Phenominer Database Results (372 results)

 
 
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Strain Phenotype Conditions Study Experiment Name Sex Age # of Animals Formula Value Units SEM SD Method Method Duration Post Insult Time Value Method Notes Clinical Measurement Notes Experiment Notes Record ID Study ID
FHH-Chr 14BN/Mcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 0.24 ml 0.01 0.04 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15439 381
FHH-Chr 14BN/Mcwi percent change in ventilation air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 %change=VE during 2-3 min hypoxia/control during standard conditions 141.18 % 7.7 24.34 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13722 381
FHH-Chr 14BN/Mcwi respiration rate air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 9 166.95 breaths/min 11.41 34.22 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 17153 381
FHH-Chr 14BN/Mcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 0.2 ml 0.01 0.04 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18013 381
FHH-Chr 14BN/Mcwi minute ventilation air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 37.25 ml/min 2.39 7.56 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18704 381
FHH-Chr 14BN/Mcwi serum calcium level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount female 77 days-91 days 8 9.24 mg/dl 0.16 0.46 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36655 401
FHH-Chr 14BN/Mcwi time to onset of heart contraction air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 6 965.13 s 35.13 86.06 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49340 461
FHH-Chr 14BN/Mcwi heart contraction pressure air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 6 25.83 mmHg 6.05 14.81 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50038 461
FHH-Chr 14BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 6 8.09 % 3.94 9.65 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49437 461
FHH-Chr 14BN/Mcwi mean corpuscular volume air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77 days-91 days 8 58.31 fl 0.44 1.24 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38776 401
FHH-Chr 14BN/Mcwi blood neutrophil count control condition (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77 days-91 days 8 0.49 x 1000 cells/ul 0.1 0.28 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38882 401
FHH-Chr 14BN/Mcwi serum bicarbonate level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 8 20.75 mmol/l 0.96 2.71 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42103 401
FHH-Chr 14BN/Mcwi mean corpuscular hemoglobin control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 8 17.5 pg 0.13 0.36 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40200 401
FHH-Chr 14BN/Mcwi blood monocyte count control condition (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 8 0.24 x 1000 cells/ul 0.03 0.09 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40296 401
FHH-Chr 14BN/Mcwi body weight air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass female 77 days-91 days 10 103.8 g 4.0 12.6 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59093 526
FHH-Chr 14BN/Mcwi serum potassium level control condition (for 14 days) PhysGen Biochemistry data blood potassium amount female 77 days-91 days 8 4.06 mmol/l 0.16 0.45 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 43313 401
FHH-Chr 14BN/Mcwi serum chloride level control condition (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 8 107.5 mmol/l 0.76 2.14 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40008 401
FHH-Chr 14BN/Mcwi blood lymphocyte count air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77 days-91 days 8 4.57 x 1000 cells/ul 0.44 1.24 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41534 401
FHH-Chr 14BN/Mcwi serum urea nitrogen level control condition (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77 days-91 days 8 19.38 mg/dl 1.59 4.5 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41754 401
FHH-Chr 14BN/Mcwi plasma anion gap air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77 days-91 days 8 18.0 mmol/l 1.27 3.59 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38292 401
FHH-Chr 14BN/Mcwi maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 10 1.0 g/mg 0.16 0.49 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57311 522
FHH-Chr 14BN/Mcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 23.94 ml/min 1.82 5.76 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16178 381
FHH-Chr 14BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 5 17.5 ml/min/kg 1.12 2.5 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57629 526
FHH-Chr 14BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 9 15.97 ml/min/kg 0.99 2.96 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57639 526
FHH-Chr 14BN/Mcwi body weight control condition (for 14 days) PhysGen Lung data body mass female 77 days-91 days 10 146.8 g 2.1 6.5 whole body digital scale 0 Moms and pups used in studies were fed Teklad 58324 526
FHH-Chr 14BN/Mcwi body weight control condition (for 14 days) PhysGen Lung data body mass male 77 days-91 days 10 150.6 g 10.0 31.5 whole body digital scale 0 Moms and pups used in studies were fed Teklad 58340 526
FHH-Chr 14BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 9 -7.72 null 0.06 0.18 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 56098 522
FHH-Chr 14BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 8 0.02 umol/l 0.0 0.01 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54651 522
FHH-Chr 14BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 9 0.02 umol/l 0.0 0.01 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54899 522
FHH-Chr 14BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77 days-91 days 5 0.02 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58520 526
FHH-Chr 14BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 22.05 ml/min/kg 2.81 7.94 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58625 526
FHH-Chr 14BN/Mcwi tidal volume air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 0.28 ml 0.02 0.05 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 17401 381
FHH-Chr 14BN/Mcwi tidal volume air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 0.32 ml 0.02 0.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 17412 381
FHH-Chr 14BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 4 0.39 IU/g 0.19 0.39 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47425 461
FHH-Chr 14BN/Mcwi heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 6 213.6 beats/min 8.84 21.66 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48238 461
FHH-Chr 14BN/Mcwi percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 7 post-ischemic value/pre-ischemic value x 100% 79.29 % 19.42 51.37 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46097 461
FHH-Chr 14BN/Mcwi percent change in heart rate air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 6 post-ischemic value/pre-ischemic value x 100% 92.92 % 3.0 7.34 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48336 461
FHH-Chr 14BN/Mcwi tidal volume air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 0.22 ml 0.02 0.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15264 381
FHH-Chr 14BN/Mcwi minute ventilation air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 57.71 ml/min 3.56 10.68 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14542 381
FHH-Chr 14BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount female 80 days-99 days 4 0.49 mg/dl 0.05 0.09 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52251 482
FHH-Chr 14BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data renin activity female 80 days-99 days 5 4.35 ng/ml/h 1.32 2.96 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52886 482
FHH-Chr 14BN/Mcwi mean arterial blood pressure controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data arterial blood pressure trait female 80 days-99 days 6 156.03 mmHg 5.11 12.52 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52539 482
FHH-Chr 14BN/Mcwi serum total protein level control condition (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 8 4.83 g/dl 0.1 0.28 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37200 401
FHH-Chr 14BN/Mcwi blood lymphocyte count control condition (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 8 3.37 x 1000 cells/ul 0.33 0.94 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 36871 401
FHH-Chr 14BN/Mcwi minute ventilation air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 30.53 ml/min 1.58 5.0 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20250 381
FHH-Chr 14BN/Mcwi serum chloride level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount female 77 days-91 days 8 111.63 mmol/l 0.71 2.0 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39148 401
FHH-Chr 14BN/Mcwi percent change in respiration rate air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 10 137.23 % 9.0 28.45 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54368 381
