.03 0.1 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13946 381
SS-Chr 2BN/Mcwi mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 8 129.71 mmHg 6.29 17.78 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 19904 381
SS-Chr 2BN/Mcwi minute ventilation controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 12 74.67 ml/min 4.39 15.21 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20788 381
SS-Chr 2BN/Mcwi respiration rate control condition PhysGen Respiratory data respiratory function trait female 82 days-99 days 12 86.33 breaths/min 4.88 16.89 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18433 381
SS-Chr 2BN/Mcwi blood lymphocyte count control condition (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 6 4.76 x 1000 cells/ul 0.5 1.23 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 36945 401
SS-Chr 2BN/Mcwi partial pressure of blood oxygen control condition PhysGen Respiratory data blood oxygen amount female 82 days-99 days 9 104.08 mmHg 2.24 6.71 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 18908 381
SS-Chr 2BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 13 101.38 breaths/min 2.9 10.46 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14821 381
SS-Chr 2BN/Mcwi respiration rate control condition PhysGen Respiratory data respiratory function trait female 82 days-99 days 13 89.12 breaths/min 4.55 16.42 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14958 381
SS-Chr 2BN/Mcwi respiration rate control condition PhysGen Respiratory data respiratory function trait male 82 days-99 days 12 95.9 breaths/min 4.33 15.0 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14962 381
SS-Chr 2BN/Mcwi mean arterial blood pressure controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data arterial blood pressure trait female 80 days-99 days 10 150.38 mmHg 3.4 10.75 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52871 482
SS-Chr 2BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data renin activity male 80 days-99 days 9 0.58 ng/ml/h 0.1 0.29 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52483 482
SS-Chr 2BN/Mcwi heart rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data heart pumping trait male 80 days-99 days 9 397.25 beats/min 8.94 26.81 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52679 482
SS-Chr 2BN/Mcwi heart rate controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 8 371.2 beats/min 13.44 38.01 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14743 381
SS-Chr 2BN/Mcwi absolute change in blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 10 -0.01 null 0.01 0.02 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14773 381
SS-Chr 2BN/Mcwi absolute change in blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 12 -0.03 null 0.01 0.05 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14778 381
SS-Chr 2BN/Mcwi absolute change in heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 11 heart rate during walking-heart rate during rest 101.42 beats/min 7.49 24.86 vascular fluid filled catheter 0 0 Moms and pups used in studies were fed Teklad 13408 381
SS-Chr 2BN/Mcwi absolute change in heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 9 heart rate during walking-heart rate during rest 92.25 beats/min 11.0 33.01 vascular fluid filled catheter 0 0 Moms and pups used in studies were fed Teklad 13413 381
SS-Chr 2BN/Mcwi partial pressure of blood carbon dioxide (Pco2) resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 11 28.35 mmHg 0.76 2.52 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 13442 381
SS-Chr 2BN/Mcwi mean arterial blood pressure controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 8 125.46 mmHg 2.88 8.14 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 13530 381
SS-Chr 2BN/Mcwi body temperature resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 12 37.67 degrees C 0.16 0.55 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 17661 381
SS-Chr 2BN/Mcwi mean corpuscular hemoglobin concentration control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 6 32.32 g/dl 0.11 0.28 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 37404 401
SS-Chr 2BN/Mcwi percent change in ventilation controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 12 %change=VE during 2-3 min hypercapnia/control during standard conditions 275.87 % 12.33 42.7 stop flow air displacement plethysmography 0 0 Moms and pups used in studies were fed Teklad 19238 381
SS-Chr 2BN/Mcwi heart wet weight control condition PhysGen Cardiac data heart mass male 49 days-63 days 10 1.03 g 0.05 0.16 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49087 461
SS-Chr 2BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 13 103.16 breaths/min 2.39 8.63 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18292 381
SS-Chr 2BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 15 8.64 % 1.69 6.55 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49419 461
SS-Chr 2BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 8 7.03 % 2.54 7.19 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49423 461
SS-Chr 2BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass male 49 days-63 days 10 154.1 g 4.4 14.0 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49585 461
SS-Chr 2BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass female 49 days-63 days 10 131.0 g 2.0 6.3 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49577 461
SS-Chr 2BN/Mcwi time to onset of heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 10 998.7 s 52.91 167.32 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50146 461
SS-Chr 2BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 15 3.76 g/dl 0.04 0.14 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42260 401
SS-Chr 2BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 15 146.27 mmol/l 0.48 1.87 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39415 401
SS-Chr 2BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77 days-91 days 15 1.37 x 1000 cells/ul 0.2 0.76 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43251 401
SS-Chr 2BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass male 77 days-91 days 16 210.1 g 7.5 30.0 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59089 526
SS-Chr 2BN/Mcwi blood hemoglobin level control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 6 14.62 g/dl 0.2 0.49 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40178 401
