Phenominer Database Results (168 results)

 
 
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Strain Phenotype Conditions Study Experiment Name Sex Age # of Animals Formula Value Units SEM SD Method Method Duration Post Insult Time Value Clinical Measurement Notes Experiment Notes Record ID Study ID
FHH-Chr 13BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 0.21 ml 0.01 0.04 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13983 381
FHH-Chr 13BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 11 104.88 % 5.1 16.92 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53945 381
FHH-Chr 13BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 124.13 % 7.94 25.1 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53812 381
FHH-Chr 13BN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 9 0.04 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19798 381
FHH-Chr 13BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 10 74.9 mg/dl 1.16 3.67 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37157 401
FHH-Chr 13BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 10 58.79 fl 0.19 0.61 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38805 401
FHH-Chr 13BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount female 77 days-91 days 10 109.6 mmol/l 0.64 2.01 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39176 401
FHH-Chr 13BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 10 18.88 pg 0.06 0.18 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42605 401
FHH-Chr 13BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77 days-91 days 10 1.04 x 1000 cells/ul 0.12 0.37 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43284 401
FHH-Chr 13BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity female 77 days-91 days 10 0.1 x 1000 cells/ul 0.04 0.12 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39733 401
FHH-Chr 13BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 10 32.1 g/dl 0.11 0.34 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39837 401
FHH-Chr 13BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 10 63.8 U/l 3.52 11.12 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40774 401
FHH-Chr 13BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77 days-91 days 10 15.9 mmol/l 0.28 0.88 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38320 401
FHH-Chr 13BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 221.9 beats/min 10.39 32.86 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47641 461
FHH-Chr 13BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 8 51.53 mmHg 6.31 17.85 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46475 461
FHH-Chr 13BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 126.87 mmHg 4.66 13.97 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48683 461
FHH-Chr 13BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 18.19 ml/min/kg 0.94 2.99 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57657 526
FHH-Chr 13BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 25.71 ml/min/kg 1.56 4.94 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57859 526
FHH-Chr 13BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 0.45 null 0.03 0.1 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58172 526
FHH-Chr 13BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 7 2.15 mg/kg 0.8 2.12 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58965 526
FHH-Chr 13BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 8 6.38 ml/min/g 0.72 2.05 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44776 461
FHH-Chr 13BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 8 4.91 mmHg 0.41 1.15 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47255 461
FHH-Chr 13BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 8 272.88 beats/min 47.09 133.19 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45206 461
FHH-Chr 13BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount male 82 days-99 days 10 29.04 mmHg 1.19 3.75 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17254 381
FHH-Chr 13BN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 6 7.49 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17058 381
FHH-Chr 13BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 6 132.71 mmHg 5.85 14.32 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14340 381
FHH-Chr 13BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 9 182.74 beats/min 21.3 63.9 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45207 461
FHH-Chr 13BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 132.24 mmHg 4.63 13.88 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45788 461
FHH-Chr 13BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77 days-91 days 10 85.4 U/l 3.91 12.38 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42829 401
FHH-Chr 13BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 10 0.22 x 1000 cells/ul 0.08 0.25 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39734 401
FHH-Chr 13BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount female 77 days-91 days 10 134.3 mg/dl 3.55 11.23 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38589 401
FHH-Chr 13BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 9 0.43 IU/g 0.05 0.16 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47465 461
FHH-Chr 13BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77 days-91 days 10 21.1 mmol/l 0.74 2.33 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42121 401
FHH-Chr 13BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 0.15 mmHg x min x kg x ml-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59606 526
FHH-Chr 13BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 %change=VE during 2-3 min hypoxia/control during standard conditions 150.52 % 10.57 33.43 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13740 381
FHH-Chr 13BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77 days-91 days 10 309.5 U/l 11.95 37.78 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36438 401
FHH-Chr 13BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 11 138.39 breaths/min 5.0 16.58 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18326 381
FHH-Chr 13BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 10 5.3 g/dl 0.05 0.16 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37021 401
FHH-Chr 13BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 6 423.4 beats/min 19.24 47.14 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17513 381
FHH-Chr 13BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 9 396.11 beats/min 19.99 59.98 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17517 381
