Phenominer Database Results (168 results)

 
 
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Strain Phenotype Conditions Study Experiment Name Sex Age # of Animals Formula Value Units SEM SD Method Method Duration Post Insult Time Value Clinical Measurement Notes Experiment Notes Record ID Study ID
SS-Chr 12BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount female 82 days-99 days 3 23.18 mmHg 0.55 0.96 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17283 381
SS-Chr 12BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 11 123.34 % 8.64 28.64 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53776 381
SS-Chr 12BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 11 103.27 % 5.67 18.79 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54009 381
SS-Chr 12BN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 3 -8.65 mmHg 1.18 2.04 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19675 381
SS-Chr 12BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 1102.7 s 47.78 151.09 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50248 461
SS-Chr 12BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 9 28.33 mmHg 3.4 10.19 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50018 461
SS-Chr 12BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 8 22.5 mmol/l 0.63 1.77 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42083 401
SS-Chr 12BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 7 8.49 x 10E6 cells/ul 0.13 0.35 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39262 401
SS-Chr 12BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 8 19.89 pg 0.15 0.43 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42566 401
SS-Chr 12BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 7 20.56 pg 0.35 0.92 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42570 401
SS-Chr 12BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 8 110.54 % 6.74 19.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54352 381
SS-Chr 12BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 8 0.34 mg/dl 0.03 0.07 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39597 401
SS-Chr 12BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77 days-91 days 8 44.63 U/l 5.68 16.06 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40739 401
SS-Chr 12BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass male 77 days-91 days 10 1.25 g/kg 0.02 0.07 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59678 526
SS-Chr 12BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 8 17.66 g/dl 0.26 0.73 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 37989 401
SS-Chr 12BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77 days-91 days 7 0.01 x 1000 cells/ul 0.01 0.03 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41672 401
SS-Chr 12BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 10 241.02 beats/min 10.44 33.03 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47607 461
SS-Chr 12BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 33.39 % 3.14 9.93 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48552 461
SS-Chr 12BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 40.6 mmHg 6.49 20.54 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46438 461
SS-Chr 12BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount female 77 days-91 days 8 153.63 mg/dl 2.43 6.86 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38555 401
SS-Chr 12BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 11 37.6 degrees C 0.21 0.69 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16593 381
SS-Chr 12BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 0.46 null 0.03 0.08 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58138 526
SS-Chr 12BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 7 8.76 IU/g 1.36 3.61 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46010 461
SS-Chr 12BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 5.12 mmHg 0.29 0.91 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47222 461
SS-Chr 12BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 227.39 beats/min 5.69 18.0 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45169 461
SS-Chr 12BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 11 35.77 ml/min 2.09 6.95 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20229 381
SS-Chr 12BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77 days-91 days 8 130.25 U/l 8.18 23.14 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36404 401
SS-Chr 12BN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 3 -42.7 mmHg 5.64 9.77 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19506 381
SS-Chr 12BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 10 12.57 IU/g 2.32 7.35 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46004 461
SS-Chr 12BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 8 36.71 degrees C 0.56 1.59 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16597 381
SS-Chr 12BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass male 49 days-63 days 10 154.6 g 9.1 28.8 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49571 461
SS-Chr 12BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 10 883.5 s 25.53 80.74 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49324 461
SS-Chr 12BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 10 18.75 % 2.96 9.36 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49719 461
SS-Chr 12BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 6 0.7 mg/kg 0.16 0.39 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58931 526
SS-Chr 12BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 78.2 % 6.58 20.82 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48777 461
SS-Chr 12BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 9 0.13 mmHg x min x kg x ml-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59568 526
SS-Chr 12BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 11 0.29 ml 0.02 0.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15254 381
SS-Chr 12BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 8 5.55 g/dl 0.03 0.09 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36987 401
SS-Chr 12BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount female 77 days-91 days 8 9.44 mg/dl 0.09 0.24 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36649 401
SS-Chr 12BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 4 446.64 beats/min 26.84 53.68 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17546 381
SS-Chr 12BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 3 60.6 mmHg 4.41 7.64 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20511 381