FHH-Chr 14BN/Mcwi serum bicarbonate level control condition (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 8 24.63 mmol/l 1.15 3.25 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42992 401
FHH-Chr 14BN/Mcwi blood neutrophil count air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77 days-91 days 8 0.87 x 1000 cells/ul 0.15 0.42 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43255 401
FHH-Chr 14BN/Mcwi percent change in tidal volume air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 132.48 % 10.62 33.58 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54457 381
FHH-Chr 14BN/Mcwi total white blood cell count air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77 days-91 days 8 5.71 x 1000 cells/ul 0.43 1.23 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40957 401
FHH-Chr 14BN/Mcwi serum urea nitrogen level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77 days-91 days 8 27.63 mg/dl 2.1 5.93 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40869 401
FHH-Chr 14BN/Mcwi serum glucose level control condition (for 14 days) PhysGen Biochemistry data blood glucose amount male 77 days-91 days 8 143.5 mg/dl 4.35 12.31 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41196 401
FHH-Chr 14BN/Mcwi heart wet weight air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 9 0.52 g 0.04 0.13 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45436 461
FHH-Chr 14BN/Mcwi red blood cell count control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 8 7.66 x 10E6 cells/ul 0.2 0.58 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41971 401
FHH-Chr 14BN/Mcwi maximum contractile force per wet weight of aorta potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 10 1.42 g/mg 0.14 0.44 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55781 522
FHH-Chr 14BN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 9 -7.25 null 0.1 0.3 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55618 522
FHH-Chr 14BN/Mcwi FAPGG metabolism-surface area product air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 5 59.0 ml/min/kg 5.23 11.69 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58030 526
FHH-Chr 14BN/Mcwi calculated pulmonary vascular resistance normalized to body weight Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 8 0.1 mmHg x min x kg x ml-1 0.01 0.03 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59874 526
FHH-Chr 14BN/Mcwi arterial blood flow rate air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 4 8.09 ml/min/g 1.77 3.54 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44749 461
FHH-Chr 14BN/Mcwi arterial blood flow rate air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 6 6.86 ml/min/g 0.93 2.29 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44759 461
FHH-Chr 14BN/Mcwi arterial blood flow rate air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 4 17.65 ml/min/g 3.77 7.54 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46684 461
FHH-Chr 14BN/Mcwi heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 6 182.37 beats/min 22.03 53.97 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48986 461
FHH-Chr 14BN/Mcwi respiration rate air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 171.76 breaths/min 5.11 16.15 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16942 381
FHH-Chr 14BN/Mcwi serum total cholesterol level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77 days-91 days 8 69.13 mg/dl 2.86 8.1 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37128 401
FHH-Chr 14BN/Mcwi percent change in ventilation air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 %change=VE during7-9 min hypercapnia/control during standard conditions 115.45 % 3.71 11.72 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18585 381
FHH-Chr 14BN/Mcwi heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 7 234.57 beats/min 10.62 28.09 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48228 461
FHH-Chr 14BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 6 0.68 IU/g 0.21 0.52 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47441 461
FHH-Chr 14BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 6 0.32 IU/g 0.09 0.23 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47299 461
FHH-Chr 14BN/Mcwi left ventricular developed pressure air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 6 22.9 mmHg 7.87 19.29 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45311 461
FHH-Chr 14BN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 9 -7.26 null 0.06 0.18 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55602 522
FHH-Chr 14BN/Mcwi serum total bilirubin level control condition (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77 days-91 days 8 0.1 mg/dl 0.0 0.0 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42869 401
FHH-Chr 14BN/Mcwi serum bicarbonate level control condition (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77 days-91 days 8 24.25 mmol/l 1.18 3.33 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42976 401
FHH-Chr 14BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 4 2.93 % 0.37 0.75 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49729 461
FHH-Chr 14BN/Mcwi heart wet weight air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 9 0.57 g 0.05 0.14 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45446 461
FHH-Chr 14BN/Mcwi left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 5 65.12 mmHg 6.18 13.83 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45545 461
FHH-Chr 14BN/Mcwi percent change in respiration rate air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 156.29 % 8.5 26.89 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53666 381
FHH-Chr 14BN/Mcwi heart right ventricle weight to left ventricle weight ratio control condition (for 14 days) PhysGen Lung data heart right ventricle mass female 77 days-91 days 10 0.29 null 0.01 0.04 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 57887 526
FHH-Chr 14BN/Mcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 0.21 ml 0.01 0.04 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15428 381
FHH-Chr 14BN/Mcwi urine total protein excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data total urine protein amount female 80 days-99 days 6 120.21 mg/d 42.95 105.22 automated urine total protein analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52102 482
FHH-Chr 14BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data renin activity male 80 days-99 days 7 2.19 ng/ml/h 0.69 1.83 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52902 482
FHH-Chr 14BN/Mcwi creatinine clearance controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data glomerular filtration trait male 80 days-99 days 8 1.55 ml/min 0.16 0.45 urine creatinine analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52363 482
FHH-Chr 14BN/Mcwi percent change in ventilation air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 %change=VE during7-9 min hypercapnia/control during standard conditions 200.7 % 21.27 63.81 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14240 381
FHH-Chr 14BN/Mcwi body temperature air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 9 37.33 degrees C 0.15 0.45 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 13601 381
FHH-Chr 14BN/Mcwi body weight control condition PhysGen Respiratory data body mass female 82 days-99 days 10 146.6 g 2.7 8.4 whole body digital scale 0 Moms and pups used in studies were fed Dyets 17848 381
FHH-Chr 14BN/Mcwi mean corpuscular hemoglobin concentration control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 8 33.08 g/dl 0.16 0.46 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 37314 401
FHH-Chr 14BN/Mcwi serum calcium level control condition (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 8 9.23 mg/dl 0.1 0.27 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36761 401
FHH-Chr 14BN/Mcwi time to peak heart contraction air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 6 1179.56 s 29.65 72.63 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50268 461
FHH-Chr 14BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 7 9.62 % 2.33 6.15 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49427 461
FHH-Chr 14BN/Mcwi body weight air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass female 49 days-63 days 9 84.3 g 7.4 22.1 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49495 461
FHH-Chr 14BN/Mcwi left ventricular systolic blood pressure air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 6 69.74 mmHg 11.13 27.26 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49929 461
FHH-Chr 14BN/Mcwi blood neutrophil count control condition (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77 days-91 days 8 0.78 x 1000 cells/ul 0.1 0.29 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38898 401
FHH-Chr 14BN/Mcwi body weight air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass male 77 days-91 days 10 116.3 g 5.3 16.7 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59103 526
