Phenominer Database Results (429 results)

 

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Strain Phenotype Conditions Study Experiment Name Sex Age # of Animals Formula Value Units SEM SD Method Method Duration Post Insult Time Value Method Notes Clinical Measurement Notes Experiment Notes Record ID Study ID
FHH-Chr 12BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount male 80 days-99 days 10 0.37 mg/dl 0.03 0.08 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52262 482
FHH-Chr 12BN/Mcwi heart rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data heart pumping trait female 80 days-99 days 11 435.43 beats/min 9.42 31.23 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52484 482
FHH-Chr 12BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 19 %change=VE during 2-3 min hypoxia/control during standard conditions 134.35 % 5.92 25.78 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13665 381
FHH-Chr 12BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 17 122.37 mmHg 3.52 14.5 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14302 381
FHH-Chr 12BN/Mcwi minute ventilation controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 51.95 ml/min 2.61 8.25 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20752 381
FHH-Chr 12BN/Mcwi serum total protein level control condition (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 11 5.76 g/dl 0.1 0.34 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37181 401
FHH-Chr 12BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 11 5.87 g/dl 0.06 0.2 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36953 401
FHH-Chr 12BN/Mcwi minute ventilation controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 17 58.76 ml/min 2.91 11.98 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14485 381
FHH-Chr 12BN/Mcwi percent change in respiration rate controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 17 154.72 % 4.39 18.1 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54202 381
FHH-Chr 12BN/Mcwi percent change in respiration rate controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 10 138.51 % 4.58 14.49 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54208 381
FHH-Chr 12BN/Mcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 11 0.25 ml 0.02 0.05 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 17973 381
FHH-Chr 12BN/Mcwi blood pH control condition PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 13 7.42 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20596 381
FHH-Chr 12BN/Mcwi blood pH control condition PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 11 7.45 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20607 381
FHH-Chr 12BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 11 9.71 mg/dl 0.1 0.34 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36615 401
FHH-Chr 12BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 11 411.34 beats/min 11.45 37.98 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17487 381
FHH-Chr 12BN/Mcwi serum sodium level control condition (for 14 days) PhysGen Biochemistry data blood sodium amount female 77 days-91 days 11 144.91 mmol/l 0.74 2.47 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36473 401
FHH-Chr 12BN/Mcwi serum sodium level control condition (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 12 144.25 mmol/l 0.85 2.96 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36489 401
FHH-Chr 12BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 19 26.0 ml/min 0.89 3.89 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20193 381
FHH-Chr 12BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 19 -0.29 degrees C 0.12 0.54 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20294 381
FHH-Chr 12BN/Mcwi time to onset of heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 22 966.95 s 32.86 154.13 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50104 461
FHH-Chr 12BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass male 49 days-63 days 12 169.2 g 6.0 20.7 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49508 461
FHH-Chr 12BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77 days-91 days 12 15.17 mmol/l 0.89 3.1 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42047 401
FHH-Chr 12BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 11 13.64 mmol/l 0.51 1.69 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42053 401
FHH-Chr 12BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 11 9.93 x 10E6 cells/ul 0.12 0.4 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39228 401
FHH-Chr 12BN/Mcwi percent change in respiration rate controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 10 143.04 % 5.46 17.27 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53623 381
FHH-Chr 12BN/Mcwi blood monocyte count control condition (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 12 0.29 x 1000 cells/ul 0.05 0.19 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40293 401
FHH-Chr 12BN/Mcwi serum chloride level control condition (for 14 days) PhysGen Biochemistry data blood chloride amount female 77 days-91 days 11 106.91 mmol/l 0.67 2.21 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39989 401
FHH-Chr 12BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77 days-91 days 11 0.05 mmHg-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59341 526
FHH-Chr 12BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount female 77 days-91 days 12 2.02 g/dl 0.03 0.1 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40535 401
FHH-Chr 12BN/Mcwi serum globulin level control condition (for 14 days) PhysGen Biochemistry data blood globulin amount female 77 days-91 days 11 2.05 g/dl 0.05 0.16 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 41010 401
FHH-Chr 12BN/Mcwi serum chloride level control condition (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 12 104.67 mmol/l 0.7 2.42 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40005 401
FHH-Chr 12BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77 days-91 days 12 4.89 x 1000 cells/ul 0.44 1.53 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40911 401
FHH-Chr 12BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 12 16.41 g/dl 0.18 0.64 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 37953 401
FHH-Chr 12BN/Mcwi serum urea nitrogen level control condition (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77 days-91 days 11 14.0 mg/dl 1.11 3.69 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41735 401
FHH-Chr 12BN/Mcwi time to peak heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 21 1211.05 s 31.11 142.56 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46539 461
FHH-Chr 12BN/Mcwi red blood cell count control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 12 8.36 x 10E6 cells/ul 0.21 0.72 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41968 401
FHH-Chr 12BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 11 0.1 mg/dl 0.0 0.0 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41859 401
FHH-Chr 12BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 12 16.94 ml/min/kg 0.59 2.05 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57583 526
FHH-Chr 12BN/Mcwi maximum contractile force per wet weight of aorta potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 12 1.5 g/mg 0.12 0.42 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55762 522
FHH-Chr 12BN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 11 -6.77 null 0.11 0.38 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55599 522
FHH-Chr 12BN/Mcwi heart right ventricle weight to left ventricle weight ratio control condition (for 14 days) PhysGen Lung data heart right ventricle mass male 77 days-91 days 12 0.24 null 0.01 0.02 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 57900 526
FHH-Chr 12BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 10 43.78 ml/min/kg 3.48 10.99 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57990 526
FHH-Chr 12BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 11 36.43 degrees C 0.21 0.68 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16563 381
FHH-Chr 12BN/Mcwi body temperature control condition PhysGen Respiratory data body temperature trait male 82 days-99 days 11 36.76 degrees C 0.27 0.9 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16803 381
FHH-Chr 12BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 11 0.75 E-7mole 0.08 0.27 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55884 522
FHH-Chr 12BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77 days-91 days 12 0.04 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58474 526
FHH-Chr 12BN/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 7 18.0 % 3.53 9.33 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56281 522
FHH-Chr 12BN/Mcwi sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 3 93.67 % 6.33 10.97 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56302 522
FHH-Chr 12BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 11 0.02 umol/l 0.0 0.01 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54664 522
FHH-Chr 12BN/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 7 10.29 % 1.87 4.96 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55081 522
FHH-Chr 12BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 22.9 ml/min/kg 1.5 4.75 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58606 526
FHH-Chr 12BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass male 77 days-91 days 11 0.52 null 0.02 0.08 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58724 526
