FHH-Chr 1BN/Mcwi |
partial pressure of blood carbon dioxide (Pco2) |
controlled air oxygen content (12 %) (for 0.1 hours) |
PhysGen Respiratory data |
blood gas amount |
female |
82 days-99 days |
8 |
|
27.34 |
mmHg |
0.66 |
1.85 |
automated blood gas analysis using a Bayer analyzer |
|
0 |
|
Moms and pups used in studies were fed Teklad |
17289 |
381 |
FHH-Chr 1BN/Mcwi |
tidal volume |
controlled air oxygen content (12 %) (between 0 and 0.1 hours) |
PhysGen Respiratory data |
pulmonary ventilation trait |
male |
82 days-99 days |
18 |
|
0.37 |
ml |
0.02 |
0.08 |
stop flow air displacement plethysmography |
|
0 |
|
Moms and pups used in studies were fed Teklad |
13938 |
381 |
FHH-Chr 1BN/Mcwi |
tidal volume |
controlled air oxygen content (12 %) (between 0 and 0.1 hours) |
PhysGen Respiratory data |
pulmonary ventilation trait |
female |
82 days-99 days |
16 |
|
0.33 |
ml |
0.01 |
0.05 |
stop flow air displacement plethysmography |
|
0 |
|
Moms and pups used in studies were fed Teklad |
13949 |
381 |
FHH-Chr 1BN/Mcwi |
mean arterial blood pressure |
controlled air oxygen content (12 %) (for 0.1 hours) |
PhysGen Respiratory data |
arterial blood pressure trait |
male |
82 days-99 days |
15 |
|
121.71 |
mmHg |
4.05 |
15.7 |
vascular fluid filled catheter |
|
0 |
|
Moms and pups used in studies were fed Teklad |
14358 |
381 |
FHH-Chr 1BN/Mcwi |
heart rate |
controlled air oxygen content (12 %) (for 0.1 hours) |
PhysGen Respiratory data |
heart pumping trait |
male |
82 days-99 days |
15 |
|
425.56 |
beats/min |
14.49 |
56.12 |
vascular fluid filled catheter |
|
0 |
|
Moms and pups used in studies were fed Teklad |
17531 |
381 |
FHH-Chr 1BN/Mcwi |
partial pressure of blood oxygen |
controlled air oxygen content (12 %) (for 0.1 hours) |
PhysGen Respiratory data |
blood oxygen amount |
female |
82 days-99 days |
8 |
|
61.21 |
mmHg |
0.96 |
2.71 |
automated blood gas analysis using a Bayer analyzer |
|
0 |
|
Moms and pups used in studies were fed Teklad |
20524 |
381 |
FHH-Chr 1BN/Mcwi |
absolute change in body temperature |
controlled air oxygen content (12 %) (for 0.1 hours) |
PhysGen Respiratory data |
body temperature trait |
male |
82 days-99 days |
18 |
|
-0.34 |
degrees C |
0.19 |
0.82 |
digital rectal thermometry |
|
0 |
|
Moms and pups used in studies were fed Teklad |
20324 |
381 |
FHH-Chr 1BN/Mcwi |
serum chloride level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood chloride amount |
female |
77 days-91 days |
9 |
|
111.56 |
mmol/l |
0.71 |
2.13 |
standard blood chemistry panel |
|
0 |
|
Moms and pups used in studies were fed Teklad |
39143 |
401 |
FHH-Chr 1BN/Mcwi |
percent change in respiration rate |
controlled air oxygen content (12 %) (between 0 and 0.1 hours) |
PhysGen Respiratory data |
respiratory function trait |
male |
82 days-99 days |
18 |
|
124.99 |
% |
5.18 |
21.99 |
stop flow air displacement plethysmography |
|
0 |
|
Moms and pups used in studies were fed Teklad |
54344 |
381 |
FHH-Chr 1BN/Mcwi |
dose of methacholine at which pulmonary conductance is half its pretreatment value |
controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) |
PhysGen Lung data |
pulmonary ventilation trait |
female |
77 days-91 days |
9 |
|
2.96 |
mg/kg |
1.01 |
3.03 |
stop flow air displacement plethysmography |
|
0 |
|
Moms and pups used in studies were fed Teklad |
58932 |
526 |
FHH-Chr 1BN/Mcwi |
blood hemoglobin level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood hemoglobin amount |
male |
77 days-91 days |
13 |
|
18.48 |
g/dl |
0.33 |
1.2 |
automated blood cell counting method |
|
0 |
|
Moms and pups used in studies were fed Teklad |
37983 |
401 |
FHH-Chr 1BN/Mcwi |
lung dry weight to body weight ratio |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Lung data |
lung mass |
female |
77 days-91 days |
10 |
|
1.79 |
g/kg |
0.05 |
0.15 |
digital scale post excision weight measurement |
|
0 |
|
Moms and pups used in studies were fed Teklad |
59683 |
526 |
FHH-Chr 1BN/Mcwi |
heart wet weight |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Cardiac data |
heart mass |
male |
49 days-63 days |
10 |
|
1.0 |
g |
0.05 |
0.14 |
digital scale post excision weight measurement |
|
0 |
|
Moms and pups used in studies were fed Teklad |
45420 |
461 |
FHH-Chr 1BN/Mcwi |
serum glucose level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood glucose amount |
female |
77 days-91 days |
9 |
|
129.56 |
mg/dl |
4.75 |
14.26 |
standard blood chemistry panel |
|
0 |
|
Moms and pups used in studies were fed Teklad |
38556 |
401 |
FHH-Chr 1BN/Mcwi |
serum total bilirubin level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood bilirubin amount |
female |
77 days-91 days |
9 |
|
0.1 |
mg/dl |
0.0 |
0.0 |
standard blood chemistry panel |
|
0 |
|
Moms and pups used in studies were fed Teklad |
41894 |
401 |
FHH-Chr 1BN/Mcwi |
methylene blue metabolism-surface area product without auto-oxidation |
controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) |
PhysGen Lung data |
pulmonary blood flow trait |
male |
77 days-91 days |
13 |
|
20.4 |
ml/min/kg |
2.16 |
7.8 |
isolated perfused lung vascular effluent collection |
|
0 |
|
Moms and pups used in studies were fed Teklad |
57815 |
526 |
FHH-Chr 1BN/Mcwi |
FAPGG metabolism-surface area product |
controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) |
PhysGen Lung data |
pulmonary blood flow trait |
female |
77 days-91 days |
10 |
|
50.5 |
ml/min/kg |
3.82 |
12.09 |
isolated perfused lung vascular effluent collection |
|
0 |
|
Moms and pups used in studies were fed Teklad |
58025 |
526 |
FHH-Chr 1BN/Mcwi |
heart rate |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) |
PhysGen Cardiac data |
heart pumping trait |
male |
49 days-63 days |
10 |
|
260.6 |
beats/min |
21.86 |
69.14 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
Moms and pups used in studies were fed Teklad |
45163 |
461 |
FHH-Chr 1BN/Mcwi |
heart rate |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) |
PhysGen Cardiac data |
heart pumping trait |
female |
49 days-63 days |
10 |
|
223.08 |
beats/min |
5.09 |
16.11 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
Moms and pups used in studies were fed Teklad |
45174 |
461 |
FHH-Chr 1BN/Mcwi |
minute ventilation |
controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) |
PhysGen Respiratory data |
pulmonary ventilation trait |
male |
82 days-99 days |
18 |
|
42.73 |
ml/min |
1.9 |
8.07 |
stop flow air displacement plethysmography |
|
0 |
|
Moms and pups used in studies were fed Teklad |
20223 |
381 |
FHH-Chr 1BN/Mcwi |
percent change in respiration rate |
controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) |
PhysGen Respiratory data |
respiratory function trait |
female |
82 days-99 days |
16 |
|
119.63 |
% |
8.05 |
32.18 |
stop flow air displacement plethysmography |
|
0 |
|
Moms and pups used in studies were fed Teklad |