FHH-Chr 14BN/Mcwi blood eosinophil count air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77 days-91 days 8 0.05 x 1000 cells/ul 0.02 0.06 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41688 401
FHH-Chr 14BN/Mcwi percent change in left ventricular systolic blood pressure air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 6 post-ischemic value/pre-ischemic value x 100% 92.41 % 7.05 17.26 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48797 461
FHH-Chr 14BN/Mcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 28.71 ml/min 3.65 10.96 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16189 381
FHH-Chr 14BN/Mcwi percent change in arterial blood flow rate air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 6 post-ischemic value/pre-ischemic value x 100% 53.84 % 4.3 10.53 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47118 461
FHH-Chr 14BN/Mcwi left ventricular diastolic blood pressure air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 4 4.82 mmHg 0.35 0.7 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47228 461
FHH-Chr 14BN/Mcwi left ventricular diastolic blood pressure air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 6 5.25 mmHg 0.32 0.79 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47238 461
FHH-Chr 14BN/Mcwi percent change in left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 6 post-ischemic value/pre-ischemic value x 100% 131.7 % 10.98 26.89 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 44959 461
FHH-Chr 14BN/Mcwi respiration rate control condition PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 111.4 breaths/min 3.74 11.84 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14966 381
FHH-Chr 14BN/Mcwi percent change in tidal volume air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 110.08 % 5.25 16.59 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54018 381
FHH-Chr 14BN/Mcwi percent change in respiration rate air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 139.4 % 5.89 18.63 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54251 381
FHH-Chr 14BN/Mcwi percent change in ventilation air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 %change=VE during 2-3 min hypoxia/control during standard conditions 138.21 % 7.13 22.54 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13711 381
FHH-Chr 14BN/Mcwi tidal volume air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 0.21 ml 0.02 0.05 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13954 381
FHH-Chr 14BN/Mcwi respiration rate air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 153.99 breaths/min 5.03 15.9 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 17142 381
FHH-Chr 14BN/Mcwi percent change in respiration rate air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 104.41 % 4.44 14.05 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53785 381
FHH-Chr 14BN/Mcwi respiration rate control condition PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 129.31 breaths/min 5.24 16.58 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18441 381
FHH-Chr 14BN/Mcwi heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 7 226.57 beats/min 14.2 37.57 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48976 461
FHH-Chr 14BN/Mcwi minute ventilation air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 29.87 ml/min 3.14 9.94 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20239 381
FHH-Chr 14BN/Mcwi serum aspartate aminotransferase activity level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 8 112.0 U/l 9.98 28.22 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42811 401
FHH-Chr 14BN/Mcwi plasma creatinine level control condition (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77 days-91 days 8 0.2 mg/dl 0.0 0.0 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 42632 401
FHH-Chr 14BN/Mcwi total white blood cell count control condition (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 8 4.43 x 1000 cells/ul 0.45 1.27 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39887 401
FHH-Chr 14BN/Mcwi percent change in tidal volume air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 135.9 % 7.5 22.49 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54467 381
FHH-Chr 14BN/Mcwi serum total bilirubin level control condition (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 8 0.1 mg/dl 0.0 0.0 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42885 401
FHH-Chr 14BN/Mcwi serum alanine aminotransferase activity level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 8 97.25 U/l 9.68 27.38 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40755 401
FHH-Chr 14BN/Mcwi serum globulin level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 8 1.76 g/dl 0.05 0.13 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40591 401
FHH-Chr 14BN/Mcwi lung dry weight to body weight ratio control condition (for 14 days) PhysGen Lung data lung mass female 77 days-91 days 10 1.06 g/kg 0.02 0.06 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59440 526
FHH-Chr 14BN/Mcwi serum phosphate level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77 days-91 days 8 10.54 mg/dl 0.54 1.52 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37625 401
FHH-Chr 14BN/Mcwi serum phosphate level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 8 9.19 mg/dl 0.38 1.08 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37635 401
FHH-Chr 14BN/Mcwi serum alanine aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77 days-91 days 8 68.38 U/l 5.11 14.46 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37693 401
FHH-Chr 14BN/Mcwi serum urea nitrogen level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77 days-91 days 8 29.75 mg/dl 2.6 7.36 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40859 401
FHH-Chr 14BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 7 0.51 null 0.06 0.15 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 59759 526
FHH-Chr 14BN/Mcwi blood hemoglobin level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 8 16.99 g/dl 0.39 1.1 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38009 401
FHH-Chr 14BN/Mcwi serum alanine aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 8 78.75 U/l 4.51 12.76 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37709 401
FHH-Chr 14BN/Mcwi left ventricular diastolic blood pressure air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 4 41.83 mmHg 5.18 10.36 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46448 461
FHH-Chr 14BN/Mcwi serum glucose level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount female 77 days-91 days 7 136.14 mg/dl 3.73 9.87 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38561 401
FHH-Chr 14BN/Mcwi time to peak heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 7 1315.29 s 94.82 250.87 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46579 461
FHH-Chr 14BN/Mcwi heart right ventricle weight to left ventricle weight ratio control condition (for 14 days) PhysGen Lung data heart right ventricle mass male 77 days-91 days 10 0.31 null 0.01 0.04 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 57903 526
FHH-Chr 14BN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 10 78.0 % 13.32 42.13 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54757 522
FHH-Chr 14BN/Mcwi heart contraction pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 7 38.0 mmHg 9.49 25.11 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48064 461
FHH-Chr 14BN/Mcwi left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 7 75.58 mmHg 5.73 15.16 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 44846 461
FHH-Chr 14BN/Mcwi left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 7 63.82 mmHg 7.85 20.78 balloon tipped catheter with pressure transducer in isolated perfused heart 0 46781 461
FHH-Chr 14BN/Mcwi body weight control condition PhysGen Cardiac data body mass male 49 days-63 days 9 135.7 g 11.2 33.5 whole body digital scale 0 Moms and pups used in studies were fed Teklad 47806 461
FHH-Chr 14BN/Mcwi urine sodium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine sodium amount male 80 days-99 days 7 30.48 mEq/d 3.7 9.8 flame atomic emission spectrometry 0 Moms were fed Teklad, pups used in studies were fed Dyets 52804 482
FHH-Chr 14BN/Mcwi percent change in left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 6 post-ischemic value/pre-ischemic value x 100% 88.12 % 12.72 31.15 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46360 461
FHH-Chr 14BN/Mcwi left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 7 36.54 mmHg 4.8 12.69 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47732 461
FHH-Chr 14BN/Mcwi percent change in left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 7 post-ischemic value/pre-ischemic value x 100% 114.09 % 9.53 25.22 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 44949 461
FHH-Chr 14BN/Mcwi maximum contractile force per wet weight of aorta potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 7 1.5 g/mg 0.18 0.48 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55765 522
