Phenominer Database Results (464 results)

 
 
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Strain Phenotype Conditions Study Experiment Name Sex Age # of Animals Formula Average Type Value Units SEM SD Method Method Site Method Duration Post Insult Type Post Insult Time Value Post Insult Time Unit Method Notes Clinical Measurement Notes Experiment Notes Record ID Study ID
SS-Chr 13BN/Mcwi partial pressure of blood carbon dioxide (Pco2) resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 7 33.13 mmHg 0.67 1.77 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 14465 381
SS-Chr 13BN/Mcwi minute ventilation controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 9 78.63 ml/min 4.93 14.79 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 14507 381
SS-Chr 13BN/Mcwi heart rate controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 7 419.34 beats/min 15.43 40.82 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 14712 381
SS-Chr 13BN/Mcwi heart rate control condition PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 7 456.56 beats/min 10.43 27.59 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 15942 381
SS-Chr 13BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 10 0.32 ml 0.05 0.14 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 15240 381
SS-Chr 13BN/Mcwi respiration rate control condition PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 9 97.17 breaths/min 3.37 10.1 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 14947 381
SS-Chr 13BN/Mcwi mean arterial blood pressure controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data arterial blood pressure trait male 80.0 days-99.0 days 18 143.27 mmHg 0.95 4.05 vascular fluid filled catheter Moms were fed Teklad, pups used in studies were fed Dyets 52855 482
SS-Chr 13BN/Mcwi urine potassium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine potassium amount female 80.0 days-99.0 days 20 0.76 mEq/d 0.05 0.24 flame atomic emission spectrometry urine potassium analysis Moms were fed Teklad, pups used in studies were fed Dyets 52949 482
SS-Chr 13BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data renin activity female 80.0 days-99.0 days 17 1.13 ng/ml/h 0.29 1.2 radioimmunoassay Moms were fed Teklad, pups used in studies were fed Dyets 52457 482
SS-Chr 13BN/Mcwi urine total protein excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data total urine protein amount male 80.0 days-99.0 days 16 75.43 mg/d 8.18 32.71 automated urine total protein analysis Moms were fed Teklad, pups used in studies were fed Dyets 52706 482
SS-Chr 13BN/Mcwi percent change in respiration rate controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 9 170.28 % 6.62 19.86 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 54234 381
SS-Chr 13BN/Mcwi mean arterial blood pressure controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 8 116.97 mmHg 2.46 6.96 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 13506 381
SS-Chr 13BN/Mcwi body temperature controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 9 37.99 degrees C 0.24 0.73 digital rectal thermometry Moms and pups used in studies were fed Teklad 13566 381
SS-Chr 13BN/Mcwi percent change in ventilation controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 9 %change=VE during7-9 min hypercapnia/control during standard conditions 253.41 % 22.58 67.74 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 14205 381
SS-Chr 13BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 8 120.5 mmHg 4.3 12.17 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 14352 381
SS-Chr 13BN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 7 7.54 null 0.02 0.05 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17063 381
SS-Chr 13BN/Mcwi respiration rate controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 9 156.39 breaths/min 4.99 14.96 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 17118 381
SS-Chr 13BN/Mcwi heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 9 488.0 beats/min 17.43 52.29 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 13792 381
SS-Chr 13BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 10 0.34 ml 0.05 0.15 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 13930 381
SS-Chr 13BN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 8 0.07 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 19806 381
SS-Chr 13BN/Mcwi mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 8 114.63 mmHg 2.94 8.31 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 19887 381
SS-Chr 13BN/Mcwi minute ventilation controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 9 67.71 ml/min 3.81 11.43 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 20768 381
SS-Chr 13BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 9 120.16 % 8.49 25.46 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 53768 381
SS-Chr 13BN/Mcwi mean arterial blood pressure resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 7 99.45 mmHg 3.74 9.9 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 20048 381
SS-Chr 13BN/Mcwi blood pH resting on treadmill (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 7 7.45 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 20154 381
SS-Chr 13BN/Mcwi blood pH control condition PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 8 7.47 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 20638 381
SS-Chr 13BN/Mcwi body weight control condition PhysGen Respiratory data body mass male 82.0 days-99.0 days 9 275.0 g 7.6 22.8 whole body digital scale Moms and pups used in studies were fed Dyets 17829 381
SS-Chr 13BN/Mcwi body temperature resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 10 38.02 degrees C 0.13 0.42 digital rectal thermometry Moms and pups used in studies were fed Teklad 18121 381
SS-Chr 13BN/Mcwi partial pressure of blood oxygen control condition PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 8 108.43 mmHg 2.84 8.03 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 18889 381
SS-Chr 13BN/Mcwi mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 7 119.25 mmHg 4.64 12.28 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 18941 381
SS-Chr 13BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77.0 days-91.0 days 12 6.57 g/dl 0.04 0.15 standard blood chemistry panel Moms and pups used in studies were fed Teklad 36969 401
SS-Chr 13BN/Mcwi mean corpuscular hemoglobin concentration control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77.0 days-91.0 days 12 32.13 g/dl 0.11 0.39 automated blood cell counting method Moms and pups used in studies were fed Teklad 37362 401
SS-Chr 13BN/Mcwi body temperature control condition PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 9 38.04 degrees C 0.23 0.7 digital rectal thermometry Moms and pups used in studies were fed Teklad 19081 381
SS-Chr 13BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 10 41.73 ml/min 5.93 18.74 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 18669 381
SS-Chr 13BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 8 417.99 beats/min 12.93 36.58 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 17525 381
SS-Chr 13BN/Mcwi serum sodium level control condition (for 14 days) PhysGen Biochemistry data blood sodium amount male 77.0 days-91.0 days 11 145.55 mmol/l 0.41 1.37 standard blood chemistry panel Moms and pups used in studies were fed Teklad 36533 401
SS-Chr 13BN/Mcwi serum calcium level control condition (for 14 days) PhysGen Biochemistry data blood calcium amount male 77.0 days-91.0 days 11 9.56 mg/dl 0.14 0.48 standard blood chemistry panel Moms and pups used in studies were fed Teklad 36802 401
SS-Chr 13BN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 7 -48.86 mmHg 3.58 9.48 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 19478 381
SS-Chr 13BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 9 131.42 breaths/min 8.08 24.24 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 18277 381
SS-Chr 13BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49.0 days-63.0 days 19 956.68 s 47.46 206.88 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 49311 461
SS-Chr 13BN/Mcwi time to onset of heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49.0 days-63.0 days 17 913.59 s 42.45 175.02 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 50131 461
SS-Chr 13BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 19 1214.0 s 37.6 163.9 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 50239 461
SS-Chr 13BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount male 77.0 days-91.0 days 11 109.73 mmol/l 1.0 3.32 standard blood chemistry panel Moms and pups used in studies were fed Teklad 39129 401
SS-Chr 13BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77.0 days-91.0 days 12 8.95 x 10E6 cells/ul 0.12 0.42 automated blood cell counting method Moms and pups used in studies were fed Teklad 39244 401
SS-Chr 13BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity female 77.0 days-91.0 days 12 0.33 x 1000 cells/ul 0.06 0.2 automated blood cell counting method Moms and pups used in studies were fed Teklad 39681 401
SS-Chr 13BN/Mcwi serum total bilirubin level control condition (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77.0 days-91.0 days 12 0.1 mg/dl 0.0 0.0 standard blood chemistry panel Moms and pups used in studies were fed Teklad 42917 401
SS-Chr 13BN/Mcwi serum total bilirubin level control condition (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77.0 days-91.0 days 11 0.1 mg/dl 0.0 0.0 standard blood chemistry panel Moms and pups used in studies were fed Teklad 42926 401
SS-Chr 13BN/Mcwi serum bicarbonate level control condition (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77.0 days-91.0 days 12 22.33 mmol/l 0.63 2.19 standard blood chemistry panel Moms and pups used in studies were fed Teklad 43024 401
SS-Chr 13BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 9 130.79 % 9.3 27.9 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 54341 381
SS-Chr 13BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77.0 days-91.0 days 12 32.0 g/dl 0.23 0.8 automated blood cell counting method Moms and pups used in studies were fed Teklad 39784 401
SS-Chr 13BN/Mcwi serum chloride level control condition (for 14 days) PhysGen Biochemistry data blood chloride amount female 77.0 days-91.0 days 12 106.25 mmol/l 0.51 1.76 standard blood chemistry panel Moms and pups used in studies were fed Teklad 40040 401
SS-Chr 13BN/Mcwi serum chloride level control condition (for 14 days) PhysGen Biochemistry data blood chloride amount male 77.0 days-91.0 days 11 105.27 mmol/l 0.47 1.56 standard blood chemistry panel Moms and pups used in studies were fed Teklad 40049 401
SS-Chr 13BN/Mcwi percent change in respiration rate controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 9 170.0 % 5.32 15.95 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 53649 381
SS-Chr 13BN/Mcwi mean corpuscular hemoglobin control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77.0 days-91.0 days 12 19.13 pg 0.09 0.32 automated blood cell counting method Moms and pups used in studies were fed Teklad 40232 401
SS-Chr 13BN/Mcwi serum albumin level control condition (for 14 days) PhysGen Biochemistry data blood albumin amount male 77.0 days-91.0 days 11 3.92 g/dl 0.04 0.12 standard blood chemistry panel Moms and pups used in studies were fed Teklad 40450 401
SS-Chr 13BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount female 77.0 days-91.0 days 12 2.38 g/dl 0.03 0.1 standard blood chemistry panel replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40557 401