53780 |
381 |
FHH-Chr 1BN/Mcwi |
percent change in heart rate |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) |
PhysGen Cardiac data |
heart pumping trait |
female |
49 days-63 days |
10 |
post-ischemic value/pre-ischemic value x 100% |
93.4 |
% |
3.73 |
11.8 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
Moms and pups used in studies were fed Teklad |
48321 |
461 |
FHH-Chr 1BN/Mcwi |
heart weight to body weight ratio |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Cardiac data |
heart mass |
male |
49 days-63 days |
10 |
|
6.47 |
g/kg |
0.24 |
0.76 |
digital scale post excision weight measurement |
|
0 |
|
Moms and pups used in studies were fed Teklad |
45659 |
461 |
FHH-Chr 1BN/Mcwi |
heart wet weight |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Cardiac data |
heart mass |
female |
49 days-63 days |
10 |
|
0.85 |
g |
0.04 |
0.12 |
digital scale post excision weight measurement |
|
0 |
|
Moms and pups used in studies were fed Teklad |
45431 |
461 |
FHH-Chr 1BN/Mcwi |
serum phosphate level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood phosphate amount |
male |
77 days-91 days |
15 |
|
8.84 |
mg/dl |
0.38 |
1.49 |
standard blood chemistry panel |
|
0 |
|
Moms and pups used in studies were fed Teklad |
37609 |
401 |
FHH-Chr 1BN/Mcwi |
hematocrit |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
erythrocyte quantity |
male |
77 days-91 days |
13 |
|
56.87 |
% |
0.59 |
2.14 |
automated blood cell counting method |
|
0 |
|
Moms and pups used in studies were fed Teklad |
39006 |
401 |
FHH-Chr 1BN/Mcwi |
blood pH |
controlled air oxygen content (12 %) (for 0.1 hours) |
PhysGen Respiratory data |
blood acidity-alkalinity balance trait |
female |
82 days-99 days |
8 |
|
7.48 |
null |
0.01 |
0.03 |
automated blood gas analysis using a Bayer analyzer |
|
0 |
|
Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks |
17095 |
381 |
FHH-Chr 1BN/Mcwi |
percent change in tidal volume |
controlled air oxygen content (12 %) (between 0 and 0.1 hours) |
PhysGen Respiratory data |
pulmonary ventilation trait |
female |
82 days-99 days |
16 |
|
108.51 |
% |
3.5 |
14.0 |
stop flow air displacement plethysmography |
|
0 |
|
Moms and pups used in studies were fed Teklad |
53912 |
381 |
FHH-Chr 1BN/Mcwi |
absolute change in partial pressure of blood carbon dioxide |
controlled air oxygen content (12 %) (for 0.1 hours) |
PhysGen Respiratory data |
blood carbon dioxide amount |
female |
82 days-99 days |
7 |
|
-5.77 |
mmHg |
0.62 |
1.65 |
automated blood gas analysis using a Bayer analyzer |
|
0 |
|
Moms and pups used in studies were fed Teklad |
19681 |
381 |
FHH-Chr 1BN/Mcwi |
body weight |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Cardiac data |
body mass |
male |
49 days-63 days |
10 |
|
154.6 |
g |
7.1 |
22.4 |
whole body digital scale |
|
0 |
|
Moms and pups used in studies were fed Teklad |
49561 |
461 |
FHH-Chr 1BN/Mcwi |
left ventricular systolic blood pressure |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) |
PhysGen Cardiac data |
heart left ventricular blood pressure trait |
male |
49 days-63 days |
9 |
|
94.47 |
mmHg |
5.26 |
15.79 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
Moms and pups used in studies were fed Teklad |
49903 |
461 |
FHH-Chr 1BN/Mcwi |
heart left ventricle infarction weight to total heart left ventricle weight ratio |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) |
PhysGen Cardiac data |
heart left ventricle integrity trait |
male |
49 days-63 days |
10 |
|
10.78 |
% |
4.5 |
14.23 |
digital scale post excision weight measurement |
|
0 |
|
Moms and pups used in studies were fed Teklad |
49713 |
461 |
FHH-Chr 1BN/Mcwi |
heart left ventricle infarction weight to total heart left ventricle weight ratio |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) |
PhysGen Cardiac data |
heart left ventricle integrity trait |
female |
49 days-63 days |
10 |
|
9.2 |
% |
4.39 |
13.88 |
digital scale post excision weight measurement |
|
0 |
|
Moms and pups used in studies were fed Teklad |
49724 |
461 |
FHH-Chr 1BN/Mcwi |
serum chloride level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood chloride amount |
male |
77 days-91 days |
15 |
|
110.27 |
mmol/l |
1.08 |
4.17 |
standard blood chemistry panel |
|
0 |
|
Moms and pups used in studies were fed Teklad |
39132 |
401 |
FHH-Chr 1BN/Mcwi |
blood monocyte count |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
monocyte quantity |
male |
77 days-91 days |
13 |
|
0.28 |
x 1000 cells/ul |
0.05 |
0.16 |
automated blood cell counting method |
|
0 |
|
Moms and pups used in studies were fed Teklad |
39689 |
401 |
FHH-Chr 1BN/Mcwi |
total white blood cell count |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
leukocyte quantity |
female |
77 days-91 days |
9 |
|
4.11 |
x 1000 cells/ul |
0.44 |
1.33 |
automated blood cell counting method |
|
0 |
|
Moms and pups used in studies were fed Teklad |
40952 |
401 |
FHH-Chr 1BN/Mcwi |
lung dry weight to body weight ratio |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Lung data |
lung mass |
male |
77 days-91 days |
16 |
|
1.52 |
g/kg |
0.07 |
0.26 |
digital scale post excision weight measurement |
|
0 |
|
Moms and pups used in studies were fed Teklad |
59672 |
526 |
FHH-Chr 1BN/Mcwi |
heart rate |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) |
PhysGen Cardiac data |
heart pumping trait |
male |
49 days-63 days |
10 |
|
278.29 |
beats/min |
12.74 |
40.29 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
Moms and pups used in studies were fed Teklad |
47597 |
461 |
FHH-Chr 1BN/Mcwi |
left ventricular developed pressure |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) |
PhysGen Cardiac data |
heart left ventricular blood pressure trait |
male |
49 days-63 days |
10 |
|
143.14 |
mmHg |
6.57 |
20.76 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
Moms and pups used in studies were fed Teklad |
48639 |
461 |
FHH-Chr 1BN/Mcwi |
left ventricular diastolic blood pressure |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) |
PhysGen Cardiac data |
heart left ventricular blood pressure trait |
male |
49 days-63 days |
9 |
|
54.65 |
mmHg |
3.65 |
10.95 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
Moms and pups used in studies were fed Teklad |
46432 |
461 |
FHH-Chr 1BN/Mcwi |
serum total bilirubin level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood bilirubin amount |
male |
77 days-91 days |
15 |
|
0.1 |
mg/dl |
0.0 |
0.0 |
standard blood chemistry panel |
|
0 |
|
Moms and pups used in studies were fed Teklad |
41883 |
401 |
FHH-Chr 1BN/Mcwi |
methylene blue metabolism-surface area product after auto-oxidation |
controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) |
PhysGen Lung data |
pulmonary blood flow trait |
male |
77 days-91 days |
13 |
|
15.64 |
ml/min/kg |
1.23 |
4.43 |
isolated perfused lung vascular effluent collection |