FHH-Chr 14BN/Mcwi left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 7 68.7 mmHg 7.25 19.19 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45535 461
FHH-Chr 14BN/Mcwi left ventricular developed pressure air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 4 82.31 mmHg 13.08 26.17 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48655 461
FHH-Chr 14BN/Mcwi left ventricular diastolic blood pressure air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 6 46.84 mmHg 6.37 15.61 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46458 461
FHH-Chr 14BN/Mcwi lung dry weight to body weight ratio control condition (for 14 days) PhysGen Lung data lung mass male 77 days-91 days 10 1.1 g/kg 0.06 0.18 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59456 526
FHH-Chr 14BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 7 17.62 IU/g 1.46 3.85 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 48841 461
FHH-Chr 14BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 10 -7.73 null 0.06 0.18 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 55268 522
FHH-Chr 14BN/Mcwi lung dry weight to body weight ratio air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass male 77 days-91 days 10 1.55 g/kg 0.02 0.07 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59698 526
FHH-Chr 14BN/Mcwi FAPGG metabolism-surface area product air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 9 53.12 ml/min/kg 3.89 11.67 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58040 526
FHH-Chr 14BN/Mcwi serum potassium level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount female 77 days-91 days 8 4.61 mmol/l 0.36 1.01 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38097 401
FHH-Chr 14BN/Mcwi percent change in tidal volume air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 134.31 % 5.1 16.12 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54117 381
FHH-Chr 14BN/Mcwi percent change in tidal volume air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 144.3 % 8.49 25.48 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54127 381
FHH-Chr 14BN/Mcwi tidal volume air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 0.22 ml 0.01 0.04 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13965 381
FHH-Chr 14BN/Mcwi minute ventilation air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 42.62 ml/min 2.81 8.9 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20792 381
FHH-Chr 14BN/Mcwi serum alkaline phosphatase activity level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77 days-91 days 8 394.63 U/l 23.83 67.4 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36410 401
FHH-Chr 14BN/Mcwi respiration rate air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 10 172.82 breaths/min 12.66 40.03 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18307 381
FHH-Chr 14BN/Mcwi serum total protein level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 8 4.74 g/dl 0.12 0.34 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37003 401
FHH-Chr 14BN/Mcwi serum total cholesterol level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 8 68.25 mg/dl 4.17 11.79 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37138 401
FHH-Chr 14BN/Mcwi mean corpuscular hemoglobin concentration control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 8 33.33 g/dl 0.18 0.5 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 37330 401
FHH-Chr 14BN/Mcwi serum calcium level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 8 8.85 mg/dl 0.12 0.33 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36665 401
FHH-Chr 14BN/Mcwi heart contraction pressure air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 4 17.5 mmHg 4.09 8.19 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50028 461
FHH-Chr 14BN/Mcwi hematocrit air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 8 51.7 % 1.2 3.4 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39022 401
FHH-Chr 14BN/Mcwi hematocrit air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 8 53.45 % 1.15 3.24 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39032 401
FHH-Chr 14BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 7 2.25 mg/kg 0.56 1.49 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59151 526
FHH-Chr 14BN/Mcwi serum chloride level control condition (for 14 days) PhysGen Biochemistry data blood chloride amount female 77 days-91 days 8 106.75 mmol/l 0.7 1.98 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39992 401
FHH-Chr 14BN/Mcwi percent change in respiration rate air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 9 149.55 % 10.45 31.36 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53676 381
FHH-Chr 14BN/Mcwi serum glucose level control condition (for 14 days) PhysGen Biochemistry data blood glucose amount female 77 days-91 days 8 140.38 mg/dl 3.95 11.19 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41180 401
FHH-Chr 14BN/Mcwi serum potassium level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 8 5.15 mmol/l 0.24 0.69 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38107 401
FHH-Chr 14BN/Mcwi calculated pulmonary vascular resistance normalized to body weight air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 9 0.14 mmHg x min x kg x ml-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59588 526
FHH-Chr 14BN/Mcwi hematocrit control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 8 40.2 % 0.95 2.69 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41304 401
FHH-Chr 14BN/Mcwi serum globulin level control condition (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 8 1.84 g/dl 0.04 0.11 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 41029 401
FHH-Chr 14BN/Mcwi mean corpuscular volume control condition (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77 days-91 days 8 53.88 fl 0.17 0.47 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38633 401
FHH-Chr 14BN/Mcwi mean corpuscular volume control condition (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 8 52.49 fl 0.22 0.63 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38649 401
FHH-Chr 14BN/Mcwi red blood cell count control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 8 7.38 x 10E6 cells/ul 0.17 0.49 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41955 401
FHH-Chr 14BN/Mcwi body weight control condition (for 21 days) PhysGen Vascular data body mass male 70 days-84 days 10 130.5 g 6.8 21.6 whole body digital scale 0 Moms and pups used in studies were fed Teklad 55410 522
FHH-Chr 14BN/Mcwi body temperature air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 10 37.31 degrees C 0.18 0.57 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16614 381
FHH-Chr 14BN/Mcwi heart right ventricle weight to left ventricle weight ratio air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass male 77 days-91 days 10 0.48 null 0.02 0.06 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58774 526
FHH-Chr 14BN/Mcwi body weight controlled sodium content diet (4 %) (for 21 days) PhysGen Vascular data body mass female 70 days-84 days 10 144.4 g 7.2 22.7 whole body digital scale 0 Moms and pups used in studies were fed Teklad 55162 522
FHH-Chr 14BN/Mcwi body weight controlled sodium content diet (4 %) (for 21 days) PhysGen Vascular data body mass male 70 days-84 days 10 168.7 g 5.4 17.2 whole body digital scale 0 Moms and pups used in studies were fed Teklad 55176 522
FHH-Chr 14BN/Mcwi calculated pulmonary vascular resistance normalized to body weight Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 0.12 mmHg x min x kg x ml-1 0.01 0.03 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59890 526
FHH-Chr 14BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 4 15.19 IU/g 1.83 3.66 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45952 461
FHH-Chr 14BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 6 15.63 IU/g 1.38 3.38 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45962 461
FHH-Chr 14BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 7 8.16 ml/min/g 0.29 0.78 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46901 461
FHH-Chr 14BN/Mcwi left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 5 60.93 mmHg 6.18 13.83 balloon tipped catheter with pressure transducer in isolated perfused heart 0 46791 461
FHH-Chr 14BN/Mcwi left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 6 76.59 mmHg 8.35 20.46 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 44856 461
FHH-Chr 14BN/Mcwi left ventricular systolic blood pressure air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 4 87.13 mmHg 12.99 25.99 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45760 461
FHH-Chr 14BN/Mcwi arterial blood flow rate air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 8 12.66 ml/min/g 1.06 2.99 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46694 461
