Phenominer Database Results (186 results)

 
 
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Strain Phenotype Conditions Study Experiment Name Sex Age # of Animals Formula Value Units SEM SD Method Method Duration Post Insult Time Value Method Notes Clinical Measurement Notes Experiment Notes Record ID Study ID
FHH-Chr YBN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 21 0.26 ml 0.01 0.05 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15246 381
FHH-Chr YBN/Mcwi percent change in respiration rate controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 21 146.37 % 5.65 25.89 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54235 381
FHH-Chr YBN/Mcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 21 0.26 ml 0.01 0.04 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 17995 381
FHH-Chr YBN/Mcwi respiration rate control condition PhysGen Respiratory data respiratory function trait male 82 days-99 days 21 109.31 breaths/min 3.18 14.57 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18423 381
FHH-Chr YBN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 80.04 mmHg 7.8 24.65 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49901 461
FHH-Chr YBN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 11 1262.09 s 28.21 93.58 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50240 461
FHH-Chr YBN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 9 17.78 mmol/l 0.68 2.05 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42075 401
FHH-Chr YBN/Mcwi blood neutrophil count control condition (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77 days-91 days 9 0.95 x 1000 cells/ul 0.12 0.35 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38941 401
FHH-Chr YBN/Mcwi plasma creatinine level control condition (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 9 0.18 mg/dl 0.01 0.04 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 42691 401
FHH-Chr YBN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 9 7.5 x 1000 cells/ul 0.32 0.96 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40939 401
FHH-Chr YBN/Mcwi lung dry weight to body weight ratio control condition (for 14 days) PhysGen Lung data lung mass male 77 days-91 days 17 1.15 g/kg 0.03 0.13 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59499 526
FHH-Chr YBN/Mcwi serum total cholesterol level control condition (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 9 94.78 mg/dl 2.16 6.48 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38478 401
FHH-Chr YBN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 9 0.11 mg/dl 0.01 0.03 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41881 401
FHH-Chr YBN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 14 0.65 g 0.02 0.09 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45418 461
FHH-Chr YBN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 11 88.88 mmHg 5.76 19.11 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48637 461
FHH-Chr YBN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 19 -7.79 null 0.07 0.28 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 55311 522
FHH-Chr YBN/Mcwi tidal volume controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 21 0.37 ml 0.02 0.07 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16486 381
FHH-Chr YBN/Mcwi heart right ventricle weight to left ventricle weight ratio control condition (for 14 days) PhysGen Lung data heart right ventricle mass male 77 days-91 days 17 0.28 null 0.01 0.04 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 57946 526
FHH-Chr YBN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 19 1.12 E-7mole 0.28 1.21 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55930 522
FHH-Chr YBN/Mcwi body weight control condition (for 14 days) PhysGen Lung data body mass male 77 days-91 days 17 132.6 g 4.9 20.2 whole body digital scale 0 Moms and pups used in studies were fed Teklad 58383 526
FHH-Chr YBN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 11 -7.01 null 0.09 0.28 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56951 522
FHH-Chr YBN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 9 0.61 IU/g 0.11 0.34 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47343 461
FHH-Chr YBN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 80.78 % 6.67 21.09 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48308 461
FHH-Chr YBN/Mcwi left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 5.48 mmHg 0.07 0.23 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49190 461
FHH-Chr YBN/Mcwi percent change in tidal volume controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 21 143.3 % 4.66 21.34 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54101 381
FHH-Chr YBN/Mcwi percent change in ventilation controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 21 %change=VE during7-9 min hypercapnia/control during standard conditions 216.73 % 11.9 54.54 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14211 381
FHH-Chr YBN/Mcwi urine potassium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine potassium amount male 80 days-99 days 5 1.47 mEq/d 0.06 0.14 flame atomic emission spectrometry 0 urine potassium analysis Moms were fed Teklad, pups used in studies were fed Dyets 52317 482
FHH-Chr YBN/Mcwi creatinine clearance controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data glomerular filtration trait male 80 days-99 days 4 1.34 ml/min 0.09 0.18 urine creatinine analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52364 482