SS-Chr 2BN/Mcwi serum chloride level control condition (for 14 days) PhysGen Biochemistry data blood chloride amount female 77 days-91 days 9 103.33 mmol/l 0.47 1.41 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40074 401
SS-Chr 2BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77 days-91 days 15 58.69 % 0.92 3.58 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59284 526
SS-Chr 2BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 9 5.27 mmol/l 0.22 0.65 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38093 401
SS-Chr 2BN/Mcwi serum glucose level control condition (for 14 days) PhysGen Biochemistry data blood glucose amount female 77 days-91 days 9 159.33 mg/dl 3.1 9.29 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41262 401
SS-Chr 2BN/Mcwi serum urea nitrogen level control condition (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77 days-91 days 9 17.78 mg/dl 1.4 4.21 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41820 401
SS-Chr 2BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 10 0.92 g 0.02 0.07 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45428 461
SS-Chr 2BN/Mcwi red blood cell count control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 9 7.81 x 10E6 cells/ul 0.16 0.49 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42037 401
SS-Chr 2BN/Mcwi red blood cell count control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 6 7.73 x 10E6 cells/ul 0.11 0.27 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42045 401
SS-Chr 2BN/Mcwi body weight controlled sodium content diet (4 %) (for 21 days) PhysGen Vascular data body mass female 70 days-84 days 16 193.0 g 2.5 9.9 whole body digital scale 0 Moms and pups used in studies were fed Teklad 55236 522
SS-Chr 2BN/Mcwi maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 10 1.05 g/mg 0.15 0.48 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57399 522
SS-Chr 2BN/Mcwi partial pressure of blood carbon dioxide (Pco2) control condition PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 9 33.23 mmHg 1.23 3.7 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 16108 381
SS-Chr 2BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 12 37.1 degrees C 0.27 0.93 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16595 381
SS-Chr 2BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 13 37.38 degrees C 0.12 0.42 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16599 381
SS-Chr 2BN/Mcwi body weight control condition (for 21 days) PhysGen Vascular data body mass male 70 days-84 days 19 287.1 g 6.1 26.6 whole body digital scale 0 Moms and pups used in studies were fed Teklad 55481 522
SS-Chr 2BN/Mcwi partial pressure of blood oxygen resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 12 100.9 mmHg 1.74 6.03 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 16418 381
SS-Chr 2BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 15 1.35 E-7mole 0.21 0.83 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55953 522
SS-Chr 2BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 14 1.35 E-7mole 0.2 0.76 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55961 522
SS-Chr 2BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 10 0.04 umol/l 0.01 0.03 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54971 522
SS-Chr 2BN/Mcwi concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 10 0.17 10E-7mol/l 0.14 0.43 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56255 522
SS-Chr 2BN/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 16 29.25 % 2.55 10.18 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55064 522
SS-Chr 2BN/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 10 16.4 % 0.97 3.06 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55098 522
SS-Chr 2BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 14 0.92 E-7mole 0.33 1.25 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56577 522
SS-Chr 2BN/Mcwi sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 10 90.7 % 3.32 10.5 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56330 522
SS-Chr 2BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass male 77 days-91 days 16 0.34 null 0.03 0.1 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58760 526
SS-Chr 2BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 16.45 ml/min/kg 1.26 3.99 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 60062 526
SS-Chr 2BN/Mcwi body weight control condition PhysGen Cardiac data body mass female 49 days-63 days 15 147.7 g 2.2 8.3 whole body digital scale 0 Moms and pups used in studies were fed Teklad 47872 461
SS-Chr 2BN/Mcwi body weight control condition PhysGen Cardiac data body mass male 49 days-63 days 10 222.4 g 4.9 15.6 whole body digital scale 0 Moms and pups used in studies were fed Teklad 47880 461
SS-Chr 2BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 158.91 mmHg 9.27 26.22 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45756 461
SS-Chr 2BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 14.1 ml/min/g 1.29 4.07 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46676 461
SS-Chr 2BN/Mcwi left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 134.01 mmHg 7.37 23.3 balloon tipped catheter with pressure transducer in isolated perfused heart 0 46773 461
SS-Chr 2BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 8 6.39 mmHg 0.15 0.44 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47220 461
SS-Chr 2BN/Mcwi heart weight to body weight ratio control condition PhysGen Cardiac data heart mass female 49 days-63 days 15 5.23 g/kg 0.16 0.62 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 47050 461
SS-Chr 2BN/Mcwi left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 15 59.16 mmHg 3.71 14.38 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47934 461
SS-Chr 2BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 83.27 % 4.0 12.65 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48318 461
SS-Chr 2BN/Mcwi minute ventilation controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 13 72.38 ml/min 7.79 28.07 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20784 381
SS-Chr 2BN/Mcwi left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 11 5.4 mmHg 0.39 1.3 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49200 461
SS-Chr 2BN/Mcwi absolute change in body temperature resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 12 0.52 degrees C 0.17 0.58 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16017 381