SS-Chr 13BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77.0 days-91.0 days 12 17.5 mg/dl 0.6 2.07 standard blood chemistry panel Moms and pups used in studies were fed Teklad 40835 401
SS-Chr 13BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77.0 days-91.0 days 10 0.06 mmHg-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung Moms and pups used in studies were fed Teklad 59401 526
SS-Chr 13BN/Mcwi serum alanine aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77.0 days-91.0 days 11 57.09 U/l 3.58 11.89 standard blood chemistry panel Moms and pups used in studies were fed Teklad 37750 401
SS-Chr 13BN/Mcwi hematocrit control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77.0 days-91.0 days 12 43.72 % 0.55 1.89 automated blood cell counting method Moms and pups used in studies were fed Teklad 41336 401
SS-Chr 13BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77.0 days-91.0 days 11 27.73 mmol/l 1.87 6.2 standard blood chemistry panel Moms and pups used in studies were fed Teklad 38273 401
SS-Chr 13BN/Mcwi blood eosinophil count control condition (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77.0 days-91.0 days 11 0.01 x 1000 cells/ul 0.01 0.02 automated blood cell counting method Moms and pups used in studies were fed Teklad 41447 401
SS-Chr 13BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77.0 days-91.0 days 12 4.25 x 1000 cells/ul 0.18 0.64 automated blood cell counting method Moms and pups used in studies were fed Teklad 41510 401
SS-Chr 13BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77.0 days-91.0 days 12 0.04 x 1000 cells/ul 0.01 0.05 automated blood cell counting method Moms and pups used in studies were fed Teklad 41654 401
SS-Chr 13BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount female 77.0 days-91.0 days 12 155.25 mg/dl 6.01 20.82 standard blood chemistry panel Moms and pups used in studies were fed Teklad 38537 401
SS-Chr 13BN/Mcwi time to peak heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 10 1221.8 s 39.17 123.87 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 46555 461
SS-Chr 13BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 14 post-ischemic value/pre-ischemic value x 100% 66.77 % 8.5 31.81 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48768 461
SS-Chr 13BN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 9 36.33 % 2.58 7.75 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 57258 522
SS-Chr 13BN/Mcwi maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait female 70.0 days-84.0 days 15 0.87 g/mg 0.1 0.38 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 57359 522
SS-Chr 13BN/Mcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 9 27.9 ml/min 2.13 6.39 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 16154 381
SS-Chr 13BN/Mcwi body weight control condition (for 21 days) PhysGen Vascular data body mass female 70.0 days-84.0 days 11 176.4 g 10.8 35.8 whole body digital scale Moms and pups used in studies were fed Teklad 55439 522
SS-Chr 13BN/Mcwi heart right ventricle weight to left ventricle weight ratio control condition (for 14 days) PhysGen Lung data heart right ventricle mass male 77.0 days-91.0 days 11 0.26 null 0.01 0.03 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 57944 526
SS-Chr 13BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 9 37.44 degrees C 0.14 0.43 digital rectal thermometry Moms and pups used in studies were fed Teklad 16584 381
SS-Chr 13BN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 8 -6.79 null 0.06 0.17 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 55650 522
SS-Chr 13BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 11 0.42 null 0.02 0.07 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 58120 526
SS-Chr 13BN/Mcwi FAPGG metabolism-surface area product FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 9 55.95 ml/min/kg 3.58 10.73 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 58260 526
SS-Chr 13BN/Mcwi body temperature control condition PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 9 38.11 degrees C 0.22 0.65 digital rectal thermometry Moms and pups used in studies were fed Teklad 16824 381
SS-Chr 13BN/Mcwi maximum contractile force per wet weight of aorta potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait female 70.0 days-84.0 days 11 1.71 g/mg 0.08 0.27 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 55813 522
SS-Chr 13BN/Mcwi maximum contractile force per wet weight of aorta potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait male 70.0 days-84.0 days 9 1.37 g/mg 0.08 0.24 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 55822 522
SS-Chr 13BN/Mcwi body weight control condition (for 14 days) PhysGen Lung data body mass male 77.0 days-91.0 days 11 276.2 g 8.7 28.7 whole body digital scale Moms and pups used in studies were fed Teklad 58381 526
SS-Chr 13BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70.0 days-84.0 days 15 0.08 umol/l 0.03 0.12 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 54931 522
SS-Chr 13BN/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 10 35.0 % 3.65 11.56 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 55050 522
SS-Chr 13BN/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 9 23.78 % 3.7 11.1 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 55056 522
SS-Chr 13BN/Mcwi sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 11 99.18 % 0.4 1.33 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 56470 522
SS-Chr 13BN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 8 -6.77 null 0.04 0.12 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 56949 522
SS-Chr 13BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49.0 days-63.0 days 22 5.62 g/kg 0.13 0.63 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 45641 461
SS-Chr 13BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49.0 days-63.0 days 19 5.34 g/kg 0.16 0.71 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 45650 461
SS-Chr 13BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49.0 days-63.0 days 17 6.79 ml/min/g 0.39 1.6 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 44730 461
SS-Chr 13BN/Mcwi heart weight to body weight ratio control condition PhysGen Cardiac data heart mass female 49.0 days-63.0 days 10 4.9 g/kg 0.1 0.31 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 47016 461
SS-Chr 13BN/Mcwi left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 9 52.15 mmHg 2.81 8.42 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 47918 461
SS-Chr 13BN/Mcwi left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 9 109.49 mmHg 2.87 8.62 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 44822 461
SS-Chr 13BN/Mcwi percent change in left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 7 post-ischemic value/pre-ischemic value x 100% 80.95 % 5.11 13.51 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 44925 461
SS-Chr 13BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49.0 days-63.0 days 10 4.8 ml/min/g 0.52 1.63 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 46208 461
SS-Chr 13BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49.0 days-63.0 days 17 6.09 ml/min/g 0.36 1.48 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 46213 461
SS-Chr 13BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 16 5.4 mmHg 0.25 1.0 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 47204 461
SS-Chr 13BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 17 226.19 beats/min 6.24 25.74 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 45155 461
SS-Chr 13BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 17 52.0 mmHg 7.09 29.23 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 45282 461
SS-Chr 13BN/Mcwi body weight control condition Stodola TJ, et al., Physiol Genomics. 2011 Jul 14;43(13):808-17. doi: 10.1152/physiolgenomics.00171.2010. Epub 2011 Apr 26. body mass male 49.0 days-63.0 days 15 294.8 g 8.3 32.15 body weighing method 0.0 99005 2198
SS-Chr 13BN/Mcwi mean arterial blood pressure controlled sodium content diet (0.4 %) (for 68 days) then controlled sodium content diet (8 %) (for 21 days) Moreno C, et al., Am J Physiol Heart Circ Physiol. 2011 Apr;300(4):H1530-5. doi: 10.1152/ajpheart.01026.2010. Epub 2011 Jan 21. arterial blood pressure trait male 89.0 days 8 serial mean 146.0 mmHg 6.0 16.97 intra-aortic abdominal radiotelemetry via femoral cannulation 10800.0 98672 2138
SS-Chr 13BN/Mcwi urine total protein excretion rate controlled sodium content diet (0.4 %) (for 68 days) then controlled sodium content diet (8 %) (for 21 days) Moreno C, et al., Am J Physiol Heart Circ Physiol. 2011 Apr;300(4):H1530-5. doi: 10.1152/ajpheart.01026.2010. Epub 2011 Jan 21. total urine protein amount male 89.0 days 9 162.0 mg/d 24.0 72.0 Bradford protein assay 1.0 98686 2138
SS-Chr 13BN/Mcwi mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 10 119.15 mmHg 2.18 6.89 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 15107 381
SS-Chr 13BN/Mcwi absolute change in body temperature controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 9 0.21 degrees C 0.31 0.93 digital rectal thermometry Moms and pups used in studies were fed Teklad 15676 381
SS-Chr 13BN/Mcwi blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 10 7.45 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14593 381
SS-Chr 13BN/Mcwi heart rate control condition PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 8 429.15 beats/min 16.44 46.5 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 15949 381
SS-Chr 13BN/Mcwi absolute change in body temperature resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 7 0.11 degrees C 0.29 0.78 digital rectal thermometry Moms and pups used in studies were fed Teklad 16003 381
SS-Chr 13BN/Mcwi creatinine clearance controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data glomerular filtration trait female 80.0 days-99.0 days 18 1.39 ml/min 0.09 0.38 urine creatinine analysis Moms were fed Teklad, pups used in studies were fed Dyets 52163 482
SS-Chr 13BN/Mcwi creatinine clearance controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data glomerular filtration trait male 80.0 days-99.0 days 15 2.38 ml/min 0.23 0.87 urine creatinine analysis Moms were fed Teklad, pups used in studies were fed Dyets 52167 482
SS-Chr 13BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount male 80.0 days-99.0 days 17 0.33 mg/dl 0.02 0.08 radioimmunoassay Moms were fed Teklad, pups used in studies were fed Dyets 52216 482
SS-Chr 13BN/Mcwi heart rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data heart pumping trait male 80.0 days-99.0 days 18 382.3 beats/min 2.75 11.69 vascular fluid filled catheter Moms were fed Teklad, pups used in studies were fed Dyets 52657 482
SS-Chr 13BN/Mcwi percent change in tidal volume controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 9 172.11 % 5.61 16.82 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 54100 381
SS-Chr 13BN/Mcwi partial pressure of blood carbon dioxide (Pco2) resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 7 29.14 mmHg 0.44 1.15 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 13428 381
SS-Chr 13BN/Mcwi body temperature controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 9 37.76 degrees C 0.21 0.64 digital rectal thermometry Moms and pups used in studies were fed Teklad 13571 381
SS-Chr 13BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 10 108.1 mmHg 6.38 20.19 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 14345 381
SS-Chr 13BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount male 82.0 days-99.0 days 8 26.36 mmHg 0.52 1.47 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 17262 381
