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PhenoMiner Database Result        View data table  |  Download data table  |  View expanded data table        


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Rat Strains

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Measurement Methods

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Age

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Experimental Conditions

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# of AnimalsPhenotypeStrainSexValueUnitsConditionsRecord IDCondition 1aCondition 1bCondition 1cCondition 2aCondition 2bCondition 2cCondition 3aCondition 3bCondition 4
6body weightSDmale180.4gnaive control condition84760naive control condition
6body weightSDmale207.4gnaive control condition84761naive control condition
6body weightSDmale225.6gnaive control condition84762naive control condition
6body weightSDmale242.6gnaive control condition84763naive control condition
6body weightSDmale257.3gnaive control condition84764naive control condition
6body weightSDmale182.3gacetaminophen (250 mg/kg) (for 1 days)84765acetaminophen (250 mg/kg) (for 1 days)
6body weightSDmale211gacetaminophen (250 mg/kg) (for 8 days)84766acetaminophen (250 mg/kg) (for 8 days)
6body weightSDmale227.7gacetaminophen (250 mg/kg) (for 15 days)84767acetaminophen (250 mg/kg) (for 15 days)
6body weightSDmale244gacetaminophen (250 mg/kg) (for 22 days)84768acetaminophen (250 mg/kg) (for 22 days)
6body weightSDmale258.5gacetaminophen (250 mg/kg) (for 28 days)84769acetaminophen (250 mg/kg) (for 28 days)
6body weightSDmale181.7gacetaminophen (500 mg/kg) (for 1 days)84770acetaminophen (500 mg/kg) (for 1 days)
6body weightSDmale209.3gacetaminophen (500 mg/kg) (for 8 days)84771acetaminophen (500 mg/kg) (for 8 days)
6body weightSDmale229.6gacetaminophen (500 mg/kg) (for 15 days)84772acetaminophen (500 mg/kg) (for 15 days)
6body weightSDmale241.1gacetaminophen (500 mg/kg) (for 22 days)84773acetaminophen (500 mg/kg) (for 22 days)
6body weightSDmale256.6gacetaminophen (500 mg/kg) (for 28 days)84774acetaminophen (500 mg/kg) (for 28 days)
6body weightSDmale182.4gacetaminophen (1000 mg/kg) (for 1 days)84775acetaminophen (1000 mg/kg) (for 1 days)
6body weightSDmale211.6gacetaminophen (1000 mg/kg) (for 8 days)84776acetaminophen (1000 mg/kg) (for 8 days)
6body weightSDmale229.6gacetaminophen (1000 mg/kg) (for 15 days)84777acetaminophen (1000 mg/kg) (for 15 days)
6body weightSDmale246.8gacetaminophen (1000 mg/kg) (for 22 days)84778acetaminophen (1000 mg/kg) (for 22 days)
6body weightSDmale262.4gacetaminophen (1000 mg/kg) (for 28 days)84779acetaminophen (1000 mg/kg) (for 28 days)
6body weightSDmale184.1gnaive control condition84781naive control condition
6body weightSDmale205.4gnaive control condition84782naive control condition
6body weightSDmale228gnaive control condition84784naive control condition
6body weightSDmale246.1gnaive control condition84786naive control condition
6body weightSDmale255.5gnaive control condition84788naive control condition
6body weightSDmale190.7gacetaminophen (1000 mg/kg) (for 1 days)84789acetaminophen (1000 mg/kg) (for 1 days)
6body weightSDmale208.8gacetaminophen (1000 mg/kg) (for 8 days)84790acetaminophen (1000 mg/kg) (for 8 days)
6body weightSDmale231.9gacetaminophen (1000 mg/kg) (for 15 days)84791acetaminophen (1000 mg/kg) (for 15 days)
6body weightSDmale252.7gacetaminophen (1000 mg/kg) (for 22 days)84792acetaminophen (1000 mg/kg) (for 22 days)
6body weightSDmale264gacetaminophen (1000 mg/kg) (for 28 days)84793acetaminophen (1000 mg/kg) (for 28 days)
6body weightSDfemale136.2gnaive control condition84794naive control condition
6body weightSDfemale148.3gnaive control condition84795naive control condition
6body weightSDfemale156.6gnaive control condition84796naive control condition
6body weightSDfemale167gnaive control condition84797naive control condition
6body weightSDfemale172.8gnaive control condition84798naive control condition
6body weightSDfemale136.3gacetaminophen (250 mg/kg) (for 1 days)84799acetaminophen (250 mg/kg) (for 1 days)
6body weightSDfemale152.8gacetaminophen (250 mg/kg) (for 8 days)84800acetaminophen (250 mg/kg) (for 8 days)
6body weightSDfemale161.2gacetaminophen (250 mg/kg) (for 15 days)84801acetaminophen (250 mg/kg) (for 15 days)
6body weightSDfemale170gacetaminophen (250 mg/kg) (for 22 days)84802acetaminophen (250 mg/kg) (for 22 days)
6body weightSDfemale175.3gacetaminophen (250 mg/kg) (for 28 days)84803acetaminophen (250 mg/kg) (for 28 days)
6body weightSDfemale134.7gacetaminophen (500 mg/kg) (for 1 days)84804acetaminophen (500 mg/kg) (for 1 days)
6body weightSDfemale147.9gacetaminophen (500 mg/kg) (for 8 days)84805acetaminophen (500 mg/kg) (for 8 days)
6body weightSDfemale151.9gacetaminophen (500 mg/kg) (for 15 days)84806acetaminophen (500 mg/kg) (for 15 days)
6body weightSDfemale157.7gacetaminophen (500 mg/kg) (for 22 days)84807acetaminophen (500 mg/kg) (for 22 days)
6body weightSDfemale162.5gacetaminophen (500 mg/kg) (for 28 days)84808acetaminophen (500 mg/kg) (for 28 days)
6body weightSDfemale134.2gacetaminophen (1000 mg/kg) (for 1 days)84809acetaminophen (1000 mg/kg) (for 1 days)
6body weightSDfemale147gacetaminophen (1000 mg/kg) (for 8 days)84810acetaminophen (1000 mg/kg) (for 8 days)
6body weightSDfemale150.9gacetaminophen (1000 mg/kg) (for 15 days)84811acetaminophen (1000 mg/kg) (for 15 days)
6body weightSDfemale157.9gacetaminophen (1000 mg/kg) (for 22 days)84812acetaminophen (1000 mg/kg) (for 22 days)
6body weightSDfemale166.7gacetaminophen (1000 mg/kg) (for 28 days)84813acetaminophen (1000 mg/kg) (for 28 days)
6body weightSDfemale137.3gnaive control condition84814naive control condition
6body weightSDfemale143.7gnaive control condition84815naive control condition
6body weightSDfemale151.6gnaive control condition84816naive control condition
6body weightSDfemale159.1gnaive control condition84817naive control condition
6body weightSDfemale160.5gnaive control condition84818naive control condition
6body weightSDfemale139gacetaminophen (1000 mg/kg) (for 1 days)84819acetaminophen (1000 mg/kg) (for 1 days)
6body weightSDfemale146.1gacetaminophen (1000 mg/kg) (for 8 days)84820acetaminophen (1000 mg/kg) (for 8 days)
6body weightSDfemale153.9gacetaminophen (1000 mg/kg) (for 15 days)84821acetaminophen (1000 mg/kg) (for 15 days)
6body weightSDfemale160.7gacetaminophen (1000 mg/kg) (for 22 days)84822acetaminophen (1000 mg/kg) (for 22 days)
6body weightSDfemale164.5gacetaminophen (1000 mg/kg) (for 28 days)84823acetaminophen (1000 mg/kg) (for 28 days)
6food intake rateSDmale33.1g/dnaive control condition84824naive control condition
6food intake rateSDmale35g/dnaive control condition84825naive control condition
6food intake rateSDmale35.8g/dnaive control condition84826naive control condition
6food intake rateSDmale31.9g/dnaive control condition84827naive control condition
6food intake rateSDmale32.5g/dacetaminophen (250 mg/kg) (for 8 days)84828acetaminophen (250 mg/kg) (for 8 days)
6food intake rateSDmale34.3g/dacetaminophen (250 mg/kg) (for 15 days)84829acetaminophen (250 mg/kg) (for 15 days)
6food intake rateSDmale34.2g/dacetaminophen (250 mg/kg) (for 22 days)84830acetaminophen (250 mg/kg) (for 22 days)
6food intake rateSDmale32.4g/dacetaminophen (250 mg/kg) (for 28 days)84831acetaminophen (250 mg/kg) (for 28 days)
6food intake rateSDmale33.3g/dacetaminophen (500 mg/kg) (for 8 days)84832acetaminophen (500 mg/kg) (for 8 days)
6food intake rateSDmale36.7g/dacetaminophen (500 mg/kg) (for 15 days)84833acetaminophen (500 mg/kg) (for 15 days)
6food intake rateSDmale39.4g/dacetaminophen (500 mg/kg) (for 22 days)84834acetaminophen (500 mg/kg) (for 22 days)
6food intake rateSDmale31.7g/dacetaminophen (500 mg/kg) (for 28 days)84835acetaminophen (500 mg/kg) (for 28 days)
6food intake rateSDmale34.9g/dacetaminophen (1000 mg/kg) (for 8 days)84836acetaminophen (1000 mg/kg) (for 8 days)
6food intake rateSDmale35.1g/dacetaminophen (1000 mg/kg) (for 15 days)84837acetaminophen (1000 mg/kg) (for 15 days)
6food intake rateSDmale34.8g/dacetaminophen (1000 mg/kg) (for 22 days)84838acetaminophen (1000 mg/kg) (for 22 days)
6food intake rateSDmale31g/dacetaminophen (1000 mg/kg) (for 28 days)84839acetaminophen (1000 mg/kg) (for 28 days)
6food intake rateSDmale33.5g/dnaive control condition84840naive control condition
6food intake rateSDmale34.5g/dnaive control condition84841naive control condition
6food intake rateSDmale33.7g/dnaive control condition84842naive control condition
6food intake rateSDmale27.9g/dnaive control condition84843naive control condition
6food intake rateSDmale39.5g/dacetaminophen (1000 mg/kg) (for 8 days)84844acetaminophen (1000 mg/kg) (for 8 days)
6food intake rateSDmale34.9g/dacetaminophen (1000 mg/kg) (for 15 days)84845acetaminophen (1000 mg/kg) (for 15 days)
6food intake rateSDmale39.4g/dacetaminophen (1000 mg/kg) (for 22 days)84846acetaminophen (1000 mg/kg) (for 22 days)
6food intake rateSDmale33.6g/dacetaminophen (1000 mg/kg) (for 28 days)84847acetaminophen (1000 mg/kg) (for 28 days)
6food intake rateSDfemale22.4g/dnaive control condition84848naive control condition
6food intake rateSDfemale21.9g/dnaive control condition84849naive control condition
6food intake rateSDfemale24.5g/dnaive control condition84850naive control condition
6food intake rateSDfemale23.1g/dnaive control condition84851naive control condition
6food intake rateSDfemale21.3g/dacetaminophen (250 mg/kg) (for 8 days)84852acetaminophen (250 mg/kg) (for 8 days)
6food intake rateSDfemale23g/dacetaminophen (250 mg/kg) (for 15 days)84853acetaminophen (250 mg/kg) (for 15 days)
6food intake rateSDfemale23.5g/dacetaminophen (250 mg/kg) (for 22 days)84854acetaminophen (250 mg/kg) (for 22 days)
6food intake rateSDfemale26g/dacetaminophen (250 mg/kg) (for 28 days)84855acetaminophen (250 mg/kg) (for 28 days)
6food intake rateSDfemale19.9g/dacetaminophen (500 mg/kg) (for 8 days)84856acetaminophen (500 mg/kg) (for 8 days)
6food intake rateSDfemale21.6g/dacetaminophen (500 mg/kg) (for 15 days)84857acetaminophen (500 mg/kg) (for 15 days)
6food intake rateSDfemale21.6g/dacetaminophen (500 mg/kg) (for 22 days)84858acetaminophen (500 mg/kg) (for 22 days)
6food intake rateSDfemale24.6g/dacetaminophen (500 mg/kg) (for 28 days)84859acetaminophen (500 mg/kg) (for 28 days)
6food intake rateSDfemale21.8g/dacetaminophen (1000 mg/kg) (for 8 days)84860acetaminophen (1000 mg/kg) (for 8 days)
6food intake rateSDfemale25.2g/dacetaminophen (1000 mg/kg) (for 15 days)84861acetaminophen (1000 mg/kg) (for 15 days)
6food intake rateSDfemale26.6g/dacetaminophen (1000 mg/kg) (for 22 days)84862acetaminophen (1000 mg/kg) (for 22 days)
6food intake rateSDfemale25.7g/dacetaminophen (1000 mg/kg) (for 28 days)84863acetaminophen (1000 mg/kg) (for 28 days)
6food intake rateSDfemale18.4g/dnaive control condition84864naive control condition
6food intake rateSDfemale21.4g/dnaive control condition84865naive control condition
6food intake rateSDfemale24.9g/dnaive control condition84866naive control condition
6food intake rateSDfemale20.4g/dnaive control condition84867naive control condition
6food intake rateSDfemale18.5g/dacetaminophen (1000 mg/kg) (for 8 days)84868acetaminophen (1000 mg/kg) (for 8 days)
6food intake rateSDfemale20g/dacetaminophen (1000 mg/kg) (for 15 days)84869acetaminophen (1000 mg/kg) (for 15 days)
6food intake rateSDfemale24.6g/dacetaminophen (1000 mg/kg) (for 22 days)84870acetaminophen (1000 mg/kg) (for 22 days)
6food intake rateSDfemale21.8g/dacetaminophen (1000 mg/kg) (for 28 days)84871acetaminophen (1000 mg/kg) (for 28 days)
6blood differential white blood cell countSDmale6.56x 1000 cells/ulnaive control condition84885naive control condition
6blood differential white blood cell countSDmale11.3x 1000 cells/ulacetaminophen (250 mg/kg) (for 28 days)84887acetaminophen (250 mg/kg) (for 28 days)
6blood differential white blood cell countSDmale7.68x 1000 cells/ulacetaminophen (500 mg/kg) (for 28 days)84888acetaminophen (500 mg/kg) (for 28 days)
6blood differential white blood cell countSDmale7.58x 1000 cells/ulacetaminophen (1000 mg/kg) (for 28 days)84890acetaminophen (1000 mg/kg) (for 28 days)
6blood differential white blood cell countSDmale8.19x 1000 cells/ulnaive control condition84891naive control condition
6blood differential white blood cell countSDmale8.34x 1000 cells/ulacetaminophen (1000 mg/kg) (for 28 days)84893acetaminophen (1000 mg/kg) (for 28 days)
6red blood cell countSDmale8.31x 10E6 cells/ulnaive control condition84894naive control condition
6red blood cell countSDmale8.56x 10E6 cells/ulacetaminophen (250 mg/kg) (for 28 days)84895acetaminophen (250 mg/kg) (for 28 days)
6red blood cell countSDmale8.47x 10E6 cells/ulacetaminophen (500 mg/kg) (for 28 days)84896acetaminophen (500 mg/kg) (for 28 days)
6red blood cell countSDmale8.64x 10E6 cells/ulacetaminophen (1000 mg/kg) (for 28 days)84897acetaminophen (1000 mg/kg) (for 28 days)
6red blood cell countSDmale8.8x 10E6 cells/ulnaive control condition84898naive control condition
6red blood cell countSDmale8.64x 10E6 cells/ulacetaminophen (1000 mg/kg) (for 28 days)84899acetaminophen (1000 mg/kg) (for 28 days)
6blood differential white blood cell countSDfemale6.1x 1000 cells/ulnaive control condition84901naive control condition
6blood differential white blood cell countSDfemale8.83x 1000 cells/ulacetaminophen (250 mg/kg) (for 28 days)84902acetaminophen (250 mg/kg) (for 28 days)
6blood differential white blood cell countSDfemale8.81x 1000 cells/ulacetaminophen (500 mg/kg) (for 28 days)84904acetaminophen (500 mg/kg) (for 28 days)
6blood differential white blood cell countSDfemale9.48x 1000 cells/ulacetaminophen (1000 mg/kg) (for 28 days)84905acetaminophen (1000 mg/kg) (for 28 days)
6blood differential white blood cell countSDfemale8.24x 1000 cells/ulnaive control condition84906naive control condition
6blood differential white blood cell countSDfemale8.68x 1000 cells/ulacetaminophen (1000 mg/kg) (for 28 days)84907acetaminophen (1000 mg/kg) (for 28 days)
6red blood cell countSDfemale8.26x 10E6 cells/ulnaive control condition84908naive control condition
6red blood cell countSDfemale8.61x 10E6 cells/ulacetaminophen (250 mg/kg) (for 28 days)84909acetaminophen (250 mg/kg) (for 28 days)
6red blood cell countSDfemale8.93x 10E6 cells/ulacetaminophen (500 mg/kg) (for 28 days)84911acetaminophen (500 mg/kg) (for 28 days)
6red blood cell countSDfemale8.97x 10E6 cells/ulacetaminophen (1000 mg/kg) (for 28 days)84912acetaminophen (1000 mg/kg) (for 28 days)
6red blood cell countSDfemale8.77x 10E6 cells/ulnaive control condition84913naive control condition
6red blood cell countSDfemale8.97x 10E6 cells/ulacetaminophen (1000 mg/kg) (for 28 days)84914acetaminophen (1000 mg/kg) (for 28 days)
6blood hemoglobin levelSDmale13.8g/dlnaive control condition84939naive control condition
6blood hemoglobin levelSDmale14.02g/dlacetaminophen (250 mg/kg) (for 28 days)84940acetaminophen (250 mg/kg) (for 28 days)
6blood hemoglobin levelSDmale13.68g/dlacetaminophen (500 mg/kg) (for 28 days)84941acetaminophen (500 mg/kg) (for 28 days)
6blood hemoglobin levelSDmale13.98g/dlacetaminophen (1000 mg/kg) (for 28 days)84942acetaminophen (1000 mg/kg) (for 28 days)
6blood hemoglobin levelSDmale13.9g/dlnaive control condition84943naive control condition
6blood hemoglobin levelSDmale13.75g/dlacetaminophen (1000 mg/kg) (for 28 days)84944acetaminophen (1000 mg/kg) (for 28 days)
6blood hemoglobin levelSDfemale11.28g/dlnaive control condition84945naive control condition
6blood hemoglobin levelSDfemale11.57g/dlacetaminophen (250 mg/kg) (for 28 days)84946acetaminophen (250 mg/kg) (for 28 days)
6blood hemoglobin levelSDfemale11.9g/dlacetaminophen (500 mg/kg) (for 28 days)84947acetaminophen (500 mg/kg) (for 28 days)
6blood hemoglobin levelSDfemale12.98g/dlacetaminophen (1000 mg/kg) (for 28 days)84948acetaminophen (1000 mg/kg) (for 28 days)
6blood hemoglobin levelSDfemale11.02g/dlnaive control condition84949naive control condition
6blood hemoglobin levelSDfemale12.38g/dlacetaminophen (1000 mg/kg) (for 28 days)84950acetaminophen (1000 mg/kg) (for 28 days)
6hematocritSDmale45.25%naive control condition84951naive control condition
6hematocritSDmale44.38%acetaminophen (250 mg/kg) (for 28 days)84952acetaminophen (250 mg/kg) (for 28 days)
6hematocritSDmale44.05%acetaminophen (500 mg/kg) (for 28 days)84953acetaminophen (500 mg/kg) (for 28 days)
6hematocritSDmale45.1%acetaminophen (1000 mg/kg) (for 28 days)84954acetaminophen (1000 mg/kg) (for 28 days)
6hematocritSDmale45.68%naive control condition84955naive control condition
6hematocritSDmale45.18%acetaminophen (1000 mg/kg) (for 28 days)84956acetaminophen (1000 mg/kg) (for 28 days)
6hematocritSDfemale41.03%naive control condition84957naive control condition
6hematocritSDfemale40.22%acetaminophen (250 mg/kg) (for 28 days)84958acetaminophen (250 mg/kg) (for 28 days)
6hematocritSDfemale40.85%acetaminophen (500 mg/kg) (for 28 days)84959acetaminophen (500 mg/kg) (for 28 days)
6hematocritSDfemale41.85%acetaminophen (1000 mg/kg) (for 28 days)84960acetaminophen (1000 mg/kg) (for 28 days)
6hematocritSDfemale39.8%naive control condition84961naive control condition
6hematocritSDfemale41.5%acetaminophen (1000 mg/kg) (for 28 days)84962acetaminophen (1000 mg/kg) (for 28 days)
6red blood cell distribution width-coefficient of variationSDmale11.57%naive control condition84963naive control condition
6red blood cell distribution width-coefficient of variationSDmale12.35%acetaminophen (250 mg/kg) (for 28 days)84964acetaminophen (250 mg/kg) (for 28 days)
6red blood cell distribution width-coefficient of variationSDmale11.97%acetaminophen (500 mg/kg) (for 28 days)84965acetaminophen (500 mg/kg) (for 28 days)
6red blood cell distribution width-coefficient of variationSDmale11.87%acetaminophen (1000 mg/kg) (for 28 days)84966acetaminophen (1000 mg/kg) (for 28 days)
6red blood cell distribution width-coefficient of variationSDmale11.9%naive control condition84967naive control condition
6red blood cell distribution width-coefficient of variationSDmale11.73%acetaminophen (1000 mg/kg) (for 28 days)84968acetaminophen (1000 mg/kg) (for 28 days)
6red blood cell distribution width-coefficient of variationSDfemale10.98%naive control condition84969naive control condition
6red blood cell distribution width-coefficient of variationSDfemale11.38%acetaminophen (250 mg/kg) (for 28 days)84970acetaminophen (250 mg/kg) (for 28 days)
6red blood cell distribution width-coefficient of variationSDfemale12.62%acetaminophen (500 mg/kg) (for 28 days)84971acetaminophen (500 mg/kg) (for 28 days)
6red blood cell distribution width-coefficient of variationSDfemale11.13%acetaminophen (1000 mg/kg) (for 28 days)84972acetaminophen (1000 mg/kg) (for 28 days)
6red blood cell distribution width-coefficient of variationSDfemale11.32%naive control condition84973naive control condition
6red blood cell distribution width-coefficient of variationSDmale11.35%acetaminophen (1000 mg/kg) (for 28 days)84974acetaminophen (1000 mg/kg) (for 28 days)
6platelet countSDmale1095.83x 1000 cells/ulnaive control condition84975naive control condition
6platelet countSDmale1148.83x 1000 cells/ulacetaminophen (250 mg/kg) (for 28 days)84976acetaminophen (250 mg/kg) (for 28 days)
6platelet countSDmale1177.5x 1000 cells/ulacetaminophen (500 mg/kg) (for 28 days)84977acetaminophen (500 mg/kg) (for 28 days)
6platelet countSDmale1263x 1000 cells/ulacetaminophen (1000 mg/kg) (for 28 days)84978acetaminophen (1000 mg/kg) (for 28 days)
6platelet countSDmale1171x 1000 cells/ulnaive control condition84979naive control condition
6platelet countSDmale1122.17x 1000 cells/ulacetaminophen (1000 mg/kg) (for 28 days)84980acetaminophen (1000 mg/kg) (for 28 days)
6platelet countSDfemale816x 1000 cells/ulnaive control condition84981naive control condition
6platelet countSDfemale855.83x 1000 cells/ulacetaminophen (250 mg/kg) (for 28 days)84982acetaminophen (250 mg/kg) (for 28 days)
6platelet countSDfemale919x 1000 cells/ulacetaminophen (500 mg/kg) (for 28 days)84983acetaminophen (500 mg/kg) (for 28 days)
6platelet countSDfemale1025.83x 1000 cells/ulacetaminophen (1000 mg/kg) (for 28 days)84984acetaminophen (1000 mg/kg) (for 28 days)
6platelet countSDfemale846x 1000 cells/ulnaive control condition84985naive control condition
6platelet countSDfemale931x 1000 cells/ulacetaminophen (1000 mg/kg) (for 28 days)84986acetaminophen (1000 mg/kg) (for 28 days)
6blood glucose levelSDmale115.3mg/dlnaive control condition84987naive control condition
6blood glucose levelSDmale103.7mg/dlacetaminophen (250 mg/kg) (for 28 days)84988acetaminophen (250 mg/kg) (for 28 days)
6blood glucose levelSDmale127mg/dlacetaminophen (500 mg/kg) (for 28 days)84989acetaminophen (500 mg/kg) (for 28 days)
6blood glucose levelSDmale86.8mg/dlacetaminophen (1000 mg/kg) (for 28 days)84990acetaminophen (1000 mg/kg) (for 28 days)
6blood glucose levelSDmale72.48mg/dlnaive control condition84991naive control condition
6blood glucose levelSDmale62.11mg/dlacetaminophen (1000 mg/kg) (for 28 days)84992acetaminophen (1000 mg/kg) (for 28 days)
6blood glucose levelSDfemale70.7mg/dlnaive control condition84993naive control condition
6blood glucose levelSDfemale109.2mg/dlacetaminophen (250 mg/kg) (for 28 days)84994acetaminophen (250 mg/kg) (for 28 days)
6blood glucose levelSDfemale116.2mg/dlacetaminophen (500 mg/kg) (for 28 days)84995acetaminophen (500 mg/kg) (for 28 days)
6blood glucose levelSDfemale181.5mg/dlacetaminophen (1000 mg/kg) (for 28 days)84996acetaminophen (1000 mg/kg) (for 28 days)
6blood glucose levelSDfemale82.67mg/dlnaive control condition84997naive control condition
6blood glucose levelSDfemale90.83mg/dlacetaminophen (1000 mg/kg) (for 28 days)84998acetaminophen (1000 mg/kg) (for 28 days)
6blood albumin levelSDmale3.3g/dlnaive control condition84999naive control condition
6blood albumin levelSDmale3.3g/dlacetaminophen (250 mg/kg) (for 28 days)85000acetaminophen (250 mg/kg) (for 28 days)
6blood albumin levelSDmale3.2g/dlacetaminophen (500 mg/kg) (for 28 days)85001acetaminophen (500 mg/kg) (for 28 days)
6blood albumin levelSDmale3.5g/dlacetaminophen (1000 mg/kg) (for 28 days)85002acetaminophen (1000 mg/kg) (for 28 days)
6blood albumin levelSDmale2.93g/dlnaive control condition85003naive control condition
6blood albumin levelSDmale2.48g/dlacetaminophen (1000 mg/kg) (for 28 days)85004acetaminophen (1000 mg/kg) (for 28 days)
6blood albumin levelSDfemale3.5g/dlnaive control condition85005naive control condition
6blood albumin levelSDfemale3.5g/dlacetaminophen (250 mg/kg) (for 28 days)85006acetaminophen (250 mg/kg) (for 28 days)
6blood albumin levelSDfemale3.3g/dlacetaminophen (500 mg/kg) (for 28 days)85007acetaminophen (500 mg/kg) (for 28 days)
6blood albumin levelSDfemale4.6g/dlacetaminophen (1000 mg/kg) (for 28 days)85008acetaminophen (1000 mg/kg) (for 28 days)
6blood albumin levelSDfemale3.6g/dlnaive control condition85009naive control condition
6blood albumin levelSDfemale3.62g/dlacetaminophen (1000 mg/kg) (for 28 days)85010acetaminophen (1000 mg/kg) (for 28 days)
6plasma total protein levelSDmale63mg/mlnaive control condition85011naive control condition
6plasma total protein levelSDmale63mg/mlacetaminophen (250 mg/kg) (for 28 days)85012acetaminophen (250 mg/kg) (for 28 days)
6plasma total protein levelSDmale62mg/mlacetaminophen (500 mg/kg) (for 28 days)85013acetaminophen (500 mg/kg) (for 28 days)
6plasma total protein levelSDmale65mg/mlacetaminophen (1000 mg/kg) (for 28 days)85014acetaminophen (1000 mg/kg) (for 28 days)
6plasma total protein levelSDmale54.3mg/mlnaive control condition85015naive control condition
6plasma total protein levelSDmale46mg/mlacetaminophen (1000 mg/kg) (for 28 days)85016acetaminophen (1000 mg/kg) (for 28 days)
6plasma total protein levelSDfemale65mg/mlnaive control condition85017naive control condition
6plasma total protein levelSDfemale64mg/mlacetaminophen (250 mg/kg) (for 28 days)85018acetaminophen (250 mg/kg) (for 28 days)
6plasma total protein levelSDfemale62mg/mlacetaminophen (500 mg/kg) (for 28 days)85019acetaminophen (500 mg/kg) (for 28 days)
6plasma total protein levelSDfemale83mg/mlacetaminophen (1000 mg/kg) (for 28 days)85020acetaminophen (1000 mg/kg) (for 28 days)
6plasma total protein levelSDfemale66mg/mlnaive control condition85021naive control condition
6plasma total protein levelSDfemale67mg/mlacetaminophen (1000 mg/kg) (for 28 days)85022acetaminophen (1000 mg/kg) (for 28 days)
6blood globulin levelSDmale2.9g/dlnaive control condition85023naive control condition
6blood globulin levelSDmale3g/dlacetaminophen (250 mg/kg) (for 28 days)85024acetaminophen (250 mg/kg) (for 28 days)
6blood globulin levelSDmale2.9g/dlacetaminophen (500 mg/kg) (for 28 days)85025acetaminophen (500 mg/kg) (for 28 days)
6blood globulin levelSDmale3g/dlacetaminophen (1000 mg/kg) (for 28 days)85026acetaminophen (1000 mg/kg) (for 28 days)
6blood globulin levelSDmale2.5g/dlnaive control condition85027naive control condition
6blood globulin levelSDmale2.12g/dlacetaminophen (1000 mg/kg) (for 28 days)85028acetaminophen (1000 mg/kg) (for 28 days)
6blood globulin levelSDfemale3g/dlnaive control condition85029naive control condition
6blood globulin levelSDfemale3g/dlacetaminophen (250 mg/kg) (for 28 days)85030acetaminophen (250 mg/kg) (for 28 days)
6blood globulin levelSDfemale2.9g/dlacetaminophen (500 mg/kg) (for 28 days)85031acetaminophen (500 mg/kg) (for 28 days)
6blood globulin levelSDfemale3.8g/dlacetaminophen (1000 mg/kg) (for 28 days)85032acetaminophen (1000 mg/kg) (for 28 days)
6blood globulin levelSDfemale3g/dlnaive control condition85033naive control condition
6blood globulin levelSDfemale3.08g/dlacetaminophen (1000 mg/kg) (for 28 days)85034acetaminophen (1000 mg/kg) (for 28 days)
6blood urea nitrogen levelSDmale16mg/dlnaive control condition85035naive control condition
6blood urea nitrogen levelSDmale14.5mg/dlacetaminophen (250 mg/kg) (for 28 days)85036acetaminophen (250 mg/kg) (for 28 days)
6blood urea nitrogen levelSDmale14.2mg/dlacetaminophen (500 mg/kg) (for 28 days)85037acetaminophen (500 mg/kg) (for 28 days)
6blood urea nitrogen levelSDmale15.5mg/dlacetaminophen (1000 mg/kg) (for 28 days)85038acetaminophen (1000 mg/kg) (for 28 days)
6blood urea nitrogen levelSDmale13.56mg/dlnaive control condition85039naive control condition
6blood urea nitrogen levelSDmale10.97mg/dlacetaminophen (1000 mg/kg) (for 28 days)85040acetaminophen (1000 mg/kg) (for 28 days)
6blood urea nitrogen levelSDfemale18.7mg/dlnaive control condition85041naive control condition
6blood urea nitrogen levelSDfemale13.3mg/dlacetaminophen (250 mg/kg) (for 28 days)85042acetaminophen (250 mg/kg) (for 28 days)
6blood urea nitrogen levelSDfemale15.5mg/dlacetaminophen (500 mg/kg) (for 28 days)85043acetaminophen (500 mg/kg) (for 28 days)
6blood urea nitrogen levelSDfemale38.2mg/dlacetaminophen (1000 mg/kg) (for 28 days)85044acetaminophen (1000 mg/kg) (for 28 days)
6blood urea nitrogen levelSDfemale16mg/dlnaive control condition85045naive control condition
6blood urea nitrogen levelSDfemale21mg/dlacetaminophen (1000 mg/kg) (for 28 days)85046acetaminophen (1000 mg/kg) (for 28 days)
6blood albumin level to blood globulin level ratioSDmale0.8naive control condition85047naive control condition
6blood albumin level to blood globulin level ratioSDmale0.9acetaminophen (250 mg/kg) (for 28 days)85048acetaminophen (250 mg/kg) (for 28 days)
6blood albumin level to blood globulin level ratioSDmale0.9acetaminophen (500 mg/kg) (for 28 days)85049acetaminophen (500 mg/kg) (for 28 days)
6blood albumin level to blood globulin level ratioSDmale0.9acetaminophen (1000 mg/kg) (for 28 days)85050acetaminophen (1000 mg/kg) (for 28 days)
6blood albumin level to blood globulin level ratioSDmale0.77naive control condition85051naive control condition
6blood albumin level to blood globulin level ratioSDmale0.66acetaminophen (1000 mg/kg) (for 28 days)85052acetaminophen (1000 mg/kg) (for 28 days)
6blood albumin level to blood globulin level ratioSDfemale0.9naive control condition85053naive control condition
6blood albumin level to blood globulin level ratioSDfemale1.1acetaminophen (250 mg/kg) (for 28 days)85054acetaminophen (250 mg/kg) (for 28 days)
6blood albumin level to blood globulin level ratioSDfemale1.1acetaminophen (500 mg/kg) (for 28 days)85055acetaminophen (500 mg/kg) (for 28 days)
6blood albumin level to blood globulin level ratioSDfemale1acetaminophen (1000 mg/kg) (for 28 days)85056acetaminophen (1000 mg/kg) (for 28 days)
6blood albumin level to blood globulin level ratioSDfemale0.93naive control condition85057naive control condition
6blood albumin level to blood globulin level ratioSDfemale0.97acetaminophen (1000 mg/kg) (for 28 days)85058acetaminophen (1000 mg/kg) (for 28 days)
6blood creatinine levelSDmale0.5mg/dlnaive control condition85059naive control condition
6blood creatinine levelSDmale0.4mg/dlacetaminophen (250 mg/kg) (for 28 days)85060acetaminophen (250 mg/kg) (for 28 days)
6blood creatinine levelSDmale0.4mg/dlacetaminophen (500 mg/kg) (for 28 days)85061acetaminophen (500 mg/kg) (for 28 days)
6blood creatinine levelSDmale0.4mg/dlacetaminophen (1000 mg/kg) (for 28 days)85062acetaminophen (1000 mg/kg) (for 28 days)
6blood creatinine levelSDmale0.37mg/dlnaive control condition85063naive control condition
6blood creatinine levelSDmale0.3mg/dlacetaminophen (1000 mg/kg) (for 28 days)85064acetaminophen (1000 mg/kg) (for 28 days)
6blood creatinine levelSDfemale0.4mg/dlnaive control condition85065naive control condition
6blood creatinine levelSDfemale0.4mg/dlacetaminophen (250 mg/kg) (for 28 days)85066acetaminophen (250 mg/kg) (for 28 days)
6blood creatinine levelSDfemale0.3mg/dlacetaminophen (500 mg/kg) (for 28 days)85067acetaminophen (500 mg/kg) (for 28 days)
6blood creatinine levelSDfemale1.1mg/dlacetaminophen (1000 mg/kg) (for 28 days)85068acetaminophen (1000 mg/kg) (for 28 days)
6blood creatinine levelSDfemale0.33mg/dlnaive control condition85069naive control condition
6blood creatinine levelSDfemale0.33mg/dlacetaminophen (1000 mg/kg) (for 28 days)85070acetaminophen (1000 mg/kg) (for 28 days)
6blood aspartate aminotransferase activity levelSDmale169.7U/lnaive control condition85071naive control condition
6blood aspartate aminotransferase activity levelSDmale136.8U/lacetaminophen (250 mg/kg) (for 28 days)85072acetaminophen (250 mg/kg) (for 28 days)
6blood aspartate aminotransferase activity levelSDmale140.8U/lacetaminophen (500 mg/kg) (for 28 days)85073acetaminophen (500 mg/kg) (for 28 days)
6blood aspartate aminotransferase activity levelSDmale178.5U/lacetaminophen (1000 mg/kg) (for 28 days)85074acetaminophen (1000 mg/kg) (for 28 days)
6blood aspartate aminotransferase activity levelSDmale145.57U/lnaive control condition85075naive control condition
6blood aspartate aminotransferase activity levelSDmale125.07U/lacetaminophen (1000 mg/kg) (for 28 days)85076acetaminophen (1000 mg/kg) (for 28 days)
6blood aspartate aminotransferase activity levelSDfemale162.23U/lnaive control condition85077naive control condition
6blood aspartate aminotransferase activity levelSDfemale118.67U/lacetaminophen (250 mg/kg) (for 28 days)85078acetaminophen (250 mg/kg) (for 28 days)
6blood aspartate aminotransferase activity levelSDfemale116.83U/lacetaminophen (500 mg/kg) (for 28 days)85079acetaminophen (500 mg/kg) (for 28 days)
6blood aspartate aminotransferase activity levelSDfemale263.17U/lacetaminophen (1000 mg/kg) (for 28 days)85080acetaminophen (1000 mg/kg) (for 28 days)
6blood aspartate aminotransferase activity levelSDfemale155.67U/lnaive control condition85081naive control condition
6blood aspartate aminotransferase activity levelSDfemale146.5U/lacetaminophen (1000 mg/kg) (for 28 days)85082acetaminophen (1000 mg/kg) (for 28 days)
6blood alanine aminotransferase activity levelSDmale46.7U/lnaive control condition85083naive control condition
6blood alanine aminotransferase activity levelSDmale59.2U/lacetaminophen (250 mg/kg) (for 28 days)85084acetaminophen (250 mg/kg) (for 28 days)
6blood alanine aminotransferase activity levelSDmale59.8U/lacetaminophen (500 mg/kg) (for 28 days)85085acetaminophen (500 mg/kg) (for 28 days)
6blood alanine aminotransferase activity levelSDmale54U/lacetaminophen (1000 mg/kg) (for 28 days)85086acetaminophen (1000 mg/kg) (for 28 days)
6blood alanine aminotransferase activity levelSDmale46.73U/lnaive control condition85087naive control condition
6blood alanine aminotransferase activity levelSDmale39.74U/lacetaminophen (1000 mg/kg) (for 28 days)85088acetaminophen (1000 mg/kg) (for 28 days)
6blood alanine aminotransferase activity levelSDfemale46.83U/lnaive control condition85089naive control condition
6blood alanine aminotransferase activity levelSDfemale57.33U/lacetaminophen (250 mg/kg) (for 28 days)85090acetaminophen (250 mg/kg) (for 28 days)
6blood alanine aminotransferase activity levelSDfemale59.67U/lacetaminophen (500 mg/kg) (for 28 days)85091acetaminophen (500 mg/kg) (for 28 days)
6blood alanine aminotransferase activity levelSDfemale42.5U/lnaive control condition85092naive control condition
6blood alanine aminotransferase activity levelSDfemale49.67U/lacetaminophen (1000 mg/kg) (for 28 days)85093acetaminophen (1000 mg/kg) (for 28 days)
6blood alanine aminotransferase activity levelSDfemale116.5U/lacetaminophen (1000 mg/kg) (for 28 days)85094acetaminophen (1000 mg/kg) (for 28 days)
6blood alkaline phosphatase activity levelSDmale298.5U/lnaive control condition85095naive control condition
6blood alkaline phosphatase activity levelSDmale469U/lacetaminophen (250 mg/kg) (for 28 days)85096acetaminophen (250 mg/kg) (for 28 days)
6blood alkaline phosphatase activity levelSDmale327.2U/lacetaminophen (500 mg/kg) (for 28 days)85097acetaminophen (500 mg/kg) (for 28 days)
