Phenominer Database Results (164 results)

 
 
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Strain Phenotype Conditions Study Experiment Name Sex Age # of Animals Formula Value Units SEM SD Method Method Duration Post Insult Time Value Clinical Measurement Notes Experiment Notes Record ID Study ID
FHH-Chr 7BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 10 339.0 U/l 16.09 50.88 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36461 401
FHH-Chr 7BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77 days-91 days 10 76.7 mg/dl 2.69 8.51 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37174 401
FHH-Chr 7BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 10 79.5 mg/dl 1.78 5.64 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37179 401
FHH-Chr 7BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 11 0.31 ml 0.04 0.12 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15311 381
FHH-Chr 7BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount female 77 days-91 days 10 9.24 mg/dl 0.06 0.2 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36701 401
FHH-Chr 7BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 10 9.26 mg/dl 0.11 0.36 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36706 401
FHH-Chr 7BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 10 1013.7 s 37.05 117.17 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49375 461
FHH-Chr 7BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 10 103.4 U/l 7.57 23.95 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42852 401
FHH-Chr 7BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity female 77 days-91 days 10 0.21 x 1000 cells/ul 0.05 0.16 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39751 401
FHH-Chr 7BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass female 77 days-91 days 10 176.2 g 2.9 9.2 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59139 526
FHH-Chr 7BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77 days-91 days 10 0.47 x 1000 cells/ul 0.09 0.29 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43301 401
FHH-Chr 7BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 10 9.56 mg/dl 0.29 0.91 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37676 401
FHH-Chr 7BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77 days-91 days 10 23.0 mg/dl 1.03 3.27 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40910 401
FHH-Chr 7BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77 days-91 days 10 35.8 U/l 2.35 7.42 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40791 401
FHH-Chr 7BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity female 77 days-91 days 10 52.25 % 0.56 1.78 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59334 526
FHH-Chr 7BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 10 6.76 g/kg 0.23 0.72 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45673 461
FHH-Chr 7BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 3 119.96 mmHg 9.79 16.96 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14370 381
FHH-Chr 7BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 41.23 mmHg 6.35 20.07 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45351 461
FHH-Chr 7BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 126.58 mmHg 4.4 13.92 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45805 461
FHH-Chr 7BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 10 5.56 mmol/l 0.23 0.72 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38148 401
FHH-Chr 7BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 10 0.41 IU/g 0.07 0.22 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47500 461
FHH-Chr 7BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 46.77 % 4.39 13.87 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48603 461
FHH-Chr 7BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 0.21 ml 0.04 0.11 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15316 381
FHH-Chr 7BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount male 82 days-99 days 2 31.88 mmHg 1.58 2.23 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17287 381
FHH-Chr 7BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 11 0.31 ml 0.03 0.09 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14001 381
FHH-Chr 7BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 0.2 ml 0.04 0.12 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14006 381
FHH-Chr 7BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 11 120.17 % 8.5 28.21 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54063 381
FHH-Chr 7BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 8 119.0 % 5.48 15.49 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54067 381
FHH-Chr 7BN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 3 -9.83 mmHg 1.39 2.4 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19672 381
FHH-Chr 7BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 11 37.21 ml/min 5.52 18.3 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18740 381
FHH-Chr 7BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 8 26.55 ml/min 2.74 7.75 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18745 381
FHH-Chr 7BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 10 5.24 g/dl 0.05 0.15 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37039 401
FHH-Chr 7BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 11 32.87 ml/min 4.5 14.94 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20286 381
FHH-Chr 7BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 8 24.41 ml/min 2.47 6.98 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20291 381
FHH-Chr 7BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 1184.9 s 46.01 145.49 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50308 461
FHH-Chr 7BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 10 893.2 s 72.32 228.71 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49380 461
FHH-Chr 7BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 10 6.3 % 1.67 5.3 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49779 461
FHH-Chr 7BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 102.23 mmHg 4.37 13.81 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49964 461
FHH-Chr 7BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 11 -0.02 degrees C 0.19 0.64 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20387 381
FHH-Chr 7BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass female 49 days-63 days 10 131.5 g 2.7 8.6 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49575 461