|
0 |
|
Moms and pups used in studies were fed Teklad |
57613 |
526 |
FHH-Chr 1BN/Mcwi |
percent change in left ventricular systolic blood pressure |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) |
PhysGen Cardiac data |
heart pumping trait |
female |
49 days-63 days |
10 |
post-ischemic value/pre-ischemic value x 100% |
68.29 |
% |
3.41 |
10.79 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
Moms and pups used in studies were fed Teklad |
48782 |
461 |
FHH-Chr 1BN/Mcwi |
methylene blue metabolism-surface area product without auto-oxidation |
controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) |
PhysGen Lung data |
pulmonary blood flow trait |
female |
77 days-91 days |
10 |
|
15.45 |
ml/min/kg |
0.91 |
2.87 |
isolated perfused lung vascular effluent collection |
|
0 |
|
Moms and pups used in studies were fed Teklad |
57826 |
526 |
FHH-Chr 1BN/Mcwi |
arterial blood flow rate |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) |
PhysGen Cardiac data |
arterial blood flow trait |
male |
49 days-63 days |
10 |
|
14.88 |
ml/min/g |
1.14 |
3.59 |
isolated perfused heart effluent collection |
|
0 |
|
Moms and pups used in studies were fed Teklad |
46668 |
461 |
FHH-Chr 1BN/Mcwi |
tidal volume |
controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) |
PhysGen Respiratory data |
pulmonary ventilation trait |
male |
82 days-99 days |
18 |
|
0.35 |
ml |
0.02 |
0.08 |
stop flow air displacement plethysmography |
|
0 |
|
Moms and pups used in studies were fed Teklad |
15248 |
381 |
FHH-Chr 1BN/Mcwi |
respiration rate |
controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) |
PhysGen Respiratory data |
respiratory function trait |
female |
82 days-99 days |
16 |
|
113.79 |
breaths/min |
5.38 |
21.54 |
stop flow air displacement plethysmography |
|
0 |
|
Moms and pups used in studies were fed Teklad |
14820 |
381 |
FHH-Chr 1BN/Mcwi |
left ventricular developed pressure |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) |
PhysGen Cardiac data |
heart left ventricular blood pressure trait |
female |
49 days-63 days |
10 |
|
53.5 |
mmHg |
6.47 |
20.46 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
Moms and pups used in studies were fed Teklad |
45296 |
461 |
FHH-Chr 1BN/Mcwi |
arterial blood flow rate |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) |
PhysGen Cardiac data |
arterial blood flow trait |
female |
49 days-63 days |
10 |
|
7.43 |
ml/min/g |
0.25 |
0.79 |
isolated perfused heart effluent collection |
|
0 |
|
Moms and pups used in studies were fed Teklad |
44744 |
461 |
FHH-Chr 1BN/Mcwi |
plasma anion gap |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
ion homeostasis trait |
male |
77 days-91 days |
15 |
|
26.87 |
mmol/l |
0.75 |
2.9 |
standard blood chemistry panel |
|
0 |
|
Moms and pups used in studies were fed Teklad |
38276 |
401 |
FHH-Chr 1BN/Mcwi |
plasma creatinine level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood creatinine amount |
male |
77 days-91 days |
15 |
|
0.28 |
mg/dl |
0.01 |
0.06 |
automated plasma creatinine analysis |
|
0 |
|
Moms and pups used in studies were fed Teklad |
39591 |
401 |
FHH-Chr 1BN/Mcwi |
serum alanine aminotransferase activity level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood alanine transaminase amount |
male |
77 days-91 days |
15 |
|
89.13 |
U/l |
10.4 |
40.29 |
standard blood chemistry panel |
|
0 |
|
Moms and pups used in studies were fed Teklad |
40729 |
401 |
FHH-Chr 1BN/Mcwi |
serum urea nitrogen level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood urea nitrogen amount |
female |
77 days-91 days |
9 |
|
19.89 |
mg/dl |
1.18 |
3.55 |
standard blood chemistry panel |
|
0 |
|
Moms and pups used in studies were fed Teklad |
40854 |
401 |
FHH-Chr 1BN/Mcwi |
calculated pulmonary vascular resistance normalized to body weight |
controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) |
PhysGen Lung data |
pulmonary blood flow trait |
female |
77 days-91 days |
10 |
|
0.15 |
mmHg x min x kg x ml-1 |
0.01 |
0.02 |
fluid-filled catheter with pressure transducer in isolated perfused lung |
|
0 |
|
Moms and pups used in studies were fed Teklad |
59573 |
526 |
FHH-Chr 1BN/Mcwi |
serum potassium level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood potassium amount |
male |
77 days-91 days |
10 |
|
5.31 |
mmol/l |
0.11 |
0.35 |
standard blood chemistry panel |
|
0 |
|
Moms and pups used in studies were fed Teklad |
38081 |
401 |
FHH-Chr 1BN/Mcwi |
percent change in tidal volume |
controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) |
PhysGen Respiratory data |
pulmonary ventilation trait |
male |
82 days-99 days |
18 |
|
106.74 |
% |
3.08 |
13.07 |
stop flow air displacement plethysmography |
|
0 |
|
Moms and pups used in studies were fed Teklad |
54004 |
381 |
FHH-Chr 1BN/Mcwi |
percent change in tidal volume |
controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) |
PhysGen Respiratory data |
pulmonary ventilation trait |
female |
82 days-99 days |
16 |
|
106.0 |
% |
4.38 |
17.51 |
stop flow air displacement plethysmography |
|
0 |
|
Moms and pups used in studies were fed Teklad |
54013 |
381 |
FHH-Chr 1BN/Mcwi |
mean arterial blood pressure |
controlled air oxygen content (12 %) (for 0.1 hours) |
PhysGen Respiratory data |
arterial blood pressure trait |
female |
82 days-99 days |
7 |
|
116.98 |
mmHg |
6.2 |
16.39 |
vascular fluid filled catheter |
|
0 |
|
Moms and pups used in studies were fed Teklad |
14379 |
381 |
FHH-Chr 1BN/Mcwi |
absolute change in partial pressure of blood carbon dioxide |
controlled air oxygen content (12 %) (for 0.1 hours) |
PhysGen Respiratory data |
blood carbon dioxide amount |
male |
82 days-99 days |
9 |
|
-6.23 |
mmHg |
0.45 |
1.35 |
automated blood gas analysis using a Bayer analyzer |
|
0 |
|
Moms and pups used in studies were fed Teklad |
19660 |
381 |
FHH-Chr 1BN/Mcwi |
minute ventilation |
controlled air oxygen content (12 %) (between 0 and 0.1 hours) |
PhysGen Respiratory data |
pulmonary ventilation trait |
male |
82 days-99 days |
18 |
|
47.81 |
ml/min |
2.7 |
11.46 |
stop flow air displacement plethysmography |
|
0 |
|
Moms and pups used in studies were fed Teklad |
18677 |
381 |
FHH-Chr 1BN/Mcwi |
minute ventilation |
controlled air oxygen content (12 %) (between 0 and 0.1 hours) |
PhysGen Respiratory data |
pulmonary ventilation trait |
female |
82 days-99 days |
16 |
|
40.16 |
ml/min |
2.01 |
8.06 |
stop flow air displacement plethysmography |
|
0 |
|
Moms and pups used in studies were fed Teklad |
18688 |
381 |
FHH-Chr 1BN/Mcwi |
partial pressure of blood oxygen |
controlled air oxygen content (12 %) (for 0.1 hours) |
PhysGen Respiratory data |
blood oxygen amount |
male |
82 days-99 days |
11 |
|
55.07 |
mmHg |
1.17 |
3.89 |
automated blood gas analysis using a Bayer analyzer |
|
0 |
|
Moms and pups used in studies were fed Teklad |
20503 |