6blood alkaline phosphatase activity levelSDmale295.8U/lacetaminophen (1000 mg/kg) (for 28 days)85098acetaminophen (1000 mg/kg) (for 28 days)
6blood alkaline phosphatase activity levelSDmale268.14U/lnaive control condition85099naive control condition
6blood alkaline phosphatase activity levelSDmale245.33U/lacetaminophen (1000 mg/kg) (for 28 days)85100acetaminophen (1000 mg/kg) (for 28 days)
6blood alkaline phosphatase activity levelSDfemale206U/lnaive control condition85101naive control condition
6blood alkaline phosphatase activity levelSDfemale353.33U/lacetaminophen (250 mg/kg) (for 28 days)85102acetaminophen (250 mg/kg) (for 28 days)
6blood alkaline phosphatase activity levelSDfemale416.5U/lacetaminophen (500 mg/kg) (for 28 days)85103acetaminophen (500 mg/kg) (for 28 days)
6blood alkaline phosphatase activity levelSDfemale423.17U/lacetaminophen (1000 mg/kg) (for 28 days)85104acetaminophen (1000 mg/kg) (for 28 days)
6blood alkaline phosphatase activity levelSDfemale178.67U/lnaive control condition85105naive control condition
6blood alkaline phosphatase activity levelSDfemale228.17U/lacetaminophen (1000 mg/kg) (for 28 days)85106acetaminophen (1000 mg/kg) (for 28 days)
6blood bilirubin levelSDmale0.3mg/dlnaive control condition85107naive control condition
6blood bilirubin levelSDmale0.41mg/dlacetaminophen (250 mg/kg) (for 28 days)85108acetaminophen (250 mg/kg) (for 28 days)
6blood bilirubin levelSDmale0.41mg/dlacetaminophen (500 mg/kg) (for 28 days)85109acetaminophen (500 mg/kg) (for 28 days)
6blood bilirubin levelSDmale0.47mg/dlacetaminophen (1000 mg/kg) (for 28 days)85110acetaminophen (1000 mg/kg) (for 28 days)
6blood bilirubin levelSDmale0.52mg/dlnaive control condition85111naive control condition
6blood bilirubin levelSDmale0.55mg/dlacetaminophen (1000 mg/kg) (for 28 days)85112acetaminophen (1000 mg/kg) (for 28 days)
6blood bilirubin levelSDfemale0.44mg/dlnaive control condition85113naive control condition
6blood bilirubin levelSDfemale0.34mg/dlacetaminophen (250 mg/kg) (for 28 days)85114acetaminophen (250 mg/kg) (for 28 days)
6blood bilirubin levelSDfemale0.39mg/dlacetaminophen (500 mg/kg) (for 28 days)85115acetaminophen (500 mg/kg) (for 28 days)
6blood bilirubin levelSDfemale1.33mg/dlacetaminophen (1000 mg/kg) (for 28 days)85116acetaminophen (1000 mg/kg) (for 28 days)
6blood bilirubin levelSDfemale0.6mg/dlnaive control condition85117naive control condition
6blood bilirubin levelSDfemale0.63mg/dlacetaminophen (1000 mg/kg) (for 28 days)85118acetaminophen (1000 mg/kg) (for 28 days)
6blood sodium levelSDmale143.8mmol/lnaive control condition85119naive control condition
6blood sodium levelSDmale144.7mmol/lacetaminophen (250 mg/kg) (for 28 days)85120acetaminophen (250 mg/kg) (for 28 days)
6blood sodium levelSDmale145.2mmol/lacetaminophen (500 mg/kg) (for 28 days)85121acetaminophen (500 mg/kg) (for 28 days)
6blood sodium levelSDmale147.8mmol/lacetaminophen (1000 mg/kg) (for 28 days)85122acetaminophen (1000 mg/kg) (for 28 days)
6blood sodium levelSDmale123.26mmol/lnaive control condition85123naive control condition
6blood sodium levelSDmale104.23mmol/lacetaminophen (1000 mg/kg) (for 28 days)85124acetaminophen (1000 mg/kg) (for 28 days)
6blood sodium levelSDfemale146.5mmol/lnaive control condition85125naive control condition
6blood sodium levelSDfemale146.67mmol/lacetaminophen (250 mg/kg) (for 28 days)85126acetaminophen (250 mg/kg) (for 28 days)
6blood sodium levelSDfemale146.67mmol/lacetaminophen (500 mg/kg) (for 28 days)85127acetaminophen (500 mg/kg) (for 28 days)
6blood sodium levelSDfemale150.33mmol/lacetaminophen (1000 mg/kg) (for 28 days)85128acetaminophen (1000 mg/kg) (for 28 days)
6blood sodium levelSDfemale144.33mmol/lnaive control condition85129naive control condition
6blood sodium levelSDfemale145.33mmol/lacetaminophen (1000 mg/kg) (for 28 days)85130acetaminophen (1000 mg/kg) (for 28 days)
6blood potassium levelSDmale5mmol/lnaive control condition85131naive control condition
6blood potassium levelSDmale5mmol/lacetaminophen (250 mg/kg) (for 28 days)85132acetaminophen (250 mg/kg) (for 28 days)
6blood potassium levelSDmale5mmol/lacetaminophen (500 mg/kg) (for 28 days)85133acetaminophen (500 mg/kg) (for 28 days)
6blood potassium levelSDmale5.4mmol/lacetaminophen (1000 mg/kg) (for 28 days)85134acetaminophen (1000 mg/kg) (for 28 days)
6blood potassium levelSDmale4.6mmol/lnaive control condition85135naive control condition
6blood potassium levelSDmale3.88mmol/lacetaminophen (1000 mg/kg) (for 28 days)85136acetaminophen (1000 mg/kg) (for 28 days)
6blood potassium levelSDfemale4.57mmol/lnaive control condition85137naive control condition
6blood potassium levelSDfemale4.6mmol/lacetaminophen (250 mg/kg) (for 28 days)85138acetaminophen (250 mg/kg) (for 28 days)
6blood potassium levelSDfemale4.75mmol/lacetaminophen (500 mg/kg) (for 28 days)85139acetaminophen (500 mg/kg) (for 28 days)
6blood potassium levelSDfemale2.27mmol/lacetaminophen (1000 mg/kg) (for 28 days)85140acetaminophen (1000 mg/kg) (for 28 days)
6blood potassium levelSDfemale4.7mmol/lnaive control condition85141naive control condition
6blood potassium levelSDfemale4.77mmol/lacetaminophen (1000 mg/kg) (for 28 days)85142acetaminophen (1000 mg/kg) (for 28 days)
6blood calcium levelSDmale10mg/dlnaive control condition85143naive control condition
6blood calcium levelSDmale10mg/dlacetaminophen (250 mg/kg) (for 28 days)85144acetaminophen (250 mg/kg) (for 28 days)
6blood calcium levelSDmale10.2mg/dlacetaminophen (500 mg/kg) (for 28 days)85145acetaminophen (500 mg/kg) (for 28 days)
6blood calcium levelSDmale9.9mg/dlacetaminophen (1000 mg/kg) (for 28 days)85146acetaminophen (1000 mg/kg) (for 28 days)
6blood calcium levelSDmale8.27mg/dlnaive control condition85147naive control condition
6blood calcium levelSDmale7.03mg/dlacetaminophen (1000 mg/kg) (for 28 days)85148acetaminophen (1000 mg/kg) (for 28 days)
6blood calcium levelSDfemale9.95mg/dlnaive control condition85149naive control condition
6blood calcium levelSDfemale10.05mg/dlacetaminophen (250 mg/kg) (for 28 days)85150acetaminophen (250 mg/kg) (for 28 days)
6blood calcium levelSDfemale10mg/dlacetaminophen (500 mg/kg) (for 28 days)85151acetaminophen (500 mg/kg) (for 28 days)
6blood calcium levelSDfemale10.42mg/dlacetaminophen (1000 mg/kg) (for 28 days)85152acetaminophen (1000 mg/kg) (for 28 days)
6blood calcium levelSDfemale10.23mg/dlnaive control condition85153naive control condition
6blood calcium levelSDfemale10.08mg/dlacetaminophen (1000 mg/kg) (for 28 days)85154acetaminophen (1000 mg/kg) (for 28 days)
6blood phosphate levelSDmale6.3mg/dlnaive control condition85155naive control condition
6blood phosphate levelSDmale6mg/dlacetaminophen (250 mg/kg) (for 28 days)85156acetaminophen (250 mg/kg) (for 28 days)
6blood phosphate levelSDmale6.1mg/dlacetaminophen (500 mg/kg) (for 28 days)85157acetaminophen (500 mg/kg) (for 28 days)
6blood phosphate levelSDmale5.9mg/dlacetaminophen (1000 mg/kg) (for 28 days)85158acetaminophen (1000 mg/kg) (for 28 days)
6blood phosphate levelSDmale4.87mg/dlnaive control condition85159naive control condition
6blood phosphate levelSDmale4.06mg/dlacetaminophen (1000 mg/kg) (for 28 days)85160acetaminophen (1000 mg/kg) (for 28 days)
6blood phosphate levelSDfemale5.6mg/dlnaive control condition85161naive control condition
6blood phosphate levelSDfemale5.88mg/dlacetaminophen (250 mg/kg) (for 28 days)85162acetaminophen (250 mg/kg) (for 28 days)
6blood phosphate levelSDfemale5.98mg/dlacetaminophen (500 mg/kg) (for 28 days)85163acetaminophen (500 mg/kg) (for 28 days)
6blood phosphate levelSDfemale6.53mg/dlacetaminophen (1000 mg/kg) (for 28 days)85164acetaminophen (1000 mg/kg) (for 28 days)
6blood phosphate levelSDfemale5.45mg/dlnaive control condition85165naive control condition
6blood phosphate levelSDfemale5.5mg/dlacetaminophen (1000 mg/kg) (for 28 days)85166acetaminophen (1000 mg/kg) (for 28 days)
6blood total cholesterol levelSDmale78mg/dlnaive control condition85167naive control condition
6blood total cholesterol levelSDmale92.8mg/dlacetaminophen (250 mg/kg) (for 28 days)85168acetaminophen (250 mg/kg) (for 28 days)
6blood total cholesterol levelSDmale87.8mg/dlacetaminophen (500 mg/kg) (for 28 days)85169acetaminophen (500 mg/kg) (for 28 days)
6blood total cholesterol levelSDmale86.8mg/dlacetaminophen (1000 mg/kg) (for 28 days)85170acetaminophen (1000 mg/kg) (for 28 days)
6blood total cholesterol levelSDmale73.99mg/dlnaive control condition85171naive control condition
6blood total cholesterol levelSDmale60.1mg/dlacetaminophen (1000 mg/kg) (for 28 days)85172acetaminophen (1000 mg/kg) (for 28 days)
6blood total cholesterol levelSDfemale102.5mg/dlnaive control condition85173naive control condition
6blood total cholesterol levelSDfemale92.2mg/dlacetaminophen (250 mg/kg) (for 28 days)85174acetaminophen (250 mg/kg) (for 28 days)
6blood total cholesterol levelSDfemale102.3mg/dlacetaminophen (500 mg/kg) (for 28 days)85175acetaminophen (500 mg/kg) (for 28 days)
6blood total cholesterol levelSDfemale96.5mg/dlacetaminophen (1000 mg/kg) (for 28 days)85176acetaminophen (1000 mg/kg) (for 28 days)
6blood total cholesterol levelSDfemale112.17mg/dlnaive control condition85177naive control condition
6blood total cholesterol levelSDfemale109.17mg/dlacetaminophen (1000 mg/kg) (for 28 days)85178acetaminophen (1000 mg/kg) (for 28 days)
6blood triglyceride levelSDmale52.3mg/dlnaive control condition85179naive control condition
6blood triglyceride levelSDmale141.2mg/dlacetaminophen (250 mg/kg) (for 28 days)85180acetaminophen (250 mg/kg) (for 28 days)
6blood triglyceride levelSDmale109.5mg/dlacetaminophen (500 mg/kg) (for 28 days)85181acetaminophen (500 mg/kg) (for 28 days)
6blood triglyceride levelSDmale92.3mg/dlacetaminophen (1000 mg/kg) (for 28 days)85182acetaminophen (1000 mg/kg) (for 28 days)
6blood triglyceride levelSDmale65.45mg/dlnaive control condition85183naive control condition
6blood triglyceride levelSDmale58.81mg/dlacetaminophen (1000 mg/kg) (for 28 days)85184acetaminophen (1000 mg/kg) (for 28 days)
6blood triglyceride levelSDfemale22.8mg/dlnaive control condition85185naive control condition
6blood triglyceride levelSDfemale27.7mg/dlacetaminophen (250 mg/kg) (for 28 days)85186acetaminophen (250 mg/kg) (for 28 days)
6blood triglyceride levelSDfemale44mg/dlacetaminophen (500 mg/kg) (for 28 days)85187acetaminophen (500 mg/kg) (for 28 days)
6blood triglyceride levelSDfemale31.7mg/dlacetaminophen (1000 mg/kg) (for 28 days)85188acetaminophen (1000 mg/kg) (for 28 days)
6blood triglyceride levelSDfemale32.67mg/dlnaive control condition85189naive control condition
6blood triglyceride levelSDfemale23.83mg/dlacetaminophen (1000 mg/kg) (for 28 days)85190acetaminophen (1000 mg/kg) (for 28 days)
6liver wet weightSDmale3.81gnaive control condition85191naive control condition
6liver wet weightSDmale4.31gacetaminophen (250 mg/kg) (for 28 days)85192acetaminophen (250 mg/kg) (for 28 days)
6liver wet weightSDmale4.31gacetaminophen (500 mg/kg) (for 28 days)85193acetaminophen (500 mg/kg) (for 28 days)
6liver wet weightSDmale3.65gacetaminophen (1000 mg/kg) (for 28 days)85194acetaminophen (1000 mg/kg) (for 28 days)
6liver wet weightSDmale3.18gnaive control condition85195naive control condition
6liver wet weightSDmale3.56gacetaminophen (1000 mg/kg) (for 28 days)85196acetaminophen (1000 mg/kg) (for 28 days)
6liver wet weightSDfemale3.64gnaive control condition85200naive control condition
6liver wet weightSDfemale4.06gacetaminophen (250 mg/kg) (for 28 days)85201acetaminophen (250 mg/kg) (for 28 days)
6liver wet weightSDfemale4.2gacetaminophen (500 mg/kg) (for 28 days)85202acetaminophen (500 mg/kg) (for 28 days)
6liver wet weightSDfemale3.7gacetaminophen (1000 mg/kg) (for 28 days)85203acetaminophen (1000 mg/kg) (for 28 days)
6liver wet weightSDfemale3.69gnaive control condition85204naive control condition
6liver wet weightSDfemale3.51gacetaminophen (1000 mg/kg) (for 28 days)85205acetaminophen (1000 mg/kg) (for 28 days)
6both kidneys wet weightSDmale0.89gnaive control condition85206naive control condition
6both kidneys wet weightSDmale0.88gacetaminophen (250 mg/kg) (for 28 days)85207acetaminophen (250 mg/kg) (for 28 days)
6both kidneys wet weightSDmale0.85gacetaminophen (500 mg/kg) (for 28 days)85208acetaminophen (500 mg/kg) (for 28 days)
6both kidneys wet weightSDmale0.88gacetaminophen (1000 mg/kg) (for 28 days)85209acetaminophen (1000 mg/kg) (for 28 days)
6both kidneys wet weightSDmale0.76gnaive control condition85210naive control condition
6both kidneys wet weightSDmale0.84gacetaminophen (1000 mg/kg) (for 28 days)85211acetaminophen (1000 mg/kg) (for 28 days)
6both kidneys wet weightSDfemale0.94gnaive control condition85212naive control condition
6both kidneys wet weightSDfemale0.85gacetaminophen (250 mg/kg) (for 28 days)85213acetaminophen (250 mg/kg) (for 28 days)
6both kidneys wet weightSDfemale0.88gacetaminophen (500 mg/kg) (for 28 days)85214acetaminophen (500 mg/kg) (for 28 days)
6both kidneys wet weightSDfemale0.92gacetaminophen (1000 mg/kg) (for 28 days)85215acetaminophen (1000 mg/kg) (for 28 days)
6both kidneys wet weightSDfemale0.87gnaive control condition85216naive control condition
6both kidneys wet weightSDfemale0.88gacetaminophen (1000 mg/kg) (for 28 days)85217acetaminophen (1000 mg/kg) (for 28 days)
6both lungs wet weightSDmale0.73gnaive control condition85218naive control condition
6both lungs wet weightSDmale0.72gacetaminophen (250 mg/kg) (for 28 days)85219acetaminophen (250 mg/kg) (for 28 days)
6both lungs wet weightSDmale0.68gacetaminophen (500 mg/kg) (for 28 days)85220acetaminophen (500 mg/kg) (for 28 days)
6both lungs wet weightSDmale0.77gacetaminophen (1000 mg/kg) (for 28 days)85221acetaminophen (1000 mg/kg) (for 28 days)
6both lungs wet weightSDmale0.66gnaive control condition85222naive control condition
6both lungs wet weightSDmale0.64gacetaminophen (1000 mg/kg) (for 28 days)85223acetaminophen (1000 mg/kg) (for 28 days)
6both lungs wet weightSDfemale0.81gnaive control condition85224naive control condition
6both lungs wet weightSDfemale0.76gacetaminophen (250 mg/kg) (for 28 days)85225acetaminophen (250 mg/kg) (for 28 days)
6both lungs wet weightSDfemale0.8gacetaminophen (500 mg/kg) (for 28 days)85226acetaminophen (500 mg/kg) (for 28 days)
6both lungs wet weightSDfemale0.73gacetaminophen (1000 mg/kg) (for 28 days)85227acetaminophen (1000 mg/kg) (for 28 days)
6both lungs wet weightSDfemale0.79gnaive control condition85228naive control condition
6both lungs wet weightSDfemale0.74gacetaminophen (1000 mg/kg) (for 28 days)85229acetaminophen (1000 mg/kg) (for 28 days)
6heart wet weightSDmale0.39gnaive control condition85230naive control condition
6heart wet weightSDmale0.37gacetaminophen (250 mg/kg) (for 28 days)85231acetaminophen (250 mg/kg) (for 28 days)
6heart wet weightSDmale0.37gacetaminophen (500 mg/kg) (for 28 days)85232acetaminophen (500 mg/kg) (for 28 days)
6heart wet weightSDmale0.37gacetaminophen (1000 mg/kg) (for 28 days)85233acetaminophen (1000 mg/kg) (for 28 days)
6heart wet weightSDmale0.33gnaive control condition85234naive control condition
6heart wet weightSDmale0.36gacetaminophen (1000 mg/kg) (for 28 days)85235acetaminophen (1000 mg/kg) (for 28 days)
6heart wet weightSDfemale0.4gnaive control condition85236naive control condition
6heart wet weightSDfemale0.41gacetaminophen (250 mg/kg) (for 28 days)85237acetaminophen (250 mg/kg) (for 28 days)
6heart wet weightSDfemale0.42gacetaminophen (500 mg/kg) (for 28 days)85238acetaminophen (500 mg/kg) (for 28 days)
6heart wet weightSDfemale0.42gacetaminophen (1000 mg/kg) (for 28 days)85239acetaminophen (1000 mg/kg) (for 28 days)
6heart wet weightSDfemale0.44gnaive control condition85240naive control condition
6heart wet weightSDmale0.41gacetaminophen (1000 mg/kg) (for 28 days)85241acetaminophen (1000 mg/kg) (for 28 days)
6spleen wet weightSDmale0.22gnaive control condition85242naive control condition
6spleen wet weightSDmale0.29gacetaminophen (250 mg/kg) (for 28 days)85243acetaminophen (250 mg/kg) (for 28 days)
6spleen wet weightSDmale0.2gacetaminophen (500 mg/kg) (for 28 days)85244acetaminophen (500 mg/kg) (for 28 days)
6spleen wet weightSDmale0.21gacetaminophen (1000 mg/kg) (for 28 days)85245acetaminophen (1000 mg/kg) (for 28 days)
6spleen wet weightSDmale0.17gnaive control condition85246naive control condition
6spleen wet weightSDmale0.21gacetaminophen (1000 mg/kg) (for 28 days)85247acetaminophen (1000 mg/kg) (for 28 days)
6spleen wet weightSDfemale0.24gnaive control condition85248naive control condition
6spleen wet weightSDfemale0.24gacetaminophen (250 mg/kg) (for 28 days)85249acetaminophen (250 mg/kg) (for 28 days)
6spleen wet weightSDfemale0.26gacetaminophen (500 mg/kg) (for 28 days)85250acetaminophen (500 mg/kg) (for 28 days)
6spleen wet weightSDfemale0.24gnaive control condition85251naive control condition
6spleen wet weightSDfemale0.24gacetaminophen (1000 mg/kg) (for 28 days)85252acetaminophen (1000 mg/kg) (for 28 days)
6spleen wet weightSDfemale0.23gacetaminophen (1000 mg/kg) (for 28 days)85253acetaminophen (1000 mg/kg) (for 28 days)
6brain wet weightSDmale0.77gnaive control condition85254naive control condition
6brain wet weightSDmale0.72gacetaminophen (250 mg/kg) (for 28 days)85255acetaminophen (250 mg/kg) (for 28 days)
6brain wet weightSDmale0.74gacetaminophen (500 mg/kg) (for 28 days)85256acetaminophen (500 mg/kg) (for 28 days)
6brain wet weightSDmale0.75gacetaminophen (1000 mg/kg) (for 28 days)85257acetaminophen (1000 mg/kg) (for 28 days)
6brain wet weightSDmale0.67gnaive control condition85258naive control condition
6brain wet weightSDmale0.68gacetaminophen (1000 mg/kg) (for 28 days)85259acetaminophen (1000 mg/kg) (for 28 days)
6brain wet weightSDfemale1.1gnaive control condition85260naive control condition
6brain wet weightSDfemale1.03gacetaminophen (250 mg/kg) (for 28 days)85261acetaminophen (250 mg/kg) (for 28 days)
6brain wet weightSDfemale1.11gacetaminophen (500 mg/kg) (for 28 days)85262acetaminophen (500 mg/kg) (for 28 days)
6brain wet weightSDfemale1.17gacetaminophen (1000 mg/kg) (for 28 days)85263acetaminophen (1000 mg/kg) (for 28 days)
6brain wet weightSDfemale1.09gnaive control condition85264naive control condition
6brain wet weightSDfemale1.09gacetaminophen (1000 mg/kg) (for 28 days)85265acetaminophen (1000 mg/kg) (for 28 days)
6adrenal gland wet weightSDmale0.02gnaive control condition85266naive control condition
6adrenal gland wet weightSDmale0.02gacetaminophen (250 mg/kg) (for 28 days)85267acetaminophen (250 mg/kg) (for 28 days)
6adrenal gland wet weightSDmale0.02gacetaminophen (500 mg/kg) (for 28 days)85268acetaminophen (500 mg/kg) (for 28 days)
6adrenal gland wet weightSDmale0.02gacetaminophen (1000 mg/kg) (for 28 days)85269acetaminophen (1000 mg/kg) (for 28 days)
6adrenal gland wet weightSDmale0.02gnaive control condition85270naive control condition
6adrenal gland wet weightSDmale0.02gacetaminophen (1000 mg/kg) (for 28 days)85271acetaminophen (1000 mg/kg) (for 28 days)
6adrenal gland wet weightSDfemale0.04gnaive control condition85272naive control condition
6adrenal gland wet weightSDfemale0.04gacetaminophen (250 mg/kg) (for 28 days)85273acetaminophen (250 mg/kg) (for 28 days)
6adrenal gland wet weightSDfemale0.04gacetaminophen (500 mg/kg) (for 28 days)85274acetaminophen (500 mg/kg) (for 28 days)
6adrenal gland wet weightSDfemale0.04gacetaminophen (1000 mg/kg) (for 28 days)85275acetaminophen (1000 mg/kg) (for 28 days)
6adrenal gland wet weightSDfemale0.04gnaive control condition85276naive control condition
6adrenal gland wet weightSDfemale0.04gacetaminophen (1000 mg/kg) (for 28 days)85277acetaminophen (1000 mg/kg) (for 28 days)
6testis wet weightSDmale1.17gnaive control condition85278naive control condition
6testis wet weightSDmale1.19gacetaminophen (250 mg/kg) (for 28 days)85279acetaminophen (250 mg/kg) (for 28 days)
6testis wet weightSDmale1.17gacetaminophen (500 mg/kg) (for 28 days)85280acetaminophen (500 mg/kg) (for 28 days)
6testis wet weightSDmale1.03gacetaminophen (1000 mg/kg) (for 28 days)85281acetaminophen (1000 mg/kg) (for 28 days)
6testis wet weightSDmale1gnaive control condition85282naive control condition
6testis wet weightSDmale1.01gacetaminophen (1000 mg/kg) (for 28 days)85283acetaminophen (1000 mg/kg) (for 28 days)
6uterus wet weightSDfemale0.35gnaive control condition85284naive control condition
6uterus wet weightSDfemale0.28gacetaminophen (250 mg/kg) (for 28 days)85285acetaminophen (250 mg/kg) (for 28 days)
6uterus wet weightSDfemale0.45gacetaminophen (500 mg/kg) (for 28 days)85286acetaminophen (500 mg/kg) (for 28 days)
6uterus wet weightSDfemale0.38gacetaminophen (1000 mg/kg) (for 28 days)85287acetaminophen (1000 mg/kg) (for 28 days)
6uterus wet weightSDfemale0.35gnaive control condition85288naive control condition
6uterus wet weightSDfemale0.27gacetaminophen (1000 mg/kg) (for 28 days)85289acetaminophen (1000 mg/kg) (for 28 days)
16duration of loss of righting reflexSDfemale178sisoflurane (4 %) (between 0.1 and 0.2 hours) then carprofen (5 mg/kg) (for 0 hours)98198isoflurane (4 %) (between 0.1 and 0.2 hours)carprofen (5 mg/kg) (for 0 hours)
14duration of loss of righting reflexSDfemale129sisoflurane (4 %) (between 0.1 and 0.2 hours) then carprofen (5 mg/kg) (for 0 hours) then coronal plane rotational acceleration of the head (210 krad/s2) (for 0 hours) and coronal plane rotational acceleration of the head (140 rad/s2) (for 0 hours)98199isoflurane (4 %) (between 0.1 and 0.2 hours)carprofen (5 mg/kg) (for 0 hours)coronal plane rotational acceleration of the head (210 krad/s2) (for 0 hours)coronal plane rotational acceleration of the head (140 rad/s2) (for 0 hours)
38duration of loss of righting reflexSDfemale181sisoflurane (4 %) (between 0.1 and 0.2 hours) then carprofen (5 mg/kg) (for 0 hours) then coronal plane rotational acceleration of the head (210 krad/s2) (for 0 hours) and coronal plane rotational acceleration of the head (250 rad/s2) (for 0 hours)98200isoflurane (4 %) (between 0.1 and 0.2 hours)carprofen (5 mg/kg) (for 0 hours)coronal plane rotational acceleration of the head (210 krad/s2) (for 0 hours)coronal plane rotational acceleration of the head (250 rad/s2) (for 0 hours)
34duration of loss of righting reflexSDfemale228sisoflurane (4 %) (between 0.1 and 0.2 hours) then carprofen (5 mg/kg) (for 0 hours) then coronal plane rotational acceleration of the head (360 krad/s2) (for 0 hours) and coronal plane rotational acceleration of the head (250 rad/s2) (for 0 hours)98201isoflurane (4 %) (between 0.1 and 0.2 hours)carprofen (5 mg/kg) (for 0 hours)coronal plane rotational acceleration of the head (360 krad/s2) (for 0 hours)coronal plane rotational acceleration of the head (250 rad/s2) (for 0 hours)
25duration of loss of righting reflexSDfemale223sisoflurane (4 %) (between 0.1 and 0.2 hours) then carprofen (5 mg/kg) (for 0 hours) then coronal plane rotational acceleration of the head (360 krad/s2) (for 0 hours) and coronal plane rotational acceleration of the head (380 rad/s2) (for 0 hours)98202isoflurane (4 %) (between 0.1 and 0.2 hours)carprofen (5 mg/kg) (for 0 hours)coronal plane rotational acceleration of the head (360 krad/s2) (for 0 hours)coronal plane rotational acceleration of the head (380 rad/s2) (for 0 hours)
19duration of loss of righting reflexSDfemale222sisoflurane (4 %) (between 0.1 and 0.2 hours) then carprofen (5 mg/kg) (for 0 hours) then coronal plane rotational acceleration of the head (500 krad/s2) (for 0 hours) and coronal plane rotational acceleration of the head (615 rad/s2) (for 0 hours)98203isoflurane (4 %) (between 0.1 and 0.2 hours)carprofen (5 mg/kg) (for 0 hours)coronal plane rotational acceleration of the head (500 krad/s2) (for 0 hours)coronal plane rotational acceleration of the head (615 rad/s2) (for 0 hours)
8total horizontal distance resulting from voluntary locomotion in an experimental apparatusSDfemale724cmisoflurane (4 %) (between 0.1 and 0.2 hours) then carprofen (5 mg/kg) (for 0 hours)98204isoflurane (4 %) (between 0.1 and 0.2 hours)carprofen (5 mg/kg) (for 0 hours)
14total horizontal distance resulting from voluntary locomotion in an experimental apparatusSDfemale954cmisoflurane (4 %) (between 0.1 and 0.2 hours) then carprofen (5 mg/kg) (for 0 hours) then coronal plane rotational acceleration of the head (210 krad/s2) (for 0 hours) and coronal plane rotational acceleration of the head (140 rad/s2) (for 0 hours)98211isoflurane (4 %) (between 0.1 and 0.2 hours)carprofen (5 mg/kg) (for 0 hours)coronal plane rotational acceleration of the head (210 krad/s2) (for 0 hours)coronal plane rotational acceleration of the head (140 rad/s2) (for 0 hours)
21total horizontal distance resulting from voluntary locomotion in an experimental apparatusSDfemale1241cmisoflurane (4 %) (between 0.1 and 0.2 hours) then carprofen (5 mg/kg) (for 0 hours) then coronal plane rotational acceleration of the head (210 krad/s2) (for 0 hours) and coronal plane rotational acceleration of the head (250 rad/s2) (for 0 hours)98212isoflurane (4 %) (between 0.1 and 0.2 hours)carprofen (5 mg/kg) (for 0 hours)coronal plane rotational acceleration of the head (210 krad/s2) (for 0 hours)coronal plane rotational acceleration of the head (250 rad/s2) (for 0 hours)
23total horizontal distance resulting from voluntary locomotion in an experimental apparatusSDfemale1131cmisoflurane (4 %) (between 0.1 and 0.2 hours) then carprofen (5 mg/kg) (for 0 hours) then coronal plane rotational acceleration of the head (360 krad/s2) (for 0 hours) and coronal plane rotational acceleration of the head (250 rad/s2) (for 0 hours)98213isoflurane (4 %) (between 0.1 and 0.2 hours)carprofen (5 mg/kg) (for 0 hours)coronal plane rotational acceleration of the head (360 krad/s2) (for 0 hours)coronal plane rotational acceleration of the head (250 rad/s2) (for 0 hours)
16total horizontal distance resulting from voluntary locomotion in an experimental apparatusSDfemale1263cmisoflurane (4 %) (between 0.1 and 0.2 hours) then carprofen (5 mg/kg) (for 0 hours) then coronal plane rotational acceleration of the head (360 krad/s2) (for 0 hours) and coronal plane rotational acceleration of the head (380 rad/s2) (for 0 hours)98214isoflurane (4 %) (between 0.1 and 0.2 hours)carprofen (5 mg/kg) (for 0 hours)coronal plane rotational acceleration of the head (360 krad/s2) (for 0 hours)coronal plane rotational acceleration of the head (380 rad/s2) (for 0 hours)
10total horizontal distance resulting from voluntary locomotion in an experimental apparatusSDfemale1334cmisoflurane (4 %) (between 0.1 and 0.2 hours) then carprofen (5 mg/kg) (for 0 hours) then coronal plane rotational acceleration of the head (500 krad/s2) (for 0 hours) and coronal plane rotational acceleration of the head (615 rad/s2) (for 0 hours)98215isoflurane (4 %) (between 0.1 and 0.2 hours)carprofen (5 mg/kg) (for 0 hours)coronal plane rotational acceleration of the head (500 krad/s2) (for 0 hours)coronal plane rotational acceleration of the head (615 rad/s2) (for 0 hours)
8number of entries into a discrete space in an experimental apparatusSDfemale15.6isoflurane (4 %) (between 0.1 and 0.2 hours) then carprofen (5 mg/kg) (for 0 hours)98216isoflurane (4 %) (between 0.1 and 0.2 hours)carprofen (5 mg/kg) (for 0 hours)
14number of entries into a discrete space in an experimental apparatusSDfemale22.8isoflurane (4 %) (between 0.1 and 0.2 hours) then carprofen (5 mg/kg) (for 0 hours) then coronal plane rotational acceleration of the head (210 krad/s2) (for 0 hours) and coronal plane rotational acceleration of the head (140 rad/s2) (for 0 hours)98217isoflurane (4 %) (between 0.1 and 0.2 hours)carprofen (5 mg/kg) (for 0 hours)coronal plane rotational acceleration of the head (210 krad/s2) (for 0 hours)coronal plane rotational acceleration of the head (140 rad/s2) (for 0 hours)
21number of entries into a discrete space in an experimental apparatusSDfemale29.7isoflurane (4 %) (between 0.1 and 0.2 hours) then carprofen (5 mg/kg) (for 0 hours) then coronal plane rotational acceleration of the head (210 krad/s2) (for 0 hours) and coronal plane rotational acceleration of the head (250 rad/s2) (for 0 hours)98218isoflurane (4 %) (between 0.1 and 0.2 hours)carprofen (5 mg/kg) (for 0 hours)coronal plane rotational acceleration of the head (210 krad/s2) (for 0 hours)coronal plane rotational acceleration of the head (250 rad/s2) (for 0 hours)
23number of entries into a discrete space in an experimental apparatusSDfemale26.8isoflurane (4 %) (between 0.1 and 0.2 hours) then carprofen (5 mg/kg) (for 0 hours) then coronal plane rotational acceleration of the head (360 krad/s2) (for 0 hours) and coronal plane rotational acceleration of the head (250 rad/s2) (for 0 hours)98219isoflurane (4 %) (between 0.1 and 0.2 hours)carprofen (5 mg/kg) (for 0 hours)coronal plane rotational acceleration of the head (360 krad/s2) (for 0 hours)coronal plane rotational acceleration of the head (250 rad/s2) (for 0 hours)
16number of entries into a discrete space in an experimental apparatusSDfemale34isoflurane (4 %) (between 0.1 and 0.2 hours) then carprofen (5 mg/kg) (for 0 hours) then coronal plane rotational acceleration of the head (360 krad/s2) (for 0 hours) and coronal plane rotational acceleration of the head (380 rad/s2) (for 0 hours)98220isoflurane (4 %) (between 0.1 and 0.2 hours)carprofen (5 mg/kg) (for 0 hours)coronal plane rotational acceleration of the head (360 krad/s2) (for 0 hours)coronal plane rotational acceleration of the head (380 rad/s2) (for 0 hours)
10number of entries into a discrete space in an experimental apparatusSDfemale35.3isoflurane (4 %) (between 0.1 and 0.2 hours) then carprofen (5 mg/kg) (for 0 hours) then coronal plane rotational acceleration of the head (500 krad/s2) (for 0 hours) and coronal plane rotational acceleration of the head (615 rad/s2) (for 0 hours)98221isoflurane (4 %) (between 0.1 and 0.2 hours)carprofen (5 mg/kg) (for 0 hours)coronal plane rotational acceleration of the head (500 krad/s2) (for 0 hours)coronal plane rotational acceleration of the head (615 rad/s2) (for 0 hours)
8amount of experiment time spent in a discrete space in an experimental apparatusSDfemale42.2sisoflurane (4 %) (between 0.1 and 0.2 hours) then carprofen (5 mg/kg) (for 0 hours)98222isoflurane (4 %) (between 0.1 and 0.2 hours)carprofen (5 mg/kg) (for 0 hours)
14amount of experiment time spent in a discrete space in an experimental apparatusSDfemale58.7sisoflurane (4 %) (between 0.1 and 0.2 hours) then carprofen (5 mg/kg) (for 0 hours) then coronal plane rotational acceleration of the head (210 krad/s2) (for 0 hours) and coronal plane rotational acceleration of the head (140 rad/s2) (for 0 hours)98223isoflurane (4 %) (between 0.1 and 0.2 hours)carprofen (5 mg/kg) (for 0 hours)coronal plane rotational acceleration of the head (210 krad/s2) (for 0 hours)coronal plane rotational acceleration of the head (140 rad/s2) (for 0 hours)
21amount of experiment time spent in a discrete space in an experimental apparatusSDfemale75.6sisoflurane (4 %) (between 0.1 and 0.2 hours) then carprofen (5 mg/kg) (for 0 hours) then coronal plane rotational acceleration of the head (210 krad/s2) (for 0 hours) and coronal plane rotational acceleration of the head (250 rad/s2) (for 0 hours)98224isoflurane (4 %) (between 0.1 and 0.2 hours)carprofen (5 mg/kg) (for 0 hours)coronal plane rotational acceleration of the head (210 krad/s2) (for 0 hours)coronal plane rotational acceleration of the head (250 rad/s2) (for 0 hours)
23amount of experiment time spent in a discrete space in an experimental apparatusSDfemale50.7sisoflurane (4 %) (between 0.1 and 0.2 hours) then carprofen (5 mg/kg) (for 0 hours) then coronal plane rotational acceleration of the head (360 krad/s2) (for 0 hours) and coronal plane rotational acceleration of the head (250 rad/s2) (for 0 hours)98225isoflurane (4 %) (between 0.1 and 0.2 hours)carprofen (5 mg/kg) (for 0 hours)coronal plane rotational acceleration of the head (360 krad/s2) (for 0 hours)coronal plane rotational acceleration of the head (250 rad/s2) (for 0 hours)
16amount of experiment time spent in a discrete space in an experimental apparatusSDfemale78.4sisoflurane (4 %) (between 0.1 and 0.2 hours) then carprofen (5 mg/kg) (for 0 hours) then coronal plane rotational acceleration of the head (360 krad/s2) (for 0 hours) and coronal plane rotational acceleration of the head (380 rad/s2) (for 0 hours)98226isoflurane (4 %) (between 0.1 and 0.2 hours)carprofen (5 mg/kg) (for 0 hours)coronal plane rotational acceleration of the head (360 krad/s2) (for 0 hours)coronal plane rotational acceleration of the head (380 rad/s2) (for 0 hours)
10amount of experiment time spent in a discrete space in an experimental apparatusSDfemale98.1sisoflurane (4 %) (between 0.1 and 0.2 hours) then carprofen (5 mg/kg) (for 0 hours) then coronal plane rotational acceleration of the head (500 krad/s2) (for 0 hours) and coronal plane rotational acceleration of the head (615 rad/s2) (for 0 hours)98227isoflurane (4 %) (between 0.1 and 0.2 hours)carprofen (5 mg/kg) (for 0 hours)coronal plane rotational acceleration of the head (500 krad/s2) (for 0 hours)coronal plane rotational acceleration of the head (615 rad/s2) (for 0 hours)
8time to locate a hidden target platform in an experimental apparatusSDfemale48.8sisoflurane (4 %) (between 0.1 and 0.2 hours) then carprofen (5 mg/kg) (for 0 hours)98228isoflurane (4 %) (between 0.1 and 0.2 hours)carprofen (5 mg/kg) (for 0 hours)
8time to locate a hidden target platform in an experimental apparatusSDfemale17.8sisoflurane (4 %) (between 0.1 and 0.2 hours) then carprofen (5 mg/kg) (for 0 hours)98229isoflurane (4 %) (between 0.1 and 0.2 hours)carprofen (5 mg/kg) (for 0 hours)