SS-Chr 12BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 10 1079.9 s 30.41 96.17 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50252 461
SS-Chr 12BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77 days-91 days 7 63.31 fl 0.39 1.04 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38770 401
SS-Chr 12BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 8 107.5 mmol/l 0.33 0.93 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39138 401
SS-Chr 12BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 8 97.0 U/l 10.6 29.98 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42791 401
SS-Chr 12BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount female 77 days-91 days 8 142.5 mmol/l 0.68 1.93 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39413 401
SS-Chr 12BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 11 125.74 % 10.19 33.81 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54349 381
SS-Chr 12BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 8 0.34 x 1000 cells/ul 0.06 0.18 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39695 401
SS-Chr 12BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 7 1.64 mg/kg 0.29 0.78 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58927 526
SS-Chr 12BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount female 77 days-91 days 8 4.55 mmol/l 0.2 0.57 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38091 401
SS-Chr 12BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77 days-91 days 7 6.53 x 1000 cells/ul 0.39 1.04 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41528 401
SS-Chr 12BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 52.86 mmHg 3.32 10.49 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46442 461
SS-Chr 12BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 81.94 mmHg 7.92 25.05 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48645 461
SS-Chr 12BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 9 0.03 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58510 526
SS-Chr 12BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass female 77 days-91 days 10 0.44 null 0.01 0.04 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58758 526
SS-Chr 12BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 87.24 mmHg 7.84 24.79 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45750 461
SS-Chr 12BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 11.18 ml/min/g 0.54 1.72 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46674 461
SS-Chr 12BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 45.22 % 3.81 12.06 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47098 461
SS-Chr 12BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 27.17 mmHg 4.91 15.53 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45291 461
SS-Chr 12BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 82.61 % 3.47 9.8 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48320 461
SS-Chr 12BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 8 9.45 mg/dl 0.08 0.24 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36645 401
SS-Chr 12BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 9 0.4 null 0.02 0.07 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58134 526
SS-Chr 12BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 10 887.3 s 53.31 168.57 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49320 461
SS-Chr 12BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 8 31.86 g/dl 0.13 0.37 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39798 401
SS-Chr 12BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 81.85 mmHg 2.26 7.16 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49913 461
SS-Chr 12BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77 days-91 days 8 31.88 mg/dl 2.85 8.06 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40849 401
SS-Chr 12BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 9 14.73 ml/min/kg 1.15 3.45 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57619 526
SS-Chr 12BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 8 %change=VE during 2-3 min hypoxia/control during standard conditions 133.86 % 10.6 29.99 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13705 381
SS-Chr 12BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 5 119.54 mmHg 16.45 36.78 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14366 381
SS-Chr 12BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount male 82 days-99 days 3 23.68 mmHg 2.87 4.98 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17276 381
SS-Chr 12BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 8 101.67 % 6.97 19.72 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54012 381
SS-Chr 12BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 8 248.75 U/l 15.9 44.97 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36400 401
SS-Chr 12BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 8 92.88 mg/dl 3.32 9.4 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37118 401
SS-Chr 12BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77 days-91 days 8 90.88 mg/dl 3.03 8.56 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37122 401
SS-Chr 12BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 5 465.07 beats/min 23.98 53.62 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17539 381
SS-Chr 12BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 11 127.86 breaths/min 9.0 29.86 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18286 381
SS-Chr 12BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 8 114.64 breaths/min 10.14 28.68 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18290 381
SS-Chr 12BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 11 0.07 degrees C 0.14 0.47 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20330 381
SS-Chr 12BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 10 30.8 mmHg 2.58 8.15 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50022 461
SS-Chr 12BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 7 53.79 % 0.98 2.6 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39016 401
SS-Chr 12BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount female 77 days-91 days 8 4.05 g/dl 0.03 0.08 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42258 401
SS-Chr 12BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77 days-91 days 8 0.4 mg/dl 0.02 0.05 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39601 401
SS-Chr 12BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 8 17.63 mmol/l 0.78 2.2 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38282 401