FHH-Chr 13BN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 6 -40.3 mmHg 3.63 8.9 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19473 381
FHH-Chr 13BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 9 962.22 s 62.3 186.9 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49357 461
FHH-Chr 13BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 10 -0.24 degrees C 0.13 0.41 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20369 381
FHH-Chr 13BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass male 49 days-63 days 10 170.6 g 6.2 19.5 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49544 461
FHH-Chr 13BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 10 94.9 U/l 5.39 17.04 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42830 401
FHH-Chr 13BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 10 8.21 x 10E6 cells/ul 0.08 0.26 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39296 401
FHH-Chr 13BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount female 77 days-91 days 10 142.5 mmol/l 0.65 2.07 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39447 401
FHH-Chr 13BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77 days-91 days 10 0.25 mg/dl 0.02 0.05 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39635 401
FHH-Chr 13BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 10 2.54 mg/kg 0.52 1.65 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58966 526
FHH-Chr 13BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass male 77 days-91 days 10 187.0 g 6.3 19.9 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59122 526
FHH-Chr 13BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77 days-91 days 10 54.41 % 0.5 1.59 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59317 526
FHH-Chr 13BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77 days-91 days 10 4.88 x 1000 cells/ul 0.28 0.89 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40985 401
FHH-Chr 13BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 10 6.27 x 1000 cells/ul 0.49 1.56 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40986 401
FHH-Chr 13BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount female 77 days-91 days 10 1.33 g/dl 0.04 0.12 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40609 401
FHH-Chr 13BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77 days-91 days 10 0.04 x 1000 cells/ul 0.02 0.05 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41707 401
FHH-Chr 13BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount male 77 days-91 days 10 142.4 mg/dl 3.9 12.34 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38590 401
FHH-Chr 13BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 11 36.89 degrees C 0.14 0.47 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16633 381
FHH-Chr 13BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 10 0.39 null 0.02 0.05 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58173 526
FHH-Chr 13BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 10 0.04 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58549 526
FHH-Chr 13BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass female 77 days-91 days 10 0.43 null 0.03 0.1 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58792 526
FHH-Chr 13BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 5 137.08 mmHg 8.45 18.89 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45787 461
FHH-Chr 13BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 9 12.53 ml/min/g 0.5 1.49 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46711 461
FHH-Chr 13BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 9 7.19 g/kg 0.27 0.8 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45638 461
FHH-Chr 13BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 11 0.31 degrees C 0.2 0.66 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20370 381
FHH-Chr 13BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 131.83 breaths/min 10.04 31.74 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18325 381
FHH-Chr 13BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 11 %change=VE during 2-3 min hypoxia/control during standard conditions 136.09 % 10.41 34.53 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13741 381
FHH-Chr 13BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 80.81 % 8.49 25.47 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48354 461
FHH-Chr 13BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 5.26 mmHg 0.26 0.81 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47256 461
FHH-Chr 13BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 11.57 ml/min/g 0.53 1.66 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46712 461
FHH-Chr 13BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77 days-91 days 10 4.06 x 1000 cells/ul 0.22 0.71 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41562 401
FHH-Chr 13BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 10 961.6 s 36.28 114.72 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49358 461
FHH-Chr 13BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 54.59 mmHg 1.51 4.78 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46476 461
FHH-Chr 13BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 8 9.82 % 3.38 9.56 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49756 461
FHH-Chr 13BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77 days-91 days 10 0.04 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58548 526
FHH-Chr 13BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 40.3 % 4.31 12.92 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48586 461
FHH-Chr 13BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 10 4.05 g/dl 0.03 0.1 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42293 401
FHH-Chr 13BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass male 77 days-91 days 10 1.47 g/kg 0.03 0.09 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59717 526
FHH-Chr 13BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 10 22.77 ml/min/kg 1.69 5.35 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57860 526
FHH-Chr 13BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 11 0.25 ml 0.02 0.05 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15294 381
FHH-Chr 13BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 28.48 ml/min 3.06 9.66 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18722 381
FHH-Chr 13BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 122.6 breaths/min 6.9 21.82 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14854 381
FHH-Chr 13BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 11 127.33 breaths/min 3.37 11.19 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14855 381