SS-Chr 2BN/Mcwi body temperature controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 12 36.96 degrees C 0.34 1.17 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 13586 381
SS-Chr 2BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount female 82 days-99 days 9 27.26 mmHg 1.04 3.12 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17281 381
SS-Chr 2BN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 11 7.5 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17094 381
SS-Chr 2BN/Mcwi heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 11 519.62 beats/min 6.89 22.84 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 13811 381
SS-Chr 2BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77 days-91 days 10 83.6 mg/dl 3.33 10.54 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37120 401
SS-Chr 2BN/Mcwi body temperature control condition PhysGen Respiratory data body temperature trait female 82 days-99 days 13 37.57 degrees C 0.12 0.45 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 19092 381
SS-Chr 2BN/Mcwi creatinine clearance controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data glomerular filtration trait male 80 days-99 days 9 2.27 ml/min 0.15 0.46 urine creatinine analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52189 482
SS-Chr 2BN/Mcwi serum calcium level control condition (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 6 9.22 mg/dl 0.12 0.29 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36835 401
SS-Chr 2BN/Mcwi percent change in heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 77.45 % 9.35 29.57 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48433 461
SS-Chr 2BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 10 174.67 beats/min 14.84 46.94 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45171 461
SS-Chr 2BN/Mcwi maximum contractile force per wet weight of aorta potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 19 1.02 g/mg 0.07 0.31 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55855 522
SS-Chr 2BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 10 846.4 s 64.88 205.18 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49322 461
SS-Chr 2BN/Mcwi left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 13 146.4 mmHg 9.44 34.03 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45527 461
SS-Chr 2BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77 days-91 days 10 48.8 U/l 3.92 12.38 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40737 401
SS-Chr 2BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 80.56 % 4.79 15.15 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48779 461
SS-Chr 2BN/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 15 34.6 % 4.62 17.89 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56293 522
SS-Chr 2BN/Mcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 13 24.72 ml/min 1.78 6.41 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16170 381
SS-Chr 2BN/Mcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 13 0.29 ml 0.03 0.1 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15420 381
SS-Chr 2BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount male 82 days-99 days 11 27.69 mmHg 1.06 3.5 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17288 381
SS-Chr 2BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 13 115.01 % 2.92 10.54 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53781 381
SS-Chr 2BN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 9 0.05 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19824 381
SS-Chr 2BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 13 110.22 % 4.16 15.01 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54014 381
SS-Chr 2BN/Mcwi heart rate control condition PhysGen Respiratory data heart pumping trait male 82 days-99 days 12 432.93 beats/min 14.79 51.24 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 20969 381
SS-Chr 2BN/Mcwi respiration rate control condition PhysGen Respiratory data respiratory function trait male 82 days-99 days 13 89.07 breaths/min 4.06 14.66 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18437 381
SS-Chr 2BN/Mcwi mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 9 141.27 mmHg 4.76 14.29 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 18960 381
SS-Chr 2BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 15 79.93 mg/dl 1.96 7.59 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37124 401
SS-Chr 2BN/Mcwi absolute change in body temperature controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 12 -0.08 degrees C 0.18 0.62 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 15696 381
SS-Chr 2BN/Mcwi mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 10 124.3 mmHg 7.17 22.68 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 15133 381
SS-Chr 2BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine albumin amount male 80 days-99 days 10 73.9 mg/d 13.02 41.18 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52628 482
SS-Chr 2BN/Mcwi heart rate controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 9 404.44 beats/min 17.49 52.47 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14736 381
SS-Chr 2BN/Mcwi partial pressure of blood carbon dioxide (Pco2) resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 12 31.0 mmHg 0.74 2.56 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 13447 381
SS-Chr 2BN/Mcwi heart rate resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 12 402.23 beats/min 7.1 24.61 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17759 381
SS-Chr 2BN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 9 -5.97 mmHg 0.73 2.2 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19673 381
SS-Chr 2BN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 11 -4.61 mmHg 0.42 1.39 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19680 381
SS-Chr 2BN/Mcwi blood pH control condition PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 9 7.47 null 0.01 0.04 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20663 381
SS-Chr 2BN/Mcwi serum total protein level control condition (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 9 6.33 g/dl 0.09 0.26 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37266 401
SS-Chr 2BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 13 44.29 ml/min 2.89 10.43 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20235 381