SS-Chr 12BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77 days-91 days 8 17.75 mmol/l 0.59 1.67 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38286 401
SS-Chr 12BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 10 0.83 g 0.03 0.1 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45430 461
SS-Chr 12BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 9 26.82 ml/min/kg 2.11 6.32 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57821 526
SS-Chr 12BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77 days-91 days 9 0.03 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58514 526
SS-Chr 12BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 10 5.42 g/kg 0.24 0.75 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45669 461
SS-Chr 12BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 5.3 mmHg 0.25 0.8 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47218 461
SS-Chr 12BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 28.99 mmHg 2.96 9.36 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45295 461
SS-Chr 12BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 11 112.37 % 3.7 12.26 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53908 381
SS-Chr 12BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 11 40.38 ml/min 3.35 11.11 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18683 381
SS-Chr 12BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77 days-91 days 8 0.01 x 1000 cells/ul 0.01 0.02 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41668 401
SS-Chr 12BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount male 77 days-91 days 8 132.38 mg/dl 2.25 6.37 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38551 401
SS-Chr 12BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass male 77 days-91 days 10 167.6 g 10.8 34.3 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59083 526
SS-Chr 12BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 8 59.5 U/l 4.45 12.59 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40735 401
SS-Chr 12BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 2 0.22 IU/g 0.04 0.06 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47504 461
SS-Chr 12BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 8 55.44 % 0.73 2.06 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39012 401
SS-Chr 12BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 8 0.24 ml 0.03 0.08 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15258 381
SS-Chr 12BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 8 0.28 ml 0.03 0.09 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13948 381
SS-Chr 12BN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 3 7.56 null 0.03 0.06 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17084 381
SS-Chr 12BN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 3 7.55 null 0.03 0.05 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17090 381
SS-Chr 12BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 8 117.42 % 9.12 25.79 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53779 381
SS-Chr 12BN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 3 0.05 null 0.0 0.0 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19826 381
SS-Chr 12BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 8 5.26 g/dl 0.16 0.45 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36983 401
SS-Chr 12BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 3 60.38 mmHg 2.09 3.62 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20518 381
SS-Chr 12BN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 3 -51.35 mmHg 5.64 9.76 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19499 381
SS-Chr 12BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass female 49 days-63 days 10 141.8 g 3.5 11.0 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49579 461
SS-Chr 12BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 8 62.45 fl 0.5 1.4 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38766 401
SS-Chr 12BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 8 3.56 g/dl 0.1 0.28 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42254 401
SS-Chr 12BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77 days-91 days 8 22.0 mmol/l 0.5 1.41 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42087 401
SS-Chr 12BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77 days-91 days 8 64.0 U/l 4.23 11.98 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42795 401
SS-Chr 12BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 7 32.44 g/dl 0.4 1.06 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39802 401
SS-Chr 12BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 8 1.7 g/dl 0.07 0.19 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40571 401
SS-Chr 12BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity female 77 days-91 days 7 53.79 % 0.98 2.6 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59282 526
SS-Chr 12BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 8 8.46 x 1000 cells/ul 0.51 1.46 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40947 401
SS-Chr 12BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 0.14 mmHg x min x kg x ml-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59572 526
SS-Chr 12BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 276.05 beats/min 7.51 23.76 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47603 461
SS-Chr 12BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 9 68.11 ml/min/kg 5.49 16.48 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58020 526
SS-Chr 12BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 55.36 ml/min/kg 6.39 19.18 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58024 526
SS-Chr 12BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass male 77 days-91 days 10 0.43 null 0.03 0.1 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58754 526
SS-Chr 12BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 10.03 ml/min/g 0.8 2.53 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46678 461
SS-Chr 12BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 42.29 % 3.17 10.03 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47102 461
SS-Chr 12BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 11 %change=VE during 2-3 min hypoxia/control during standard conditions 138.91 % 8.94 29.64 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13701 381
SS-Chr 12BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 11 0.32 ml 0.01 0.04 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13944 381
SS-Chr 12BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 8 197.99 beats/min 5.97 16.89 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45173 461