FHH-Chr YBN/Mcwi heart rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data heart pumping trait male 80 days-99 days 4 410.74 beats/min 18.25 36.49 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52509 482
FHH-Chr YBN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 11 10.86 ml/min/g 1.0 3.33 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46666 461
FHH-Chr YBN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 10 17.9 IU/g 2.2 6.96 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45992 461
FHH-Chr YBN/Mcwi serum chloride level control condition (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 9 103.22 mmol/l 0.57 1.72 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40051 401
FHH-Chr YBN/Mcwi methylene blue metabolism-surface area product without auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 13 19.35 ml/min/kg 2.28 8.24 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58668 526
FHH-Chr YBN/Mcwi serum albumin level control condition (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 9 3.52 g/dl 0.07 0.22 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40452 401
FHH-Chr YBN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 84.57 % 7.99 25.28 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48769 461
FHH-Chr YBN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 9 13.41 ml/min/kg 0.55 1.65 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57611 526
FHH-Chr YBN/Mcwi serum phosphate level control condition (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 9 10.72 mg/dl 0.33 0.99 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37872 401
FHH-Chr YBN/Mcwi urine total protein excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data total urine protein amount male 80 days-99 days 5 343.25 mg/d 120.66 269.8 automated urine total protein analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52119 482
FHH-Chr YBN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount male 80 days-99 days 4 0.44 mg/dl 0.03 0.06 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52268 482
FHH-Chr YBN/Mcwi respiration rate controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 21 151.57 breaths/min 2.98 13.66 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16924 381
FHH-Chr YBN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 9 437.11 U/l 13.39 40.17 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36392 401
FHH-Chr YBN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 9 5.24 g/dl 0.06 0.18 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36975 401
FHH-Chr YBN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 9 70.22 mg/dl 2.0 6.0 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37110 401
FHH-Chr YBN/Mcwi percent change in ventilation controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 21 %change=VE during7-9 min hypercapnia/control during standard conditions 121.54 % 6.25 28.62 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18556 381
FHH-Chr YBN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 21 142.33 breaths/min 6.05 27.74 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18278 381
FHH-Chr YBN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 21 0.16 degrees C 0.12 0.53 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20322 381
FHH-Chr YBN/Mcwi heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 9 198.21 beats/min 8.72 26.16 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48958 461
FHH-Chr YBN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 10 11.25 % 2.37 7.49 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49409 461
FHH-Chr YBN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 11 21.91 mmHg 2.06 6.85 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50010 461
FHH-Chr YBN/Mcwi serum total bilirubin level control condition (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 9 0.11 mg/dl 0.01 0.04 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42928 401
FHH-Chr YBN/Mcwi serum potassium level control condition (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 8 4.72 mmol/l 0.36 1.01 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 43372 401
FHH-Chr YBN/Mcwi blood monocyte count control condition (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 9 0.22 x 1000 cells/ul 0.04 0.11 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40339 401
FHH-Chr YBN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 9 1.47 g/dl 0.03 0.1 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40563 401
FHH-Chr YBN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 9 18.32 g/dl 0.27 0.8 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 37981 401
FHH-Chr YBN/Mcwi hematocrit control condition (for 14 days) PhysGen Lung data erythrocyte quantity male 77 days-91 days 9 38.59 % 0.91 2.74 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 57532 526
FHH-Chr YBN/Mcwi body weight controlled sodium content diet (4 %) (for 21 days) PhysGen Vascular data body mass male 70 days-84 days 11 217.6 g 13.3 44.2 whole body digital scale 0 Moms and pups used in studies were fed Teklad 55215 522
FHH-Chr YBN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 9 21.13 ml/min/kg 1.45 4.36 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57813 526
FHH-Chr YBN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 19 -7.09 null 0.07 0.32 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55661 522
FHH-Chr YBN/Mcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 21 28.22 ml/min 1.04 4.79 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16703 381
