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PhenoMiner Database Result        View data table  |  Download data table  |  View expanded data table        


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# of AnimalsPhenotypeStrainSexValueUnitsConditionsRecord IDCondition 1Condition 2aCondition 2bCondition 3aCondition 3bCondition 4Condition 5
3urine calcium excretion rateWKYfemale2.91mg/dcontrolled calcium content diet (0.6 %) (between 4 and 10 days)67502controlled calcium content diet (0.6 %) (between 4 and 10 days)
3urine calcium excretion rateWKYmale0.95mg/dcontrolled calcium content diet (0.6 %) (between 4 and 10 days)67503controlled calcium content diet (0.6 %) (between 4 and 10 days)
24systolic blood pressureWKYmale167.3mmHgnaive control condition11901naive control condition
24diastolic blood pressureWKYmale102.1mmHgnaive control condition11902naive control condition
28mean arterial blood pressureWKYmale120.6mmHgnaive control condition65080naive control condition
28mean arterial blood pressureWKYmale126mmHgnaive control condition65084naive control condition
4systolic blood pressureWKYmale131.7mmHgcontrolled sodium content diet (0.4 %) (for 63 days)12584controlled sodium content diet (0.4 %) (for 63 days)
4systolic blood pressureWKYfemale127mmHgcontrolled sodium content diet (0.4 %) (for 63 days)12585controlled sodium content diet (0.4 %) (for 63 days)
4body weightWKYmale318gcontrolled sodium content diet (0.4 %) (for 122 days) then controlled sodium content diet (1.4 %) (for 210 days)12588controlled sodium content diet (0.4 %) (for 122 days)controlled sodium content diet (1.4 %) (for 210 days)
4body weightWKYfemale200.8gcontrolled sodium content diet (0.4 %) (for 122 days) then controlled sodium content diet (1.4 %) (for 210 days)12589controlled sodium content diet (0.4 %) (for 122 days)controlled sodium content diet (1.4 %) (for 210 days)
4heart wet weightWKYmale0.784gcontrolled sodium content diet (0.4 %) (for 122 days) then controlled sodium content diet (1.4 %) (for 210 days)12592controlled sodium content diet (0.4 %) (for 122 days)controlled sodium content diet (1.4 %) (for 210 days)
4heart weight to body weight ratioWKYmale2.5g/kgcontrolled sodium content diet (0.4 %) (for 122 days) then controlled sodium content diet (1.4 %) (for 210 days)12593controlled sodium content diet (0.4 %) (for 122 days)controlled sodium content diet (1.4 %) (for 210 days)
4heart wet weightWKYfemale0.554gcontrolled sodium content diet (0.4 %) (for 122 days) then controlled sodium content diet (1.4 %) (for 210 days)12594controlled sodium content diet (0.4 %) (for 122 days)controlled sodium content diet (1.4 %) (for 210 days)
4heart weight to body weight ratioWKYfemale2.8g/kgcontrolled sodium content diet (0.4 %) (for 122 days) then controlled sodium content diet (1.4 %) (for 210 days)12596controlled sodium content diet (0.4 %) (for 122 days)controlled sodium content diet (1.4 %) (for 210 days)
8urine calcium excretion rateWKYmale0.78mg/dcontrolled calcium content diet (1.2 %) (between 5 and 9 days)67890controlled calcium content diet (1.2 %) (between 5 and 9 days)
8urine calcium excretion rateWKYfemale2.11mg/dcontrolled calcium content diet (1.2 %) (between 5 and 9 days)67892controlled calcium content diet (1.2 %) (between 5 and 9 days)
5ethanol drink intake rate to body weight ratioWKYmale0.56g/d/kgcontrolled ethanol content drinking water (10 %) (for 2 days) then water (for 14 days) and controlled ethanol content drinking water (10 %) (for 14 days)69898controlled ethanol content drinking water (10 %) (for 2 days)water (for 14 days)controlled ethanol content drinking water (10 %) (for 14 days)
11ethanol drink intake rate to body weight ratioWKYfemale2.54g/d/kgcontrolled ethanol content drinking water (10 %) (for 2 days) then water (for 14 days) and controlled ethanol content drinking water (10 %) (for 14 days)69899controlled ethanol content drinking water (10 %) (for 2 days)water (for 14 days)controlled ethanol content drinking water (10 %) (for 14 days)
5ethanol intake volume to total fluid intake volume ratioWKYmale10.2%controlled ethanol content drinking water (10 %) (for 2 days) then water (for 14 days) and controlled ethanol content drinking water (10 %) (for 14 days)69900controlled ethanol content drinking water (10 %) (for 2 days)water (for 14 days)controlled ethanol content drinking water (10 %) (for 14 days)
11ethanol intake volume to total fluid intake volume ratioWKYfemale45.7%controlled ethanol content drinking water (10 %) (for 2 days) then water (for 14 days) and controlled ethanol content drinking water (10 %) (for 14 days)69901controlled ethanol content drinking water (10 %) (for 2 days)water (for 14 days)controlled ethanol content drinking water (10 %) (for 14 days)
N/Adecrease in blood ethanol level to body weight ratio per unit timeWKYmale315mg/kg/hethanol (20 %) (between 0.5 and 3.5 hours)96820ethanol (20 %) (between 0.5 and 3.5 hours)
N/Adecrease in blood ethanol level to body weight ratio per unit timeWKYfemale379mg/kg/hethanol (20 %) (between 0.5 and 3.5 hours)97040ethanol (20 %) (between 0.5 and 3.5 hours)
N/Ablood ethanol clearance rateWKYmale33.6mg/dl/hethanol (20 %) (between 0.5 and 3.5 hours)97043ethanol (20 %) (between 0.5 and 3.5 hours)
N/Ablood ethanol clearance rateWKYfemale41.3mg/dl/hethanol (20 %) (between 0.5 and 3.5 hours)97044ethanol (20 %) (between 0.5 and 3.5 hours)
10timed urine volumeWKYmale17.1ml/dvehicle control condition (1 null) 99119vehicle control condition (1 null)
10timed urine volumeWKYmale140.19ml/dstreptozotocin (60 mg/kg) 99120streptozotocin (60 mg/kg)
10timed urine volumeWKYmale133.86ml/dstreptozotocin (60 mg/kg) then gene transfer of the enhanced green fluorescent protein gene using an adenovirus vector (40000000000 PFU) 99121streptozotocin (60 mg/kg) gene transfer of the enhanced green fluorescent protein gene using an adenovirus vector (40000000000 PFU)
10timed urine volumeWKYmale62.68ml/dstreptozotocin (60 mg/kg) then gene transfer of the murine angiotensin I converting enzyme 2 gene using an adenovirus vector (40000000000 PFU) 99122streptozotocin (60 mg/kg) gene transfer of the murine angiotensin I converting enzyme 2 gene using an adenovirus vector (40000000000 PFU)
10timed urine volumeWKYmale58.33ml/dstreptozotocin (60 mg/kg) then benazepril (10 mg/kg/d) 99123streptozotocin (60 mg/kg) benazepril (10 mg/kg/d)
10timed urine volumeWKYmale53.91ml/dstreptozotocin (60 mg/kg) then benazepril (10 mg/kg/d) then gene transfer of the murine angiotensin I converting enzyme 2 gene using an adenovirus vector (40000000000 PFU) 99124streptozotocin (60 mg/kg) benazepril (10 mg/kg/d) gene transfer of the murine angiotensin I converting enzyme 2 gene using an adenovirus vector (40000000000 PFU)
10single kidney wet weight as percentage of body weightWKYmale0.341%vehicle control condition (1 null) 99113vehicle control condition (1 null)
10single kidney wet weight to body weight ratioWKYmale5.47g/kgstreptozotocin (60 mg/kg) 99114streptozotocin (60 mg/kg)
10single kidney wet weight to body weight ratioWKYmale5.42g/kgstreptozotocin (60 mg/kg) then gene transfer of the enhanced green fluorescent protein gene using an adenovirus vector (40000000000 PFU) 99115streptozotocin (60 mg/kg) gene transfer of the enhanced green fluorescent protein gene using an adenovirus vector (40000000000 PFU)
10single kidney wet weight to body weight ratioWKYmale4.46g/kgstreptozotocin (60 mg/kg) then gene transfer of the murine angiotensin I converting enzyme 2 gene using an adenovirus vector (40000000000 PFU) 99116streptozotocin (60 mg/kg) gene transfer of the murine angiotensin I converting enzyme 2 gene using an adenovirus vector (40000000000 PFU)
10single kidney wet weight to body weight ratioWKYmale4.73g/kgstreptozotocin (60 mg/kg) then benazepril (10 mg/kg/d) 99117streptozotocin (60 mg/kg) benazepril (10 mg/kg/d)
10single kidney wet weight to body weight ratioWKYmale4.72g/kgstreptozotocin (60 mg/kg) then benazepril (10 mg/kg/d) then gene transfer of the murine angiotensin I converting enzyme 2 gene using an adenovirus vector (40000000000 PFU) 99118streptozotocin (60 mg/kg) benazepril (10 mg/kg/d) gene transfer of the murine angiotensin I converting enzyme 2 gene using an adenovirus vector (40000000000 PFU)
10body weightWKYmale450.39gvehicle control condition (1 null) 99107vehicle control condition (1 null)
10body weightWKYmale259.65gstreptozotocin (60 mg/kg) 99108streptozotocin (60 mg/kg)
10body weightWKYmale261.43gstreptozotocin (60 mg/kg) then gene transfer of the enhanced green fluorescent protein gene using an adenovirus vector (40000000000 null) 99109streptozotocin (60 mg/kg) gene transfer of the enhanced green fluorescent protein gene using an adenovirus vector (40000000000 null)
10body weightWKYmale295.56gstreptozotocin (60 mg/kg) then gene transfer of the murine angiotensin I converting enzyme 2 gene using an adenovirus vector (40000000000 null) 99110streptozotocin (60 mg/kg) gene transfer of the murine angiotensin I converting enzyme 2 gene using an adenovirus vector (40000000000 null)
10body weightWKYmale287.24gstreptozotocin (60 mg/kg) then benazepril (10 mg/kg/d) 99111streptozotocin (60 mg/kg) benazepril (10 mg/kg/d)
10body weightWKYmale286.6gstreptozotocin (60 mg/kg) then benazepril (10 mg/kg/d) then gene transfer of the murine angiotensin I converting enzyme 2 gene using an adenovirus vector (40000000000 null) 99112streptozotocin (60 mg/kg) benazepril (10 mg/kg/d) gene transfer of the murine angiotensin I converting enzyme 2 gene using an adenovirus vector (40000000000 null)
10blood glucose levelWKYmale160.56mg/dlvehicle control condition (1 null) 99101vehicle control condition (1 null)
10blood glucose levelWKYmale520.92mg/dlstreptozotocin (60 mg/kg) 99102streptozotocin (60 mg/kg)
10blood glucose levelWKYmale533.7mg/dlstreptozotocin (60 mg/kg) then gene transfer of the enhanced green fluorescent protein gene using an adenovirus vector (40000000000 PFU) 99103streptozotocin (60 mg/kg) gene transfer of the enhanced green fluorescent protein gene using an adenovirus vector (40000000000 PFU)
10blood glucose levelWKYmale523.26mg/dlstreptozotocin (60 mg/kg) then gene transfer of the murine angiotensin I converting enzyme 2 gene using an adenovirus vector (40000000000 null) 99104streptozotocin (60 mg/kg) gene transfer of the murine angiotensin I converting enzyme 2 gene using an adenovirus vector (40000000000 null)
10blood glucose levelWKYmale537.12mg/dlstreptozotocin (60 mg/kg) then benazepril (10 mg/kg/d) 99105streptozotocin (60 mg/kg) benazepril (10 mg/kg/d)
10blood glucose levelWKYmale534.6mg/dlstreptozotocin (60 mg/kg) then benazepril (10 mg/kg/d) then gene transfer of the murine angiotensin I converting enzyme 2 gene using an adenovirus vector (40000000000 null) 99106streptozotocin (60 mg/kg) benazepril (10 mg/kg/d) gene transfer of the murine angiotensin I converting enzyme 2 gene using an adenovirus vector (40000000000 null)
9kidney sclerotic glomeruli count to total glomeruli count ratioWKYmale4%naive control condition (for 280 days)100256naive control condition (for 280 days)
9kidney sclerotic glomerular volume to total kidney glomerular volume ratioWKYmale0.3%naive control condition (for 280 days)100260naive control condition (for 280 days)
9kidney glomerulus volumeWKYmale0.7x 10E6 um3naive control condition (for 280 days)100252naive control condition (for 280 days)
9serum creatinine levelWKYmale0.53mg/dlnaive control condition (for 280 days)100246naive control condition (for 280 days)
9urine protein excretion rateWKYmale20mg/dnaive control condition (for 280 days)100239naive control condition (for 280 days)
9systolic blood pressureWKYmale130mmHgnaive control condition (for 280 days)100232naive control condition (for 280 days)
5heart left ventricle weight to body weight ratioWKYmale2.29mg/gnaive control condition (for 0 hours)103482naive control condition (for 0 hours)
5body weightWKYmale260gnaive control condition (for 0 hours)103476naive control condition (for 0 hours)
5systolic blood pressureWKYmale125mmHgnaive control condition (for 0 hours)103470naive control condition (for 0 hours)
7blood very low density lipoprotein triglyceride levelWKYmale0.96192mg/dlstandard diet (for 20 days)98922standard diet (for 20 days)
7blood very low density lipoprotein triglyceride levelWKYmale1.76352mg/dlcontrolled cholesterol content diet (1 %) (for 20 days)98923controlled cholesterol content diet (1 %) (for 20 days)
7plasma triglyceride levelWKYmale0.48mmol/lstandard diet (for 20 days)98918standard diet (for 20 days)
7plasma triglyceride levelWKYmale0.67mmol/lcontrolled cholesterol content diet (1 %) (for 20 days)98919controlled cholesterol content diet (1 %) (for 20 days)
7plasma high density lipoprotein cholesterol levelWKYmale28.5714mg/dlstandard diet (for 20 days)98914standard diet (for 20 days)
7plasma high density lipoprotein cholesterol levelWKYmale21.6216mg/dlcontrolled cholesterol content diet (1 %) (for 20 days)98915controlled cholesterol content diet (1 %) (for 20 days)
7plasma low density lipoprotein cholesterol levelWKYmale10.0386mg/dlstandard diet (for 20 days)98910standard diet (for 20 days)
7plasma low density lipoprotein cholesterol levelWKYmale7.722mg/dlcontrolled cholesterol content diet (1 %) (for 20 days)98911controlled cholesterol content diet (1 %) (for 20 days)
7plasma very low density lipoprotein cholesterol levelWKYmale2.7027mg/dlstandard diet (for 20 days)98906standard diet (for 20 days)
7plasma very low density lipoprotein cholesterol levelWKYmale8.1081mg/dlcontrolled cholesterol content diet (1 %) (for 20 days)98907controlled cholesterol content diet (1 %) (for 20 days)
7plasma total cholesterol levelWKYmale61.3899mg/dlstandard diet (for 20 days)98902standard diet (for 20 days)