8time to locate a hidden target platform in an experimental apparatusSDfemale21.2sisoflurane (4 %) (between 0.1 and 0.2 hours) then carprofen (5 mg/kg) (for 0 hours)98230isoflurane (4 %) (between 0.1 and 0.2 hours)carprofen (5 mg/kg) (for 0 hours)
14time to locate a hidden target platform in an experimental apparatusSDfemale37.5sisoflurane (4 %) (between 0.1 and 0.2 hours) then carprofen (5 mg/kg) (for 0 hours) then coronal plane rotational acceleration of the head (210 krad/s2) (for 0 hours) and coronal plane rotational acceleration of the head (140 rad/s2) (for 0 hours)98232isoflurane (4 %) (between 0.1 and 0.2 hours)carprofen (5 mg/kg) (for 0 hours)coronal plane rotational acceleration of the head (210 krad/s2) (for 0 hours)coronal plane rotational acceleration of the head (140 rad/s2) (for 0 hours)
14time to locate a hidden target platform in an experimental apparatusSDfemale15.8sisoflurane (4 %) (between 0.1 and 0.2 hours) then carprofen (5 mg/kg) (for 0 hours) then coronal plane rotational acceleration of the head (210 krad/s2) (for 0 hours) and coronal plane rotational acceleration of the head (140 rad/s2) (for 0 hours)98233isoflurane (4 %) (between 0.1 and 0.2 hours)carprofen (5 mg/kg) (for 0 hours)coronal plane rotational acceleration of the head (210 krad/s2) (for 0 hours)coronal plane rotational acceleration of the head (140 rad/s2) (for 0 hours)
14time to locate a hidden target platform in an experimental apparatusSDfemale18sisoflurane (4 %) (between 0.1 and 0.2 hours) then carprofen (5 mg/kg) (for 0 hours) then coronal plane rotational acceleration of the head (210 krad/s2) (for 0 hours) and coronal plane rotational acceleration of the head (140 rad/s2) (for 0 hours)98234isoflurane (4 %) (between 0.1 and 0.2 hours)carprofen (5 mg/kg) (for 0 hours)coronal plane rotational acceleration of the head (210 krad/s2) (for 0 hours)coronal plane rotational acceleration of the head (140 rad/s2) (for 0 hours)
21time to locate a hidden target platform in an experimental apparatusSDfemale34.5sisoflurane (4 %) (between 0.1 and 0.2 hours) then carprofen (5 mg/kg) (for 0 hours) then coronal plane rotational acceleration of the head (210 krad/s2) (for 0 hours) and coronal plane rotational acceleration of the head (250 rad/s2) (for 0 hours)98235isoflurane (4 %) (between 0.1 and 0.2 hours)carprofen (5 mg/kg) (for 0 hours)coronal plane rotational acceleration of the head (210 krad/s2) (for 0 hours)coronal plane rotational acceleration of the head (250 rad/s2) (for 0 hours)
21time to locate a hidden target platform in an experimental apparatusSDfemale23.1sisoflurane (4 %) (between 0.1 and 0.2 hours) then carprofen (5 mg/kg) (for 0 hours) then coronal plane rotational acceleration of the head (210 krad/s2) (for 0 hours) and coronal plane rotational acceleration of the head (250 rad/s2) (for 0 hours)98236isoflurane (4 %) (between 0.1 and 0.2 hours)carprofen (5 mg/kg) (for 0 hours)coronal plane rotational acceleration of the head (210 krad/s2) (for 0 hours)coronal plane rotational acceleration of the head (250 rad/s2) (for 0 hours)
21time to locate a hidden target platform in an experimental apparatusSDfemale21.2sisoflurane (4 %) (between 0.1 and 0.2 hours) then carprofen (5 mg/kg) (for 0 hours) then coronal plane rotational acceleration of the head (210 krad/s2) (for 0 hours) and coronal plane rotational acceleration of the head (250 rad/s2) (for 0 hours)98237isoflurane (4 %) (between 0.1 and 0.2 hours)carprofen (5 mg/kg) (for 0 hours)coronal plane rotational acceleration of the head (210 krad/s2) (for 0 hours)coronal plane rotational acceleration of the head (250 rad/s2) (for 0 hours)
23time to locate a hidden target platform in an experimental apparatusSDfemale37.8sisoflurane (4 %) (between 0.1 and 0.2 hours) then carprofen (5 mg/kg) (for 0 hours) then coronal plane rotational acceleration of the head (360 krad/s2) (for 0 hours) and coronal plane rotational acceleration of the head (250 rad/s2) (for 0 hours)98238isoflurane (4 %) (between 0.1 and 0.2 hours)carprofen (5 mg/kg) (for 0 hours)coronal plane rotational acceleration of the head (360 krad/s2) (for 0 hours)coronal plane rotational acceleration of the head (250 rad/s2) (for 0 hours)
23time to locate a hidden target platform in an experimental apparatusSDfemale21.3sisoflurane (4 %) (between 0.1 and 0.2 hours) then carprofen (5 mg/kg) (for 0 hours) then coronal plane rotational acceleration of the head (360 krad/s2) (for 0 hours) and coronal plane rotational acceleration of the head (250 rad/s2) (for 0 hours)98239isoflurane (4 %) (between 0.1 and 0.2 hours)carprofen (5 mg/kg) (for 0 hours)coronal plane rotational acceleration of the head (360 krad/s2) (for 0 hours)coronal plane rotational acceleration of the head (250 rad/s2) (for 0 hours)
23time to locate a hidden target platform in an experimental apparatusSDfemale18.9sisoflurane (4 %) (between 0.1 and 0.2 hours) then carprofen (5 mg/kg) (for 0 hours) then coronal plane rotational acceleration of the head (360 krad/s2) (for 0 hours) and coronal plane rotational acceleration of the head (250 rad/s2) (for 0 hours)98240isoflurane (4 %) (between 0.1 and 0.2 hours)carprofen (5 mg/kg) (for 0 hours)coronal plane rotational acceleration of the head (360 krad/s2) (for 0 hours)coronal plane rotational acceleration of the head (250 rad/s2) (for 0 hours)
16time to locate a hidden target platform in an experimental apparatusSDfemale38.2sisoflurane (4 %) (between 0.1 and 0.2 hours) then carprofen (5 mg/kg) (for 0 hours) then coronal plane rotational acceleration of the head (360 krad/s2) (for 0 hours) and coronal plane rotational acceleration of the head (380 rad/s2) (for 0 hours)98241isoflurane (4 %) (between 0.1 and 0.2 hours)carprofen (5 mg/kg) (for 0 hours)coronal plane rotational acceleration of the head (360 krad/s2) (for 0 hours)coronal plane rotational acceleration of the head (380 rad/s2) (for 0 hours)
16time to locate a hidden target platform in an experimental apparatusSDfemale21.5sisoflurane (4 %) (between 0.1 and 0.2 hours) then carprofen (5 mg/kg) (for 0 hours) then coronal plane rotational acceleration of the head (360 krad/s2) (for 0 hours) and coronal plane rotational acceleration of the head (380 rad/s2) (for 0 hours)98242isoflurane (4 %) (between 0.1 and 0.2 hours)carprofen (5 mg/kg) (for 0 hours)coronal plane rotational acceleration of the head (360 krad/s2) (for 0 hours)coronal plane rotational acceleration of the head (380 rad/s2) (for 0 hours)
16time to locate a hidden target platform in an experimental apparatusSDfemale14.9sisoflurane (4 %) (between 0.1 and 0.2 hours) then carprofen (5 mg/kg) (for 0 hours) then coronal plane rotational acceleration of the head (360 krad/s2) (for 0 hours) and coronal plane rotational acceleration of the head (380 rad/s2) (for 0 hours)98243isoflurane (4 %) (between 0.1 and 0.2 hours)carprofen (5 mg/kg) (for 0 hours)coronal plane rotational acceleration of the head (360 krad/s2) (for 0 hours)coronal plane rotational acceleration of the head (380 rad/s2) (for 0 hours)
10time to locate a hidden target platform in an experimental apparatusSDfemale36sisoflurane (4 %) (between 0.1 and 0.2 hours) then carprofen (5 mg/kg) (for 0 hours) then coronal plane rotational acceleration of the head (500 krad/s2) (for 0 hours) and coronal plane rotational acceleration of the head (615 rad/s2) (for 0 hours)98244isoflurane (4 %) (between 0.1 and 0.2 hours)carprofen (5 mg/kg) (for 0 hours)coronal plane rotational acceleration of the head (500 krad/s2) (for 0 hours)coronal plane rotational acceleration of the head (615 rad/s2) (for 0 hours)
10time to locate a hidden target platform in an experimental apparatusSDfemale15.8sisoflurane (4 %) (between 0.1 and 0.2 hours) then carprofen (5 mg/kg) (for 0 hours) then coronal plane rotational acceleration of the head (500 krad/s2) (for 0 hours) and coronal plane rotational acceleration of the head (615 rad/s2) (for 0 hours)98245isoflurane (4 %) (between 0.1 and 0.2 hours)carprofen (5 mg/kg) (for 0 hours)coronal plane rotational acceleration of the head (500 krad/s2) (for 0 hours)coronal plane rotational acceleration of the head (615 rad/s2) (for 0 hours)
10time to locate a hidden target platform in an experimental apparatusSDfemale15.2sisoflurane (4 %) (between 0.1 and 0.2 hours) then carprofen (5 mg/kg) (for 0 hours) then coronal plane rotational acceleration of the head (500 krad/s2) (for 0 hours) and coronal plane rotational acceleration of the head (615 rad/s2) (for 0 hours)98246isoflurane (4 %) (between 0.1 and 0.2 hours)carprofen (5 mg/kg) (for 0 hours)coronal plane rotational acceleration of the head (500 krad/s2) (for 0 hours)coronal plane rotational acceleration of the head (615 rad/s2) (for 0 hours)
8total horizontal distance resulting from voluntary locomotion in an experimental apparatusSDfemale1317cmisoflurane (4 %) (between 0.1 and 0.2 hours) then carprofen (5 mg/kg) (for 0 hours)98247isoflurane (4 %) (between 0.1 and 0.2 hours)carprofen (5 mg/kg) (for 0 hours)
17total horizontal distance resulting from voluntary locomotion in an experimental apparatusSDfemale915cmisoflurane (4 %) (between 0.1 and 0.2 hours) then carprofen (5 mg/kg) (for 0 hours) then coronal plane rotational acceleration of the head (210 krad/s2) (for 0 hours) and coronal plane rotational acceleration of the head (250 rad/s2) (for 0 hours)98248isoflurane (4 %) (between 0.1 and 0.2 hours)carprofen (5 mg/kg) (for 0 hours)coronal plane rotational acceleration of the head (210 krad/s2) (for 0 hours)coronal plane rotational acceleration of the head (250 rad/s2) (for 0 hours)
11total horizontal distance resulting from voluntary locomotion in an experimental apparatusSDfemale1168cmisoflurane (4 %) (between 0.1 and 0.2 hours) then carprofen (5 mg/kg) (for 0 hours) then coronal plane rotational acceleration of the head (360 krad/s2) (for 0 hours) and coronal plane rotational acceleration of the head (250 rad/s2) (for 0 hours)98249isoflurane (4 %) (between 0.1 and 0.2 hours)carprofen (5 mg/kg) (for 0 hours)coronal plane rotational acceleration of the head (360 krad/s2) (for 0 hours)coronal plane rotational acceleration of the head (250 rad/s2) (for 0 hours)
9total horizontal distance resulting from voluntary locomotion in an experimental apparatusSDfemale1101cmisoflurane (4 %) (between 0.1 and 0.2 hours) then carprofen (5 mg/kg) (for 0 hours) then coronal plane rotational acceleration of the head (360 krad/s2) (for 0 hours) and coronal plane rotational acceleration of the head (380 rad/s2) (for 0 hours)98250isoflurane (4 %) (between 0.1 and 0.2 hours)carprofen (5 mg/kg) (for 0 hours)coronal plane rotational acceleration of the head (360 krad/s2) (for 0 hours)coronal plane rotational acceleration of the head (380 rad/s2) (for 0 hours)
9total horizontal distance resulting from voluntary locomotion in an experimental apparatusSDfemale777cmisoflurane (4 %) (between 0.1 and 0.2 hours) then carprofen (5 mg/kg) (for 0 hours) then coronal plane rotational acceleration of the head (500 krad/s2) (for 0 hours) and coronal plane rotational acceleration of the head (615 rad/s2) (for 0 hours)98251isoflurane (4 %) (between 0.1 and 0.2 hours)carprofen (5 mg/kg) (for 0 hours)coronal plane rotational acceleration of the head (500 krad/s2) (for 0 hours)coronal plane rotational acceleration of the head (615 rad/s2) (for 0 hours)
8number of entries into a discrete space in an experimental apparatusSDfemale29.3isoflurane (4 %) (between 0.1 and 0.2 hours) then carprofen (5 mg/kg) (for 0 hours)98252isoflurane (4 %) (between 0.1 and 0.2 hours)carprofen (5 mg/kg) (for 0 hours)
17number of entries into a discrete space in an experimental apparatusSDfemale23.1isoflurane (4 %) (between 0.1 and 0.2 hours) then carprofen (5 mg/kg) (for 0 hours) then coronal plane rotational acceleration of the head (210 krad/s2) (for 0 hours) and coronal plane rotational acceleration of the head (250 rad/s2) (for 0 hours)98253isoflurane (4 %) (between 0.1 and 0.2 hours)carprofen (5 mg/kg) (for 0 hours)coronal plane rotational acceleration of the head (210 krad/s2) (for 0 hours)coronal plane rotational acceleration of the head (250 rad/s2) (for 0 hours)
11number of entries into a discrete space in an experimental apparatusSDfemale1168isoflurane (4 %) (between 0.1 and 0.2 hours) then carprofen (5 mg/kg) (for 0 hours) then coronal plane rotational acceleration of the head (360 krad/s2) (for 0 hours) and coronal plane rotational acceleration of the head (250 rad/s2) (for 0 hours)98254isoflurane (4 %) (between 0.1 and 0.2 hours)carprofen (5 mg/kg) (for 0 hours)coronal plane rotational acceleration of the head (360 krad/s2) (for 0 hours)coronal plane rotational acceleration of the head (250 rad/s2) (for 0 hours)
9number of entries into a discrete space in an experimental apparatusSDfemale24.5isoflurane (4 %) (between 0.1 and 0.2 hours) then carprofen (5 mg/kg) (for 0 hours) then coronal plane rotational acceleration of the head (360 krad/s2) (for 0 hours) and coronal plane rotational acceleration of the head (380 rad/s2) (for 0 hours)98255isoflurane (4 %) (between 0.1 and 0.2 hours)carprofen (5 mg/kg) (for 0 hours)coronal plane rotational acceleration of the head (360 krad/s2) (for 0 hours)coronal plane rotational acceleration of the head (380 rad/s2) (for 0 hours)
9number of entries into a discrete space in an experimental apparatusSDfemale18.4isoflurane (4 %) (between 0.1 and 0.2 hours) then carprofen (5 mg/kg) (for 0 hours) then coronal plane rotational acceleration of the head (500 krad/s2) (for 0 hours) and coronal plane rotational acceleration of the head (615 rad/s2) (for 0 hours)98256isoflurane (4 %) (between 0.1 and 0.2 hours)carprofen (5 mg/kg) (for 0 hours)coronal plane rotational acceleration of the head (500 krad/s2) (for 0 hours)coronal plane rotational acceleration of the head (615 rad/s2) (for 0 hours)
8amount of experiment time spent in a discrete space in an experimental apparatusSDfemale65.1sisoflurane (4 %) (between 0.1 and 0.2 hours) then carprofen (5 mg/kg) (for 0 hours)98257isoflurane (4 %) (between 0.1 and 0.2 hours)carprofen (5 mg/kg) (for 0 hours)
17amount of experiment time spent in a discrete space in an experimental apparatusSDfemale64.9sisoflurane (4 %) (between 0.1 and 0.2 hours) then carprofen (5 mg/kg) (for 0 hours) then coronal plane rotational acceleration of the head (210 krad/s2) (for 0 hours) and coronal plane rotational acceleration of the head (250 rad/s2) (for 0 hours)98258isoflurane (4 %) (between 0.1 and 0.2 hours)carprofen (5 mg/kg) (for 0 hours)coronal plane rotational acceleration of the head (210 krad/s2) (for 0 hours)coronal plane rotational acceleration of the head (250 rad/s2) (for 0 hours)
11amount of experiment time spent in a discrete space in an experimental apparatusSDfemale90.8sisoflurane (4 %) (between 0.1 and 0.2 hours) then carprofen (5 mg/kg) (for 0 hours) then coronal plane rotational acceleration of the head (360 krad/s2) (for 0 hours) and coronal plane rotational acceleration of the head (250 rad/s2) (for 0 hours)98259isoflurane (4 %) (between 0.1 and 0.2 hours)carprofen (5 mg/kg) (for 0 hours)coronal plane rotational acceleration of the head (360 krad/s2) (for 0 hours)coronal plane rotational acceleration of the head (250 rad/s2) (for 0 hours)
9amount of experiment time spent in a discrete space in an experimental apparatusSDfemale79.3sisoflurane (4 %) (between 0.1 and 0.2 hours) then carprofen (5 mg/kg) (for 0 hours) then coronal plane rotational acceleration of the head (360 krad/s2) (for 0 hours) and coronal plane rotational acceleration of the head (380 rad/s2) (for 0 hours)98260isoflurane (4 %) (between 0.1 and 0.2 hours)carprofen (5 mg/kg) (for 0 hours)coronal plane rotational acceleration of the head (360 krad/s2) (for 0 hours)coronal plane rotational acceleration of the head (380 rad/s2) (for 0 hours)
9amount of experiment time spent in a discrete space in an experimental apparatusSDfemale51.9sisoflurane (4 %) (between 0.1 and 0.2 hours) then carprofen (5 mg/kg) (for 0 hours) then coronal plane rotational acceleration of the head (500 krad/s2) (for 0 hours) and coronal plane rotational acceleration of the head (615 rad/s2) (for 0 hours)98261isoflurane (4 %) (between 0.1 and 0.2 hours)carprofen (5 mg/kg) (for 0 hours)coronal plane rotational acceleration of the head (500 krad/s2) (for 0 hours)coronal plane rotational acceleration of the head (615 rad/s2) (for 0 hours)
8time to locate a hidden target platform in an experimental apparatusSDfemale24.1sisoflurane (4 %) (between 0.1 and 0.2 hours) then carprofen (5 mg/kg) (for 0 hours)98262isoflurane (4 %) (between 0.1 and 0.2 hours)carprofen (5 mg/kg) (for 0 hours)
8time to locate a hidden target platform in an experimental apparatusSDfemale18.9sisoflurane (4 %) (between 0.1 and 0.2 hours) then carprofen (5 mg/kg) (for 0 hours)98263isoflurane (4 %) (between 0.1 and 0.2 hours)carprofen (5 mg/kg) (for 0 hours)
8time to locate a hidden target platform in an experimental apparatusSDfemale10sisoflurane (4 %) (between 0.1 and 0.2 hours) then carprofen (5 mg/kg) (for 0 hours)98264isoflurane (4 %) (between 0.1 and 0.2 hours)carprofen (5 mg/kg) (for 0 hours)
17time to locate a hidden target platform in an experimental apparatusSDfemale41.7sisoflurane (4 %) (between 0.1 and 0.2 hours) then carprofen (5 mg/kg) (for 0 hours) then coronal plane rotational acceleration of the head (210 krad/s2) (for 0 hours) and coronal plane rotational acceleration of the head (250 rad/s2) (for 0 hours)98265isoflurane (4 %) (between 0.1 and 0.2 hours)carprofen (5 mg/kg) (for 0 hours)coronal plane rotational acceleration of the head (210 krad/s2) (for 0 hours)coronal plane rotational acceleration of the head (250 rad/s2) (for 0 hours)
17time to locate a hidden target platform in an experimental apparatusSDfemale16.7sisoflurane (4 %) (between 0.1 and 0.2 hours) then carprofen (5 mg/kg) (for 0 hours) then coronal plane rotational acceleration of the head (210 krad/s2) (for 0 hours) and coronal plane rotational acceleration of the head (250 rad/s2) (for 0 hours)98266isoflurane (4 %) (between 0.1 and 0.2 hours)carprofen (5 mg/kg) (for 0 hours)coronal plane rotational acceleration of the head (210 krad/s2) (for 0 hours)coronal plane rotational acceleration of the head (250 rad/s2) (for 0 hours)
17time to locate a hidden target platform in an experimental apparatusSDfemale13.6sisoflurane (4 %) (between 0.1 and 0.2 hours) then carprofen (5 mg/kg) (for 0 hours) then coronal plane rotational acceleration of the head (210 krad/s2) (for 0 hours) and coronal plane rotational acceleration of the head (250 rad/s2) (for 0 hours)98267isoflurane (4 %) (between 0.1 and 0.2 hours)carprofen (5 mg/kg) (for 0 hours)coronal plane rotational acceleration of the head (210 krad/s2) (for 0 hours)coronal plane rotational acceleration of the head (250 rad/s2) (for 0 hours)
11time to locate a hidden target platform in an experimental apparatusSDfemale38.5sisoflurane (4 %) (between 0.1 and 0.2 hours) then carprofen (5 mg/kg) (for 0 hours) then coronal plane rotational acceleration of the head (360 krad/s2) (for 0 hours) and coronal plane rotational acceleration of the head (250 rad/s2) (for 0 hours)98268isoflurane (4 %) (between 0.1 and 0.2 hours)carprofen (5 mg/kg) (for 0 hours)coronal plane rotational acceleration of the head (360 krad/s2) (for 0 hours)coronal plane rotational acceleration of the head (250 rad/s2) (for 0 hours)
11time to locate a hidden target platform in an experimental apparatusSDfemale13sisoflurane (4 %) (between 0.1 and 0.2 hours) then carprofen (5 mg/kg) (for 0 hours) then coronal plane rotational acceleration of the head (360 krad/s2) (for 0 hours) and coronal plane rotational acceleration of the head (250 rad/s2) (for 0 hours)98269isoflurane (4 %) (between 0.1 and 0.2 hours)carprofen (5 mg/kg) (for 0 hours)coronal plane rotational acceleration of the head (360 krad/s2) (for 0 hours)coronal plane rotational acceleration of the head (250 rad/s2) (for 0 hours)
11time to locate a hidden target platform in an experimental apparatusSDfemale10.1sisoflurane (4 %) (between 0.1 and 0.2 hours) then carprofen (5 mg/kg) (for 0 hours) then coronal plane rotational acceleration of the head (360 krad/s2) (for 0 hours) and coronal plane rotational acceleration of the head (250 rad/s2) (for 0 hours)98270isoflurane (4 %) (between 0.1 and 0.2 hours)carprofen (5 mg/kg) (for 0 hours)coronal plane rotational acceleration of the head (360 krad/s2) (for 0 hours)coronal plane rotational acceleration of the head (250 rad/s2) (for 0 hours)
9time to locate a hidden target platform in an experimental apparatusSDfemale28sisoflurane (4 %) (between 0.1 and 0.2 hours) then carprofen (5 mg/kg) (for 0 hours) then coronal plane rotational acceleration of the head (360 krad/s2) (for 0 hours) and coronal plane rotational acceleration of the head (380 rad/s2) (for 0 hours)98271isoflurane (4 %) (between 0.1 and 0.2 hours)carprofen (5 mg/kg) (for 0 hours)coronal plane rotational acceleration of the head (360 krad/s2) (for 0 hours)coronal plane rotational acceleration of the head (380 rad/s2) (for 0 hours)
9time to locate a hidden target platform in an experimental apparatusSDfemale20.6sisoflurane (4 %) (between 0.1 and 0.2 hours) then carprofen (5 mg/kg) (for 0 hours) then coronal plane rotational acceleration of the head (360 krad/s2) (for 0 hours) and coronal plane rotational acceleration of the head (380 rad/s2) (for 0 hours)98272isoflurane (4 %) (between 0.1 and 0.2 hours)carprofen (5 mg/kg) (for 0 hours)coronal plane rotational acceleration of the head (360 krad/s2) (for 0 hours)coronal plane rotational acceleration of the head (380 rad/s2) (for 0 hours)
9time to locate a hidden target platform in an experimental apparatusSDfemale17sisoflurane (4 %) (between 0.1 and 0.2 hours) then carprofen (5 mg/kg) (for 0 hours) then coronal plane rotational acceleration of the head (360 krad/s2) (for 0 hours) and coronal plane rotational acceleration of the head (380 rad/s2) (for 0 hours)98273isoflurane (4 %) (between 0.1 and 0.2 hours)carprofen (5 mg/kg) (for 0 hours)coronal plane rotational acceleration of the head (360 krad/s2) (for 0 hours)coronal plane rotational acceleration of the head (380 rad/s2) (for 0 hours)
9time to locate a hidden target platform in an experimental apparatusSDfemale31sisoflurane (4 %) (between 0.1 and 0.2 hours) then carprofen (5 mg/kg) (for 0 hours) then coronal plane rotational acceleration of the head (500 krad/s2) (for 0 hours) and coronal plane rotational acceleration of the head (615 rad/s2) (for 0 hours)98274isoflurane (4 %) (between 0.1 and 0.2 hours)carprofen (5 mg/kg) (for 0 hours)coronal plane rotational acceleration of the head (500 krad/s2) (for 0 hours)coronal plane rotational acceleration of the head (615 rad/s2) (for 0 hours)
9time to locate a hidden target platform in an experimental apparatusSDfemale15.7sisoflurane (4 %) (between 0.1 and 0.2 hours) then carprofen (5 mg/kg) (for 0 hours) then coronal plane rotational acceleration of the head (500 krad/s2) (for 0 hours) and coronal plane rotational acceleration of the head (615 rad/s2) (for 0 hours)98275isoflurane (4 %) (between 0.1 and 0.2 hours)carprofen (5 mg/kg) (for 0 hours)coronal plane rotational acceleration of the head (500 krad/s2) (for 0 hours)coronal plane rotational acceleration of the head (615 rad/s2) (for 0 hours)
9time to locate a hidden target platform in an experimental apparatusSDfemale10.5sisoflurane (4 %) (between 0.1 and 0.2 hours) then carprofen (5 mg/kg) (for 0 hours) then coronal plane rotational acceleration of the head (500 krad/s2) (for 0 hours) and coronal plane rotational acceleration of the head (615 rad/s2) (for 0 hours)98276isoflurane (4 %) (between 0.1 and 0.2 hours)carprofen (5 mg/kg) (for 0 hours)coronal plane rotational acceleration of the head (500 krad/s2) (for 0 hours)coronal plane rotational acceleration of the head (615 rad/s2) (for 0 hours)
6serum testosterone levelSDmale0.4ng/mlin utero condition (for 7 days) and dibutyl phthalate (850 mg/kg/d) (for 7 days)98731in utero condition (for 7 days)dibutyl phthalate (850 mg/kg/d) (for 7 days)
6serum testosterone levelSDmale0.81ng/mlin utero condition (for 7 days) and corn oil (for 7 days)98732in utero condition (for 7 days)corn oil (for 7 days)
43body weightSDmale4.9gin utero condition (for 7 days) and dibutyl phthalate (850 mg/kg/d) (for 7 days)98735in utero condition (for 7 days)dibutyl phthalate (850 mg/kg/d) (for 7 days)
N/Abody weightSDmale6.34gin utero condition (for 7 days) and corn oil (for 7 days)98736in utero condition (for 7 days)corn oil (for 7 days)
43anogenital distance to cube root of body weight ratioSDmale1.48in utero condition (for 7 days) and dibutyl phthalate (850 mg/kg/d) (for 7 days)98737in utero condition (for 7 days)dibutyl phthalate (850 mg/kg/d) (for 7 days)
N/Aanogenital distance to cube root of body weight ratioSDmale1.57in utero condition (for 7 days) and corn oil (for 7 days)98738in utero condition (for 7 days)corn oil (for 7 days)
6body weightSDmale302gartificial aortocaval fistula (for 6 hours)98755artificial aortocaval fistula (for 6 hours)
6body weightSDmale291gsham surgical control condition (for 6 hours)98756sham surgical control condition (for 6 hours)
6body weightSDmale267gartificial aortocaval fistula (for 12 hours)98771artificial aortocaval fistula (for 12 hours)
6body weightSDmale271gsham surgical control condition (for 12 hours)98772sham surgical control condition (for 12 hours)
6body weightSDmale291gartificial aortocaval fistula (for 2 days)98773artificial aortocaval fistula (for 2 days)
6body weightSDmale282gsham surgical control condition (for 2 days)98774sham surgical control condition (for 2 days)
6body weightSDmale281gartificial aortocaval fistula (for 5 days)98775artificial aortocaval fistula (for 5 days)
6body weightSDmale284gsham surgical control condition (between 120 and 12 hours)98776sham surgical control condition (between 120 and 12 hours)
6heart weight to body weight ratioSDmale3.3g/kgartificial aortocaval fistula (for 6 hours)98777artificial aortocaval fistula (for 6 hours)
6heart weight to body weight ratioSDmale3.3g/kgsham surgical control condition (for 6 hours)98778sham surgical control condition (for 6 hours)
6heart weight to body weight ratioSDmale3.5g/kgartificial aortocaval fistula (for 12 hours)98779artificial aortocaval fistula (for 12 hours)
6heart weight to body weight ratioSDmale3.4g/kgsham surgical control condition (for 12 hours)98780sham surgical control condition (for 12 hours)
6heart weight to body weight ratioSDmale3.9g/kgartificial aortocaval fistula (for 2 days)98781artificial aortocaval fistula (for 2 days)
6heart weight to body weight ratioSDmale3.3g/kgsham surgical control condition (for 2 days)98782sham surgical control condition (for 2 days)
6heart weight to body weight ratioSDmale4.2g/kgartificial aortocaval fistula (for 5 days)98783artificial aortocaval fistula (for 5 days)
6heart weight to body weight ratioSDmale3.4g/kgsham surgical control condition (between 120 and 12 hours)98784sham surgical control condition (between 120 and 12 hours)
6heart left ventricle weight to body weight ratioSDmale2.2mg/gartificial aortocaval fistula (for 6 hours)98785artificial aortocaval fistula (for 6 hours)
6heart left ventricle weight to body weight ratioSDmale2.2mg/gsham surgical control condition (for 6 hours)98786sham surgical control condition (for 6 hours)
6heart left ventricle weight to body weight ratioSDmale2.3mg/gartificial aortocaval fistula (for 12 hours)98787artificial aortocaval fistula (for 12 hours)
6heart left ventricle weight to body weight ratioSDmale2.3mg/gsham surgical control condition (for 12 hours)98788sham surgical control condition (for 12 hours)
6heart left ventricle weight to body weight ratioSDmale2.6mg/gartificial aortocaval fistula (for 2 days)98789artificial aortocaval fistula (for 2 days)
6heart left ventricle weight to body weight ratioSDmale2.2mg/gsham surgical control condition (for 2 days)98790sham surgical control condition (for 2 days)
6heart left ventricle weight to body weight ratioSDmale2.7mg/gartificial aortocaval fistula (for 5 days)98791artificial aortocaval fistula (for 5 days)
6heart left ventricle weight to body weight ratioSDmale2.3mg/gsham surgical control condition (between 120 and 12 hours)98792sham surgical control condition (between 120 and 12 hours)
6heart rateSDmale436beats/minartificial aortocaval fistula (for 6 hours) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) 98793artificial aortocaval fistula (for 6 hours)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg)
6heart rateSDmale385beats/minsham surgical control condition (for 6 hours) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) (for 0 hours)98794sham surgical control condition (for 6 hours)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg) (for 0 hours)
6heart rateSDmale419beats/minartificial aortocaval fistula (for 12 hours) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) 98795artificial aortocaval fistula (for 12 hours)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg)
6heart rateSDmale395beats/minsham surgical control condition (for 12 hours) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) (for 0 hours)98796sham surgical control condition (for 12 hours)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg) (for 0 hours)
6heart rateSDmale405beats/minartificial aortocaval fistula (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) 98797artificial aortocaval fistula (for 2 days)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg)
6heart rateSDmale389beats/minsham surgical control condition (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) 98798sham surgical control condition (for 2 days)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg)
6heart rateSDmale395beats/minartificial aortocaval fistula (for 5 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) 98799artificial aortocaval fistula (for 5 days)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg)
6heart rateSDmale365beats/minsham surgical control condition (between 120 and 12 hours) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) (for 0 hours)98800sham surgical control condition (between 120 and 12 hours)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg) (for 0 hours)
6heart rateSDmale420beats/minartificial aortocaval fistula (for 2 days) then vehicle control condition (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) 98801artificial aortocaval fistula (for 2 days)vehicle control condition (for 2 days)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg)
6heart rateSDmale380beats/minsham surgical control condition (for 2 days) then vehicle control condition (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) (for 0 hours)98802sham surgical control condition (for 2 days)vehicle control condition (for 2 days)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg) (for 0 hours)
6heart rateSDmale378beats/minartificial aortocaval fistula (for 2 days) then metoprolol succinate (100 mg/kg/d) (for 2 days) then xylazine (10 mg/kg) and ketamine (80 mg/kg) (for 0 hours)98803artificial aortocaval fistula (for 2 days)metoprolol succinate (100 mg/kg/d) (for 2 days)xylazine (10 mg/kg) ketamine (80 mg/kg) (for 0 hours)
N/Aheart rateSDmale0beats/minartificial aortocaval fistula (for 2 days)98804artificial aortocaval fistula (for 2 days)
6heart rateSDmale365beats/minsham surgical control condition (for 2 days) then metoprolol succinate (100 mg/kg/d) (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) (for 0 hours)98805sham surgical control condition (for 2 days)metoprolol succinate (100 mg/kg/d) (for 2 days)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg) (for 0 hours)
6mean arterial blood pressureSDmale85mmHgartificial aortocaval fistula (for 6 hours) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) 98806artificial aortocaval fistula (for 6 hours)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg)
6mean arterial blood pressureSDmale103mmHgsham surgical control condition (for 6 hours) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) (for 0 hours)98807sham surgical control condition (for 6 hours)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg) (for 0 hours)
6mean arterial blood pressureSDmale70mmHgartificial aortocaval fistula (for 12 hours) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) 98808artificial aortocaval fistula (for 12 hours)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg)
6mean arterial blood pressureSDmale90mmHgsham surgical control condition (for 12 hours) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) (for 0 hours)98809sham surgical control condition (for 12 hours)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg) (for 0 hours)
6mean arterial blood pressureSDmale71mmHgartificial aortocaval fistula (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) 98810artificial aortocaval fistula (for 2 days)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg)
6mean arterial blood pressureSDmale76mmHgsham surgical control condition (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) 98811sham surgical control condition (for 2 days)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg)
6mean arterial blood pressureSDmale74mmHgartificial aortocaval fistula (for 5 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) 98812artificial aortocaval fistula (for 5 days)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg)
