Phenominer Database Results (462 results)

 
 
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Strain Phenotype Conditions Study Experiment Name Sex Age # of Animals Formula Value Units SEM SD Method Method Duration Post Insult Time Value Method Notes Clinical Measurement Notes Experiment Notes Record ID Study ID
LE/BluGill tidal volume controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 12 0.46 ml 0.02 0.07 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 15533 381
LE/BluGill partial pressure of blood oxygen resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 9 99.29 mmHg 4.51 13.53 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 15564 381
LE/BluGill body temperature resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 11 37.28 degrees C 0.19 0.62 digital rectal thermometry Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 15579 381
LE/BluGill urine sodium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine sodium amount male 80.0 days-99.0 days 7 23.29 mEq/d 1.27 3.37 flame atomic emission spectrometry Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 52828 482
LE/BluGill mean arterial blood pressure controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data arterial blood pressure trait female 80.0 days-99.0 days 9 113.88 mmHg 4.03 12.09 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 52241 482
LE/BluGill heart rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data heart pumping trait female 80.0 days-99.0 days 9 429.78 beats/min 17.94 53.83 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 52629 482
LE/BluGill percent change in respiration rate controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 9 157.57 % 9.37 28.1 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 54174 381
LE/BluGill percent change in tidal volume controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 9 133.87 % 5.49 16.46 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 54185 381
LE/BluGill partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 9 105.38 mmHg 3.63 10.89 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 14301 381
LE/BluGill percent change in ventilation controlled sodium content diet (0 %) then controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 10 %change=VE during7-9 min hypoxia/control during standard conditions 139.08 % 9.71 30.72 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17338 381
LE/BluGill tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 10 0.31 ml 0.02 0.05 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 14013 381
LE/BluGill minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 10 50.6 ml/min 3.49 11.03 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19721 381
LE/BluGill percent change in respiration rate controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 12 154.13 % 8.64 29.92 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 53859 381
LE/BluGill body temperature control condition PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 13 36.97 degrees C 0.29 1.06 digital rectal thermometry Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19950 381
LE/BluGill mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 8 106.85 mmHg 1.94 5.5 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 20135 381
LE/BluGill heart rate control condition PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 9 362.96 beats/min 12.38 37.13 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19547 381
LE/BluGill minute ventilation controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 12 78.88 ml/min 3.34 11.56 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19594 381
LE/BluGill minute ventilation controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 9 68.46 ml/min 4.76 14.29 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17584 381
LE/BluGill body temperature control condition PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 9 37.72 degrees C 0.21 0.64 digital rectal thermometry Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17785 381
LE/BluGill body temperature control condition PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 12 36.87 degrees C 0.19 0.64 digital rectal thermometry Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17789 381
LE/BluGill mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 7 117.19 mmHg 3.31 8.75 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18772 381
LE/BluGill body temperature resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 10 37.85 degrees C 0.15 0.48 digital rectal thermometry Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18805 381
LE/BluGill blood pH resting on treadmill (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 9 7.47 null 0.0 0.01 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 18994 381
LE/BluGill mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77.0 days-91.0 days 9 60.34 fl 0.54 1.63 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36290 401
LE/BluGill hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77.0 days-91.0 days 9 58.07 % 0.79 2.37 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36349 401
LE/BluGill mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77.0 days-91.0 days 9 19.26 pg 0.15 0.46 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36359 401
LE/BluGill tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 10 0.31 ml 0.02 0.08 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19041 381
LE/BluGill tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 13 0.35 ml 0.02 0.07 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19045 381
LE/BluGill serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77.0 days-91.0 days 10 7.99 mg/dl 0.32 1.01 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36724 401
LE/BluGill blood pH control condition PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 8 7.46 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19326 381
LE/BluGill heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49.0 days-63.0 days 9 17.51 % 7.34 22.01 digital scale post excision weight measurement Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49039 461
LE/BluGill time to onset of heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49.0 days-63.0 days 11 1104.0 s 42.84 142.07 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49485 461
LE/BluGill heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49.0 days-63.0 days 11 31.45 mmHg 4.09 13.56 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49593 461
LE/BluGill percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 6 post-ischemic value/pre-ischemic value x 100% 87.82 % 3.02 7.39 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49657 461
LE/BluGill percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 7 post-ischemic value/pre-ischemic value x 100% 78.17 % 3.71 9.83 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49662 461