FHH-Chr 14BN/Mcwi left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 6 28.17 mmHg 4.32 10.57 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47742 461
FHH-Chr 14BN/Mcwi tidal volume air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 0.21 ml 0.01 0.04 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15275 381
FHH-Chr 14BN/Mcwi absolute change in body temperature air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 9 0.24 degrees C 0.08 0.23 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 15711 381
FHH-Chr 14BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount male 80 days-99 days 8 0.43 mg/dl 0.02 0.06 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52267 482
FHH-Chr 14BN/Mcwi creatinine clearance controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data glomerular filtration trait female 80 days-99 days 4 1.09 ml/min 0.1 0.21 urine creatinine analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52347 482
FHH-Chr 14BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine albumin amount male 80 days-99 days 8 139.15 mg/d 34.34 97.13 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52410 482
FHH-Chr 14BN/Mcwi body weight control condition PhysGen Respiratory data body mass male 82 days-99 days 10 217.9 g 8.7 27.6 whole body digital scale 0 Moms and pups used in studies were fed Dyets 17859 381
FHH-Chr 14BN/Mcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 0.21 ml 0.01 0.03 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18024 381
FHH-Chr 14BN/Mcwi heart wet weight control condition PhysGen Cardiac data heart mass female 49 days-63 days 9 0.69 g 0.04 0.13 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49091 461
FHH-Chr 14BN/Mcwi heart wet weight control condition PhysGen Cardiac data heart mass male 49 days-63 days 9 0.7 g 0.08 0.23 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49101 461
FHH-Chr 14BN/Mcwi left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 5 4.19 mmHg 0.31 0.7 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49218 461
FHH-Chr 14BN/Mcwi percent change in ventilation air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 %change=VE during 2-3 min hypercapnia/control during standard conditions 217.4 % 22.08 66.25 stop flow air displacement plethysmography 0 0 Moms and pups used in studies were fed Teklad 19253 381
FHH-Chr 14BN/Mcwi respiration rate air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 169.41 breaths/min 8.23 26.03 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18296 381
FHH-Chr 14BN/Mcwi absolute change in body temperature air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 10 0.16 degrees C 0.16 0.51 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20340 381
FHH-Chr 14BN/Mcwi serum sodium level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount female 77 days-91 days 8 145.63 mmol/l 0.46 1.3 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39419 401
FHH-Chr 14BN/Mcwi mean corpuscular hemoglobin air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 8 18.64 pg 0.08 0.21 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42576 401
FHH-Chr 14BN/Mcwi red blood cell count air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 8 9.28 x 10E6 cells/ul 0.25 0.7 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39278 401
FHH-Chr 14BN/Mcwi total white blood cell count control condition (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77 days-91 days 8 3.95 x 1000 cells/ul 0.3 0.84 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39871 401
FHH-Chr 14BN/Mcwi percent change in respiration rate air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 131.67 % 5.51 17.41 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54358 381
FHH-Chr 14BN/Mcwi plasma anion gap control condition (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 8 15.75 mmol/l 0.45 1.28 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 43133 401
FHH-Chr 14BN/Mcwi blood neutrophil count air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77 days-91 days 8 1.11 x 1000 cells/ul 0.15 0.43 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43265 401
FHH-Chr 14BN/Mcwi plasma creatinine level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 8 0.3 mg/dl 0.03 0.08 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39617 401
FHH-Chr 14BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77 days-91 days 8 0.05 mmHg-1 0.01 0.03 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59344 526
FHH-Chr 14BN/Mcwi serum alanine aminotransferase activity level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77 days-91 days 8 83.38 U/l 4.4 12.43 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40745 401
FHH-Chr 14BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 25.55 ml/min/kg 2.46 6.96 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57841 526
FHH-Chr 14BN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 9 -6.92 null 0.13 0.4 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56908 522
FHH-Chr 14BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 6 5.07 ml/min/g 0.68 1.68 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46242 461
FHH-Chr 14BN/Mcwi percent change in heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 6 post-ischemic value/pre-ischemic value x 100% 84.53 % 8.95 21.93 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48447 461
FHH-Chr 14BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 7 0.36 IU/g 0.07 0.19 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47283 461
FHH-Chr 14BN/Mcwi heart rate air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 6 204.34 beats/min 11.08 27.13 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45189 461
FHH-Chr 14BN/Mcwi respiration rate air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 9 170.5 breaths/min 6.62 19.85 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16953 381
FHH-Chr 14BN/Mcwi serum total protein level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 8 4.78 g/dl 0.1 0.29 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36993 401
FHH-Chr 14BN/Mcwi percent change in ventilation air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 %change=VE during 2-3 min hypercapnia/control during standard conditions 208.68 % 11.33 35.82 stop flow air displacement plethysmography 0 0 Moms and pups used in studies were fed Teklad 19242 381
FHH-Chr 14BN/Mcwi heart weight to body weight ratio air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 9 6.5 g/kg 0.53 1.58 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45609 461
FHH-Chr 14BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 6 7.57 ml/min/g 0.52 1.28 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46911 461
FHH-Chr 14BN/Mcwi serum aspartate aminotransferase activity level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77 days-91 days 8 96.25 U/l 3.6 10.19 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42801 401
FHH-Chr 14BN/Mcwi tidal volume air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 0.28 ml 0.01 0.03 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16504 381
FHH-Chr 14BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 10 0.58 E-7mole 0.08 0.25 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55871 522
FHH-Chr 14BN/Mcwi heart weight to body weight ratio air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 9 6.28 g/kg 0.43 1.28 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45593 461
FHH-Chr 14BN/Mcwi percent change in left ventricular systolic blood pressure air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 4 post-ischemic value/pre-ischemic value x 100% 79.11 % 8.13 16.25 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48787 461
FHH-Chr 14BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 8 0.04 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59360 526
FHH-Chr 14BN/Mcwi red blood cell count air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 8 8.87 x 10E6 cells/ul 0.21 0.61 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39268 401
FHH-Chr 14BN/Mcwi hematocrit control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 8 39.74 % 0.97 2.75 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41288 401
FHH-Chr 14BN/Mcwi minute ventilation air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 48.67 ml/min 2.35 7.44 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14531 381
FHH-Chr 14BN/Mcwi urine total protein excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data total urine protein amount male 80 days-99 days 8 260.83 mg/d 72.11 203.96 automated urine total protein analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52118 482
FHH-Chr 14BN/Mcwi urine potassium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine potassium amount male 80 days-99 days 8 2.67 mEq/d 0.79 2.22 flame atomic emission spectrometry 0 urine potassium analysis Moms were fed Teklad, pups used in studies were fed Dyets 52316 482
FHH-Chr 14BN/Mcwi body temperature air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 10 37.27 degrees C 0.17 0.54 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 13590 381