FHH-Chr 12BN/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 10 14.7 % 3.41 10.78 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55141 522
FHH-Chr 12BN/Mcwi partial pressure of blood carbon dioxide (Pco2) control condition PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 11 34.27 mmHg 1.2 3.97 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 16053 381
FHH-Chr 12BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 5 20.8 IU/g 5.77 12.9 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45949 461
FHH-Chr 12BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 4.36 ml/min/g 0.47 1.49 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44709 461
FHH-Chr 12BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 12 7.27 g/kg 0.45 1.57 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45606 461
FHH-Chr 12BN/Mcwi percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 22 post-ischemic value/pre-ischemic value x 100% 65.22 % 4.3 20.15 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46051 461
FHH-Chr 12BN/Mcwi percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 20 post-ischemic value/pre-ischemic value x 100% 66.78 % 5.28 23.63 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46057 461
FHH-Chr 12BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 11 115.85 % 6.55 21.74 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53742 381
FHH-Chr 12BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 11 56.49 mmHg 1.9 6.3 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20459 381
FHH-Chr 12BN/Mcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 0.26 ml 0.02 0.05 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15388 381
FHH-Chr 12BN/Mcwi mean arterial blood pressure controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data arterial blood pressure trait male 80 days-99 days 12 189.93 mmHg 4.66 16.14 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52550 482
FHH-Chr 12BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 14 52.44 mmHg 3.49 13.04 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46402 461
FHH-Chr 12BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 47.22 mmHg 8.01 25.34 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45261 461
FHH-Chr 12BN/Mcwi left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 19 99.67 mmHg 3.55 15.47 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 44806 461
FHH-Chr 12BN/Mcwi FAPGG metabolism-surface area product FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 11 67.87 ml/min/kg 3.78 12.53 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58210 526
FHH-Chr 12BN/Mcwi body weight control condition (for 14 days) PhysGen Lung data body mass female 77 days-91 days 12 163.8 g 3.5 12.3 whole body digital scale 0 Moms and pups used in studies were fed Teklad 58321 526
FHH-Chr 12BN/Mcwi percent change in tidal volume controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 17 149.26 % 4.9 20.18 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54408 381
FHH-Chr 12BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77 days-91 days 12 0.04 x 1000 cells/ul 0.01 0.05 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41632 401
FHH-Chr 12BN/Mcwi logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 3 -8.38 null 0.31 0.54 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56015 522
FHH-Chr 12BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 16 38.56 mmHg 2.77 11.09 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49982 461
FHH-Chr 12BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77 days-91 days 12 41.75 U/l 2.01 6.97 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40699 401
FHH-Chr 12BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 5 post-ischemic value/pre-ischemic value x 100% 43.85 % 11.32 25.31 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48512 461
FHH-Chr 12BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 140.05 mmHg 11.43 32.33 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48615 461
FHH-Chr 12BN/Mcwi sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 3 100.0 % 0.0 0.0 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56462 522
FHH-Chr 12BN/Mcwi blood eosinophil count control condition (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77 days-91 days 12 0.02 x 1000 cells/ul 0.01 0.03 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41403 401
FHH-Chr 12BN/Mcwi heart rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data heart pumping trait male 80 days-99 days 12 431.99 beats/min 6.5 22.51 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52503 482
FHH-Chr 12BN/Mcwi urine total protein excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data total urine protein amount male 80 days-99 days 11 368.02 mg/d 45.8 151.92 automated urine total protein analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52113 482
FHH-Chr 12BN/Mcwi urine sodium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine sodium amount male 80 days-99 days 11 14.16 mEq/d 1.75 5.8 flame atomic emission spectrometry 0 Moms were fed Teklad, pups used in studies were fed Dyets 52799 482
FHH-Chr 12BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 19 0.24 ml 0.01 0.04 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13908 381
FHH-Chr 12BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 11 %change=VE during 2-3 min hypoxia/control during standard conditions 121.4 % 7.59 25.19 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13671 381
FHH-Chr 12BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 11 107.2 % 7.1 23.56 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53874 381
FHH-Chr 12BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 19 97.92 % 3.21 13.97 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53969 381
FHH-Chr 12BN/Mcwi heart rate control condition PhysGen Respiratory data heart pumping trait female 82 days-99 days 17 407.29 beats/min 10.17 41.93 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 20893 381
FHH-Chr 12BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77 days-91 days 12 286.33 U/l 7.3 25.29 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36364 401
FHH-Chr 12BN/Mcwi respiration rate control condition PhysGen Respiratory data respiratory function trait male 82 days-99 days 11 113.93 breaths/min 4.62 15.33 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18401 381
FHH-Chr 12BN/Mcwi partial pressure of blood oxygen control condition PhysGen Respiratory data blood oxygen amount female 82 days-99 days 13 103.25 mmHg 2.21 7.95 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 18840 381
FHH-Chr 12BN/Mcwi heart rate control condition PhysGen Respiratory data heart pumping trait female 82 days-99 days 15 421.37 beats/min 8.75 33.89 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 15902 381
FHH-Chr 12BN/Mcwi heart rate control condition PhysGen Respiratory data heart pumping trait male 82 days-99 days 10 400.83 beats/min 14.89 47.09 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 15912 381
FHH-Chr 12BN/Mcwi absolute change in body temperature controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 10 -0.05 degrees C 0.31 1.0 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 15660 381
FHH-Chr 12BN/Mcwi body weight control condition PhysGen Respiratory data body mass male 82 days-99 days 11 249.4 g 3.5 11.5 whole body digital scale 0 Moms and pups used in studies were fed Dyets 17808 381
FHH-Chr 12BN/Mcwi blood lymphocyte count control condition (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 12 3.47 x 1000 cells/ul 0.35 1.22 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 36868 401
FHH-Chr 12BN/Mcwi heart wet weight control condition PhysGen Cardiac data heart mass male 49 days-63 days 22 0.9 g 0.04 0.18 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49051 461
FHH-Chr 12BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 17 411.57 beats/min 13.0 53.6 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17475 381
FHH-Chr 12BN/Mcwi left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 21 5.73 mmHg 0.16 0.73 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49168 461
FHH-Chr 12BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 15 891.13 s 79.07 306.24 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49284 461
FHH-Chr 12BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 12 909.5 s 58.4 202.32 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49290 461
FHH-Chr 12BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount female 77 days-91 days 12 3.91 g/dl 0.03 0.11 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42218 401
FHH-Chr 12BN/Mcwi total white blood cell count control condition (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 12 4.74 x 1000 cells/ul 0.44 1.52 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39884 401
FHH-Chr 12BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 19 127.71 % 3.97 17.31 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54309 381
FHH-Chr 12BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity female 77 days-91 days 12 0.11 x 1000 cells/ul 0.02 0.06 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39659 401
FHH-Chr 12BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 11 0.22 x 1000 cells/ul 0.04 0.15 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39665 401
FHH-Chr 12BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 12 32.12 g/dl 0.1 0.36 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39762 401
FHH-Chr 12BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 11 32.27 g/dl 0.07 0.24 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39768 401