7plasma total cholesterol levelWKYmale66.0231mg/dlcontrolled cholesterol content diet (1 %) (for 20 days)98903controlled cholesterol content diet (1 %) (for 20 days)
7liver triglyceride levelWKYmale11.42478196mg/gstandard diet (for 20 days)98898standard diet (for 20 days)
7liver triglyceride levelWKYmale19.00885488mg/gcontrolled cholesterol content diet (1 %) (for 20 days)98899controlled cholesterol content diet (1 %) (for 20 days)
7liver cholesterol levelWKYmale3.9167645mg/gstandard diet (for 20 days)98894standard diet (for 20 days)
7liver cholesterol levelWKYmale5.8886795mg/gcontrolled cholesterol content diet (1 %) (for 20 days)98895controlled cholesterol content diet (1 %) (for 20 days)
6heart weight to body weight ratioWKYmale2.43g/kgcontrolled in utero environment (100 % of calories) (for 22 days)101687controlled in utero environment (100 % of calories) (for 22 days)
7heart weight to body weight ratioWKYmale2.47g/kgcontrolled in utero environment (30 % of calories) (for 22 days)101688controlled in utero environment (30 % of calories) (for 22 days)
5plasma aldosterone levelWKYmale470pg/mlcontrolled in utero environment (100 % of calories) (for 22 days)101691controlled in utero environment (100 % of calories) (for 22 days)
6plasma aldosterone levelWKYmale1130pg/mlcontrolled in utero environment (30 % of calories) (for 22 days)101692controlled in utero environment (30 % of calories) (for 22 days)
6plasma angiotensin II levelWKYmale41.3pg/mlcontrolled in utero environment (100 % of calories) (for 22 days)101689controlled in utero environment (100 % of calories) (for 22 days)
7plasma angiotensin II levelWKYmale73.8pg/mlcontrolled in utero environment (30 % of calories) (for 22 days)101690controlled in utero environment (30 % of calories) (for 22 days)
5systolic blood pressureWKYmale104mmHgcontrolled in utero environment (100 % of calories) (for 22 days)101683controlled in utero environment (100 % of calories) (for 22 days)
6systolic blood pressureWKYmale125mmHgcontrolled in utero environment (30 % of calories) (for 22 days)101684controlled in utero environment (30 % of calories) (for 22 days)
5mean arterial blood pressureWKYmale66mmHgcontrolled in utero environment (100 % of calories) (for 22 days)101685controlled in utero environment (100 % of calories) (for 22 days)
6mean arterial blood pressureWKYmale79mmHgcontrolled in utero environment (30 % of calories) (for 22 days)101686controlled in utero environment (30 % of calories) (for 22 days)
6plasma corticosterone levelWKYfemale123ng/mlcontrolled calorie content diet (100 % of calories) (for 14 days)99072controlled calorie content diet (100 % of calories) (for 14 days)
6plasma corticosterone levelWKYfemale409ng/mlcontrolled calorie content diet (30 % of calories) (for 14 days)99071controlled calorie content diet (30 % of calories) (for 14 days)
26body weightWKYnot specified6.64gcontrolled in utero environment (100 % of calories) (for 22 days)99073controlled in utero environment (100 % of calories) (for 22 days)
36body weightWKYnot specified4.91gin utero condition (30 % of calories) (for 22 days)99074in utero condition (30 % of calories) (for 22 days)
17body weightWKYmale454gcontrolled in utero environment (100 % of calories) (for 22 days)99075controlled in utero environment (100 % of calories) (for 22 days)
18body weightWKYmale436gin utero condition (30 % of calories) (for 22 days)99076in utero condition (30 % of calories) (for 22 days)
5kidney renin levelWKYmale136.5ng/ml/hcontrolled in utero environment (100 % of calories) (for 22 days)99099controlled in utero environment (100 % of calories) (for 22 days)
6kidney renin levelWKYmale145.3ng/ml/hcontrolled in utero environment (30 % of calories) (for 22 days)99100controlled in utero environment (30 % of calories) (for 22 days)
5plasma renin activity levelWKYmale0.43ng/ml/hcontrolled in utero environment (100 % of calories) (for 22 days)99097controlled in utero environment (100 % of calories) (for 22 days)
6plasma renin activity levelWKYmale0.48ng/ml/hcontrolled in utero environment (30 % of calories) (for 22 days)99098controlled in utero environment (30 % of calories) (for 22 days)
7plasma sodium levelWKYmale139.41mmol/lcontrolled in utero environment (100 % of calories) (for 22 days)99089controlled in utero environment (100 % of calories) (for 22 days)
7plasma sodium levelWKYmale148.97mmol/lcontrolled in utero environment (30 % of calories) (for 22 days)99090controlled in utero environment (30 % of calories) (for 22 days)
7plasma potassium levelWKYmale10.28mmol/lcontrolled in utero environment (100 % of calories) (for 22 days)99091controlled in utero environment (100 % of calories) (for 22 days)
7plasma potassium levelWKYmale11.98mmol/lcontrolled in utero environment (30 % of calories) (for 22 days)99092controlled in utero environment (30 % of calories) (for 22 days)
7urine sodium levelWKYmale57.21mmol/lcontrolled in utero environment (100 % of calories) (for 22 days)99093controlled in utero environment (100 % of calories) (for 22 days)
7urine sodium levelWKYmale55.41mmol/lcontrolled in utero environment (30 % of calories) (for 22 days)99094controlled in utero environment (30 % of calories) (for 22 days)
7urine potassium levelWKYmale122.72mmol/lcontrolled in utero environment (100 % of calories) (for 22 days)99095controlled in utero environment (100 % of calories) (for 22 days)
7urine potassium levelWKYmale112.58mmol/lcontrolled in utero environment (30 % of calories) (for 22 days)99096controlled in utero environment (30 % of calories) (for 22 days)
5kidney angiotensin I converting enzyme activity levelWKYmale0.35nmol/min/mgcontrolled in utero environment (100 % of calories) (for 22 days)99085controlled in utero environment (100 % of calories) (for 22 days)
6heart angiotensin I converting enzyme activity levelWKYmale0.08nmol/min/mgcontrolled in utero environment (30 % of calories) (for 22 days)99086controlled in utero environment (30 % of calories) (for 22 days)
6lung angiotensin I converting enzyme activity levelWKYmale13.33nmol/min/mgcontrolled in utero environment (30 % of calories) (for 22 days)99087controlled in utero environment (30 % of calories) (for 22 days)
6kidney angiotensin I converting enzyme activity levelWKYmale0.39nmol/min/mgcontrolled in utero environment (30 % of calories) (for 22 days)99088controlled in utero environment (30 % of calories) (for 22 days)
5lung angiotensin I converting enzyme 2 activity levelWKYmale0.07nmol/min/mgcontrolled in utero environment (100 % of calories) (for 22 days)99078controlled in utero environment (100 % of calories) (for 22 days)
5kidney angiotensin I converting enzyme 2 activity levelWKYmale1.69nmol/min/mgcontrolled in utero environment (100 % of calories) (for 22 days)99079controlled in utero environment (100 % of calories) (for 22 days)
6heart angiotensin I converting enzyme 2 activity levelWKYmale0.02nmol/min/mgcontrolled in utero environment (30 % of calories) (for 22 days)99080controlled in utero environment (30 % of calories) (for 22 days)
6lung angiotensin I converting enzyme 2 activity levelWKYmale0.14nmol/min/mgcontrolled in utero environment (30 % of calories) (for 22 days)99081controlled in utero environment (30 % of calories) (for 22 days)
6kidney angiotensin I converting enzyme 2 activity levelWKYmale1.56nmol/min/mgcontrolled in utero environment (30 % of calories) (for 22 days)99082controlled in utero environment (30 % of calories) (for 22 days)
5heart angiotensin I converting enzyme activity levelWKYmale0.08nmol/min/mgcontrolled in utero environment (100 % of calories) (for 22 days)99083controlled in utero environment (100 % of calories) (for 22 days)
5lung angiotensin I converting enzyme activity levelWKYmale9.05nmol/min/mgcontrolled in utero environment (100 % of calories) (for 22 days)99084controlled in utero environment (100 % of calories) (for 22 days)
5heart angiotensin I converting enzyme 2 activity levelWKYmale0.02nmol/min/mgcontrolled in utero environment (100 % of calories) (for 22 days)99077controlled in utero environment (100 % of calories) (for 22 days)
9afferent arteriolar plasma protein concentrationWKYmale5.4g/dl0.9% sodium chloride solution (3 ml) 1005670.9% sodium chloride solution (3 ml)
6afferent arteriolar plasma protein concentrationWKYmale4.7g/dlpuromycin aminonucleoside (50 mg/kg) 100568puromycin aminonucleoside (50 mg/kg)
8afferent arteriolar plasma protein concentrationWKYmale5.6g/dl0.9% sodium chloride solution (3 ml) 1005690.9% sodium chloride solution (3 ml)
9afferent arteriolar plasma protein concentrationWKYmale5.6g/dlpuromycin aminonucleoside (50 mg/kg) 100570puromycin aminonucleoside (50 mg/kg)
8afferent arteriolar plasma protein concentrationWKYmale5.5g/dlcontrolled enalapril content drinking water (50 mg/l) (for 7 days) then puromycin aminonucleoside (50 mg/kg) 100571controlled enalapril content drinking water (50 mg/l) (for 7 days)puromycin aminonucleoside (50 mg/kg)
9urine potassium excretion rateWKYmale0.5184mEq/d0.9% sodium chloride solution (3 ml) 1005080.9% sodium chloride solution (3 ml)
7urine potassium excretion rateWKYmale0.2016mEq/dpuromycin aminonucleoside (50 mg/kg) 100509puromycin aminonucleoside (50 mg/kg)
5urine potassium excretion rateWKYmale0.288mEq/dcontrolled enalapril content drinking water (50 mg/l) (for 22 days) then puromycin aminonucleoside (50 mg/kg) 100510controlled enalapril content drinking water (50 mg/l) (for 22 days)puromycin aminonucleoside (50 mg/kg)
8urine potassium excretion rateWKYmale0.8496mEq/d0.9% sodium chloride solution (3 ml) 1005110.9% sodium chloride solution (3 ml)
9urine potassium excretion rateWKYmale0.504mEq/dpuromycin aminonucleoside (50 mg/kg) 100512puromycin aminonucleoside (50 mg/kg)
8urine potassium excretion rateWKYmale0.4896mEq/dcontrolled enalapril content drinking water (50 mg/l) (for 7 days) then puromycin aminonucleoside (50 mg/kg) 100513controlled enalapril content drinking water (50 mg/l) (for 7 days)puromycin aminonucleoside (50 mg/kg)
9urine potassium excretion rateWKYmale1.9296mEq/d0.9% sodium chloride solution (3 ml) 1005140.9% sodium chloride solution (3 ml)
8urine potassium excretion rateWKYmale1.7136mEq/dpuromycin aminonucleoside (50 mg/kg) 100515puromycin aminonucleoside (50 mg/kg)
9urine potassium excretion rateWKYmale2.16mEq/dcontrolled enalapril content drinking water (50 mg/l) (for 497 days) then puromycin aminonucleoside (50 mg/kg) 100516controlled enalapril content drinking water (50 mg/l) (for 497 days)puromycin aminonucleoside (50 mg/kg)
9urine sodium excretion rateWKYmale0.5328mEq/d0.9% sodium chloride solution (3 ml) 1004990.9% sodium chloride solution (3 ml)
7urine sodium excretion rateWKYmale0.0288mEq/dpuromycin aminonucleoside (50 mg/kg) 100500puromycin aminonucleoside (50 mg/kg)
5urine sodium excretion rateWKYmale0.0432mEq/dcontrolled enalapril content drinking water (50 mg/l) (for 22 days) then puromycin aminonucleoside (50 mg/kg) 100501controlled enalapril content drinking water (50 mg/l) (for 22 days)puromycin aminonucleoside (50 mg/kg)
8urine sodium excretion rateWKYmale0.6336mEq/d0.9% sodium chloride solution (3 ml) 1005020.9% sodium chloride solution (3 ml)
9urine sodium excretion rateWKYmale0.3312mEq/dpuromycin aminonucleoside (50 mg/kg) 100503puromycin aminonucleoside (50 mg/kg)
8urine sodium excretion rateWKYmale0.3024mEq/dcontrolled enalapril content drinking water (50 mg/l) (for 7 days) then puromycin aminonucleoside (50 mg/kg) 100504controlled enalapril content drinking water (50 mg/l) (for 7 days)puromycin aminonucleoside (50 mg/kg)
9urine sodium excretion rateWKYmale0.5904mEq/d0.9% sodium chloride solution (3 ml) 1005050.9% sodium chloride solution (3 ml)
8urine sodium excretion rateWKYmale0.7344mEq/dpuromycin aminonucleoside (50 mg/kg) 100506puromycin aminonucleoside (50 mg/kg)
9urine sodium excretion rateWKYmale0.6912mEq/dcontrolled enalapril content drinking water (50 mg/kg) (for 497 days) then puromycin aminonucleoside (50 mg/l) 100507controlled enalapril content drinking water (50 mg/kg) (for 497 days)puromycin aminonucleoside (50 mg/l)
9plasma potassium levelWKYmale4.6mmol/l0.9% sodium chloride solution (3 ml) 1004900.9% sodium chloride solution (3 ml)
7plasma potassium levelWKYmale5.9mmol/lpuromycin aminonucleoside (50 mg/kg) 100491puromycin aminonucleoside (50 mg/kg)
5plasma potassium levelWKYmale5.8mmol/lcontrolled enalapril content drinking water (50 mg/l) (for 30 days) then puromycin aminonucleoside (50 mg/kg) 100492controlled enalapril content drinking water (50 mg/l) (for 30 days)puromycin aminonucleoside (50 mg/kg)
8plasma potassium levelWKYmale4.3mmol/l0.9% sodium chloride solution (3 ml) 1004930.9% sodium chloride solution (3 ml)
9plasma potassium levelWKYmale4.4mmol/lpuromycin aminonucleoside (50 mg/kg) 100494puromycin aminonucleoside (50 mg/kg)
8plasma potassium levelWKYmale4.7mmol/lcontrolled enalapril content drinking water (50 mg/l) (for 7 days) then puromycin aminonucleoside (50 mg/kg) 100495controlled enalapril content drinking water (50 mg/l) (for 7 days)puromycin aminonucleoside (50 mg/kg)
9plasma potassium levelWKYmale4.2mmol/l0.9% sodium chloride solution (3 ml) 1004960.9% sodium chloride solution (3 ml)
8plasma potassium levelWKYmale5mmol/lpuromycin aminonucleoside (50 mg/kg) 100497puromycin aminonucleoside (50 mg/kg)
9plasma potassium levelWKYmale4.7mmol/lcontrolled enalapril content drinking water (50 mg/l) (for 497 days) then puromycin aminonucleoside (50 mg/kg) 100498controlled enalapril content drinking water (50 mg/l) (for 497 days)puromycin aminonucleoside (50 mg/kg)
9plasma sodium levelWKYmale152mmol/l0.9% sodium chloride solution (3 ml) 1004810.9% sodium chloride solution (3 ml)