LE/BluGill heart weight to body weight ratio control condition PhysGen Cardiac data heart mass male 49.0 days-63.0 days 10 3.56 g/kg 0.16 0.5 digital scale post excision weight measurement Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49674 461
LE/BluGill left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 6 129.84 mmHg 4.01 9.83 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49806 461
LE/BluGill heart left ventricle infarction weight to total heart left ventricle weight ratio controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49.0 days-63.0 days 11 12.13 % 3.46 11.47 digital scale post excision weight measurement Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49860 461
LE/BluGill serum phosphate level control condition (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77.0 days-91.0 days 14 7.56 mg/dl 0.38 1.41 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38839 401
LE/BluGill serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77.0 days-91.0 days 9 5.22 mmol/l 0.19 0.58 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 39101 401
LE/BluGill plasma anion gap control condition (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77.0 days-91.0 days 14 23.5 mmol/l 0.33 1.22 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 42361 401
LE/BluGill serum sodium level control condition (for 14 days) PhysGen Biochemistry data blood sodium amount female 77.0 days-91.0 days 14 145.86 mmol/l 0.47 1.75 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 39342 401
LE/BluGill plasma creatinine level control condition (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77.0 days-91.0 days 11 0.24 mg/dl 0.03 0.09 automated plasma creatinine analysis Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 39560 401
LE/BluGill total white blood cell count control condition (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77.0 days-91.0 days 11 4.61 x 1000 cells/ul 0.3 1.0 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 42862 401
LE/BluGill percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 10 149.13 % 14.1 44.58 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 54524 381
LE/BluGill percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 13 143.83 % 4.59 16.54 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 54529 381
LE/BluGill serum globulin level control condition (for 14 days) PhysGen Biochemistry data blood globulin amount female 77.0 days-91.0 days 14 2.34 g/dl 0.04 0.16 standard blood chemistry panel replaced obsolete serum globulin level term, 1/19/2016 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 39981 401
LE/BluGill calculated pulmonary vascular resistance normalized to body weight Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 14 0.14 mmHg x min x kg x ml-1 0.01 0.04 fluid-filled catheter with pressure transducer in isolated perfused lung Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 59042 526
LE/BluGill serum glucose level control condition (for 14 days) PhysGen Biochemistry data blood glucose amount female 77.0 days-91.0 days 14 153.5 mg/dl 3.11 11.65 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 40490 401
LE/BluGill serum potassium level control condition (for 14 days) PhysGen Biochemistry data blood potassium amount female 77.0 days-91.0 days 14 4.76 mmol/l 0.09 0.33 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 40650 401
LE/BluGill serum potassium level control condition (for 14 days) PhysGen Biochemistry data blood potassium amount male 77.0 days-91.0 days 10 5.14 mmol/l 0.12 0.39 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 40654 401
LE/BluGill plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77.0 days-91.0 days 9 0.28 mg/dl 0.01 0.04 automated plasma creatinine analysis Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 40802 401
LE/BluGill serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77.0 days-91.0 days 9 0.1 mg/dl 0.0 0.0 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 37546 401
LE/BluGill mean corpuscular volume control condition (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77.0 days-91.0 days 11 55.85 fl 0.46 1.54 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 37796 401
LE/BluGill serum calcium level control condition (for 14 days) PhysGen Biochemistry data blood calcium amount male 77.0 days-91.0 days 11 10.03 mg/dl 0.21 0.71 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 37935 401
LE/BluGill red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77.0 days-91.0 days 10 10.02 x 10E6 cells/ul 0.23 0.74 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38158 401
LE/BluGill serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77.0 days-91.0 days 10 141.8 mmol/l 0.51 1.62 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38245 401
LE/BluGill concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70.0 days-84.0 days 15 0.0 umol/l 0.0 0.0 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57430 522
LE/BluGill methylene blue metabolism-surface area product after auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 14 10.88 ml/min/kg 1.17 4.39 isolated perfused lung vascular effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57454 526
LE/BluGill lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass male 77.0 days-91.0 days 15 0.97 g/kg 0.04 0.16 digital scale post excision weight measurement Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57582 526
LE/BluGill acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 14 62.79 % 2.82 10.56 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 55387 522
LE/BluGill calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 13 0.16 mmHg x min x kg x ml-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57686 526
LE/BluGill maximum contractile force per wet weight of aorta potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait female 70.0 days-84.0 days 14 1.93 g/mg 0.1 0.39 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 55862 522
LE/BluGill methylene blue metabolism-surface area product without auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 13 11.53 ml/min/kg 0.99 3.57 isolated perfused lung vascular effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 58313 526
LE/BluGill heart right ventricle weight to left ventricle weight ratio control condition (for 14 days) PhysGen Lung data heart right ventricle mass female 77.0 days-91.0 days 10 0.25 null 0.01 0.03 digital scale post excision weight measurement Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 58445 526
LE/BluGill logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 14 -7.41 null 0.09 0.33 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 54748 522