FHH-Chr YBN/Mcwi body temperature control condition PhysGen Respiratory data body temperature trait male 82 days-99 days 21 36.35 degrees C 0.62 2.84 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16825 381
FHH-Chr YBN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass male 77 days-91 days 14 0.54 null 0.02 0.08 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58746 526
FHH-Chr YBN/Mcwi left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 98.64 mmHg 3.88 11.63 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 44828 461
FHH-Chr YBN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 37.42 mmHg 5.25 16.61 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45283 461
FHH-Chr YBN/Mcwi minute ventilation controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 21 55.78 ml/min 2.29 10.51 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20774 381
FHH-Chr YBN/Mcwi body weight control condition PhysGen Respiratory data body mass male 82 days-99 days 21 237.4 g 5.6 25.8 whole body digital scale 0 Moms and pups used in studies were fed Dyets 17830 381
FHH-Chr YBN/Mcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 21 0.26 ml 0.01 0.05 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15410 381
FHH-Chr YBN/Mcwi minute ventilation controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 21 56.35 ml/min 2.53 11.61 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14513 381
FHH-Chr YBN/Mcwi body temperature controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 21 36.8 degrees C 0.15 0.68 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 13572 381
FHH-Chr YBN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 21 37.43 ml/min 1.41 6.46 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18675 381
FHH-Chr YBN/Mcwi serum sodium level control condition (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 9 141.33 mmol/l 0.53 1.58 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36535 401
FHH-Chr YBN/Mcwi percent change in left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 118.99 % 6.77 20.32 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 44931 461
FHH-Chr YBN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 9 0.39 null 0.02 0.06 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58126 526
FHH-Chr YBN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77 days-91 days 9 0.07 x 1000 cells/ul 0.02 0.06 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41660 401
FHH-Chr YBN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 9 32.12 g/dl 0.25 0.74 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39790 401
FHH-Chr YBN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount male 77 days-91 days 9 138.78 mg/dl 3.58 10.73 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38543 401
FHH-Chr YBN/Mcwi mean corpuscular volume control condition (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 9 53.53 fl 0.27 0.81 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38692 401
FHH-Chr YBN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 9 68.78 U/l 7.69 23.06 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40727 401
FHH-Chr YBN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77 days-91 days 9 57.14 % 0.74 2.23 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59270 526
FHH-Chr YBN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 9 57.14 % 0.74 2.23 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39004 401
FHH-Chr YBN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77 days-91 days 9 23.56 mg/dl 1.48 4.45 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40841 401
FHH-Chr YBN/Mcwi serum alanine aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 9 79.78 U/l 3.39 10.16 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37752 401
FHH-Chr YBN/Mcwi body weight control condition (for 21 days) PhysGen Vascular data body mass male 70 days-84 days 19 193.4 g 6.5 28.4 whole body digital scale 0 Moms and pups used in studies were fed Teklad 55450 522
FHH-Chr YBN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data renin activity male 80 days-99 days 4 2.47 ng/ml/h 0.64 1.27 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52903 482
FHH-Chr YBN/Mcwi serum total protein level control condition (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 9 4.79 g/dl 0.1 0.31 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37243 401
FHH-Chr YBN/Mcwi serum calcium level control condition (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 9 9.49 mg/dl 0.08 0.25 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36804 401
FHH-Chr YBN/Mcwi time to onset of heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 10 950.9 s 36.15 114.31 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50132 461
FHH-Chr YBN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 9 59.94 fl 0.28 0.84 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38758 401
FHH-Chr YBN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 9 9.53 x 10E6 cells/ul 0.11 0.34 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39250 401
FHH-Chr YBN/Mcwi serum aspartate aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 9 125.56 U/l 11.16 33.47 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42462 401
FHH-Chr YBN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 9 0.32 mg/dl 0.01 0.04 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39589 401
FHH-Chr YBN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 9 0.17 x 1000 cells/ul 0.03 0.1 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39687 401