7plasma sodium levelWKYmale149mmol/lpuromycin aminonucleoside (50 mg/kg) 100482puromycin aminonucleoside (50 mg/kg)
5plasma sodium levelWKYmale138mmol/lcontrolled enalapril content drinking water (50 mg/l) (for 30 days) then puromycin aminonucleoside (50 mg/kg) 100483controlled enalapril content drinking water (50 mg/l) (for 30 days)puromycin aminonucleoside (50 mg/kg)
8plasma sodium levelWKYmale150mmol/l0.9% sodium chloride solution (3 ml) 1004840.9% sodium chloride solution (3 ml)
9plasma sodium levelWKYmale148mmol/lpuromycin aminonucleoside (50 mg/kg) 100485puromycin aminonucleoside (50 mg/kg)
8plasma sodium levelWKYmale148mmol/lcontrolled enalapril content drinking water (50 mg/l) (for 7 days) then puromycin aminonucleoside (50 mg/kg) 100486controlled enalapril content drinking water (50 mg/l) (for 7 days)puromycin aminonucleoside (50 mg/kg)
9plasma sodium levelWKYmale143mmol/l0.9% sodium chloride solution (3 ml) 1004870.9% sodium chloride solution (3 ml)
8plasma sodium levelWKYmale142mmol/lpuromycin aminonucleoside (50 mg/kg) 100488puromycin aminonucleoside (50 mg/kg)
9plasma sodium levelWKYmale146mmol/lcontrolled enalapril content drinking water (50 mg/l) (for 497 days) then puromycin aminonucleoside (50 mg/kg) 100489controlled enalapril content drinking water (50 mg/l) (for 497 days)puromycin aminonucleoside (50 mg/kg)
5renal plasma flowWKYmale3.9ml/minpuromycin aminonucleoside (50 mg/kg) 100600puromycin aminonucleoside (50 mg/kg)
5renal plasma flowWKYmale4.6ml/minpuromycin aminonucleoside (50 mg/kg) then saralasin (0.3 mg/kg/hr) 100601puromycin aminonucleoside (50 mg/kg) saralasin (0.3 mg/kg/hr)
5renal plasma flowWKYmale4.36ml/minpuromycin aminonucleoside (50 mg/kg) 100602puromycin aminonucleoside (50 mg/kg)
5renal plasma flowWKYmale4.37ml/minpuromycin aminonucleoside (50 mg/kg) then 0.9% sodium chloride solution (for 0.5 hours)100603puromycin aminonucleoside (50 mg/kg) 0.9% sodium chloride solution (for 0.5 hours)
9afferent arteriolar plasma flow rateWKYmale165nl/min0.9% sodium chloride solution (3 ml) 1005270.9% sodium chloride solution (3 ml)
6afferent arteriolar plasma flow rateWKYmale186nl/minpuromycin aminonucleoside (50 mg/kg) 100528puromycin aminonucleoside (50 mg/kg)
8afferent arteriolar plasma flow rateWKYmale191nl/min0.9% sodium chloride solution (3 ml) 1005290.9% sodium chloride solution (3 ml)
9afferent arteriolar plasma flow rateWKYmale169nl/minpuromycin aminonucleoside (50 mg/kg) 100530puromycin aminonucleoside (50 mg/kg)
8afferent arteriolar plasma flow rateWKYmale244nl/mincontrolled enalapril content drinking water (50 mg/l) (for 7 days) then puromycin aminonucleoside (50 mg/kg) 100531controlled enalapril content drinking water (50 mg/l) (for 7 days)puromycin aminonucleoside (50 mg/kg)
9renal plasma flowWKYmale4.5ml/min0.9% sodium chloride solution (3 ml) 1004630.9% sodium chloride solution (3 ml)
7renal plasma flowWKYmale3.66ml/minpuromycin aminonucleoside (50 mg/kg) 100464puromycin aminonucleoside (50 mg/kg)
5renal plasma flowWKYmale3.95ml/mincontrolled enalapril content drinking water (50 mg/l) (for 22 days) then puromycin aminonucleoside (50 mg/kg) 100465controlled enalapril content drinking water (50 mg/l) (for 22 days)puromycin aminonucleoside (50 mg/kg)
8renal plasma flowWKYmale4.65ml/min0.9% sodium chloride solution (3 ml) 1004660.9% sodium chloride solution (3 ml)
9renal plasma flowWKYmale3.79ml/minpuromycin aminonucleoside (50 mg/kg) 100467puromycin aminonucleoside (50 mg/kg)
8renal plasma flowWKYmale4.15ml/mincontrolled enalapril content drinking water (50 mg/l) (for 7 days) then puromycin aminonucleoside (50 mg/kg) 100468controlled enalapril content drinking water (50 mg/l) (for 7 days)puromycin aminonucleoside (50 mg/kg)
9renal plasma flowWKYmale4.99ml/min0.9% sodium chloride solution (3 ml) 1004690.9% sodium chloride solution (3 ml)
8renal plasma flowWKYmale4.18ml/minpuromycin aminonucleoside (50 mg/kg) 100470puromycin aminonucleoside (50 mg/kg)
9renal plasma flowWKYmale5.45ml/mincontrolled enalapril content drinking water (50 mg/l) (for 497 days) then puromycin aminonucleoside (50 mg/kg) 100471controlled enalapril content drinking water (50 mg/l) (for 497 days)puromycin aminonucleoside (50 mg/kg)
5afferent arteriolar plasma flow rateWKYmale270nl/minpuromycin aminonucleoside (50 mg/kg) 100612puromycin aminonucleoside (50 mg/kg)
5afferent arteriolar plasma flow rateWKYmale314nl/minpuromycin aminonucleoside (50 mg/kg) (for 0.5 hours) then saralasin (0.3 mg/kg/hr) 100613puromycin aminonucleoside (50 mg/kg) (for 0.5 hours)saralasin (0.3 mg/kg/hr)
9blood glomerular filtration rateWKYmale1.17ml/min0.9% sodium chloride solution (3 ml) 1004540.9% sodium chloride solution (3 ml)
7blood glomerular filtration rateWKYmale0.31ml/minpuromycin aminonucleoside (50 mg/kg) 100455puromycin aminonucleoside (50 mg/kg)
5blood glomerular filtration rateWKYmale0.38ml/mincontrolled enalapril content drinking water (50 mg/l) (for 22 days) then puromycin aminonucleoside (50 mg/kg) 100456controlled enalapril content drinking water (50 mg/l) (for 22 days)puromycin aminonucleoside (50 mg/kg)
8blood glomerular filtration rateWKYmale1.34ml/min0.9% sodium chloride solution (3 ml) 1004570.9% sodium chloride solution (3 ml)
9blood glomerular filtration rateWKYmale1.28ml/minpuromycin aminonucleoside (50 mg/kg) 100458puromycin aminonucleoside (50 mg/kg)
8blood glomerular filtration rateWKYmale1.25ml/mincontrolled enalapril content drinking water (50 mg/l) (for 7 days) then puromycin aminonucleoside (50 mg/kg) 100459controlled enalapril content drinking water (50 mg/l) (for 7 days)puromycin aminonucleoside (50 mg/kg)
9blood glomerular filtration rateWKYmale1.51ml/min0.9% sodium chloride solution (3 ml) 1004600.9% sodium chloride solution (3 ml)
8blood glomerular filtration rateWKYmale1.14ml/minpuromycin aminonucleoside (50 mg/kg) 100461puromycin aminonucleoside (50 mg/kg)
9blood glomerular filtration rateWKYmale1.43ml/mincontrolled enalapril content drinking water (50 mg/l) (for 497 days) then puromycin aminonucleoside (50 mg/kg) 100462controlled enalapril content drinking water (50 mg/l) (for 497 days)puromycin aminonucleoside (50 mg/kg)
5blood glomerular filtration rateWKYmale1.22ml/minpuromycin aminonucleoside (50 mg/kg) 100596puromycin aminonucleoside (50 mg/kg)
5blood glomerular filtration rateWKYmale1.49ml/minpuromycin aminonucleoside (50 mg/kg) then saralasin (0.3 mg/kg/hr) (for 0.5 hours)100597puromycin aminonucleoside (50 mg/kg) saralasin (0.3 mg/kg/hr) (for 0.5 hours)
5blood glomerular filtration rateWKYmale1.24ml/minpuromycin aminonucleoside (50 mg/kg) 100598puromycin aminonucleoside (50 mg/kg)
5blood glomerular filtration rateWKYmale1.19ml/minpuromycin aminonucleoside (50 mg/kg) then 0.9% sodium chloride solution (for 0.5 hours)100599puromycin aminonucleoside (50 mg/kg) 0.9% sodium chloride solution (for 0.5 hours)
9renal filtration fractionWKYmale0.32puromycin aminonucleoside (50 mg/kg) 100604puromycin aminonucleoside (50 mg/kg)
9renal filtration fractionWKYmale0.32puromycin aminonucleoside (50 mg/kg) then saralasin (0.3 mg/kg/hr) (for 0.5 hours)100605puromycin aminonucleoside (50 mg/kg) saralasin (0.3 mg/kg/hr) (for 0.5 hours)
9renal filtration fractionWKYmale0.29puromycin aminonucleoside (50 mg/kg) 100606puromycin aminonucleoside (50 mg/kg)
9renal filtration fractionWKYmale0.28puromycin aminonucleoside (50 mg/kg) then 0.9% sodium chloride solution (for 0.5 hours)100607puromycin aminonucleoside (50 mg/kg) 0.9% sodium chloride solution (for 0.5 hours)
5single nephron glomerular filtration rateWKYmale82nl/minpuromycin aminonucleoside (50 mg/kg) then saralasin (0.3 mg/kg/hr) (for 0.5 hours)100609puromycin aminonucleoside (50 mg/kg) saralasin (0.3 mg/kg/hr) (for 0.5 hours)
5single nephron glomerular filtration rateWKYmale65nl/minpuromycin aminonucleoside (50 mg/kg) 100610puromycin aminonucleoside (50 mg/kg)
5glomerular capillary ultrafiltration coefficientWKYmale0.162nl/(s x mmHg)puromycin aminonucleoside (50 mg/kg) then saralasin (0.3 mg/kg/hr) (for 0.5 hours)100617puromycin aminonucleoside (50 mg/kg) saralasin (0.3 mg/kg/hr) (for 0.5 hours)
9single nephron glomerular filtration rateWKYmale44.4nl/min0.9% sodium chloride solution (3 ml) 1005170.9% sodium chloride solution (3 ml)
6single nephron glomerular filtration rateWKYmale17nl/minpuromycin aminonucleoside (50 mg/kg) 100518puromycin aminonucleoside (50 mg/kg)
8single nephron glomerular filtration rateWKYmale52nl/min0.9% sodium chloride solution (3 ml) 1005190.9% sodium chloride solution (3 ml)
9single nephron glomerular filtration rateWKYmale50nl/minpuromycin aminonucleoside (50 mg/kg) 100520puromycin aminonucleoside (50 mg/kg)
8single nephron glomerular filtration rateWKYmale61nl/mincontrolled enalapril content drinking water (50 mg/l) (for 7 days) then puromycin aminonucleoside (50 mg/kg) 100521controlled enalapril content drinking water (50 mg/l) (for 7 days)puromycin aminonucleoside (50 mg/kg)
9single nephron filtration fractionWKYmale0.260.9% sodium chloride solution (3 ml) 1005220.9% sodium chloride solution (3 ml)
6single nephron filtration fractionWKYmale0.09puromycin aminonucleoside (50 mg/kg) 100523puromycin aminonucleoside (50 mg/kg)
8single nephron filtration fractionWKYmale0.280.9% sodium chloride solution (3 ml) 1005240.9% sodium chloride solution (3 ml)
9single nephron filtration fractionWKYmale0.31puromycin aminonucleoside (50 mg/kg) 100525puromycin aminonucleoside (50 mg/kg)
8single nephron filtration fractionWKYmale0.26controlled enalapril content drinking water (50 mg/l) (for 7 days) then puromycin aminonucleoside (50 mg/kg) 100526controlled enalapril content drinking water (50 mg/l) (for 7 days)puromycin aminonucleoside (50 mg/kg)
9renal filtration fractionWKYmale0.260.9% sodium chloride solution (3 ml) 1004720.9% sodium chloride solution (3 ml)
7renal filtration fractionWKYmale0.09puromycin aminonucleoside (50 mg/kg) 100473puromycin aminonucleoside (50 mg/kg)
5renal filtration fractionWKYmale0.09controlled enalapril content drinking water (50 mg/l) (for 22 days) then puromycin aminonucleoside (50 mg/kg) 100474controlled enalapril content drinking water (50 mg/l) (for 22 days)puromycin aminonucleoside (50 mg/kg)
8renal filtration fractionWKYmale0.260.9% sodium chloride solution (3 ml) 1004750.9% sodium chloride solution (3 ml)
9renal filtration fractionWKYmale0.34puromycin aminonucleoside (50 mg/kg) 100476puromycin aminonucleoside (50 mg/kg)
8renal filtration fractionWKYmale0.28controlled enalapril content drinking water (50 mg/l) (for 7 days) then puromycin aminonucleoside (50 mg/kg) 100477controlled enalapril content drinking water (50 mg/l) (for 7 days)puromycin aminonucleoside (50 mg/kg)
9renal filtration fractionWKYmale0.320.9% sodium chloride solution (3 ml) 1004780.9% sodium chloride solution (3 ml)
8renal filtration fractionWKYmale0.27puromycin aminonucleoside (50 mg/kg) 100479puromycin aminonucleoside (50 mg/kg)
9renal filtration fractionWKYmale0.28controlled enalapril content drinking water (50 mg/l) (for 497 days) then puromycin aminonucleoside (50 mg/kg) 100480controlled enalapril content drinking water (50 mg/l) (for 497 days)puromycin aminonucleoside (50 mg/kg)
5single nephron glomerular filtration rateWKYmale67nl/minpuromycin aminonucleoside (50 mg/kg) 100608puromycin aminonucleoside (50 mg/kg)
5single nephron glomerular filtration rateWKYmale57nl/minpuromycin aminonucleoside (50 mg/kg) then 0.9% sodium chloride solution (for 0.5 hours)100611puromycin aminonucleoside (50 mg/kg) 0.9% sodium chloride solution (for 0.5 hours)
5glomerular capillary ultrafiltration coefficientWKYmale0.055nl/(s x mmHg)puromycin aminonucleoside (50 mg/kg) 100616puromycin aminonucleoside (50 mg/kg)
9systolic blood pressureWKYmale106mmHg0.9% sodium chloride solution (3 ml) 1004450.9% sodium chloride solution (3 ml)
7systolic blood pressureWKYmale112mmHgpuromycin aminonucleoside (50 mg/kg) 100446puromycin aminonucleoside (50 mg/kg)
5systolic blood pressureWKYmale95mmHgcontrolled enalapril content drinking water (50 mg/l) (for 22 days) then puromycin aminonucleoside (50 mg/kg) 100447controlled enalapril content drinking water (50 mg/l) (for 22 days)puromycin aminonucleoside (50 mg/kg)
8systolic blood pressureWKYmale117mmHg0.9% sodium chloride solution (3 ml) 1004480.9% sodium chloride solution (3 ml)
9systolic blood pressureWKYmale121mmHgpuromycin aminonucleoside (50 mg/kg) 100449puromycin aminonucleoside (50 mg/kg)
8systolic blood pressureWKYmale100mmHgcontrolled enalapril content drinking water (50 mg/l) (between 63 and 77 days) then puromycin aminonucleoside (50 mg/kg) 100450controlled enalapril content drinking water (50 mg/l) (between 63 and 77 days)puromycin aminonucleoside (50 mg/kg)
9systolic blood pressureWKYmale108mmHg0.9% sodium chloride solution (3 ml) 1004510.9% sodium chloride solution (3 ml)
8systolic blood pressureWKYmale113mmHgpuromycin aminonucleoside (50 mg/kg) 100452puromycin aminonucleoside (50 mg/kg)
9systolic blood pressureWKYmale96mmHgcontrolled enalapril content drinking water (50 mg/l) (for 497 days) then puromycin aminonucleoside (50 mg/kg) 100453controlled enalapril content drinking water (50 mg/l) (for 497 days)puromycin aminonucleoside (50 mg/kg)
5systolic blood pressureWKYmale118mmHgpuromycin aminonucleoside (50 mg/kg) (for 70 days) then saralasin (0.3 mg/kg/hr) (for 0.5 hours)100593puromycin aminonucleoside (50 mg/kg) (for 70 days)saralasin (0.3 mg/kg/hr) (for 0.5 hours)
5systolic blood pressureWKYmale127mmHgpuromycin aminonucleoside (50 mg/kg) 100594puromycin aminonucleoside (50 mg/kg)
5systolic blood pressureWKYmale131mmHg0.9% sodium chloride solution (50 mg/kg) (for 0.5 hours) then 0.9% sodium chloride solution1005950.9% sodium chloride solution (50 mg/kg) (for 0.5 hours)0.9% sodium chloride solution
