FHH-Chr 10BN/Mcwi |
logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) |
phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70 days-84 days |
5 |
-6.61 |
null |
0.14 |
0.31 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
Moms and pups used in studies were fed Teklad |
55621 |
522 |
FHH-Chr 10BN/Mcwi |
acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70 days-84 days |
9 |
72.89 |
% |
3.39 |
10.18 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
Moms and pups used in studies were fed Teklad |
54788 |
522 |
FHH-Chr 10BN/Mcwi |
concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
male |
70 days-84 days |
10 |
0.02 |
umol/l |
0.0 |
0.01 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
Moms and pups used in studies were fed Teklad |
54914 |
522 |
FHH-Chr 10BN/Mcwi |
concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) |
phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
female |
70 days-84 days |
7 |
0.01 |
umol/l |
0.0 |
0.0 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
Moms and pups used in studies were fed Teklad |
54670 |
522 |
FHH-Chr 10BN/Mcwi |
acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70 days-84 days |
8 |
57.5 |
% |
7.15 |
20.21 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
Moms and pups used in studies were fed Teklad |
57232 |
522 |
FHH-Chr 10BN/Mcwi |
logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) |
phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70 days-84 days |
8 |
-6.54 |
null |
0.07 |
0.19 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
Moms and pups used in studies were fed Teklad |
55633 |
522 |
FHH-Chr 10BN/Mcwi |
logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
male |
70 days-84 days |
10 |
-7.81 |
null |
0.08 |
0.26 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
EC50 value is moles/liter |
Moms and pups used in studies were fed Teklad |
56113 |
522 |
FHH-Chr 10BN/Mcwi |
dose of methacholine at which pulmonary conductance is half its pretreatment value |
controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) |
PhysGen Lung data |
pulmonary ventilation trait |
female |
77 days-91 days |
9 |
1.7 |
mg/kg |
0.41 |
1.24 |
stop flow air displacement plethysmography |
|
0 |
|
Moms and pups used in studies were fed Teklad |
58899 |
526 |
FHH-Chr 10BN/Mcwi |
logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70 days-84 days |
10 |
-6.82 |
null |
0.04 |
0.12 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
Moms and pups used in studies were fed Teklad |
56911 |
522 |
FHH-Chr 10BN/Mcwi |
logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) |
phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
male |
70 days-84 days |
10 |
-8.31 |
null |
0.05 |
0.16 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
EC50 value is moles/liter |
Moms and pups used in studies were fed Teklad |
55283 |
522 |
FHH-Chr 10BN/Mcwi |
concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) |
phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70 days-84 days |
5 |
2.98 |
E-7mole |
0.83 |
1.85 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
Moms and pups used in studies were fed Teklad |
55890 |
522 |
FHH-Chr 10BN/Mcwi |
concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) |
phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70 days-84 days |
8 |
3.1 |
E-7mole |
0.48 |
1.36 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
Moms and pups used in studies were fed Teklad |
55902 |
522 |
FHH-Chr 10BN/Mcwi |
concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
female |
70 days-84 days |
10 |
0.01 |
umol/l |
0.0 |
0.01 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
Moms and pups used in studies were fed Teklad |
54902 |
522 |
FHH-Chr 10BN/Mcwi |
acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70 days-84 days |
10 |
73.5 |
% |
4.84 |
15.31 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
Moms and pups used in studies were fed Teklad |
54776 |
522 |
FHH-Chr 10BN/Mcwi |
dose of methacholine at which pulmonary conductance is half its pretreatment value |
controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) |
PhysGen Lung data |
pulmonary ventilation trait |
male |
77 days-91 days |
6 |
2.21 |
mg/kg |
0.55 |
1.35 |
stop flow air displacement plethysmography |
|
0 |
|
Moms and pups used in studies were fed Teklad |
58905 |
526 |
FHH-Chr 10BN/Mcwi |
logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70 days-84 days |
9 |
-6.8 |
null |
0.07 |
0.21 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
Moms and pups used in studies were fed Teklad |
56923 |
522 |
FHH-Chr 10BN/Mcwi |
acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70 days-84 days |
5 |
43.2 |
% |
12.27 |
27.44 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
Moms and pups used in studies were fed Teklad |
57220 |
522 |
FHH-Chr 10BN/Mcwi |
dose of methacholine at which pulmonary conductance is half its pretreatment value |
methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) |
PhysGen Lung data |
pulmonary ventilation trait |
female |
77 days-91 days |
5 |
3.25 |
mg/kg |
1.29 |
2.88 |
stop flow air displacement plethysmography |
|
0 |
|
Moms and pups used in studies were fed Teklad |
59170 |
526 |
FHH-Chr 10BN/Mcwi |
dose of methacholine at which pulmonary conductance is half its pretreatment value |
methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) |
PhysGen Lung data |
pulmonary ventilation trait |
male |
77 days-91 days |
6 |
2.19 |
mg/kg |
0.43 |
1.05 |
stop flow air displacement plethysmography |
|
0 |
|
Moms and pups used in studies were fed Teklad |
59181 |
526 |
FHH-Chr 10BN/Mcwi |
logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
female |
70 days-84 days |
10 |
-7.94 |
null |
0.09 |
0.28 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
EC50 value is moles/liter |
Moms and pups used in studies were fed Teklad |
56101 |
522 |
FHH-Chr 10BN/Mcwi |
concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70 days-84 days |
9 |
1.76 |
E-7mole |
0.28 |
0.83 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
Moms and pups used in studies were fed Teklad |
56528 |
522 |
FHH-Chr 10BN/Mcwi |
concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) |
phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
male |
70 days-84 days |
10 |
0.01 |
umol/l |
0.0 |
0.0 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
Moms and pups used in studies were fed Teklad |
54682 |
522 |
FHH-Chr 10BN/Mcwi |
logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) |
phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
female |
70 days-84 days |
7 |
-8.37 |
null |
0.12 |
0.32 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
EC50 value is moles/liter |
Moms and pups used in studies were fed Teklad |
55271 |
522 |
FHH-Chr 10BN/Mcwi |
concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70 days-84 days |
10 |
1.58 |
E-7mole |
0.15 |
0.47 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
Moms and pups used in studies were fed Teklad |
56516 |
522 |