SS-Chr 13BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 9 %change=VE during 2-3 min hypoxia/control during standard conditions 156.19 % 12.44 37.33 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 13692 381
SS-Chr 13BN/Mcwi minute ventilation controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 9 73.85 ml/min 5.29 15.87 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 20773 381
SS-Chr 13BN/Mcwi absolute change in partial pressure of blood carbon dioxide resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 7 -3.99 mmHg 0.36 0.94 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 20082 381
SS-Chr 13BN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 8 -6.64 mmHg 0.69 1.94 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 19654 381
SS-Chr 13BN/Mcwi heart rate resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 10 431.31 beats/min 14.74 46.62 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 17735 381
SS-Chr 13BN/Mcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 10 0.28 ml 0.03 0.11 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 17989 381
SS-Chr 13BN/Mcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 9 0.28 ml 0.03 0.09 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 17994 381
SS-Chr 13BN/Mcwi mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 9 110.29 mmHg 4.18 12.53 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 18936 381
SS-Chr 13BN/Mcwi blood lymphocyte count control condition (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77.0 days-91.0 days 12 4.4 x 1000 cells/ul 0.32 1.12 automated blood cell counting method Moms and pups used in studies were fed Teklad 36903 401
SS-Chr 13BN/Mcwi serum total protein level control condition (for 14 days) PhysGen Biochemistry data blood total protein amount male 77.0 days-91.0 days 11 6.2 g/dl 0.08 0.26 standard blood chemistry panel Moms and pups used in studies were fed Teklad 37241 401
SS-Chr 13BN/Mcwi serum alkaline phosphatase activity level control condition (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77.0 days-91.0 days 12 116.75 U/l 7.95 27.53 standard blood chemistry panel Moms and pups used in studies were fed Teklad 37484 401
SS-Chr 13BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77.0 days-91.0 days 11 9.87 mg/dl 0.1 0.32 standard blood chemistry panel Moms and pups used in studies were fed Teklad 36636 401
SS-Chr 13BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 10 123.41 breaths/min 8.67 27.43 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 18272 381
SS-Chr 13BN/Mcwi heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 9 187.34 beats/min 10.73 32.18 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48952 461
SS-Chr 13BN/Mcwi left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 15 5.28 mmHg 0.27 1.05 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 49189 461
SS-Chr 13BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49.0 days-63.0 days 21 967.9 s 27.23 124.76 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 49306 461
SS-Chr 13BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77.0 days-91.0 days 11 19.75 pg 0.25 0.82 automated blood cell counting method Moms and pups used in studies were fed Teklad 42557 401
SS-Chr 13BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount female 77.0 days-91.0 days 12 145.33 mmol/l 0.73 2.53 standard blood chemistry panel Moms and pups used in studies were fed Teklad 39395 401
SS-Chr 13BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77.0 days-91.0 days 11 145.64 mmol/l 1.04 3.44 standard blood chemistry panel Moms and pups used in studies were fed Teklad 39400 401
SS-Chr 13BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77.0 days-91.0 days 11 79.27 U/l 8.27 27.43 standard blood chemistry panel Moms and pups used in studies were fed Teklad 42782 401
SS-Chr 13BN/Mcwi total white blood cell count control condition (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77.0 days-91.0 days 12 5.03 x 1000 cells/ul 0.34 1.17 automated blood cell counting method Moms and pups used in studies were fed Teklad 39919 401
SS-Chr 13BN/Mcwi plasma anion gap control condition (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77.0 days-91.0 days 11 22.91 mmol/l 0.68 2.26 standard blood chemistry panel Moms and pups used in studies were fed Teklad 43174 401
SS-Chr 13BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77.0 days-91.0 days 12 0.56 x 1000 cells/ul 0.08 0.26 automated blood cell counting method Moms and pups used in studies were fed Teklad 43231 401
SS-Chr 13BN/Mcwi serum potassium level control condition (for 14 days) PhysGen Biochemistry data blood potassium amount male 77.0 days-91.0 days 11 4.75 mmol/l 0.11 0.37 standard blood chemistry panel Moms and pups used in studies were fed Teklad 43370 401
SS-Chr 13BN/Mcwi mean corpuscular hemoglobin control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77.0 days-91.0 days 11 18.59 pg 0.08 0.26 automated blood cell counting method Moms and pups used in studies were fed Teklad 40241 401
SS-Chr 13BN/Mcwi serum albumin level control condition (for 14 days) PhysGen Biochemistry data blood albumin amount female 77.0 days-91.0 days 12 4.23 g/dl 0.05 0.16 standard blood chemistry panel Moms and pups used in studies were fed Teklad 40441 401
SS-Chr 13BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77.0 days-91.0 days 11 1.39 mg/kg 0.19 0.64 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 59198 526
SS-Chr 13BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity female 77.0 days-91.0 days 12 55.92 % 0.58 2.03 microhematocrit tube assay with visual assessment Moms and pups used in studies were fed Teklad 59264 526
SS-Chr 13BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77.0 days-91.0 days 11 18.73 mg/dl 0.9 2.97 standard blood chemistry panel Moms and pups used in studies were fed Teklad 40840 401
SS-Chr 13BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77.0 days-91.0 days 11 6.53 x 1000 cells/ul 0.41 1.37 automated blood cell counting method Moms and pups used in studies were fed Teklad 40938 401
SS-Chr 13BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 12 0.15 mmHg x min x kg x ml-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung Moms and pups used in studies were fed Teklad 59554 526
SS-Chr 13BN/Mcwi serum phosphate level control condition (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77.0 days-91.0 days 11 7.85 mg/dl 0.16 0.52 standard blood chemistry panel Moms and pups used in studies were fed Teklad 37861 401
SS-Chr 13BN/Mcwi serum phosphate level control condition (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77.0 days-91.0 days 11 8.44 mg/dl 0.11 0.37 standard blood chemistry panel Moms and pups used in studies were fed Teklad 37870 401
SS-Chr 13BN/Mcwi serum globulin level control condition (for 14 days) PhysGen Biochemistry data blood globulin amount female 77.0 days-91.0 days 12 2.04 g/dl 0.03 0.11 standard blood chemistry panel replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 41061 401
SS-Chr 13BN/Mcwi serum globulin level control condition (for 14 days) PhysGen Biochemistry data blood globulin amount male 77.0 days-91.0 days 11 2.28 g/dl 0.05 0.18 standard blood chemistry panel replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 41070 401
SS-Chr 13BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass male 77.0 days-91.0 days 11 1.13 g/kg 0.02 0.06 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 59669 526
SS-Chr 13BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass female 77.0 days-91.0 days 12 1.48 g/kg 0.05 0.16 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 59664 526
SS-Chr 13BN/Mcwi blood eosinophil count control condition (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77.0 days-91.0 days 12 0.02 x 1000 cells/ul 0.01 0.05 automated blood cell counting method Moms and pups used in studies were fed Teklad 41438 401
SS-Chr 13BN/Mcwi serum urea nitrogen level control condition (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77.0 days-91.0 days 12 14.92 mg/dl 0.7 2.43 standard blood chemistry panel Moms and pups used in studies were fed Teklad 41786 401
SS-Chr 13BN/Mcwi mean corpuscular volume control condition (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77.0 days-91.0 days 11 57.45 fl 0.2 0.65 automated blood cell counting method Moms and pups used in studies were fed Teklad 38690 401
SS-Chr 13BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77.0 days-91.0 days 12 0.11 mg/dl 0.01 0.03 standard blood chemistry panel Moms and pups used in studies were fed Teklad 41875 401
SS-Chr 13BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77.0 days-91.0 days 11 0.1 mg/dl 0.0 0.0 standard blood chemistry panel Moms and pups used in studies were fed Teklad 41880 401
SS-Chr 13BN/Mcwi red blood cell count control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77.0 days-91.0 days 12 7.34 x 10E6 cells/ul 0.1 0.33 automated blood cell counting method Moms and pups used in studies were fed Teklad 42003 401
SS-Chr 13BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49.0 days-63.0 days 22 0.87 g 0.02 0.1 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 45412 461
SS-Chr 13BN/Mcwi left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 7 139.47 mmHg 6.72 17.78 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 45511 461
SS-Chr 13BN/Mcwi left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 11 120.63 mmHg 4.72 15.66 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 45516 461
SS-Chr 13BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49.0 days-63.0 days 21 0.44 IU/g 0.06 0.28 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 47468 461
SS-Chr 13BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 11 post-ischemic value/pre-ischemic value x 100% 49.11 % 5.58 18.5 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48534 461
SS-Chr 13BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49.0 days-63.0 days 9 30.61 IU/g 3.05 9.15 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 48888 461
SS-Chr 13BN/Mcwi hematocrit control condition (for 14 days) PhysGen Lung data erythrocyte quantity female 77.0 days-91.0 days 11 43.48 % 0.54 1.79 microhematocrit tube assay with visual assessment Moms and pups used in studies were fed Teklad 57521 526
SS-Chr 13BN/Mcwi absolute change in partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 7 12.43 mmHg 4.63 12.25 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 16285 381
SS-Chr 13BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 12 21.75 ml/min/kg 0.55 1.92 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 57807 526
SS-Chr 13BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 10 15.64 ml/min/kg 0.45 1.41 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 57812 526
SS-Chr 13BN/Mcwi partial pressure of blood oxygen resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 7 103.62 mmHg 3.47 9.17 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 16399 381
SS-Chr 13BN/Mcwi heart right ventricle weight to left ventricle weight ratio control condition (for 14 days) PhysGen Lung data heart right ventricle mass female 77.0 days-91.0 days 12 0.23 null 0.01 0.04 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 57935 526
SS-Chr 13BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 11 52.49 ml/min/kg 2.39 7.94 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 58006 526
SS-Chr 13BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 10 36.43 degrees C 0.57 1.79 digital rectal thermometry Moms and pups used in studies were fed Teklad 16579 381