5systolic blood pressureWKYmale119mmHgpuromycin aminonucleoside (50 mg/kg) 100592puromycin aminonucleoside (50 mg/kg)
9hematocritWKYmale41%0.9% sodium chloride solution (3 ml) 1004360.9% sodium chloride solution (3 ml)
7hematocritWKYmale39%puromycin aminonucleoside (50 mg/kg) 100437puromycin aminonucleoside (50 mg/kg)
5hematocritWKYmale35%controlled enalapril content drinking water (50 mg/l) (for 30 days) then puromycin aminonucleoside (50 mg/kg) 100438controlled enalapril content drinking water (50 mg/l) (for 30 days)puromycin aminonucleoside (50 mg/kg)
8hematocritWKYmale45%0.9% sodium chloride solution (3 ml) 1004390.9% sodium chloride solution (3 ml)
9hematocritWKYmale43%puromycin aminonucleoside (50 mg/kg) 100440puromycin aminonucleoside (50 mg/kg)
8hematocritWKYmale43%controlled enalapril content drinking water (50 mg/l) (between 63 and 77 days) then puromycin aminonucleoside (50 mg/kg) 100441controlled enalapril content drinking water (50 mg/l) (between 63 and 77 days)puromycin aminonucleoside (50 mg/kg)
9hematocritWKYmale44%0.9% sodium chloride solution (3 ml) 1004420.9% sodium chloride solution (3 ml)
8hematocritWKYmale44%puromycin aminonucleoside (50 mg/kg) 100443puromycin aminonucleoside (50 mg/kg)
9hematocritWKYmale42%controlled enalapril content drinking water (50 mg/l) (for 497 days) then puromycin aminonucleoside (50 mg/kg) 100444controlled enalapril content drinking water (50 mg/l) (for 497 days)puromycin aminonucleoside (50 mg/kg)
12plasma renin activity levelWKYmale7.4ng/ml/hpuromycin aminonucleoside (50 mg/kg) 100425puromycin aminonucleoside (50 mg/kg)
12plasma renin activity levelWKYmale206.8ng/ml/hcontrolled enalapril content drinking water (50 mg/l) (between 63 and 77 days) then puromycin aminonucleoside (50 mg/kg) 100426controlled enalapril content drinking water (50 mg/l) (between 63 and 77 days)puromycin aminonucleoside (50 mg/kg)
10plasma renin activity levelWKYmale10.7ng/ml/h0.9% sodium chloride solution (3 ml) 1004210.9% sodium chloride solution (3 ml)
11plasma renin activity levelWKYmale8.8ng/ml/hpuromycin aminonucleoside (50 mg/kg) 100422puromycin aminonucleoside (50 mg/kg)
10plasma renin activity levelWKYmale100.3ng/ml/hcontrolled enalapril content drinking water (50 mg/l) (for 30 days) then puromycin aminonucleoside (50 mg/kg) 100423controlled enalapril content drinking water (50 mg/l) (for 30 days)puromycin aminonucleoside (50 mg/kg)
11plasma renin activity levelWKYmale11.9ng/ml/h0.9% sodium chloride solution (3 ml) 1004240.9% sodium chloride solution (3 ml)
10serum albumin levelWKYmale3.5g/dl0.9% sodium chloride solution (3 ml) 1004150.9% sodium chloride solution (3 ml)
11serum albumin levelWKYmale1.3g/dlpuromycin aminonucleoside (50 mg/kg) 100416puromycin aminonucleoside (50 mg/kg)
10serum albumin levelWKYmale1.4g/dlcontrolled enalapril content drinking water (50 mg/l) (for 30 days) then puromycin aminonucleoside (50 mg/kg) 100417controlled enalapril content drinking water (50 mg/l) (for 30 days)puromycin aminonucleoside (50 mg/kg)
11serum albumin levelWKYmale3.7g/dl0.9% sodium chloride solution (3 ml) 1004180.9% sodium chloride solution (3 ml)
12serum albumin levelWKYmale3.8g/dlpuromycin aminonucleoside (50 mg/kg) 100419puromycin aminonucleoside (50 mg/kg)
12serum albumin levelWKYmale3.6g/dlcontrolled enalapril content drinking water (50 mg/l) (between 63 and 77 days) then puromycin aminonucleoside (50 mg/kg) 100420controlled enalapril content drinking water (50 mg/l) (between 63 and 77 days)puromycin aminonucleoside (50 mg/kg)
10serum triglyceride levelWKYmale61mg/dl0.9% sodium chloride solution (3 ml) 1004090.9% sodium chloride solution (3 ml)
11serum triglyceride levelWKYmale231mg/dlpuromycin aminonucleoside (50 mg/kg) 100410puromycin aminonucleoside (50 mg/kg)
10serum triglyceride levelWKYmale240mg/dlcontrolled enalapril content drinking water (50 mg/l) (for 26 days) then puromycin aminonucleoside (50 mg/kg) 100411controlled enalapril content drinking water (50 mg/l) (for 26 days)puromycin aminonucleoside (50 mg/kg)
11serum triglyceride levelWKYmale55mg/dl0.9% sodium chloride solution (3 ml) 1004120.9% sodium chloride solution (3 ml)
12serum triglyceride levelWKYmale73mg/dlpuromycin aminonucleoside (50 mg/kg) 100413puromycin aminonucleoside (50 mg/kg)
12serum triglyceride levelWKYmale72mg/dlcontrolled enalapril content drinking water (50 mg/l) (between 63 and 77 days) then puromycin aminonucleoside (50 mg/kg) 100414controlled enalapril content drinking water (50 mg/l) (between 63 and 77 days)puromycin aminonucleoside (50 mg/kg)
10serum total cholesterol levelWKYmale65mg/dl0.9% sodium chloride solution (3 ml) 1004030.9% sodium chloride solution (3 ml)
11serum total cholesterol levelWKYmale240mg/dlpuromycin aminonucleoside (50 mg/kg) 100404puromycin aminonucleoside (50 mg/kg)
10serum total cholesterol levelWKYmale360mg/dlcontrolled enalapril content drinking water (50 mg/l) (for 26 days) then puromycin aminonucleoside (50 mg/kg) 100405controlled enalapril content drinking water (50 mg/l) (for 26 days)puromycin aminonucleoside (50 mg/kg)
11serum total cholesterol levelWKYmale73mg/dl0.9% sodium chloride solution (3 ml) 1004060.9% sodium chloride solution (3 ml)
12serum total cholesterol levelWKYmale88mg/dlpuromycin aminonucleoside (50 mg/kg) 100407puromycin aminonucleoside (50 mg/kg)
12serum total cholesterol levelWKYmale104mg/dlcontrolled enalapril content drinking water (50 mg/l) (between 63 and 77 days) then puromycin aminonucleoside (50 mg/kg) 100408controlled enalapril content drinking water (50 mg/l) (between 63 and 77 days)puromycin aminonucleoside (50 mg/kg)
10urine protein excretion rateWKYmale5mg/d0.9% sodium chloride solution (3 ml) 1003970.9% sodium chloride solution (3 ml)
11urine protein excretion rateWKYmale112mg/dpuromycin aminonucleoside (50 mg/kg) 100398puromycin aminonucleoside (50 mg/kg)
10urine protein excretion rateWKYmale115mg/dcontrolled enalapril content drinking water (50 mg/l) (for 22 days) then puromycin aminonucleoside (50 mg/kg) 100399controlled enalapril content drinking water (50 mg/l) (for 22 days)puromycin aminonucleoside (50 mg/kg)
11urine protein excretion rateWKYmale8mg/d0.9% sodium chloride solution (3 ml) 1004000.9% sodium chloride solution (3 ml)
12urine protein excretion rateWKYmale13mg/dpuromycin aminonucleoside (50 mg/kg) 100401puromycin aminonucleoside (50 mg/kg)
12urine protein excretion rateWKYmale10mg/dcontrolled enalapril content drinking water (50 mg/l) (between 63 and 77 days) then puromycin aminonucleoside (50 mg/kg) 100402controlled enalapril content drinking water (50 mg/l) (between 63 and 77 days)puromycin aminonucleoside (50 mg/kg)
11body weightWKYmale249gpuromycin aminonucleoside (50 mg/kg) 100392puromycin aminonucleoside (50 mg/kg)
10body weightWKYmale241gcontrolled enalapril content drinking water (50 mg/l) (for 22 days) then puromycin aminonucleoside (50 mg/kg) 100393controlled enalapril content drinking water (50 mg/l) (for 22 days)puromycin aminonucleoside (50 mg/kg)
9body weightWKYmale244g0.9% sodium chloride solution (3 ml) 1004270.9% sodium chloride solution (3 ml)
7body weightWKYmale245gpuromycin aminonucleoside (50 mg/kg) 100428puromycin aminonucleoside (50 mg/kg)
5body weightWKYmale245gcontrolled enalapril content drinking water (50 mg/l) (for 22 days) then puromycin aminonucleoside (50 mg/kg) 100429controlled enalapril content drinking water (50 mg/l) (for 22 days)puromycin aminonucleoside (50 mg/kg)
8body weightWKYmale317g0.9% sodium chloride solution (3 ml) 1004300.9% sodium chloride solution (3 ml)
9body weightWKYmale297gpuromycin aminonucleoside (50 mg/kg) 100431puromycin aminonucleoside (50 mg/kg)
8body weightWKYmale305gcontrolled enalapril content drinking water (50 mg/l) (between 63 and 77 days) then puromycin aminonucleoside (50 mg/kg) 100432controlled enalapril content drinking water (50 mg/l) (between 63 and 77 days)puromycin aminonucleoside (50 mg/kg)
9body weightWKYmale412g0.9% sodium chloride solution (3 ml) 1004330.9% sodium chloride solution (3 ml)
8body weightWKYmale418gpuromycin aminonucleoside (50 mg/kg) 100434puromycin aminonucleoside (50 mg/kg)
9body weightWKYmale395gcontrolled enalapril content drinking water (50 mg/l) (for 497 days) then puromycin aminonucleoside (50 mg/kg) 100435controlled enalapril content drinking water (50 mg/l) (for 497 days)puromycin aminonucleoside (50 mg/kg)
10body weightWKYmale241g0.9% sodium chloride solution (3 ml) 1003910.9% sodium chloride solution (3 ml)
11body weightWKYmale319g0.9% sodium chloride solution (3 ml) 1003940.9% sodium chloride solution (3 ml)
12body weightWKYmale323gpuromycin aminonucleoside (50 mg/kg) 100395puromycin aminonucleoside (50 mg/kg)
12body weightWKYmale312gcontrolled enalapril content drinking water (50 mg/l) (between 63 and 77 days) then puromycin aminonucleoside (50 mg/kg) 100396controlled enalapril content drinking water (50 mg/l) (between 63 and 77 days)puromycin aminonucleoside (50 mg/kg)
9glomerular capillary hydraulic pressureWKYmale49mmHg0.9% sodium chloride solution (3 ml) 1005320.9% sodium chloride solution (3 ml)
6glomerular capillary hydraulic pressureWKYmale50mmHgpuromycin aminonucleoside (50 mg/kg) 100533puromycin aminonucleoside (50 mg/kg)
8glomerular capillary hydraulic pressureWKYmale47mmHg0.9% sodium chloride solution (3 ml) 1005340.9% sodium chloride solution (3 ml)
9glomerular capillary hydraulic pressureWKYmale68mmHgpuromycin aminonucleoside (50 mg/kg) 100535puromycin aminonucleoside (50 mg/kg)
8glomerular capillary hydraulic pressureWKYmale46mmHgcontrolled enalapril content drinking water (50 mg/l) (for 7 days) then puromycin aminonucleoside (50 mg/kg) 100536controlled enalapril content drinking water (50 mg/l) (for 7 days)puromycin aminonucleoside (50 mg/kg)
9mean proximal tubular hydraulic pressureWKYmale14mmHg0.9% sodium chloride solution (3 ml) 1005370.9% sodium chloride solution (3 ml)
6mean proximal tubular hydraulic pressureWKYmale15mmHgpuromycin aminonucleoside (50 mg/kg) 100538puromycin aminonucleoside (50 mg/kg)
8mean proximal tubular hydraulic pressureWKYmale14mmHg0.9% sodium chloride solution (3 ml) 1005390.9% sodium chloride solution (3 ml)
9mean proximal tubular hydraulic pressureWKYmale19mmHgpuromycin aminonucleoside (50 mg/kg) 100540puromycin aminonucleoside (50 mg/kg)
8mean proximal tubular hydraulic pressureWKYmale16mmHgcontrolled enalapril content drinking water (50 mg/l) (for 7 days) then puromycin aminonucleoside (50 mg/kg) 100541controlled enalapril content drinking water (50 mg/l) (for 7 days)puromycin aminonucleoside (50 mg/kg)
9glomerular transcapillary hydraulic pressure gradientWKYmale35mmHg0.9% sodium chloride solution (3 ml) 1005470.9% sodium chloride solution (3 ml)
6glomerular transcapillary hydraulic pressure gradientWKYmale35mmHgpuromycin aminonucleoside (50 mg/kg) 100548puromycin aminonucleoside (50 mg/kg)
8glomerular transcapillary hydraulic pressure gradientWKYmale33mmHg0.9% sodium chloride solution (3 ml) 1005490.9% sodium chloride solution (3 ml)
9glomerular transcapillary hydraulic pressure gradientWKYmale48mmHgpuromycin aminonucleoside (50 mg/kg) 100550puromycin aminonucleoside (50 mg/kg)
8glomerular transcapillary hydraulic pressure gradientWKYmale31mmHgcontrolled enalapril content drinking water (50 mg/l) (for 7 days) then puromycin aminonucleoside (50 mg/kg) 100551controlled enalapril content drinking water (50 mg/l) (for 7 days)puromycin aminonucleoside (50 mg/kg)
9afferent colloid osmotic pressureWKYmale18.1mmHg0.9% sodium chloride solution (3 ml) 1005770.9% sodium chloride solution (3 ml)
6afferent colloid osmotic pressureWKYmale12mmHgpuromycin aminonucleoside (50 mg/kg) 100578puromycin aminonucleoside (50 mg/kg)
8afferent colloid osmotic pressureWKYmale18mmHg0.9% sodium chloride solution (3 ml) 1005790.9% sodium chloride solution (3 ml)
9afferent colloid osmotic pressureWKYmale18mmHgpuromycin aminonucleoside (50 mg/kg) 100580puromycin aminonucleoside (50 mg/kg)
8afferent colloid osmotic pressureWKYmale18mmHgcontrolled enalapril content drinking water (50 mg/l) (for 7 days) then puromycin aminonucleoside (50 mg/kg) 100581controlled enalapril content drinking water (50 mg/l) (for 7 days)puromycin aminonucleoside (50 mg/kg)
9efferent colloid osmotic pressureWKYmale29mmHg0.9% sodium chloride solution (3 ml) 1005820.9% sodium chloride solution (3 ml)
6efferent colloid osmotic pressureWKYmale14mmHgpuromycin aminonucleoside (50 mg/kg) 100583puromycin aminonucleoside (50 mg/kg)
8efferent colloid osmotic pressureWKYmale31mmHg0.9% sodium chloride solution (3 ml) 1005840.9% sodium chloride solution (3 ml)
9efferent colloid osmotic pressureWKYmale33mmHgpuromycin aminonucleoside (50 mg/kg) 100585puromycin aminonucleoside (50 mg/kg)
8efferent colloid osmotic pressureWKYmale29mmHgcontrolled enalapril content drinking water (50 mg/l) (for 7 days) then puromycin aminonucleoside (50 mg/kg) 100586controlled enalapril content drinking water (50 mg/l) (for 7 days)puromycin aminonucleoside (50 mg/kg)
9glomerular capillary ultrafiltration coefficientWKYmale0.073nl/(s x mmHg)0.9% sodium chloride solution (3 ml) 1005870.9% sodium chloride solution (3 ml)
6glomerular capillary ultrafiltration coefficientWKYmale0.015nl/(s x mmHg)puromycin aminonucleoside (50 mg/kg) 100588puromycin aminonucleoside (50 mg/kg)
8glomerular capillary ultrafiltration coefficientWKYmale0.092nl/(s x mmHg)0.9% sodium chloride solution (3 ml) 1005890.9% sodium chloride solution (3 ml)
9glomerular capillary ultrafiltration coefficientWKYmale0.039nl/(s x mmHg)puromycin aminonucleoside (50 mg/kg) 100590puromycin aminonucleoside (50 mg/kg)