FHH-Chr 7BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass male 49 days-63 days 10 156.3 g 4.5 14.1 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49583 461
FHH-Chr 7BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77 days-91 days 10 19.2 mmol/l 0.39 1.23 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42139 401
FHH-Chr 7BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 10 58.75 fl 0.66 2.07 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38827 401
FHH-Chr 7BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77 days-91 days 10 92.1 U/l 6.7 21.18 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42847 401
FHH-Chr 7BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 10 110.0 mmol/l 0.58 1.83 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39199 401
FHH-Chr 7BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 10 141.8 mmol/l 0.66 2.1 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39470 401
FHH-Chr 7BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 10 31.98 g/dl 0.09 0.29 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39859 401
FHH-Chr 7BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77 days-91 days 10 0.33 mg/dl 0.02 0.07 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39653 401
FHH-Chr 7BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 10 1.65 mg/kg 0.45 1.42 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58983 526
FHH-Chr 7BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77 days-91 days 10 0.91 x 1000 cells/ul 0.13 0.42 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43306 401
FHH-Chr 7BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount female 77 days-91 days 10 1.32 g/dl 0.03 0.09 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40627 401
FHH-Chr 7BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77 days-91 days 10 19.7 mg/dl 0.93 2.95 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40905 401
FHH-Chr 7BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 10 17.8 g/dl 0.21 0.65 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38050 401
FHH-Chr 7BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77 days-91 days 10 4.92 x 1000 cells/ul 0.27 0.86 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41580 401
FHH-Chr 7BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 10 0.89 g 0.03 0.1 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45481 461
FHH-Chr 7BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 6 16.95 ml/min/kg 0.49 1.21 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57675 526
FHH-Chr 7BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 11 37.21 degrees C 0.16 0.52 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16650 381
FHH-Chr 7BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 6 0.46 null 0.02 0.06 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58190 526
FHH-Chr 7BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass female 77 days-91 days 10 0.4 null 0.01 0.04 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58810 526
FHH-Chr 7BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 11.56 ml/min/g 0.59 1.86 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46734 461
FHH-Chr 7BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 114.78 mmHg 8.06 25.49 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45810 461
FHH-Chr 7BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 41.32 % 2.69 8.51 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47153 461
FHH-Chr 7BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 3 449.72 beats/min 33.88 58.69 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17543 381
FHH-Chr 7BN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 3 -46.88 mmHg 6.1 10.56 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19503 381
FHH-Chr 7BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 56.92 mmHg 5.94 18.77 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45346 461
FHH-Chr 7BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 13.02 ml/min/g 0.59 1.88 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46729 461
FHH-Chr 7BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 10 0.29 IU/g 0.04 0.14 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47508 461
FHH-Chr 7BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount female 77 days-91 days 10 108.3 mmol/l 0.6 1.89 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39194 401
FHH-Chr 7BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 10 17.01 ml/min/kg 1.19 3.76 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57882 526
FHH-Chr 7BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77 days-91 days 10 200.9 U/l 4.51 14.25 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36456 401
FHH-Chr 7BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 8 108.27 breaths/min 5.42 15.34 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14877 381
FHH-Chr 7BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 3 428.88 beats/min 19.96 34.57 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17550 381
FHH-Chr 7BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 10 32.8 mmHg 2.61 8.24 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50073 461
FHH-Chr 7BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 10 52.25 % 0.56 1.78 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39068 401
FHH-Chr 7BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 10 55.68 % 0.65 2.06 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39073 401
FHH-Chr 7BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 10 31.8 g/dl 0.07 0.22 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39854 401
FHH-Chr 7BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 10 1.45 g/dl 0.05 0.16 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40632 401
FHH-Chr 7BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77 days-91 days 10 9.74 mg/dl 0.53 1.67 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37671 401
FHH-Chr 7BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77 days-91 days 10 5.66 x 1000 cells/ul 0.29 0.92 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41003 401
FHH-Chr 7BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount female 77 days-91 days 10 4.78 mmol/l 0.17 0.55 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38143 401
FHH-Chr 7BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount female 77 days-91 days 10 179.9 mg/dl 14.57 46.09 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38607 401