6mean arterial blood pressureSDmale85mmHgsham surgical control condition (between 120 and 12 hours) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) (for 0 hours)98813sham surgical control condition (between 120 and 12 hours)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg) (for 0 hours)
6mean arterial blood pressureSDmale72mmHgartificial aortocaval fistula (for 2 days) then vehicle control condition (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) (for 0 hours)98814artificial aortocaval fistula (for 2 days)vehicle control condition (for 2 days)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg) (for 0 hours)
6mean arterial blood pressureSDmale86mmHgsham surgical control condition (for 2 days) then vehicle control condition (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) 98815sham surgical control condition (for 2 days)vehicle control condition (for 2 days)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg)
6mean arterial blood pressureSDmale71mmHgartificial aortocaval fistula (for 2 days) then metoprolol (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) (for 0 hours)98816artificial aortocaval fistula (for 2 days)metoprolol (for 2 days)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg) (for 0 hours)
6mean arterial blood pressureSDmale82mmHgsham surgical control condition (for 2 days) then metoprolol (100 mg/kg/d) (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) 98817sham surgical control condition (for 2 days)metoprolol (100 mg/kg/d) (for 2 days)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg)
6left ventricular end-diastolic blood pressureSDmale7mmHgartificial aortocaval fistula (for 6 hours) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) 98818artificial aortocaval fistula (for 6 hours)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg)
6left ventricular end-diastolic blood pressureSDmale5mmHgsham surgical control condition (for 6 hours) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) (for 0 hours)98819sham surgical control condition (for 6 hours)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg) (for 0 hours)
6left ventricular end-diastolic blood pressureSDmale5mmHgartificial aortocaval fistula (for 12 hours) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) 98820artificial aortocaval fistula (for 12 hours)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg)
6left ventricular end-diastolic blood pressureSDmale2mmHgsham surgical control condition (for 12 hours) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) 98821sham surgical control condition (for 12 hours)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg)
6left ventricular end-diastolic blood pressureSDmale6mmHgartificial aortocaval fistula (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) 98822artificial aortocaval fistula (for 2 days)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg)
6left ventricular end-diastolic blood pressureSDmale2mmHgsham surgical control condition (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) 98823sham surgical control condition (for 2 days)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg)
6left ventricular end-diastolic blood pressureSDmale7mmHgartificial aortocaval fistula (for 5 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) 98824artificial aortocaval fistula (for 5 days)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg)
6left ventricular end-diastolic blood pressureSDmale2mmHgsham surgical control condition (between 120 and 12 hours) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) (for 0 hours)98825sham surgical control condition (between 120 and 12 hours)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg) (for 0 hours)
6left ventricular end-diastolic blood pressureSDmale13mmHgartificial aortocaval fistula (for 2 days) then vehicle control condition (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) (for 0 hours)98826artificial aortocaval fistula (for 2 days)vehicle control condition (for 2 days)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg) (for 0 hours)
6left ventricular end-diastolic blood pressureSDmale3mmHgsham surgical control condition (for 2 days) then vehicle control condition (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) 98827sham surgical control condition (for 2 days)vehicle control condition (for 2 days)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg)
6left ventricular end-diastolic blood pressureSDmale8mmHgartificial aortocaval fistula (for 2 days) then metoprolol (100 mg/kg/d) (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) (for 0 hours)98828artificial aortocaval fistula (for 2 days)metoprolol (100 mg/kg/d) (for 2 days)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg) (for 0 hours)
6left ventricular end-diastolic blood pressureSDmale3mmHgsham surgical control condition (for 2 days) then metoprolol (100 mg/kg/d) (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) 98829sham surgical control condition (for 2 days)metoprolol (100 mg/kg/d) (for 2 days)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg)
6left ventricular end-systolic blood pressureSDmale72mmHgartificial aortocaval fistula (for 6 hours) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) 98830artificial aortocaval fistula (for 6 hours)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg)
6left ventricular end-systolic blood pressureSDmale58mmHgsham surgical control condition (for 6 hours) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) (for 0 hours)98831sham surgical control condition (for 6 hours)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg) (for 0 hours)
6left ventricular end-systolic blood pressureSDmale61mmHgartificial aortocaval fistula (for 12 hours) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) 98832artificial aortocaval fistula (for 12 hours)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg)
6left ventricular end-systolic blood pressureSDmale62mmHgsham surgical control condition (for 12 hours) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) 98833sham surgical control condition (for 12 hours)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg)
6left ventricular end-systolic blood pressureSDmale56mmHgartificial aortocaval fistula (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) 98834artificial aortocaval fistula (for 2 days)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg)
6left ventricular end-systolic blood pressureSDmale66mmHgsham surgical control condition (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) 98835sham surgical control condition (for 2 days)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg)
6left ventricular end-systolic blood pressureSDmale71mmHgartificial aortocaval fistula (for 5 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) 98836artificial aortocaval fistula (for 5 days)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg)
6left ventricular end-systolic blood pressureSDmale58mmHgsham surgical control condition (between 120 and 12 hours) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) (for 0 hours)98837sham surgical control condition (between 120 and 12 hours)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg) (for 0 hours)
6left ventricular end-systolic blood pressureSDmale56mmHgartificial aortocaval fistula (for 2 days) then vehicle control condition (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) (for 0 hours)98838artificial aortocaval fistula (for 2 days)vehicle control condition (for 2 days)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg) (for 0 hours)
6left ventricular end-systolic blood pressureSDmale64mmHgsham surgical control condition (for 2 days) then vehicle control condition (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) 98839sham surgical control condition (for 2 days)vehicle control condition (for 2 days)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg)
6left ventricular end-systolic blood pressureSDmale57mmHgartificial aortocaval fistula (for 2 days) then metoprolol (100 mg/kg/d) (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) (for 0 hours)98840artificial aortocaval fistula (for 2 days)metoprolol (100 mg/kg/d) (for 2 days)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg) (for 0 hours)
6left ventricular end-systolic blood pressureSDmale64mmHgsham surgical control condition (for 2 days) then metoprolol (100 mg/kg/d) (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) 98841sham surgical control condition (for 2 days)metoprolol (100 mg/kg/d) (for 2 days)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg)
6heart left ventricular end-diastolic diameterSDmale7.4mmartificial aortocaval fistula (for 6 hours) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) 98842artificial aortocaval fistula (for 6 hours)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg)
6heart left ventricular end-diastolic diameterSDmale7.2mmsham surgical control condition (for 6 hours) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) (for 0 hours)98843sham surgical control condition (for 6 hours)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg) (for 0 hours)
6heart left ventricular end-diastolic diameterSDmale7.8mmartificial aortocaval fistula (for 12 hours) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) 98844artificial aortocaval fistula (for 12 hours)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg)
6heart left ventricular end-diastolic diameterSDmale7.3mmsham surgical control condition (for 12 hours) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) 98845sham surgical control condition (for 12 hours)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg)
6heart left ventricular end-diastolic diameterSDmale8.1mmartificial aortocaval fistula (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) (for 0 hours)98846artificial aortocaval fistula (for 2 days)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg) (for 0 hours)
6heart left ventricular end-diastolic diameterSDmale7.1mmsham surgical control condition (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) 98847sham surgical control condition (for 2 days)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg)
6heart left ventricular end-diastolic diameterSDmale7.9mmartificial aortocaval fistula (for 5 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) 98848artificial aortocaval fistula (for 5 days)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg)
6heart left ventricular end-diastolic diameterSDmale7.1mmsham surgical control condition (between 120 and 12 hours) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) (for 0 hours)98849sham surgical control condition (between 120 and 12 hours)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg) (for 0 hours)
6heart left ventricle end-systolic diameterSDmale3.8mmartificial aortocaval fistula (for 6 hours) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) 98850artificial aortocaval fistula (for 6 hours)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg)
6heart left ventricle end-systolic diameterSDmale4.2mmsham surgical control condition (for 6 hours) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) (for 0 hours)98851sham surgical control condition (for 6 hours)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg) (for 0 hours)
6heart left ventricle end-systolic diameterSDmale4.1mmartificial aortocaval fistula (for 12 hours) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) 98852artificial aortocaval fistula (for 12 hours)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg)
6heart left ventricle end-systolic diameterSDmale3.8mmsham surgical control condition (for 12 hours) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) 98853sham surgical control condition (for 12 hours)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg)
6heart left ventricle end-systolic diameterSDmale4.1mmartificial aortocaval fistula (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) (for 0 hours)98854artificial aortocaval fistula (for 2 days)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg) (for 0 hours)
6heart left ventricle end-systolic diameterSDmale4mmsham surgical control condition (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) 98855sham surgical control condition (for 2 days)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg)
6heart left ventricle end-systolic diameterSDmale4.1mmartificial aortocaval fistula (for 5 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) 98856artificial aortocaval fistula (for 5 days)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg)
6heart left ventricle end-systolic diameterSDmale3.9mmsham surgical control condition (between 120 and 12 hours) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) (for 0 hours)98857sham surgical control condition (between 120 and 12 hours)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg) (for 0 hours)
6heart left ventricle end-diastolic posterior wall thicknessSDmale1.4mmartificial aortocaval fistula (for 6 hours) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) 98858artificial aortocaval fistula (for 6 hours)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg)
6heart left ventricle end-diastolic posterior wall thicknessSDmale1.6mmsham surgical control condition (for 6 hours) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) (for 0 hours)98859sham surgical control condition (for 6 hours)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg) (for 0 hours)
6heart left ventricle end-diastolic posterior wall thicknessSDmale1.4mmartificial aortocaval fistula (for 12 hours) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) 98860artificial aortocaval fistula (for 12 hours)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg)
6heart left ventricle end-diastolic posterior wall thicknessSDmale1.6mmsham surgical control condition (for 12 hours) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) 98861sham surgical control condition (for 12 hours)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg)
6heart left ventricle end-diastolic posterior wall thicknessSDmale1.3mmartificial aortocaval fistula (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) (for 0 hours)98862artificial aortocaval fistula (for 2 days)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg) (for 0 hours)
6heart left ventricle end-diastolic posterior wall thicknessSDmale1.6mmsham surgical control condition (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) 98863sham surgical control condition (for 2 days)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg)
6heart left ventricle end-diastolic posterior wall thicknessSDmale1.5mmartificial aortocaval fistula (for 5 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) 98864artificial aortocaval fistula (for 5 days)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg)
6heart left ventricle end-diastolic posterior wall thicknessSDmale1.6mmsham surgical control condition (between 120 and 12 hours) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) (for 0 hours)98865sham surgical control condition (between 120 and 12 hours)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg) (for 0 hours)
6heart left ventricle end-diastolic diameter to posterior wall thickness ratioSDmale5.1artificial aortocaval fistula (for 6 hours) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) 98866artificial aortocaval fistula (for 6 hours)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg)
6heart left ventricle end-diastolic diameter to posterior wall thickness ratioSDmale4.4sham surgical control condition (for 6 hours) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) (for 0 hours)98867sham surgical control condition (for 6 hours)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg) (for 0 hours)
6heart left ventricle end-diastolic diameter to posterior wall thickness ratioSDmale5.2artificial aortocaval fistula (for 12 hours) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) 98868artificial aortocaval fistula (for 12 hours)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg)
6heart left ventricle end-diastolic diameter to posterior wall thickness ratioSDmale4.5sham surgical control condition (for 12 hours) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) 98869sham surgical control condition (for 12 hours)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg)
6heart left ventricle end-diastolic diameter to posterior wall thickness ratioSDmale5.9artificial aortocaval fistula (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) (for 0 hours)98870artificial aortocaval fistula (for 2 days)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg) (for 0 hours)
6heart left ventricle end-diastolic diameter to posterior wall thickness ratioSDmale4.6sham surgical control condition (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) 98871sham surgical control condition (for 2 days)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg)
6heart left ventricle end-diastolic diameter to posterior wall thickness ratioSDmale5.3artificial aortocaval fistula (for 5 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) 98872artificial aortocaval fistula (for 5 days)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg)
6heart left ventricle end-diastolic diameter to posterior wall thickness ratioSDmale4.4sham surgical control condition (between 120 and 12 hours) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) (for 0 hours)98873sham surgical control condition (between 120 and 12 hours)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg) (for 0 hours)
6heart left ventricle weight to body weight ratioSDmale2.6mg/gartificial aortocaval fistula (for 2 days) then vehicle control condition (for 2 days)98874artificial aortocaval fistula (for 2 days)vehicle control condition (for 2 days)
6heart left ventricle weight to body weight ratioSDmale2.3mg/gsham surgical control condition (for 2 days) then vehicle control condition (for 2 days)98875sham surgical control condition (for 2 days)vehicle control condition (for 2 days)
6heart left ventricle weight to body weight ratioSDmale2.8mg/gartificial aortocaval fistula (for 2 days) then metoprolol succinate (100 mg/kg/d) (for 2 days)98876artificial aortocaval fistula (for 2 days)metoprolol succinate (100 mg/kg/d) (for 2 days)
6heart left ventricle weight to body weight ratioSDmale2.5mg/gsham surgical control condition (for 2 days) then metoprolol succinate (100 mg/kg/d) (for 2 days)98877sham surgical control condition (for 2 days)metoprolol succinate (100 mg/kg/d) (for 2 days)
6ejection fractionSDmale65%artificial aortocaval fistula (for 6 hours) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) 98878artificial aortocaval fistula (for 6 hours)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg)
6ejection fractionSDmale65%sham surgical control condition (for 6 hours) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) (for 0 hours)98879sham surgical control condition (for 6 hours)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg) (for 0 hours)
6ejection fractionSDmale66%artificial aortocaval fistula (for 12 hours) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) 98880artificial aortocaval fistula (for 12 hours)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg)
6ejection fractionSDmale63%sham surgical control condition (for 12 hours) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) (for 0 hours)98881sham surgical control condition (for 12 hours)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg) (for 0 hours)
6ejection fractionSDmale75%artificial aortocaval fistula (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) 98882artificial aortocaval fistula (for 2 days)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg)
6ejection fractionSDmale65%sham surgical control condition (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) 98883sham surgical control condition (for 2 days)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg)
6ejection fractionSDmale75%artificial aortocaval fistula (for 5 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) 98884artificial aortocaval fistula (for 5 days)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg)
6ejection fractionSDmale64%sham surgical control condition (between 120 and 12 hours) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) (for 0 hours)98885sham surgical control condition (between 120 and 12 hours)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg) (for 0 hours)
6maximum rate of positive change in left ventricular blood pressureSDmale8259mmHg/sartificial aortocaval fistula (for 2 days) then vehicle control condition (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) (for 0 hours)98886artificial aortocaval fistula (for 2 days)vehicle control condition (for 2 days)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg) (for 0 hours)
6maximum rate of positive change in left ventricular blood pressureSDmale8231mmHg/ssham surgical control condition (for 2 days) then vehicle control condition (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) 98887sham surgical control condition (for 2 days)vehicle control condition (for 2 days)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg)
6maximum rate of positive change in left ventricular blood pressureSDmale6971mmHg/sartificial aortocaval fistula (for 2 days) then metoprolol (100 mg/kg/d) (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) (for 0 hours)98888artificial aortocaval fistula (for 2 days)metoprolol (100 mg/kg/d) (for 2 days)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg) (for 0 hours)
6maximum rate of positive change in left ventricular blood pressureSDmale7985mmHg/ssham surgical control condition (for 2 days) then metoprolol (100 mg/kg/d) (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) 98889sham surgical control condition (for 2 days)metoprolol (100 mg/kg/d) (for 2 days)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg)
6maximum rate of negative change in left ventricular blood pressureSDmale-6032mmHg/sartificial aortocaval fistula (for 2 days) then vehicle control condition (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) (for 0 hours)98890artificial aortocaval fistula (for 2 days)vehicle control condition (for 2 days)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg) (for 0 hours)
6maximum rate of negative change in left ventricular blood pressureSDmale-7197mmHg/ssham surgical control condition (for 2 days) then vehicle control condition (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) 98891sham surgical control condition (for 2 days)vehicle control condition (for 2 days)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg)
6maximum rate of negative change in left ventricular blood pressureSDmale-5661mmHg/sartificial aortocaval fistula (for 2 days) then metoprolol (100 mg/kg/d) (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) (for 0 hours)98892artificial aortocaval fistula (for 2 days)metoprolol (100 mg/kg/d) (for 2 days)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg) (for 0 hours)
6maximum rate of negative change in left ventricular blood pressureSDmale-7212mmHg/ssham surgical control condition (for 2 days) then metoprolol succinate (100 mg/kg/d) (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) (for 0 hours)98893sham surgical control condition (for 2 days)metoprolol succinate (100 mg/kg/d) (for 2 days)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg) (for 0 hours)
7body weightSDmale257gleft nephrectomy then puromycin (100 mg/kg) then anti-Shiga toxin 1 beta monoclonal antibody 13C4 (5 mg/kg) then puromycin (40 mg/kg) 98926left nephrectomypuromycin (100 mg/kg) anti-Shiga toxin 1 beta monoclonal antibody 13C4 (5 mg/kg) puromycin (40 mg/kg)
9body weightSDmale258gleft nephrectomy then puromycin (100 mg/kg) then anti-transforming growth factor beta antibody (5 mg/kg) then puromycin (40 mg/kg) 98927left nephrectomypuromycin (100 mg/kg) anti-transforming growth factor beta antibody (5 mg/kg) puromycin (40 mg/kg)
7body weightSDmale256gleft nephrectomy then puromycin (100 mg/kg) then anti-transforming growth factor beta antibody (0.5 mg/kg) then puromycin (40 mg/kg) 98928left nephrectomypuromycin (100 mg/kg) anti-transforming growth factor beta antibody (0.5 mg/kg) puromycin (40 mg/kg)
7body weightSDmale301gleft nephrectomy (for 28 days) then puromycin (100 mg/kg) then anti-Shiga toxin 1 beta monoclonal antibody 13C4 (5 mg/kg) then puromycin (40 mg/kg) 98929left nephrectomy (for 28 days)puromycin (100 mg/kg) anti-Shiga toxin 1 beta monoclonal antibody 13C4 (5 mg/kg) puromycin (40 mg/kg)
9body weightSDmale300gleft nephrectomy (for 28 days) then puromycin (100 mg/kg) then anti-transforming growth factor beta antibody (5 mg/kg) then puromycin (40 mg/kg) 98930left nephrectomy (for 28 days)puromycin (100 mg/kg) anti-transforming growth factor beta antibody (5 mg/kg) puromycin (40 mg/kg)
7body weightSDmale296gleft nephrectomy (for 28 days) then puromycin (100 mg/kg) then anti-transforming growth factor beta antibody (0.5 mg/kg) then puromycin (40 mg/kg) 98931left nephrectomy (for 28 days)puromycin (100 mg/kg) anti-transforming growth factor beta antibody (0.5 mg/kg) puromycin (40 mg/kg)
7body weightSDmale318gleft nephrectomy (for 56 days) then puromycin (100 mg/kg) then anti-Shiga toxin 1 beta monoclonal antibody 13C4 (5 mg/kg) then puromycin (40 mg/kg) 98932left nephrectomy (for 56 days)puromycin (100 mg/kg) anti-Shiga toxin 1 beta monoclonal antibody 13C4 (5 mg/kg) puromycin (40 mg/kg)
9body weightSDmale308gleft nephrectomy (for 56 days) then puromycin (100 mg/kg) then anti-transforming growth factor beta antibody (5 mg/kg) then puromycin (40 mg/kg) 98933left nephrectomy (for 56 days)puromycin (100 mg/kg) anti-transforming growth factor beta antibody (5 mg/kg) puromycin (40 mg/kg)
7body weightSDmale386gleft nephrectomy (for 56 days) then puromycin (100 mg/kg) then anti-transforming growth factor beta antibody (0.5 mg/kg) then puromycin (40 mg/kg) 98934left nephrectomy (for 56 days)puromycin (100 mg/kg) anti-transforming growth factor beta antibody (0.5 mg/kg) puromycin (40 mg/kg)
7body weightSDmale267gleft nephrectomy (for 70 days) then puromycin (100 mg/kg) then anti-Shiga toxin 1 beta monoclonal antibody 13C4 (5 mg/kg) then puromycin (40 mg/kg) 98935left nephrectomy (for 70 days)puromycin (100 mg/kg) anti-Shiga toxin 1 beta monoclonal antibody 13C4 (5 mg/kg) puromycin (40 mg/kg)
9body weightSDmale281gleft nephrectomy (for 70 days) then puromycin (100 mg/kg) then anti-transforming growth factor beta antibody (5 mg/kg) then puromycin (40 mg/kg) 98936left nephrectomy (for 70 days)puromycin (100 mg/kg) anti-transforming growth factor beta antibody (5 mg/kg) puromycin (40 mg/kg)
7body weightSDmale346gleft nephrectomy (for 70 days) then puromycin (100 mg/kg) then anti-transforming growth factor beta antibody (0.5 mg/kg) then puromycin (40 mg/kg) 98937left nephrectomy (for 70 days)puromycin (100 mg/kg) anti-transforming growth factor beta antibody (0.5 mg/kg) puromycin (40 mg/kg)
7mean arterial blood pressureSDmale115mmHgleft nephrectomy then puromycin (100 mg/kg) then anti-Shiga toxin 1 beta monoclonal antibody 13C4 (5 mg/kg) then puromycin (80 mg/kg) 98938left nephrectomypuromycin (100 mg/kg) anti-Shiga toxin 1 beta monoclonal antibody 13C4 (5 mg/kg) puromycin (80 mg/kg)
9mean arterial blood pressureSDmale113mmHgleft nephrectomy then puromycin (100 mg/kg) then anti-transforming growth factor beta antibody (5 mg/kg) then puromycin (80 mg/kg) 98939left nephrectomypuromycin (100 mg/kg) anti-transforming growth factor beta antibody (5 mg/kg) puromycin (80 mg/kg)
7mean arterial blood pressureSDmale111mmHgleft nephrectomy then puromycin (100 mg/kg) then anti-transforming growth factor beta antibody (0.5 mg/kg) then puromycin (80 mg/kg) 98940left nephrectomypuromycin (100 mg/kg) anti-transforming growth factor beta antibody (0.5 mg/kg) puromycin (80 mg/kg)
7mean arterial blood pressureSDmale143mmHgleft nephrectomy (for 28 days) then puromycin (100 mg/kg) then anti-Shiga toxin 1 beta monoclonal antibody 13C4 (5 mg/kg) then puromycin (80 mg/kg) 98941left nephrectomy (for 28 days)puromycin (100 mg/kg) anti-Shiga toxin 1 beta monoclonal antibody 13C4 (5 mg/kg) puromycin (80 mg/kg)
9mean arterial blood pressureSDmale148mmHgleft nephrectomy (for 28 days) then puromycin (100 mg/kg) then anti-transforming growth factor beta antibody (5 mg/kg) then puromycin (80 mg/kg) 98942left nephrectomy (for 28 days)puromycin (100 mg/kg) anti-transforming growth factor beta antibody (5 mg/kg) puromycin (80 mg/kg)
7mean arterial blood pressureSDmale148mmHgleft nephrectomy (for 28 days) then puromycin (100 mg/kg) then anti-transforming growth factor beta antibody (0.5 mg/kg) then puromycin (80 mg/kg) 98943left nephrectomy (for 28 days)puromycin (100 mg/kg) anti-transforming growth factor beta antibody (0.5 mg/kg) puromycin (80 mg/kg)
7mean arterial blood pressureSDmale161mmHgleft nephrectomy (for 56 days) then puromycin (100 mg/kg) then anti-Shiga toxin 1 beta monoclonal antibody 13C4 (5 mg/kg) then puromycin (80 mg/kg) 98944left nephrectomy (for 56 days)puromycin (100 mg/kg) anti-Shiga toxin 1 beta monoclonal antibody 13C4 (5 mg/kg) puromycin (80 mg/kg)
9mean arterial blood pressureSDmale153mmHgleft nephrectomy (for 56 days) then puromycin (100 mg/kg) then anti-transforming growth factor beta antibody (5 mg/kg) then puromycin (80 mg/kg) 98945left nephrectomy (for 56 days)puromycin (100 mg/kg) anti-transforming growth factor beta antibody (5 mg/kg) puromycin (80 mg/kg)
7mean arterial blood pressureSDmale155mmHgleft nephrectomy (for 56 days) then puromycin (100 mg/kg) then anti-transforming growth factor beta antibody (0.5 mg/kg) then puromycin (80 mg/kg) 98946left nephrectomy (for 56 days)puromycin (100 mg/kg) anti-transforming growth factor beta antibody (0.5 mg/kg) puromycin (80 mg/kg)
7mean arterial blood pressureSDmale137mmHgleft nephrectomy (for 70 days) then puromycin (100 mg/kg) then anti-Shiga toxin 1 beta monoclonal antibody 13C4 (5 mg/kg) then puromycin (80 mg/kg) 98947left nephrectomy (for 70 days)puromycin (100 mg/kg) anti-Shiga toxin 1 beta monoclonal antibody 13C4 (5 mg/kg) puromycin (80 mg/kg)
9mean arterial blood pressureSDmale129mmHgleft nephrectomy (for 70 days) then puromycin (100 mg/kg) then anti-transforming growth factor beta antibody (5 mg/kg) then puromycin (80 mg/kg) 98948left nephrectomy (for 70 days)puromycin (100 mg/kg) anti-transforming growth factor beta antibody (5 mg/kg) puromycin (80 mg/kg)
7mean arterial blood pressureSDmale137mmHgleft nephrectomy (for 70 days) then puromycin (100 mg/kg) then anti-transforming growth factor beta antibody (0.5 mg/kg) then puromycin (80 mg/kg) 98949left nephrectomy (for 70 days)puromycin (100 mg/kg) anti-transforming growth factor beta antibody (0.5 mg/kg) puromycin (80 mg/kg)
7urine total protein excretion rateSDmale0.3mg/dleft nephrectomy then puromycin (100 mg/kg) then anti-Shiga toxin 1 beta monoclonal antibody 13C4 (5 mg/kg) then puromycin (80 mg/kg) 98950left nephrectomypuromycin (100 mg/kg) anti-Shiga toxin 1 beta monoclonal antibody 13C4 (5 mg/kg) puromycin (80 mg/kg)
9urine total protein excretion rateSDmale0.7mg/dleft nephrectomy then puromycin (100 mg/kg) then anti-transforming growth factor beta antibody (5 mg/kg) then puromycin (80 mg/kg) 98951left nephrectomypuromycin (100 mg/kg) anti-transforming growth factor beta antibody (5 mg/kg) puromycin (80 mg/kg)
7urine total protein excretion rateSDmale0.9mg/dleft nephrectomy then puromycin (100 mg/kg) then anti-transforming growth factor beta antibody (0.5 mg/kg) then puromycin (80 mg/kg) 98952left nephrectomypuromycin (100 mg/kg) anti-transforming growth factor beta antibody (0.5 mg/kg) puromycin (80 mg/kg)
7urine total protein excretion rateSDmale29.3mg/dleft nephrectomy (for 28 days) then puromycin (100 mg/kg) then anti-Shiga toxin 1 beta monoclonal antibody 13C4 (5 mg/kg) then puromycin (80 mg/kg) 98953left nephrectomy (for 28 days)puromycin (100 mg/kg) anti-Shiga toxin 1 beta monoclonal antibody 13C4 (5 mg/kg) puromycin (80 mg/kg)
9urine total protein excretion rateSDmale24mg/dleft nephrectomy (for 28 days) then puromycin (100 mg/kg) then anti-transforming growth factor beta antibody (5 mg/kg) then puromycin (80 mg/kg) 98954left nephrectomy (for 28 days)puromycin (100 mg/kg) anti-transforming growth factor beta antibody (5 mg/kg) puromycin (80 mg/kg)
7urine total protein excretion rateSDmale30mg/dleft nephrectomy (for 28 days) then puromycin (100 mg/kg) then anti-transforming growth factor beta antibody (0.5 mg/kg) then puromycin (80 mg/kg) 98955left nephrectomy (for 28 days)puromycin (100 mg/kg) anti-transforming growth factor beta antibody (0.5 mg/kg) puromycin (80 mg/kg)
7urine total protein excretion rateSDmale78mg/dleft nephrectomy (for 56 days) then puromycin (100 mg/kg) then anti-Shiga toxin 1 beta monoclonal antibody 13C4 (5 mg/kg) then puromycin (80 mg/kg) 98956left nephrectomy (for 56 days)puromycin (100 mg/kg) anti-Shiga toxin 1 beta monoclonal antibody 13C4 (5 mg/kg) puromycin (80 mg/kg)
9urine total protein excretion rateSDmale74mg/dleft nephrectomy (for 56 days) then puromycin (100 mg/kg) then anti-transforming growth factor beta antibody (5 mg/kg) then puromycin (80 mg/kg) 98957left nephrectomy (for 56 days)puromycin (100 mg/kg) anti-transforming growth factor beta antibody (5 mg/kg) puromycin (80 mg/kg)
7urine total protein excretion rateSDmale97mg/dleft nephrectomy (for 56 days) then puromycin (100 mg/kg) then anti-transforming growth factor beta antibody (0.5 mg/kg) then puromycin (80 mg/kg) 98958left nephrectomy (for 56 days)puromycin (100 mg/kg) anti-transforming growth factor beta antibody (0.5 mg/kg) puromycin (80 mg/kg)