8glomerular capillary ultrafiltration coefficientWKYmale0.108nl/(s x mmHg)controlled enalapril content drinking water (50 mg/l) (for 7 days) then puromycin aminonucleoside (50 mg/kg) 100591controlled enalapril content drinking water (50 mg/l) (for 7 days)puromycin aminonucleoside (50 mg/kg)
5glomerular capillary hydraulic pressureWKYmale62mmHgpuromycin aminonucleoside (50 mg/kg) 100614puromycin aminonucleoside (50 mg/kg)
5glomerular capillary hydraulic pressureWKYmale51mmHgpuromycin aminonucleoside (50 mg/kg) (between 56 and 70 days) then saralasin (0.3 mg/kg/hr) (for 0.5 hours)100615puromycin aminonucleoside (50 mg/kg) (between 56 and 70 days)saralasin (0.3 mg/kg/hr) (for 0.5 hours)
9efferent arteriolar hydraulic pressureWKYmale22mmHgpuromycin aminonucleoside (50 mg/kg) 109968puromycin aminonucleoside (50 mg/kg)
9efferent arteriolar hydraulic pressureWKYmale18mmHg0.9% sodium chloride solution (3 ml) 1099650.9% sodium chloride solution (3 ml)
6efferent arteriolar hydraulic pressureWKYmale21mmHgpuromycin aminonucleoside (50 mg/kg) 109966puromycin aminonucleoside (50 mg/kg)
8efferent arteriolar hydraulic pressureWKYmale17mmHg0.9% sodium chloride solution (3 ml) 1099670.9% sodium chloride solution (3 ml)
8efferent arteriolar hydraulic pressureWKYmale24mmHgenalapril (50 mg/l) (for 7 days) then puromycin aminonucleoside (50 mg/kg) 109969enalapril (50 mg/l) (for 7 days)puromycin aminonucleoside (50 mg/kg)
17heart weight to body weight ratioWKYmale3.5g/kgunilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then vehicle control condition107451unilateral nephrectomy (for 150 days)streptozotocin (35 mg/kg) vehicle control condition
16heart weight to body weight ratioWKYmale3.1g/kgunilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 136 days)107453unilateral nephrectomy (for 150 days)streptozotocin (35 mg/kg) enalapril (10 mg/kg/d) (for 136 days)
11heart weight to body weight ratioWKYmale2.4g/kgunilateral nephrectomy (for 150 days) then vehicle control condition107450unilateral nephrectomy (for 150 days)vehicle control condition
17heart weight to body weight ratioWKYmale3.2g/kgunilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then bosentan (100 mg/kg/d) (for 136 days)107452unilateral nephrectomy (for 150 days)streptozotocin (35 mg/kg) bosentan (100 mg/kg/d) (for 136 days)
16heart weight to body weight ratioWKYmale3.1g/kgunilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 136 days) and bosentan (100 mg/kg/d) (for 136 days)107454unilateral nephrectomy (for 150 days)streptozotocin (35 mg/kg) enalapril (10 mg/kg/d) (for 136 days)bosentan (100 mg/kg/d) (for 136 days)
17kidney glomerular tuft surface areaWKYmale13.2x 10E3 um2unilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then vehicle control condition107511unilateral nephrectomy (for 150 days)streptozotocin (35 mg/kg) vehicle control condition
17kidney glomerular tuft surface areaWKYmale11.8x 10E3 um2unilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then bosentan (100 mg/kg/d) (for 136 days)107512unilateral nephrectomy (for 150 days)streptozotocin (35 mg/kg) bosentan (100 mg/kg/d) (for 136 days)
16kidney glomerular tuft surface areaWKYmale11.7x 10E3 um2unilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 136 days) and bosentan (100 mg/kg/d) (for 136 days)107514unilateral nephrectomy (for 150 days)streptozotocin (35 mg/kg) enalapril (10 mg/kg/d) (for 136 days)bosentan (100 mg/kg/d) (for 136 days)
16kidney glomerular surface areaWKYmale16.4x 10E3 um2unilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 136 days) and bosentan (100 mg/kg/d) (for 136 days)107464unilateral nephrectomy (for 150 days)streptozotocin (35 mg/kg) enalapril (10 mg/kg/d) (for 136 days)bosentan (100 mg/kg/d) (for 136 days)
17kidney glomerular surface areaWKYmale19.3x 10E3 um2unilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then vehicle control condition107461unilateral nephrectomy (for 150 days)streptozotocin (35 mg/kg) vehicle control condition
11kidney glomerular tuft surface areaWKYmale8.7x 10E3 um2unilateral nephrectomy (for 150 days) then vehicle control condition107510unilateral nephrectomy (for 150 days)vehicle control condition
16kidney glomerular tuft surface areaWKYmale11.1x 10E3 um2unilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 136 days)107513unilateral nephrectomy (for 150 days)streptozotocin (35 mg/kg) enalapril (10 mg/kg/d) (for 136 days)
11kidney glomerular surface areaWKYmale12.6x 10E3 um2unilateral nephrectomy (for 150 days) then vehicle control condition107460unilateral nephrectomy (for 150 days)vehicle control condition
17kidney glomerular surface areaWKYmale17x 10E3 um2unilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then bosentan (100 mg/kg/d) (for 136 days)107462unilateral nephrectomy (for 150 days)streptozotocin (35 mg/kg) bosentan (100 mg/kg/d) (for 136 days)
16kidney glomerular surface areaWKYmale15.8x 10E3 um2unilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 136 days)107463unilateral nephrectomy (for 150 days)streptozotocin (35 mg/kg) enalapril (10 mg/kg/d) (for 136 days)
17left kidney wet weight to body weight ratioWKYmale9.9mg/gunilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then vehicle control condition107456unilateral nephrectomy (for 150 days)streptozotocin (35 mg/kg) vehicle control condition
17left kidney wet weight to body weight ratioWKYmale8.2mg/gunilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then bosentan (100 mg/kg/d) (for 136 days)107457unilateral nephrectomy (for 150 days)streptozotocin (35 mg/kg) bosentan (100 mg/kg/d) (for 136 days)
16left kidney wet weight to body weight ratioWKYmale8.1mg/gunilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 136 days)107458unilateral nephrectomy (for 150 days)streptozotocin (35 mg/kg) enalapril (10 mg/kg/d) (for 136 days)
16left kidney wet weight to body weight ratioWKYmale8.3mg/gunilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 136 days) and bosentan (100 mg/kg/d) (for 136 days)107459unilateral nephrectomy (for 150 days)streptozotocin (35 mg/kg) enalapril (10 mg/kg/d) (for 136 days)bosentan (100 mg/kg/d) (for 136 days)
11left kidney wet weight to body weight ratioWKYmale3.9mg/gunilateral nephrectomy (for 150 days) then vehicle control condition107455unilateral nephrectomy (for 150 days)vehicle control condition
11renal vascular resistanceWKYmale6.3mmHg/ml/minunilateral nephrectomy (for 28 days) then vehicle control condition99995unilateral nephrectomy (for 28 days)vehicle control condition
17renal vascular resistanceWKYmale16.7mmHg/ml/minunilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then vehicle control condition99996unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) vehicle control condition
17renal vascular resistanceWKYmale6.6mmHg/ml/minunilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then bosentan (100 mg/kg/d) (for 154 days)99997unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) bosentan (100 mg/kg/d) (for 154 days)
16renal vascular resistanceWKYmale7.1mmHg/ml/minunilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 154 days)99998unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) enalapril (10 mg/kg/d) (for 154 days)
16renal vascular resistanceWKYmale6.8mmHg/ml/minunilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 154 days) and bosentan (100 mg/kg/d) (for 154 days)99999unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) enalapril (10 mg/kg/d) (for 154 days)bosentan (100 mg/kg/d) (for 154 days)
7renal vascular resistanceWKYmale10mmHg/ml/minunilateral nephrectomy (for 28 days) then vehicle control condition99960unilateral nephrectomy (for 28 days)vehicle control condition
8renal vascular resistanceWKYmale9mmHg/ml/minunilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then vehicle control condition99961unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) vehicle control condition
8renal vascular resistanceWKYmale8.8mmHg/ml/minunilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then bosentan (100 mg/kg/d) (for 14 days)99962unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) bosentan (100 mg/kg/d) (for 14 days)
8renal vascular resistanceWKYmale9.2mmHg/ml/minunilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 14 days)99963unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) enalapril (10 mg/kg/d) (for 14 days)
6renal vascular resistanceWKYmale8.8mmHg/ml/minunilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 14 days) and bosentan (100 mg/kg/d) (for 14 days)99964unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) enalapril (10 mg/kg/d) (for 14 days)bosentan (100 mg/kg/d) (for 14 days)
11renal plasma flow to body weight ratioWKYmale2.28ml/min/100gunilateral nephrectomy (for 28 days) then vehicle control condition99990unilateral nephrectomy (for 28 days)vehicle control condition
17renal plasma flow to body weight ratioWKYmale1.72ml/min/100gunilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then vehicle control condition99991unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) vehicle control condition
17renal plasma flow to body weight ratioWKYmale3.3ml/min/100gunilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then bosentan (100 mg/kg/d) (for 154 days)99992unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) bosentan (100 mg/kg/d) (for 154 days)
16renal plasma flow to body weight ratioWKYmale3.15ml/min/100gunilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 154 days)99993unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) enalapril (10 mg/kg/d) (for 154 days)
16renal plasma flow to body weight ratioWKYmale3.19ml/min/100gunilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 154 days) and bosentan (100 mg/kg/d) (for 154 days)99994unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) enalapril (10 mg/kg/d) (for 154 days)bosentan (100 mg/kg/d) (for 154 days)
7renal plasma flow to body weight ratioWKYmale2.16ml/min/100gunilateral nephrectomy (for 28 days) then vehicle control condition99950unilateral nephrectomy (for 28 days)vehicle control condition
8renal plasma flow to body weight ratioWKYmale3.09ml/min/100gunilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then vehicle control condition99951unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) vehicle control condition
8renal plasma flow to body weight ratioWKYmale2.33ml/min/100gunilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then bosentan (100 mg/kg/d) (for 14 days)99952unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) bosentan (100 mg/kg/d) (for 14 days)
8renal plasma flow to body weight ratioWKYmale2.32ml/min/100gunilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 14 days)99953unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) enalapril (10 mg/kg/d) (for 14 days)
6renal plasma flow to body weight ratioWKYmale2.42ml/min/100gunilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 14 days) and bosentan (100 mg/kg/d) (for 14 days)99954unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) enalapril (10 mg/kg/d) (for 14 days)bosentan (100 mg/kg/d) (for 14 days)
11timed urine volumeWKYmale11.664ml/dunilateral nephrectomy (for 28 days) then vehicle control condition100000unilateral nephrectomy (for 28 days)vehicle control condition
17timed urine volumeWKYmale39.456ml/dunilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then vehicle control condition100001unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) vehicle control condition
17timed urine volumeWKYmale41.472ml/dunilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then bosentan (100 mg/kg/d) (for 154 days)100002unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) bosentan (100 mg/kg/d) (for 154 days)
16timed urine volumeWKYmale45.504ml/dunilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 154 days)100003unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) enalapril (10 mg/kg/d) (for 154 days)
16timed urine volumeWKYmale49.248ml/dunilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 154 days) and bosentan (100 mg/kg/d) (for 154 days)100004unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) enalapril (10 mg/kg/d) (for 154 days)bosentan (100 mg/kg/d) (for 154 days)
7timed urine volumeWKYmale12.384ml/dunilateral nephrectomy (for 28 days) then vehicle control condition99965unilateral nephrectomy (for 28 days)vehicle control condition
8timed urine volumeWKYmale23.472ml/dunilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then vehicle control condition99966unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) vehicle control condition
8timed urine volumeWKYmale38.016ml/dunilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then bosentan (100 mg/kg/d) (for 14 days)99967unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) bosentan (100 mg/kg/d) (for 14 days)
8timed urine volumeWKYmale41.616ml/dunilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 14 days)99968unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) enalapril (10 mg/kg/d) (for 14 days)
6timed urine volumeWKYmale44.928ml/dunilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 14 days) and bosentan (100 mg/kg/d) (for 14 days)99969unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) enalapril (10 mg/kg/d) (for 14 days)bosentan (100 mg/kg/d) (for 14 days)
11blood glucose levelWKYmale76mg/dlunilateral nephrectomy (for 28 days) then vehicle control condition99970unilateral nephrectomy (for 28 days)vehicle control condition
17blood glucose levelWKYmale324mg/dlunilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then vehicle control condition99971unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) vehicle control condition
17blood glucose levelWKYmale312mg/dlunilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then bosentan (100 mg/kg/d) (for 154 days)99972unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) bosentan (100 mg/kg/d) (for 154 days)