SS-Chr 12BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 82.73 % 2.36 7.46 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48316 461
SS-Chr 12BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 5.09 ml/min/g 0.54 1.71 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44739 461
SS-Chr 12BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity female 77 days-91 days 7 0.23 x 1000 cells/ul 0.04 0.1 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39699 401
SS-Chr 12BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 8 10.89 mg/dl 0.28 0.78 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37615 401
SS-Chr 12BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 7 17.44 g/dl 0.34 0.91 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 37993 401
SS-Chr 12BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 11 126.23 breaths/min 8.11 26.9 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14815 381
SS-Chr 12BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 8 123.55 breaths/min 14.73 41.65 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14819 381
SS-Chr 12BN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 3 0.05 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19820 381
SS-Chr 12BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 8 122.61 % 9.52 26.92 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53911 381
SS-Chr 12BN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 3 -6.75 mmHg 2.74 4.75 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19668 381
SS-Chr 12BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 8 30.97 ml/min 3.68 10.4 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18687 381
SS-Chr 12BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 8 26.93 ml/min 2.58 7.3 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20233 381
SS-Chr 12BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 8 -0.67 degrees C 0.62 1.77 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20334 381
SS-Chr 12BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount female 77 days-91 days 8 107.5 mmol/l 0.6 1.69 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39142 401
SS-Chr 12BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77 days-91 days 7 0.66 x 1000 cells/ul 0.15 0.39 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43249 401
SS-Chr 12BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass female 77 days-91 days 10 156.2 g 2.9 9.3 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59087 526
SS-Chr 12BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77 days-91 days 8 24.75 mg/dl 2.09 5.92 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40853 401
SS-Chr 12BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77 days-91 days 7 7.43 x 1000 cells/ul 0.47 1.24 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40951 401
SS-Chr 12BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77 days-91 days 8 9.96 mg/dl 0.23 0.65 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37619 401
SS-Chr 12BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass female 77 days-91 days 10 1.42 g/kg 0.01 0.04 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59682 526
SS-Chr 12BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 10 0.84 g 0.07 0.22 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45426 461
SS-Chr 12BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 32.58 % 4.79 15.16 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48548 461
SS-Chr 12BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 8 0.1 mg/dl 0.0 0.0 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41889 401
SS-Chr 12BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 14.27 ml/min/kg 1.67 5.0 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57623 526
SS-Chr 12BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 24.57 ml/min/kg 2.22 6.65 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57825 526
SS-Chr 12BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 4.18 ml/min/g 0.39 1.24 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44743 461
SS-Chr 12BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 10 5.89 g/kg 0.25 0.8 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45677 461
SS-Chr 12BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 92.13 mmHg 3.86 12.2 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45754 461
SS-Chr 12BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 4 116.75 mmHg 11.49 22.98 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14373 381
SS-Chr 12BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 8 7.08 x 1000 cells/ul 0.39 1.09 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41524 401
SS-Chr 12BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77 days-91 days 8 1.04 x 1000 cells/ul 0.14 0.41 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43245 401
SS-Chr 12BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 67.78 mmHg 8.57 27.09 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49909 461
SS-Chr 12BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 9 10.34 % 1.49 4.47 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49723 461
SS-Chr 12BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77 days-91 days 8 0.13 mg/dl 0.02 0.05 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41893 401
SS-Chr 12BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 9 0.28 IU/g 0.07 0.2 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47496 461
SS-Chr 12BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 89.61 % 2.61 8.26 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48781 461
SS-Chr 12BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount female 77 days-91 days 8 1.5 g/dl 0.03 0.08 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40575 401
SS-Chr 12BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 87.0 mmHg 3.78 11.94 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48649 461
SS-Chr 12BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77 days-91 days 8 55.44 % 0.73 2.06 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59278 526
SS-Chr 12BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 8 8.88 x 10E6 cells/ul 0.1 0.29 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39258 401
SS-Chr 12BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 8 5.09 mmol/l 0.23 0.65 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38087 401
SS-Chr 12BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 8 142.63 mmol/l 0.73 2.07 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39409 401