SS-Chr 2BN/Mcwi heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 9 167.88 beats/min 8.18 24.53 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48972 461
SS-Chr 2BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 10 1140.1 s 35.39 111.91 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50250 461
SS-Chr 2BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77 days-91 days 10 16.0 mmol/l 0.61 1.94 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42085 401
SS-Chr 2BN/Mcwi blood neutrophil count control condition (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77 days-91 days 6 0.81 x 1000 cells/ul 0.16 0.38 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38972 401
SS-Chr 2BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 15 20.1 pg 0.15 0.57 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42572 401
SS-Chr 2BN/Mcwi percent change in tidal volume controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 13 172.11 % 6.79 24.47 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54450 381
SS-Chr 2BN/Mcwi percent change in tidal volume controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 12 167.35 % 4.74 16.42 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54453 381
SS-Chr 2BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 10 32.0 g/dl 0.16 0.51 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39800 401
SS-Chr 2BN/Mcwi total white blood cell count control condition (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77 days-91 days 9 5.68 x 1000 cells/ul 0.53 1.59 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39953 401
SS-Chr 2BN/Mcwi systolic blood pressure control condition Viel EC, et al., Am J Physiol Heart Circ Physiol. 2010 Mar;298(3):H938-44. Epub 2009 Dec 31. arterial blood pressure trait male 84 days 12 150.0 mmHg 3.0 10.39 tail cuff plethysmography 0.0 0 67228 730
SS-Chr 2BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 7 1.54 mg/kg 0.23 0.62 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58929 526
SS-Chr 2BN/Mcwi blood monocyte count control condition (for 14 days) PhysGen Biochemistry data monocyte quantity female 77 days-91 days 9 0.3 x 1000 cells/ul 0.07 0.2 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40362 401
SS-Chr 2BN/Mcwi serum alkaline phosphatase activity level control condition (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 6 175.5 U/l 18.0 44.1 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37526 401
SS-Chr 2BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount female 77 days-91 days 10 2.28 g/dl 0.16 0.51 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40573 401
SS-Chr 2BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77 days-91 days 10 23.5 mg/dl 0.83 2.64 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40851 401
SS-Chr 2BN/Mcwi serum alanine aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77 days-91 days 9 45.0 U/l 3.58 10.74 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37775 401
SS-Chr 2BN/Mcwi serum alanine aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 6 43.33 U/l 2.93 7.17 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37783 401
SS-Chr 2BN/Mcwi lung dry weight to body weight ratio control condition (for 14 days) PhysGen Lung data lung mass male 77 days-91 days 10 0.87 g/kg 0.02 0.05 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59530 526
SS-Chr 2BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 15 5.73 x 1000 cells/ul 0.32 1.25 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41530 401
SS-Chr 2BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77 days-91 days 15 0.02 x 1000 cells/ul 0.01 0.04 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41674 401
SS-Chr 2BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 13 31.38 mmol/l 1.51 5.45 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38288 401
SS-Chr 2BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 10 0.54 IU/g 0.09 0.3 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47510 461
SS-Chr 2BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 41.31 mmHg 5.41 17.11 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46440 461
SS-Chr 2BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 8 159.27 mmHg 6.89 19.5 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48647 461
SS-Chr 2BN/Mcwi mean corpuscular volume control condition (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77 days-91 days 9 57.83 fl 0.15 0.45 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38715 401
SS-Chr 2BN/Mcwi mean corpuscular volume control condition (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 6 58.57 fl 0.33 0.81 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38723 401
SS-Chr 2BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 10 0.95 g 0.03 0.08 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45432 461
SS-Chr 2BN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 15 58.0 % 5.65 21.87 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57283 522
SS-Chr 2BN/Mcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 12 30.85 ml/min 2.19 7.57 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16174 381
SS-Chr 2BN/Mcwi heart right ventricle weight to left ventricle weight ratio control condition (for 14 days) PhysGen Lung data heart right ventricle mass female 77 days-91 days 15 0.22 null 0.02 0.08 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 57969 526
SS-Chr 2BN/Mcwi tidal volume controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 13 0.5 ml 0.05 0.19 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16496 381
SS-Chr 2BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 16 37.8 ml/min/kg 2.34 9.36 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58026 526
SS-Chr 2BN/Mcwi FAPGG metabolism-surface area product FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 10 45.56 ml/min/kg 6.69 21.15 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58302 526
SS-Chr 2BN/Mcwi absolute change in partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 10 11.48 mmHg 1.71 5.39 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16299 381
SS-Chr 2BN/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 10 18.2 % 1.59 5.03 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56298 522
SS-Chr 2BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 16 -7.24 null 0.04 0.15 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 56162 522