FHH-Chr 14BN/Mcwi serum alkaline phosphatase activity level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 8 405.75 U/l 24.89 70.41 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36420 401
FHH-Chr 14BN/Mcwi serum total protein level control condition (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 8 4.89 g/dl 0.1 0.28 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37184 401
FHH-Chr 14BN/Mcwi mean corpuscular hemoglobin air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 8 18.31 pg 0.12 0.33 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42586 401
FHH-Chr 14BN/Mcwi blood monocyte count air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity female 77 days-91 days 8 0.22 x 1000 cells/ul 0.05 0.15 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39705 401
FHH-Chr 14BN/Mcwi mean corpuscular hemoglobin concentration air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 8 31.75 g/dl 0.16 0.45 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39818 401
FHH-Chr 14BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 6 4.44 mg/kg 1.7 4.17 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58937 526
FHH-Chr 14BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 0.56 null 0.05 0.15 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 59775 526
FHH-Chr 14BN/Mcwi serum phosphate level control condition (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77 days-91 days 8 8.88 mg/dl 0.28 0.8 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37813 401
FHH-Chr 14BN/Mcwi serum phosphate level control condition (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 8 8.86 mg/dl 0.25 0.71 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37829 401
FHH-Chr 14BN/Mcwi calculated pulmonary vascular resistance normalized to body weight air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 5 0.14 mmHg x min x kg x ml-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59578 526
FHH-Chr 14BN/Mcwi lung dry weight to body weight ratio air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass female 77 days-91 days 9 1.81 g/kg 0.09 0.27 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59688 526
FHH-Chr 14BN/Mcwi percent change in left ventricular developed pressure air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 6 post-ischemic value/pre-ischemic value x 100% 32.87 % 7.74 18.97 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48568 461
FHH-Chr 14BN/Mcwi serum total bilirubin level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77 days-91 days 8 0.11 mg/dl 0.01 0.04 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41899 401
FHH-Chr 14BN/Mcwi percent change in left ventricular developed pressure air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 4 post-ischemic value/pre-ischemic value x 100% 32.27 % 6.26 12.53 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48558 461
FHH-Chr 14BN/Mcwi serum glucose level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount male 77 days-91 days 8 152.63 mg/dl 8.09 22.87 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38571 401
FHH-Chr 14BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 10 0.01 umol/l 0.0 0.01 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54883 522
FHH-Chr 14BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 9 0.02 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58530 526
FHH-Chr 14BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 9 1.74 E-7mole 0.66 1.98 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56513 522
FHH-Chr 14BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 7 3.38 mg/kg 0.87 2.31 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58947 526
FHH-Chr 14BN/Mcwi heart weight to body weight ratio control condition PhysGen Cardiac data heart mass male 49 days-63 days 9 5.13 g/kg 0.18 0.55 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 46984 461
FHH-Chr 14BN/Mcwi left ventricular systolic blood pressure air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 6 77.74 mmHg 12.99 31.81 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45770 461
FHH-Chr 14BN/Mcwi left ventricular developed pressure air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 4 24.32 mmHg 2.27 4.55 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45301 461
FHH-Chr 14BN/Mcwi percent change in respiration rate air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 9 146.97 % 13.37 40.1 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54261 381
FHH-Chr 14BN/Mcwi minute ventilation air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 53.14 ml/min 3.79 11.36 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20803 381
FHH-Chr 14BN/Mcwi percent change in respiration rate air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 10 120.57 % 6.67 21.1 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53795 381
FHH-Chr 14BN/Mcwi body temperature control condition PhysGen Respiratory data body temperature trait male 82 days-99 days 9 37.09 degrees C 0.13 0.39 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 19111 381
FHH-Chr 14BN/Mcwi serum calcium level control condition (for 14 days) PhysGen Biochemistry data blood calcium amount female 77 days-91 days 8 9.51 mg/dl 0.13 0.36 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36745 401
FHH-Chr 14BN/Mcwi minute ventilation air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 35.66 ml/min 3.32 10.48 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18693 381
FHH-Chr 14BN/Mcwi time to onset of heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 7 1119.29 s 74.89 198.15 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50150 461
FHH-Chr 14BN/Mcwi serum aspartate aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77 days-91 days 8 91.25 U/l 6.68 18.88 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42403 401
FHH-Chr 14BN/Mcwi serum albumin level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount female 77 days-91 days 8 3.06 g/dl 0.05 0.15 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42264 401
FHH-Chr 14BN/Mcwi serum globulin level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount female 77 days-91 days 8 1.71 g/dl 0.05 0.16 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40581 401
FHH-Chr 14BN/Mcwi hematocrit air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity female 77 days-91 days 8 51.7 % 1.2 3.4 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59288 526
FHH-Chr 14BN/Mcwi serum total cholesterol level control condition (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 8 81.13 mg/dl 2.51 7.1 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38435 401
FHH-Chr 14BN/Mcwi blood lymphocyte count air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 8 4.72 x 1000 cells/ul 0.41 1.17 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41544 401
FHH-Chr 14BN/Mcwi plasma anion gap air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 8 17.25 mmol/l 0.53 1.49 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38302 401
FHH-Chr 14BN/Mcwi blood eosinophil count air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77 days-91 days 8 0.05 x 1000 cells/ul 0.02 0.06 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41678 401
FHH-Chr 14BN/Mcwi hematocrit control condition (for 14 days) PhysGen Lung data erythrocyte quantity male 77 days-91 days 8 40.2 % 0.95 2.69 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 57489 526
FHH-Chr 14BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 5 28.69 ml/min/kg 2.06 4.61 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57831 526
FHH-Chr 14BN/Mcwi body temperature control condition PhysGen Respiratory data body temperature trait female 82 days-99 days 10 37.19 degrees C 0.16 0.5 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16843 381
FHH-Chr 14BN/Mcwi body temperature control condition PhysGen Respiratory data body temperature trait male 82 days-99 days 10 37.27 degrees C 0.16 0.49 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16854 381
FHH-Chr 14BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 5 0.49 null 0.03 0.07 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58144 526
FHH-Chr 14BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 0.47 null 0.05 0.15 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58154 526
FHH-Chr 14BN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 10 -6.83 null 0.09 0.27 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56892 522
FHH-Chr 14BN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 9 76.89 % 4.4 13.19 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57217 522
FHH-Chr 14BN/Mcwi percent change in heart rate air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 4 post-ischemic value/pre-ischemic value x 100% 102.69 % 11.67 23.35 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48326 461
FHH-Chr 14BN/Mcwi percent change in arterial blood flow rate air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 4 post-ischemic value/pre-ischemic value x 100% 49.03 % 9.9 19.8 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47108 461
