LEW/Crl |
acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70 days-84 days |
24 |
73.54 |
% |
3.22 |
15.75 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan |
55383 |
522 |
LEW/Crl |
dose of methacholine at which pulmonary conductance is half its pretreatment value |
controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) |
PhysGen Lung data |
pulmonary ventilation trait |
male |
77 days-91 days |
8 |
9.07 |
mg/kg |
1.3 |
3.68 |
stop flow air displacement plethysmography |
|
0 |
|
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan |
57769 |
526 |
LEW/Crl |
concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
male |
70 days-84 days |
24 |
0.05 |
umol/l |
0.01 |
0.03 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan |
57431 |
522 |
LEW/Crl |
logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70 days-84 days |
24 |
-7.17 |
null |
0.06 |
0.32 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan |
54744 |
522 |
LEW/Crl |
logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70 days-84 days |
24 |
-6.98 |
null |
0.07 |
0.34 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan |
54749 |
522 |
LEW/Crl |
logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) |
phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70 days-84 days |
23 |
-7.2 |
null |
0.06 |
0.27 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan |
56773 |
522 |
LEW/Crl |
concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) |
phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
female |
70 days-84 days |
23 |
0.05 |
umol/l |
0.0 |
0.02 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan |
56998 |
522 |
LEW/Crl |
sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70 days-84 days |
20 |
99.35 |
% |
0.36 |
1.63 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan |
57122 |
522 |
LEW/Crl |
concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) |
phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70 days-84 days |
22 |
0.97 |
E-7mole |
0.13 |
0.6 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan |
56802 |
522 |
LEW/Crl |
logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) |
phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
female |
70 days-84 days |
23 |
-7.37 |
null |
0.05 |
0.23 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
EC50 value is moles/liter |
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan |
56816 |
522 |
LEW/Crl |
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70 days-84 days |
21 |
-8.82 |
null |
0.1 |
0.47 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan |
55117 |
522 |
LEW/Crl |
acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70 days-84 days |
23 |
71.74 |
% |
3.99 |
19.12 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan |
56753 |
522 |
LEW/Crl |
concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70 days-84 days |
21 |
0.02 |
10E-7mol/l |
0.0 |
0.02 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan |
56768 |
522 |
LEW/Crl |
dose of methacholine at which pulmonary conductance is half its pretreatment value |
methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) |
PhysGen Lung data |
pulmonary ventilation trait |
male |
77 days-91 days |
7 |
3.48 |
mg/kg |
0.53 |
1.39 |
stop flow air displacement plethysmography |
|
0 |
|
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan |
60112 |
526 |
LEW/Crl |
concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) |
phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
male |
70 days-84 days |
24 |
0.06 |
umol/l |
0.01 |
0.04 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan |
57003 |
522 |
LEW/Crl |
logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) |
phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70 days-84 days |
22 |
-7.09 |
null |
0.06 |
0.28 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan |
56778 |
522 |
LEW/Crl |
concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) |
phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70 days-84 days |
23 |
0.78 |
E-7mole |
0.14 |
0.66 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan |
56797 |
522 |
LEW/Crl |
concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70 days-84 days |
24 |
0.86 |
E-7mole |
0.12 |
0.57 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan |
55979 |
522 |
LEW/Crl |
concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) |
phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70 days-84 days |
21 |
0.03 |
10E-7mol/l |
0.01 |
0.04 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan |
56453 |
522 |
LEW/Crl |
acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70 days-84 days |
24 |
72.71 |
% |
3.92 |
19.21 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan |
55388 |
522 |
LEW/Crl |
logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
female |
70 days-84 days |
25 |
-7.5 |
null |
0.08 |
0.37 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
EC50 value is moles/liter |
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan |
56735 |
522 |
LEW/Crl |
logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
male |
70 days-84 days |
24 |
-7.4 |
null |
0.06 |
0.29 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
EC50 value is moles/liter |
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan |
56740 |
522 |
LEW/Crl |
concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70 days-84 days |
23 |
0.01 |
10E-7mol/l |
0.0 |
0.01 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan |
56763 |
522 |
LEW/Crl |
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) |
phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70 days-84 days |
21 |
-8.69 |
null |
0.08 |
0.36 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan |
55345 |
522 |
LEW/Crl |
concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
female |
70 days-84 days |
25 |
0.04 |
umol/l |
0.01 |
0.03 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan |
57426 |
522 |
LEW/Crl |
dose of methacholine at which pulmonary conductance is half its pretreatment value |
controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) |
PhysGen Lung data |
pulmonary ventilation trait |
female |
77 days-91 days |
9 |
5.59 |
mg/kg |
1.03 |
3.1 |
stop flow air displacement plethysmography |
|
0 |
|
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan |
57764 |
526 |
LEW/Crl |
sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70 days-84 days |
22 |
96.0 |
% |
3.12 |
14.64 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan |
56857 |
522 |
LEW/Crl |
acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70 days-84 days |
23 |
77.26 |
% |
2.08 |
9.99 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan |
56748 |
522 |
LEW/Crl |
logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) |
phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
male |
70 days-84 days |
24 |
-7.29 |
null |
0.06 |
0.28 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
EC50 value is moles/liter |
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan |
56821 |
522 |
LEW/Crl |
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) |
phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70 days-84 days |
20 |
-8.57 |
null |
0.08 |
0.37 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan |
55350 |
522 |
LEW/Crl |
concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70 days-84 days |
24 |
1.43 |
E-7mole |
0.27 |
1.32 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan |
55984 |
522 |
LEW/Crl |
concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) |
phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70 days-84 days |
20 |
0.04 |
10E-7mol/l |
0.01 |
0.03 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan |
56458 |
522 |
LEW/Crl |
dose of methacholine at which pulmonary conductance is half its pretreatment value |
methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) |
PhysGen Lung data |
pulmonary ventilation trait |
female |
77 days-91 days |
9 |
2.47 |
mg/kg |
0.7 |
2.1 |
stop flow air displacement plethysmography |
|
0 |
|
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan |
60107 |
526 |
LEW/Crl |
sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70 days-84 days |
21 |
99.29 |
% |
0.32 |
1.45 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan |
57117 |
522 |
LEW/Crl |
sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70 days-84 days |
23 |
99.43 |
% |
0.27 |
1.31 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan |
56852 |
522 |
LEW/Crl |
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70 days-84 days |
23 |
-9.04 |
null |
0.06 |
0.29 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan |
55112 |
522 |