SS-Chr 13BN/Mcwi concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 10 0.04 10E-7mol/l 0.01 0.03 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 55740 522
SS-Chr 13BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 10 0.42 null 0.02 0.06 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 58125 526
SS-Chr 13BN/Mcwi body temperature control condition PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 10 37.12 degrees C 0.66 2.1 digital rectal thermometry Moms and pups used in studies were fed Teklad 16819 381
SS-Chr 13BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 9 3.06 E-7mole 0.56 1.67 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 55928 522
SS-Chr 13BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70.0 days-84.0 days 11 0.02 umol/l 0.0 0.01 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 54699 522
SS-Chr 13BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70.0 days-84.0 days 9 0.02 umol/l 0.0 0.01 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 54708 522
SS-Chr 13BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77.0 days-91.0 days 10 0.05 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung Moms and pups used in studies were fed Teklad 58501 526
SS-Chr 13BN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 14 89.5 % 2.32 8.7 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 54805 522
SS-Chr 13BN/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 10 26.2 % 2.45 7.76 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 55138 522
SS-Chr 13BN/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 9 24.0 % 2.43 7.28 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 55144 522
SS-Chr 13BN/Mcwi sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 9 99.22 % 0.57 1.72 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 56476 522
SS-Chr 13BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 14 2.15 E-7mole 0.98 3.66 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 56545 522
SS-Chr 13BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 9 0.37 null 0.03 0.08 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 59806 526
SS-Chr 13BN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 14 -7.03 null 0.11 0.42 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 56940 522
SS-Chr 13BN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 8 47.38 % 6.24 17.66 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 57249 522
SS-Chr 13BN/Mcwi tidal volume controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 9 0.44 ml 0.03 0.09 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 17377 381
SS-Chr 13BN/Mcwi partial pressure of blood carbon dioxide (Pco2) control condition PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 8 33.38 mmHg 0.89 2.53 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 16082 381
SS-Chr 13BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49.0 days-63.0 days 10 10.15 ml/min/g 0.64 2.02 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 46877 461
SS-Chr 13BN/Mcwi percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49.0 days-63.0 days 10 post-ischemic value/pre-ischemic value x 100% 48.23 % 5.55 17.55 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 46073 461
SS-Chr 13BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49.0 days-63.0 days 19 post-ischemic value/pre-ischemic value x 100% 54.4 % 2.4 10.47 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 47084 461
SS-Chr 13BN/Mcwi heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 18 255.65 beats/min 7.65 32.47 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48209 461
SS-Chr 13BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 17 post-ischemic value/pre-ischemic value x 100% 89.31 % 3.62 14.92 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48302 461
SS-Chr 13BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 19 post-ischemic value/pre-ischemic value x 100% 76.6 % 6.66 29.03 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48307 461
SS-Chr 13BN/Mcwi partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 10 116.11 mmHg 3.7 11.71 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 15039 381
SS-Chr 13BN/Mcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 9 0.29 ml 0.02 0.05 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 15404 381
SS-Chr 13BN/Mcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 9 0.27 ml 0.02 0.07 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 15409 381
SS-Chr 13BN/Mcwi minute ventilation controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 9 75.71 ml/min 4.77 14.3 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 14512 381
SS-Chr 13BN/Mcwi absolute change in body temperature resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 10 0.38 degrees C 0.19 0.59 digital rectal thermometry Moms and pups used in studies were fed Teklad 15998 381
SS-Chr 13BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 9 0.32 ml 0.04 0.13 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 15245 381
SS-Chr 13BN/Mcwi respiration rate control condition PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 9 96.53 breaths/min 7.4 22.2 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 14942 381
SS-Chr 13BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount female 80.0 days-99.0 days 18 0.35 mg/dl 0.02 0.07 radioimmunoassay Moms were fed Teklad, pups used in studies were fed Dyets 52212 482
SS-Chr 13BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine albumin amount male 80.0 days-99.0 days 16 10.59 mg/d 2.08 8.32 radioimmunoassay Moms were fed Teklad, pups used in studies were fed Dyets 52606 482
SS-Chr 13BN/Mcwi urine sodium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine sodium amount female 80.0 days-99.0 days 20 8.83 mEq/d 0.82 3.65 flame atomic emission spectrometry Moms were fed Teklad, pups used in studies were fed Dyets 52753 482
SS-Chr 13BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (for 18 days) Moreno et al. Physiol Genomics 2007 Oct 22;31(2):228-35. Epub 2007 Jun 12. urine albumin amount male 84.0 days-88.0 days 12 21.4 mg/d 3.0 10.39 urine analysis 86400 65202 15
SS-Chr 13BN/Mcwi heart rate controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 8 375.78 beats/min 13.65 38.61 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 14719 381
SS-Chr 13BN/Mcwi mean arterial blood pressure controlled sodium content diet (8 %) (between 16 and 19 days) Moreno et al. Physiol Genomics 2007 Oct 22;31(2):228-35. Epub 2007 Jun 12. arterial blood pressure trait female 86.0 days-89.0 days 12 137.0 mmHg 1.9 6.58 vascular fluid filled catheter left femoral artery 14400 on 3 consecutive days 5403 15
SS-Chr 13BN/Mcwi partial pressure of blood carbon dioxide (Pco2) resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 10 29.12 mmHg 0.74 2.35 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 13423 381
SS-Chr 13BN/Mcwi mean arterial blood pressure controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 7 112.41 mmHg 5.67 15.0 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 13499 381
SS-Chr 13BN/Mcwi respiration rate controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 9 164.66 breaths/min 6.41 19.22 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 17123 381
SS-Chr 13BN/Mcwi heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 7 446.53 beats/min 11.09 29.33 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 13797 381
SS-Chr 13BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 9 0.34 ml 0.05 0.14 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 13935 381
SS-Chr 13BN/Mcwi absolute change in mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 9 13.36 mmHg 2.76 8.29 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 20721 381
SS-Chr 13BN/Mcwi heart rate control condition PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 8 438.51 beats/min 17.08 48.32 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 20943 381
SS-Chr 13BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 10 116.4 % 9.12 28.83 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 53994 381
SS-Chr 13BN/Mcwi blood pH resting on treadmill (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 10 7.47 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 20149 381
SS-Chr 13BN/Mcwi body temperature resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 7 38.34 degrees C 0.26 0.7 digital rectal thermometry Moms and pups used in studies were fed Teklad 17642 381
SS-Chr 13BN/Mcwi body weight control condition PhysGen Respiratory data body mass female 82.0 days-99.0 days 11 185.9 g 4.1 13.7 whole body digital scale Moms and pups used in studies were fed Dyets 17824 381
SS-Chr 13BN/Mcwi body temperature resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 7 38.23 degrees C 0.09 0.24 digital rectal thermometry Moms and pups used in studies were fed Teklad 18126 381
SS-Chr 13BN/Mcwi respiration rate controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 9 174.09 breaths/min 5.07 15.21 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 16918 381
SS-Chr 13BN/Mcwi partial pressure of blood oxygen control condition PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 8 105.78 mmHg 3.8 10.76 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 18882 381
SS-Chr 13BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77.0 days-91.0 days 11 6.8 g/dl 0.07 0.22 standard blood chemistry panel Moms and pups used in studies were fed Teklad 36974 401
SS-Chr 13BN/Mcwi serum total protein level control condition (for 14 days) PhysGen Biochemistry data blood total protein amount female 77.0 days-91.0 days 12 6.28 g/dl 0.06 0.2 standard blood chemistry panel Moms and pups used in studies were fed Teklad 37232 401
SS-Chr 13BN/Mcwi body temperature control condition PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 9 37.78 degrees C 0.23 0.68 digital rectal thermometry Moms and pups used in studies were fed Teklad 19076 381
SS-Chr 13BN/Mcwi percent change in ventilation controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 9 %change=VE during7-9 min hypercapnia/control during standard conditions 138.16 % 10.7 32.09 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 18555 381
SS-Chr 13BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount female 77.0 days-91.0 days 12 9.39 mg/dl 0.13 0.44 standard blood chemistry panel Moms and pups used in studies were fed Teklad 36631 401
SS-Chr 13BN/Mcwi serum calcium level control condition (for 14 days) PhysGen Biochemistry data blood calcium amount female 77.0 days-91.0 days 12 9.33 mg/dl 0.11 0.37 standard blood chemistry panel Moms and pups used in studies were fed Teklad 36793 401
SS-Chr 13BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 10 40.54 ml/min 6.65 21.03 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 20215 381
SS-Chr 13BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 10 -0.69 degrees C 0.29 0.92 digital rectal thermometry Moms and pups used in studies were fed Teklad 20316 381
SS-Chr 13BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 9 -0.67 degrees C 0.32 0.96 digital rectal thermometry Moms and pups used in studies were fed Teklad 20321 381
SS-Chr 13BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 7 55.98 mmHg 1.51 3.98 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 20490 381
SS-Chr 13BN/Mcwi heart wet weight control condition PhysGen Cardiac data heart mass female 49.0 days-63.0 days 10 0.77 g 0.03 0.09 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 49067 461
SS-Chr 13BN/Mcwi heart wet weight control condition PhysGen Cardiac data heart mass male 49.0 days-63.0 days 18 0.95 g 0.02 0.1 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 49072 461