FHH-Chr 12BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass female 77 days-91 days 12 157.8 g 3.4 11.7 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59047 526
FHH-Chr 12BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 10 2.1 mg/kg 0.49 1.55 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59148 526
FHH-Chr 12BN/Mcwi blood hemoglobin level control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 11 13.67 g/dl 0.29 0.95 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40085 401
FHH-Chr 12BN/Mcwi blood hemoglobin level control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 12 14.02 g/dl 0.34 1.18 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40101 401
FHH-Chr 12BN/Mcwi serum albumin level control condition (for 14 days) PhysGen Biochemistry data blood albumin amount female 77 days-91 days 11 3.71 g/dl 0.07 0.23 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40390 401
FHH-Chr 12BN/Mcwi plasma anion gap control condition (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 11 23.27 mmol/l 0.68 2.24 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 43130 401
FHH-Chr 12BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 12 0.06 mmHg-1 0.01 0.03 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59357 526
FHH-Chr 12BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass male 77 days-91 days 12 1.53 g/kg 0.02 0.07 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59648 526
FHH-Chr 12BN/Mcwi serum glucose level control condition (for 14 days) PhysGen Biochemistry data blood glucose amount male 77 days-91 days 11 155.27 mg/dl 2.5 8.28 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41193 401
FHH-Chr 12BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 9 0.4 null 0.02 0.07 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 59772 526
FHH-Chr 12BN/Mcwi serum alanine aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 12 70.17 U/l 3.35 11.61 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37706 401
FHH-Chr 12BN/Mcwi serum phosphate level control condition (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77 days-91 days 11 7.67 mg/dl 0.35 1.17 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37810 401
FHH-Chr 12BN/Mcwi serum total cholesterol level control condition (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 12 100.08 mg/dl 3.64 12.62 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38432 401
FHH-Chr 12BN/Mcwi serum urea nitrogen level control condition (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77 days-91 days 12 15.17 mg/dl 1.02 3.54 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41751 401
FHH-Chr 12BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 11 -7.73 null 0.07 0.23 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 55265 522
FHH-Chr 12BN/Mcwi body weight control condition (for 21 days) PhysGen Vascular data body mass female 70 days-84 days 21 179.4 g 2.8 12.9 whole body digital scale 0 Moms and pups used in studies were fed Teklad 55393 522
FHH-Chr 12BN/Mcwi FAPGG metabolism-surface area product FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 10 51.47 ml/min/kg 2.39 7.54 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58226 526
FHH-Chr 12BN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 12 70.75 % 7.19 24.91 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54754 522
FHH-Chr 12BN/Mcwi calculated pulmonary vascular resistance normalized to body weight Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 12 0.12 mmHg x min x kg x ml-1 0.0 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59887 526
FHH-Chr 12BN/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 3 13.33 % 7.97 13.8 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55070 522
FHH-Chr 12BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 16 1.46 E-7mole 0.27 1.09 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56510 522
FHH-Chr 12BN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 12 -6.85 null 0.07 0.23 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56889 522
FHH-Chr 12BN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 16 -6.99 null 0.11 0.44 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56905 522
FHH-Chr 12BN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 11 71.18 % 5.54 18.37 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57198 522
FHH-Chr 12BN/Mcwi partial pressure of blood carbon dioxide (Pco2) control condition PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 13 37.04 mmHg 0.85 3.07 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 16042 381
FHH-Chr 12BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 14 5.93 ml/min/g 0.73 2.74 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44703 461
FHH-Chr 12BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 11 121.86 mmHg 4.68 15.53 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45714 461
FHH-Chr 12BN/Mcwi heart weight to body weight ratio control condition PhysGen Cardiac data heart mass female 49 days-63 days 21 5.31 g/kg 0.17 0.79 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 46965 461
FHH-Chr 12BN/Mcwi heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 21 245.76 beats/min 6.15 28.17 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48188 461
FHH-Chr 12BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 259.58 beats/min 49.97 158.03 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45139 461
FHH-Chr 12BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 5.91 mmHg 0.14 0.41 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47182 461
FHH-Chr 12BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 12 0.34 IU/g 0.03 0.1 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47438 461
FHH-Chr 12BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77 days-91 days 12 75.25 mg/dl 1.64 5.69 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37082 401
FHH-Chr 12BN/Mcwi respiration rate controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 10 153.76 breaths/min 7.87 24.89 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16902 381
FHH-Chr 12BN/Mcwi body temperature controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 10 36.64 degrees C 0.15 0.47 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 13550 381
FHH-Chr 12BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine albumin amount male 80 days-99 days 11 111.94 mg/d 15.39 51.03 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52405 482
FHH-Chr 12BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 16 post-ischemic value/pre-ischemic value x 100% 43.75 % 6.29 25.15 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47062 461
FHH-Chr 12BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 12 post-ischemic value/pre-ischemic value x 100% 30.85 % 5.02 17.38 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47068 461
FHH-Chr 12BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 13 207.48 beats/min 12.18 43.92 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45133 461
FHH-Chr 12BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 16 0.29 IU/g 0.06 0.24 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47422 461
FHH-Chr 12BN/Mcwi left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 22 46.95 mmHg 3.14 14.71 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47686 461
FHH-Chr 12BN/Mcwi heart weight to body weight ratio control condition PhysGen Cardiac data heart mass male 49 days-63 days 22 5.6 g/kg 0.27 1.26 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 46981 461
FHH-Chr 12BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77 days-91 days 11 0.05 x 1000 cells/ul 0.02 0.06 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41638 401
FHH-Chr 12BN/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 3 38.67 % 4.33 7.51 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57165 522
FHH-Chr 12BN/Mcwi serum bicarbonate level control condition (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77 days-91 days 11 19.45 mmol/l 0.59 1.97 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42973 401
FHH-Chr 12BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 12 0.04 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58480 526
FHH-Chr 12BN/Mcwi percent change in ventilation controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 %change=VE during 2-3 min hypercapnia/control during standard conditions 222.25 % 17.11 54.1 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 19202 381
FHH-Chr 12BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass male 77 days-91 days 12 193.3 g 3.2 11.1 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59053 526
FHH-Chr 12BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 11 53.82 U/l 2.48 8.22 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40705 401
FHH-Chr 12BN/Mcwi lung dry weight to body weight ratio control condition (for 14 days) PhysGen Lung data lung mass female 77 days-91 days 12 1.13 g/kg 0.02 0.07 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59437 526
FHH-Chr 12BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 11 -8.09 null 0.08 0.28 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 55249 522
FHH-Chr 12BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 12 8.97 x 10E6 cells/ul 0.1 0.33 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39222 401
FHH-Chr 12BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 11 14.25 ml/min/kg 0.62 2.05 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 59993 526
FHH-Chr 12BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount female 77 days-91 days 12 4.37 mmol/l 0.16 0.56 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38051 401