FHH-Chr 7BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount male 77 days-91 days 10 155.1 mg/dl 10.51 33.22 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38612 401
FHH-Chr 7BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77 days-91 days 10 0.1 mg/dl 0.0 0.0 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41945 401
FHH-Chr 7BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 81.14 % 3.08 9.73 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48832 461
FHH-Chr 7BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 6 19.86 ml/min/kg 1.2 2.95 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57877 526
FHH-Chr 7BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 10 43.34 ml/min/kg 2.09 6.59 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58081 526
FHH-Chr 7BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 10 0.39 null 0.02 0.06 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58195 526
FHH-Chr 7BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 10 6.68 g/kg 0.18 0.56 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45681 461
FHH-Chr 7BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 4.29 ml/min/g 0.35 1.11 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44799 461
FHH-Chr 7BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 5.13 mmHg 0.23 0.72 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47273 461
FHH-Chr 7BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 82.31 % 3.97 12.54 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48376 461
FHH-Chr 7BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 9 0.24 degrees C 0.2 0.61 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20392 381
FHH-Chr 7BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 11 122.03 % 6.03 20.0 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53962 381
FHH-Chr 7BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 8 122.57 breaths/min 8.44 23.87 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18348 381
FHH-Chr 7BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 8 %change=VE during 2-3 min hypoxia/control during standard conditions 141.74 % 7.25 20.5 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13763 381
FHH-Chr 7BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 5.42 ml/min/g 0.48 1.53 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44794 461
FHH-Chr 7BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 10 0.29 x 1000 cells/ul 0.07 0.21 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39756 401
FHH-Chr 7BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77 days-91 days 10 18.1 mmol/l 0.59 1.85 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38338 401
FHH-Chr 7BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 10 1261.7 s 43.13 136.4 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50303 461
FHH-Chr 7BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 86.82 % 9.05 28.6 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48837 461
FHH-Chr 7BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 255.48 beats/min 6.01 18.99 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47663 461
FHH-Chr 7BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 10 16.6 g/dl 0.16 0.51 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38045 401
FHH-Chr 7BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 11 124.01 % 12.71 42.16 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53830 381
FHH-Chr 7BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 2 50.9 mmHg 1.95 2.76 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20522 381
FHH-Chr 7BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77 days-91 days 10 58.88 fl 0.26 0.82 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38822 401
FHH-Chr 7BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount female 77 days-91 days 10 3.92 g/dl 0.04 0.13 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42310 401
FHH-Chr 7BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 10 17.5 mmol/l 0.82 2.59 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42144 401
FHH-Chr 7BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount female 77 days-91 days 10 140.8 mmol/l 0.77 2.44 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39465 401
FHH-Chr 7BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 10 8.87 x 10E6 cells/ul 0.08 0.27 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39314 401
FHH-Chr 7BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 10 9.49 x 10E6 cells/ul 0.15 0.46 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39319 401
FHH-Chr 7BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 8 124.2 % 5.3 14.98 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54407 381
FHH-Chr 7BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 10 2.34 mg/kg 0.46 1.46 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58988 526
FHH-Chr 7BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 10 6.51 x 1000 cells/ul 0.34 1.06 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41008 401
FHH-Chr 7BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass female 77 days-91 days 10 1.9 g/kg 0.04 0.14 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59734 526
FHH-Chr 7BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 0.15 mmHg x min x kg x ml-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59624 526
FHH-Chr 7BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 10 0.16 mmHg x min x kg x ml-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59629 526
FHH-Chr 7BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 10 20.1 mmol/l 0.38 1.2 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38343 401
FHH-Chr 7BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77 days-91 days 10 0.06 x 1000 cells/ul 0.02 0.05 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41724 401
FHH-Chr 7BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77 days-91 days 10 0.04 x 1000 cells/ul 0.02 0.07 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41729 401
FHH-Chr 7BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 10 247.25 beats/min 10.15 32.1 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47658 461
FHH-Chr 7BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 121.44 mmHg 4.38 13.85 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48700 461
FHH-Chr 7BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 54.1 mmHg 2.82 8.9 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46498 461