FHH-Chr YBN/Mcwi serum bicarbonate level control condition (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 9 25.89 mmol/l 1.06 3.18 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 43035 401
FHH-Chr YBN/Mcwi mean corpuscular hemoglobin control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 9 17.26 pg 0.07 0.21 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40243 401
FHH-Chr YBN/Mcwi serum alkaline phosphatase activity level control condition (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 9 426.44 U/l 14.56 43.68 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37495 401
FHH-Chr YBN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 13 0.02 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59403 526
FHH-Chr YBN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 9 0.14 mmHg x min x kg x ml-1 0.01 0.04 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59560 526
FHH-Chr YBN/Mcwi serum globulin level control condition (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 9 1.27 g/dl 0.04 0.12 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 41072 401
FHH-Chr YBN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass male 77 days-91 days 14 1.62 g/kg 0.03 0.12 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59670 526
FHH-Chr YBN/Mcwi serum glucose level control condition (for 14 days) PhysGen Biochemistry data blood glucose amount male 77 days-91 days 9 139.11 mg/dl 5.0 15.0 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41239 401
FHH-Chr YBN/Mcwi serum urea nitrogen level control condition (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77 days-91 days 9 22.56 mg/dl 1.29 3.88 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41797 401
FHH-Chr YBN/Mcwi left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 82.53 mmHg 5.21 16.49 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45517 461
FHH-Chr YBN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 11 -7.78 null 0.08 0.28 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 56141 522
FHH-Chr YBN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 8.45 ml/min/g 0.72 2.29 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46883 461
FHH-Chr YBN/Mcwi left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 43.02 mmHg 4.38 13.15 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47924 461
FHH-Chr YBN/Mcwi percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 66.53 % 5.32 16.82 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46079 461
FHH-Chr YBN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 202.79 beats/min 16.98 53.71 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45161 461
FHH-Chr YBN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 21 %change=VE during 2-3 min hypoxia/control during standard conditions 134.97 % 5.66 25.91 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13693 381
FHH-Chr YBN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine albumin amount male 80 days-99 days 5 157.26 mg/d 66.11 147.84 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52411 482
FHH-Chr YBN/Mcwi heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 9 234.2 beats/min 10.62 31.87 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48210 461
FHH-Chr YBN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 5.66 ml/min/g 0.47 1.48 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44731 461
FHH-Chr YBN/Mcwi heart contraction pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 10 33.5 mmHg 2.43 7.68 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48046 461
FHH-Chr YBN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 9 21.67 mmol/l 0.65 1.94 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38274 401
FHH-Chr YBN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 9 5.88 x 1000 cells/ul 0.27 0.81 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41516 401
FHH-Chr YBN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77 days-91 days 9 1.38 x 1000 cells/ul 0.1 0.31 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43237 401
FHH-Chr YBN/Mcwi red blood cell count control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 9 7.2 x 10E6 cells/ul 0.16 0.48 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42014 401
FHH-Chr YBN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 19 0.02 umol/l 0.0 0.01 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54710 522
FHH-Chr YBN/Mcwi time to peak heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 1211.3 s 34.15 107.98 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46561 461
FHH-Chr YBN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 21 124.17 % 8.02 36.74 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53769 381
FHH-Chr YBN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 21 104.07 % 3.92 17.95 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53901 381
FHH-Chr YBN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 21 100.31 % 3.22 14.74 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54002 381
FHH-Chr YBN/Mcwi mean corpuscular hemoglobin concentration control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 9 32.2 g/dl 0.14 0.43 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 37373 401
FHH-Chr YBN/Mcwi percent change in ventilation controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 21 %change=VE during 2-3 min hypercapnia/control during standard conditions 216.03 % 9.64 44.18 stop flow air displacement plethysmography 0 0 Moms and pups used in studies were fed Teklad 19224 381