7urine total protein excretion rateSDmale70mg/dleft nephrectomy (for 70 days) then puromycin (100 mg/kg) then anti-Shiga toxin 1 beta monoclonal antibody 13C4 (5 mg/kg) then puromycin (80 mg/kg) 98959left nephrectomy (for 70 days)puromycin (100 mg/kg) anti-Shiga toxin 1 beta monoclonal antibody 13C4 (5 mg/kg) puromycin (80 mg/kg)
9urine total protein excretion rateSDmale78mg/dleft nephrectomy (for 70 days) then puromycin (100 mg/kg) then anti-transforming growth factor beta antibody (5 mg/kg) then puromycin (80 mg/kg) 98960left nephrectomy (for 70 days)puromycin (100 mg/kg) anti-transforming growth factor beta antibody (5 mg/kg) puromycin (80 mg/kg)
7urine total protein excretion rateSDmale127mg/dleft nephrectomy (for 70 days) then puromycin (100 mg/kg) then anti-transforming growth factor beta antibody (0.5 mg/kg) then puromycin (80 mg/kg) 98961left nephrectomy (for 70 days)puromycin (100 mg/kg) anti-transforming growth factor beta antibody (0.5 mg/kg) puromycin (80 mg/kg)
7urine protein level to urine creatinine level ratioSDmale0.06left nephrectomy then puromycin (100 mg/kg) then anti-Shiga toxin 1 beta monoclonal antibody 13C4 (5 mg/kg) then puromycin (80 mg/kg) 98962left nephrectomypuromycin (100 mg/kg) anti-Shiga toxin 1 beta monoclonal antibody 13C4 (5 mg/kg) puromycin (80 mg/kg)
9urine protein level to urine creatinine level ratioSDmale0.1left nephrectomy then puromycin (100 mg/kg) then anti-transforming growth factor beta antibody (5 mg/kg) then puromycin (80 mg/kg) 98963left nephrectomypuromycin (100 mg/kg) anti-transforming growth factor beta antibody (5 mg/kg) puromycin (80 mg/kg)
7urine protein level to urine creatinine level ratioSDmale0.1left nephrectomy then puromycin (100 mg/kg) then anti-transforming growth factor beta antibody (0.5 mg/kg) then puromycin (80 mg/kg) 98964left nephrectomypuromycin (100 mg/kg) anti-transforming growth factor beta antibody (0.5 mg/kg) puromycin (80 mg/kg)
7urine protein level to urine creatinine level ratioSDmale3.5left nephrectomy (for 28 days) then puromycin (100 mg/kg) then anti-Shiga toxin 1 beta monoclonal antibody 13C4 (5 mg/kg) then puromycin (80 mg/kg) 98965left nephrectomy (for 28 days)puromycin (100 mg/kg) anti-Shiga toxin 1 beta monoclonal antibody 13C4 (5 mg/kg) puromycin (80 mg/kg)
9urine protein level to urine creatinine level ratioSDmale3.4left nephrectomy (for 28 days) then puromycin (100 mg/kg) then anti-transforming growth factor beta antibody (5 mg/kg) then puromycin (80 mg/kg) 98966left nephrectomy (for 28 days)puromycin (100 mg/kg) anti-transforming growth factor beta antibody (5 mg/kg) puromycin (80 mg/kg)
7urine protein level to urine creatinine level ratioSDmale4.8left nephrectomy (for 28 days) then puromycin (100 mg/kg) then anti-transforming growth factor beta antibody (0.5 mg/kg) then puromycin (80 mg/kg) 98967left nephrectomy (for 28 days)puromycin (100 mg/kg) anti-transforming growth factor beta antibody (0.5 mg/kg) puromycin (80 mg/kg)
7urine protein level to urine creatinine level ratioSDmale7.6left nephrectomy (for 56 days) then puromycin (100 mg/kg) then anti-Shiga toxin 1 beta monoclonal antibody 13C4 (5 mg/kg) then puromycin (80 mg/kg) 98968left nephrectomy (for 56 days)puromycin (100 mg/kg) anti-Shiga toxin 1 beta monoclonal antibody 13C4 (5 mg/kg) puromycin (80 mg/kg)
9urine protein level to urine creatinine level ratioSDmale6.4left nephrectomy (for 56 days) then puromycin (100 mg/kg) then anti-transforming growth factor beta antibody (5 mg/kg) then puromycin (80 mg/kg) 98969left nephrectomy (for 56 days)puromycin (100 mg/kg) anti-transforming growth factor beta antibody (5 mg/kg) puromycin (80 mg/kg)
7urine protein level to urine creatinine level ratioSDmale7.2left nephrectomy (for 56 days) then puromycin (100 mg/kg) then anti-transforming growth factor beta antibody (0.5 mg/kg) then puromycin (80 mg/kg) 98970left nephrectomy (for 56 days)puromycin (100 mg/kg) anti-transforming growth factor beta antibody (0.5 mg/kg) puromycin (80 mg/kg)
7urine protein level to urine creatinine level ratioSDmale14.4left nephrectomy (for 70 days) then puromycin (100 mg/kg) then anti-Shiga toxin 1 beta monoclonal antibody 13C4 (5 mg/kg) then puromycin (80 mg/kg) 98971left nephrectomy (for 70 days)puromycin (100 mg/kg) anti-Shiga toxin 1 beta monoclonal antibody 13C4 (5 mg/kg) puromycin (80 mg/kg)
9urine protein level to urine creatinine level ratioSDmale13.6left nephrectomy (for 70 days) then puromycin (100 mg/kg) then anti-transforming growth factor beta antibody (5 mg/kg) then puromycin (80 mg/kg) 98972left nephrectomy (for 70 days)puromycin (100 mg/kg) anti-transforming growth factor beta antibody (5 mg/kg) puromycin (80 mg/kg)
7urine protein level to urine creatinine level ratioSDmale13.3left nephrectomy (for 70 days) then puromycin (100 mg/kg) then anti-transforming growth factor beta antibody (0.5 mg/kg) then puromycin (80 mg/kg) 98973left nephrectomy (for 70 days)puromycin (100 mg/kg) anti-transforming growth factor beta antibody (0.5 mg/kg) puromycin (80 mg/kg)
7serum creatinine levelSDmale2.3mg/dlleft nephrectomy (for 70 days) then puromycin (100 mg/kg) then anti-Shiga toxin 1 beta monoclonal antibody 13C4 (5 mg/kg) then puromycin (40 mg/kg) 98991left nephrectomy (for 70 days)puromycin (100 mg/kg) anti-Shiga toxin 1 beta monoclonal antibody 13C4 (5 mg/kg) puromycin (40 mg/kg)
7serum creatinine levelSDmale2.5mg/dlleft nephrectomy (for 70 days) then puromycin (100 mg/kg) then anti-transforming growth factor beta antibody (5 mg/kg) then puromycin (40 mg/kg) 98992left nephrectomy (for 70 days)puromycin (100 mg/kg) anti-transforming growth factor beta antibody (5 mg/kg) puromycin (40 mg/kg)
7serum creatinine levelSDmale0.8mg/dlleft nephrectomy (for 70 days) then puromycin (100 mg/kg) then anti-transforming growth factor beta antibody (0.5 mg/kg) then puromycin (40 mg/kg) 98993left nephrectomy (for 70 days)puromycin (100 mg/kg) anti-transforming growth factor beta antibody (0.5 mg/kg) puromycin (40 mg/kg)
7creatinine clearanceSDmale0.44ml/minleft nephrectomy (for 70 days) then puromycin (100 mg/kg) then anti-Shiga toxin 1 beta monoclonal antibody 13C4 (5 mg/kg) then puromycin (80 mg/kg) 98994left nephrectomy (for 70 days)puromycin (100 mg/kg) anti-Shiga toxin 1 beta monoclonal antibody 13C4 (5 mg/kg) puromycin (80 mg/kg)
7creatinine clearanceSDmale0.7ml/minleft nephrectomy (for 70 days) then puromycin (100 mg/kg) then anti-transforming growth factor beta antibody (5 mg/kg) then puromycin (80 mg/kg) 98995left nephrectomy (for 70 days)puromycin (100 mg/kg) anti-transforming growth factor beta antibody (5 mg/kg) puromycin (80 mg/kg)
7creatinine clearanceSDmale1.34ml/minleft nephrectomy (for 70 days) then puromycin (100 mg/kg) then anti-transforming growth factor beta antibody (0.5 mg/kg) then puromycin (40 mg/kg) 98996left nephrectomy (for 70 days)puromycin (100 mg/kg) anti-transforming growth factor beta antibody (0.5 mg/kg) puromycin (40 mg/kg)
8body weightSDmale359gsham surgical control condition (for 28 days)99191sham surgical control condition (for 28 days)
8body weightSDmale354gartificial aortocaval fistula (for 28 days)99192artificial aortocaval fistula (for 28 days)
10body weightSDmale471gsham surgical control condition (for 105 days)99193sham surgical control condition (for 105 days)
10body weightSDmale489gartificial aortocaval fistula (for 105 days)99194artificial aortocaval fistula (for 105 days)
8heart weightSDmale0.98gsham surgical control condition (for 28 days)99195sham surgical control condition (for 28 days)
8heart weightSDmale1.55gartificial aortocaval fistula (for 28 days)99196artificial aortocaval fistula (for 28 days)
10heart weightSDmale1.26gsham surgical control condition (for 105 days)99197sham surgical control condition (for 105 days)
10heart weightSDmale2.23gartificial aortocaval fistula (for 105 days)99198artificial aortocaval fistula (for 105 days)
8heart weight to body weight ratioSDmale2.7g/kgsham surgical control condition (for 28 days)99199sham surgical control condition (for 28 days)
8heart weight to body weight ratioSDmale4.4g/kgartificial aortocaval fistula (for 28 days)99200artificial aortocaval fistula (for 28 days)
10heart weight to body weight ratioSDmale2.7g/kgsham surgical control condition (for 105 days)99201sham surgical control condition (for 105 days)
10heart weight to body weight ratioSDmale4.8g/kgartificial aortocaval fistula (for 105 days)99202artificial aortocaval fistula (for 105 days)
8heart left ventricle weight to body weight ratioSDmale2.1mg/gsham surgical control condition (for 28 days)99203sham surgical control condition (for 28 days)
8heart left ventricle weight to body weight ratioSDmale3.1mg/gartificial aortocaval fistula (for 28 days)99204artificial aortocaval fistula (for 28 days)
10heart left ventricle weight to body weight ratioSDmale1.9mg/gsham surgical control condition (for 105 days)99205sham surgical control condition (for 105 days)
10heart left ventricle weight to body weight ratioSDmale3.1mg/gartificial aortocaval fistula (for 105 days)99206artificial aortocaval fistula (for 105 days)
8heart right ventricle weight to body weight ratioSDmale0.5mg/gsham surgical control condition (for 28 days)99207sham surgical control condition (for 28 days)
8heart right ventricle weight to body weight ratioSDmale0.9mg/gartificial aortocaval fistula (for 28 days)99208artificial aortocaval fistula (for 28 days)
10heart right ventricle weight to body weight ratioSDmale0.5mg/gsham surgical control condition (for 105 days)99209sham surgical control condition (for 105 days)
10heart right ventricle weight to body weight ratioSDmale1mg/gartificial aortocaval fistula (for 105 days)99210artificial aortocaval fistula (for 105 days)
8lung weightSDmale1.46gsham surgical control condition (for 28 days)99211sham surgical control condition (for 28 days)
8lung weightSDmale1.84gartificial aortocaval fistula (for 28 days)99212artificial aortocaval fistula (for 28 days)
10lung weightSDmale1.97gsham surgical control condition (for 105 days)99213sham surgical control condition (for 105 days)
10lung weightSDmale2.44gartificial aortocaval fistula (for 105 days)99214artificial aortocaval fistula (for 105 days)
8heart rateSDmale260beats/minsham surgical control condition (for 28 days)99215sham surgical control condition (for 28 days)
8heart rateSDmale271beats/minartificial aortocaval fistula (for 28 days)99216artificial aortocaval fistula (for 28 days)
10heart rateSDmale217beats/minsham surgical control condition (for 105 days)99217sham surgical control condition (for 105 days)
10heart rateSDmale220beats/minartificial aortocaval fistula (for 105 days)99218artificial aortocaval fistula (for 105 days)
8mean arterial blood pressureSDmale114mmHgsham surgical control condition (for 28 days)99219sham surgical control condition (for 28 days)
8mean arterial blood pressureSDmale95mmHgartificial aortocaval fistula (for 28 days)99220artificial aortocaval fistula (for 28 days)
10mean arterial blood pressureSDmale95mmHgsham surgical control condition (for 105 days)99221sham surgical control condition (for 105 days)
10mean arterial blood pressureSDmale82mmHgartificial aortocaval fistula (for 105 days)99222artificial aortocaval fistula (for 105 days)
8left ventricular end-diastolic blood pressureSDmale2mmHgsham surgical control condition (for 28 days)99223sham surgical control condition (for 28 days)
8left ventricular end-diastolic blood pressureSDmale7mmHgartificial aortocaval fistula (for 28 days)99224artificial aortocaval fistula (for 28 days)
10left ventricular end-diastolic blood pressureSDmale5mmHgsham surgical control condition (for 105 days)99225sham surgical control condition (for 105 days)
10left ventricular end-diastolic blood pressureSDmale9mmHgartificial aortocaval fistula (for 105 days)99226artificial aortocaval fistula (for 105 days)
8maximum rate of positive change in left ventricular blood pressureSDmale8031mmHg/ssham surgical control condition (for 28 days)99227sham surgical control condition (for 28 days)
8maximum rate of positive change in left ventricular blood pressureSDmale8947mmHg/sartificial aortocaval fistula (for 28 days)99228artificial aortocaval fistula (for 28 days)
10maximum rate of positive change in left ventricular blood pressureSDmale7529mmHg/ssham surgical control condition (for 105 days)99229sham surgical control condition (for 105 days)
10maximum rate of positive change in left ventricular blood pressureSDmale6600mmHg/sartificial aortocaval fistula (for 105 days)99230artificial aortocaval fistula (for 105 days)
8maximum rate of negative change in left ventricular blood pressureSDmale-7479mmHg/ssham surgical control condition (for 28 days)99231sham surgical control condition (for 28 days)
8maximum rate of negative change in left ventricular blood pressureSDmale-6995mmHg/sartificial aortocaval fistula (for 28 days)99232artificial aortocaval fistula (for 28 days)
10maximum rate of negative change in left ventricular blood pressureSDmale-5401mmHg/ssham surgical control condition (for 105 days)99233sham surgical control condition (for 105 days)
10maximum rate of negative change in left ventricular blood pressureSDmale-4244mmHg/sartificial aortocaval fistula (for 105 days)99234artificial aortocaval fistula (for 105 days)
8heart left ventricular end-diastolic diameterSDmale7mmsham surgical control condition (for 28 days)99235sham surgical control condition (for 28 days)
8heart left ventricular end-diastolic diameterSDmale10.1mmartificial aortocaval fistula (for 28 days)99236artificial aortocaval fistula (for 28 days)
10heart left ventricular end-diastolic diameterSDmale9mmsham surgical control condition (for 105 days)99237sham surgical control condition (for 105 days)
10heart left ventricular end-diastolic diameterSDmale11.6mmartificial aortocaval fistula (for 105 days)99238artificial aortocaval fistula (for 105 days)
8heart left ventricle end-systolic diameterSDmale4.3mmsham surgical control condition (for 28 days)99239sham surgical control condition (for 28 days)
8heart left ventricle end-systolic diameterSDmale6.3mmartificial aortocaval fistula (for 28 days)99240artificial aortocaval fistula (for 28 days)
10heart left ventricle end-systolic diameterSDmale5.6mmsham surgical control condition (for 105 days)99241sham surgical control condition (for 105 days)
10heart left ventricle end-systolic diameterSDmale7.4mmartificial aortocaval fistula (for 105 days)99242artificial aortocaval fistula (for 105 days)
8heart left ventricle end-diastolic diameter to posterior wall thickness ratioSDmale4.8sham surgical control condition (for 28 days)99243sham surgical control condition (for 28 days)
8heart left ventricle end-diastolic diameter to posterior wall thickness ratioSDmale7.7artificial aortocaval fistula (for 28 days)99244artificial aortocaval fistula (for 28 days)
10heart left ventricle end-diastolic diameter to posterior wall thickness ratioSDmale5.9sham surgical control condition (for 105 days)99245sham surgical control condition (for 105 days)
10heart left ventricle end-diastolic diameter to posterior wall thickness ratioSDmale7.9artificial aortocaval fistula (for 105 days)99246artificial aortocaval fistula (for 105 days)
8left ventricle end-diastolic wall stressSDmale3g/cm2sham surgical control condition (for 28 days)99247sham surgical control condition (for 28 days)
8left ventricle end-diastolic wall stressSDmale14g/cm2artificial aortocaval fistula (for 28 days)99248artificial aortocaval fistula (for 28 days)
10left ventricle end-diastolic wall stressSDmale7g/cm2sham surgical control condition (for 105 days)99249sham surgical control condition (for 105 days)
10left ventricle end-diastolic wall stressSDmale16g/cm2artificial aortocaval fistula (for 105 days)99250artificial aortocaval fistula (for 105 days)
8left ventricle end-systolic wall stressSDmale67g/cm2sham surgical control condition (for 28 days)99251sham surgical control condition (for 28 days)
8left ventricle end-systolic wall stressSDmale77g/cm2artificial aortocaval fistula (for 28 days)99252artificial aortocaval fistula (for 28 days)
10left ventricle end-systolic wall stressSDmale72g/cm2sham surgical control condition (for 105 days)99253sham surgical control condition (for 105 days)
10left ventricle end-systolic wall stressSDmale80g/cm2artificial aortocaval fistula (for 105 days)99254artificial aortocaval fistula (for 105 days)
8heart left ventricle fractional shorteningSDmale38%sham surgical control condition (for 28 days)99255sham surgical control condition (for 28 days)
8heart left ventricle fractional shorteningSDmale38%artificial aortocaval fistula (for 28 days)99256artificial aortocaval fistula (for 28 days)
10heart left ventricle fractional shorteningSDmale40%sham surgical control condition (for 105 days)99257sham surgical control condition (for 105 days)
10heart left ventricle fractional shorteningSDmale34%artificial aortocaval fistula (for 105 days)99258artificial aortocaval fistula (for 105 days)
8heart left ventricle interstitial angiotensin II level during a period of timeSDmale1.5pg/hrsham surgical control condition (for 28 days)99259sham surgical control condition (for 28 days)
9heart left ventricle interstitial angiotensin II level during a period of timeSDmale3pg/hrartificial aortocaval fistula (for 28 days)99260artificial aortocaval fistula (for 28 days)
8heart left ventricle interstitial angiotensin II level during a period of timeSDmale1.6pg/hrsham surgical control condition (for 105 days)99261sham surgical control condition (for 105 days)
10heart left ventricle interstitial angiotensin II level during a period of timeSDmale1.9pg/hrartificial aortocaval fistula (for 105 days)99262artificial aortocaval fistula (for 105 days)
8heart left ventricle interstitial bradykinin level during a period of timeSDmale6.4pg/hrsham surgical control condition (for 28 days)99263sham surgical control condition (for 28 days)
9heart left ventricle interstitial bradykinin level during a period of timeSDmale9.3pg/hrartificial aortocaval fistula (for 28 days)99264artificial aortocaval fistula (for 28 days)
8heart left ventricle interstitial bradykinin level during a period of timeSDmale7.4pg/hrsham surgical control condition (for 105 days)99265sham surgical control condition (for 105 days)
10heart left ventricle interstitial bradykinin level during a period of timeSDmale12.4pg/hrartificial aortocaval fistula (for 105 days)99266artificial aortocaval fistula (for 105 days)
8heart left ventricle interstitial norepinephrine level during a period of timeSDmale6.2pg/hrsham surgical control condition (for 28 days)99267sham surgical control condition (for 28 days)
9heart left ventricle interstitial norepinephrine level during a period of timeSDmale6.8pg/hrartificial aortocaval fistula (for 28 days)99268artificial aortocaval fistula (for 28 days)
8heart left ventricle interstitial norepinephrine level during a period of timeSDmale5.9pg/hrsham surgical control condition (for 105 days)99269sham surgical control condition (for 105 days)
10heart left ventricle interstitial norepinephrine level during a period of timeSDmale10.2pg/hrartificial aortocaval fistula (for 105 days)99270artificial aortocaval fistula (for 105 days)
8heart left ventricle interstitial epinephrine level during a period of timeSDmale3.5pg/hrsham surgical control condition (for 28 days)99271sham surgical control condition (for 28 days)
9heart left ventricle interstitial epinephrine level during a period of timeSDmale5.3pg/hrartificial aortocaval fistula (for 28 days)99272artificial aortocaval fistula (for 28 days)
8heart left ventricle interstitial epinephrine level during a period of timeSDmale3.5pg/hrsham surgical control condition (for 105 days)99273sham surgical control condition (for 105 days)
10heart left ventricle interstitial epinephrine level during a period of timeSDmale8.6pg/hrartificial aortocaval fistula (for 105 days)99274artificial aortocaval fistula (for 105 days)
8plasma angiotensin II levelSDmale29pg/mlsham surgical control condition (for 28 days)99275sham surgical control condition (for 28 days)
9plasma angiotensin II levelSDmale107pg/mlartificial aortocaval fistula (for 28 days)99276artificial aortocaval fistula (for 28 days)
8plasma angiotensin II levelSDmale34pg/mlsham surgical control condition (for 105 days)99277sham surgical control condition (for 105 days)
10plasma angiotensin II levelSDmale65pg/mlartificial aortocaval fistula (for 105 days)99278artificial aortocaval fistula (for 105 days)
8plasma bradykinin levelSDmale10pg/mlsham surgical control condition (for 28 days)99279sham surgical control condition (for 28 days)
9plasma bradykinin levelSDmale28pg/mlartificial aortocaval fistula (for 28 days)99280artificial aortocaval fistula (for 28 days)
8plasma bradykinin levelSDmale17pg/mlsham surgical control condition (for 105 days)99281sham surgical control condition (for 105 days)
10plasma bradykinin levelSDmale29pg/mlartificial aortocaval fistula (for 105 days)99282artificial aortocaval fistula (for 105 days)
8plasma norepinephrine levelSDmale93pg/mlsham surgical control condition (for 28 days)99283sham surgical control condition (for 28 days)
9plasma norepinephrine levelSDmale89pg/mlartificial aortocaval fistula (for 28 days)99284artificial aortocaval fistula (for 28 days)
8plasma norepinephrine levelSDmale102pg/mlsham surgical control condition (for 105 days)99285sham surgical control condition (for 105 days)
10plasma norepinephrine levelSDmale159pg/mlartificial aortocaval fistula (for 105 days)99286artificial aortocaval fistula (for 105 days)
8plasma epinephrine levelSDmale83pg/mlsham surgical control condition (for 28 days)99287sham surgical control condition (for 28 days)
9plasma epinephrine levelSDmale91pg/mlartificial aortocaval fistula (for 28 days)99288artificial aortocaval fistula (for 28 days)
8plasma epinephrine levelSDmale75pg/mlsham surgical control condition (for 105 days)99289sham surgical control condition (for 105 days)
10plasma epinephrine levelSDmale101pg/mlartificial aortocaval fistula (for 105 days)99290artificial aortocaval fistula (for 105 days)
5heart rateSDmale359beats/minsham surgical control condition (for 2 days)99291sham surgical control condition (for 2 days)
5heart rateSDmale367beats/minartificial aortocaval fistula (for 2 days)99292artificial aortocaval fistula (for 2 days)
5heart rateSDmale371beats/minsham surgical control condition (for 2 days) then Aprotinin (12000 kIU) (for 2 days)99293sham surgical control condition (for 2 days)Aprotinin (12000 kIU) (for 2 days)
5heart rateSDmale375beats/minartificial aortocaval fistula (for 2 days) then Aprotinin (12000 kIU) (for 2 days)99294artificial aortocaval fistula (for 2 days)Aprotinin (12000 kIU) (for 2 days)
7heart rateSDmale321beats/minsham surgical control condition (for 28 days)99295sham surgical control condition (for 28 days)
8heart rateSDmale307beats/minartificial aortocaval fistula (for 28 days)99296artificial aortocaval fistula (for 28 days)
7heart rateSDmale312beats/minsham surgical control condition (for 28 days) then Aprotinin (12000 kIU) (for 28 days)99297sham surgical control condition (for 28 days)Aprotinin (12000 kIU) (for 28 days)
8heart rateSDmale316beats/minartificial aortocaval fistula (for 28 days) then Aprotinin (12000 kIU) (for 28 days)99298artificial aortocaval fistula (for 28 days)Aprotinin (12000 kIU) (for 28 days)
5mean arterial blood pressureSDmale100mmHgsham surgical control condition (for 2 days)99299sham surgical control condition (for 2 days)
5mean arterial blood pressureSDmale89mmHgartificial aortocaval fistula (for 2 days)99300artificial aortocaval fistula (for 2 days)
5mean arterial blood pressureSDmale106mmHgsham surgical control condition (for 2 days) then Aprotinin (12000 kIU) (for 2 days)99301sham surgical control condition (for 2 days)Aprotinin (12000 kIU) (for 2 days)
5mean arterial blood pressureSDmale84mmHgartificial aortocaval fistula (for 2 days) then Aprotinin (12000 kIU) (for 2 days)99302artificial aortocaval fistula (for 2 days)Aprotinin (12000 kIU) (for 2 days)
7mean arterial blood pressureSDmale107mmHgsham surgical control condition (for 28 days)99303sham surgical control condition (for 28 days)
8mean arterial blood pressureSDmale90mmHgartificial aortocaval fistula (for 28 days)99304artificial aortocaval fistula (for 28 days)
7mean arterial blood pressureSDmale106mmHgsham surgical control condition (for 28 days) then Aprotinin (12000 kIU) (for 28 days)99305sham surgical control condition (for 28 days)Aprotinin (12000 kIU) (for 28 days)
8mean arterial blood pressureSDmale86mmHgartificial aortocaval fistula (for 28 days) then Aprotinin (12000 kIU) (for 28 days)99306artificial aortocaval fistula (for 28 days)Aprotinin (12000 kIU) (for 28 days)
5left ventricular end-diastolic blood pressureSDmale6mmHgsham surgical control condition (for 2 days)99307sham surgical control condition (for 2 days)
5left ventricular end-diastolic blood pressureSDmale11mmHgartificial aortocaval fistula (for 2 days)99308artificial aortocaval fistula (for 2 days)
5left ventricular end-diastolic blood pressureSDmale5mmHgsham surgical control condition (for 2 days) then Aprotinin (12000 kIU) (for 2 days)99309sham surgical control condition (for 2 days)Aprotinin (12000 kIU) (for 2 days)
5left ventricular end-diastolic blood pressureSDmale11mmHgartificial aortocaval fistula (for 2 days) then Aprotinin (12000 kIU) (for 2 days)99310artificial aortocaval fistula (for 2 days)Aprotinin (12000 kIU) (for 2 days)
7left ventricular end-diastolic blood pressureSDmale4.2mmHgsham surgical control condition (for 28 days)99311sham surgical control condition (for 28 days)
8left ventricular end-diastolic blood pressureSDmale10mmHgartificial aortocaval fistula (for 28 days)99312artificial aortocaval fistula (for 28 days)
7left ventricular end-diastolic blood pressureSDmale4mmHgsham surgical control condition (for 28 days) then Aprotinin (12000 kIU) (for 28 days)99313sham surgical control condition (for 28 days)Aprotinin (12000 kIU) (for 28 days)
8left ventricular end-diastolic blood pressureSDmale10mmHgartificial aortocaval fistula (for 28 days) then Aprotinin (12000 kIU) (for 28 days)99314artificial aortocaval fistula (for 28 days)Aprotinin (12000 kIU) (for 28 days)
5left ventricular end-systolic blood pressureSDmale55mmHgsham surgical control condition (for 2 days)99315sham surgical control condition (for 2 days)
5left ventricular end-systolic blood pressureSDmale61mmHgartificial aortocaval fistula (for 2 days)99316artificial aortocaval fistula (for 2 days)
5left ventricular end-systolic blood pressureSDmale58mmHgsham surgical control condition (for 2 days) then Aprotinin (12000 kIU) (for 2 days)99317sham surgical control condition (for 2 days)Aprotinin (12000 kIU) (for 2 days)
5left ventricular end-systolic blood pressureSDmale57mmHgartificial aortocaval fistula (for 2 days) then Aprotinin (12000 kIU) (for 2 days)99318artificial aortocaval fistula (for 2 days)Aprotinin (12000 kIU) (for 2 days)
7left ventricular end-systolic blood pressureSDmale85mmHgsham surgical control condition (for 28 days)99319sham surgical control condition (for 28 days)
8left ventricular end-systolic blood pressureSDmale75mmHgartificial aortocaval fistula (for 28 days)99320artificial aortocaval fistula (for 28 days)
7left ventricular end-systolic blood pressureSDmale86mmHgsham surgical control condition (for 28 days) then Aprotinin (12000 kIU) (for 28 days)99321sham surgical control condition (for 28 days)Aprotinin (12000 kIU) (for 28 days)
8left ventricular end-systolic blood pressureSDmale70mmHgartificial aortocaval fistula (for 28 days) then Aprotinin (12000 kIU) (for 28 days)99322artificial aortocaval fistula (for 28 days)Aprotinin (12000 kIU) (for 28 days)
5maximum rate of positive change in left ventricular blood pressureSDmale8767mmHg/ssham surgical control condition (for 2 days)99323sham surgical control condition (for 2 days)
5maximum rate of positive change in left ventricular blood pressureSDmale9386mmHg/sartificial aortocaval fistula (for 2 days)99324artificial aortocaval fistula (for 2 days)
5maximum rate of positive change in left ventricular blood pressureSDmale8301mmHg/ssham surgical control condition (for 2 days) then Aprotinin (12000 kIU) (for 2 days)99325sham surgical control condition (for 2 days)Aprotinin (12000 kIU) (for 2 days)
5maximum rate of positive change in left ventricular blood pressureSDmale9065mmHg/sartificial aortocaval fistula (for 2 days) then Aprotinin (12000 kIU) (for 2 days)99326artificial aortocaval fistula (for 2 days)Aprotinin (12000 kIU) (for 2 days)
7maximum rate of positive change in left ventricular blood pressureSDmale8505mmHg/ssham surgical control condition (for 28 days)99327sham surgical control condition (for 28 days)
8maximum rate of positive change in left ventricular blood pressureSDmale8116mmHg/sartificial aortocaval fistula (for 28 days)99328artificial aortocaval fistula (for 28 days)
7maximum rate of positive change in left ventricular blood pressureSDmale7931mmHg/ssham surgical control condition (for 28 days) then Aprotinin (12000 kIU) (for 28 days)99329sham surgical control condition (for 28 days)Aprotinin (12000 kIU) (for 28 days)
8maximum rate of positive change in left ventricular blood pressureSDmale8937mmHg/sartificial aortocaval fistula (for 28 days) then Aprotinin (12000 kIU) (for 28 days)99330artificial aortocaval fistula (for 28 days)Aprotinin (12000 kIU) (for 28 days)
5maximum rate of negative change in left ventricular blood pressureSDmale-7474mmHg/ssham surgical control condition (for 2 days)99331sham surgical control condition (for 2 days)
5maximum rate of negative change in left ventricular blood pressureSDmale-8797mmHg/sartificial aortocaval fistula (for 2 days)99332artificial aortocaval fistula (for 2 days)
5maximum rate of negative change in left ventricular blood pressureSDmale-8474mmHg/ssham surgical control condition (for 2 days) then Aprotinin (12000 kIU) (for 2 days)99333sham surgical control condition (for 2 days)Aprotinin (12000 kIU) (for 2 days)
5maximum rate of negative change in left ventricular blood pressureSDmale-7879mmHg/sartificial aortocaval fistula (for 2 days) then Aprotinin (12000 kIU) (for 2 days)99334artificial aortocaval fistula (for 2 days)Aprotinin (12000 kIU) (for 2 days)
7maximum rate of negative change in left ventricular blood pressureSDmale-7379mmHg/ssham surgical control condition (for 28 days)99335sham surgical control condition (for 28 days)
7maximum rate of negative change in left ventricular blood pressureSDmale-7422mmHg/ssham surgical control condition (for 28 days) then Aprotinin (12000 kIU) (for 28 days)99336sham surgical control condition (for 28 days)Aprotinin (12000 kIU) (for 28 days)
8maximum rate of negative change in left ventricular blood pressureSDmale-6834mmHg/sartificial aortocaval fistula (for 28 days) then Aprotinin (12000 kIU) (for 28 days)99337artificial aortocaval fistula (for 28 days)Aprotinin (12000 kIU) (for 28 days)
8maximum rate of negative change in left ventricular blood pressureSDmale-5948mmHg/sartificial aortocaval fistula (for 28 days)99338artificial aortocaval fistula (for 28 days)
5heart left ventricular end-diastolic diameterSDmale6.9mmsham surgical control condition (for 2 days)99339sham surgical control condition (for 2 days)
5heart left ventricular end-diastolic diameterSDmale8.2mmartificial aortocaval fistula (for 2 days)99340artificial aortocaval fistula (for 2 days)
5heart left ventricular end-diastolic diameterSDmale7mmsham surgical control condition (for 2 days) then Aprotinin (12000 kIU) (for 2 days)99341sham surgical control condition (for 2 days)Aprotinin (12000 kIU) (for 2 days)
5heart left ventricular end-diastolic diameterSDmale8mmartificial aortocaval fistula (for 2 days) then Aprotinin (12000 kIU) (for 2 days)99342artificial aortocaval fistula (for 2 days)Aprotinin (12000 kIU) (for 2 days)
7heart left ventricular end-diastolic diameterSDmale7.7mmsham surgical control condition (for 28 days)99343sham surgical control condition (for 28 days)
8heart left ventricular end-diastolic diameterSDmale10.6mmartificial aortocaval fistula (for 28 days)99344artificial aortocaval fistula (for 28 days)
7heart left ventricular end-diastolic diameterSDmale7.6mmsham surgical control condition (for 28 days) then Aprotinin (12000 kIU) (for 28 days)99345sham surgical control condition (for 28 days)Aprotinin (12000 kIU) (for 28 days)
8heart left ventricular end-diastolic diameterSDmale10.2mmartificial aortocaval fistula (for 28 days) then Aprotinin (12000 kIU) (for 28 days)99346artificial aortocaval fistula (for 28 days)Aprotinin (12000 kIU) (for 28 days)
5heart left ventricle end-systolic diameterSDmale4mmsham surgical control condition (for 2 days)99347sham surgical control condition (for 2 days)
5heart left ventricle end-systolic diameterSDmale4.3mmartificial aortocaval fistula (for 2 days)99348artificial aortocaval fistula (for 2 days)
5heart left ventricle end-systolic diameterSDmale4.1mmsham surgical control condition (for 2 days) then Aprotinin (12000 kIU) (for 2 days)99349sham surgical control condition (for 2 days)Aprotinin (12000 kIU) (for 2 days)
5heart left ventricle end-systolic diameterSDmale4mmartificial aortocaval fistula (for 2 days) then Aprotinin (12000 kIU) (for 2 days)99350artificial aortocaval fistula (for 2 days)Aprotinin (12000 kIU) (for 2 days)
7heart left ventricle end-systolic diameterSDmale4.7mmsham surgical control condition (for 28 days)99351sham surgical control condition (for 28 days)
8heart left ventricle end-systolic diameterSDmale6.8mmartificial aortocaval fistula (for 28 days)99352artificial aortocaval fistula (for 28 days)