FHH-Chr 12BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 11 143.09 mmol/l 0.34 1.14 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39379 401
FHH-Chr 12BN/Mcwi urine total protein excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data total urine protein amount female 80 days-99 days 10 157.28 mg/d 60.1 190.06 automated urine total protein analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52094 482
FHH-Chr 12BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data renin activity male 80 days-99 days 10 1.71 ng/ml/h 0.17 0.52 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52897 482
FHH-Chr 12BN/Mcwi urine potassium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine potassium amount female 80 days-99 days 10 0.9 mEq/d 0.07 0.21 flame atomic emission spectrometry 0 urine potassium analysis Moms were fed Teklad, pups used in studies were fed Dyets 52292 482
FHH-Chr 12BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 11 129.58 breaths/min 4.82 15.97 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14785 381
FHH-Chr 12BN/Mcwi percent change in ventilation controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 17 %change=VE during7-9 min hypercapnia/control during standard conditions 231.99 % 10.97 45.25 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14183 381
FHH-Chr 12BN/Mcwi body temperature controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 17 36.87 degrees C 0.1 0.42 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 13544 381
FHH-Chr 12BN/Mcwi mean arterial blood pressure controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 15 113.14 mmHg 3.66 14.18 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 13459 381
FHH-Chr 12BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 19 0.23 ml 0.01 0.04 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15218 381
FHH-Chr 12BN/Mcwi respiration rate control condition PhysGen Respiratory data respiratory function trait female 82 days-99 days 17 91.43 breaths/min 2.24 9.22 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14920 381
FHH-Chr 12BN/Mcwi respiration rate control condition PhysGen Respiratory data respiratory function trait male 82 days-99 days 10 107.63 breaths/min 4.0 12.65 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14926 381
FHH-Chr 12BN/Mcwi percent change in tidal volume controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 153.98 % 7.8 24.66 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54074 381
FHH-Chr 12BN/Mcwi respiration rate controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 17 140.16 breaths/min 2.16 8.91 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 17096 381
FHH-Chr 12BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 11 0.26 ml 0.01 0.05 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13914 381
FHH-Chr 12BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 19 105.47 % 3.84 16.75 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53868 381
FHH-Chr 12BN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 11 7.49 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17032 381
FHH-Chr 12BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 11 81.45 mg/dl 2.51 8.31 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37088 401
FHH-Chr 12BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 11 33.51 ml/min 1.39 4.6 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18653 381
FHH-Chr 12BN/Mcwi mean corpuscular hemoglobin concentration control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 11 32.23 g/dl 0.31 1.02 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 37311 401
FHH-Chr 12BN/Mcwi body temperature control condition PhysGen Respiratory data body temperature trait male 82 days-99 days 10 36.69 degrees C 0.26 0.82 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 19060 381
FHH-Chr 12BN/Mcwi percent change in ventilation controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 11 %change=VE during7-9 min hypercapnia/control during standard conditions 120.06 % 12.4 41.13 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18534 381
FHH-Chr 12BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 11 129.06 breaths/min 5.06 16.79 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18256 381
FHH-Chr 12BN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 12 -46.38 mmHg 1.86 6.45 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19436 381
FHH-Chr 12BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 16 1196.63 s 65.49 261.97 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50212 461
FHH-Chr 12BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 11 8.86 % 3.33 11.03 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49689 461
FHH-Chr 12BN/Mcwi serum aspartate aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77 days-91 days 11 84.27 U/l 4.77 15.81 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42400 401
FHH-Chr 12BN/Mcwi serum aspartate aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 12 103.25 U/l 5.3 18.36 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42416 401
FHH-Chr 12BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 12 18.31 pg 0.06 0.21 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42530 401
FHH-Chr 12BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 11 17.95 pg 0.07 0.24 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42536 401
FHH-Chr 12BN/Mcwi plasma creatinine level control condition (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 12 0.18 mg/dl 0.03 0.09 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 42645 401
FHH-Chr 12BN/Mcwi plasma anion gap control condition (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77 days-91 days 11 22.73 mmol/l 0.63 2.1 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 43114 401
FHH-Chr 12BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 19 129.03 % 6.28 27.38 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53736 381
FHH-Chr 12BN/Mcwi serum albumin level control condition (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 12 3.59 g/dl 0.08 0.28 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40406 401
FHH-Chr 12BN/Mcwi serum potassium level control condition (for 14 days) PhysGen Biochemistry data blood potassium amount female 77 days-91 days 11 4.18 mmol/l 0.13 0.43 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 43310 401
FHH-Chr 12BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 11 8.2 mg/dl 0.18 0.59 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37585 401
FHH-Chr 12BN/Mcwi serum glucose level control condition (for 14 days) PhysGen Biochemistry data blood glucose amount female 77 days-91 days 11 164.09 mg/dl 9.56 31.7 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41177 401
FHH-Chr 12BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 0.34 null 0.01 0.04 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 59756 526
FHH-Chr 12BN/Mcwi serum phosphate level control condition (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 11 8.04 mg/dl 0.22 0.71 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37826 401
FHH-Chr 12BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 12 0.19 mmHg x min x kg x ml-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59538 526
FHH-Chr 12BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 11 5.26 mmol/l 0.16 0.52 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38057 401
FHH-Chr 12BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77 days-91 days 12 4.08 x 1000 cells/ul 0.43 1.5 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41488 401
FHH-Chr 12BN/Mcwi time to peak heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 22 1144.4 s 60.82 285.28 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46533 461
FHH-Chr 12BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 32.38 % 5.22 14.77 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48518 461
FHH-Chr 12BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77 days-91 days 12 0.12 mg/dl 0.01 0.04 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41853 401
FHH-Chr 12BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 12 post-ischemic value/pre-ischemic value x 100% 82.98 % 8.82 30.56 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48741 461
FHH-Chr 12BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 11 post-ischemic value/pre-ischemic value x 100% 73.96 % 7.93 26.31 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48747 461
FHH-Chr 12BN/Mcwi heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 17 213.78 beats/min 8.8 36.3 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48936 461
FHH-Chr 12BN/Mcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 17 22.15 ml/min 0.85 3.52 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16132 381
FHH-Chr 12BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 11 13.9 ml/min/kg 0.58 1.91 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57589 526
FHH-Chr 12BN/Mcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 11 28.38 ml/min 1.68 5.57 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16681 381
FHH-Chr 12BN/Mcwi tidal volume controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 17 0.37 ml 0.01 0.04 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16458 381
FHH-Chr 12BN/Mcwi tidal volume controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 0.39 ml 0.02 0.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16464 381
FHH-Chr 12BN/Mcwi body weight control condition (for 14 days) PhysGen Lung data body mass male 77 days-91 days 12 226.5 g 7.3 25.2 whole body digital scale 0 Moms and pups used in studies were fed Teklad 58337 526