SS-Chr 13BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49.0 days-63.0 days 10 14.85 % 3.2 10.11 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 49403 461
SS-Chr 13BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass female 49.0 days-63.0 days 22 155.1 g 3.9 18.3 whole body digital scale Moms and pups used in studies were fed Teklad 49543 461
SS-Chr 13BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 18 103.76 mmHg 5.25 22.27 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 49895 461
SS-Chr 13BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49.0 days-63.0 days 21 46.52 mmHg 2.69 12.35 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 50004 461
SS-Chr 13BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 21 1227.29 s 32.5 148.91 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 50234 461
SS-Chr 13BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77.0 days-91.0 days 12 62.52 fl 0.39 1.35 automated blood cell counting method Moms and pups used in studies were fed Teklad 38752 401
SS-Chr 13BN/Mcwi blood neutrophil count control condition (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77.0 days-91.0 days 11 0.89 x 1000 cells/ul 0.06 0.21 automated blood cell counting method Moms and pups used in studies were fed Teklad 38939 401
SS-Chr 13BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77.0 days-91.0 days 11 3.95 g/dl 0.03 0.1 standard blood chemistry panel Moms and pups used in studies were fed Teklad 42245 401
SS-Chr 13BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77.0 days-91.0 days 11 57.16 % 1.1 3.64 automated blood cell counting method Moms and pups used in studies were fed Teklad 39003 401
SS-Chr 13BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77.0 days-91.0 days 11 9.42 x 10E6 cells/ul 0.14 0.46 automated blood cell counting method Moms and pups used in studies were fed Teklad 39249 401
SS-Chr 13BN/Mcwi serum aspartate aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77.0 days-91.0 days 11 86.45 U/l 6.39 21.21 standard blood chemistry panel Moms and pups used in studies were fed Teklad 42460 401
SS-Chr 13BN/Mcwi plasma creatinine level control condition (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77.0 days-91.0 days 12 0.21 mg/dl 0.01 0.03 automated plasma creatinine analysis Moms and pups used in studies were fed Teklad 42680 401
SS-Chr 13BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77.0 days-91.0 days 12 73.08 U/l 2.55 8.83 standard blood chemistry panel Moms and pups used in studies were fed Teklad 42777 401
SS-Chr 13BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77.0 days-91.0 days 12 0.27 mg/dl 0.02 0.07 automated plasma creatinine analysis Moms and pups used in studies were fed Teklad 39583 401
SS-Chr 13BN/Mcwi total white blood cell count control condition (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77.0 days-91.0 days 11 6.99 x 1000 cells/ul 0.57 1.9 automated blood cell counting method Moms and pups used in studies were fed Teklad 39928 401
SS-Chr 13BN/Mcwi plasma anion gap control condition (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77.0 days-91.0 days 12 20.83 mmol/l 0.53 1.85 standard blood chemistry panel Moms and pups used in studies were fed Teklad 43165 401
SS-Chr 13BN/Mcwi blood hemoglobin level control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77.0 days-91.0 days 11 13.99 g/dl 0.14 0.45 automated blood cell counting method Moms and pups used in studies were fed Teklad 40145 401
SS-Chr 13BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77.0 days-91.0 days 11 1.64 mg/kg 0.21 0.7 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 58918 526
SS-Chr 13BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass female 77.0 days-91.0 days 12 176.6 g 4.5 15.6 whole body digital scale Moms and pups used in studies were fed Teklad 59069 526
SS-Chr 13BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77.0 days-91.0 days 11 50.91 U/l 5.68 18.83 standard blood chemistry panel Moms and pups used in studies were fed Teklad 40726 401
SS-Chr 13BN/Mcwi serum alkaline phosphatase activity level control condition (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77.0 days-91.0 days 11 212.64 U/l 11.48 38.06 standard blood chemistry panel Moms and pups used in studies were fed Teklad 37493 401
SS-Chr 13BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77.0 days-91.0 days 12 8.2 mg/dl 0.19 0.66 standard blood chemistry panel Moms and pups used in studies were fed Teklad 37601 401
SS-Chr 13BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77.0 days-91.0 days 11 9.15 mg/dl 0.18 0.58 standard blood chemistry panel Moms and pups used in studies were fed Teklad 37606 401
SS-Chr 13BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77.0 days-91.0 days 12 5.18 x 1000 cells/ul 0.26 0.91 automated blood cell counting method Moms and pups used in studies were fed Teklad 40933 401
SS-Chr 13BN/Mcwi hematocrit control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77.0 days-91.0 days 11 43.25 % 0.47 1.57 automated blood cell counting method Moms and pups used in studies were fed Teklad 41345 401
SS-Chr 13BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49.0 days-63.0 days 19 1.01 g 0.03 0.15 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 45417 461
SS-Chr 13BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 21 251.89 beats/min 7.46 34.17 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 47589 461
SS-Chr 13BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 12 127.83 mmHg 3.99 13.81 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48631 461
SS-Chr 13BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 13 126.91 mmHg 7.75 27.95 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48636 461
SS-Chr 13BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 14 post-ischemic value/pre-ischemic value x 100% 83.16 % 3.68 13.78 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48763 461
SS-Chr 13BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 10 11.35 ml/min/kg 0.45 1.41 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 57610 526
SS-Chr 13BN/Mcwi body weight controlled sodium content diet (4 %) (for 21 days) PhysGen Vascular data body mass male 70.0 days-84.0 days 10 325.0 g 8.1 25.6 whole body digital scale Moms and pups used in studies were fed Teklad 55213 522
SS-Chr 13BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70.0 days-84.0 days 9 -7.9 null 0.09 0.28 wire myography using a Digi-Med tissue force analysis system with force transducer EC50 value is moles/liter Moms and pups used in studies were fed Teklad 55309 522
SS-Chr 13BN/Mcwi tidal volume controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 9 0.46 ml 0.03 0.09 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 16485 381
SS-Chr 13BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 10 37.61 ml/min/kg 1.89 5.98 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 58011 526
SS-Chr 13BN/Mcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 9 28.32 ml/min 3.23 9.69 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 16702 381
SS-Chr 13BN/Mcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 10 26.71 ml/min 3.41 10.78 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 16697 381
SS-Chr 13BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 8 1.75 E-7mole 0.25 0.69 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 55919 522
SS-Chr 13BN/Mcwi FAPGG metabolism-surface area product FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 10 33.3 ml/min/kg 2.05 6.5 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 58269 526
SS-Chr 13BN/Mcwi logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 10 -8.47 null 0.08 0.26 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 54614 522
SS-Chr 13BN/Mcwi logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 9 -8.2 null 0.09 0.27 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 54620 522
SS-Chr 13BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70.0 days-84.0 days 15 -7.41 null 0.12 0.47 wire myography using a Digi-Med tissue force analysis system with force transducer EC50 value is moles/liter Moms and pups used in studies were fed Teklad 56130 522
SS-Chr 13BN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 8 65.63 % 7.7 21.78 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 54814 522
SS-Chr 13BN/Mcwi calculated pulmonary vascular resistance normalized to body weight Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 10 0.13 mmHg x min x kg x ml-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung Moms and pups used in studies were fed Teklad 59931 526
SS-Chr 13BN/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 10 51.4 % 3.21 10.16 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 57173 522
SS-Chr 13BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 17 132.52 mmHg 3.46 14.26 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 45736 461
SS-Chr 13BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 14 134.84 mmHg 6.73 25.19 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 45741 461
SS-Chr 13BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49.0 days-63.0 days 21 12.34 ml/min/g 0.35 1.63 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 46660 461
SS-Chr 13BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49.0 days-63.0 days 19 11.92 ml/min/g 0.53 2.32 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 46665 461
SS-Chr 13BN/Mcwi left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 7 126.36 mmHg 9.16 24.23 balloon tipped catheter with pressure transducer in isolated perfused heart 46757 461
SS-Chr 13BN/Mcwi left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 11 111.69 mmHg 5.61 18.6 balloon tipped catheter with pressure transducer in isolated perfused heart 46762 461
SS-Chr 13BN/Mcwi left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 17 53.74 mmHg 4.1 16.92 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 47713 461
SS-Chr 13BN/Mcwi left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 17 45.84 mmHg 4.42 18.21 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 47923 461
SS-Chr 13BN/Mcwi percent change in left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 10 post-ischemic value/pre-ischemic value x 100% 90.56 % 3.55 11.21 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 44930 461
SS-Chr 13BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49.0 days-63.0 days 19 post-ischemic value/pre-ischemic value x 100% 52.69 % 6.13 26.74 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 47089 461
SS-Chr 13BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 16 4.93 mmHg 0.3 1.19 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 47209 461
SS-Chr 13BN/Mcwi percent change in left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 11 post-ischemic value/pre-ischemic value x 100% 47.92 % 5.55 18.41 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 46331 461
SS-Chr 13BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 18 45.68 mmHg 3.88 16.47 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 46424 461
SS-Chr 13BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49.0 days-63.0 days 10 0.39 IU/g 0.06 0.19 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 47332 461
SS-Chr 13BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49.0 days-63.0 days 17 0.34 IU/g 0.03 0.14 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 47341 461
SS-Chr 13BN/Mcwi percent change in heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 9 post-ischemic value/pre-ischemic value x 100% 80.36 % 3.88 11.63 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48413 461