7heart left ventricle end-systolic diameterSDmale4.7mmsham surgical control condition (for 28 days) then Aprotinin (12000 kIU) (for 28 days)99353sham surgical control condition (for 28 days)Aprotinin (12000 kIU) (for 28 days)
8heart left ventricle end-systolic diameterSDmale5.9mmartificial aortocaval fistula (for 28 days) then Aprotinin (12000 kIU) (for 28 days)99354artificial aortocaval fistula (for 28 days)Aprotinin (12000 kIU) (for 28 days)
5heart left ventricle end-diastolic diameter to posterior wall thickness ratioSDmale4.6sham surgical control condition (for 2 days)99355sham surgical control condition (for 2 days)
5heart left ventricle end-diastolic diameter to posterior wall thickness ratioSDmale5.8artificial aortocaval fistula (for 2 days)99356artificial aortocaval fistula (for 2 days)
5heart left ventricle end-diastolic diameter to posterior wall thickness ratioSDmale4.6sham surgical control condition (for 2 days) then Aprotinin (12000 kIU) (for 2 days)99357sham surgical control condition (for 2 days)Aprotinin (12000 kIU) (for 2 days)
5heart left ventricle end-diastolic diameter to posterior wall thickness ratioSDmale5.4artificial aortocaval fistula (for 2 days) then Aprotinin (12000 kIU) (for 2 days)99358artificial aortocaval fistula (for 2 days)Aprotinin (12000 kIU) (for 2 days)
7heart left ventricle end-diastolic diameter to posterior wall thickness ratioSDmale4.2sham surgical control condition (for 28 days)99359sham surgical control condition (for 28 days)
8heart left ventricle end-diastolic diameter to posterior wall thickness ratioSDmale5.7artificial aortocaval fistula (for 28 days)99360artificial aortocaval fistula (for 28 days)
7heart left ventricle end-diastolic diameter to posterior wall thickness ratioSDmale4.5sham surgical control condition (for 28 days) then Aprotinin (12000 kIU) (for 28 days)99361sham surgical control condition (for 28 days)Aprotinin (12000 kIU) (for 28 days)
8heart left ventricle end-diastolic diameter to posterior wall thickness ratioSDmale6artificial aortocaval fistula (for 28 days) then Aprotinin (12000 kIU) (for 28 days)99362artificial aortocaval fistula (for 28 days)Aprotinin (12000 kIU) (for 28 days)
5heart left ventricle fractional shorteningSDmale41%sham surgical control condition (for 2 days)99363sham surgical control condition (for 2 days)
5heart left ventricle fractional shorteningSDmale48%artificial aortocaval fistula (for 2 days)99364artificial aortocaval fistula (for 2 days)
5heart left ventricle fractional shorteningSDmale43%sham surgical control condition (for 2 days) then Aprotinin (12000 kIU) (for 2 days)99365sham surgical control condition (for 2 days)Aprotinin (12000 kIU) (for 2 days)
5heart left ventricle fractional shorteningSDmale50%artificial aortocaval fistula (for 2 days) then Aprotinin (12000 kIU) (for 2 days)99366artificial aortocaval fistula (for 2 days)Aprotinin (12000 kIU) (for 2 days)
7heart left ventricle fractional shorteningSDmale38%sham surgical control condition (for 28 days)99367sham surgical control condition (for 28 days)
8heart left ventricle fractional shorteningSDmale37%artificial aortocaval fistula (for 28 days)99368artificial aortocaval fistula (for 28 days)
8heart left ventricle fractional shorteningSDmale39%artificial aortocaval fistula (for 28 days) then Aprotinin (12000 kIU) (for 28 days)99369artificial aortocaval fistula (for 28 days)Aprotinin (12000 kIU) (for 28 days)
8heart left ventricle fractional shorteningSDmale43%artificial aortocaval fistula (for 28 days) then Aprotinin (12000 kIU) (for 28 days)99370artificial aortocaval fistula (for 28 days)Aprotinin (12000 kIU) (for 28 days)
5ejection fractionSDmale66%sham surgical control condition (for 2 days)99371sham surgical control condition (for 2 days)
5ejection fractionSDmale76%artificial aortocaval fistula (for 2 days)99372artificial aortocaval fistula (for 2 days)
5ejection fractionSDmale72%sham surgical control condition (for 2 days) then Aprotinin (12000 kIU) (for 2 days)99373sham surgical control condition (for 2 days)Aprotinin (12000 kIU) (for 2 days)
5ejection fractionSDmale79%artificial aortocaval fistula (for 2 days) then Aprotinin (12000 kIU) (for 2 days)99374artificial aortocaval fistula (for 2 days)Aprotinin (12000 kIU) (for 2 days)
7ejection fractionSDmale66%sham surgical control condition (for 28 days)99375sham surgical control condition (for 28 days)
8ejection fractionSDmale63%artificial aortocaval fistula (for 28 days)99376artificial aortocaval fistula (for 28 days)
7ejection fractionSDmale67%sham surgical control condition (for 28 days) then Aprotinin (12000 kIU) (for 28 days)99377sham surgical control condition (for 28 days)Aprotinin (12000 kIU) (for 28 days)
8ejection fractionSDmale71%artificial aortocaval fistula (for 28 days) then Aprotinin (12000 kIU) (for 28 days)99378artificial aortocaval fistula (for 28 days)Aprotinin (12000 kIU) (for 28 days)
5left ventricle end-diastolic wall stressSDmale4g/cm2sham surgical control condition (for 2 days)99387sham surgical control condition (for 2 days)
5left ventricle end-diastolic wall stressSDmale16g/cm2artificial aortocaval fistula (for 2 days)99388artificial aortocaval fistula (for 2 days)
5left ventricle end-diastolic wall stressSDmale6g/cm2sham surgical control condition (for 2 days) then Aprotinin (12000 kIU) (for 2 days)99389sham surgical control condition (for 2 days)Aprotinin (12000 kIU) (for 2 days)
5left ventricle end-diastolic wall stressSDmale16g/cm2artificial aortocaval fistula (for 2 days) then Aprotinin (12000 kIU) (for 2 days)99390artificial aortocaval fistula (for 2 days)Aprotinin (12000 kIU) (for 2 days)
7left ventricle end-diastolic wall stressSDmale4g/cm2sham surgical control condition (for 28 days)99391sham surgical control condition (for 28 days)
8left ventricle end-diastolic wall stressSDmale15g/cm2artificial aortocaval fistula (for 28 days)99392artificial aortocaval fistula (for 28 days)
7left ventricle end-diastolic wall stressSDmale4g/cm2sham surgical control condition (for 28 days) then Aprotinin (12000 kIU) (for 28 days)99393sham surgical control condition (for 28 days)Aprotinin (12000 kIU) (for 28 days)
8left ventricle end-diastolic wall stressSDmale16g/cm2artificial aortocaval fistula (for 28 days) then Aprotinin (12000 kIU) (for 28 days)99394artificial aortocaval fistula (for 28 days)Aprotinin (12000 kIU) (for 28 days)
5left ventricle end-systolic wall stressSDmale50g/cm2sham surgical control condition (for 2 days)99395sham surgical control condition (for 2 days)
5left ventricle end-systolic wall stressSDmale54g/cm2artificial aortocaval fistula (for 2 days)99396artificial aortocaval fistula (for 2 days)
5left ventricle end-systolic wall stressSDmale49g/cm2sham surgical control condition (for 2 days) then Aprotinin (12000 kIU) (for 2 days)99397sham surgical control condition (for 2 days)Aprotinin (12000 kIU) (for 2 days)
5left ventricle end-systolic wall stressSDmale37g/cm2artificial aortocaval fistula (for 2 days) then Aprotinin (12000 kIU) (for 2 days)99398artificial aortocaval fistula (for 2 days)Aprotinin (12000 kIU) (for 2 days)
7left ventricle end-systolic wall stressSDmale65g/cm2sham surgical control condition (for 28 days)99399sham surgical control condition (for 28 days)
8left ventricle end-systolic wall stressSDmale81g/cm2artificial aortocaval fistula (for 28 days)99400artificial aortocaval fistula (for 28 days)
7left ventricle end-systolic wall stressSDmale68g/cm2sham surgical control condition (for 28 days) then Aprotinin (12000 kIU) (for 28 days)99401sham surgical control condition (for 28 days)Aprotinin (12000 kIU) (for 28 days)
8left ventricle end-systolic wall stressSDmale62g/cm2artificial aortocaval fistula (for 28 days) then Aprotinin (12000 kIU) (for 28 days)99402artificial aortocaval fistula (for 28 days)Aprotinin (12000 kIU) (for 28 days)
5ratio of the area occupied by interstitial collagen to the total area of the heart left ventricleSDmale3.9%sham surgical control condition (for 2 days)99403sham surgical control condition (for 2 days)
5ratio of the area occupied by interstitial collagen to the total area of the heart left ventricleSDmale2.1%artificial aortocaval fistula (for 2 days)99404artificial aortocaval fistula (for 2 days)
5ratio of the area occupied by interstitial collagen to the total area of the heart left ventricleSDmale4%sham surgical control condition (for 2 days) then Aprotinin (12000 kIU) (for 2 days)99405sham surgical control condition (for 2 days)Aprotinin (12000 kIU) (for 2 days)
5ratio of the area occupied by interstitial collagen to the total area of the heart left ventricleSDmale3.6%artificial aortocaval fistula (for 2 days) then Aprotinin (12000 kIU) (for 2 days)99406artificial aortocaval fistula (for 2 days)Aprotinin (12000 kIU) (for 2 days)
7ratio of the area occupied by interstitial collagen to the total area of the heart left ventricleSDmale3.5%sham surgical control condition (for 28 days)99407sham surgical control condition (for 28 days)
7ratio of the area occupied by interstitial collagen to the total area of the heart left ventricleSDmale2.4%artificial aortocaval fistula (for 28 days)99408artificial aortocaval fistula (for 28 days)
8ratio of the area occupied by interstitial collagen to the total area of the heart left ventricleSDmale3.5%artificial aortocaval fistula (for 28 days) then Aprotinin (12000 kIU) (for 28 days)99409artificial aortocaval fistula (for 28 days)Aprotinin (12000 kIU) (for 28 days)
8ratio of the area occupied by interstitial collagen to the total area of the heart left ventricleSDmale3.2%artificial aortocaval fistula (for 28 days) then Aprotinin (12000 kIU) (for 28 days)99410artificial aortocaval fistula (for 28 days)Aprotinin (12000 kIU) (for 28 days)
8body weightSDmale526gstreptozotocin (60 mg/kg) then insulin99871streptozotocin (60 mg/kg) insulin
8body weightSDmale563gstreptozotocin (60 mg/kg) then insulin then Moexipril (30~35 mg/kg/d) (for 112 days)99891streptozotocin (60 mg/kg) insulinMoexipril (30~35 mg/kg/d) (for 112 days)
8body weightSDmale675gnaive control condition99892naive control condition
8left kidney wet weightSDmale1.94gstreptozotocin (60 mg/kg) then insulin99893streptozotocin (60 mg/kg) insulin
8left kidney wet weightSDmale1.9gstreptozotocin (60 mg/kg) then insulin then Moexipril (30~35 mg/kg/d) (for 112 days)99894streptozotocin (60 mg/kg) insulinMoexipril (30~35 mg/kg/d) (for 112 days)
8left kidney wet weightSDmale1.66gnaive control condition99895naive control condition
8blood glucose levelSDmale334mg/dlstreptozotocin (60 mg/kg) then insulin99896streptozotocin (60 mg/kg) insulin
8blood glucose levelSDmale343mg/dlstreptozotocin (60 mg/kg) then insulin then Moexipril (30~35 mg/kg/d) (for 112 days)99897streptozotocin (60 mg/kg) insulinMoexipril (30~35 mg/kg/d) (for 112 days)
8blood glucose levelSDmale106mg/dlnaive control condition99898naive control condition
8systolic blood pressureSDmale152mmHgstreptozotocin (60 mg/kg) then insulin99899streptozotocin (60 mg/kg) insulin
8systolic blood pressureSDmale128mmHgstreptozotocin (60 mg/kg) then insulin then Moexipril (30~35 mg/kg/d) (for 112 days)99900streptozotocin (60 mg/kg) insulinMoexipril (30~35 mg/kg/d) (for 112 days)
8systolic blood pressureSDmale127mmHgnaive control condition99901naive control condition
8glomerular filtration rate to body weight ratioSDmale0.67ml/min/100gstreptozotocin (60 mg/kg) then insulin99902streptozotocin (60 mg/kg) insulin
8glomerular filtration rate to body weight ratioSDmale0.68ml/min/100gstreptozotocin (60 mg/kg) then insulin then Moexipril (30~35 mg/kg/d) (for 112 days)99903streptozotocin (60 mg/kg) insulinMoexipril (30~35 mg/kg/d) (for 112 days)
8glomerular filtration rate to body weight ratioSDmale0.67ml/min/100gnaive control condition99904naive control condition
8effective renal plasma flowSDmale2.28ml/min/100gstreptozotocin (60 mg/kg) then insulin99905streptozotocin (60 mg/kg) insulin
8effective renal plasma flowSDmale2.31ml/min/100gstreptozotocin (60 mg/kg) then insulin then Moexipril (30~35 mg/kg/d) (for 112 days)99906streptozotocin (60 mg/kg) insulinMoexipril (30~35 mg/kg/d) (for 112 days)
8effective renal plasma flowSDmale2.24ml/min/100gnaive control condition99907naive control condition
8renal filtration fractionSDmale0.3streptozotocin (60 mg/kg) then insulin99911streptozotocin (60 mg/kg) insulin
8renal filtration fractionSDmale0.29streptozotocin (60 mg/kg) then insulin then Moexipril (30~35 mg/kg/d) (for 112 days)99912streptozotocin (60 mg/kg) insulinMoexipril (30~35 mg/kg/d) (for 112 days)
8renal filtration fractionSDmale0.3naive control condition99913naive control condition
8body weightSDmale588gstreptozotocin (60 mg/kg) then insulin99914streptozotocin (60 mg/kg) insulin
8body weightSDmale570gstreptozotocin (60 mg/kg) then insulin then Moexipril (30~35 mg/kg/d) (for 112 days)99915streptozotocin (60 mg/kg) insulinMoexipril (30~35 mg/kg/d) (for 112 days)
8body weightSDmale738gnaive control condition99916naive control condition
8left kidney wet weightSDmale2.18gstreptozotocin (60 mg/kg) then insulin99917streptozotocin (60 mg/kg) insulin
8left kidney wet weightSDmale2.14gstreptozotocin (60 mg/kg) then insulin then Moexipril (30~35 mg/kg/d) (for 112 days)99918streptozotocin (60 mg/kg) insulinMoexipril (30~35 mg/kg/d) (for 112 days)
8left kidney wet weightSDmale1.83gnaive control condition99919naive control condition
8blood glucose levelSDmale358mg/dlstreptozotocin (60 mg/kg) then insulin99920streptozotocin (60 mg/kg) insulin
8blood glucose levelSDmale350mg/dlstreptozotocin (60 mg/kg) then insulin then Moexipril (30~35 mg/kg/d) (for 112 days)99921streptozotocin (60 mg/kg) insulinMoexipril (30~35 mg/kg/d) (for 112 days)
8blood glucose levelSDmale98mg/dlnaive control condition99922naive control condition
8systolic blood pressureSDmale150mmHgstreptozotocin (60 mg/kg) then insulin99923streptozotocin (60 mg/kg) insulin
8systolic blood pressureSDmale128mmHgstreptozotocin (60 mg/kg) then insulin then Moexipril (30~35 mg/kg/d) (for 112 days)99924streptozotocin (60 mg/kg) insulinMoexipril (30~35 mg/kg/d) (for 112 days)
8systolic blood pressureSDmale126mmHgnaive control condition99925naive control condition
8glomerular filtration rate to body weight ratioSDmale0.67ml/min/100gstreptozotocin (60 mg/kg) then insulin99926streptozotocin (60 mg/kg) insulin
8glomerular filtration rate to body weight ratioSDmale0.65ml/min/100gstreptozotocin (60 mg/kg) then insulin then Moexipril (30~35 mg/kg/d) (for 112 days)99927streptozotocin (60 mg/kg) insulinMoexipril (30~35 mg/kg/d) (for 112 days)
8glomerular filtration rate to body weight ratioSDmale0.69ml/min/100gnaive control condition99928naive control condition
8effective renal plasma flowSDmale2.31ml/min/100gstreptozotocin (60 mg/kg) then insulin99929streptozotocin (60 mg/kg) insulin
8effective renal plasma flowSDmale2.27ml/min/100gstreptozotocin (60 mg/kg) then insulin then Moexipril (30~35 mg/kg/d) (for 112 days)99930streptozotocin (60 mg/kg) insulinMoexipril (30~35 mg/kg/d) (for 112 days)
8effective renal plasma flowSDmale2.33ml/min/100gnaive control condition99931naive control condition
8renal filtration fractionSDmale0.29streptozotocin (60 mg/kg) then insulin99932streptozotocin (60 mg/kg) insulin
8renal filtration fractionSDmale0.29streptozotocin (60 mg/kg) then insulin then Moexipril (30~35 mg/kg/d) (for 112 days)99933streptozotocin (60 mg/kg) insulinMoexipril (30~35 mg/kg/d) (for 112 days)
8renal filtration fractionSDmale0.29naive control condition99934naive control condition
6systolic blood pressureSDmale113.6mmHgcontrolled content diet (1.2 %) (for 70 days) then controlled calcium content diet (1 %) (for 70 days)100112controlled content diet (1.2 %) (for 70 days)controlled calcium content diet (1 %) (for 70 days)
6systolic blood pressureSDmale142.8mmHgnephrectomy then controlled content diet (1.2 %) (for 70 days) then controlled calcium content diet (1 %) (for 70 days)100114nephrectomycontrolled content diet (1.2 %) (for 70 days)controlled calcium content diet (1 %) (for 70 days)
8systolic blood pressureSDmale134.3mmHgnephrectomy then controlled content diet (1.2 %) (for 70 days) then controlled calcium content diet (1 %) (for 70 days) and paricalcitol (0.1 ug/kg) (for 70 days)100116nephrectomycontrolled content diet (1.2 %) (for 70 days)controlled calcium content diet (1 %) (for 70 days)paricalcitol (0.1 ug/kg) (for 70 days)
6systolic blood pressureSDmale142.6mmHgnephrectomy then controlled content diet (1.2 %) (for 70 days) then controlled calcium content diet (1 %) (for 70 days) and paricalcitol (0.3 ug/kg) (for 70 days)100118nephrectomycontrolled content diet (1.2 %) (for 70 days)controlled calcium content diet (1 %) (for 70 days)paricalcitol (0.3 ug/kg) (for 70 days)
6blood glucose levelSDmale134.7mg/dlnephrectomy then controlled content diet (1.2 %) (for 70 days) then controlled content diet (1 %) (for 70 days)100120nephrectomycontrolled content diet (1.2 %) (for 70 days)controlled content diet (1 %) (for 70 days)
8blood glucose levelSDmale137.7mg/dlnephrectomy then controlled content diet (1.2 %) (for 70 days) then controlled content diet (1 %) (for 70 days) and paricalcitol (0.1 ug/kg) (for 70 days)100122nephrectomycontrolled content diet (1.2 %) (for 70 days)controlled content diet (1 %) (for 70 days)paricalcitol (0.1 ug/kg) (for 70 days)
6blood glucose levelSDmale138.6mg/dlnephrectomy then controlled content diet (1.2 %) (for 70 days) then controlled content diet (1 %) (for 70 days) and paricalcitol (0.3 ug/kg) (for 70 days)100124nephrectomycontrolled content diet (1.2 %) (for 70 days)controlled content diet (1 %) (for 70 days)paricalcitol (0.3 ug/kg) (for 70 days)
6blood hemoglobin A1c levelSDmale3.2%controlled content diet (1.2 %) (for 70 days) then controlled content diet (1 %) (for 70 days)100126controlled content diet (1.2 %) (for 70 days)controlled content diet (1 %) (for 70 days)
6blood hemoglobin A1c levelSDmale3.2%nephrectomy then controlled content diet (1.2 %) (for 70 days) then controlled content diet (1 %) (for 70 days)100128nephrectomycontrolled content diet (1.2 %) (for 70 days)controlled content diet (1 %) (for 70 days)
8blood hemoglobin A1c levelSDmale3.2%nephrectomy then controlled content diet (1.2 %) (for 70 days) then controlled content diet (1 %) (for 70 days) and paricalcitol (0.1 ug/kg) (for 70 days)100130nephrectomycontrolled content diet (1.2 %) (for 70 days)controlled content diet (1 %) (for 70 days)paricalcitol (0.1 ug/kg) (for 70 days)
6blood hemoglobin A1c levelSDmale3.3%nephrectomy then controlled content diet (1.2 %) (for 70 days) then controlled content diet (1 %) (for 70 days) and paricalcitol (0.3 ug/kg) (for 70 days)100132nephrectomycontrolled content diet (1.2 %) (for 70 days)controlled content diet (1 %) (for 70 days)paricalcitol (0.3 ug/kg) (for 70 days)
6creatinine clearanceSDmale5.2ml/mincontrolled content diet (1.2 %) (for 70 days) then controlled content diet (1 %) (for 70 days)100134controlled content diet (1.2 %) (for 70 days)controlled content diet (1 %) (for 70 days)
6creatinine clearanceSDmale2.6ml/minnephrectomy then controlled content diet (1.2 %) (for 70 days) then controlled content diet (1 %) (for 70 days)100136nephrectomycontrolled content diet (1.2 %) (for 70 days)controlled content diet (1 %) (for 70 days)
8creatinine clearanceSDmale2.3ml/minnephrectomy then controlled content diet (1.2 %) (for 70 days) then controlled content diet (1 %) (for 70 days) and paricalcitol (0.1 ug/kg) (for 70 days)100138nephrectomycontrolled content diet (1.2 %) (for 70 days)controlled content diet (1 %) (for 70 days)paricalcitol (0.1 ug/kg) (for 70 days)
6creatinine clearanceSDmale2.3ml/minnephrectomy then controlled content diet (1.2 %) (for 70 days) then controlled content diet (1 %) (for 70 days) and paricalcitol (0.3 ug/kg) (for 70 days)100140nephrectomycontrolled content diet (1.2 %) (for 70 days)controlled content diet (1 %) (for 70 days)paricalcitol (0.3 ug/kg) (for 70 days)
6blood urea nitrogen levelSDmale17.7mg/dlcontrolled content diet (1.2 %) (for 70 days) then controlled content diet (1 %) (for 70 days)100152controlled content diet (1.2 %) (for 70 days)controlled content diet (1 %) (for 70 days)
6blood urea nitrogen levelSDmale34.2mg/dlnephrectomy then controlled content diet (1.2 %) (for 70 days) then controlled content diet (1 %) (for 70 days)100154nephrectomycontrolled content diet (1.2 %) (for 70 days)controlled content diet (1 %) (for 70 days)
8blood urea nitrogen levelSDmale36.5mg/dlnephrectomy then controlled content diet (1.2 %) (for 70 days) then controlled content diet (1 %) (for 70 days) and paricalcitol (0.1 ug/kg) (for 70 days)100156nephrectomycontrolled content diet (1.2 %) (for 70 days)controlled content diet (1 %) (for 70 days)paricalcitol (0.1 ug/kg) (for 70 days)
6blood urea nitrogen levelSDmale38.2mg/dlnephrectomy then controlled content diet (1.2 %) (for 70 days) then controlled content diet (1 %) (for 70 days) and paricalcitol (0.3 ug/kg) (for 70 days)100158nephrectomycontrolled content diet (1.2 %) (for 70 days)controlled content diet (1 %) (for 70 days)paricalcitol (0.3 ug/kg) (for 70 days)
6blood albumin levelSDmale3.7g/dlcontrolled content diet (1.2 %) (for 70 days) then controlled content diet (1 %) (for 70 days)100160controlled content diet (1.2 %) (for 70 days)controlled content diet (1 %) (for 70 days)
6blood albumin levelSDmale3g/dlnephrectomy then controlled content diet (1.2 %) (for 70 days) then controlled content diet (1 %) (for 70 days)100162nephrectomycontrolled content diet (1.2 %) (for 70 days)controlled content diet (1 %) (for 70 days)
6blood albumin levelSDmale3.2g/dlnephrectomy then controlled content diet (1.2 %) (for 70 days) then controlled content diet (1 %) (for 70 days) and paricalcitol (0.3 ug/kg) (for 70 days)100165nephrectomycontrolled content diet (1.2 %) (for 70 days)controlled content diet (1 %) (for 70 days)paricalcitol (0.3 ug/kg) (for 70 days)
7blood albumin levelSDmale3.1g/dlnephrectomy then controlled content diet (1.2 %) (for 70 days) then controlled content diet (1 %) (for 70 days) and paricalcitol (0.1 ug/kg) (for 70 days)100166nephrectomycontrolled content diet (1.2 %) (for 70 days)controlled content diet (1 %) (for 70 days)paricalcitol (0.1 ug/kg) (for 70 days)
1systolic blood pressureSDmale117mmHgenalapril (5 ml/kg/d) (for 10 days)100178enalapril (5 ml/kg/d) (for 10 days)
1systolic blood pressureSDmale121mmHgnaive control condition100188naive control condition
1systolic blood pressureSDmale119mmHgnaive control condition100189naive control condition
1systolic blood pressureSDmale116mmHglosartan (5 ml/kg/d) (for 10 days)100190losartan (5 ml/kg/d) (for 10 days)
8body weightSDfemale305.4gnaive control condition100631naive control condition
13body weightSDfemale283.6gcontrolled calcium content diet (0.6 %) (for 97 days) and controlled content diet (0.9 %) (for 97 days) and unilateral nephrectomy (for 97 days) then vehicle control condition (100 ul) (for 90 days)100632controlled calcium content diet (0.6 %) (for 97 days)controlled content diet (0.9 %) (for 97 days)unilateral nephrectomy (for 97 days)vehicle control condition (100 ul) (for 90 days)
12body weightSDfemale281.9gcontrolled calcium content diet (0.6 %) (for 97 days) and controlled content diet (0.9 %) (for 97 days) and unilateral nephrectomy (for 97 days) then enalapril (25 mg/l) (for 90 days)100633controlled calcium content diet (0.6 %) (for 97 days)controlled content diet (0.9 %) (for 97 days)unilateral nephrectomy (for 97 days)enalapril (25 mg/l) (for 90 days)
10body weightSDfemale291.9gcontrolled calcium content diet (0.6 %) (for 97 days) and controlled content diet (0.9 %) (for 97 days) and unilateral nephrectomy (for 97 days) then paricalcitol (0.8 mg/kg) (for 90 days)100634controlled calcium content diet (0.6 %) (for 97 days)controlled content diet (0.9 %) (for 97 days)unilateral nephrectomy (for 97 days)paricalcitol (0.8 mg/kg) (for 90 days)
12body weightSDfemale290.6gcontrolled calcium content diet (0.6 %) (for 97 days) and controlled content diet (0.9 %) (for 97 days) and unilateral nephrectomy (for 97 days) then paricalcitol (0.8 mg/kg) (for 90 days) and enalapril (25 mg/l) (for 90 days)100635controlled calcium content diet (0.6 %) (for 97 days)controlled content diet (0.9 %) (for 97 days)unilateral nephrectomy (for 97 days)paricalcitol (0.8 mg/kg) (for 90 days)enalapril (25 mg/l) (for 90 days)
8serum creatinine levelSDfemale0.58mg/dlnaive control condition100636naive control condition
13serum creatinine levelSDfemale1.65mg/dlcontrolled calcium content diet (0.6 %) (for 97 days) and controlled content diet (0.9 %) (for 97 days) and unilateral nephrectomy (for 97 days) then vehicle control condition (100 ul) (for 90 days)100637controlled calcium content diet (0.6 %) (for 97 days)controlled content diet (0.9 %) (for 97 days)unilateral nephrectomy (for 97 days)vehicle control condition (100 ul) (for 90 days)
12serum creatinine levelSDfemale0.93mg/dlcontrolled calcium content diet (0.6 %) (for 97 days) and controlled content diet (0.9 %) (for 97 days) and unilateral nephrectomy (for 97 days) then enalapril (25 mg/l) (for 90 days)100638controlled calcium content diet (0.6 %) (for 97 days)controlled content diet (0.9 %) (for 97 days)unilateral nephrectomy (for 97 days)enalapril (25 mg/l) (for 90 days)
10serum creatinine levelSDfemale1.5mg/dlcontrolled calcium content diet (0.6 %) (for 97 days) and controlled content diet (0.9 %) (for 97 days) and unilateral nephrectomy (for 97 days) then paricalcitol (0.8 mg/kg) (for 90 days)100639controlled calcium content diet (0.6 %) (for 97 days)controlled content diet (0.9 %) (for 97 days)unilateral nephrectomy (for 97 days)paricalcitol (0.8 mg/kg) (for 90 days)
12serum creatinine levelSDfemale0.93mg/dlcontrolled calcium content diet (0.6 %) (for 97 days) and controlled content diet (0.9 %) (for 97 days) and unilateral nephrectomy (for 97 days) then paricalcitol (0.8 mg/kg) (for 90 days) and enalapril (25 mg/l) (for 90 days)100640controlled calcium content diet (0.6 %) (for 97 days)controlled content diet (0.9 %) (for 97 days)unilateral nephrectomy (for 97 days)paricalcitol (0.8 mg/kg) (for 90 days)enalapril (25 mg/l) (for 90 days)
8creatinine clearanceSDfemale0.96ml/minnaive control condition100641naive control condition
13creatinine clearanceSDfemale0.3ml/mincontrolled calcium content diet (0.6 %) (for 97 days) and controlled content diet (0.9 %) (for 97 days) and unilateral nephrectomy (for 97 days) then vehicle control condition (100 ul) (for 90 days)100642controlled calcium content diet (0.6 %) (for 97 days)controlled content diet (0.9 %) (for 97 days)unilateral nephrectomy (for 97 days)vehicle control condition (100 ul) (for 90 days)
12creatinine clearanceSDfemale0.56ml/mincontrolled calcium content diet (0.6 %) (for 97 days) and controlled content diet (0.9 %) (for 97 days) and unilateral nephrectomy (for 97 days) then enalapril (25 mg/l) (for 90 days)100643controlled calcium content diet (0.6 %) (for 97 days)controlled content diet (0.9 %) (for 97 days)unilateral nephrectomy (for 97 days)enalapril (25 mg/l) (for 90 days)
10creatinine clearanceSDfemale0.35ml/mincontrolled calcium content diet (0.6 %) (for 97 days) and controlled content diet (0.9 %) (for 97 days) and unilateral nephrectomy (for 97 days) then paricalcitol (0.8 mg/kg) (for 90 days)100644controlled calcium content diet (0.6 %) (for 97 days)controlled content diet (0.9 %) (for 97 days)unilateral nephrectomy (for 97 days)paricalcitol (0.8 mg/kg) (for 90 days)
12creatinine clearanceSDfemale0.58ml/mincontrolled calcium content diet (0.6 %) (for 97 days) and controlled content diet (0.9 %) (for 97 days) and unilateral nephrectomy (for 97 days) then paricalcitol (0.8 mg/kg) (for 90 days) and enalapril (25 mg/l) (for 90 days)100645controlled calcium content diet (0.6 %) (for 97 days)controlled content diet (0.9 %) (for 97 days)unilateral nephrectomy (for 97 days)paricalcitol (0.8 mg/kg) (for 90 days)enalapril (25 mg/l) (for 90 days)
8serum parathyroid hormone levelSDfemale83pg/mlnaive control condition100646naive control condition
13serum parathyroid hormone levelSDfemale3496pg/mlcontrolled calcium content diet (0.6 %) (for 97 days) and controlled content diet (0.9 %) (for 97 days) and unilateral nephrectomy (for 97 days) then vehicle control condition (100 ul) (for 90 days)100647controlled calcium content diet (0.6 %) (for 97 days)controlled content diet (0.9 %) (for 97 days)unilateral nephrectomy (for 97 days)vehicle control condition (100 ul) (for 90 days)
12serum parathyroid hormone levelSDfemale371pg/mlcontrolled calcium content diet (0.6 %) (for 97 days) and controlled content diet (0.9 %) (for 97 days) and unilateral nephrectomy (for 97 days) then enalapril (25 mg/l) (for 90 days)100648controlled calcium content diet (0.6 %) (for 97 days)controlled content diet (0.9 %) (for 97 days)unilateral nephrectomy (for 97 days)enalapril (25 mg/l) (for 90 days)
10serum parathyroid hormone levelSDfemale629pg/mlcontrolled calcium content diet (0.6 %) (for 97 days) and controlled content diet (0.9 %) (for 97 days) and unilateral nephrectomy (for 97 days) then paricalcitol (0.8 mg/kg) (for 90 days)100649controlled calcium content diet (0.6 %) (for 97 days)controlled content diet (0.9 %) (for 97 days)unilateral nephrectomy (for 97 days)paricalcitol (0.8 mg/kg) (for 90 days)
12serum parathyroid hormone levelSDfemale170pg/mlcontrolled calcium content diet (0.6 %) (for 97 days) and controlled content diet (0.9 %) (for 97 days) and unilateral nephrectomy (for 97 days) then paricalcitol (0.8 mg/kg) (for 90 days) and enalapril (25 mg/l) (for 90 days)100650controlled calcium content diet (0.6 %) (for 97 days)controlled content diet (0.9 %) (for 97 days)unilateral nephrectomy (for 97 days)paricalcitol (0.8 mg/kg) (for 90 days)enalapril (25 mg/l) (for 90 days)
6body weightSDmale403.2gleft anterior descending coronary artery occlusion (for 28 days)101075left anterior descending coronary artery occlusion (for 28 days)
6body weightSDmale378.1gsham surgical control condition (for 28 days)101076sham surgical control condition (for 28 days)
10body weightSDmale568.3gleft anterior descending coronary artery occlusion (for 140 days)101077left anterior descending coronary artery occlusion (for 140 days)
6body weightSDmale532.2gsham surgical control condition (for 140 days)101078sham surgical control condition (for 140 days)
6heart weightSDmale1.25gleft anterior descending coronary artery occlusion (for 28 days)101079left anterior descending coronary artery occlusion (for 28 days)
6heart weightSDmale1.13gsham surgical control condition (for 28 days)101080sham surgical control condition (for 28 days)
10heart weightSDmale1.57gleft anterior descending coronary artery occlusion (for 140 days)101081left anterior descending coronary artery occlusion (for 140 days)
6heart weightSDmale1.41gsham surgical control condition (for 140 days)101082sham surgical control condition (for 140 days)
6heart weight to body weight ratioSDmale3.09g/kgleft anterior descending coronary artery occlusion (for 28 days)101083left anterior descending coronary artery occlusion (for 28 days)
6heart weight to body weight ratioSDmale2.92g/kgsham surgical control condition (for 28 days)101084sham surgical control condition (for 28 days)
10heart weight to body weight ratioSDmale2.78g/kgleft anterior descending coronary artery occlusion (for 140 days)101085left anterior descending coronary artery occlusion (for 140 days)
6heart weight to body weight ratioSDmale2.66g/kgsham surgical control condition (for 140 days)101086sham surgical control condition (for 140 days)
6systolic blood pressureSDmale125mmHgleft anterior descending coronary artery occlusion (for 28 days)101087left anterior descending coronary artery occlusion (for 28 days)
6systolic blood pressureSDmale134mmHgsham surgical control condition (for 28 days)101088sham surgical control condition (for 28 days)
10systolic blood pressureSDmale143mmHgleft anterior descending coronary artery occlusion (for 140 days)101089left anterior descending coronary artery occlusion (for 140 days)
6systolic blood pressureSDmale144mmHgsham surgical control condition (for 140 days)101090sham surgical control condition (for 140 days)
6heart left ventricle weightSDmale0.67gleft anterior descending coronary artery occlusion (for 28 days)101091left anterior descending coronary artery occlusion (for 28 days)
6heart left ventricle weightSDmale0.6gsham surgical control condition (for 28 days)101092sham surgical control condition (for 28 days)
10heart left ventricle weightSDmale0.87gleft anterior descending coronary artery occlusion (for 140 days)101093left anterior descending coronary artery occlusion (for 140 days)
6heart left ventricle weightSDmale0.76gsham surgical control condition (for 140 days)101094sham surgical control condition (for 140 days)
6heart left ventricle weight to body weight ratioSDmale1.67mg/gleft anterior descending coronary artery occlusion (for 28 days)101095left anterior descending coronary artery occlusion (for 28 days)
6heart left ventricle weight to body weight ratioSDmale1.56mg/gsham surgical control condition (for 28 days)101096sham surgical control condition (for 28 days)
10heart left ventricle weight to body weight ratioSDmale1.53mg/gleft anterior descending coronary artery occlusion (for 140 days)101097left anterior descending coronary artery occlusion (for 140 days)
6heart left ventricle weight to body weight ratioSDmale1.44mg/gsham surgical control condition (for 140 days)101098sham surgical control condition (for 140 days)