16blood glucose levelWKYmale308mg/dlunilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 154 days)99973unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) enalapril (10 mg/kg/d) (for 154 days)
16blood glucose levelWKYmale317mg/dlunilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 154 days) and bosentan (100 mg/kg/d) (for 154 days)99974unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) enalapril (10 mg/kg/d) (for 154 days)bosentan (100 mg/kg/d) (for 154 days)
7blood glucose levelWKYmale74mg/dlunilateral nephrectomy (for 28 days) then vehicle control condition99940unilateral nephrectomy (for 28 days)vehicle control condition
8blood glucose levelWKYmale350mg/dlunilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then vehicle control condition99941unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) vehicle control condition
8blood glucose levelWKYmale352mg/dlunilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then bosentan (100 mg/kg/d) (for 14 days)99942unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) bosentan (100 mg/kg/d) (for 14 days)
8blood glucose levelWKYmale357mg/dlunilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 14 days)99943unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) enalapril (10 mg/kg/d) (for 14 days)
6blood glucose levelWKYmale367mg/dlunilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 14 days) and bosentan (100 mg/kg/d) (for 14 days)99944unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) enalapril (10 mg/kg/d) (for 14 days)bosentan (100 mg/kg/d) (for 14 days)
7body weightWKYmale268gunilateral nephrectomy (for 28 days) then vehicle control condition99935unilateral nephrectomy (for 28 days)vehicle control condition
8body weightWKYmale215gunilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then vehicle control condition99936unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) vehicle control condition
8body weightWKYmale236gunilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then bosentan (100 mg/kg/d) (for 14 days)99937unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) bosentan (100 mg/kg/d) (for 14 days)
8body weightWKYmale233gunilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 14 days)99938unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) enalapril (10 mg/kg/d) (for 14 days)
6body weightWKYmale229gunilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 14 days) and bosentan (100 mg/kg/d) (for 14 days)99939unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) enalapril (10 mg/kg/d) (for 14 days)bosentan (100 mg/kg/d) (for 14 days)
17body weightWKYmale256gunilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then vehicle control condition107446unilateral nephrectomy (for 150 days)streptozotocin (35 mg/kg) vehicle control condition
17body weightWKYmale274gunilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then bosentan (100 mg/kg/d) (for 136 days)107447unilateral nephrectomy (for 150 days)streptozotocin (35 mg/kg) bosentan (100 mg/kg/d) (for 136 days)
11body weightWKYmale408gunilateral nephrectomy (for 150 days) then vehicle control condition107445unilateral nephrectomy (for 150 days)vehicle control condition
16body weightWKYmale267gunilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 136 days) and bosentan (100 mg/kg/d) (for 136 days)107449unilateral nephrectomy (for 150 days)streptozotocin (35 mg/kg) enalapril (10 mg/kg/d) (for 136 days)bosentan (100 mg/kg/d) (for 136 days)
16body weightWKYmale261gunilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 136 days)107448unilateral nephrectomy (for 150 days)streptozotocin (35 mg/kg) enalapril (10 mg/kg/d) (for 136 days)
11glomerular filtration rate to body weight ratioWKYmale0.517ml/min/100gunilateral nephrectomy (for 28 days) then vehicle control condition99980unilateral nephrectomy (for 28 days)vehicle control condition
17glomerular filtration rate to body weight ratioWKYmale0.496ml/min/100gunilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then vehicle control condition99981unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) vehicle control condition
17glomerular filtration rate to body weight ratioWKYmale0.69ml/min/100gunilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then bosentan (100 mg/kg/d) (for 154 days)99982unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) bosentan (100 mg/kg/d) (for 154 days)
16glomerular filtration rate to body weight ratioWKYmale0.664ml/min/100gunilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 154 days)99983unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) enalapril (10 mg/kg/d) (for 154 days)
16glomerular filtration rate to body weight ratioWKYmale0.673ml/min/100gunilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 154 days) and bosentan (100 mg/kg/d) (for 154 days)99984unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) enalapril (10 mg/kg/d) (for 154 days)bosentan (100 mg/kg/d) (for 154 days)
11renal filtration fractionWKYmale0.23unilateral nephrectomy (for 28 days) then vehicle control condition99985unilateral nephrectomy (for 28 days)vehicle control condition
17renal filtration fractionWKYmale0.293unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then vehicle control condition99986unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) vehicle control condition
17renal filtration fractionWKYmale0.214unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then bosentan (100 mg/kg/d) (for 154 days)99987unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) bosentan (100 mg/kg/d) (for 154 days)
16renal filtration fractionWKYmale0.216unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 154 days)99988unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) enalapril (10 mg/kg/d) (for 154 days)
16renal filtration fractionWKYmale0.213unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 154 days) and bosentan (100 mg/kg/d) (for 154 days)99989unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) enalapril (10 mg/kg/d) (for 154 days)bosentan (100 mg/kg/d) (for 154 days)
7glomerular filtration rate to body weight ratioWKYmale0.494ml/min/100gunilateral nephrectomy (for 28 days) then vehicle control condition99945unilateral nephrectomy (for 28 days)vehicle control condition
8glomerular filtration rate to body weight ratioWKYmale0.792ml/min/100gunilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then vehicle control condition99946unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) vehicle control condition
8glomerular filtration rate to body weight ratioWKYmale0.516ml/min/100gunilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then bosentan (100 mg/kg/d) (for 14 days)99947unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) bosentan (100 mg/kg/d) (for 14 days)
8glomerular filtration rate to body weight ratioWKYmale0.536ml/min/100gunilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 14 days)99948unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) enalapril (10 mg/kg/d) (for 14 days)
6glomerular filtration rate to body weight ratioWKYmale0.504ml/min/100gunilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 14 days) and bosentan (100 mg/kg/d) (for 14 days)99949unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) enalapril (10 mg/kg/d) (for 14 days)bosentan (100 mg/kg/d) (for 14 days)
7renal filtration fractionWKYmale0.233unilateral nephrectomy (for 28 days) then vehicle control condition99955unilateral nephrectomy (for 28 days)vehicle control condition
8renal filtration fractionWKYmale0.26unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then vehicle control condition99956unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) vehicle control condition
8renal filtration fractionWKYmale0.233unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then bosentan (100 mg/kg/d) (for 14 days)99957unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) bosentan (100 mg/kg/d) (for 14 days)
8renal filtration fractionWKYmale0.234unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 14 days)99958unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) enalapril (10 mg/kg/d) (for 14 days)
6renal filtration fractionWKYmale0.21unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 14 days) and bosentan (100 mg/kg/d) (for 14 days)99959unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) enalapril (10 mg/kg/d) (for 14 days)bosentan (100 mg/kg/d) (for 14 days)
11hematocritWKYmale45.2%unilateral nephrectomy (for 28 days) then vehicle control condition99975unilateral nephrectomy (for 28 days)vehicle control condition
17hematocritWKYmale44.8%unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then vehicle control condition99976unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) vehicle control condition
17hematocritWKYmale45.6%unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then bosentan (100 mg/kg/d) (for 154 days)99977unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) bosentan (100 mg/kg/d) (for 154 days)
16hematocritWKYmale45.8%unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 154 days)99978unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) enalapril (10 mg/kg/d) (for 154 days)
16hematocritWKYmale44.5%unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 154 days) and bosentan (100 mg/kg/d) (for 154 days)99979unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) enalapril (10 mg/kg/d) (for 154 days)bosentan (100 mg/kg/d) (for 154 days)
7blood urea nitrogen levelWKYmale19.5mg/dlnaive control condition99857naive control condition
7heart weight to body weight ratioWKYmale3.7g/kgnaive control condition99853naive control condition
7body weightWKYmale373.6gnaive control condition99849naive control condition
12heart ventricle septal wall thicknessWKYmale0.14cmsham surgical control condition (for 196 days)100336sham surgical control condition (for 196 days)
20heart ventricle septal wall thicknessWKYmale0.13cmleft anterior descending coronary artery occlusion (for 196 days) then furosemide (10 ml/kg/d) (for 182 days)100337left anterior descending coronary artery occlusion (for 196 days)furosemide (10 ml/kg/d) (for 182 days)
30heart ventricle septal wall thicknessWKYmale0.1cmleft anterior descending coronary artery occlusion (for 196 days) then vehicle control condition (for 182 days)100338left anterior descending coronary artery occlusion (for 196 days)vehicle control condition (for 182 days)
12heart posterior wall thicknessWKYmale0.17cmsham surgical control condition (for 196 days)100345sham surgical control condition (for 196 days)
20heart posterior wall thicknessWKYmale0.17cmleft anterior descending coronary artery occlusion (for 196 days) then furosemide (10 ml/kg/d) (for 182 days)100346left anterior descending coronary artery occlusion (for 196 days)furosemide (10 ml/kg/d) (for 182 days)
30heart posterior wall thicknessWKYmale0.18cmleft anterior descending coronary artery occlusion (for 196 days) then vehicle control condition (for 182 days)100347left anterior descending coronary artery occlusion (for 196 days)vehicle control condition (for 182 days)
5heart left ventricle fractional shorteningWKYmale51.5%sham surgical control condition (for 224 days)100303sham surgical control condition (for 224 days)
16heart left ventricle fractional shorteningWKYmale16.8%left anterior descending coronary artery occlusion (for 224 days) then furosemide (10 mg/kg/d) (for 161 days)100304left anterior descending coronary artery occlusion (for 224 days)furosemide (10 mg/kg/d) (for 161 days)
32heart left ventricle fractional shorteningWKYmale18%left anterior descending coronary artery occlusion (for 224 days) then furosemide (10 mg/kg/d) (for 161 days) then ramipril (1 mg/kg/d) (for 182 days)100305left anterior descending coronary artery occlusion (for 224 days)furosemide (10 mg/kg/d) (for 161 days)ramipril (1 mg/kg/d) (for 182 days)
5heart left ventricular end-diastolic diameterWKYmale7.9mmsham surgical control condition (for 224 days)100306sham surgical control condition (for 224 days)
16heart left ventricular end-diastolic diameterWKYmale10.8mmleft anterior descending coronary artery occlusion (for 224 days) then furosemide (10 mg/kg/d) (for 161 days)100307left anterior descending coronary artery occlusion (for 224 days)furosemide (10 mg/kg/d) (for 161 days)
32heart left ventricular end-diastolic diameterWKYmale10.6mmleft anterior descending coronary artery occlusion (for 224 days) then furosemide (10 mg/kg/d) (for 161 days) then ramipril (1 mg/kg/d) (for 182 days)100308left anterior descending coronary artery occlusion (for 224 days)furosemide (10 mg/kg/d) (for 161 days)ramipril (1 mg/kg/d) (for 182 days)
5heart left ventricle end-systolic diameterWKYmale3.8mmsham surgical control condition (for 224 days)100309sham surgical control condition (for 224 days)
16heart left ventricle end-systolic diameterWKYmale9.1mmleft anterior descending coronary artery occlusion (for 224 days) then furosemide (10 mg/kg/d) (for 161 days)100310left anterior descending coronary artery occlusion (for 224 days)furosemide (10 mg/kg/d) (for 161 days)
32heart left ventricle end-systolic diameterWKYmale8.8mmleft anterior descending coronary artery occlusion (for 224 days) then furosemide (10 mg/kg/d) (for 161 days) then ramipril (1 mg/kg/d) (for 182 days)100311left anterior descending coronary artery occlusion (for 224 days)furosemide (10 mg/kg/d) (for 161 days)ramipril (1 mg/kg/d) (for 182 days)
12heart left ventricular end-diastolic diameterWKYmale8.3mmsham surgical control condition (for 196 days)100339sham surgical control condition (for 196 days)