FHH-Chr 13BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 9 126.14 mmHg 3.59 10.78 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14344 381
FHH-Chr 13BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 10 9.92 mg/dl 0.13 0.4 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36684 401
FHH-Chr 13BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 9 1176.11 s 57.19 171.56 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50285 461
FHH-Chr 13BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount female 77 days-91 days 10 3.97 g/dl 0.04 0.12 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42292 401
FHH-Chr 13BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 10 20.5 mmol/l 0.54 1.72 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42122 401
FHH-Chr 13BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 10 19.35 pg 0.07 0.22 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42604 401
FHH-Chr 13BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 10 9.26 x 10E6 cells/ul 0.1 0.3 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39297 401
FHH-Chr 13BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 131.97 % 8.33 26.34 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54385 381
FHH-Chr 13BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77 days-91 days 10 51.5 U/l 3.93 12.44 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40773 401
FHH-Chr 13BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity female 77 days-91 days 10 49.64 % 0.5 1.58 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59316 526
FHH-Chr 13BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 10 1.48 g/dl 0.04 0.13 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40610 401
FHH-Chr 13BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 10 7.93 mg/dl 0.13 0.42 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37654 401
FHH-Chr 13BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 10 0.1 mg/dl 0.0 0.0 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41928 401
FHH-Chr 13BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 10 14.92 ml/min/kg 0.86 2.72 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57658 526
FHH-Chr 13BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 8 26.68 IU/g 3.46 9.8 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45981 461
FHH-Chr 13BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 51.0 % 4.82 13.63 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47135 461
FHH-Chr 13BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 48.17 mmHg 5.56 17.6 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45329 461
FHH-Chr 13BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 10 52.2 mmHg 1.9 6.01 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20489 381
FHH-Chr 13BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77 days-91 days 10 65.7 mg/dl 1.52 4.81 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37156 401
FHH-Chr 13BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 8 45.0 mmHg 9.34 26.41 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45328 461
FHH-Chr 13BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77 days-91 days 10 60.43 fl 0.22 0.71 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38804 401
FHH-Chr 13BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77 days-91 days 10 19.6 mg/dl 1.06 3.34 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40887 401
FHH-Chr 13BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 11 103.66 % 5.36 17.78 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54046 381
FHH-Chr 13BN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 9 7.5 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17062 381
FHH-Chr 13BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 116.74 % 5.93 18.75 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53944 381
FHH-Chr 13BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 10 5.53 g/dl 0.04 0.14 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37022 401
FHH-Chr 13BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 11 31.58 ml/min 2.72 9.03 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20269 381
FHH-Chr 13BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 102.76 mmHg 5.63 17.79 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49947 461
FHH-Chr 13BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 9 42.78 mmHg 5.96 17.89 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50055 461
FHH-Chr 13BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 10 108.9 mmol/l 0.48 1.52 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39177 401
FHH-Chr 13BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 10 32.0 g/dl 0.11 0.33 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39836 401
FHH-Chr 13BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77 days-91 days 10 8.13 mg/dl 0.35 1.1 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37653 401
FHH-Chr 13BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass female 77 days-91 days 10 1.61 g/kg 0.03 0.09 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59716 526
FHH-Chr 13BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 10 0.15 mmHg x min x kg x ml-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59607 526
FHH-Chr 13BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 10 18.3 mmol/l 0.26 0.82 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38321 401
FHH-Chr 13BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 9 1.04 g 0.04 0.11 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45463 461
FHH-Chr 13BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 10 1.11 g 0.02 0.07 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45464 461
FHH-Chr 13BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77 days-91 days 10 0.1 mg/dl 0.01 0.02 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41927 401
FHH-Chr 13BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 60.03 ml/min/kg 4.64 14.68 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58058 526
FHH-Chr 13BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 10 59.29 ml/min/kg 4.9 15.49 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58059 526
FHH-Chr 13BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass male 77 days-91 days 10 0.4 null 0.03 0.1 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58793 526
FHH-Chr 13BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 10 6.56 g/kg 0.24 0.75 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45642 461
FHH-Chr 13BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 24.11 ml/min 2.86 9.04 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20268 381