LE/BluGill methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 14 0.42 null 0.01 0.05 isolated perfused lung vascular effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 58581 526
LE/BluGill body weight control condition (for 21 days) PhysGen Vascular data body mass male 70.0 days-84.0 days 12 343.4 g 9.4 32.7 whole body digital scale Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 54878 522
LE/BluGill methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 14 13.93 ml/min/kg 0.89 3.35 isolated perfused lung vascular effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 58843 526
LE/BluGill methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 13 12.13 ml/min/kg 0.52 1.88 isolated perfused lung vascular effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 59865 526
LE/BluGill logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 11 -7.36 null 0.02 0.06 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56781 522
LE/BluGill body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass female 77.0 days-91.0 days 14 203.5 g 9.5 35.6 whole body digital scale Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 60101 526
LE/BluGill FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 13 40.53 ml/min/kg 2.35 8.47 isolated perfused lung vascular effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 60133 526
LE/BluGill maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait male 70.0 days-84.0 days 14 1.71 g/mg 0.13 0.47 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56870 522
LE/BluGill concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70.0 days-84.0 days 13 0.02 umol/l 0.01 0.02 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57002 522
LE/BluGill arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49.0 days-63.0 days 11 5.08 ml/min/g 0.37 1.23 isolated perfused heart effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45895 461
LE/BluGill left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 9 43.49 mmHg 6.61 19.82 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45942 461
LE/BluGill percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49.0 days-63.0 days 8 post-ischemic value/pre-ischemic value x 100% 65.87 % 8.9 25.16 isolated perfused heart effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47893 461
LE/BluGill arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49.0 days-63.0 days 11 8.64 ml/min/g 0.64 2.12 isolated perfused heart effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 46156 461
LE/BluGill time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49.0 days-63.0 days 11 983.73 s 101.76 337.49 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 48124 461
LE/BluGill heart wet weight control condition PhysGen Cardiac data heart mass female 49.0 days-63.0 days 11 0.9 g 0.03 0.09 digital scale post excision weight measurement Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 48147 461
LE/BluGill heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 11 240.18 beats/min 9.74 32.29 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 48176 461
LE/BluGill heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 9 257.77 beats/min 8.55 25.65 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 48181 461
LE/BluGill left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 7 116.24 mmHg 1.67 4.41 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45025 461
LE/BluGill heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49.0 days-63.0 days 11 0.96 g 0.1 0.34 digital scale post excision weight measurement Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45034 461
LE/BluGill percent change in left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 11 post-ischemic value/pre-ischemic value x 100% 60.34 % 5.53 18.36 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45046 461
LE/BluGill time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 9 1330.89 s 55.91 167.73 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45112 461
LE/BluGill heart contraction pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49.0 days-63.0 days 11 49.73 mmHg 4.7 15.58 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47385 461
LE/BluGill left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 9 48.55 mmHg 7.98 23.94 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47402 461
LE/BluGill left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 9 50.81 mmHg 5.06 15.19 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47414 461
LE/BluGill heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49.0 days-63.0 days 9 0.37 IU/g 0.1 0.3 isolated perfused heart effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45241 461
LE/BluGill partial pressure of blood carbon dioxide (Pco2) resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 9 28.04 mmHg 0.94 2.82 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 15633 381
LE/BluGill mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 9 103.47 mmHg 6.93 20.78 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 15798 381
LE/BluGill mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 9 109.91 mmHg 3.14 9.41 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 15802 381
LE/BluGill partial pressure of blood carbon dioxide (Pco2) control condition PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 8 32.62 mmHg 0.77 2.17 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 15365 381
LE/BluGill percent change in ventilation controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 12 %change=VE during 2-3 min hypercapnia/control during standard conditions 199.77 % 11.81 40.91 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 14407 381
LE/BluGill percent change in ventilation controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 9 %change=VE during7-9 min hypercapnia/control during standard conditions 209.36 % 16.11 48.34 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 15213 381
LE/BluGill creatinine clearance controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data glomerular filtration trait male 80.0 days-99.0 days 6 2.56 ml/min 0.2 0.5 urine creatinine analysis Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 52291 482
LE/BluGill urine total protein excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data total urine protein amount male 80.0 days-99.0 days 7 39.37 mg/d 5.21 13.77 automated urine total protein analysis Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 52730 482
LE/BluGill percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 13 93.56 % 3.26 11.74 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 54201 381
LE/BluGill mean arterial blood pressure controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 7 112.62 mmHg 3.5 9.26 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 13454 381
LE/BluGill body temperature controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 9 37.34 degrees C 0.12 0.36 digital rectal thermometry Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 14178 381