SS-Chr 2BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 19 0.05 umol/l 0.01 0.02 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54733 522
SS-Chr 2BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 9 0.56 E-7mole 0.09 0.28 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56585 522
SS-Chr 2BN/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 16 31.13 % 3.38 13.52 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55157 522
SS-Chr 2BN/Mcwi sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 11 99.55 % 0.28 0.93 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56485 522
SS-Chr 2BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 10 6.15 g/kg 0.12 0.38 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45683 461
SS-Chr 2BN/Mcwi left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 142.43 mmHg 4.4 13.21 balloon tipped catheter with pressure transducer in isolated perfused heart 0 46777 461
SS-Chr 2BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 6.11 mmHg 0.15 0.42 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47224 461
SS-Chr 2BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 15 5.58 ml/min/g 0.38 1.48 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46224 461
SS-Chr 2BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 9 6.65 ml/min/g 0.58 1.74 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46228 461
SS-Chr 2BN/Mcwi percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 15 post-ischemic value/pre-ischemic value x 100% 50.28 % 4.11 15.91 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46089 461
SS-Chr 2BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 74.56 mmHg 9.82 31.06 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45293 461
SS-Chr 2BN/Mcwi renal afferent arteriole diameter controlled sodium chloride content diet (1 %) (between 70 and 91 days) then controlled ex vivo artery perfusion pressure (60 mmHg) (for 0.1 hours) Miller B, et al., J Clin Invest. 2016 Jul 1;126(7):2533-46. doi: 10.1172/JCI75079. Epub 2016 Jun 6. kidney arteriole morphology trait not specified 91 days-133 days 6 20.8 um 1.0 2.45 ex vivo videomicroscopy renal afferent arteriole 120.0 0 ex vivo videomicroscopy (MMO:0000319) renal afferent arteriole diameter (CMO:0003725) renal arteriole morphology trait 106500 3030
SS-Chr 2BN/Mcwi urine total protein excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data total urine protein amount male 80 days-99 days 10 174.3 mg/d 23.06 72.93 automated urine total protein analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52728 482
SS-Chr 2BN/Mcwi percent change in respiration rate controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 13 168.93 % 10.58 38.13 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54244 381
SS-Chr 2BN/Mcwi mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 12 127.43 mmHg 6.53 22.62 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 15140 381
SS-Chr 2BN/Mcwi percent change in ventilation controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 13 %change=VE during7-9 min hypercapnia/control during standard conditions 290.59 % 20.45 73.73 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14221 381
SS-Chr 2BN/Mcwi heart rate control condition PhysGen Respiratory data heart pumping trait male 82 days-99 days 8 424.03 beats/min 15.3 43.29 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 15973 381
SS-Chr 2BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 10 6.36 g/dl 0.15 0.46 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36985 401
SS-Chr 2BN/Mcwi percent change in ventilation controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 12 %change=VE during7-9 min hypercapnia/control during standard conditions 124.64 % 7.16 24.8 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18566 381
SS-Chr 2BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 13 48.77 ml/min 4.43 15.97 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18689 381
SS-Chr 2BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 12 451.08 beats/min 16.57 57.41 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17551 381
SS-Chr 2BN/Mcwi creatinine clearance controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data glomerular filtration trait female 80 days-99 days 10 1.53 ml/min 0.14 0.44 urine creatinine analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52183 482
SS-Chr 2BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount male 80 days-99 days 9 0.35 mg/dl 0.02 0.05 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52238 482
SS-Chr 2BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 13 0.29 IU/g 0.05 0.17 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47365 461
SS-Chr 2BN/Mcwi percent change in left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 44.34 % 7.87 24.89 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46346 461
SS-Chr 2BN/Mcwi left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 15 107.85 mmHg 5.48 21.24 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 44838 461
SS-Chr 2BN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 14 -7.21 null 0.1 0.38 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56972 522
SS-Chr 2BN/Mcwi blood eosinophil count control condition (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77 days-91 days 6 0.01 x 1000 cells/ul 0.01 0.03 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41480 401
SS-Chr 2BN/Mcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 12 26.73 ml/min 2.24 7.77 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16713 381
SS-Chr 2BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 10 904.2 s 30.66 96.96 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49326 461
SS-Chr 2BN/Mcwi time to peak heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 15 1193.93 s 35.63 137.99 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46571 461
SS-Chr 2BN/Mcwi left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 148.18 mmHg 4.5 13.5 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45531 461
SS-Chr 2BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 115.87 mmHg 11.06 34.98 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49911 461
SS-Chr 2BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 10 0.44 IU/g 0.11 0.35 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47502 461