381 |
FHH-Chr 1BN/Mcwi |
heart contraction pressure |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) |
PhysGen Cardiac data |
heart muscle contractility trait |
male |
49 days-63 days |
10 |
|
43.4 |
mmHg |
3.35 |
10.61 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
Moms and pups used in studies were fed Teklad |
50012 |
461 |
FHH-Chr 1BN/Mcwi |
heart contraction pressure |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) |
PhysGen Cardiac data |
heart muscle contractility trait |
female |
49 days-63 days |
10 |
|
43.3 |
mmHg |
2.9 |
9.17 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
Moms and pups used in studies were fed Teklad |
50023 |
461 |
FHH-Chr 1BN/Mcwi |
serum albumin level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood albumin amount |
male |
77 days-91 days |
15 |
|
3.89 |
g/dl |
0.05 |
0.19 |
standard blood chemistry panel |
|
0 |
|
Moms and pups used in studies were fed Teklad |
42248 |
401 |
FHH-Chr 1BN/Mcwi |
serum bicarbonate level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood bicarbonate amount |
female |
77 days-91 days |
9 |
|
14.89 |
mmol/l |
0.7 |
2.09 |
standard blood chemistry panel |
|
0 |
|
Moms and pups used in studies were fed Teklad |
42088 |
401 |
FHH-Chr 1BN/Mcwi |
blood monocyte count |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
monocyte quantity |
female |
77 days-91 days |
9 |
|
0.26 |
x 1000 cells/ul |
0.06 |
0.18 |
automated blood cell counting method |
|
0 |
|
Moms and pups used in studies were fed Teklad |
39700 |
401 |
FHH-Chr 1BN/Mcwi |
serum glucose level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood glucose amount |
male |
77 days-91 days |
15 |
|
144.6 |
mg/dl |
6.97 |
26.99 |
standard blood chemistry panel |
|
0 |
|
Moms and pups used in studies were fed Teklad |
38545 |
401 |
FHH-Chr 1BN/Mcwi |
percent change in left ventricular developed pressure |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) |
PhysGen Cardiac data |
heart left ventricular blood pressure trait |
male |
49 days-63 days |
10 |
post-ischemic value/pre-ischemic value x 100% |
26.78 |
% |
6.6 |
20.88 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
Moms and pups used in studies were fed Teklad |
48542 |
461 |
FHH-Chr 1BN/Mcwi |
methylene blue metabolism-surface area product after auto-oxidation |
controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) |
PhysGen Lung data |
pulmonary blood flow trait |
female |
77 days-91 days |
10 |
|
13.84 |
ml/min/kg |
0.9 |
2.84 |
isolated perfused lung vascular effluent collection |
|
0 |
|
Moms and pups used in studies were fed Teklad |
57624 |
526 |
FHH-Chr 1BN/Mcwi |
body temperature |
controlled air oxygen content (12 %) (for 0.1 hours) |
PhysGen Respiratory data |
body temperature trait |
male |
82 days-99 days |
18 |
|
37.47 |
degrees C |
0.16 |
0.67 |
digital rectal thermometry |
|
0 |
|
Moms and pups used in studies were fed Teklad |
16587 |
381 |
FHH-Chr 1BN/Mcwi |
dose of methacholine at which pulmonary conductance is half its pretreatment value |
controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) |
PhysGen Lung data |
pulmonary ventilation trait |
male |
77 days-91 days |
13 |
|
2.78 |
mg/kg |
0.54 |
1.93 |
stop flow air displacement plethysmography |
|
0 |
|
Moms and pups used in studies were fed Teklad |
58921 |
526 |
FHH-Chr 1BN/Mcwi |
percent change in arterial blood flow rate |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) |
PhysGen Cardiac data |
arterial blood flow trait |
male |
49 days-63 days |
10 |
post-ischemic value/pre-ischemic value x 100% |
47.68 |
% |
2.98 |
9.41 |
isolated perfused heart effluent collection |
|
0 |
|
Moms and pups used in studies were fed Teklad |
47092 |
461 |
FHH-Chr 1BN/Mcwi |
percent change in ventilation |
controlled air oxygen content (12 %) (between 0 and 0.1 hours) |
PhysGen Respiratory data |
pulmonary ventilation trait |
male |
82 days-99 days |
18 |
%change=VE during 2-3 min hypoxia/control during standard conditions |
143.73 |
% |
7.23 |
30.66 |
stop flow air displacement plethysmography |
|
0 |
|
Moms and pups used in studies were fed Teklad |
13695 |
381 |
FHH-Chr 1BN/Mcwi |
serum calcium level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood calcium amount |
female |
77 days-91 days |
9 |
|
8.91 |
mg/dl |
0.11 |
0.32 |
standard blood chemistry panel |
|
0 |
|
Moms and pups used in studies were fed Teklad |
36650 |
401 |
FHH-Chr 1BN/Mcwi |
absolute change in partial pressure of blood oxygen |
controlled air oxygen content (12 %) (for 0.1 hours) |
PhysGen Respiratory data |
blood oxygen amount |
female |
82 days-99 days |
7 |
|
-52.91 |
mmHg |
4.32 |
11.43 |
automated blood gas analysis using a Bayer analyzer |
|
0 |
|
Moms and pups used in studies were fed Teklad |
19512 |
381 |
FHH-Chr 1BN/Mcwi |
left ventricular diastolic blood pressure |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) |
PhysGen Cardiac data |
heart left ventricular blood pressure trait |
female |
49 days-63 days |
10 |
|
5.18 |
mmHg |
0.24 |
0.77 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
Moms and pups used in studies were fed Teklad |
47223 |
461 |
FHH-Chr 1BN/Mcwi |
methylene blue to FAPGG metabolism-surface area product ratio |
controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) |
PhysGen Lung data |
pulmonary blood flow trait |
male |
77 days-91 days |
12 |
|
0.41 |
null |
0.04 |
0.15 |
isolated perfused lung vascular effluent collection |
|
0 |
|
Moms and pups used in studies were fed Teklad |
58128 |
526 |
FHH-Chr 1BN/Mcwi |
methylene blue to FAPGG metabolism-surface area product ratio |
controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) |
PhysGen Lung data |
pulmonary blood flow trait |
female |
77 days-91 days |
10 |
|
0.31 |
null |
0.02 |
0.07 |
isolated perfused lung vascular effluent collection |
|
0 |
|
Moms and pups used in studies were fed Teklad |
58139 |
526 |
FHH-Chr 1BN/Mcwi |
blood eosinophil count |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
eosinophil quantity |
female |
77 days-91 days |
9 |
|
0.02 |
x 1000 cells/ul |
0.01 |
0.03 |
automated blood cell counting method |
|
0 |
|
Moms and pups used in studies were fed Teklad |
41673 |
401 |
FHH-Chr 1BN/Mcwi |
body weight |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Cardiac data |
body mass |
female |
49 days-63 days |
10 |
|
139.2 |
g |
6.4 |
20.1 |
whole body digital scale |
|
0 |
|
Moms and pups used in studies were fed Teklad |
49586 |
461 |
FHH-Chr 1BN/Mcwi |
left ventricular diastolic blood pressure |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) |
PhysGen Cardiac data |
heart left ventricular blood pressure trait |
female |
49 days-63 days |
10 |
|
50.14 |
mmHg |
2.18 |
6.89 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
Moms and pups used in studies were fed Teklad |
46443 |
461 |
FHH-Chr 1BN/Mcwi |