FHH-Chr 12BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 12 0.01 umol/l 0.0 0.01 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54880 522
FHH-Chr 12BN/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 3 6.0 % 3.06 5.29 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55130 522
FHH-Chr 12BN/Mcwi tidal volume controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 0.35 ml 0.01 0.04 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 17361 381
FHH-Chr 12BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 22 10.05 ml/min/g 0.55 2.58 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46855 461
FHH-Chr 12BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 14 10.71 ml/min/g 0.51 1.92 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46638 461
FHH-Chr 12BN/Mcwi left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 5 103.38 mmHg 3.21 7.19 balloon tipped catheter with pressure transducer in isolated perfused heart 0 46741 461
FHH-Chr 12BN/Mcwi left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 19 47.56 mmHg 3.76 16.41 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47692 461
FHH-Chr 12BN/Mcwi body weight control condition PhysGen Cardiac data body mass female 49 days-63 days 22 139.2 g 4.7 22.2 whole body digital scale 0 Moms and pups used in studies were fed Teklad 47787 461
FHH-Chr 12BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 15 post-ischemic value/pre-ischemic value x 100% 70.13 % 8.72 33.78 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48280 461
FHH-Chr 12BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 19 6.32 ml/min/g 0.69 3.0 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46192 461
FHH-Chr 12BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 21 0.4 IU/g 0.05 0.23 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47280 461
FHH-Chr 12BN/Mcwi percent change in heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 20 post-ischemic value/pre-ischemic value x 100% 105.43 % 17.47 78.11 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48397 461
FHH-Chr 12BN/Mcwi urine sodium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine sodium amount female 80 days-99 days 10 12.16 mEq/d 2.29 7.24 flame atomic emission spectrometry 0 Moms were fed Teklad, pups used in studies were fed Dyets 52780 482
FHH-Chr 12BN/Mcwi heart rate controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 15 369.98 beats/min 6.96 26.95 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14672 381
FHH-Chr 12BN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 12 -6.89 mmHg 0.78 2.71 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19607 381
FHH-Chr 12BN/Mcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 17 0.24 ml 0.01 0.04 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15382 381
FHH-Chr 12BN/Mcwi body temperature control condition PhysGen Respiratory data body temperature trait female 82 days-99 days 17 37.22 degrees C 0.12 0.51 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 19054 381
FHH-Chr 12BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 5.91 mmHg 0.17 0.54 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47188 461
FHH-Chr 12BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine albumin amount female 80 days-99 days 10 45.57 mg/d 19.51 61.71 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52386 482
FHH-Chr 12BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount female 80 days-99 days 7 0.36 mg/dl 0.04 0.11 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52243 482
FHH-Chr 12BN/Mcwi percent change in left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 6 post-ischemic value/pre-ischemic value x 100% 49.03 % 9.3 22.78 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46304 461
FHH-Chr 12BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 59.57 mmHg 5.75 18.17 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46408 461
FHH-Chr 12BN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 11 54.45 % 4.67 15.49 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57214 522
FHH-Chr 12BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 143.49 mmHg 10.46 31.39 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45720 461
FHH-Chr 12BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 20 8.4 ml/min/g 0.4 1.79 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46861 461
FHH-Chr 12BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 11 24.09 mmol/l 0.67 2.21 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38252 401
FHH-Chr 12BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77 days-91 days 12 0.67 x 1000 cells/ul 0.06 0.21 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43209 401
FHH-Chr 12BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77 days-91 days 12 56.97 fl 0.18 0.62 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38730 401
FHH-Chr 12BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 17 0.01 umol/l 0.0 0.01 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54896 522
FHH-Chr 12BN/Mcwi time to onset of heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 21 995.9 s 35.99 164.94 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50110 461
FHH-Chr 12BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77 days-91 days 12 21.25 mg/dl 0.66 2.3 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40813 401
FHH-Chr 12BN/Mcwi sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 11 99.45 % 0.28 0.93 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56473 522
FHH-Chr 12BN/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 10 20.3 % 4.35 13.77 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55053 522
FHH-Chr 12BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77 days-91 days 11 55.15 % 0.58 1.93 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59248 526
FHH-Chr 12BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77 days-91 days 12 8.28 mg/dl 0.22 0.77 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37579 401
FHH-Chr 12BN/Mcwi lung dry weight to body weight ratio control condition (for 14 days) PhysGen Lung data lung mass male 77 days-91 days 12 1.0 g/kg 0.02 0.07 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59453 526
FHH-Chr 12BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 11 5.58 x 1000 cells/ul 0.44 1.47 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40917 401
FHH-Chr 12BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 12 24.86 ml/min/kg 1.05 3.64 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57785 526
FHH-Chr 12BN/Mcwi minute ventilation controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 61.34 ml/min 5.17 16.33 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14491 381
FHH-Chr 12BN/Mcwi mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 11 125.99 mmHg 3.59 11.91 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 15076 381
FHH-Chr 12BN/Mcwi heart rate controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 10 330.03 beats/min 14.67 46.39 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14682 381
FHH-Chr 12BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount female 82 days-99 days 12 30.63 mmHg 0.54 1.88 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17214 381
FHH-Chr 12BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 11 103.43 % 8.23 27.29 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53975 381
FHH-Chr 12BN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 12 0.06 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19757 381
FHH-Chr 12BN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 11 0.04 null 0.0 0.02 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19768 381
FHH-Chr 12BN/Mcwi heart rate control condition PhysGen Respiratory data heart pumping trait male 82 days-99 days 11 415.2 beats/min 13.22 43.84 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 20905 381
FHH-Chr 12BN/Mcwi mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 15 116.61 mmHg 4.2 16.27 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 19840 381
FHH-Chr 12BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 11 412.27 U/l 8.23 27.3 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36370 401
FHH-Chr 12BN/Mcwi urine potassium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine potassium amount male 80 days-99 days 11 1.07 mEq/d 0.06 0.21 flame atomic emission spectrometry 0 urine potassium analysis Moms were fed Teklad, pups used in studies were fed Dyets 52311 482
FHH-Chr 12BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data renin activity female 80 days-99 days 7 7.44 ng/ml/h 1.44 3.8 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52878 482
FHH-Chr 12BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount female 77 days-91 days 12 9.75 mg/dl 0.09 0.32 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36609 401
FHH-Chr 12BN/Mcwi mean corpuscular hemoglobin concentration control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 12 32.02 g/dl 0.14 0.49 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 37327 401
FHH-Chr 12BN/Mcwi percent change in ventilation controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 19 %change=VE during7-9 min hypercapnia/control during standard conditions 126.57 % 7.89 34.39 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18528 381
FHH-Chr 12BN/Mcwi serum alkaline phosphatase activity level control condition (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77 days-91 days 11 240.91 U/l 9.71 32.19 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37433 401