SS-Chr 2BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass female 77 days-91 days 10 0.25 null 0.02 0.07 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58756 526
SS-Chr 2BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 10 0.04 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59434 526
SS-Chr 2BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 10 19.96 pg 0.15 0.48 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42568 401
SS-Chr 2BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 10 9.16 x 10E6 cells/ul 0.11 0.33 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39260 401
SS-Chr 2BN/Mcwi serum globulin level control condition (for 14 days) PhysGen Biochemistry data blood globulin amount female 77 days-91 days 9 2.21 g/dl 0.06 0.17 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 41095 401
SS-Chr 2BN/Mcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 12 0.32 ml 0.02 0.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15424 381
SS-Chr 2BN/Mcwi partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 12 107.43 mmHg 2.53 8.76 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 15063 381
SS-Chr 2BN/Mcwi absolute change in body temperature resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 12 0.21 degrees C 0.16 0.54 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16022 381
SS-Chr 2BN/Mcwi percent change in tidal volume controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 13 174.66 % 6.01 21.66 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54110 381
SS-Chr 2BN/Mcwi percent change in respiration rate controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 12 147.93 % 5.89 20.4 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54247 381
SS-Chr 2BN/Mcwi absolute change in partial pressure of blood carbon dioxide resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 10 -4.2 mmHg 0.57 1.81 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20096 381
SS-Chr 2BN/Mcwi absolute change in partial pressure of blood carbon dioxide resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 12 -3.09 mmHg 0.67 2.32 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20101 381
SS-Chr 2BN/Mcwi absolute change in mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 9 13.51 mmHg 1.67 5.0 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 20745 381
SS-Chr 2BN/Mcwi mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 8 124.86 mmHg 3.65 10.31 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 19911 381
SS-Chr 2BN/Mcwi mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 11 128.91 mmHg 3.38 11.22 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 18955 381
SS-Chr 2BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77 days-91 days 10 160.9 U/l 9.51 30.06 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36402 401
SS-Chr 2BN/Mcwi minute ventilation controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 13 78.41 ml/min 7.3 26.32 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14523 381
SS-Chr 2BN/Mcwi blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 12 7.45 null 0.02 0.05 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14617 381
SS-Chr 2BN/Mcwi urine potassium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine potassium amount male 80 days-99 days 10 1.47 mEq/d 0.18 0.58 flame atomic emission spectrometry 0 urine potassium analysis Moms were fed Teklad, pups used in studies were fed Dyets 52975 482
SS-Chr 2BN/Mcwi urine total protein excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data total urine protein amount female 80 days-99 days 10 65.93 mg/d 11.1 35.11 automated urine total protein analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52722 482
SS-Chr 2BN/Mcwi urine sodium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine sodium amount male 80 days-99 days 10 18.08 mEq/d 2.1 6.64 flame atomic emission spectrometry 0 Moms were fed Teklad, pups used in studies were fed Dyets 52779 482
SS-Chr 2BN/Mcwi heart rate resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 12 414.56 beats/min 7.88 27.31 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17754 381
SS-Chr 2BN/Mcwi body weight control condition PhysGen Respiratory data body mass female 82 days-99 days 19 173.9 g 2.7 11.6 whole body digital scale 0 Moms and pups used in studies were fed Dyets 17840 381
SS-Chr 2BN/Mcwi blood pH control condition PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 11 7.45 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20669 381
SS-Chr 2BN/Mcwi serum sodium level control condition (for 14 days) PhysGen Biochemistry data blood sodium amount female 77 days-91 days 9 145.33 mmol/l 0.76 2.29 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36558 401
SS-Chr 2BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 12 9.47 mg/dl 0.11 0.37 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36651 401
SS-Chr 2BN/Mcwi left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 5.75 mmHg 0.15 0.46 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49204 461
SS-Chr 2BN/Mcwi body temperature resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 12 37.39 degrees C 0.12 0.41 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 18140 381
SS-Chr 2BN/Mcwi blood pH resting on treadmill (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 12 7.48 null 0.0 0.01 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 20173 381
SS-Chr 2BN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 9 -48.02 mmHg 1.86 5.59 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19504 381
SS-Chr 2BN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 11 -47.67 mmHg 1.24 4.1 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19511 381
SS-Chr 2BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 13 0.05 degrees C 0.14 0.51 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20336 381
SS-Chr 2BN/Mcwi time to onset of heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 15 979.67 s 39.77 154.03 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50142 461
SS-Chr 2BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 1105.2 s 28.59 90.41 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50254 461
SS-Chr 2BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 15 63.15 fl 0.52 2.0 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38772 401