6heart right ventricle weightSDmale0.25gleft anterior descending coronary artery occlusion (for 28 days)101099left anterior descending coronary artery occlusion (for 28 days)
6heart right ventricle weightSDmale0.23gsham surgical control condition (for 28 days)101100sham surgical control condition (for 28 days)
10heart right ventricle weightSDmale0.29gleft anterior descending coronary artery occlusion (for 140 days)101101left anterior descending coronary artery occlusion (for 140 days)
6heart right ventricle weightSDmale0.27gsham surgical control condition (for 140 days)101102sham surgical control condition (for 140 days)
6heart right ventricle weight to body weight ratioSDmale0.62mg/gleft anterior descending coronary artery occlusion (for 28 days)101103left anterior descending coronary artery occlusion (for 28 days)
6heart right ventricle weight to body weight ratioSDmale0.59mg/gsham surgical control condition (for 28 days)101104sham surgical control condition (for 28 days)
10heart right ventricle weight to body weight ratioSDmale0.52mg/gleft anterior descending coronary artery occlusion (for 140 days)101105left anterior descending coronary artery occlusion (for 140 days)
6heart right ventricle weight to body weight ratioSDmale0.51mg/gsham surgical control condition (for 140 days)101106sham surgical control condition (for 140 days)
6left atrium weightSDmale0.04gleft anterior descending coronary artery occlusion (for 28 days)101107left anterior descending coronary artery occlusion (for 28 days)
6left atrium weightSDmale0.03gsham surgical control condition (for 28 days)101108sham surgical control condition (for 28 days)
10left atrium weightSDmale0.05gleft anterior descending coronary artery occlusion (for 140 days)101109left anterior descending coronary artery occlusion (for 140 days)
6left atrium weightSDmale0.04gsham surgical control condition (for 140 days)101110sham surgical control condition (for 140 days)
6heart left atrium weight to body weight ratioSDmale0.1mg/gleft anterior descending coronary artery occlusion (for 28 days)101111left anterior descending coronary artery occlusion (for 28 days)
6heart left atrium weight to body weight ratioSDmale0.07mg/gsham surgical control condition (for 28 days)101112sham surgical control condition (for 28 days)
10heart left atrium weight to body weight ratioSDmale0.08mg/gleft anterior descending coronary artery occlusion (for 140 days)101113left anterior descending coronary artery occlusion (for 140 days)
6heart left atrium weight to body weight ratioSDmale0.08mg/gsham surgical control condition (for 140 days)101114sham surgical control condition (for 140 days)
6right atrium weightSDmale0.04gleft anterior descending coronary artery occlusion (for 28 days)101115left anterior descending coronary artery occlusion (for 28 days)
6right atrium weightSDmale0.04gsham surgical control condition (for 28 days)101116sham surgical control condition (for 28 days)
10right atrium weightSDmale0.05gleft anterior descending coronary artery occlusion (for 140 days)101117left anterior descending coronary artery occlusion (for 140 days)
6right atrium weightSDmale0.04gsham surgical control condition (for 140 days)101118sham surgical control condition (for 140 days)
6heart right atrium weight to body weight ratioSDmale0.11mg/gleft anterior descending coronary artery occlusion (for 28 days)101119left anterior descending coronary artery occlusion (for 28 days)
6heart right atrium weight to body weight ratioSDmale0.1mg/gsham surgical control condition (for 28 days)101120sham surgical control condition (for 28 days)
10heart right atrium weight to body weight ratioSDmale0.09mg/gleft anterior descending coronary artery occlusion (for 140 days)101121left anterior descending coronary artery occlusion (for 140 days)
6heart right atrium weight to body weight ratioSDmale0.08mg/gsham surgical control condition (for 140 days)101122sham surgical control condition (for 140 days)
6heart septum weightSDmale0.24gleft anterior descending coronary artery occlusion (for 28 days)101123left anterior descending coronary artery occlusion (for 28 days)
6heart septum weightSDmale0.23gsham surgical control condition (for 28 days)101124sham surgical control condition (for 28 days)
10heart septum weightSDmale0.33gleft anterior descending coronary artery occlusion (for 140 days)101125left anterior descending coronary artery occlusion (for 140 days)
6heart septum weightSDmale0.29gsham surgical control condition (for 140 days)101126sham surgical control condition (for 140 days)
6calculated heart left ventricle infarction areaSDmale35.4%left anterior descending coronary artery occlusion (for 28 days)101127left anterior descending coronary artery occlusion (for 28 days)
10calculated heart left ventricle infarction areaSDmale37.9%left anterior descending coronary artery occlusion (for 140 days)101128left anterior descending coronary artery occlusion (for 140 days)
6body weightSDmale336gsham surgical control condition (between 12 and 14 days)101535sham surgical control condition (between 12 and 14 days)
11body weightSDmale277gunilateral nephrectomy (between 12 and 14 days)101536unilateral nephrectomy (between 12 and 14 days)
5body weightSDmale285gunilateral nephrectomy (between 12 and 14 days) then enalapril (50 mg/l) (between 12 and 14 days) and losartan (180 mg/l) (between 12 and 14 days)101537unilateral nephrectomy (between 12 and 14 days)enalapril (50 mg/l) (between 12 and 14 days)losartan (180 mg/l) (between 12 and 14 days)
5body weightSDmale302gunilateral nephrectomy (between 12 and 14 days) then enalapril (50 mg/l) (between 12 and 14 days) and losartan (180 mg/l) (between 12 and 14 days) and Aldosterone (30~40 mg/kg/d) (between 12 and 14 days)101538unilateral nephrectomy (between 12 and 14 days)enalapril (50 mg/l) (between 12 and 14 days)losartan (180 mg/l) (between 12 and 14 days)Aldosterone (30~40 mg/kg/d) (between 12 and 14 days)
6change in body weightSDmale84gsham surgical control condition (between 12 and 14 days)101539sham surgical control condition (between 12 and 14 days)
11change in body weightSDmale66gunilateral nephrectomy (between 12 and 14 days)101540unilateral nephrectomy (between 12 and 14 days)
5change in body weightSDmale74gunilateral nephrectomy (between 12 and 14 days) then enalapril (50 mg/l) (between 12 and 14 days) and losartan (180 mg/l) (between 12 and 14 days)101541unilateral nephrectomy (between 12 and 14 days)enalapril (50 mg/l) (between 12 and 14 days)losartan (180 mg/l) (between 12 and 14 days)
5change in body weightSDmale66gunilateral nephrectomy (between 12 and 14 days) then enalapril (50 mg/l) (between 12 and 14 days) and losartan (180 mg/l) (between 12 and 14 days) and Aldosterone (30~40 mg/kg/d) (between 12 and 14 days)101542unilateral nephrectomy (between 12 and 14 days)enalapril (50 mg/l) (between 12 and 14 days)losartan (180 mg/l) (between 12 and 14 days)Aldosterone (30~40 mg/kg/d) (between 12 and 14 days)
6left kidney wet weightSDmale1.11gsham surgical control condition (between 12 and 14 days)101543sham surgical control condition (between 12 and 14 days)
11left kidney wet weightSDmale1.37gunilateral nephrectomy (between 12 and 14 days)101544unilateral nephrectomy (between 12 and 14 days)
5left kidney wet weightSDmale1.16gunilateral nephrectomy (between 12 and 14 days) then enalapril (50 mg/l) (between 12 and 14 days) and losartan (180 mg/l) (between 12 and 14 days)101545unilateral nephrectomy (between 12 and 14 days)enalapril (50 mg/l) (between 12 and 14 days)losartan (180 mg/l) (between 12 and 14 days)
5left kidney wet weightSDmale1.49gunilateral nephrectomy (between 12 and 14 days) then enalapril (50 mg/l) (between 12 and 14 days) and losartan (180 mg/l) (between 12 and 14 days) and Aldosterone (30~40 mg/kg/d) (between 12 and 14 days)101546unilateral nephrectomy (between 12 and 14 days)enalapril (50 mg/l) (between 12 and 14 days)losartan (180 mg/l) (between 12 and 14 days)Aldosterone (30~40 mg/kg/d) (between 12 and 14 days)
6systolic blood pressureSDmale118mmHgsham surgical control condition (between 12 and 14 days)101547sham surgical control condition (between 12 and 14 days)
11systolic blood pressureSDmale185mmHgunilateral nephrectomy (between 12 and 14 days)101548unilateral nephrectomy (between 12 and 14 days)
5systolic blood pressureSDmale125mmHgunilateral nephrectomy (between 12 and 14 days) then enalapril (50 mg/l) (between 12 and 14 days) and losartan (180 mg/l) (between 12 and 14 days)101549unilateral nephrectomy (between 12 and 14 days)enalapril (50 mg/l) (between 12 and 14 days)losartan (180 mg/l) (between 12 and 14 days)
5systolic blood pressureSDmale149mmHgunilateral nephrectomy (between 12 and 14 days) then enalapril (50 mg/l) (between 12 and 14 days) and losartan (180 mg/l) (between 12 and 14 days) and Aldosterone (30~40 mg/kg/d) (between 12 and 14 days)101550unilateral nephrectomy (between 12 and 14 days)enalapril (50 mg/l) (between 12 and 14 days)losartan (180 mg/l) (between 12 and 14 days)Aldosterone (30~40 mg/kg/d) (between 12 and 14 days)
6urine protein excretion rateSDmale10mg/dsham surgical control condition (between 12 and 14 days)101551sham surgical control condition (between 12 and 14 days)
11urine protein excretion rateSDmale121mg/dunilateral nephrectomy (between 12 and 14 days)101552unilateral nephrectomy (between 12 and 14 days)
5urine protein excretion rateSDmale31mg/dunilateral nephrectomy (between 12 and 14 days) then enalapril (50 mg/l) (between 12 and 14 days) and losartan (180 mg/l) (between 12 and 14 days)101553unilateral nephrectomy (between 12 and 14 days)enalapril (50 mg/l) (between 12 and 14 days)losartan (180 mg/l) (between 12 and 14 days)
5urine protein excretion rateSDmale87mg/dunilateral nephrectomy (between 12 and 14 days) then enalapril (50 mg/l) (between 12 and 14 days) and losartan (180 mg/l) (between 12 and 14 days) and Aldosterone (30~40 mg/kg/d) (between 12 and 14 days)101554unilateral nephrectomy (between 12 and 14 days)enalapril (50 mg/l) (between 12 and 14 days)losartan (180 mg/l) (between 12 and 14 days)Aldosterone (30~40 mg/kg/d) (between 12 and 14 days)
6plasma aldosterone levelSDmale50pg/mlsham surgical control condition (between 12 and 14 days)101555sham surgical control condition (between 12 and 14 days)
11plasma aldosterone levelSDmale526pg/mlunilateral nephrectomy (between 12 and 14 days)101556unilateral nephrectomy (between 12 and 14 days)
5plasma aldosterone levelSDmale181pg/mlunilateral nephrectomy (between 12 and 14 days) then enalapril (50 mg/l) (between 12 and 14 days) and losartan (180 mg/l) (between 12 and 14 days)101557unilateral nephrectomy (between 12 and 14 days)enalapril (50 mg/l) (between 12 and 14 days)losartan (180 mg/l) (between 12 and 14 days)
5plasma aldosterone levelSDmale487pg/mlunilateral nephrectomy (between 12 and 14 days) then enalapril (50 mg/l) (between 12 and 14 days) and losartan (180 mg/l) (between 12 and 14 days) and Aldosterone (30~40 mg/kg/d) (between 12 and 14 days)101558unilateral nephrectomy (between 12 and 14 days)enalapril (50 mg/l) (between 12 and 14 days)losartan (180 mg/l) (between 12 and 14 days)Aldosterone (30~40 mg/kg/d) (between 12 and 14 days)
6adrenal gland weightSDmale51mgsham surgical control condition (between 12 and 14 days)101559sham surgical control condition (between 12 and 14 days)
11adrenal gland weightSDmale63mgunilateral nephrectomy (between 12 and 14 days)101560unilateral nephrectomy (between 12 and 14 days)
5adrenal gland weightSDmale56mgunilateral nephrectomy (between 12 and 14 days) then enalapril (50 mg/l) (between 12 and 14 days) and losartan (180 mg/l) (between 12 and 14 days)101561unilateral nephrectomy (between 12 and 14 days)enalapril (50 mg/l) (between 12 and 14 days)losartan (180 mg/l) (between 12 and 14 days)
5adrenal gland weightSDmale60mgunilateral nephrectomy (between 12 and 14 days) then enalapril (50 mg/l) (between 12 and 14 days) and losartan (180 mg/l) (between 12 and 14 days) and Aldosterone (30~40 mg/kg/d) (between 12 and 14 days)101562unilateral nephrectomy (between 12 and 14 days)enalapril (50 mg/l) (between 12 and 14 days)losartan (180 mg/l) (between 12 and 14 days)Aldosterone (30~40 mg/kg/d) (between 12 and 14 days)
6plasma renin activity levelSDmale3.1ng/ml/hsham surgical control condition (between 12 and 14 days)101563sham surgical control condition (between 12 and 14 days)
11plasma renin activity levelSDmale4.3ng/ml/hunilateral nephrectomy (between 12 and 14 days)101564unilateral nephrectomy (between 12 and 14 days)
5plasma renin activity levelSDmale13.3ng/ml/hunilateral nephrectomy (between 12 and 14 days) then enalapril (50 mg/l) (between 12 and 14 days) and losartan (180 mg/l) (between 12 and 14 days)101565unilateral nephrectomy (between 12 and 14 days)enalapril (50 mg/l) (between 12 and 14 days)losartan (180 mg/l) (between 12 and 14 days)
5plasma renin activity levelSDmale5.2ng/ml/hunilateral nephrectomy (between 12 and 14 days) then enalapril (50 mg/l) (between 12 and 14 days) and losartan (180 mg/l) (between 12 and 14 days) and Aldosterone (30~40 mg/kg/d) (between 12 and 14 days)101566unilateral nephrectomy (between 12 and 14 days)enalapril (50 mg/l) (between 12 and 14 days)losartan (180 mg/l) (between 12 and 14 days)Aldosterone (30~40 mg/kg/d) (between 12 and 14 days)
6adrenal gland renin levelSDmale2.2ng/ml/hsham surgical control condition (between 12 and 14 days)101567sham surgical control condition (between 12 and 14 days)
11adrenal gland renin levelSDmale1.3ng/ml/hunilateral nephrectomy (between 12 and 14 days)101568unilateral nephrectomy (between 12 and 14 days)
5adrenal gland renin levelSDmale3.6ng/ml/hunilateral nephrectomy (between 12 and 14 days) then enalapril (50 mg/l) (between 12 and 14 days) and losartan (180 mg/l) (between 12 and 14 days)101569unilateral nephrectomy (between 12 and 14 days)enalapril (50 mg/l) (between 12 and 14 days)losartan (180 mg/l) (between 12 and 14 days)
5adrenal gland renin levelSDmale0.5ng/ml/hunilateral nephrectomy (between 12 and 14 days) then enalapril (50 mg/l) (between 12 and 14 days) and losartan (180 mg/l) (between 12 and 14 days) and Aldosterone (30~40 mg/kg/d) (between 12 and 14 days)101570unilateral nephrectomy (between 12 and 14 days)enalapril (50 mg/l) (between 12 and 14 days)losartan (180 mg/l) (between 12 and 14 days)Aldosterone (30~40 mg/kg/d) (between 12 and 14 days)
6body weightSDmale347gsham surgical control condition (for 28 days)101571sham surgical control condition (for 28 days)
7body weightSDmale309gunilateral nephrectomy (for 28 days)101572unilateral nephrectomy (for 28 days)
7body weightSDmale307gunilateral nephrectomy (for 28 days) then enalapril (50 mg/l) (for 28 days) and losartan (180 mg/l) (for 28 days)101573unilateral nephrectomy (for 28 days)enalapril (50 mg/l) (for 28 days)losartan (180 mg/l) (for 28 days)
6body weightSDmale312gunilateral nephrectomy (for 28 days) then enalapril (50 mg/l) (for 28 days) and losartan (180 mg/l) (for 28 days) and Aldosterone (35 mg/kg/d) (for 28 days)101574unilateral nephrectomy (for 28 days)enalapril (50 mg/l) (for 28 days)losartan (180 mg/l) (for 28 days)Aldosterone (35 mg/kg/d) (for 28 days)
6change in body weightSDmale99gsham surgical control condition (for 28 days)101575sham surgical control condition (for 28 days)
7change in body weightSDmale96gunilateral nephrectomy (for 28 days)101576unilateral nephrectomy (for 28 days)
7change in body weightSDmale97gunilateral nephrectomy (for 28 days) then enalapril (50 mg/l) (for 28 days) and losartan (180 mg/l) (for 28 days)101577unilateral nephrectomy (for 28 days)enalapril (50 mg/l) (for 28 days)losartan (180 mg/l) (for 28 days)
6change in body weightSDmale106gunilateral nephrectomy (for 28 days) then enalapril (50 mg/l) (for 28 days) and losartan (180 mg/l) (for 28 days) and Aldosterone (35 mg/kg/d) (for 28 days)101578unilateral nephrectomy (for 28 days)enalapril (50 mg/l) (for 28 days)losartan (180 mg/l) (for 28 days)Aldosterone (35 mg/kg/d) (for 28 days)
6left kidney wet weightSDmale1.19gsham surgical control condition (for 28 days)101579sham surgical control condition (for 28 days)
7left kidney wet weightSDmale1.91gunilateral nephrectomy (for 28 days)101580unilateral nephrectomy (for 28 days)
7left kidney wet weightSDmale1.47gunilateral nephrectomy (for 28 days) then enalapril (50 mg/l) (for 28 days) and losartan (180 mg/l) (for 28 days)101581unilateral nephrectomy (for 28 days)enalapril (50 mg/l) (for 28 days)losartan (180 mg/l) (for 28 days)
6left kidney wet weightSDmale2.03gunilateral nephrectomy (for 28 days) then enalapril (50 mg/l) (for 28 days) and losartan (180 mg/l) (for 28 days) and Aldosterone (35 mg/kg/d) (for 28 days)101582unilateral nephrectomy (for 28 days)enalapril (50 mg/l) (for 28 days)losartan (180 mg/l) (for 28 days)Aldosterone (35 mg/kg/d) (for 28 days)
6systolic blood pressureSDmale118mmHgsham surgical control condition (for 28 days)101583sham surgical control condition (for 28 days)
7systolic blood pressureSDmale212mmHgunilateral nephrectomy (for 28 days)101584unilateral nephrectomy (for 28 days)
7systolic blood pressureSDmale109mmHgunilateral nephrectomy (for 28 days) then enalapril (50 mg/l) (for 28 days) and losartan (180 mg/l) (for 28 days)101585unilateral nephrectomy (for 28 days)enalapril (50 mg/l) (for 28 days)losartan (180 mg/l) (for 28 days)
6systolic blood pressureSDmale186mmHgunilateral nephrectomy (for 28 days) then enalapril (50 mg/l) (for 28 days) and losartan (180 mg/l) (for 28 days) and Aldosterone (35 mg/kg/d) (for 28 days)101586unilateral nephrectomy (for 28 days)enalapril (50 mg/l) (for 28 days)losartan (180 mg/l) (for 28 days)Aldosterone (35 mg/kg/d) (for 28 days)
6heart wet weightSDmale1.03gsham surgical control condition (for 28 days)101587sham surgical control condition (for 28 days)
7heart wet weightSDmale1.33gunilateral nephrectomy (for 28 days)101588unilateral nephrectomy (for 28 days)
7heart wet weightSDmale0.88gunilateral nephrectomy (for 28 days) then enalapril (50 mg/l) (for 28 days) and losartan (180 mg/l) (for 28 days)101589unilateral nephrectomy (for 28 days)enalapril (50 mg/l) (for 28 days)losartan (180 mg/l) (for 28 days)
6heart wet weightSDmale1.28gunilateral nephrectomy (for 28 days) then enalapril (50 mg/l) (for 28 days) and losartan (180 mg/l) (for 28 days) and Aldosterone (35 mg/kg/d) (for 28 days)101590unilateral nephrectomy (for 28 days)enalapril (50 mg/l) (for 28 days)losartan (180 mg/l) (for 28 days)Aldosterone (35 mg/kg/d) (for 28 days)
6urine protein excretion rateSDmale19mg/dsham surgical control condition (for 28 days)101591sham surgical control condition (for 28 days)
7urine protein excretion rateSDmale203mg/dunilateral nephrectomy (for 28 days)101592unilateral nephrectomy (for 28 days)
7urine protein excretion rateSDmale30mg/dunilateral nephrectomy (for 28 days) then enalapril (50 mg/l) (for 28 days) and losartan (180 mg/l) (for 28 days)101593unilateral nephrectomy (for 28 days)enalapril (50 mg/l) (for 28 days)losartan (180 mg/l) (for 28 days)
6urine protein excretion rateSDmale217mg/dunilateral nephrectomy (for 28 days) then enalapril (50 mg/l) (for 28 days) and losartan (180 mg/l) (for 28 days) and Aldosterone (35 mg/kg/d) (for 28 days)101594unilateral nephrectomy (for 28 days)enalapril (50 mg/l) (for 28 days)losartan (180 mg/l) (for 28 days)Aldosterone (35 mg/kg/d) (for 28 days)
6plasma potassium levelSDmale5mmol/lsham surgical control condition (for 28 days)101595sham surgical control condition (for 28 days)
7plasma potassium levelSDmale5mmol/lunilateral nephrectomy (for 28 days)101596unilateral nephrectomy (for 28 days)
7plasma potassium levelSDmale6.2mmol/lunilateral nephrectomy (for 28 days) then enalapril (50 mg/l) (for 28 days) and losartan (180 mg/l) (for 28 days)101597unilateral nephrectomy (for 28 days)enalapril (50 mg/l) (for 28 days)losartan (180 mg/l) (for 28 days)
6plasma potassium levelSDmale4.5mmol/lunilateral nephrectomy (for 28 days) then enalapril (50 mg/l) (for 28 days) and losartan (180 mg/l) (for 28 days) and Aldosterone (35 mg/kg/d) (for 28 days)101598unilateral nephrectomy (for 28 days)enalapril (50 mg/l) (for 28 days)losartan (180 mg/l) (for 28 days)Aldosterone (35 mg/kg/d) (for 28 days)
6adrenal gland weightSDmale46mgsham surgical control condition (for 28 days)101599sham surgical control condition (for 28 days)
7adrenal gland weightSDmale69mgunilateral nephrectomy (for 28 days)101600unilateral nephrectomy (for 28 days)
7adrenal gland weightSDmale57mgunilateral nephrectomy (for 28 days) then enalapril (50 mg/l) (for 28 days) and losartan (180 mg/l) (for 28 days)101601unilateral nephrectomy (for 28 days)enalapril (50 mg/l) (for 28 days)losartan (180 mg/l) (for 28 days)
6adrenal gland weightSDmale60mgunilateral nephrectomy (for 28 days) then enalapril (50 mg/l) (for 28 days) and losartan (180 mg/l) (for 28 days) and Aldosterone (35 mg/kg/d) (for 28 days)101602unilateral nephrectomy (for 28 days)enalapril (50 mg/l) (for 28 days)losartan (180 mg/l) (for 28 days)Aldosterone (35 mg/kg/d) (for 28 days)
6kidney sclerotic glomeruli count to total glomeruli count ratioSDmale1.9%sham surgical control condition (for 28 days)101603sham surgical control condition (for 28 days)
7kidney sclerotic glomeruli count to total glomeruli count ratioSDmale37.2%unilateral nephrectomy (for 28 days)101604unilateral nephrectomy (for 28 days)
7kidney sclerotic glomeruli count to total glomeruli count ratioSDmale4.7%unilateral nephrectomy (for 28 days) then enalapril (50 mg/l) (for 28 days) and losartan (180 mg/l) (for 28 days)101605unilateral nephrectomy (for 28 days)enalapril (50 mg/l) (for 28 days)losartan (180 mg/l) (for 28 days)
6kidney sclerotic glomeruli count to total glomeruli count ratioSDmale25.3%unilateral nephrectomy (for 28 days) then enalapril (50 mg/l) (for 28 days) and losartan (180 mg/l) (for 28 days) and Aldosterone (35 mg/kg/d) (for 28 days)101606unilateral nephrectomy (for 28 days)enalapril (50 mg/l) (for 28 days)losartan (180 mg/l) (for 28 days)Aldosterone (35 mg/kg/d) (for 28 days)
8body weightSDmale315gunilateral nephrectomy (for 28 days)101607unilateral nephrectomy (for 28 days)
8body weightSDmale300gunilateral nephrectomy (for 28 days) then spironolactone (5.56 mg/kg/d) (for 28 days)101608unilateral nephrectomy (for 28 days)spironolactone (5.56 mg/kg/d) (for 28 days)
8change in body weightSDmale59gunilateral nephrectomy (for 28 days)101609unilateral nephrectomy (for 28 days)
8change in body weightSDmale48gunilateral nephrectomy (for 28 days) then spironolactone (5.56 mg/kg/d) (for 28 days)101610unilateral nephrectomy (for 28 days)spironolactone (5.56 mg/kg/d) (for 28 days)
8food intake rateSDmale19g/dunilateral nephrectomy (for 28 days)101611unilateral nephrectomy (for 28 days)
8food intake rateSDmale23g/dunilateral nephrectomy (for 28 days) then spironolactone (5.56 mg/kg/d) (for 28 days)101612unilateral nephrectomy (for 28 days)spironolactone (5.56 mg/kg/d) (for 28 days)
8left kidney wet weightSDmale1.96gunilateral nephrectomy (for 28 days)101613unilateral nephrectomy (for 28 days)
8left kidney wet weightSDmale1.79gunilateral nephrectomy (for 28 days) then spironolactone (5.56 mg/kg/d) (for 28 days)101614unilateral nephrectomy (for 28 days)spironolactone (5.56 mg/kg/d) (for 28 days)
8systolic blood pressureSDmale201mmHgunilateral nephrectomy (for 14 days)101615unilateral nephrectomy (for 14 days)
8systolic blood pressureSDmale192mmHgunilateral nephrectomy (for 14 days) then spironolactone (5.56 mg/kg/d) (for 14 days)101616unilateral nephrectomy (for 14 days)spironolactone (5.56 mg/kg/d) (for 14 days)
8systolic blood pressureSDmale208mmHgunilateral nephrectomy (for 28 days)101617unilateral nephrectomy (for 28 days)
8systolic blood pressureSDmale190mmHgunilateral nephrectomy (for 28 days) then spironolactone (5.56 mg/kg/d) (for 28 days)101618unilateral nephrectomy (for 28 days)spironolactone (5.56 mg/kg/d) (for 28 days)
8heart wet weightSDmale1.33gunilateral nephrectomy (for 28 days)101619unilateral nephrectomy (for 28 days)
8heart wet weightSDmale1.12gunilateral nephrectomy (for 28 days) then spironolactone (5.56 mg/kg/d) (for 28 days)101620unilateral nephrectomy (for 28 days)spironolactone (5.56 mg/kg/d) (for 28 days)
8urine protein excretion rateSDmale201mg/dunilateral nephrectomy (for 14 days)101621unilateral nephrectomy (for 14 days)
8urine protein excretion rateSDmale130mg/dunilateral nephrectomy (for 14 days) then spironolactone (5.56 mg/kg/d) (for 14 days)101622unilateral nephrectomy (for 14 days)spironolactone (5.56 mg/kg/d) (for 14 days)
8urine protein excretion rateSDmale283mg/dunilateral nephrectomy (for 28 days)101623unilateral nephrectomy (for 28 days)
8urine protein excretion rateSDmale243mg/dunilateral nephrectomy (for 28 days) then spironolactone (5.56 mg/kg/d) (for 28 days)101624unilateral nephrectomy (for 28 days)spironolactone (5.56 mg/kg/d) (for 28 days)
8plasma potassium levelSDmale5.3mmol/lunilateral nephrectomy (for 14 days)101625unilateral nephrectomy (for 14 days)
8plasma potassium levelSDmale5.2mmol/lunilateral nephrectomy (for 14 days) then spironolactone (5.56 mg/kg/d) (for 14 days)101626unilateral nephrectomy (for 14 days)spironolactone (5.56 mg/kg/d) (for 14 days)
8adrenal gland weightSDmale71mgunilateral nephrectomy (for 28 days)101627unilateral nephrectomy (for 28 days)
8adrenal gland weightSDmale73mgunilateral nephrectomy (for 28 days) then spironolactone (5.56 mg/kg/d) (for 28 days)101628unilateral nephrectomy (for 28 days)spironolactone (5.56 mg/kg/d) (for 28 days)
8kidney sclerotic glomeruli count to total glomeruli count ratioSDmale31%unilateral nephrectomy (for 28 days)101629unilateral nephrectomy (for 28 days)
8kidney sclerotic glomeruli count to total glomeruli count ratioSDmale26%unilateral nephrectomy (for 28 days) then spironolactone (5.56 mg/kg/d) (for 28 days)101630unilateral nephrectomy (for 28 days)spironolactone (5.56 mg/kg/d) (for 28 days)
1systolic blood pressureSDmale117mmHgenalapril (5 ml/kg/d) (for 10 days)102814enalapril (5 ml/kg/d) (for 10 days)
5serum creatinine levelSDmale0.3mg/dlleft nephrectomy (for 70 days)103796left nephrectomy (for 70 days)
5creatinine clearanceSDmale1.4ml/minleft nephrectomy (for 70 days)103797left nephrectomy (for 70 days)
8serum immunoglobulin E levelSDnot specified0.1ug/lnaive control condition105406naive control condition
4serum total immunoglobulin E levelSDnot specified0.2ug/lvehicle control condition then acetic acid (for 0 hours) then physical restraint in tube type rodent restrainer (for 2 hours) then fasting (for 1 days)105407vehicle control conditionacetic acid (for 0 hours)physical restraint in tube type rodent restrainer (for 2 hours)fasting (for 1 days)
12serum total immunoglobulin E levelSDnot specified0.1ug/lacetic acid (for 0 hours) then physical restraint in tube type rodent restrainer (for 2 hours) then fasting (for 1 days)105408acetic acid (for 0 hours)physical restraint in tube type rodent restrainer (for 2 hours)fasting (for 1 days)
12serum total immunoglobulin E levelSDnot specified0.28ug/lacetic acid (for 0 hours) then physical restraint in tube type rodent restrainer (for 2 hours) then fasting (for 1 days)105409acetic acid (for 0 hours)physical restraint in tube type rodent restrainer (for 2 hours)fasting (for 1 days)
8serum interleukin-4 levelSDnot specified0.04ug/lnaive control condition105410naive control condition
4serum interleukin-4 levelSDnot specified0.14ug/lvehicle control condition then acetic acid (for 0 hours) then physical restraint in tube type rodent restrainer (for 2 hours) then fasting (for 1 days)105411vehicle control conditionacetic acid (for 0 hours)physical restraint in tube type rodent restrainer (for 2 hours)fasting (for 1 days)
12serum interleukin-4 levelSDnot specified0.05ug/lacetic acid (for 0 hours) then physical restraint in tube type rodent restrainer (for 2 hours) then fasting (for 1 days)105412acetic acid (for 0 hours)physical restraint in tube type rodent restrainer (for 2 hours)fasting (for 1 days)
12serum interleukin-4 levelSDnot specified0.15ug/lacetic acid (for 0 hours) then physical restraint in tube type rodent restrainer (for 2 hours) then fasting (for 1 days)105413acetic acid (for 0 hours)physical restraint in tube type rodent restrainer (for 2 hours)fasting (for 1 days)
8serum interleukin-9 levelSDnot specified0.08ug/lnaive control condition105414naive control condition
4serum interleukin-9 levelSDnot specified0.1ug/lvehicle control condition then acetic acid (for 0 hours) then physical restraint in tube type rodent restrainer (for 2 hours) then fasting (for 1 days)105415vehicle control conditionacetic acid (for 0 hours)physical restraint in tube type rodent restrainer (for 2 hours)fasting (for 1 days)
12serum interleukin-9 levelSDnot specified0.08ug/lacetic acid (for 0 hours) then physical restraint in tube type rodent restrainer (for 2 hours) then fasting (for 1 days)105416acetic acid (for 0 hours)physical restraint in tube type rodent restrainer (for 2 hours)fasting (for 1 days)
12serum interleukin-9 levelSDnot specified0.21ug/lacetic acid (for 0 hours) then physical restraint in tube type rodent restrainer (for 2 hours) then fasting (for 1 days)105417acetic acid (for 0 hours)physical restraint in tube type rodent restrainer (for 2 hours)fasting (for 1 days)
8intestine trypsin levelSDnot specified0.08ug/lnaive control condition105418naive control condition
4intestine trypsin levelSDnot specified0.17ug/lvehicle control condition then acetic acid (for 0 hours) then physical restraint in tube type rodent restrainer (for 2 hours) then fasting (for 1 days)105419vehicle control conditionacetic acid (for 0 hours)physical restraint in tube type rodent restrainer (for 2 hours)fasting (for 1 days)
12intestine trypsin levelSDnot specified0.11ug/lacetic acid (for 0 hours) then physical restraint in tube type rodent restrainer (for 2 hours) then fasting (for 1 days)105420acetic acid (for 0 hours)physical restraint in tube type rodent restrainer (for 2 hours)fasting (for 1 days)
12intestine trypsin levelSDnot specified0.23ug/lacetic acid (for 0 hours) then physical restraint in tube type rodent restrainer (for 2 hours) then fasting (for 1 days)105421acetic acid (for 0 hours)physical restraint in tube type rodent restrainer (for 2 hours)fasting (for 1 days)
6elimination half life of nifedipine in the plasmaSDboth35.52minnifedipine (200 ug/kg) 105706nifedipine (200 ug/kg)
6blood nifedipine levelSDboth926.52ng/mlnifedipine (200 ug/kg) 105708nifedipine (200 ug/kg)
6the first 120min of plasma nifedipine level area under curveSDboth26979.23min x (ng/ml)nifedipine (200 ug/kg) 105710nifedipine (200 ug/kg)
6plasma nifedipine level area under curveSDboth30118.55min x (ng/ml)nifedipine (200 ug/kg) 105712nifedipine (200 ug/kg)
6volume of distribution of nifedipine in the bloodSDboth341.11ml/kgnifedipine (200 ug/kg) 105714nifedipine (200 ug/kg)
6plasma nifedipine clearanceSDboth6.67ml/min/kgnifedipine (200 ug/kg) 105716nifedipine (200 ug/kg)
6nifedipine mean residence timeSDboth38.06minnifedipine (200 ug/kg) 105718nifedipine (200 ug/kg)
10liver weight as percentage of body weightSDfemale3.647%vehicle control condition (5 ml/kg) (for 28 days)105720vehicle control condition (5 ml/kg) (for 28 days)
10liver weight as percentage of body weightSDfemale3.647%2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (3 ng/kg/d) (for 28 days)1057212,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (3 ng/kg/d) (for 28 days)
10liver weight as percentage of body weightSDfemale4.157%2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (22 ng/kg/d) (for 28 days)1057222,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (22 ng/kg/d) (for 28 days)
10liver weight as percentage of body weightSDfemale4.689%2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (100 ng/kg/d) (for 28 days)1057232,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (100 ng/kg/d) (for 28 days)
10liver weight as percentage of body weightSDfemale5.028%2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (300 ng/kg/d) (for 28 days)1057242,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (300 ng/kg/d) (for 28 days)
10liver weight as percentage of body weightSDfemale5.074%2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (1000 ng/kg/d) (for 28 days)1057252,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (1000 ng/kg/d) (for 28 days)
10thymus weight to body weight ratioSDfemale1.5mg/gvehicle control condition (5 ml/kg) (for 28 days)105884vehicle control condition (5 ml/kg) (for 28 days)
10thymus weight to body weight ratioSDfemale1.47mg/g2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (3 ng/kg/d) (for 28 days)1058862,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (3 ng/kg/d) (for 28 days)
10thymus weight to body weight ratioSDfemale1.49mg/g2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (22 ng/kg/d) (for 28 days)1058882,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (22 ng/kg/d) (for 28 days)
10thymus weight to body weight ratioSDfemale1.29mg/g2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (100 ng/kg/d) (for 28 days)1058902,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (100 ng/kg/d) (for 28 days)
10thymus weight to body weight ratioSDfemale1.03mg/g2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (300 ng/kg/d) (for 28 days)1058922,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (300 ng/kg/d) (for 28 days)
10thymus weight to body weight ratioSDfemale0.65mg/g2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (1000 ng/kg/d) (for 28 days)1058942,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (1000 ng/kg/d) (for 28 days)