FHH-Chr 14BN/Mcwi body temperature control condition PhysGen Respiratory data body temperature trait female 82 days-99 days 10 37.1 degrees C 0.18 0.57 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 19100 381
FHH-Chr 14BN/Mcwi percent change in ventilation air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 %change=VE during7-9 min hypercapnia/control during standard conditions 115.69 % 8.82 27.89 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18574 381
FHH-Chr 14BN/Mcwi heart rate air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 4 213.13 beats/min 13.85 27.7 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45179 461
FHH-Chr 14BN/Mcwi percent change in heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 7 post-ischemic value/pre-ischemic value x 100% 96.86 % 5.42 14.33 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48437 461
FHH-Chr 14BN/Mcwi body temperature air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 10 37.35 degrees C 0.22 0.71 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16603 381
FHH-Chr 14BN/Mcwi plasma creatinine level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77 days-91 days 8 0.26 mg/dl 0.03 0.07 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39607 401
FHH-Chr 14BN/Mcwi blood monocyte count air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 8 0.27 x 1000 cells/ul 0.07 0.19 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39715 401
FHH-Chr 14BN/Mcwi body weight air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass male 49 days-63 days 9 88.4 g 6.0 18.1 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49511 461
FHH-Chr 14BN/Mcwi heart rate air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 8 213.22 beats/min 17.47 49.41 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47623 461
FHH-Chr 14BN/Mcwi blood monocyte count control condition (for 14 days) PhysGen Biochemistry data monocyte quantity female 77 days-91 days 8 0.1 x 1000 cells/ul 0.02 0.06 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40280 401
FHH-Chr 14BN/Mcwi time to onset of heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 6 1121.33 s 87.97 215.49 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50160 461
FHH-Chr 14BN/Mcwi heart right ventricle weight to left ventricle weight ratio air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass female 77 days-91 days 10 0.53 null 0.02 0.08 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58764 526
FHH-Chr 14BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 10 1.76 E-7mole 0.37 1.18 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56497 522
FHH-Chr 14BN/Mcwi left ventricular developed pressure air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 6 72.49 mmHg 13.13 32.16 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48665 461
FHH-Chr 14BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 6 16.96 IU/g 0.69 1.68 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 48852 461
FHH-Chr 14BN/Mcwi serum bicarbonate level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77 days-91 days 8 20.75 mmol/l 0.65 1.83 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42093 401
FHH-Chr 14BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 8 -7.75 null 0.06 0.17 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 55252 522
FHH-Chr 14BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 11.68 ml/min/kg 1.37 3.88 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 59996 526
FHH-Chr 14BN/Mcwi percent change in tidal volume air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 105.24 % 4.43 14.02 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53917 381
FHH-Chr 14BN/Mcwi respiration rate control condition PhysGen Respiratory data respiratory function trait male 82 days-99 days 10 126.53 breaths/min 5.64 17.83 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18452 381
FHH-Chr 14BN/Mcwi left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 7 4.89 mmHg 0.72 1.91 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49208 461
FHH-Chr 14BN/Mcwi absolute change in body temperature air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 10 0.04 degrees C 0.12 0.37 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20351 381
FHH-Chr 14BN/Mcwi serum sodium level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 8 145.0 mmol/l 0.68 1.93 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39429 401
FHH-Chr 14BN/Mcwi plasma creatinine level control condition (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 8 0.2 mg/dl 0.0 0.0 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 42648 401
FHH-Chr 14BN/Mcwi plasma anion gap control condition (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77 days-91 days 8 15.63 mmol/l 0.63 1.77 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 43117 401
FHH-Chr 14BN/Mcwi mean corpuscular hemoglobin concentration air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 8 31.96 g/dl 0.17 0.48 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39808 401
FHH-Chr 14BN/Mcwi hematocrit air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77 days-91 days 8 53.45 % 1.15 3.24 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59298 526
FHH-Chr 14BN/Mcwi total white blood cell count air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 8 6.15 x 1000 cells/ul 0.49 1.38 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40967 401
FHH-Chr 14BN/Mcwi serum total cholesterol level control condition (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77 days-91 days 8 79.63 mg/dl 2.11 5.97 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38419 401
FHH-Chr 14BN/Mcwi serum urea nitrogen level control condition (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77 days-91 days 8 18.75 mg/dl 2.04 5.78 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41738 401
FHH-Chr 14BN/Mcwi maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 10 1.18 g/mg 0.12 0.39 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57327 522
FHH-Chr 14BN/Mcwi hematocrit control condition (for 14 days) PhysGen Lung data erythrocyte quantity female 77 days-91 days 8 39.74 % 0.97 2.75 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 57473 526
FHH-Chr 14BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 10 0.61 E-7mole 0.09 0.27 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55887 522
FHH-Chr 14BN/Mcwi FAPGG metabolism-surface area product FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 40.15 ml/min/kg 5.45 15.41 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58229 526
FHH-Chr 14BN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 9 73.11 % 3.67 11.01 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57201 522
FHH-Chr 14BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 7 6.74 ml/min/g 1.98 5.24 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46232 461
FHH-Chr 14BN/Mcwi respiration rate control condition PhysGen Respiratory data respiratory function trait male 82 days-99 days 9 117.53 breaths/min 7.75 23.26 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14977 381
FHH-Chr 14BN/Mcwi absolute change in body temperature air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 10 0.17 degrees C 0.06 0.2 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 15700 381
FHH-Chr 14BN/Mcwi urine sodium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine sodium amount female 80 days-99 days 6 23.14 mEq/d 3.44 8.42 flame atomic emission spectrometry 0 Moms were fed Teklad, pups used in studies were fed Dyets 52788 482
FHH-Chr 14BN/Mcwi urine potassium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine potassium amount female 80 days-99 days 6 2.0 mEq/d 0.31 0.75 flame atomic emission spectrometry 0 urine potassium analysis Moms were fed Teklad, pups used in studies were fed Dyets 52300 482
FHH-Chr 14BN/Mcwi heart rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data heart pumping trait female 80 days-99 days 6 424.87 beats/min 7.24 17.73 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52492 482
FHH-Chr 14BN/Mcwi heart rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data heart pumping trait male 80 days-99 days 8 405.62 beats/min 14.94 42.25 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52508 482
FHH-Chr 14BN/Mcwi mean arterial blood pressure controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data arterial blood pressure trait male 80 days-99 days 8 164.54 mmHg 7.86 22.23 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52555 482
FHH-Chr 14BN/Mcwi percent change in ventilation air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 %change=VE during7-9 min hypercapnia/control during standard conditions 184.56 % 16.96 53.64 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14229 381
FHH-Chr 14BN/Mcwi blood lymphocyte count control condition (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77 days-91 days 8 3.29 x 1000 cells/ul 0.26 0.72 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 36855 401