SS-Chr 2BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount female 77 days-91 days 10 109.5 mmol/l 0.48 1.51 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39140 401
SS-Chr 2BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 13 14.92 mmol/l 0.4 1.44 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42089 401
SS-Chr 2BN/Mcwi serum aspartate aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 6 72.33 U/l 8.02 19.65 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42493 401
SS-Chr 2BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 14 0.27 mg/dl 0.02 0.06 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39603 401
SS-Chr 2BN/Mcwi total white blood cell count control condition (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 6 6.12 x 1000 cells/ul 0.7 1.7 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39961 401
SS-Chr 2BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity female 77 days-91 days 10 0.36 x 1000 cells/ul 0.06 0.19 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39697 401
SS-Chr 2BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 15 31.85 g/dl 0.11 0.41 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39804 401
SS-Chr 2BN/Mcwi serum total bilirubin level control condition (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77 days-91 days 9 0.1 mg/dl 0.0 0.0 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42951 401
SS-Chr 2BN/Mcwi plasma anion gap control condition (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77 days-91 days 9 22.67 mmol/l 0.62 1.87 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 43199 401
SS-Chr 2BN/Mcwi percent change in respiration rate controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 13 182.78 % 9.48 34.16 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53659 381
SS-Chr 2BN/Mcwi percent change in respiration rate controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 12 161.21 % 7.47 25.89 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53662 381
SS-Chr 2BN/Mcwi mean corpuscular hemoglobin control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 9 18.72 pg 0.08 0.23 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40266 401
SS-Chr 2BN/Mcwi blood monocyte count control condition (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 6 0.54 x 1000 cells/ul 0.14 0.35 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40370 401
SS-Chr 2BN/Mcwi serum alkaline phosphatase activity level control condition (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77 days-91 days 9 142.33 U/l 11.71 35.13 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37518 401
SS-Chr 2BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 15 2.75 g/dl 0.14 0.53 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40577 401
SS-Chr 2BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77 days-91 days 12 20.08 mg/dl 1.22 4.21 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40855 401
SS-Chr 2BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 15 7.63 x 1000 cells/ul 0.42 1.64 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40953 401
SS-Chr 2BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 16 0.18 mmHg x min x kg x ml-1 0.01 0.04 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59574 526
SS-Chr 2BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 10 18.3 g/dl 0.21 0.67 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 37991 401
SS-Chr 2BN/Mcwi serum globulin level control condition (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 6 2.25 g/dl 0.08 0.19 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 41103 401
SS-Chr 2BN/Mcwi serum phosphate level control condition (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77 days-91 days 9 8.18 mg/dl 0.31 0.93 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37895 401
SS-Chr 2BN/Mcwi serum phosphate level control condition (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 6 8.25 mg/dl 0.45 1.09 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37903 401
SS-Chr 2BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77 days-91 days 10 4.26 x 1000 cells/ul 0.19 0.62 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41526 401
SS-Chr 2BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77 days-91 days 10 24.8 mmol/l 0.66 2.1 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38284 401
SS-Chr 2BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount female 77 days-91 days 10 148.7 mg/dl 5.96 18.84 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38553 401
SS-Chr 2BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 49.04 mmHg 6.1 19.3 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46444 461
SS-Chr 2BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77 days-91 days 10 0.11 mg/dl 0.01 0.03 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41891 401
SS-Chr 2BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 10 209.89 beats/min 13.97 44.19 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47605 461
SS-Chr 2BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 54.93 % 5.3 16.76 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48550 461
SS-Chr 2BN/Mcwi maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 16 1.34 g/mg 0.11 0.44 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57391 522
SS-Chr 2BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 16 13.41 ml/min/kg 0.86 3.43 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57827 526
SS-Chr 2BN/Mcwi tidal volume controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 12 0.55 ml 0.04 0.13 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16500 381
SS-Chr 2BN/Mcwi absolute change in partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 12 6.53 mmHg 2.2 7.63 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16304 381
SS-Chr 2BN/Mcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 13 36.13 ml/min 3.26 11.74 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16717 381
SS-Chr 2BN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 15 -6.96 null 0.08 0.32 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55684 522
SS-Chr 2BN/Mcwi concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 11 0.03 10E-7mol/l 0.01 0.02 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55755 522
SS-Chr 2BN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 14 63.07 % 5.21 19.51 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54837 522
