SS-Chr 11BN/Mcwi |
acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70 days-84 days |
10 |
71.3 |
% |
6.47 |
20.47 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
Moms and pups used in studies were fed Teklad |
57262 |
522 |
SS-Chr 11BN/Mcwi |
acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70 days-84 days |
9 |
82.11 |
% |
5.21 |
15.62 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
Moms and pups used in studies were fed Teklad |
54812 |
522 |
SS-Chr 11BN/Mcwi |
acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70 days-84 days |
8 |
79.75 |
% |
6.46 |
18.27 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
Moms and pups used in studies were fed Teklad |
54818 |
522 |
SS-Chr 11BN/Mcwi |
logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70 days-84 days |
9 |
-6.81 |
null |
0.05 |
0.14 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
Moms and pups used in studies were fed Teklad |
56947 |
522 |
SS-Chr 11BN/Mcwi |
maximum contractile force per wet weight of aorta |
potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
female |
70 days-84 days |
11 |
1.59 |
g/mg |
0.06 |
0.2 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
Moms and pups used in studies were fed Teklad |
55820 |
522 |
SS-Chr 11BN/Mcwi |
maximum contractile force per wet weight of aorta |
potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
male |
70 days-84 days |
10 |
0.92 |
g/mg |
0.06 |
0.18 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
Moms and pups used in studies were fed Teklad |
55826 |
522 |
SS-Chr 11BN/Mcwi |
concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70 days-84 days |
8 |
2.45 |
E-7mole |
0.0 |
0.0 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
Moms and pups used in studies were fed Teklad |
56558 |
522 |
SS-Chr 11BN/Mcwi |
maximum contractile force per wet weight of aorta |
controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
male |
70 days-84 days |
10 |
0.81 |
g/mg |
0.07 |
0.21 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
Moms and pups used in studies were fed Teklad |
57372 |
522 |
SS-Chr 11BN/Mcwi |
concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70 days-84 days |
9 |
1.63 |
E-7mole |
0.18 |
0.55 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
Moms and pups used in studies were fed Teklad |
56552 |
522 |
SS-Chr 11BN/Mcwi |
maximum contractile force per wet weight of aorta |
controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
female |
70 days-84 days |
10 |
0.87 |
g/mg |
0.1 |
0.31 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
Moms and pups used in studies were fed Teklad |
57366 |
522 |
SS-Chr 11BN/Mcwi |
concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
female |
70 days-84 days |
9 |
0.02 |
umol/l |
0.01 |
0.02 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
Moms and pups used in studies were fed Teklad |
54938 |
522 |
SS-Chr 11BN/Mcwi |
concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
male |
70 days-84 days |
10 |
0.02 |
umol/l |
0.01 |
0.02 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
Moms and pups used in studies were fed Teklad |
54944 |
522 |
SS-Chr 11BN/Mcwi |
acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70 days-84 days |
9 |
74.44 |
% |
5.59 |
16.76 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
Moms and pups used in studies were fed Teklad |
57256 |
522 |
SS-Chr 11BN/Mcwi |
concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) |
phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70 days-84 days |
10 |
1.3 |
E-7mole |
0.28 |
0.9 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
Moms and pups used in studies were fed Teklad |
55926 |
522 |
SS-Chr 11BN/Mcwi |
concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) |
phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70 days-84 days |
11 |
2.05 |
E-7mole |
0.45 |
1.48 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
Moms and pups used in studies were fed Teklad |
55932 |
522 |
SS-Chr 11BN/Mcwi |
concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) |
phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
female |
70 days-84 days |
10 |
0.02 |
umol/l |
0.0 |
0.01 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
Moms and pups used in studies were fed Teklad |
54706 |
522 |
SS-Chr 11BN/Mcwi |
logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) |
phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70 days-84 days |
9 |
-6.92 |
null |
0.09 |
0.26 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
Moms and pups used in studies were fed Teklad |
55657 |
522 |
SS-Chr 11BN/Mcwi |
logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) |
phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70 days-84 days |
10 |
-6.85 |
null |
0.1 |
0.3 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
Moms and pups used in studies were fed Teklad |
55663 |
522 |
SS-Chr 11BN/Mcwi |
concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) |
phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
male |
70 days-84 days |
11 |
0.03 |
umol/l |
0.01 |
0.04 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
Moms and pups used in studies were fed Teklad |
54712 |
522 |
SS-Chr 11BN/Mcwi |
logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) |
phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
male |
70 days-84 days |
11 |
-7.85 |
null |
0.14 |
0.48 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
EC50 value is moles/liter |
Moms and pups used in studies were fed Teklad |
55313 |
522 |
SS-Chr 11BN/Mcwi |
logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
female |
70 days-84 days |
9 |
-7.73 |
null |
0.11 |
0.34 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
EC50 value is moles/liter |
Moms and pups used in studies were fed Teklad |
56137 |
522 |
SS-Chr 11BN/Mcwi |
logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
male |
70 days-84 days |
10 |
-7.8 |
null |
0.12 |
0.39 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
EC50 value is moles/liter |
Moms and pups used in studies were fed Teklad |
56143 |
522 |
SS-Chr 11BN/Mcwi |
logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70 days-84 days |
8 |
-6.84 |
null |
0.04 |
0.11 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
Moms and pups used in studies were fed Teklad |
56953 |
522 |
SS-Chr 11BN/Mcwi |
logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) |
phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
female |
70 days-84 days |
10 |
-7.9 |
null |
0.11 |
0.36 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
EC50 value is moles/liter |
Moms and pups used in studies were fed Teklad |
55307 |
522 |