FHH-Chr 13BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 105.85 % 7.44 23.54 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54045 381
FHH-Chr 13BN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 6 -7.93 mmHg 1.81 4.44 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19642 381
FHH-Chr 13BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount female 77 days-91 days 10 9.69 mg/dl 0.14 0.43 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36683 401
FHH-Chr 13BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass female 49 days-63 days 10 147.1 g 5.4 17.1 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49540 461
FHH-Chr 13BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77 days-91 days 10 0.09 x 1000 cells/ul 0.02 0.08 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41706 401
FHH-Chr 13BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77 days-91 days 10 0.61 x 1000 cells/ul 0.07 0.21 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43283 401
FHH-Chr 13BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 8 96.53 mmHg 6.97 19.7 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49946 461
FHH-Chr 13BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass female 77 days-91 days 10 161.6 g 2.6 8.3 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59121 526
FHH-Chr 13BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 10 0.44 IU/g 0.06 0.2 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47469 461
FHH-Chr 13BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 10 41.1 mmHg 1.97 6.23 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50056 461
FHH-Chr 13BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 5 132.75 mmHg 8.61 19.25 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48682 461
FHH-Chr 13BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 4 post-ischemic value/pre-ischemic value x 100% 75.9 % 6.04 12.07 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48814 461
FHH-Chr 13BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 11 0.25 ml 0.01 0.05 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13984 381
FHH-Chr 13BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount female 82 days-99 days 6 28.78 mmHg 1.56 3.83 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17250 381
FHH-Chr 13BN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 6 0.06 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19795 381
FHH-Chr 13BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 11 119.25 % 5.26 17.46 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53813 381
FHH-Chr 13BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 10 422.5 U/l 13.35 42.23 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36439 401
FHH-Chr 13BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 0.19 ml 0.01 0.05 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15293 381
FHH-Chr 13BN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 10 -5.91 mmHg 1.3 4.1 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19646 381
FHH-Chr 13BN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 10 -39.21 mmHg 2.0 6.31 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19477 381
FHH-Chr 13BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 6 53.02 mmHg 2.01 4.92 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20485 381
FHH-Chr 13BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 10 6.43 % 2.58 8.15 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49757 461
FHH-Chr 13BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 10 54.41 % 0.5 1.59 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39051 401
FHH-Chr 13BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 10 142.8 mmol/l 0.63 1.99 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39448 401
FHH-Chr 13BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 10 0.31 mg/dl 0.02 0.06 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39636 401
FHH-Chr 13BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77 days-91 days 10 20.2 mg/dl 1.12 3.55 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40888 401
FHH-Chr 13BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 10 15.87 g/dl 0.16 0.49 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38027 401
FHH-Chr 13BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 10 17.48 g/dl 0.16 0.5 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38028 401
FHH-Chr 13BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount female 77 days-91 days 10 4.13 mmol/l 0.11 0.36 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38125 401
FHH-Chr 13BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 10 4.68 mmol/l 0.2 0.63 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38126 401
FHH-Chr 13BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 10 4.91 x 1000 cells/ul 0.44 1.39 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41563 401
FHH-Chr 13BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 4 post-ischemic value/pre-ischemic value x 100% 38.04 % 14.32 28.64 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48585 461
FHH-Chr 13BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 80.48 % 4.59 13.76 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48815 461
FHH-Chr 13BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 10 36.91 degrees C 0.14 0.43 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16632 381
FHH-Chr 13BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 10 27.79 IU/g 2.7 8.54 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45985 461
FHH-Chr 13BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 109.91 % 16.79 47.48 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48353 461
FHH-Chr 13BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 11 34.52 ml/min 2.7 8.95 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18723 381
FHH-Chr 13BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 39.88 % 2.24 7.09 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47136 461
FHH-Chr 13BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 4.62 ml/min/g 0.33 1.04 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44777 461
FHH-Chr 13BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 11 129.64 % 6.46 21.43 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54386 381
FHH-Chr 13BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 1157.5 s 35.08 110.95 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50286 461
FHH-Chr 13BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 9 245.92 beats/min 10.87 32.62 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47640 461
FHH-Chr 13BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 10 49.64 % 0.5 1.58 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39050 401