blood neutrophil count |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
neutrophil quantity |
female |
77 days-91 days |
9 |
|
0.61 |
x 1000 cells/ul |
0.05 |
0.16 |
automated blood cell counting method |
|
0 |
|
Moms and pups used in studies were fed Teklad |
43250 |
401 |
FHH-Chr 1BN/Mcwi |
heart rate |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) |
PhysGen Cardiac data |
heart pumping trait |
female |
49 days-63 days |
10 |
|
241.58 |
beats/min |
8.76 |
27.71 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
Moms and pups used in studies were fed Teklad |
47608 |
461 |
FHH-Chr 1BN/Mcwi |
time to peak heart contraction |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) |
PhysGen Cardiac data |
heart pumping trait |
female |
49 days-63 days |
10 |
|
1154.0 |
s |
24.51 |
77.5 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
Moms and pups used in studies were fed Teklad |
50253 |
461 |
FHH-Chr 1BN/Mcwi |
serum alanine aminotransferase activity level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood alanine transaminase amount |
female |
77 days-91 days |
8 |
|
59.75 |
U/l |
3.9 |
11.03 |
standard blood chemistry panel |
|
0 |
|
Moms and pups used in studies were fed Teklad |
40740 |
401 |
FHH-Chr 1BN/Mcwi |
heart right ventricle weight to left ventricle weight ratio |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Lung data |
heart right ventricle mass |
female |
77 days-91 days |
10 |
|
0.27 |
null |
0.01 |
0.05 |
digital scale post excision weight measurement |
|
0 |
|
Moms and pups used in studies were fed Teklad |
58759 |
526 |
FHH-Chr 1BN/Mcwi |
hematocrit |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Lung data |
erythrocyte quantity |
female |
77 days-91 days |
9 |
|
55.3 |
% |
0.61 |
1.84 |
microhematocrit tube assay with visual assessment |
|
0 |
|
Moms and pups used in studies were fed Teklad |
59283 |
526 |
FHH-Chr 1BN/Mcwi |
serum phosphate level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood phosphate amount |
female |
77 days-91 days |
9 |
|
8.26 |
mg/dl |
0.26 |
0.79 |
standard blood chemistry panel |
|
0 |
|
Moms and pups used in studies were fed Teklad |
37620 |
401 |
FHH-Chr 1BN/Mcwi |
serum urea nitrogen level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood urea nitrogen amount |
male |
77 days-91 days |
13 |
|
23.15 |
mg/dl |
0.86 |
3.11 |
standard blood chemistry panel |
|
0 |
|
Moms and pups used in studies were fed Teklad |
40843 |
401 |
FHH-Chr 1BN/Mcwi |
red blood cell count |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
erythrocyte quantity |
male |
77 days-91 days |
13 |
|
9.8 |
x 10E6 cells/ul |
0.08 |
0.3 |
automated blood cell counting method |
|
0 |
|
Moms and pups used in studies were fed Teklad |
39252 |
401 |
FHH-Chr 1BN/Mcwi |
red blood cell count |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
erythrocyte quantity |
female |
77 days-91 days |
9 |
|
9.51 |
x 10E6 cells/ul |
0.1 |
0.31 |
automated blood cell counting method |
|
0 |
|
Moms and pups used in studies were fed Teklad |
39263 |
401 |
FHH-Chr 1BN/Mcwi |
serum sodium level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood sodium amount |
female |
77 days-91 days |
9 |
|
145.33 |
mmol/l |
0.44 |
1.32 |
standard blood chemistry panel |
|
0 |
|
Moms and pups used in studies were fed Teklad |
39414 |
401 |
FHH-Chr 1BN/Mcwi |
partial pressure of blood carbon dioxide (Pco2) |
controlled air oxygen content (12 %) (for 0.1 hours) |
PhysGen Respiratory data |
blood gas amount |
male |
82 days-99 days |
11 |
|
27.65 |
mmHg |
0.67 |
2.22 |
automated blood gas analysis using a Bayer analyzer |
|
0 |
|
Moms and pups used in studies were fed Teklad |
17268 |
381 |
FHH-Chr 1BN/Mcwi |
blood pH |
controlled air oxygen content (12 %) (for 0.1 hours) |
PhysGen Respiratory data |
blood acidity-alkalinity balance trait |
male |
82 days-99 days |
11 |
|
7.5 |
null |
0.01 |
0.02 |
automated blood gas analysis using a Bayer analyzer |
|
0 |
|
Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks |
17076 |
381 |
FHH-Chr 1BN/Mcwi |
percent change in respiration rate |
controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) |
PhysGen Respiratory data |
respiratory function trait |
male |
82 days-99 days |
18 |
|
122.48 |
% |
6.61 |
28.03 |
stop flow air displacement plethysmography |
|
0 |
|
Moms and pups used in studies were fed Teklad |
53771 |
381 |
FHH-Chr 1BN/Mcwi |
percent change in tidal volume |
controlled air oxygen content (12 %) (between 0 and 0.1 hours) |
PhysGen Respiratory data |
pulmonary ventilation trait |
male |
82 days-99 days |
18 |
|
115.65 |
% |
4.49 |
19.07 |
stop flow air displacement plethysmography |
|
0 |
|
Moms and pups used in studies were fed Teklad |
53903 |
381 |
FHH-Chr 1BN/Mcwi |
absolute change in blood pH |
controlled air oxygen content (12 %) (for 0.1 hours) |
PhysGen Respiratory data |
blood acidity-alkalinity balance trait |
female |
82 days-99 days |
7 |
|
0.04 |
null |
0.01 |
0.02 |
automated blood gas analysis using a Bayer analyzer |
|
0 |
|
Moms and pups used in studies were fed Teklad |
19831 |
381 |
FHH-Chr 1BN/Mcwi |
heart rate |
controlled air oxygen content (12 %) (for 0.1 hours) |
PhysGen Respiratory data |
heart pumping trait |
female |
82 days-99 days |
7 |
|
467.14 |
beats/min |
24.71 |
65.38 |
vascular fluid filled catheter |
|
0 |
|
Moms and pups used in studies were fed Teklad |
17552 |
381 |
FHH-Chr 1BN/Mcwi |
serum calcium level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood calcium amount |
male |
77 days-91 days |
15 |
|
9.12 |
mg/dl |
0.11 |
0.43 |
standard blood chemistry panel |
|
0 |
|
Moms and pups used in studies were fed Teklad |
36639 |
401 |
FHH-Chr 1BN/Mcwi |
respiration rate |
controlled air oxygen content (12 %) (between 0 and 0.1 hours) |
PhysGen Respiratory data |
respiratory function trait |
male |
82 days-99 days |
18 |
|
129.74 |
breaths/min |
5.56 |
23.59 |
stop flow air displacement plethysmography |
|
0 |
|
Moms and pups used in studies were fed Teklad |
18280 |
381 |
FHH-Chr 1BN/Mcwi |
respiration rate |
controlled air oxygen content (12 %) (between 0 and 0.1 hours) |
PhysGen Respiratory data |
respiratory function trait |
female |
82 days-99 days |
16 |
|
122.51 |
breaths/min |
6.35 |
25.4 |
stop flow air displacement plethysmography |
|
0 |
|
Moms and pups used in studies were fed Teklad |
18291 |
381 |
FHH-Chr 1BN/Mcwi |
absolute change in body temperature |
controlled air oxygen content (12 %) (for 0.1 hours) |
PhysGen Respiratory data |
body temperature trait |
female |
82 days-99 days |
15 |
|
-0.11 |
degrees C |
0.15 |
0.58 |
digital rectal thermometry |
|
0 |
|
Moms and pups used in studies were fed Teklad |
20335 |
381 |
FHH-Chr 1BN/Mcwi |
time to onset of heart contraction |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) |
PhysGen Cardiac data |
heart muscle contractility trait |
female |
49 days-63 days |