20heart left ventricular end-diastolic diameterWKYmale10.6mmleft anterior descending coronary artery occlusion (for 196 days) then furosemide (10 ml/kg/d) (for 182 days)100340left anterior descending coronary artery occlusion (for 196 days)furosemide (10 ml/kg/d) (for 182 days)
30heart left ventricular end-diastolic diameterWKYmale10.6mmleft anterior descending coronary artery occlusion (for 196 days) then vehicle control condition (for 182 days)100341left anterior descending coronary artery occlusion (for 196 days)vehicle control condition (for 182 days)
12heart left ventricle end-systolic diameterWKYmale4.9mmsham surgical control condition (for 196 days)100342sham surgical control condition (for 196 days)
20heart left ventricle end-systolic diameterWKYmale9mmleft anterior descending coronary artery occlusion (for 196 days) then furosemide (10 ml/kg/d) (for 182 days)100343left anterior descending coronary artery occlusion (for 196 days)furosemide (10 ml/kg/d) (for 182 days)
30heart left ventricle end-systolic diameterWKYmale8.9mmleft anterior descending coronary artery occlusion (for 196 days) then vehicle control condition (for 182 days)100344left anterior descending coronary artery occlusion (for 196 days)vehicle control condition (for 182 days)
12heart left ventricle fractional shorteningWKYmale41.1%sham surgical control condition (for 196 days)100348sham surgical control condition (for 196 days)
20heart left ventricle fractional shorteningWKYmale15.1%left anterior descending coronary artery occlusion (for 196 days) then furosemide (10 ml/kg/d) (for 182 days)100349left anterior descending coronary artery occlusion (for 196 days)furosemide (10 ml/kg/d) (for 182 days)
30heart left ventricle fractional shorteningWKYmale15.8%left anterior descending coronary artery occlusion (for 196 days) then vehicle control condition (for 182 days)100350left anterior descending coronary artery occlusion (for 196 days)vehicle control condition (for 182 days)
5left ventricular end-systolic blood pressureWKYmale93mmHgsham surgical control condition (for 224 days) then ketamine (80 mg/kg) then xylazine (10 mg/kg) 100321sham surgical control condition (for 224 days)ketamine (80 mg/kg) xylazine (10 mg/kg)
16left ventricular end-systolic blood pressureWKYmale73.5mmHgleft anterior descending coronary artery occlusion (for 224 days) then furosemide (10 mg/kg/d) (for 161 days) then ketamine (80 mg/kg) then xylazine (10 mg/kg) 100322left anterior descending coronary artery occlusion (for 224 days)furosemide (10 mg/kg/d) (for 161 days)ketamine (80 mg/kg) xylazine (10 mg/kg)
32left ventricular end-systolic blood pressureWKYmale67.5mmHgleft anterior descending coronary artery occlusion (for 224 days) then furosemide (10 mg/kg/d) (for 161 days) then ramipril (1 mg/kg/d) (for 182 days) then ketamine (80 mg/kg) then xylazine (10 mg/kg) 100323left anterior descending coronary artery occlusion (for 224 days)furosemide (10 mg/kg/d) (for 161 days)ramipril (1 mg/kg/d) (for 182 days)ketamine (80 mg/kg) xylazine (10 mg/kg)
5left ventricular end-diastolic blood pressureWKYmale5.5mmHgsham surgical control condition (for 224 days) then ketamine (80 mg/kg) then xylazine (10 mg/kg) 100324sham surgical control condition (for 224 days)ketamine (80 mg/kg) xylazine (10 mg/kg)
16left ventricular end-diastolic blood pressureWKYmale9.36mmHgleft anterior descending coronary artery occlusion (for 224 days) then furosemide (10 mg/kg/d) (for 161 days) then ketamine (80 mg/kg) then xylazine (10 mg/kg) 100325left anterior descending coronary artery occlusion (for 224 days)furosemide (10 mg/kg/d) (for 161 days)ketamine (80 mg/kg) xylazine (10 mg/kg)
32left ventricular end-diastolic blood pressureWKYmale5.96mmHgleft anterior descending coronary artery occlusion (for 224 days) then furosemide (10 mg/kg/d) (for 161 days) then ramipril (1 mg/kg/d) (for 182 days) then ketamine (80 mg/kg) then xylazine (10 mg/kg) 100326left anterior descending coronary artery occlusion (for 224 days)furosemide (10 mg/kg/d) (for 161 days)ramipril (1 mg/kg/d) (for 182 days)ketamine (80 mg/kg) xylazine (10 mg/kg)
5maximum rate of positive change in left ventricular blood pressureWKYmale4225mmHg/ssham surgical control condition (for 224 days) then ketamine (80 mg/kg) then xylazine (10 mg/kg) 100327sham surgical control condition (for 224 days)ketamine (80 mg/kg) xylazine (10 mg/kg)
16maximum rate of positive change in left ventricular blood pressureWKYmale2912mmHg/sleft anterior descending coronary artery occlusion (for 224 days) then furosemide (10 mg/kg/d) (for 161 days) then ketamine (80 mg/kg) then xylazine (10 mg/kg) 100328left anterior descending coronary artery occlusion (for 224 days)furosemide (10 mg/kg/d) (for 161 days)ketamine (80 mg/kg) xylazine (10 mg/kg)
32maximum rate of positive change in left ventricular blood pressureWKYmale2882mmHg/sleft anterior descending coronary artery occlusion (for 224 days) then furosemide (10 mg/kg/d) (for 161 days) then ramipril (1 mg/kg/d) (for 182 days) then ketamine (80 mg/kg) then xylazine (10 mg/kg) 100329left anterior descending coronary artery occlusion (for 224 days)furosemide (10 mg/kg/d) (for 161 days)ramipril (1 mg/kg/d) (for 182 days)ketamine (80 mg/kg) xylazine (10 mg/kg)
11artery tunica media width to artery inner diameter ratioWKYmale1.89sham surgical control condition (for 196 days)100386sham surgical control condition (for 196 days)
15artery tunica media width to artery inner diameter ratioWKYmale1.56left anterior descending coronary artery occlusion (for 196 days) then furosemide (10 ml/kg/d) (for 182 days)100387left anterior descending coronary artery occlusion (for 196 days)furosemide (10 ml/kg/d) (for 182 days)
15artery tunica media width to artery inner diameter ratioWKYmale1.82left anterior descending coronary artery occlusion (for 196 days) then vehicle control condition (for 182 days)100388left anterior descending coronary artery occlusion (for 196 days)vehicle control condition (for 182 days)
11index of glomerular damageWKYmale1.39sham surgical control condition (for 196 days)100366sham surgical control condition (for 196 days)
15index of glomerular damageWKYmale1.75left anterior descending coronary artery occlusion (for 196 days) then furosemide (10 ml/kg/d) (for 182 days)100367left anterior descending coronary artery occlusion (for 196 days)furosemide (10 ml/kg/d) (for 182 days)
15index of glomerular damageWKYmale1.6left anterior descending coronary artery occlusion (for 196 days) then vehicle control condition (for 182 days)100368left anterior descending coronary artery occlusion (for 196 days)vehicle control condition (for 182 days)
11kidney fibrotic lesion area to total kidney area ratioWKYmale0.91%sham surgical control condition (for 196 days)100383sham surgical control condition (for 196 days)
15kidney fibrotic lesion area to total kidney area ratioWKYmale0.48%left anterior descending coronary artery occlusion (for 196 days) then furosemide (10 ml/kg/d) (for 182 days)100384left anterior descending coronary artery occlusion (for 196 days)furosemide (10 ml/kg/d) (for 182 days)
15kidney fibrotic lesion area to total kidney area ratioWKYmale0.75%left anterior descending coronary artery occlusion (for 196 days) then vehicle control condition (for 182 days)100385left anterior descending coronary artery occlusion (for 196 days)vehicle control condition (for 182 days)
6plasma creatinine levelWKYmale0.41mg/dlsham surgical control condition (for 196 days)100377sham surgical control condition (for 196 days)
6plasma creatinine levelWKYmale0.47mg/dlleft anterior descending coronary artery occlusion (for 196 days) then furosemide (10 ml/kg/d) (for 182 days)100378left anterior descending coronary artery occlusion (for 196 days)furosemide (10 ml/kg/d) (for 182 days)
6plasma creatinine levelWKYmale0.52mg/dlleft anterior descending coronary artery occlusion (for 196 days) then vehicle control condition (for 182 days)100379left anterior descending coronary artery occlusion (for 196 days)vehicle control condition (for 182 days)
6plasma creatinine levelWKYmale0.41mg/dlsham surgical control condition (for 196 days)100363sham surgical control condition (for 196 days)
6plasma creatinine levelWKYmale0.47mg/dlleft anterior descending coronary artery occlusion (for 196 days) then furosemide (10 ml/kg/d) (for 182 days)100364left anterior descending coronary artery occlusion (for 196 days)furosemide (10 ml/kg/d) (for 182 days)
6plasma creatinine levelWKYmale0.52mg/dlleft anterior descending coronary artery occlusion (for 196 days) then vehicle control condition (for 182 days)100365left anterior descending coronary artery occlusion (for 196 days)vehicle control condition (for 182 days)
7timed urine volumeWKYmale13.9ml/dsham surgical control condition (for 196 days)100374sham surgical control condition (for 196 days)
7timed urine volumeWKYmale11.4ml/dleft anterior descending coronary artery occlusion (for 196 days) then furosemide (10 ml/kg/d) (for 182 days)100375left anterior descending coronary artery occlusion (for 196 days)furosemide (10 ml/kg/d) (for 182 days)
7timed urine volumeWKYmale10.6ml/dleft anterior descending coronary artery occlusion (for 196 days) then vehicle control condition (for 182 days)100376left anterior descending coronary artery occlusion (for 196 days)vehicle control condition (for 182 days)
7timed urine volumeWKYmale13.9ml/dsham surgical control condition (for 196 days)100360sham surgical control condition (for 196 days)
7timed urine volumeWKYmale11.4ml/dleft anterior descending coronary artery occlusion (for 196 days) then furosemide (10 ml/kg/d) (for 182 days)100361left anterior descending coronary artery occlusion (for 196 days)furosemide (10 ml/kg/d) (for 182 days)
7timed urine volumeWKYmale10.6ml/dleft anterior descending coronary artery occlusion (for 196 days) then vehicle control condition (for 182 days)100362left anterior descending coronary artery occlusion (for 196 days)vehicle control condition (for 182 days)
12right kidney wet weightWKYmale1.378gsham surgical control condition (for 196 days)100371sham surgical control condition (for 196 days)
15right kidney wet weightWKYmale1.3715gleft anterior descending coronary artery occlusion (for 196 days) then furosemide (10 ml/kg/d) (for 182 days)100372left anterior descending coronary artery occlusion (for 196 days)furosemide (10 ml/kg/d) (for 182 days)
15right kidney wet weightWKYmale1.3533gleft anterior descending coronary artery occlusion (for 196 days) then vehicle control condition (for 182 days)100373left anterior descending coronary artery occlusion (for 196 days)vehicle control condition (for 182 days)
12right kidney wet weightWKYmale1.378gsham surgical control condition (for 196 days)100357sham surgical control condition (for 196 days)
15right kidney wet weightWKYmale1.3715gleft anterior descending coronary artery occlusion (for 196 days) then furosemide (10 ml/kg/d) (for 182 days)100358left anterior descending coronary artery occlusion (for 196 days)furosemide (10 ml/kg/d) (for 182 days)
15right kidney wet weightWKYmale1.3533gleft anterior descending coronary artery occlusion (for 196 days) then vehicle control condition (for 182 days)100359left anterior descending coronary artery occlusion (for 196 days)vehicle control condition (for 182 days)
5serum potassium levelWKYmale5.3mmol/lsham surgical control condition (for 224 days)100333sham surgical control condition (for 224 days)
16serum potassium levelWKYmale5mmol/lleft anterior descending coronary artery occlusion (for 224 days) then furosemide (10 mg/kg/d) (for 161 days)100334left anterior descending coronary artery occlusion (for 224 days)furosemide (10 mg/kg/d) (for 161 days)
32serum potassium levelWKYmale4.9mmol/lleft anterior descending coronary artery occlusion (for 224 days) then furosemide (10 mg/kg/d) (for 161 days) then ramipril (1 mg/kg/d) (for 182 days)100335left anterior descending coronary artery occlusion (for 224 days)furosemide (10 mg/kg/d) (for 161 days)ramipril (1 mg/kg/d) (for 182 days)
5serum sodium levelWKYmale157.7mmol/lsham surgical control condition (for 224 days)100330sham surgical control condition (for 224 days)
16serum sodium levelWKYmale153.5mmol/lleft anterior descending coronary artery occlusion (for 224 days) then furosemide (10 mg/kg/d) (for 161 days)100331left anterior descending coronary artery occlusion (for 224 days)furosemide (10 mg/kg/d) (for 161 days)
32serum sodium levelWKYmale155.1mmol/lleft anterior descending coronary artery occlusion (for 224 days) then furosemide (10 mg/kg/d) (for 161 days) then ramipril (1 mg/kg/d) (for 182 days)100332left anterior descending coronary artery occlusion (for 224 days)furosemide (10 mg/kg/d) (for 161 days)ramipril (1 mg/kg/d) (for 182 days)
5systolic blood pressureWKYmale97.8mmHgsham surgical control condition (for 224 days) then ketamine (80 mg/kg) then xylazine (10 mg/kg) 100315sham surgical control condition (for 224 days)ketamine (80 mg/kg) xylazine (10 mg/kg)
16systolic blood pressureWKYmale79.5mmHgleft anterior descending coronary artery occlusion (for 224 days) then furosemide (10 mg/kg/d) (for 161 days) then ketamine (80 mg/kg) then xylazine (10 mg/kg) 100316left anterior descending coronary artery occlusion (for 224 days)furosemide (10 mg/kg/d) (for 161 days)ketamine (80 mg/kg) xylazine (10 mg/kg)
32systolic blood pressureWKYmale75.1mmHgleft anterior descending coronary artery occlusion (for 224 days) then furosemide (10 mg/kg/d) (for 161 days) then ramipril (1 mg/kg/d) (for 182 days) then ketamine (80 mg/kg) then xylazine (10 mg/kg) 100317left anterior descending coronary artery occlusion (for 224 days)furosemide (10 mg/kg/d) (for 161 days)ramipril (1 mg/kg/d) (for 182 days)ketamine (80 mg/kg) xylazine (10 mg/kg)