SS-Chr 13BN/Mcwi extensor digitorum longus muscle weight to body weight ratio common peroneal nerve direct electrical stimulation (3 V) (for 8 hours) Stodola TJ, et al., Physiol Genomics. 2011 Jul 14;43(13):808-17. doi: 10.1152/physiolgenomics.00171.2010. Epub 2011 Apr 26. skeletal muscle mass male 56.0 days-70.0 days 15 EDL/BW 0.44 mg/g 0.01 0.04 ex vivo method 0.0 TA or EDL muscle weight body weight ratio 99034 2198
SS-Chr 13BN/Mcwi tibialis anterior muscle weight to body weight ratio control condition (for 7 days) Stodola TJ, et al., Physiol Genomics. 2011 Jul 14;43(13):808-17. doi: 10.1152/physiolgenomics.00171.2010. Epub 2011 Apr 26. skeletal muscle mass male 56.0 days-70.0 days 15 TA/BW 1.81 mg/g 0.02 0.08 ex vivo method 0.0 TA or EDL muscle weight body weight ratio 99035 2198
SS-Chr 13BN/Mcwi mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 8 120.02 mmHg 2.02 5.71 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 15114 381
SS-Chr 13BN/Mcwi absolute change in body temperature controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 9 -0.29 degrees C 0.16 0.48 digital rectal thermometry Moms and pups used in studies were fed Teklad 15681 381
SS-Chr 13BN/Mcwi partial pressure of blood carbon dioxide (Pco2) resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 10 31.59 mmHg 0.88 2.78 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 14460 381
SS-Chr 13BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 10 123.48 breaths/min 6.22 19.68 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 14801 381
SS-Chr 13BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 9 120.57 breaths/min 7.13 21.4 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 14806 381
SS-Chr 13BN/Mcwi urine potassium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine potassium amount male 80.0 days-99.0 days 16 1.06 mEq/d 0.09 0.35 flame atomic emission spectrometry urine potassium analysis Moms were fed Teklad, pups used in studies were fed Dyets 52953 482
SS-Chr 13BN/Mcwi heart rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data heart pumping trait female 80.0 days-99.0 days 17 408.19 beats/min 2.95 12.16 vascular fluid filled catheter Moms were fed Teklad, pups used in studies were fed Dyets 52653 482
SS-Chr 13BN/Mcwi urine total protein excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data total urine protein amount female 80.0 days-99.0 days 20 63.79 mg/d 6.53 29.18 automated urine total protein analysis Moms were fed Teklad, pups used in studies were fed Dyets 52702 482
SS-Chr 13BN/Mcwi urine sodium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine sodium amount male 80.0 days-99.0 days 16 11.92 mEq/d 1.33 5.31 flame atomic emission spectrometry Moms were fed Teklad, pups used in studies were fed Dyets 52757 482
SS-Chr 13BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (for 18 days) Moreno et al. Physiol Genomics 2007 Oct 22;31(2):228-35. Epub 2007 Jun 12. urine albumin amount female 84.0 days-88.0 days 12 15.9 mg/d 2.1 7.27 urine analysis 86400 65203 15
SS-Chr 13BN/Mcwi absolute change in blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 10 -0.01 null 0.01 0.03 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 14754 381
SS-Chr 13BN/Mcwi absolute change in blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 7 -0.01 null 0.01 0.03 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 14759 381
SS-Chr 13BN/Mcwi absolute change in heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 9 heart rate during walking-heart rate during rest 56.11 beats/min 9.35 28.04 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 13389 381
SS-Chr 13BN/Mcwi absolute change in heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 7 heart rate during walking-heart rate during rest 59.04 beats/min 10.62 28.1 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 13394 381
SS-Chr 13BN/Mcwi percent change in ventilation controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 9 %change=VE during7-9 min hypercapnia/control during standard conditions 283.39 % 10.38 31.15 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 14210 381
SS-Chr 13BN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 8 7.54 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17070 381
SS-Chr 13BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount female 82.0 days-99.0 days 7 26.53 mmHg 1.11 2.94 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 17255 381
SS-Chr 13BN/Mcwi mammary tumor number 7,12-dimethyltetraphene (65 mg/kg) (for 105 days) Adamovic T, et al., Genes Chromosomes Cancer. 2010 Nov;49(11):1035-45 mammary gland integrity trait female 152.0 days-162.0 days 13 5.33 null 1.21 4.38 necropsy 0 DMBA oral gavage 105 days necropsy 11501 86
SS-Chr 13BN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 7 0.07 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 19799 381
SS-Chr 13BN/Mcwi mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 7 114.2 mmHg 5.68 15.03 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 19880 381
SS-Chr 13BN/Mcwi heart rate control condition PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 10 430.23 beats/min 12.19 38.53 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 20936 381
SS-Chr 13BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 10 129.51 % 5.08 16.08 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 53761 381
SS-Chr 13BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 10 123.97 % 10.12 32.0 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 53893 381
SS-Chr 13BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 9 115.14 % 4.7 14.1 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 54001 381
SS-Chr 13BN/Mcwi mean arterial blood pressure resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 10 98.46 mmHg 2.78 8.8 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 20043 381
SS-Chr 13BN/Mcwi blood pH control condition PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 8 7.47 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 20645 381
SS-Chr 13BN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 7 -7.11 mmHg 1.15 3.04 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 19647 381
SS-Chr 13BN/Mcwi heart rate resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 7 387.5 beats/min 16.73 44.27 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 17740 381
SS-Chr 13BN/Mcwi respiration rate control condition PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 10 96.1 breaths/min 5.14 16.26 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 18417 381
SS-Chr 13BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77.0 days-91.0 days 12 145.25 U/l 7.61 26.38 standard blood chemistry panel Moms and pups used in studies were fed Teklad 36386 401
SS-Chr 13BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77.0 days-91.0 days 11 209.64 U/l 9.25 30.67 standard blood chemistry panel Moms and pups used in studies were fed Teklad 36391 401
SS-Chr 13BN/Mcwi blood lymphocyte count control condition (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77.0 days-91.0 days 11 5.85 x 1000 cells/ul 0.51 1.68 automated blood cell counting method Moms and pups used in studies were fed Teklad 36912 401
SS-Chr 13BN/Mcwi mean corpuscular hemoglobin concentration control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77.0 days-91.0 days 11 32.36 g/dl 0.08 0.27 automated blood cell counting method Moms and pups used in studies were fed Teklad 37371 401
SS-Chr 13BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 9 43.89 ml/min 6.71 20.12 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 18674 381
SS-Chr 13BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 10 380.7 beats/min 11.99 37.92 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 17518 381
SS-Chr 13BN/Mcwi serum sodium level control condition (for 14 days) PhysGen Biochemistry data blood sodium amount female 77.0 days-91.0 days 12 145.25 mmol/l 0.7 2.42 standard blood chemistry panel Moms and pups used in studies were fed Teklad 36524 401
SS-Chr 13BN/Mcwi percent change in ventilation controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 9 %change=VE during 2-3 min hypercapnia/control during standard conditions 292.23 % 23.61 70.82 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 19218 381
SS-Chr 13BN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 8 -53.6 mmHg 2.04 5.77 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 19485 381
SS-Chr 13BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 9 38.81 ml/min 5.79 17.36 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 20220 381
SS-Chr 13BN/Mcwi left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 8 4.62 mmHg 0.38 1.06 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 49184 461
SS-Chr 13BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49.0 days-63.0 days 17 24.77 % 3.32 13.69 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 49408 461
SS-Chr 13BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49.0 days-63.0 days 19 13.96 % 2.84 12.36 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 49705 461
SS-Chr 13BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 17 96.55 mmHg 5.07 20.9 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 49900 461
SS-Chr 13BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77.0 days-91.0 days 11 60.64 fl 0.61 2.03 automated blood cell counting method Moms and pups used in studies were fed Teklad 38757 401
SS-Chr 13BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77.0 days-91.0 days 12 15.0 mmol/l 0.78 2.7 standard blood chemistry panel Moms and pups used in studies were fed Teklad 42069 401
SS-Chr 13BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77.0 days-91.0 days 11 14.0 mmol/l 0.99 3.29 standard blood chemistry panel Moms and pups used in studies were fed Teklad 42074 401
SS-Chr 13BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77.0 days-91.0 days 12 55.92 % 0.58 2.03 automated blood cell counting method Moms and pups used in studies were fed Teklad 38998 401
SS-Chr 13BN/Mcwi serum aspartate aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77.0 days-91.0 days 12 79.08 U/l 6.11 21.16 standard blood chemistry panel Moms and pups used in studies were fed Teklad 42451 401
SS-Chr 13BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 10 130.36 % 11.38 35.98 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 54334 381
SS-Chr 13BN/Mcwi percent change in tidal volume controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 9 149.71 % 6.49 19.47 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 54433 381
SS-Chr 13BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77.0 days-91.0 days 11 32.57 g/dl 0.33 1.1 automated blood cell counting method Moms and pups used in studies were fed Teklad 39789 401
SS-Chr 13BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77.0 days-91.0 days 11 0.69 x 1000 cells/ul 0.1 0.32 automated blood cell counting method Moms and pups used in studies were fed Teklad 43236 401
SS-Chr 13BN/Mcwi blood hemoglobin level control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77.0 days-91.0 days 12 14.03 g/dl 0.15 0.51 automated blood cell counting method Moms and pups used in studies were fed Teklad 40136 401
SS-Chr 13BN/Mcwi serum potassium level control condition (for 14 days) PhysGen Biochemistry data blood potassium amount female 77.0 days-91.0 days 12 4.15 mmol/l 0.1 0.34 standard blood chemistry panel Moms and pups used in studies were fed Teklad 43361 401
SS-Chr 13BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77.0 days-91.0 days 12 1.45 mg/kg 0.3 1.05 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 58913 526