10 |
|
946.07 |
s |
60.82 |
192.34 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
Moms and pups used in studies were fed Teklad |
49325 |
461 |
FHH-Chr 1BN/Mcwi |
mean corpuscular volume |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
erythrocyte size trait |
male |
77 days-91 days |
13 |
|
58.02 |
fl |
0.58 |
2.09 |
automated blood cell counting method |
|
0 |
|
Moms and pups used in studies were fed Teklad |
38760 |
401 |
FHH-Chr 1BN/Mcwi |
serum aspartate aminotransferase activity level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood aspartate transaminase amount |
male |
77 days-91 days |
14 |
|
127.93 |
U/l |
10.54 |
39.44 |
standard blood chemistry panel |
|
0 |
|
Moms and pups used in studies were fed Teklad |
42785 |
401 |
FHH-Chr 1BN/Mcwi |
serum aspartate aminotransferase activity level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood aspartate transaminase amount |
female |
77 days-91 days |
8 |
|
80.38 |
U/l |
3.22 |
9.12 |
standard blood chemistry panel |
|
0 |
|
Moms and pups used in studies were fed Teklad |
42796 |
401 |
FHH-Chr 1BN/Mcwi |
blood hemoglobin level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood hemoglobin amount |
female |
77 days-91 days |
9 |
|
17.71 |
g/dl |
0.23 |
0.7 |
automated blood cell counting method |
|
0 |
|
Moms and pups used in studies were fed Teklad |
37994 |
401 |
FHH-Chr 1BN/Mcwi |
plasma anion gap |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
ion homeostasis trait |
female |
77 days-91 days |
9 |
|
23.67 |
mmol/l |
0.71 |
2.12 |
standard blood chemistry panel |
|
0 |
|
Moms and pups used in studies were fed Teklad |
38287 |
401 |
FHH-Chr 1BN/Mcwi |
left ventricular developed pressure |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) |
PhysGen Cardiac data |
heart left ventricular blood pressure trait |
female |
49 days-63 days |
10 |
|
146.91 |
mmHg |
5.97 |
18.87 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
Moms and pups used in studies were fed Teklad |
48650 |
461 |
FHH-Chr 1BN/Mcwi |
FAPGG metabolism-surface area product |
controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) |
PhysGen Lung data |
pulmonary blood flow trait |
male |
77 days-91 days |
12 |
|
52.21 |
ml/min/kg |
5.22 |
18.09 |
isolated perfused lung vascular effluent collection |
|
0 |
|
Moms and pups used in studies were fed Teklad |
58014 |
526 |
FHH-Chr 1BN/Mcwi |
body temperature |
controlled air oxygen content (12 %) (for 0.1 hours) |
PhysGen Respiratory data |
body temperature trait |
female |
82 days-99 days |
15 |
|
37.46 |
degrees C |
0.09 |
0.36 |
digital rectal thermometry |
|
0 |
|
Moms and pups used in studies were fed Teklad |
16598 |
381 |
FHH-Chr 1BN/Mcwi |
fractional change in blood vessel diameter per unit change in intravascular pressure |
controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) |
PhysGen Lung data |
blood vessel distensibility trait |
female |
77 days-91 days |
10 |
|
0.03 |
mmHg-1 |
0.0 |
0.01 |
fluid-filled catheter with pressure transducer in isolated perfused lung |
|
0 |
|
Moms and pups used in studies were fed Teklad |
58515 |
526 |
FHH-Chr 1BN/Mcwi |
fractional change in blood vessel diameter per unit change in intravascular pressure |
controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) |
PhysGen Lung data |
blood vessel distensibility trait |
male |
77 days-91 days |
13 |
|
0.03 |
mmHg-1 |
0.0 |
0.01 |
fluid-filled catheter with pressure transducer in isolated perfused lung |
|
0 |
|
Moms and pups used in studies were fed Teklad |
58504 |
526 |
FHH-Chr 1BN/Mcwi |
left ventricular systolic blood pressure |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) |
PhysGen Cardiac data |
heart left ventricular blood pressure trait |
male |
49 days-63 days |
10 |
|
148.32 |
mmHg |
6.53 |
20.64 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
Moms and pups used in studies were fed Teklad |
45744 |
461 |
FHH-Chr 1BN/Mcwi |
percent change in arterial blood flow rate |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) |
PhysGen Cardiac data |
arterial blood flow trait |
female |
49 days-63 days |
10 |
post-ischemic value/pre-ischemic value x 100% |
49.61 |
% |
2.83 |
8.95 |
isolated perfused heart effluent collection |
|
0 |
|
Moms and pups used in studies were fed Teklad |
47103 |
461 |
FHH-Chr 1BN/Mcwi |
left ventricular diastolic blood pressure |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) |
PhysGen Cardiac data |
heart left ventricular blood pressure trait |
male |
49 days-63 days |
10 |
|
5.18 |
mmHg |
0.28 |
0.89 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
Moms and pups used in studies were fed Teklad |
47212 |
461 |
FHH-Chr 1BN/Mcwi |
left ventricular developed pressure |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) |
PhysGen Cardiac data |
heart left ventricular blood pressure trait |
male |
49 days-63 days |
9 |
|
39.82 |
mmHg |
8.0 |
23.99 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
Moms and pups used in studies were fed Teklad |
45285 |
461 |
FHH-Chr 1BN/Mcwi |
minute ventilation |
controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) |
PhysGen Respiratory data |
pulmonary ventilation trait |
female |
82 days-99 days |
16 |
|
36.64 |
ml/min |
2.19 |
8.74 |
stop flow air displacement plethysmography |
|
0 |
|
Moms and pups used in studies were fed Teklad |
20234 |
381 |
FHH-Chr 1BN/Mcwi |
serum total protein level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood total protein amount |
male |
77 days-91 days |
15 |
|
5.69 |
g/dl |
0.07 |
0.28 |
standard blood chemistry panel |
|
0 |
|
Moms and pups used in studies were fed Teklad |
36977 |
401 |
FHH-Chr 1BN/Mcwi |
plasma creatinine level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood creatinine amount |
female |
77 days-91 days |
9 |
|
0.24 |
mg/dl |
0.03 |
0.09 |
automated plasma creatinine analysis |
|
0 |
|
Moms and pups used in studies were fed Teklad |
39602 |
401 |
FHH-Chr 1BN/Mcwi |
blood eosinophil count |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
eosinophil quantity |
male |
77 days-91 days |
13 |
|
0.03 |
x 1000 cells/ul |
0.01 |
0.04 |
automated blood cell counting method |
|
0 |
|
Moms and pups used in studies were fed Teklad |
41662 |
401 |
FHH-Chr 1BN/Mcwi |
time to onset of heart contraction |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) |
PhysGen Cardiac data |
heart muscle contractility trait |
male |
49 days-63 days |
10 |
|
900.59 |
s |
38.21 |
120.84 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
Moms and pups used in studies were fed Teklad |
49314 |
461 |
FHH-Chr 1BN/Mcwi |
mean corpuscular hemoglobin concentration |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood hemoglobin amount |
male |
77 days-91 days |
13 |
|
32.48 |
g/dl |
0.27 |
0.99 |
automated blood cell counting method |
|
0 |
|
Moms and pups used in studies were fed Teklad |