FHH-Chr 12BN/Mcwi serum calcium level control condition (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 12 10.06 mg/dl 0.16 0.57 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36758 401
FHH-Chr 12BN/Mcwi heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 22 214.21 beats/min 13.53 63.48 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48930 461
FHH-Chr 12BN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 11 -46.57 mmHg 2.47 8.2 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19447 381
FHH-Chr 12BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 12 55.69 mmHg 1.25 4.32 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20447 381
FHH-Chr 12BN/Mcwi left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 19 5.55 mmHg 0.22 0.97 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49162 461
FHH-Chr 12BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 11 -0.34 degrees C 0.11 0.36 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20300 381
FHH-Chr 12BN/Mcwi blood neutrophil count control condition (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77 days-91 days 12 0.97 x 1000 cells/ul 0.09 0.32 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38895 401
FHH-Chr 12BN/Mcwi blood neutrophil count control condition (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77 days-91 days 11 0.51 x 1000 cells/ul 0.1 0.33 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38879 401
FHH-Chr 12BN/Mcwi serum total bilirubin level control condition (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77 days-91 days 11 0.11 mg/dl 0.01 0.03 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42866 401
FHH-Chr 12BN/Mcwi plasma creatinine level control condition (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77 days-91 days 11 0.18 mg/dl 0.02 0.06 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 42629 401
FHH-Chr 12BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77 days-91 days 12 82.08 U/l 2.68 9.28 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42755 401
FHH-Chr 12BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 11 91.82 U/l 3.43 11.39 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42761 401
FHH-Chr 12BN/Mcwi serum total bilirubin level control condition (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 12 0.1 mg/dl 0.0 0.0 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42882 401
FHH-Chr 12BN/Mcwi total white blood cell count control condition (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77 days-91 days 11 3.65 x 1000 cells/ul 0.24 0.8 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39868 401
FHH-Chr 12BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 11 0.28 mg/dl 0.01 0.04 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39567 401
FHH-Chr 12BN/Mcwi serum bicarbonate level control condition (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 12 19.83 mmol/l 1.4 4.84 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42989 401
FHH-Chr 12BN/Mcwi blood monocyte count control condition (for 14 days) PhysGen Biochemistry data monocyte quantity female 77 days-91 days 11 0.21 x 1000 cells/ul 0.05 0.17 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40277 401
FHH-Chr 12BN/Mcwi mean corpuscular hemoglobin control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 11 17.44 pg 0.16 0.55 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40181 401
FHH-Chr 12BN/Mcwi serum potassium level control condition (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 11 4.77 mmol/l 0.11 0.37 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 43326 401
FHH-Chr 12BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 11 2.1 g/dl 0.05 0.17 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40541 401
FHH-Chr 12BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 11 17.8 g/dl 0.18 0.58 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 37959 401
FHH-Chr 12BN/Mcwi hematocrit control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 12 43.73 % 1.02 3.52 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41301 401
FHH-Chr 12BN/Mcwi blood eosinophil count control condition (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77 days-91 days 11 0.04 x 1000 cells/ul 0.01 0.04 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41387 401
FHH-Chr 12BN/Mcwi serum globulin level control condition (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 12 2.01 g/dl 0.05 0.18 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 41026 401
FHH-Chr 12BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount female 77 days-91 days 12 159.75 mg/dl 4.42 15.32 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38515 401
FHH-Chr 12BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount male 77 days-91 days 11 150.18 mg/dl 6.18 20.5 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38521 401
FHH-Chr 12BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 18 7.35 g/kg 0.2 0.85 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45590 461
FHH-Chr 12BN/Mcwi mean corpuscular volume control condition (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77 days-91 days 11 54.08 fl 0.2 0.67 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38630 401
FHH-Chr 12BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 10 26.38 IU/g 3.42 10.8 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 48838 461
FHH-Chr 12BN/Mcwi hematocrit control condition (for 14 days) PhysGen Lung data erythrocyte quantity male 77 days-91 days 12 43.73 % 1.02 3.52 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 57486 526
FHH-Chr 12BN/Mcwi maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 12 1.31 g/mg 0.14 0.49 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57308 522
FHH-Chr 12BN/Mcwi maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 17 1.16 g/mg 0.09 0.36 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57324 522
FHH-Chr 12BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 12 45.28 ml/min/kg 1.36 4.72 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57984 526
FHH-Chr 12BN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 11 -7.15 null 0.05 0.16 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55615 522
FHH-Chr 12BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 12 -8.28 null 0.21 0.74 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 56079 522
FHH-Chr 12BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 17 -8.49 null 0.16 0.66 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 56095 522
FHH-Chr 12BN/Mcwi concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 3 0.07 10E-7mol/l 0.05 0.08 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56227 522
FHH-Chr 12BN/Mcwi concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 7 0.05 10E-7mol/l 0.01 0.04 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56238 522
FHH-Chr 12BN/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 3 15.33 % 4.1 7.09 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56270 522
FHH-Chr 12BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 11 0.01 umol/l 0.0 0.01 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54648 522
FHH-Chr 12BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 11 20.54 ml/min/kg 0.78 2.6 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58622 526
FHH-Chr 12BN/Mcwi concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 3 0.04 10E-7mol/l 0.01 0.01 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55732 522
FHH-Chr 12BN/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 7 31.86 % 2.67 7.06 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57144 522
FHH-Chr 12BN/Mcwi heart contraction pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 21 40.57 mmHg 2.31 10.57 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48024 461
FHH-Chr 12BN/Mcwi body weight control condition PhysGen Cardiac data body mass male 49 days-63 days 22 163.0 g 6.9 32.2 whole body digital scale 0 Moms and pups used in studies were fed Teklad 47803 461
FHH-Chr 12BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 22 6.55 ml/min/g 0.57 2.66 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46186 461
FHH-Chr 12BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 12 post-ischemic value/pre-ischemic value x 100% 89.28 % 19.25 66.69 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48286 461
FHH-Chr 12BN/Mcwi percent change in left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 5 post-ischemic value/pre-ischemic value x 100% 75.4 % 19.31 43.17 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 44909 461
FHH-Chr 12BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 21 0.39 IU/g 0.04 0.21 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47296 461
FHH-Chr 12BN/Mcwi mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 17 127.74 mmHg 4.23 17.45 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 15064 381
FHH-Chr 12BN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 11 -4.05 mmHg 0.64 2.12 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19618 381
FHH-Chr 12BN/Mcwi respiration rate controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 10 148.15 breaths/min 4.62 14.6 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 17102 381
FHH-Chr 12BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 11 119.18 mmHg 4.58 15.19 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14314 381
FHH-Chr 12BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount male 82 days-99 days 11 30.22 mmHg 0.8 2.67 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17226 381
FHH-Chr 12BN/Mcwi serum total protein level control condition (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 12 5.6 g/dl 0.13 0.44 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37197 401