SS-Chr 13BN/Mcwi percent change in respiration rate controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 9 186.93 % 11.56 34.69 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 53642 381
SS-Chr 13BN/Mcwi blood monocyte count control condition (for 14 days) PhysGen Biochemistry data monocyte quantity female 77.0 days-91.0 days 12 0.12 x 1000 cells/ul 0.01 0.04 automated blood cell counting method Moms and pups used in studies were fed Teklad 40328 401
SS-Chr 13BN/Mcwi blood monocyte count control condition (for 14 days) PhysGen Biochemistry data monocyte quantity male 77.0 days-91.0 days 11 0.24 x 1000 cells/ul 0.05 0.17 automated blood cell counting method Moms and pups used in studies were fed Teklad 40337 401
SS-Chr 13BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77.0 days-91.0 days 11 2.85 g/dl 0.05 0.15 standard blood chemistry panel replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40562 401
SS-Chr 13BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 10 0.16 mmHg x min x kg x ml-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung Moms and pups used in studies were fed Teklad 59559 526
SS-Chr 13BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77.0 days-91.0 days 11 18.63 g/dl 0.43 1.43 automated blood cell counting method Moms and pups used in studies were fed Teklad 37980 401
SS-Chr 13BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount female 77.0 days-91.0 days 12 4.97 mmol/l 0.19 0.66 standard blood chemistry panel Moms and pups used in studies were fed Teklad 38073 401
SS-Chr 13BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77.0 days-91.0 days 11 5.65 mmol/l 0.15 0.49 standard blood chemistry panel Moms and pups used in studies were fed Teklad 38078 401
SS-Chr 13BN/Mcwi serum glucose level control condition (for 14 days) PhysGen Biochemistry data blood glucose amount female 77.0 days-91.0 days 12 159.42 mg/dl 5.52 19.13 standard blood chemistry panel Moms and pups used in studies were fed Teklad 41228 401
SS-Chr 13BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77.0 days-91.0 days 11 5.1 x 1000 cells/ul 0.61 2.04 automated blood cell counting method Moms and pups used in studies were fed Teklad 41515 401
SS-Chr 13BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77.0 days-91.0 days 11 0.04 x 1000 cells/ul 0.01 0.05 automated blood cell counting method Moms and pups used in studies were fed Teklad 41659 401
SS-Chr 13BN/Mcwi serum urea nitrogen level control condition (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77.0 days-91.0 days 11 16.0 mg/dl 0.7 2.32 standard blood chemistry panel Moms and pups used in studies were fed Teklad 41795 401
SS-Chr 13BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount male 77.0 days-91.0 days 11 151.09 mg/dl 5.96 19.77 standard blood chemistry panel Moms and pups used in studies were fed Teklad 38542 401
SS-Chr 13BN/Mcwi mean corpuscular volume control condition (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77.0 days-91.0 days 12 59.55 fl 0.28 0.97 automated blood cell counting method Moms and pups used in studies were fed Teklad 38681 401
SS-Chr 13BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 19 244.69 beats/min 7.41 32.28 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 47594 461
SS-Chr 13BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 13 post-ischemic value/pre-ischemic value x 100% 32.27 % 6.9 24.87 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48539 461
SS-Chr 13BN/Mcwi maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait male 70.0 days-84.0 days 7 1.0 g/mg 0.07 0.18 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 57368 522
SS-Chr 13BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 12 14.98 ml/min/kg 0.3 1.06 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 57605 526
SS-Chr 13BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70.0 days-84.0 days 11 -7.71 null 0.05 0.17 wire myography using a Digi-Med tissue force analysis system with force transducer EC50 value is moles/liter Moms and pups used in studies were fed Teklad 55300 522
SS-Chr 13BN/Mcwi partial pressure of blood oxygen resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 10 111.75 mmHg 3.74 11.83 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 16394 381
SS-Chr 13BN/Mcwi concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 9 0.07 10E-7mol/l 0.02 0.05 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 55746 522
SS-Chr 13BN/Mcwi body weight control condition (for 14 days) PhysGen Lung data body mass female 77.0 days-91.0 days 12 187.6 g 4.3 14.8 whole body digital scale Moms and pups used in studies were fed Teklad 58372 526
SS-Chr 13BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 10 20.5 ml/min/kg 1.26 4.0 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 58657 526
SS-Chr 13BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 10 13.84 ml/min/kg 0.79 2.49 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 58666 526
SS-Chr 13BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70.0 days-84.0 days 10 0.01 umol/l 0.0 0.01 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 54940 522
SS-Chr 13BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass female 77.0 days-91.0 days 11 0.4 null 0.01 0.05 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 58740 526
SS-Chr 13BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass male 77.0 days-91.0 days 11 0.42 null 0.02 0.06 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 58745 526
SS-Chr 13BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 9 1.93 E-7mole 0.25 0.75 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 56554 522
SS-Chr 13BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 10 9.56 ml/min/kg 0.63 1.98 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 60037 526
SS-Chr 13BN/Mcwi tidal volume controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 9 0.45 ml 0.03 0.1 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 17382 381
SS-Chr 13BN/Mcwi partial pressure of blood carbon dioxide (Pco2) control condition PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 8 33.0 mmHg 0.7 1.98 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 16089 381
SS-Chr 13BN/Mcwi left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 9 57.34 mmHg 2.82 8.46 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 47708 461
SS-Chr 13BN/Mcwi body weight control condition PhysGen Cardiac data body mass female 49.0 days-63.0 days 10 156.6 g 4.0 12.7 whole body digital scale Moms and pups used in studies were fed Teklad 47838 461
SS-Chr 13BN/Mcwi body weight control condition PhysGen Cardiac data body mass male 49.0 days-63.0 days 18 216.2 g 6.8 28.8 whole body digital scale Moms and pups used in studies were fed Teklad 47847 461
SS-Chr 13BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49.0 days-63.0 days 19 6.62 ml/min/g 0.27 1.18 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 44725 461
SS-Chr 13BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49.0 days-63.0 days 17 10.89 ml/min/g 0.46 1.89 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 46882 461
SS-Chr 13BN/Mcwi heart weight to body weight ratio control condition PhysGen Cardiac data heart mass male 49.0 days-63.0 days 18 4.42 g/kg 0.14 0.59 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 47025 461
SS-Chr 13BN/Mcwi heart contraction pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49.0 days-63.0 days 10 49.4 mmHg 2.17 6.87 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48040 461
SS-Chr 13BN/Mcwi heart contraction pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49.0 days-63.0 days 17 48.59 mmHg 3.63 14.95 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48045 461
SS-Chr 13BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 17 208.04 beats/min 9.84 40.59 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 45160 461
SS-Chr 13BN/Mcwi percent change in heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 17 post-ischemic value/pre-ischemic value x 100% 86.33 % 2.5 10.3 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48418 461
SS-Chr 13BN/Mcwi extensor digitorum longus muscle weight to body weight ratio control condition (for 7 days) Stodola TJ, et al., Physiol Genomics. 2011 Jul 14;43(13):808-17. doi: 10.1152/physiolgenomics.00171.2010. Epub 2011 Apr 26. skeletal muscle mass male 56.0 days-70.0 days 15 EDL/BW 0.42 mg/g 0.01 0.04 ex vivo method 0.0 TA or EDL muscle weight body weight ratio 99033 2198
SS-Chr 13BN/Mcwi partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 7 116.05 mmHg 5.46 14.44 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 15044 381
SS-Chr 13BN/Mcwi blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 7 7.45 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14598 381
SS-Chr 13BN/Mcwi mean arterial blood pressure controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data arterial blood pressure trait female 80.0 days-99.0 days 17 143.21 mmHg 1.44 5.93 vascular fluid filled catheter Moms were fed Teklad, pups used in studies were fed Dyets 52851 482
SS-Chr 13BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data renin activity male 80.0 days-99.0 days 17 0.43 ng/ml/h 0.09 0.35 radioimmunoassay Moms were fed Teklad, pups used in studies were fed Dyets 52461 482
SS-Chr 13BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine albumin amount female 80.0 days-99.0 days 20 5.13 mg/d 0.94 4.22 radioimmunoassay Moms were fed Teklad, pups used in studies were fed Dyets 52602 482
SS-Chr 13BN/Mcwi percent change in tidal volume controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 9 155.43 % 6.54 19.61 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 54093 381
SS-Chr 13BN/Mcwi percent change in respiration rate controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 9 169.15 % 13.11 39.34 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 54227 381
SS-Chr 13BN/Mcwi mean arterial blood pressure controlled sodium content diet (8 %) (between 16 and 19 days) Moreno et al. Physiol Genomics 2007 Oct 22;31(2):228-35. Epub 2007 Jun 12. arterial blood pressure trait male 86.0 days-89.0 days 12 142.0 mmHg 1.3 4.5 vascular fluid filled catheter left femoral artery 14400 on 3 consecutive days 5404 15
SS-Chr 13BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 10 %change=VE during 2-3 min hypoxia/control during standard conditions 158.2 % 14.02 44.32 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 13687 381
SS-Chr 13BN/Mcwi absolute change in mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 7 19.8 mmHg 2.02 5.35 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 20726 381
SS-Chr 13BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 9 120.11 % 6.77 20.3 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 53900 381
SS-Chr 13BN/Mcwi absolute change in partial pressure of blood carbon dioxide resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 10 -2.47 mmHg 0.67 2.12 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 20077 381
SS-Chr 13BN/Mcwi body temperature resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 10 38.4 degrees C 0.16 0.52 digital rectal thermometry Moms and pups used in studies were fed Teklad 17637 381
SS-Chr 13BN/Mcwi respiration rate controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 9 164.19 breaths/min 4.46 13.38 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 16923 381
SS-Chr 13BN/Mcwi respiration rate control condition PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 9 102.02 breaths/min 5.84 17.52 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 18422 381