39792 |
401 |
FHH-Chr 1BN/Mcwi |
mean corpuscular hemoglobin concentration |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood hemoglobin amount |
female |
77 days-91 days |
9 |
|
32.01 |
g/dl |
0.12 |
0.37 |
automated blood cell counting method |
|
0 |
|
Moms and pups used in studies were fed Teklad |
39803 |
401 |
FHH-Chr 1BN/Mcwi |
blood neutrophil count |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
neutrophil quantity |
male |
77 days-91 days |
13 |
|
0.99 |
x 1000 cells/ul |
0.12 |
0.45 |
automated blood cell counting method |
|
0 |
|
Moms and pups used in studies were fed Teklad |
43239 |
401 |
FHH-Chr 1BN/Mcwi |
percent change in left ventricular systolic blood pressure |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) |
PhysGen Cardiac data |
heart pumping trait |
male |
49 days-63 days |
10 |
post-ischemic value/pre-ischemic value x 100% |
59.13 |
% |
8.47 |
26.78 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
Moms and pups used in studies were fed Teklad |
48771 |
461 |
FHH-Chr 1BN/Mcwi |
hematocrit |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Lung data |
erythrocyte quantity |
male |
77 days-91 days |
13 |
|
56.87 |
% |
0.59 |
2.14 |
microhematocrit tube assay with visual assessment |
|
0 |
|
Moms and pups used in studies were fed Teklad |
59272 |
526 |
FHH-Chr 1BN/Mcwi |
hematocrit |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
erythrocyte quantity |
female |
77 days-91 days |
9 |
|
55.3 |
% |
0.61 |
1.84 |
automated blood cell counting method |
|
0 |
|
Moms and pups used in studies were fed Teklad |
39017 |
401 |
FHH-Chr 1BN/Mcwi |
mean corpuscular hemoglobin |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood hemoglobin amount |
male |
77 days-91 days |
13 |
|
18.86 |
pg |
0.32 |
1.14 |
automated blood cell counting method |
|
0 |
|
Moms and pups used in studies were fed Teklad |
42560 |
401 |
FHH-Chr 1BN/Mcwi |
tidal volume |
controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) |
PhysGen Respiratory data |
pulmonary ventilation trait |
female |
82 days-99 days |
16 |
|
0.32 |
ml |
0.01 |
0.04 |
stop flow air displacement plethysmography |
|
0 |
|
Moms and pups used in studies were fed Teklad |
15259 |
381 |
FHH-Chr 1BN/Mcwi |
absolute change in blood pH |
controlled air oxygen content (12 %) (for 0.1 hours) |
PhysGen Respiratory data |
blood acidity-alkalinity balance trait |
male |
82 days-99 days |
9 |
|
0.05 |
null |
0.01 |
0.02 |
automated blood gas analysis using a Bayer analyzer |
|
0 |
|
Moms and pups used in studies were fed Teklad |
19812 |
381 |
FHH-Chr 1BN/Mcwi |
serum alkaline phosphatase activity level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood alkaline phosphatase amount |
male |
77 days-91 days |
15 |
|
390.33 |
U/l |
17.97 |
69.6 |
standard blood chemistry panel |
|
0 |
|
Moms and pups used in studies were fed Teklad |
36394 |
401 |
FHH-Chr 1BN/Mcwi |
serum alkaline phosphatase activity level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood alkaline phosphatase amount |
female |
77 days-91 days |
9 |
|
269.0 |
U/l |
8.94 |
26.82 |
standard blood chemistry panel |
|
0 |
|
Moms and pups used in studies were fed Teklad |
36405 |
401 |
FHH-Chr 1BN/Mcwi |
absolute change in partial pressure of blood oxygen |
controlled air oxygen content (12 %) (for 0.1 hours) |
PhysGen Respiratory data |
blood oxygen amount |
male |
82 days-99 days |
9 |
|
-52.62 |
mmHg |
2.5 |
7.49 |
automated blood gas analysis using a Bayer analyzer |
|
0 |
|
Moms and pups used in studies were fed Teklad |
19491 |
381 |
FHH-Chr 1BN/Mcwi |
left ventricular systolic blood pressure |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) |
PhysGen Cardiac data |
heart left ventricular blood pressure trait |
female |
49 days-63 days |
10 |
|
103.64 |
mmHg |
6.21 |
19.65 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
Moms and pups used in studies were fed Teklad |
49914 |
461 |
FHH-Chr 1BN/Mcwi |
time to peak heart contraction |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) |
PhysGen Cardiac data |
heart pumping trait |
male |
49 days-63 days |
10 |
|
1125.69 |
s |
42.89 |
135.62 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
Moms and pups used in studies were fed Teklad |
50242 |
461 |
FHH-Chr 1BN/Mcwi |
mean corpuscular volume |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
erythrocyte size trait |
female |
77 days-91 days |
9 |
|
58.19 |
fl |
0.41 |
1.24 |
automated blood cell counting method |
|
0 |
|
Moms and pups used in studies were fed Teklad |
38771 |
401 |
FHH-Chr 1BN/Mcwi |
serum bicarbonate level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood bicarbonate amount |
male |
77 days-91 days |
15 |
|
14.93 |
mmol/l |
0.48 |
1.87 |
standard blood chemistry panel |
|
0 |
|
Moms and pups used in studies were fed Teklad |
42077 |
401 |
FHH-Chr 1BN/Mcwi |
serum albumin level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood albumin amount |
female |
77 days-91 days |
9 |
|
3.78 |
g/dl |
0.04 |
0.13 |
standard blood chemistry panel |
|
0 |
|
Moms and pups used in studies were fed Teklad |
42259 |
401 |
FHH-Chr 1BN/Mcwi |
percent change in respiration rate |
controlled air oxygen content (12 %) (between 0 and 0.1 hours) |
PhysGen Respiratory data |
respiratory function trait |
female |
82 days-99 days |
16 |
|
127.3 |
% |
7.08 |
28.32 |
stop flow air displacement plethysmography |
|
0 |
|
Moms and pups used in studies were fed Teklad |
54353 |
381 |
FHH-Chr 1BN/Mcwi |
body weight |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Lung data |
body mass |
male |
77 days-91 days |
16 |
|
178.9 |
g |
3.3 |
13.1 |
whole body digital scale |
|
0 |
|
Moms and pups used in studies were fed Teklad |
59077 |
526 |
FHH-Chr 1BN/Mcwi |
serum globulin level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood globulin amount |
male |
77 days-91 days |
15 |
|
1.81 |
g/dl |
0.04 |
0.15 |
standard blood chemistry panel |
|
0 |
replaced obsolete serum globulin level term, 1/19/2016 |
Moms and pups used in studies were fed Teklad |
40565 |
401 |
FHH-Chr 1BN/Mcwi |
serum globulin level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood globulin amount |
female |
77 days-91 days |
9 |
|
1.68 |
g/dl |
0.06 |
0.17 |
standard blood chemistry panel |
|
0 |
replaced obsolete serum globulin level term, 1/19/2016 |
Moms and pups used in studies were fed Teklad |
40576 |
401 |
FHH-Chr 1BN/Mcwi |
total white blood cell count |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
leukocyte quantity |
male |
77 days-91 days |
13 |
|
5.14 |
x 1000 cells/ul |
0.51 |
1.82 |
automated blood cell counting method |
|
0 |
|
Moms and pups used in studies were fed Teklad |
40941 |
401 |
FHH-Chr 1BN/Mcwi |
percent change in left ventricular developed pressure |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) |
PhysGen Cardiac data |