5diastolic blood pressureWKYmale63.3mmHgsham surgical control condition (for 224 days) then ketamine (80 mg/kg) then xylazine (10 mg/kg) 100318sham surgical control condition (for 224 days)ketamine (80 mg/kg) xylazine (10 mg/kg)
16diastolic blood pressureWKYmale53mmHgleft anterior descending coronary artery occlusion (for 224 days) then furosemide (10 mg/kg/d) (for 161 days) then ketamine (80 mg/kg) then xylazine (10 mg/kg) 100319left anterior descending coronary artery occlusion (for 224 days)furosemide (10 mg/kg/d) (for 161 days)ketamine (80 mg/kg) xylazine (10 mg/kg)
32diastolic blood pressureWKYmale47.6mmHgleft anterior descending coronary artery occlusion (for 224 days) then furosemide (10 mg/kg/d) (for 161 days) then ramipril (1 mg/kg/d) (for 182 days) then ketamine (80 mg/kg) then xylazine (10 mg/kg) 100320left anterior descending coronary artery occlusion (for 224 days)furosemide (10 mg/kg/d) (for 161 days)ramipril (1 mg/kg/d) (for 182 days)ketamine (80 mg/kg) xylazine (10 mg/kg)
5heart rateWKYmale398beats/minsham surgical control condition (for 224 days)100312sham surgical control condition (for 224 days)
16heart rateWKYmale362beats/minleft anterior descending coronary artery occlusion (for 224 days) then furosemide (10 mg/kg/d) (for 161 days)100313left anterior descending coronary artery occlusion (for 224 days)furosemide (10 mg/kg/d) (for 161 days)
32heart rateWKYmale373beats/minleft anterior descending coronary artery occlusion (for 224 days) then furosemide (10 mg/kg/d) (for 161 days) then ramipril (1 mg/kg/d) (for 182 days)100314left anterior descending coronary artery occlusion (for 224 days)furosemide (10 mg/kg/d) (for 161 days)ramipril (1 mg/kg/d) (for 182 days)
12ejection fractionWKYmale75.8%sham surgical control condition (for 196 days)100351sham surgical control condition (for 196 days)
20ejection fractionWKYmale35.5%left anterior descending coronary artery occlusion (for 196 days) then furosemide (10 ml/kg/d) (for 182 days)100352left anterior descending coronary artery occlusion (for 196 days)furosemide (10 ml/kg/d) (for 182 days)
30ejection fractionWKYmale37%left anterior descending coronary artery occlusion (for 196 days) then vehicle control condition (for 182 days)100353left anterior descending coronary artery occlusion (for 196 days)vehicle control condition (for 182 days)
12E/A wave ratioWKYmale1.39sham surgical control condition (for 196 days)100354sham surgical control condition (for 196 days)
20E/A wave ratioWKYmale1.61left anterior descending coronary artery occlusion (for 196 days) then furosemide (10 ml/kg/d) (for 182 days)100355left anterior descending coronary artery occlusion (for 196 days)furosemide (10 ml/kg/d) (for 182 days)
30E/A wave ratioWKYmale1.85left anterior descending coronary artery occlusion (for 196 days) then vehicle control condition (for 182 days)100356left anterior descending coronary artery occlusion (for 196 days)vehicle control condition (for 182 days)
5ejection fractionWKYmale86.8%sham surgical control condition (for 224 days)100300sham surgical control condition (for 224 days)
16ejection fractionWKYmale38.5%left anterior descending coronary artery occlusion (for 224 days) then furosemide (10 mg/kg/d) (for 161 days)100301left anterior descending coronary artery occlusion (for 224 days)furosemide (10 mg/kg/d) (for 161 days)
32ejection fractionWKYmale40.5%left anterior descending coronary artery occlusion (for 224 days) then furosemide (10 mg/kg/d) (for 161 days) then ramipril (1 mg/kg/d) (for 182 days)100302left anterior descending coronary artery occlusion (for 224 days)furosemide (10 mg/kg/d) (for 161 days)ramipril (1 mg/kg/d) (for 182 days)
12lung wet weightWKYmale1.779gsham surgical control condition (for 196 days)100297sham surgical control condition (for 196 days)
20lung wet weightWKYmale2.238gleft anterior descending coronary artery occlusion (for 196 days) then furosemide (10 ml/kg/d) (for 182 days)100298left anterior descending coronary artery occlusion (for 196 days)furosemide (10 ml/kg/d) (for 182 days)
30lung wet weightWKYmale2.134gleft anterior descending coronary artery occlusion (for 196 days) then vehicle control condition (for 182 days)100299left anterior descending coronary artery occlusion (for 196 days)vehicle control condition (for 182 days)
12heart left ventricle weightWKYmale0.847gsham surgical control condition (for 196 days)100288sham surgical control condition (for 196 days)
20heart left ventricle weightWKYmale0.963gleft anterior descending coronary artery occlusion (for 196 days) then furosemide (10 ml/kg/d) (for 182 days)100289left anterior descending coronary artery occlusion (for 196 days)furosemide (10 ml/kg/d) (for 182 days)
30heart left ventricle weightWKYmale0.969gleft anterior descending coronary artery occlusion (for 196 days) then vehicle control condition (for 182 days)100290left anterior descending coronary artery occlusion (for 196 days)vehicle control condition (for 182 days)
5heart left ventricle weightWKYmale0.84gsham surgical control condition (for 224 days)100291sham surgical control condition (for 224 days)
16heart left ventricle weightWKYmale1.037gleft anterior descending coronary artery occlusion (for 224 days) then furosemide (10 mg/kg/d) (for 161 days)100292left anterior descending coronary artery occlusion (for 224 days)furosemide (10 mg/kg/d) (for 161 days)
32heart left ventricle weightWKYmale0.925gleft anterior descending coronary artery occlusion (for 224 days) then furosemide (10 mg/kg/d) (for 161 days) then ramipril (1 mg/kg/d) (for 182 days)100293left anterior descending coronary artery occlusion (for 224 days)furosemide (10 mg/kg/d) (for 161 days)ramipril (1 mg/kg/d) (for 182 days)
5heart left ventricle weight to tibia length ratioWKYmale0.194g/cmsham surgical control condition (for 224 days)100294sham surgical control condition (for 224 days)
16heart left ventricle weight to tibia length ratioWKYmale0.24g/cmleft anterior descending coronary artery occlusion (for 224 days) then furosemide (10 mg/kg/d) (for 161 days)100295left anterior descending coronary artery occlusion (for 224 days)furosemide (10 mg/kg/d) (for 161 days)
32heart left ventricle weight to tibia length ratioWKYmale0.214g/cmleft anterior descending coronary artery occlusion (for 224 days) then furosemide (10 mg/kg/d) (for 161 days) then ramipril (1 mg/kg/d) (for 182 days)100296left anterior descending coronary artery occlusion (for 224 days)furosemide (10 mg/kg/d) (for 161 days)ramipril (1 mg/kg/d) (for 182 days)
12heart weightWKYmale1.187gsham surgical control condition (for 196 days)100276sham surgical control condition (for 196 days)
20heart weightWKYmale1.563gleft anterior descending coronary artery occlusion (for 196 days) then furosemide (10 ml/kg/d) (for 182 days)100277left anterior descending coronary artery occlusion (for 196 days)furosemide (10 ml/kg/d) (for 182 days)
30heart weightWKYmale1.573gleft anterior descending coronary artery occlusion (for 196 days) then vehicle control condition (for 182 days)100278left anterior descending coronary artery occlusion (for 196 days)vehicle control condition (for 182 days)
5heart weightWKYmale1.266gsham surgical control condition (for 224 days)100279sham surgical control condition (for 224 days)
16heart weightWKYmale1.876gleft anterior descending coronary artery occlusion (for 224 days) then furosemide (10 mg/kg/d) (for 161 days)100280left anterior descending coronary artery occlusion (for 224 days)furosemide (10 mg/kg/d) (for 161 days)
32heart weightWKYmale1.437gleft anterior descending coronary artery occlusion (for 224 days) then furosemide (10 mg/kg/d) (for 161 days) then ramipril (1 mg/kg/d) (for 182 days)100281left anterior descending coronary artery occlusion (for 224 days)furosemide (10 mg/kg/d) (for 161 days)ramipril (1 mg/kg/d) (for 182 days)
5heart weight to tibia length ratioWKYmale0.278g/cmsham surgical control condition (for 224 days)100282sham surgical control condition (for 224 days)
16heart weight to tibia length ratioWKYmale0.396g/cmleft anterior descending coronary artery occlusion (for 224 days) then furosemide (10 mg/kg/d) (for 161 days)100283left anterior descending coronary artery occlusion (for 224 days)furosemide (10 mg/kg/d) (for 161 days)
32heart weight to tibia length ratioWKYmale0.314g/cmleft anterior descending coronary artery occlusion (for 224 days) then furosemide (10 mg/kg/d) (for 161 days) then ramipril (1 mg/kg/d) (for 182 days)100284left anterior descending coronary artery occlusion (for 224 days)furosemide (10 mg/kg/d) (for 161 days)ramipril (1 mg/kg/d) (for 182 days)
12body weightWKYmale223gsham surgical control condition100267sham surgical control condition
20body weightWKYmale225gleft anterior descending coronary artery occlusion then furosemide100268left anterior descending coronary artery occlusionfurosemide
30body weightWKYmale225gleft anterior descending coronary artery occlusion then vehicle control condition100269left anterior descending coronary artery occlusionvehicle control condition
12body weightWKYmale566gsham surgical control condition (for 196 days)100270sham surgical control condition (for 196 days)
20body weightWKYmale583gleft anterior descending coronary artery occlusion (for 196 days) then furosemide (10 ml/kg/d) (for 182 days)100271left anterior descending coronary artery occlusion (for 196 days)furosemide (10 ml/kg/d) (for 182 days)
30body weightWKYmale617gleft anterior descending coronary artery occlusion (for 196 days) then vehicle control condition (for 182 days)100272left anterior descending coronary artery occlusion (for 196 days)vehicle control condition (for 182 days)
5body weightWKYmale562gsham surgical control condition (for 224 days)100273sham surgical control condition (for 224 days)
16body weightWKYmale599gleft anterior descending coronary artery occlusion (for 224 days) then furosemide (10 mg/kg/d) (for 161 days)100274left anterior descending coronary artery occlusion (for 224 days)furosemide (10 mg/kg/d) (for 161 days)
32body weightWKYmale574gleft anterior descending coronary artery occlusion (for 224 days) then furosemide (10 mg/kg/d) (for 161 days) then ramipril (1 mg/kg/d) (for 182 days)100275left anterior descending coronary artery occlusion (for 224 days)furosemide (10 mg/kg/d) (for 161 days)ramipril (1 mg/kg/d) (for 182 days)
20heart left ventricle infarction size to total heart left ventricle size ratioWKYmale35.2%left anterior descending coronary artery occlusion (for 196 days) then furosemide (10 ml/kg/d) (for 182 days)100263left anterior descending coronary artery occlusion (for 196 days)furosemide (10 ml/kg/d) (for 182 days)
30heart left ventricle infarction size to total heart left ventricle size ratioWKYmale35.8%left anterior descending coronary artery occlusion (for 196 days) then vehicle control condition (for 182 days)100264left anterior descending coronary artery occlusion (for 196 days)vehicle control condition (for 182 days)
16heart left ventricle infarction size to total heart left ventricle size ratioWKYmale31.8%left anterior descending coronary artery occlusion (for 224 days) then furosemide (10 mg/kg/d) (for 161 days)100265left anterior descending coronary artery occlusion (for 224 days)furosemide (10 mg/kg/d) (for 161 days)
32heart left ventricle infarction size to total heart left ventricle size ratioWKYmale30.9%left anterior descending coronary artery occlusion (for 224 days) then furosemide (10 mg/kg/d) (for 161 days) then ramipril (1 mg/kg/d) (for 182 days)100266left anterior descending coronary artery occlusion (for 224 days)furosemide (10 mg/kg/d) (for 161 days)ramipril (1 mg/kg/d) (for 182 days)
5tibia lengthWKYmale4.3cmsham surgical control condition (for 224 days)100285sham surgical control condition (for 224 days)
16tibia lengthWKYmale4.3cmleft anterior descending coronary artery occlusion (for 224 days) then furosemide (10 mg/kg/d) (for 161 days)100286left anterior descending coronary artery occlusion (for 224 days)furosemide (10 mg/kg/d) (for 161 days)
32tibia lengthWKYmale4.3cmleft anterior descending coronary artery occlusion (for 224 days) then furosemide (10 mg/kg/d) (for 161 days) then ramipril (1 mg/kg/d) (for 182 days)100287left anterior descending coronary artery occlusion (for 224 days)furosemide (10 mg/kg/d) (for 161 days)ramipril (1 mg/kg/d) (for 182 days)
7systolic blood pressureWKYmale125.3mmHgcontrol condition108357control condition
7systolic blood pressureWKYmale123.7mmHgdiclofenac (10 mg/kg) (for 1 hours)108359diclofenac (10 mg/kg) (for 1 hours)
7systolic blood pressureWKYmale122.8mmHgcontrol condition108361control condition
7systolic blood pressureWKYmale122.6mmHgdiclofenac (20 mg/kg) (for 1 hours)108363diclofenac (20 mg/kg) (for 1 hours)
7systolic blood pressureWKYmale123.4mmHgcontrol condition108365control condition
7systolic blood pressureWKYmale122.9mmHgdiclofenac (40 mg/kg) (for 1 hours)108367diclofenac (40 mg/kg) (for 1 hours)
7measurement of minimal mechanical stimulus needed to elicit evasive reactionWKYmale11.3gx10control condition108345control condition
7measurement of minimal mechanical stimulus needed to elicit evasive reactionWKYmale11.8gx10diclofenac (10 mg/kg) (for 1 hours)108347diclofenac (10 mg/kg) (for 1 hours)
7measurement of minimal mechanical stimulus needed to elicit evasive reactionWKYmale10.9gx10control condition108349control condition
7measurement of minimal mechanical stimulus needed to elicit evasive reactionWKYmale11.4gx10diclofenac (20 mg/kg) (for 1 hours)108351diclofenac (20 mg/kg) (for 1 hours)
7measurement of minimal mechanical stimulus needed to elicit evasive reactionWKYmale11gx10control condition108353control condition
7measurement of minimal mechanical stimulus needed to elicit evasive reactionWKYmale12.8gx10diclofenac (40 mg/kg) (for 1 hours)108355diclofenac (40 mg/kg) (for 1 hours)