SS-Chr 13BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77.0 days-91.0 days 12 81.75 mg/dl 2.57 8.9 standard blood chemistry panel Moms and pups used in studies were fed Teklad 37104 401
SS-Chr 13BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77.0 days-91.0 days 11 87.55 mg/dl 2.44 8.1 standard blood chemistry panel Moms and pups used in studies were fed Teklad 37109 401
SS-Chr 13BN/Mcwi percent change in ventilation controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 10 %change=VE during7-9 min hypercapnia/control during standard conditions 151.29 % 14.46 45.73 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 18550 381
SS-Chr 13BN/Mcwi percent change in ventilation controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 9 %change=VE during 2-3 min hypercapnia/control during standard conditions 290.72 % 5.58 16.74 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 19223 381
SS-Chr 13BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 8 54.83 mmHg 1.79 5.06 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 20497 381
SS-Chr 13BN/Mcwi heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 17 218.66 beats/min 9.26 38.19 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48957 461
SS-Chr 13BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass male 49.0 days-63.0 days 19 190.9 g 6.8 29.7 whole body digital scale Moms and pups used in studies were fed Teklad 49552 461
SS-Chr 13BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49.0 days-63.0 days 19 13.36 % 3.62 15.79 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 49710 461
SS-Chr 13BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49.0 days-63.0 days 19 46.05 mmHg 3.66 15.94 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 50009 461
SS-Chr 13BN/Mcwi time to onset of heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49.0 days-63.0 days 10 964.6 s 33.28 105.25 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 50126 461
SS-Chr 13BN/Mcwi blood neutrophil count control condition (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77.0 days-91.0 days 12 0.48 x 1000 cells/ul 0.04 0.14 automated blood cell counting method Moms and pups used in studies were fed Teklad 38930 401
SS-Chr 13BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount female 77.0 days-91.0 days 12 4.18 g/dl 0.03 0.11 standard blood chemistry panel Moms and pups used in studies were fed Teklad 42240 401
SS-Chr 13BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount female 77.0 days-91.0 days 12 110.0 mmol/l 1.24 4.29 standard blood chemistry panel Moms and pups used in studies were fed Teklad 39124 401
SS-Chr 13BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77.0 days-91.0 days 12 20.01 pg 0.19 0.65 automated blood cell counting method Moms and pups used in studies were fed Teklad 42552 401
SS-Chr 13BN/Mcwi plasma creatinine level control condition (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77.0 days-91.0 days 11 0.2 mg/dl 0.02 0.06 automated plasma creatinine analysis Moms and pups used in studies were fed Teklad 42689 401
SS-Chr 13BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77.0 days-91.0 days 11 0.3 mg/dl 0.01 0.04 automated plasma creatinine analysis Moms and pups used in studies were fed Teklad 39588 401
SS-Chr 13BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77.0 days-91.0 days 11 0.31 x 1000 cells/ul 0.08 0.27 automated blood cell counting method Moms and pups used in studies were fed Teklad 39686 401
SS-Chr 13BN/Mcwi serum bicarbonate level control condition (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77.0 days-91.0 days 11 22.18 mmol/l 0.69 2.27 standard blood chemistry panel Moms and pups used in studies were fed Teklad 43033 401
SS-Chr 13BN/Mcwi percent change in tidal volume controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 9 167.26 % 5.73 17.19 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 54440 381
SS-Chr 13BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass male 77.0 days-91.0 days 11 255.3 g 5.7 18.9 whole body digital scale Moms and pups used in studies were fed Teklad 59074 526
SS-Chr 13BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77.0 days-91.0 days 12 43.25 U/l 1.55 5.36 standard blood chemistry panel Moms and pups used in studies were fed Teklad 40721 401
SS-Chr 13BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77.0 days-91.0 days 11 1.85 mg/kg 0.4 1.32 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 59207 526
SS-Chr 13BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77.0 days-91.0 days 11 57.16 % 1.1 3.64 microhematocrit tube assay with visual assessment Moms and pups used in studies were fed Teklad 59269 526
SS-Chr 13BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77.0 days-91.0 days 11 0.05 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung Moms and pups used in studies were fed Teklad 59392 526
SS-Chr 13BN/Mcwi lung dry weight to body weight ratio control condition (for 14 days) PhysGen Lung data lung mass female 77.0 days-91.0 days 12 1.02 g/kg 0.02 0.05 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 59488 526
SS-Chr 13BN/Mcwi lung dry weight to body weight ratio control condition (for 14 days) PhysGen Lung data lung mass male 77.0 days-91.0 days 11 0.84 g/kg 0.02 0.07 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 59497 526
SS-Chr 13BN/Mcwi serum alanine aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77.0 days-91.0 days 12 40.42 U/l 2.02 6.99 standard blood chemistry panel Moms and pups used in studies were fed Teklad 37741 401
SS-Chr 13BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77.0 days-91.0 days 12 17.91 g/dl 0.28 0.96 automated blood cell counting method Moms and pups used in studies were fed Teklad 37975 401
SS-Chr 13BN/Mcwi serum glucose level control condition (for 14 days) PhysGen Biochemistry data blood glucose amount male 77.0 days-91.0 days 11 161.18 mg/dl 5.07 16.82 standard blood chemistry panel Moms and pups used in studies were fed Teklad 41237 401
SS-Chr 13BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77.0 days-91.0 days 12 25.25 mmol/l 1.91 6.62 standard blood chemistry panel Moms and pups used in studies were fed Teklad 38268 401
SS-Chr 13BN/Mcwi serum total cholesterol level control condition (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77.0 days-91.0 days 12 96.75 mg/dl 1.53 5.29 standard blood chemistry panel Moms and pups used in studies were fed Teklad 38467 401
SS-Chr 13BN/Mcwi serum total cholesterol level control condition (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77.0 days-91.0 days 11 81.09 mg/dl 2.11 7.01 standard blood chemistry panel Moms and pups used in studies were fed Teklad 38476 401
SS-Chr 13BN/Mcwi red blood cell count control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77.0 days-91.0 days 11 7.53 x 10E6 cells/ul 0.09 0.29 automated blood cell counting method Moms and pups used in studies were fed Teklad 42012 401
SS-Chr 13BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 17 44.55 mmHg 5.3 21.87 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 46429 461
SS-Chr 13BN/Mcwi time to peak heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 17 1162.88 s 56.55 233.16 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 46560 461
SS-Chr 13BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49.0 days-63.0 days 19 0.27 IU/g 0.04 0.16 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 47477 461
SS-Chr 13BN/Mcwi hematocrit control condition (for 14 days) PhysGen Lung data erythrocyte quantity male 77.0 days-91.0 days 11 43.25 % 0.47 1.57 microhematocrit tube assay with visual assessment Moms and pups used in studies were fed Teklad 57530 526
SS-Chr 13BN/Mcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 9 26.06 ml/min 1.54 4.63 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 16159 381
SS-Chr 13BN/Mcwi absolute change in partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 10 4.36 mmHg 2.46 7.77 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 16280 381
SS-Chr 13BN/Mcwi body weight controlled sodium content diet (4 %) (for 21 days) PhysGen Vascular data body mass female 70.0 days-84.0 days 16 215.8 g 4.0 15.8 whole body digital scale Moms and pups used in studies were fed Teklad 55205 522
SS-Chr 13BN/Mcwi tidal volume controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 9 0.45 ml 0.03 0.09 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 16480 381
SS-Chr 13BN/Mcwi body weight control condition (for 21 days) PhysGen Vascular data body mass male 70.0 days-84.0 days 9 260.5 g 24.3 73.0 whole body digital scale Moms and pups used in studies were fed Teklad 55448 522
SS-Chr 13BN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 9 -6.57 null 0.08 0.24 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 55659 522
SS-Chr 13BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70.0 days-84.0 days 10 -7.97 null 0.09 0.28 wire myography using a Digi-Med tissue force analysis system with force transducer EC50 value is moles/liter Moms and pups used in studies were fed Teklad 56139 522
SS-Chr 13BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77.0 days-91.0 days 12 0.04 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung Moms and pups used in studies were fed Teklad 58496 526
SS-Chr 13BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 10 0.43 null 0.03 0.08 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 59815 526
SS-Chr 13BN/Mcwi calculated pulmonary vascular resistance normalized to body weight Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 11 0.11 mmHg x min x kg x ml-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung Moms and pups used in studies were fed Teklad 59922 526
SS-Chr 13BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 10 14.35 ml/min/kg 0.86 2.7 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 60028 526
SS-Chr 13BN/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 9 52.0 % 6.28 18.83 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 57179 522
SS-Chr 13BN/Mcwi left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 17 99.59 mmHg 5.08 20.96 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 44827 461
SS-Chr 13BN/Mcwi percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49.0 days-63.0 days 17 post-ischemic value/pre-ischemic value x 100% 56.56 % 3.07 12.66 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 46078 461
SS-Chr 13BN/Mcwi heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 10 232.05 beats/min 6.75 21.36 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48204 461
SS-Chr 13BN/Mcwi percent change in left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 7 post-ischemic value/pre-ischemic value x 100% 42.87 % 4.71 12.45 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 46326 461
SS-Chr 13BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 18 58.08 mmHg 4.6 19.52 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 45277 461
SS-Chr 13BN/Mcwi body weight common peroneal nerve direct electrical stimulation (3 V) (for 8 hours) Stodola TJ, et al., Physiol Genomics. 2011 Jul 14;43(13):808-17. doi: 10.1152/physiolgenomics.00171.2010. Epub 2011 Apr 26. body mass male 56.0 days-70.0 days 15 316.4 g 6.8 26.34 body weighing method 0.0 99006 2198
SS-Chr 13BN/Mcwi tibialis anterior muscle weight to body weight ratio common peroneal nerve direct electrical stimulation (3 V) (for 8 hours) Stodola TJ, et al., Physiol Genomics. 2011 Jul 14;43(13):808-17. doi: 10.1152/physiolgenomics.00171.2010. Epub 2011 Apr 26. skeletal muscle mass male 56.0 days-70.0 days 15 TA/BW 1.85 mg/g 0.04 0.15 ex vivo method 0.0 TA or EDL muscle weight body weight ratio 99036 2198