FHH-Chr 12BN/Mcwi mean arterial blood pressure controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data arterial blood pressure trait female 80 days-99 days 11 163.84 mmHg 7.46 24.74 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52531 482
FHH-Chr 12BN/Mcwi creatinine clearance controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data glomerular filtration trait female 80 days-99 days 7 1.1 ml/min 0.19 0.5 urine creatinine analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52339 482
FHH-Chr 12BN/Mcwi creatinine clearance controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data glomerular filtration trait male 80 days-99 days 10 1.33 ml/min 0.14 0.44 urine creatinine analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52358 482
FHH-Chr 12BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 14 50.37 mmHg 5.31 19.87 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45255 461
FHH-Chr 12BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 12 11.57 ml/min/g 0.41 1.43 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46644 461
FHH-Chr 12BN/Mcwi left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 22 97.97 mmHg 3.82 17.93 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 44800 461
FHH-Chr 12BN/Mcwi left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 19 52.11 mmHg 4.17 18.17 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47902 461
FHH-Chr 12BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 11 2.29 E-7mole 0.56 1.86 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55868 522
FHH-Chr 12BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 11 2.18 mg/kg 0.48 1.6 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58897 526
FHH-Chr 12BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 14 102.81 mmHg 5.11 19.13 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49873 461
FHH-Chr 12BN/Mcwi percent change in respiration rate controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 17 173.59 % 7.37 30.4 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53617 381
FHH-Chr 12BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 12 240.81 beats/min 10.48 36.32 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47573 461
FHH-Chr 12BN/Mcwi percent change in ventilation controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 17 %change=VE during 2-3 min hypercapnia/control during standard conditions 267.82 % 11.48 47.35 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 19196 381
FHH-Chr 12BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 12 51.08 % 0.54 1.87 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38976 401
FHH-Chr 12BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 11 55.15 % 0.58 1.93 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38982 401
FHH-Chr 12BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77 days-91 days 11 21.64 mg/dl 0.95 3.14 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40819 401
FHH-Chr 12BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity female 77 days-91 days 12 51.08 % 0.54 1.87 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59242 526
FHH-Chr 12BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 12 0.19 mmHg x min x kg x ml-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59532 526
FHH-Chr 12BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount female 77 days-91 days 12 111.08 mmol/l 0.26 0.9 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39102 401
FHH-Chr 12BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 11 110.64 mmol/l 0.36 1.21 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39108 401
FHH-Chr 12BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 14.74 ml/min/kg 1.19 3.76 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 59977 526
FHH-Chr 12BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 10 21.34 ml/min/kg 0.88 2.8 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57791 526
FHH-Chr 12BN/Mcwi heart right ventricle weight to left ventricle weight ratio control condition (for 14 days) PhysGen Lung data heart right ventricle mass female 77 days-91 days 12 0.24 null 0.01 0.03 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 57884 526
FHH-Chr 12BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 11 0.25 ml 0.02 0.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15224 381
FHH-Chr 12BN/Mcwi absolute change in body temperature controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 17 -0.35 degrees C 0.12 0.48 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 15654 381
FHH-Chr 12BN/Mcwi mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 10 119.12 mmHg 2.99 9.44 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 19850 381
FHH-Chr 12BN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 12 7.48 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17020 381
FHH-Chr 12BN/Mcwi respiration rate control condition PhysGen Respiratory data respiratory function trait female 82 days-99 days 19 92.0 breaths/min 3.0 13.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18395 381
FHH-Chr 12BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 12 5.93 g/dl 0.04 0.13 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36947 401
FHH-Chr 12BN/Mcwi partial pressure of blood oxygen control condition PhysGen Respiratory data blood oxygen amount male 82 days-99 days 11 103.06 mmHg 3.37 11.17 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 18851 381
FHH-Chr 12BN/Mcwi percent change in tidal volume controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 17 154.81 % 3.65 15.05 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54068 381
FHH-Chr 12BN/Mcwi mean arterial blood pressure controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 10 115.03 mmHg 2.48 7.83 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 13469 381
FHH-Chr 12BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 19 116.49 breaths/min 4.28 18.65 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14779 381
FHH-Chr 12BN/Mcwi percent change in ventilation controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 %change=VE during7-9 min hypercapnia/control during standard conditions 189.43 % 10.79 34.12 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14189 381
FHH-Chr 12BN/Mcwi respiration rate controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 17 157.17 breaths/min 5.8 23.9 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16896 381
FHH-Chr 12BN/Mcwi body weight control condition PhysGen Respiratory data body mass female 82 days-99 days 19 177.3 g 2.6 11.5 whole body digital scale 0 Moms and pups used in studies were fed Dyets 17802 381
FHH-Chr 12BN/Mcwi serum alkaline phosphatase activity level control condition (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 12 365.58 U/l 11.9 41.23 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37449 401
FHH-Chr 12BN/Mcwi blood lymphocyte count control condition (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77 days-91 days 11 2.89 x 1000 cells/ul 0.22 0.71 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 36852 401
FHH-Chr 12BN/Mcwi serum calcium level control condition (for 14 days) PhysGen Biochemistry data blood calcium amount female 77 days-91 days 11 9.47 mg/dl 0.12 0.38 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36742 401
FHH-Chr 12BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 19 28.0 ml/min 0.84 3.65 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18647 381
FHH-Chr 12BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 19 116.69 breaths/min 4.07 17.75 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18250 381
FHH-Chr 12BN/Mcwi heart wet weight control condition PhysGen Cardiac data heart mass female 49 days-63 days 21 0.73 g 0.03 0.14 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49045 461
FHH-Chr 12BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 106.78 mmHg 9.73 30.76 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49879 461
FHH-Chr 12BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 12 1139.92 s 62.15 215.29 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50218 461
FHH-Chr 12BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 11 55.58 fl 0.18 0.61 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38736 401
FHH-Chr 12BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77 days-91 days 12 0.26 mg/dl 0.02 0.07 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39561 401
FHH-Chr 12BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 11 1.93 mg/kg 0.35 1.16 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58891 526
FHH-Chr 12BN/Mcwi mean corpuscular hemoglobin control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 12 16.76 pg 0.08 0.29 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40197 401
FHH-Chr 12BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 11 2.74 mg/kg 0.26 0.85 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59164 526
FHH-Chr 12BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 11 114.12 % 3.95 13.11 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54315 381
FHH-Chr 12BN/Mcwi serum alanine aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77 days-91 days 11 51.36 U/l 2.39 7.92 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37690 401
FHH-Chr 12BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass female 77 days-91 days 12 1.77 g/kg 0.03 0.1 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59642 526