FHH-Chr 7BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 9 37.41 degrees C 0.22 0.65 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16655 381
FHH-Chr 7BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77 days-91 days 9 0.04 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58566 526
FHH-Chr 7BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 10 0.03 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58571 526
FHH-Chr 7BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 10 20.84 IU/g 1.94 6.12 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46008 461
FHH-Chr 7BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 4.98 mmHg 0.24 0.77 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47278 461
FHH-Chr 7BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 11 106.95 breaths/min 8.95 29.69 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14872 381
FHH-Chr 7BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 10 35.8 mmHg 3.26 10.29 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50078 461
FHH-Chr 7BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 10 3.83 g/dl 0.07 0.24 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42315 401
FHH-Chr 7BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 11 %change=VE during 2-3 min hypoxia/control during standard conditions 163.49 % 20.03 66.44 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13758 381
FHH-Chr 7BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount female 82 days-99 days 3 28.28 mmHg 1.37 2.38 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17280 381
FHH-Chr 7BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 3 146.22 mmHg 6.39 11.06 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14377 381
FHH-Chr 7BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 8 115.08 % 6.23 17.61 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53966 381
FHH-Chr 7BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 8 110.9 % 6.17 17.46 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53834 381
FHH-Chr 7BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 11 117.68 breaths/min 10.83 35.93 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18343 381
FHH-Chr 7BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 10 5.28 g/dl 0.12 0.37 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37044 401
FHH-Chr 7BN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 2 -5.0 mmHg 1.1 1.56 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19679 381
FHH-Chr 7BN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 2 -43.5 mmHg 4.3 6.08 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19510 381
FHH-Chr 7BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 3 51.7 mmHg 1.25 2.17 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20515 381
FHH-Chr 7BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 10 18.73 pg 0.07 0.21 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42622 401
FHH-Chr 7BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 10 18.78 pg 0.17 0.54 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42627 401
FHH-Chr 7BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 10 0.32 mg/dl 0.02 0.08 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39658 401
FHH-Chr 7BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass male 77 days-91 days 10 206.4 g 11.8 37.2 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59144 526
FHH-Chr 7BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77 days-91 days 10 55.68 % 0.65 2.06 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59339 526
FHH-Chr 7BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 10 45.2 U/l 3.59 11.34 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40796 401
FHH-Chr 7BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 10 5.27 x 1000 cells/ul 0.28 0.88 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41585 401
FHH-Chr 7BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 10 0.1 mg/dl 0.01 0.02 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41950 401
FHH-Chr 7BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 45.31 mmHg 3.5 11.06 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46493 461
FHH-Chr 7BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 40.61 % 8.64 27.32 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48608 461
FHH-Chr 7BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 109.79 mmHg 8.08 25.54 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48705 461
FHH-Chr 7BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 10 1.04 g 0.04 0.14 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45486 461
FHH-Chr 7BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 10 14.8 ml/min/kg 0.59 1.88 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57680 526
FHH-Chr 7BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 44.4 ml/min/kg 3.69 11.08 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58076 526
FHH-Chr 7BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass male 77 days-91 days 10 0.43 null 0.02 0.08 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58815 526
FHH-Chr 7BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 10 13.26 IU/g 2.44 7.71 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46014 461
FHH-Chr 7BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 10 199.74 beats/min 14.67 46.38 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45224 461
FHH-Chr 7BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 39.21 % 5.97 18.87 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47158 461
FHH-Chr 7BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 80.76 % 5.14 16.26 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48371 461
FHH-Chr 7BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 210.62 beats/min 11.76 37.17 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45229 461
FHH-Chr 7BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 11 136.82 % 15.87 52.62 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54403 381
FHH-Chr 7BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 95.33 mmHg 5.64 17.82 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49969 461
FHH-Chr 7BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 10 3.66 % 1.3 4.1 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49774 461
FHH-Chr 7BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass male 77 days-91 days 10 1.57 g/kg 0.04 0.13 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59739 526