FHH-Chr YBN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 9 3.78 g/dl 0.05 0.16 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42246 401
FHH-Chr YBN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 9 19.21 pg 0.13 0.39 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42558 401
FHH-Chr YBN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 9 115.0 U/l 8.13 24.38 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42783 401
FHH-Chr YBN/Mcwi total white blood cell count control condition (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 9 5.11 x 1000 cells/ul 0.37 1.11 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39930 401
FHH-Chr YBN/Mcwi plasma anion gap control condition (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 9 17.22 mmol/l 0.85 2.54 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 43176 401
FHH-Chr YBN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 8 4.58 mmol/l 0.13 0.37 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38079 401
FHH-Chr YBN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 42.62 mmHg 4.48 14.16 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46430 461
FHH-Chr YBN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 11 245.52 beats/min 5.91 19.62 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47595 461
FHH-Chr YBN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 10 19.68 IU/g 2.85 9.02 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 48890 461
FHH-Chr YBN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 19 76.11 % 3.46 15.09 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57260 522
FHH-Chr YBN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 9 55.13 ml/min/kg 3.91 11.72 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58012 526
FHH-Chr YBN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 9 0.03 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58502 526
FHH-Chr YBN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 11 87.09 % 4.85 16.09 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54816 522
FHH-Chr YBN/Mcwi methylene blue metabolism-surface area product after auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 13 12.27 ml/min/kg 1.27 4.58 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 60039 526
FHH-Chr YBN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 14 6.68 g/kg 0.22 0.81 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45652 461
FHH-Chr YBN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 51.19 % 3.43 10.84 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47090 461
FHH-Chr YBN/Mcwi respiration rate controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 21 146.73 breaths/min 4.18 19.14 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 17124 381
FHH-Chr YBN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 9 9.39 mg/dl 0.06 0.17 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36637 401
FHH-Chr YBN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 11 5.89 mmHg 0.11 0.35 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47210 461
FHH-Chr YBN/Mcwi heart weight to body weight ratio control condition PhysGen Cardiac data heart mass male 49 days-63 days 10 5.1 g/kg 0.24 0.77 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 47027 461
FHH-Chr YBN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 11 989.55 s 38.56 127.89 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49312 461
FHH-Chr YBN/Mcwi FAPGG metabolism-surface area product FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 13 38.39 ml/min/kg 3.31 11.93 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58271 526
FHH-Chr YBN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 11 0.48 IU/g 0.13 0.44 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47479 461
FHH-Chr YBN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 9 10.03 mg/dl 0.26 0.79 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37607 401
FHH-Chr YBN/Mcwi maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 11 0.79 g/mg 0.08 0.26 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57370 522
FHH-Chr YBN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 9 142.0 mmol/l 0.58 1.73 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39401 401
FHH-Chr YBN/Mcwi absolute change in body temperature controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 21 0.18 degrees C 0.09 0.42 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 15682 381
FHH-Chr YBN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 21 132.74 breaths/min 6.57 30.12 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14807 381
FHH-Chr YBN/Mcwi respiration rate control condition PhysGen Respiratory data respiratory function trait male 82 days-99 days 21 102.23 breaths/min 3.62 16.59 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14948 381
FHH-Chr YBN/Mcwi urine sodium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine sodium amount male 80 days-99 days 5 16.71 mEq/d 3.54 7.91 flame atomic emission spectrometry 0 Moms were fed Teklad, pups used in studies were fed Dyets 52805 482
FHH-Chr YBN/Mcwi body temperature control condition PhysGen Respiratory data body temperature trait male 82 days-99 days 21 36.61 degrees C 0.14 0.62 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 19082 381
FHH-Chr YBN/Mcwi heart wet weight control condition PhysGen Cardiac data heart mass male 49 days-63 days 10 0.63 g 0.05 0.17 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49073 461