FHH-Chr 12BN/Mcwi serum total cholesterol level control condition (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77 days-91 days 11 90.0 mg/dl 2.43 8.06 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38416 401
FHH-Chr 12BN/Mcwi left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 7 115.52 mmHg 5.96 15.78 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45489 461
FHH-Chr 12BN/Mcwi mean corpuscular volume control condition (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 12 52.35 fl 0.17 0.58 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38646 401
FHH-Chr 12BN/Mcwi red blood cell count control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 11 7.84 x 10E6 cells/ul 0.15 0.51 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41952 401
FHH-Chr 12BN/Mcwi hematocrit control condition (for 14 days) PhysGen Lung data erythrocyte quantity female 77 days-91 days 11 42.43 % 0.82 2.71 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 57470 526
FHH-Chr 12BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 8 22.77 IU/g 2.45 6.93 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 48849 461
FHH-Chr 12BN/Mcwi body weight control condition (for 21 days) PhysGen Vascular data body mass male 70 days-84 days 11 261.0 g 9.2 30.5 whole body digital scale 0 Moms and pups used in studies were fed Teklad 55407 522
FHH-Chr 12BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 19 36.58 degrees C 0.4 1.76 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16557 381
FHH-Chr 12BN/Mcwi concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 11 0.06 10E-7mol/l 0.01 0.02 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55743 522
FHH-Chr 12BN/Mcwi maximum contractile force per wet weight of aorta potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 11 1.27 g/mg 0.06 0.21 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55778 522
FHH-Chr 12BN/Mcwi body temperature control condition PhysGen Respiratory data body temperature trait female 82 days-99 days 19 36.87 degrees C 0.38 1.64 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16797 381
FHH-Chr 12BN/Mcwi logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 11 -8.28 null 0.04 0.14 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54617 522
FHH-Chr 12BN/Mcwi logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 7 -8.41 null 0.1 0.26 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56026 522
FHH-Chr 12BN/Mcwi body weight controlled sodium content diet (4 %) (for 21 days) PhysGen Vascular data body mass female 70 days-84 days 13 180.7 g 1.7 6.1 whole body digital scale 0 Moms and pups used in studies were fed Teklad 55159 522
FHH-Chr 12BN/Mcwi body weight controlled sodium content diet (4 %) (for 21 days) PhysGen Vascular data body mass male 70 days-84 days 17 247.3 g 4.9 20.4 whole body digital scale 0 Moms and pups used in studies were fed Teklad 55173 522
FHH-Chr 12BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass female 77 days-91 days 12 0.49 null 0.02 0.07 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58718 526
FHH-Chr 12BN/Mcwi calculated pulmonary vascular resistance normalized to body weight Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 11 0.11 mmHg x min x kg x ml-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59871 526
FHH-Chr 12BN/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 3 30.0 % 2.31 4.0 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57133 522
FHH-Chr 12BN/Mcwi tidal volume controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 17 0.36 ml 0.01 0.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 17355 381
FHH-Chr 12BN/Mcwi left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 22 48.37 mmHg 3.76 17.64 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47896 461
FHH-Chr 12BN/Mcwi heart contraction pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 22 42.55 mmHg 2.45 11.51 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48018 461
FHH-Chr 12BN/Mcwi percent change in left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 7 post-ischemic value/pre-ischemic value x 100% 88.59 % 6.47 17.12 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 44903 461
FHH-Chr 12BN/Mcwi heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 22 254.62 beats/min 7.85 36.81 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48182 461
FHH-Chr 12BN/Mcwi minute ventilation controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 17 50.59 ml/min 2.24 9.24 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20746 381
FHH-Chr 12BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 11 32.71 ml/min 2.41 7.99 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20199 381
FHH-Chr 12BN/Mcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 19 0.23 ml 0.01 0.04 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 17967 381
FHH-Chr 12BN/Mcwi percent change in left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 5 post-ischemic value/pre-ischemic value x 100% 42.81 % 12.58 28.12 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46310 461
FHH-Chr 12BN/Mcwi percent change in heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 22 post-ischemic value/pre-ischemic value x 100% 85.53 % 5.42 25.43 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48391 461
FHH-Chr 12BN/Mcwi left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 6 110.46 mmHg 7.18 17.6 balloon tipped catheter with pressure transducer in isolated perfused heart 0 46735 461
FHH-Chr 12BN/Mcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 19 21.46 ml/min 1.05 4.56 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16675 381
FHH-Chr 12BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77 days-91 days 12 21.92 mmol/l 0.87 3.0 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38246 401
FHH-Chr 12BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 11 4.4 x 1000 cells/ul 0.39 1.28 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41494 401
FHH-Chr 12BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 12 0.55 null 0.02 0.08 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58098 526
FHH-Chr 12BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 9 0.5 null 0.04 0.11 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58104 526
FHH-Chr 12BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass female 49 days-63 days 18 138.3 g 2.1 8.7 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49492 461
FHH-Chr 12BN/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 10 52.7 % 2.58 8.15 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57176 522
FHH-Chr 12BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 21 9.88 % 1.37 6.26 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49381 461
FHH-Chr 12BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 19 5.47 % 1.56 6.8 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49387 461
FHH-Chr 12BN/Mcwi percent change in tidal volume controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 137.27 % 7.63 24.13 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54414 381
FHH-Chr 12BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 12 43.25 mmHg 3.84 13.32 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49988 461
FHH-Chr 12BN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 16 60.88 % 4.67 18.66 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54770 522
FHH-Chr 12BN/Mcwi logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 3 -8.44 null 0.1 0.17 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54606 522
FHH-Chr 12BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 16 9.38 % 3.21 12.83 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49683 461
FHH-Chr 12BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 18 1.01 g 0.02 0.1 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45390 461
FHH-Chr 12BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 12 1.21 g 0.04 0.13 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45396 461
FHH-Chr 12BN/Mcwi left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 5 108.7 mmHg 3.14 7.01 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45495 461
FHH-Chr 12BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77 days-91 days 11 0.91 x 1000 cells/ul 0.11 0.36 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43215 401
FHH-Chr 12BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 16 262.5 beats/min 10.58 42.31 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47567 461
FHH-Chr 12BN/Mcwi sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 7 99.14 % 0.7 1.86 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56313 522
FHH-Chr 12BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 5 111.93 mmHg 2.53 5.66 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48609 461
FHH-Chr 12BN/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 3 12.33 % 3.38 5.86 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55042 522
FHH-Chr 12BN/Mcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 28.37 ml/min 2.42 7.65 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16138 381
FHH-Chr 12BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 12 1.57 E-7mole 0.18 0.63 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56494 522
FHH-Chr 12BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 11 3.77 g/dl 0.03 0.1 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42224 401
FHH-Chr 12BN/Mcwi hematocrit control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 11 42.43 % 0.82 2.71 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41285 401
FHH-Chr 12BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount female 77 days-91 days 12 143.58 mmol/l 0.26 0.9 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39373 401