SS-Chr 2BN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 9 42.56 % 4.54 13.63 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54845 522
SS-Chr 2BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 16 0.06 umol/l 0.01 0.02 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54963 522
SS-Chr 2BN/Mcwi concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 14 0.03 10E-7mol/l 0.01 0.03 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56250 522
SS-Chr 2BN/Mcwi sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 14 98.21 % 0.74 2.78 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56325 522
SS-Chr 2BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77 days-91 days 10 0.02 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58512 526
SS-Chr 2BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 19.88 ml/min/kg 1.94 6.13 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58691 526
SS-Chr 2BN/Mcwi sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 12 98.08 % 0.98 3.4 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56490 522
SS-Chr 2BN/Mcwi calculated pulmonary vascular resistance normalized to body weight Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 0.13 mmHg x min x kg x ml-1 0.02 0.05 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59956 526
SS-Chr 2BN/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 16 45.63 % 2.16 8.65 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57187 522
SS-Chr 2BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 7.37 ml/min/g 0.83 2.61 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44741 461
SS-Chr 2BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 6.52 ml/min/g 0.72 2.27 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44745 461
SS-Chr 2BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 15 11.72 ml/min/g 0.89 3.46 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46893 461
SS-Chr 2BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 159.65 mmHg 8.57 25.7 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45752 461
SS-Chr 2BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 12.68 ml/min/g 0.99 3.13 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46680 461
SS-Chr 2BN/Mcwi left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 62.35 mmHg 9.05 27.15 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47938 461
SS-Chr 2BN/Mcwi percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 57.46 % 9.24 29.22 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46093 461
SS-Chr 2BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 86.63 % 3.63 11.47 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48322 461
SS-Chr 2BN/Mcwi heart rate control condition PhysGen Respiratory data heart pumping trait female 82 days-99 days 10 414.41 beats/min 20.67 65.36 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 20962 381
SS-Chr 2BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 12 123.34 % 8.05 27.88 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53778 381
SS-Chr 2BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 12 116.59 % 5.53 19.17 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53910 381
SS-Chr 2BN/Mcwi body weight control condition PhysGen Respiratory data body mass male 82 days-99 days 17 273.4 g 7.0 29.0 whole body digital scale 0 Moms and pups used in studies were fed Dyets 17844 381
SS-Chr 2BN/Mcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 13 0.4 ml 0.03 0.11 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18009 381
SS-Chr 2BN/Mcwi absolute change in body temperature controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 13 -0.12 degrees C 0.13 0.48 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 15692 381
SS-Chr 2BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine albumin amount female 80 days-99 days 10 13.96 mg/d 1.96 6.2 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52622 482
SS-Chr 2BN/Mcwi heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 15 219.96 beats/min 11.58 44.84 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48220 461
SS-Chr 2BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 9 0.29 IU/g 0.06 0.17 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47372 461
SS-Chr 2BN/Mcwi percent change in left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 15 post-ischemic value/pre-ischemic value x 100% 79.77 % 2.97 11.51 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 44941 461
SS-Chr 2BN/Mcwi plasma creatinine level control condition (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 6 0.2 mg/dl 0.03 0.06 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 42722 401
SS-Chr 2BN/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 16 56.69 % 2.26 9.03 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57192 522
SS-Chr 2BN/Mcwi logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 14 -8.76 null 0.1 0.36 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56038 522
SS-Chr 2BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 10 5.99 % 1.93 6.1 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49725 461
SS-Chr 2BN/Mcwi serum potassium level control condition (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 6 4.03 mmol/l 0.2 0.48 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 43403 401
SS-Chr 2BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 7 155.92 mmHg 10.04 26.56 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48651 461
SS-Chr 2BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 70.72 % 3.38 10.69 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48783 461
SS-Chr 2BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 16 11.32 ml/min/kg 0.47 1.9 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57625 526
SS-Chr 2BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 18 -7.39 null 0.1 0.41 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 55342 522
SS-Chr 2BN/Mcwi renal afferent arteriole diameter controlled sodium chloride content diet (1 %) (between 70 and 91 days) then controlled ex vivo artery perfusion pressure (60 mmHg) (for 0.1 hours) Miller B, et al., J Clin Invest. 2016 Jul 1;126(7):2533-46. doi: 10.1172/JCI75079. Epub 2016 Jun 6. kidney arteriole morphology trait not specified 91 days-133 days 6 20.7 um 1.8 4.41 ex vivo videomicroscopy renal afferent arteriole 120.0 0 ex vivo videomicroscopy (MMO:0000319) renal afferent arteriole diameter (CMO:0003725) renal arteriole morphology trait 106505 3030