FHH-Chr YBN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass male 49 days-63 days 14 98.1 g 2.6 9.8 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49554 461
FHH-Chr YBN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 11 9.53 % 2.47 8.18 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49711 461
FHH-Chr YBN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 9 107.44 mmol/l 0.34 1.01 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39130 401
FHH-Chr YBN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 21 131.81 % 6.11 28.01 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54342 381
FHH-Chr YBN/Mcwi percent change in respiration rate controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 21 151.1 % 4.77 21.85 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53650 381
FHH-Chr YBN/Mcwi hematocrit control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 9 38.59 % 0.91 2.74 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41347 401
FHH-Chr YBN/Mcwi blood eosinophil count control condition (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77 days-91 days 9 0.02 x 1000 cells/ul 0.01 0.04 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41449 401
FHH-Chr YBN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 42.52 % 6.57 20.76 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48540 461
FHH-Chr YBN/Mcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 21 26.86 ml/min 1.49 6.82 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16160 381
FHH-Chr YBN/Mcwi maximum contractile force per wet weight of aorta potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 19 1.38 g/mg 0.09 0.39 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55824 522
FHH-Chr YBN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 11 1.15 E-7mole 0.21 0.69 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56556 522
FHH-Chr YBN/Mcwi calculated pulmonary vascular resistance normalized to body weight Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 13 0.11 mmHg x min x kg x ml-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59933 526
FHH-Chr YBN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 11 94.77 mmHg 5.77 19.15 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45742 461
FHH-Chr YBN/Mcwi left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 77.05 mmHg 5.18 16.39 balloon tipped catheter with pressure transducer in isolated perfused heart 0 46763 461
FHH-Chr YBN/Mcwi left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 52.41 mmHg 4.57 14.47 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47714 461
FHH-Chr YBN/Mcwi body weight control condition PhysGen Cardiac data body mass male 49 days-63 days 10 123.9 g 9.3 29.3 whole body digital scale 0 Moms and pups used in studies were fed Teklad 47849 461
FHH-Chr YBN/Mcwi percent change in left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 56.54 % 7.37 22.12 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46332 461
FHH-Chr YBN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 21 33.72 ml/min 1.57 7.21 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20221 381
FHH-Chr YBN/Mcwi blood lymphocyte count control condition (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 9 3.93 x 1000 cells/ul 0.31 0.94 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 36914 401
FHH-Chr YBN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 21 0.27 ml 0.01 0.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13936 381
FHH-Chr YBN/Mcwi mean arterial blood pressure controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data arterial blood pressure trait male 80 days-99 days 4 164.84 mmHg 11.34 22.68 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52556 482
FHH-Chr YBN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 5.45 ml/min/g 0.42 1.34 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46214 461
FHH-Chr YBN/Mcwi tidal volume controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 21 0.38 ml 0.02 0.08 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 17383 381
FHH-Chr YBN/Mcwi percent change in heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 85.67 % 4.73 14.18 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48419 461
FHH-Chr YBN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 21 36.5 degrees C 0.62 2.84 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16585 381
FHH-Chr YBN/Mcwi percent change in tidal volume controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 21 148.24 % 6.04 27.7 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54441 381
FHH-Chr YBN/Mcwi blood hemoglobin level control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 9 12.43 g/dl 0.26 0.78 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40147 401
FHH-Chr YBN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 13 2.97 mg/kg 0.54 1.96 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58919 526
FHH-Chr YBN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass male 77 days-91 days 14 138.1 g 6.5 24.2 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59075 526
FHH-Chr YBN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 11 0.02 umol/l 0.0 0.01 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54942 522
FHH-Chr YBN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 14 1.13 mg/kg 0.19 0.73 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59209 526
FHH-Chr YBN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 13 0.52 null 0.05 0.19 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 59817 526