heart left ventricular blood pressure trait |
female |
49 days-63 days |
10 |
post-ischemic value/pre-ischemic value x 100% |
35.97 |
% |
3.49 |
11.03 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
Moms and pups used in studies were fed Teklad |
48553 |
461 |
FHH-Chr 1BN/Mcwi |
heart effluent lactate dehydrogenase activity level normalized to heart weight |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) |
PhysGen Cardiac data |
heart lactate dehydrogenase activity |
female |
49 days-63 days |
10 |
|
0.39 |
IU/g |
0.08 |
0.27 |
isolated perfused heart effluent collection |
|
0 |
|
Moms and pups used in studies were fed Teklad |
47511 |
461 |
FHH-Chr 1BN/Mcwi |
left ventricular systolic blood pressure |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) |
PhysGen Cardiac data |
heart left ventricular blood pressure trait |
female |
49 days-63 days |
10 |
|
152.1 |
mmHg |
6.15 |
19.44 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
Moms and pups used in studies were fed Teklad |
45755 |
461 |
FHH-Chr 1BN/Mcwi |
percent change in heart rate |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) |
PhysGen Cardiac data |
heart pumping trait |
male |
49 days-63 days |
10 |
post-ischemic value/pre-ischemic value x 100% |
95.53 |
% |
9.46 |
29.91 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
Moms and pups used in studies were fed Teklad |
48310 |
461 |
FHH-Chr 1BN/Mcwi |
serum total protein level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood total protein amount |
female |
77 days-91 days |
9 |
|
5.46 |
g/dl |
0.09 |
0.26 |
standard blood chemistry panel |
|
0 |
|
Moms and pups used in studies were fed Teklad |
36988 |
401 |
FHH-Chr 1BN/Mcwi |
serum total cholesterol level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood cholesterol amount |
male |
77 days-91 days |
14 |
|
72.64 |
mg/dl |
4.1 |
15.35 |
standard blood chemistry panel |
|
0 |
|
Moms and pups used in studies were fed Teklad |
37112 |
401 |
FHH-Chr 1BN/Mcwi |
serum total cholesterol level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood cholesterol amount |
female |
77 days-91 days |
9 |
|
65.33 |
mg/dl |
2.05 |
6.16 |
standard blood chemistry panel |
|
0 |
|
Moms and pups used in studies were fed Teklad |
37123 |
401 |
FHH-Chr 1BN/Mcwi |
percent change in ventilation |
controlled air oxygen content (12 %) (between 0 and 0.1 hours) |
PhysGen Respiratory data |
pulmonary ventilation trait |
female |
82 days-99 days |
16 |
%change=VE during 2-3 min hypoxia/control during standard conditions |
135.29 |
% |
4.94 |
19.75 |
stop flow air displacement plethysmography |
|
0 |
|
Moms and pups used in studies were fed Teklad |
13706 |
381 |
FHH-Chr 1BN/Mcwi |
respiration rate |
controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) |
PhysGen Respiratory data |
respiratory function trait |
male |
82 days-99 days |
18 |
|
127.52 |
breaths/min |
6.5 |
27.56 |
stop flow air displacement plethysmography |
|
0 |
|
Moms and pups used in studies were fed Teklad |
14809 |
381 |
FHH-Chr 1BN/Mcwi |
heart weight to body weight ratio |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Cardiac data |
heart mass |
female |
49 days-63 days |
10 |
|
6.12 |
g/kg |
0.25 |
0.78 |
digital scale post excision weight measurement |
|
0 |
|
Moms and pups used in studies were fed Teklad |
45684 |
461 |
FHH-Chr 1BN/Mcwi |
arterial blood flow rate |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) |
PhysGen Cardiac data |
arterial blood flow trait |
female |
49 days-63 days |
10 |
|
15.29 |
ml/min/g |
0.72 |
2.27 |
isolated perfused heart effluent collection |
|
0 |
|
Moms and pups used in studies were fed Teklad |
46679 |
461 |
FHH-Chr 1BN/Mcwi |
arterial blood flow rate |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) |
PhysGen Cardiac data |
arterial blood flow trait |
male |
49 days-63 days |
10 |
|
7.06 |
ml/min/g |
0.69 |
2.19 |
isolated perfused heart effluent collection |
|
0 |
|
Moms and pups used in studies were fed Teklad |
44733 |
461 |
FHH-Chr 1BN/Mcwi |
blood lymphocyte count |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
lymphocyte quantity |
male |
77 days-91 days |
13 |
|
3.83 |
x 1000 cells/ul |
0.41 |
1.48 |
automated blood cell counting method |
|
0 |
|
Moms and pups used in studies were fed Teklad |
41518 |
401 |
FHH-Chr 1BN/Mcwi |
blood lymphocyte count |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
lymphocyte quantity |
female |
77 days-91 days |
9 |
|
3.22 |
x 1000 cells/ul |
0.38 |
1.13 |
automated blood cell counting method |
|
0 |
|
Moms and pups used in studies were fed Teklad |
41529 |
401 |
FHH-Chr 1BN/Mcwi |
body weight |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Lung data |
body mass |
female |
77 days-91 days |
10 |
|
163.7 |
g |
3.9 |
12.3 |
whole body digital scale |
|
0 |
|
Moms and pups used in studies were fed Teklad |
59088 |
526 |
FHH-Chr 1BN/Mcwi |
heart effluent lactate dehydrogenase activity level normalized to heart weight |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) |
PhysGen Cardiac data |
heart lactate dehydrogenase activity |
male |
49 days-63 days |
9 |
|
0.34 |
IU/g |
0.06 |
0.19 |
isolated perfused heart effluent collection |
|
0 |
|
Moms and pups used in studies were fed Teklad |
47486 |
461 |
FHH-Chr 1BN/Mcwi |
heart right ventricle weight to left ventricle weight ratio |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Lung data |
heart right ventricle mass |
male |
77 days-91 days |
16 |
|
0.31 |
null |
0.02 |
0.08 |
digital scale post excision weight measurement |
|
0 |
|
Moms and pups used in studies were fed Teklad |
58748 |
526 |
FHH-Chr 1BN/Mcwi |
calculated pulmonary vascular resistance normalized to body weight |
controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) |
PhysGen Lung data |
pulmonary blood flow trait |
male |
77 days-91 days |
13 |
|
0.14 |
mmHg x min x kg x ml-1 |
0.01 |
0.04 |
fluid-filled catheter with pressure transducer in isolated perfused lung |
|
0 |
|
Moms and pups used in studies were fed Teklad |
59562 |
526 |
FHH-Chr 1BN/Mcwi |
mean corpuscular hemoglobin |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood hemoglobin amount |
female |
77 days-91 days |
9 |
|
18.62 |
pg |
0.15 |
0.44 |
automated blood cell counting method |
|
0 |
|
Moms and pups used in studies were fed Teklad |
42571 |
401 |
FHH-Chr 1BN/Mcwi |
serum sodium level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood sodium amount |
male |
77 days-91 days |
15 |
|
146.2 |
mmol/l |
0.69 |
2.68 |
standard blood chemistry panel |
|
0 |
|
Moms and pups used in studies were fed Teklad |
39403 |
401 |
FHH-Chr 1BN/Mcwi |
serum potassium level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood potassium amount |
female |
77 days-91 days |
9 |
|
4.7 |
mmol/l |
0.15 |
0.44 |
standard blood chemistry panel |
|
0 |
|
Moms and pups used in studies were fed Teklad |
38092 |
401 |