10spleen weight to body weight ratioSDfemale0.299%vehicle control condition (5 ml/kg) (for 28 days)105896vehicle control condition (5 ml/kg) (for 28 days)
10spleen weight to body weight ratioSDfemale0.287%2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (3 ng/kg/d) (for 28 days)1058982,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (3 ng/kg/d) (for 28 days)
10spleen weight to body weight ratioSDfemale0.28%2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (22 ng/kg/d) (for 28 days)1059002,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (22 ng/kg/d) (for 28 days)
10spleen weight to body weight ratioSDfemale0.278%2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (100 ng/kg/d) (for 28 days)1059022,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (100 ng/kg/d) (for 28 days)
10spleen weight to body weight ratioSDfemale0.278%2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (300 ng/kg/d) (for 28 days)1059042,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (300 ng/kg/d) (for 28 days)
10spleen weight to body weight ratioSDfemale0.265%2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (1000 ng/kg/d) (for 28 days)1059062,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (1000 ng/kg/d) (for 28 days)
10brain weight to body weight ratioSDfemale0.742%vehicle control condition (5 ml/kg) (for 28 days)105908vehicle control condition (5 ml/kg) (for 28 days)
10brain weight to body weight ratioSDfemale0.757%2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (3 ng/kg/d) (for 28 days)1059102,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (3 ng/kg/d) (for 28 days)
10brain weight to body weight ratioSDfemale0.753%2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (22 ng/kg/d) (for 28 days)1059122,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (22 ng/kg/d) (for 28 days)
10brain weight to body weight ratioSDfemale0.768%2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (100 ng/kg/d) (for 28 days)1059142,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (100 ng/kg/d) (for 28 days)
10brain weight to body weight ratioSDfemale0.756%2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (300 ng/kg/d) (for 28 days)1059162,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (300 ng/kg/d) (for 28 days)
10brain weight to body weight ratioSDfemale0.836%2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (1000 ng/kg/d) (for 28 days)1059182,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (1000 ng/kg/d) (for 28 days)
10both ovaries weight to body weight ratioSDfemale0.049%vehicle control condition (5 ml/kg) (for 28 days)105920vehicle control condition (5 ml/kg) (for 28 days)
10both ovaries weight to body weight ratioSDfemale0.046%2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (3 ng/kg/d) (for 28 days)1059222,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (3 ng/kg/d) (for 28 days)
10both ovaries weight to body weight ratioSDfemale0.054%2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (22 ng/kg/d) (for 28 days)1059242,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (22 ng/kg/d) (for 28 days)
10both ovaries weight to body weight ratioSDfemale0.043%2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (100 ng/kg/d) (for 28 days)1059262,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (100 ng/kg/d) (for 28 days)
10both ovaries weight to body weight ratioSDfemale0.041%2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (300 ng/kg/d) (for 28 days)1059282,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (300 ng/kg/d) (for 28 days)
10both ovaries weight to body weight ratioSDfemale0.037%2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (1000 ng/kg/d) (for 28 days)1059302,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (1000 ng/kg/d) (for 28 days)
10red blood cell countSDfemale7.47x 10E6 cells/ulvehicle control condition (5 ml/kg) (for 28 days)105932vehicle control condition (5 ml/kg) (for 28 days)
10red blood cell countSDfemale7.63x 10E6 cells/ul2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (3 ng/kg/d) (for 28 days)1059342,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (3 ng/kg/d) (for 28 days)
10red blood cell countSDfemale7.68x 10E6 cells/ul2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (22 ng/kg/d) (for 28 days)1059362,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (22 ng/kg/d) (for 28 days)
10red blood cell countSDfemale8.02x 10E6 cells/ul2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (100 ng/kg/d) (for 28 days)1059382,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (100 ng/kg/d) (for 28 days)
10red blood cell countSDfemale8.21x 10E6 cells/ul2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (300 ng/kg/d) (for 28 days)1059402,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (300 ng/kg/d) (for 28 days)
10red blood cell countSDfemale9.17x 10E6 cells/ul2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (1000 ng/kg/d) (for 28 days)1059422,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (1000 ng/kg/d) (for 28 days)
10hemoglobin concentrationSDfemale2.17775mmol/lvehicle control condition (5 ml/kg) (for 28 days)105944vehicle control condition (5 ml/kg) (for 28 days)
10hemoglobin concentrationSDfemale2.2165mmol/l2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (3 ng/kg/d) (for 28 days)1059462,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (3 ng/kg/d) (for 28 days)
10hemoglobin concentrationSDfemale2.21185mmol/l2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (22 ng/kg/d) (for 28 days)1059482,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (22 ng/kg/d) (for 28 days)
10hemoglobin concentrationSDfemale2.26145mmol/l2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (100 ng/kg/d) (for 28 days)1059502,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (100 ng/kg/d) (for 28 days)
10hemoglobin concentrationSDfemale2.2754mmol/l2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (300 ng/kg/d) (for 28 days)1059522,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (300 ng/kg/d) (for 28 days)
10hemoglobin concentrationSDfemale2.4428mmol/l2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (1000 ng/kg/d) (for 28 days)1059542,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (1000 ng/kg/d) (for 28 days)
10hematocritSDfemale43.31%vehicle control condition (5 ml/kg) (for 28 days)105956vehicle control condition (5 ml/kg) (for 28 days)
10hematocritSDfemale44.34%2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (3 ng/kg/d) (for 28 days)1059582,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (3 ng/kg/d) (for 28 days)
10hematocritSDfemale44.42%2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (22 ng/kg/d) (for 28 days)1059602,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (22 ng/kg/d) (for 28 days)
10hematocritSDfemale45.1%2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (100 ng/kg/d) (for 28 days)1059622,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (100 ng/kg/d) (for 28 days)
10hematocritSDfemale44.79%2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (300 ng/kg/d) (for 28 days)1059642,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (300 ng/kg/d) (for 28 days)
10hematocritSDfemale48.55%2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (1000 ng/kg/d) (for 28 days)1059662,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (1000 ng/kg/d) (for 28 days)
10mean corpuscular volumeSDfemale57.96flvehicle control condition (5 ml/kg) (for 28 days)105968vehicle control condition (5 ml/kg) (for 28 days)
10mean corpuscular volumeSDfemale58.08fl2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (3 ng/kg/d) (for 28 days)1059702,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (3 ng/kg/d) (for 28 days)
10mean corpuscular volumeSDfemale57.82fl2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (22 ng/kg/d) (for 28 days)1059722,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (22 ng/kg/d) (for 28 days)
10mean corpuscular volumeSDfemale56.27fl2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (100 ng/kg/d) (for 28 days)1059742,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (100 ng/kg/d) (for 28 days)
10mean corpuscular volumeSDfemale54.57fl2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (300 ng/kg/d) (for 28 days)1059762,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (300 ng/kg/d) (for 28 days)
10mean corpuscular volumeSDfemale52.98fl2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (1000 ng/kg/d) (for 28 days)1059782,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (1000 ng/kg/d) (for 28 days)
10mean corpuscular hemoglobin levelSDfemale18.82pgvehicle control condition (5 ml/kg) (for 28 days)105980vehicle control condition (5 ml/kg) (for 28 days)
10mean corpuscular hemoglobin levelSDfemale18.71pg2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (3 ng/kg/d) (for 28 days)1059822,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (3 ng/kg/d) (for 28 days)
10mean corpuscular hemoglobin levelSDfemale18.61pg2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (22 ng/kg/d) (for 28 days)1059842,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (22 ng/kg/d) (for 28 days)
10mean corpuscular hemoglobin levelSDfemale18.19pg2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (100 ng/kg/d) (for 28 days)1059862,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (100 ng/kg/d) (for 28 days)
10mean corpuscular hemoglobin levelSDfemale17.89pg2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (300 ng/kg/d) (for 28 days)1059882,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (300 ng/kg/d) (for 28 days)
10mean corpuscular hemoglobin levelSDfemale17.22pg2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (1000 ng/kg/d) (for 28 days)1059902,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (1000 ng/kg/d) (for 28 days)
10mean corpuscular hemoglobin concentrationSDfemale32.48g/dlvehicle control condition (5 ml/kg) (for 28 days)105992vehicle control condition (5 ml/kg) (for 28 days)
10mean corpuscular hemoglobin concentrationSDfemale32.23g/dl2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (3 ng/kg/d) (for 28 days)1059942,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (3 ng/kg/d) (for 28 days)
10mean corpuscular hemoglobin concentrationSDfemale32.17g/dl2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (22 ng/kg/d) (for 28 days)1059962,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (22 ng/kg/d) (for 28 days)
10mean corpuscular hemoglobin concentrationSDfemale32.37g/dl2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (100 ng/kg/d) (for 28 days)1059982,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (100 ng/kg/d) (for 28 days)
10mean corpuscular hemoglobin concentrationSDfemale32.81g/dl2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (300 ng/kg/d) (for 28 days)1060002,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (300 ng/kg/d) (for 28 days)
10mean corpuscular hemoglobin concentrationSDfemale32.51g/dl2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (1000 ng/kg/d) (for 28 days)1060022,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (1000 ng/kg/d) (for 28 days)
10platelet countSDfemale1308.4x 1000 cells/ulvehicle control condition (5 ml/kg) (for 28 days)106004vehicle control condition (5 ml/kg) (for 28 days)
10platelet countSDfemale1291.9x 1000 cells/ul2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (3 ng/kg/d) (for 28 days)1060062,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (3 ng/kg/d) (for 28 days)
10platelet countSDfemale1299.4x 1000 cells/ul2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (22 ng/kg/d) (for 28 days)1060082,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (22 ng/kg/d) (for 28 days)
10platelet countSDfemale1280.89x 1000 cells/ul2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (100 ng/kg/d) (for 28 days)1060102,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (100 ng/kg/d) (for 28 days)
10platelet countSDfemale1160.6x 1000 cells/ul2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (300 ng/kg/d) (for 28 days)1060122,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (300 ng/kg/d) (for 28 days)
10platelet countSDfemale870.2x 1000 cells/ul2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (1000 ng/kg/d) (for 28 days)1060142,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (1000 ng/kg/d) (for 28 days)
10white blood cell countSDfemale9.42x 1000 cells/ulvehicle control condition (5 ml/kg) (for 28 days)106016vehicle control condition (5 ml/kg) (for 28 days)
10white blood cell countSDfemale10.39x 1000 cells/ul2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (3 ng/kg/d) (for 28 days)1060182,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (3 ng/kg/d) (for 28 days)
10white blood cell countSDfemale9.63x 1000 cells/ul2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (22 ng/kg/d) (for 28 days)1060202,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (22 ng/kg/d) (for 28 days)
10white blood cell countSDfemale9.64x 1000 cells/ul2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (100 ng/kg/d) (for 28 days)1060222,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (100 ng/kg/d) (for 28 days)
10white blood cell countSDfemale10.54x 1000 cells/ul2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (300 ng/kg/d) (for 28 days)1060242,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (300 ng/kg/d) (for 28 days)
10white blood cell countSDfemale8.73x 1000 cells/ul2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (1000 ng/kg/d) (for 28 days)1060262,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (1000 ng/kg/d) (for 28 days)
10blood neutrophil countSDfemale1.48x 1000 cells/ulvehicle control condition (5 ml/kg) (for 28 days)106028vehicle control condition (5 ml/kg) (for 28 days)
10blood neutrophil countSDfemale1.86x 1000 cells/ul2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (3 ng/kg/d) (for 28 days)1060302,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (3 ng/kg/d) (for 28 days)
10blood neutrophil countSDfemale1.38x 1000 cells/ul2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (22 ng/kg/d) (for 28 days)1060322,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (22 ng/kg/d) (for 28 days)
10blood neutrophil countSDfemale1.16x 1000 cells/ul2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (100 ng/kg/d) (for 28 days)1060342,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (100 ng/kg/d) (for 28 days)
10blood neutrophil countSDfemale1.62x 1000 cells/ul2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (300 ng/kg/d) (for 28 days)1060362,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (300 ng/kg/d) (for 28 days)
10blood neutrophil countSDfemale1.08x 1000 cells/ul2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (1000 ng/kg/d) (for 28 days)1060382,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (1000 ng/kg/d) (for 28 days)
10blood lymphocyte countSDfemale7.36x 1000 cells/ulvehicle control condition (5 ml/kg) (for 28 days)106040vehicle control condition (5 ml/kg) (for 28 days)
10blood lymphocyte countSDfemale7.88x 1000 cells/ul2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (3 ng/kg/d) (for 28 days)1060422,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (3 ng/kg/d) (for 28 days)
10blood lymphocyte countSDfemale7.73x 1000 cells/ul2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (22 ng/kg/d) (for 28 days)1060442,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (22 ng/kg/d) (for 28 days)
10blood lymphocyte countSDfemale7.97x 1000 cells/ul2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (100 ng/kg/d) (for 28 days)1060462,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (100 ng/kg/d) (for 28 days)
10blood lymphocyte countSDfemale8.36x 1000 cells/ul2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (300 ng/kg/d) (for 28 days)1060482,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (300 ng/kg/d) (for 28 days)
10blood lymphocyte countSDfemale7.18x 1000 cells/ul2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (1000 ng/kg/d) (for 28 days)1060502,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (1000 ng/kg/d) (for 28 days)
10blood monocyte countSDfemale0.29x 1000 cells/ulvehicle control condition (5 ml/kg) (for 28 days)106052vehicle control condition (5 ml/kg) (for 28 days)
10blood monocyte countSDfemale0.33x 1000 cells/ul2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (3 ng/kg/d) (for 28 days)1060542,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (3 ng/kg/d) (for 28 days)
10blood monocyte countSDfemale0.29x 1000 cells/ul2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (22 ng/kg/d) (for 28 days)1060562,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (22 ng/kg/d) (for 28 days)
10blood monocyte countSDfemale0.27x 1000 cells/ul2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (100 ng/kg/d) (for 28 days)1060582,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (100 ng/kg/d) (for 28 days)
10blood monocyte countSDfemale0.32x 1000 cells/ul2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (300 ng/kg/d) (for 28 days)1060602,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (300 ng/kg/d) (for 28 days)
10blood monocyte countSDfemale0.24x 1000 cells/ul2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (1000 ng/kg/d) (for 28 days)1060622,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (1000 ng/kg/d) (for 28 days)
10blood eosinophil countSDfemale0.13x 1000 cells/ulvehicle control condition (5 ml/kg) (for 28 days)106064vehicle control condition (5 ml/kg) (for 28 days)
10blood eosinophil countSDfemale0.16x 1000 cells/ul2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (3 ng/kg/d) (for 28 days)1060662,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (3 ng/kg/d) (for 28 days)
10blood eosinophil countSDfemale0.08x 1000 cells/ul2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (22 ng/kg/d) (for 28 days)1060682,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (22 ng/kg/d) (for 28 days)
10blood eosinophil countSDfemale0.07x 1000 cells/ul2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (100 ng/kg/d) (for 28 days)1060702,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (100 ng/kg/d) (for 28 days)
10blood eosinophil countSDfemale0.04x 1000 cells/ul2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (300 ng/kg/d) (for 28 days)1060722,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (300 ng/kg/d) (for 28 days)
10blood eosinophil countSDfemale0.04x 1000 cells/ul2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (1000 ng/kg/d) (for 28 days)1060742,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (1000 ng/kg/d) (for 28 days)
10blood basophil countSDfemale0.07x 1000 cells/ulvehicle control condition (5 ml/kg) (for 28 days)106076vehicle control condition (5 ml/kg) (for 28 days)
10blood basophil countSDfemale0.08x 1000 cells/ul2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (3 ng/kg/d) (for 28 days)1060782,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (3 ng/kg/d) (for 28 days)
10blood basophil countSDfemale0.08x 1000 cells/ul2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (22 ng/kg/d) (for 28 days)1060802,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (22 ng/kg/d) (for 28 days)
10blood basophil countSDfemale0.08x 1000 cells/ul2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (100 ng/kg/d) (for 28 days)1060822,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (100 ng/kg/d) (for 28 days)
10blood basophil countSDfemale0.1x 1000 cells/ul2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (300 ng/kg/d) (for 28 days)1060842,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (300 ng/kg/d) (for 28 days)
10blood basophil countSDfemale0.08x 1000 cells/ul2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (1000 ng/kg/d) (for 28 days)1060862,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (1000 ng/kg/d) (for 28 days)
3verapamil apparent influx permeability clearance in retina barrierSDmale0.824ml/min/gtritiated verapamil (10 uCi) (for 0 hours)106102tritiated verapamil (10 uCi) (for 0 hours)
3verapamil apparent influx permeability clearance in aqueous humorSDmale0.0022ml/min/gtritiated verapamil (10 uCi) (for 0 hours)106103tritiated verapamil (10 uCi) (for 0 hours)
3verapamil equilibrated distribution volume in retinaSDmale3.32ml/gtritiated verapamil (10 uCi) (for 0 hours)106108tritiated verapamil (10 uCi) (for 0 hours)
3verapamil equilibrated distribution volume in aqueous humorSDmale0.0728ml/gtritiated verapamil (10 uCi) (for 0 hours)106109tritiated verapamil (10 uCi) (for 0 hours)
3verapamil equilibrated distribution volume in brainSDmale0.542ml/gtritiated verapamil (10 uCi) (for 0 hours)106110tritiated verapamil (10 uCi) (for 0 hours)
3quinidine uptake index in retinaSDmale212%tritiated quinidine (10 uCi) (for 0 hours) and vehicle control condition (for 0 hours)106114tritiated quinidine (10 uCi) (for 0 hours)vehicle control condition (for 0 hours)
3quinidine uptake index in retinaSDmale187%tritiated quinidine (10 uCi) (for 0 hours) and quinidine (10 mmol/l) (for 0 hours)106115tritiated quinidine (10 uCi) (for 0 hours)quinidine (10 mmol/l) (for 0 hours)
3quinidine uptake index in retinaSDmale180%tritiated quinidine (10 uCi) (for 0 hours) and verapamil (3 mmol/l) (for 0 hours)106116tritiated quinidine (10 uCi) (for 0 hours)verapamil (3 mmol/l) (for 0 hours)
3digoxin uptake index in retinaSDmale24%tritiated digoxin (10 uCi) (for 0 hours) and vehicle control condition (for 0 hours)106117tritiated digoxin (10 uCi) (for 0 hours)vehicle control condition (for 0 hours)
3digoxin uptake index in retinaSDmale26.3%tritiated digoxin (10 uCi) (for 0 hours) and digoxin (0.01 mmol/l) (for 0 hours)106118tritiated digoxin (10 uCi) (for 0 hours)digoxin (0.01 mmol/l) (for 0 hours)
3digoxin uptake index in retinaSDmale27.9%tritiated digoxin (10 uCi) (for 0 hours) and verapamil (3 mmol/l) (for 0 hours)106119tritiated digoxin (10 uCi) (for 0 hours)verapamil (3 mmol/l) (for 0 hours)
3verapamil uptake index in retinaSDmale336%tritiated verapamil (10 uCi) (for 0 hours) and vehicle control condition (for 0 hours)106120tritiated verapamil (10 uCi) (for 0 hours)vehicle control condition (for 0 hours)
3verapamil uptake index in retinaSDmale327%tritiated verapamil (10 uCi) (for 0 hours) and vinblastine (1 mmol/l) (for 0 hours)106121tritiated verapamil (10 uCi) (for 0 hours)vinblastine (1 mmol/l) (for 0 hours)
3verapamil uptake index in retinaSDmale439%tritiated verapamil (10 uCi) (for 0 hours) and verapamil (3 mmol/l) (for 0 hours)106122tritiated verapamil (10 uCi) (for 0 hours)verapamil (3 mmol/l) (for 0 hours)
3quinidine uptake index in aqueous humorSDmale5.95%tritiated quinidine (10 uCi) (for 0 hours) and vehicle control condition (for 0 hours)106132tritiated quinidine (10 uCi) (for 0 hours)vehicle control condition (for 0 hours)
3quinidine uptake index in aqueous humorSDmale11.7%tritiated quinidine (10 uCi) (for 0 hours) and quinidine (10 mmol/l) (for 0 hours)106133tritiated quinidine (10 uCi) (for 0 hours)quinidine (10 mmol/l) (for 0 hours)
3quinidine uptake index in aqueous humorSDmale14.2%tritiated quinidine (10 uCi) (for 0 hours) and verapamil (3 mmol/l) (for 0 hours)106134tritiated quinidine (10 uCi) (for 0 hours)verapamil (3 mmol/l) (for 0 hours)
3digoxin uptake index in aqueous humorSDmale17.5%tritiated quinidine (10 uCi) (for 0 hours) and verapamil (3 mmol/l) (for 0 hours)106135tritiated quinidine (10 uCi) (for 0 hours)verapamil (3 mmol/l) (for 0 hours)
3digoxin uptake index in aqueous humorSDmale15.8%tritiated digoxin (10 uCi) (for 0 hours) and digoxin (0.01 mmol/l) (for 0 hours)106136tritiated digoxin (10 uCi) (for 0 hours)digoxin (0.01 mmol/l) (for 0 hours)
3digoxin uptake index in aqueous humorSDmale9.48%tritiated digoxin (10 uCi) (for 0 hours) and verapamil (3 mmol/l) (for 0 hours)106137tritiated digoxin (10 uCi) (for 0 hours)verapamil (3 mmol/l) (for 0 hours)
3verapamil uptake index in aqueous humorSDmale8.46%tritiated verapamil (10 uCi) (for 0 hours) and vehicle control condition (for 0 hours)106138tritiated verapamil (10 uCi) (for 0 hours)vehicle control condition (for 0 hours)
3verapamil uptake index in aqueous humorSDmale15.7%tritiated verapamil (10 uCi) (for 0 hours) and vinblastine (1 mmol/l) (for 0 hours)106139tritiated verapamil (10 uCi) (for 0 hours)vinblastine (1 mmol/l) (for 0 hours)
3verapamil uptake index in aqueous humorSDmale23.1%tritiated verapamil (10 uCi) (for 0 hours) and verapamil (3 mmol/l) (for 0 hours)106140tritiated verapamil (10 uCi) (for 0 hours)verapamil (3 mmol/l) (for 0 hours)
3quinidine uptake index in brainSDmale2.12%tritiated quinidine (10 uCi) (for 0 hours) and vehicle control condition (for 0 hours)106150tritiated quinidine (10 uCi) (for 0 hours)vehicle control condition (for 0 hours)
3quinidine uptake index in brainSDmale18.2%tritiated quinidine (10 uCi) (for 0 hours) and quinidine (10 mmol/l) (for 0 hours)106151tritiated quinidine (10 uCi) (for 0 hours)quinidine (10 mmol/l) (for 0 hours)
3quinidine uptake index in brainSDmale13.2%tritiated quinidine (10 uCi) (for 0 hours) and verapamil (3 mmol/l) (for 0 hours)106152tritiated quinidine (10 uCi) (for 0 hours)verapamil (3 mmol/l) (for 0 hours)
3digoxin uptake index in brainSDmale0.987%tritiated digoxin (10 uCi) (for 0 hours) and vehicle control condition (for 0 hours)106153tritiated digoxin (10 uCi) (for 0 hours)vehicle control condition (for 0 hours)
3digoxin uptake index in brainSDmale1.18%tritiated digoxin (10 uCi) (for 0 hours) and digoxin (0.01 mmol/l) (for 0 hours)106154tritiated digoxin (10 uCi) (for 0 hours)digoxin (0.01 mmol/l) (for 0 hours)
3digoxin uptake index in brainSDmale0.96%tritiated digoxin (10 uCi) (for 0 hours) and verapamil (3 mmol/l) (for 0 hours)106155tritiated digoxin (10 uCi) (for 0 hours)verapamil (3 mmol/l) (for 0 hours)
3verapamil uptake index in brainSDmale9.07%tritiated verapamil (10 uCi) (for 0 hours) and vehicle control condition (for 0 hours)106156tritiated verapamil (10 uCi) (for 0 hours)vehicle control condition (for 0 hours)
3verapamil uptake index in brainSDmale42.5%tritiated verapamil (10 uCi) (for 0 hours) and vinblastine (1 mmol/l) (for 0 hours)106157tritiated verapamil (10 uCi) (for 0 hours)vinblastine (1 mmol/l) (for 0 hours)
3verapamil uptake index in brainSDmale77.7%tritiated verapamil (10 uCi) (for 0 hours) and verapamil (3 mmol/l) (for 0 hours)106158tritiated verapamil (10 uCi) (for 0 hours)verapamil (3 mmol/l) (for 0 hours)
5serum alanine aminotransferase activity levelSDmale56.6U/lnaive control condition (for 84 days)106362naive control condition (for 84 days)
5serum alanine aminotransferase activity levelSDfemale65U/lnaive control condition (for 84 days)106364naive control condition (for 84 days)
5serum aspartate aminotransferase activity levelSDmale156.2U/lnaive control condition (for 84 days)106366naive control condition (for 84 days)
5serum aspartate aminotransferase activity levelSDfemale134.2U/lnaive control condition (for 84 days)106368naive control condition (for 84 days)
5serum alkaline phosphatase activity levelSDmale74.6U/lnaive control condition (for 84 days)106370naive control condition (for 84 days)
5serum alkaline phosphatase activity levelSDfemale77U/lnaive control condition (for 84 days)106372naive control condition (for 84 days)
5total serum bilirubin levelSDmale0.05mg/dlnaive control condition (for 84 days)106374naive control condition (for 84 days)
5total serum bilirubin levelSDfemale0.05mg/dlnaive control condition (for 84 days)106376naive control condition (for 84 days)
5serum total protein levelSDmale70g/dlnaive control condition (for 84 days)106382naive control condition (for 84 days)
5serum total protein levelSDfemale67g/dlnaive control condition (for 84 days)106384naive control condition (for 84 days)
5serum albumin levelSDmale4.5g/dlnaive control condition (for 84 days)106386naive control condition (for 84 days)
5serum albumin levelSDfemale4.5g/dlnaive control condition (for 84 days)106388naive control condition (for 84 days)
5serum globulin levelSDmale2.5g/dlnaive control condition (for 84 days)106390naive control condition (for 84 days)
5serum globulin levelSDfemale2.2g/dlnaive control condition (for 84 days)106392naive control condition (for 84 days)
5blood albumin level to blood globulin level ratioSDmale1.8naive control condition (for 84 days)106394naive control condition (for 84 days)
5blood albumin level to blood globulin level ratioSDfemale2.1naive control condition (for 84 days)106396naive control condition (for 84 days)
5serum total cholesterol levelSDmale113.8mg/dlnaive control condition (for 84 days)106398naive control condition (for 84 days)
5serum total cholesterol levelSDfemale106.8mg/dlnaive control condition (for 84 days)106400naive control condition (for 84 days)
5serum triglyceride levelSDmale156.8mg/dlnaive control condition (for 84 days)106402naive control condition (for 84 days)
5serum triglyceride levelSDfemale130.4mg/dlnaive control condition (for 84 days)106404naive control condition (for 84 days)
5serum urea nitrogen levelSDmale22.4mg/dlnaive control condition (for 84 days)106406naive control condition (for 84 days)
5serum urea nitrogen levelSDfemale24.6mg/dlnaive control condition (for 84 days)106408naive control condition (for 84 days)
5serum creatinine levelSDmale0.3mg/dlnaive control condition (for 84 days)106410naive control condition (for 84 days)
5serum creatinine levelSDfemale0.34mg/dlnaive control condition (for 84 days)106412naive control condition (for 84 days)
5serum glucose levelSDmale285mg/dlnaive control condition (for 84 days)106414naive control condition (for 84 days)
5serum glucose levelSDfemale311.2mg/dlnaive control condition (for 84 days)106416naive control condition (for 84 days)
5serum sodium levelSDmale149.4mmol/lnaive control condition (for 84 days)106418naive control condition (for 84 days)
5serum sodium levelSDfemale149mmol/lnaive control condition (for 84 days)106420naive control condition (for 84 days)
5serum chloride levelSDmale100.2mmol/lnaive control condition (for 84 days)106426naive control condition (for 84 days)
5serum chloride levelSDfemale100.4mmol/lnaive control condition (for 84 days)106428naive control condition (for 84 days)
5serum calcium levelSDmale13.2mg/dlnaive control condition (for 84 days)106430naive control condition (for 84 days)
5serum calcium levelSDfemale13.9mg/dlnaive control condition (for 84 days)106432naive control condition (for 84 days)
5serum phosphate levelSDmale12.3mg/dlnaive control condition (for 84 days)106434naive control condition (for 84 days)
5serum phosphate levelSDfemale12.6mg/dlnaive control condition (for 84 days)106436naive control condition (for 84 days)
5body weightSDmale386.2gnaive control condition (for 84 days)106438naive control condition (for 84 days)
5body weightSDfemale257.6gnaive control condition (for 84 days)106440naive control condition (for 84 days)
5liver weightSDmale4.61gnaive control condition (for 84 days)106442naive control condition (for 84 days)
5liver weightSDfemale4.35gnaive control condition (for 84 days)106444naive control condition (for 84 days)
5kidney weightSDmale0.88gnaive control condition (for 84 days)106446naive control condition (for 84 days)
5kidney weightSDfemale0.81gnaive control condition (for 84 days)106448naive control condition (for 84 days)
5heart weightSDmale0.38gnaive control condition (for 84 days)106450naive control condition (for 84 days)
5heart weightSDfemale0.39gnaive control condition (for 84 days)106452naive control condition (for 84 days)
5pancreas weightSDmale280mgnaive control condition (for 84 days)106454naive control condition (for 84 days)
5pancreas weightSDfemale390mgnaive control condition (for 84 days)106456naive control condition (for 84 days)
5spleen weightSDmale0.25gnaive control condition (for 84 days)106458naive control condition (for 84 days)
5spleen weightSDfemale0.3gnaive control condition (for 84 days)106460naive control condition (for 84 days)
5thymus weightSDmale0.16gnaive control condition (for 84 days)106462naive control condition (for 84 days)
5thymus weightSDfemale0.15gnaive control condition (for 84 days)106464naive control condition (for 84 days)
5brain weightSDmale0.48gnaive control condition (for 84 days)106466naive control condition (for 84 days)
5brain weightSDfemale0.67gnaive control condition (for 84 days)106468naive control condition (for 84 days)
5lung weightSDmale0.59gnaive control condition (for 84 days)106470naive control condition (for 84 days)
5lung weightSDfemale0.73gnaive control condition (for 84 days)106472naive control condition (for 84 days)
5thyroid gland weightSDmale0.006gnaive control condition (for 84 days)106474naive control condition (for 84 days)
5thyroid gland weightSDfemale0.008gnaive control condition (for 84 days)106476naive control condition (for 84 days)
5adrenal gland weightSDmale13mgnaive control condition (for 84 days)106478naive control condition (for 84 days)
5adrenal gland weightSDfemale26mgnaive control condition (for 84 days)106480naive control condition (for 84 days)
5pituitary gland weightSDmale0.004gnaive control condition (for 84 days)106482naive control condition (for 84 days)
5pituitary gland weightSDfemale0.006gnaive control condition (for 84 days)106484naive control condition (for 84 days)
12both ovaries weightSDfemale0.048gnaive control condition (for 84 days)106486naive control condition (for 84 days)
12both testes wet weightSDmale0.99gnaive control condition (for 84 days)106488naive control condition (for 84 days)
12epididymides weightSDmale0.56gnaive control condition (for 84 days)106490naive control condition (for 84 days)
12prostate gland weightSDmale0.25gnaive control condition (for 84 days)106492naive control condition (for 84 days)