FHH-Chr 14BN/Mcwi serum alkaline phosphatase activity level control condition (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77 days-91 days 8 245.63 U/l 16.79 47.48 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37436 401
FHH-Chr 14BN/Mcwi serum sodium level control condition (for 14 days) PhysGen Biochemistry data blood sodium amount female 77 days-91 days 8 142.63 mmol/l 0.73 2.07 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36476 401
FHH-Chr 14BN/Mcwi serum sodium level control condition (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 8 143.63 mmol/l 0.98 2.77 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36492 401
FHH-Chr 14BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 5 3.86 % 0.78 1.75 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49739 461
FHH-Chr 14BN/Mcwi time to peak heart contraction air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 4 1097.42 s 143.23 286.45 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50258 461
FHH-Chr 14BN/Mcwi time to onset of heart contraction air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 4 917.38 s 158.14 316.27 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49330 461
FHH-Chr 14BN/Mcwi mean corpuscular volume air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 8 57.73 fl 0.38 1.08 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38786 401
FHH-Chr 14BN/Mcwi serum albumin level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 8 2.98 g/dl 0.1 0.29 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42274 401
FHH-Chr 14BN/Mcwi serum aspartate aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 8 99.5 U/l 5.6 15.85 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42419 401
FHH-Chr 14BN/Mcwi serum potassium level control condition (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 8 4.21 mmol/l 0.18 0.51 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 43329 401
FHH-Chr 14BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 8 2.17 mg/kg 0.56 1.58 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59167 526
FHH-Chr 14BN/Mcwi serum albumin level control condition (for 14 days) PhysGen Biochemistry data blood albumin amount female 77 days-91 days 8 3.14 g/dl 0.08 0.23 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40393 401
FHH-Chr 14BN/Mcwi serum albumin level control condition (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 8 2.99 g/dl 0.08 0.24 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40409 401
FHH-Chr 14BN/Mcwi blood hemoglobin level control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 8 13.15 g/dl 0.28 0.8 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40088 401
FHH-Chr 14BN/Mcwi blood hemoglobin level control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 8 13.39 g/dl 0.29 0.82 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40104 401
FHH-Chr 14BN/Mcwi blood hemoglobin level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 8 16.52 g/dl 0.41 1.15 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 37999 401
FHH-Chr 14BN/Mcwi blood eosinophil count control condition (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77 days-91 days 8 0.08 x 1000 cells/ul 0.02 0.04 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41390 401
FHH-Chr 14BN/Mcwi blood eosinophil count control condition (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77 days-91 days 8 0.03 x 1000 cells/ul 0.01 0.04 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41406 401
FHH-Chr 14BN/Mcwi time to peak heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 6 1269.33 s 89.06 218.15 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46589 461
FHH-Chr 14BN/Mcwi heart rate air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 4 212.65 beats/min 17.6 35.21 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47613 461
FHH-Chr 14BN/Mcwi body weight control condition (for 21 days) PhysGen Vascular data body mass female 70 days-84 days 10 120.3 g 7.0 22.2 whole body digital scale 0 Moms and pups used in studies were fed Teklad 55396 522
FHH-Chr 14BN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 9 81.78 % 4.36 13.07 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54773 522
FHH-Chr 14BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 10 -7.99 null 0.13 0.41 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 56082 522
FHH-Chr 14BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 10 0.02 umol/l 0.0 0.01 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54667 522
FHH-Chr 14BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 8 20.09 ml/min/kg 2.06 5.83 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58609 526
FHH-Chr 14BN/Mcwi heart weight to body weight ratio control condition PhysGen Cardiac data heart mass female 49 days-63 days 9 5.48 g/kg 0.14 0.43 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 46968 461
FHH-Chr 14BN/Mcwi left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 7 39.04 mmHg 4.85 12.84 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47942 461
FHH-Chr 14BN/Mcwi heart contraction pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 6 23.23 mmHg 2.26 5.54 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48074 461
FHH-Chr 14BN/Mcwi body weight control condition PhysGen Cardiac data body mass female 49 days-63 days 9 125.1 g 7.8 23.4 whole body digital scale 0 Moms and pups used in studies were fed Teklad 47790 461
FHH-Chr 14BN/Mcwi percent change in tidal volume air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 104.43 % 4.94 15.62 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53927 381
FHH-Chr 14BN/Mcwi percent change in tidal volume air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 97.52 % 4.43 14.02 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54028 381
FHH-Chr 14BN/Mcwi serum alkaline phosphatase activity level control condition (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 8 356.38 U/l 22.19 62.77 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37452 401
FHH-Chr 14BN/Mcwi respiration rate air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 134.21 breaths/min 6.41 20.26 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14825 381
FHH-Chr 14BN/Mcwi respiration rate air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 10 149.55 breaths/min 3.37 10.66 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14836 381
FHH-Chr 14BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine albumin amount female 80 days-99 days 6 66.49 mg/d 34.22 83.82 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52394 482
FHH-Chr 14BN/Mcwi percent change in left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 7 post-ischemic value/pre-ischemic value x 100% 64.68 % 7.35 19.45 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46350 461
FHH-Chr 14BN/Mcwi left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 6 48.43 mmHg 8.41 20.6 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47952 461
FHH-Chr 14BN/Mcwi percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 6 post-ischemic value/pre-ischemic value x 100% 66.76 % 7.93 19.42 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46107 461
FHH-Chr 14BN/Mcwi tidal volume air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 0.34 ml 0.02 0.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16515 381
FHH-Chr 14BN/Mcwi FAPGG metabolism-surface area product FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 7 43.16 ml/min/kg 6.54 17.3 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58213 526
FHH-Chr 14BN/Mcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 26.01 ml/min 2.09 6.62 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16721 381
FHH-Chr 14BN/Mcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 26.66 ml/min 1.52 4.81 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16732 381
FHH-Chr 14BN/Mcwi left ventricular systolic blood pressure air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 4 66.14 mmHg 6.02 12.04 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49919 461
FHH-Chr 14BN/Mcwi serum total bilirubin level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 8 0.1 mg/dl 0.0 0.0 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41909 401
FHH-Chr 14BN/Mcwi mean corpuscular hemoglobin control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 8 17.81 pg 0.08 0.22 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40184 401
FHH-Chr 14BN/Mcwi serum globulin level control condition (for 14 days) PhysGen Biochemistry data blood globulin amount female 77 days-91 days 8 1.75 g/dl 0.05 0.14 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 41013 401
FHH-Chr 14BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 8 11.41 ml/min/kg 1.35 3.83 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 59980 526
FHH-Chr 14BN/Mcwi serum chloride level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 8 112.38 mmol/l 0.38 1.06 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39158 401