LE/BluGill percent change in ventilation controlled sodium content diet (0 %) then controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 13 %change=VE during7-9 min hypoxia/control during standard conditions 144.14 % 5.01 18.07 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17342 381
LE/BluGill mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 9 94.47 mmHg 7.0 21.0 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 13881 381
LE/BluGill blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 7 7.48 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14048 381
LE/BluGill absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 6 -5.93 mmHg 0.61 1.49 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 20989 381
LE/BluGill body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 10 37.85 degrees C 0.11 0.35 digital rectal thermometry Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19995 381
LE/BluGill absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 6 -48.53 mmHg 1.05 2.57 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 20695 381
LE/BluGill partial pressure of blood carbon dioxide (Pco2) resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 9 32.09 mmHg 0.72 2.17 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19692 381
LE/BluGill respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 13 168.56 breaths/min 10.44 37.64 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17565 381
LE/BluGill minute ventilation controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 12 79.57 ml/min 6.11 21.15 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17588 381
LE/BluGill respiration rate controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 9 178.17 breaths/min 13.28 39.83 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17960 381
LE/BluGill heart rate controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 7 321.43 beats/min 4.85 12.84 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18084 381
LE/BluGill partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 6 50.03 mmHg 1.94 4.75 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17015 381
LE/BluGill mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 7 102.7 mmHg 3.35 8.86 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18768 381
LE/BluGill blood pH resting on treadmill (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 9 7.46 null 0.01 0.04 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 18990 381
LE/BluGill serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77.0 days-91.0 days 9 6.39 g/dl 0.05 0.15 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36266 401
LE/BluGill serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77.0 days-91.0 days 10 6.62 g/dl 0.11 0.35 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36270 401
LE/BluGill mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77.0 days-91.0 days 10 59.45 fl 0.72 2.27 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36294 401
LE/BluGill blood neutrophil count control condition (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77.0 days-91.0 days 13 0.54 x 1000 cells/ul 0.04 0.15 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36302 401
LE/BluGill serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77.0 days-91.0 days 9 7.68 mg/dl 0.5 1.5 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36720 401
LE/BluGill heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49.0 days-63.0 days 11 7.35 % 3.79 12.56 digital scale post excision weight measurement Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49034 461
LE/BluGill left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 11 100.76 mmHg 6.27 20.8 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49278 461
LE/BluGill left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 9 103.04 mmHg 6.72 20.17 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49283 461
LE/BluGill left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 9 99.53 mmHg 3.6 10.8 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49791 461
LE/BluGill body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass female 49.0 days-63.0 days 11 152.2 g 7.2 23.8 whole body digital scale Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50084 461
LE/BluGill absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 13 0.56 degrees C 0.23 0.84 digital rectal thermometry Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19163 381
LE/BluGill hematocrit control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77.0 days-91.0 days 13 45.84 % 0.49 1.76 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38867 401
LE/BluGill serum total bilirubin level control condition (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77.0 days-91.0 days 11 0.1 mg/dl 0.0 0.0 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 42184 401
LE/BluGill mean corpuscular hemoglobin concentration control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77.0 days-91.0 days 13 32.02 g/dl 0.16 0.58 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 42213 401
LE/BluGill serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount female 77.0 days-91.0 days 9 4.97 mmol/l 0.1 0.3 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 39097 401
LE/BluGill serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77.0 days-91.0 days 10 337.9 U/l 21.04 66.53 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 42355 401
LE/BluGill plasma anion gap control condition (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77.0 days-91.0 days 11 23.73 mmol/l 0.51 1.68 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 42365 401
LE/BluGill serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount female 77.0 days-91.0 days 9 9.34 mg/dl 0.16 0.49 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 42525 401
LE/BluGill total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77.0 days-91.0 days 10 4.39 x 1000 cells/ul 0.22 0.7 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 39498 401
LE/BluGill total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77.0 days-91.0 days 9 4.13 x 1000 cells/ul 0.48 1.44 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 39494 401
LE/BluGill mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77.0 days-91.0 days 10 32.19 g/dl 0.09 0.28 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 42738 401
LE/BluGill blood monocyte count control condition (for 14 days) PhysGen Biochemistry data monocyte quantity female 77.0 days-91.0 days 13 0.14 x 1000 cells/ul 0.02 0.08 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 43083 401
LE/BluGill percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 13 157.01 % 9.22 33.24 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 53605 381
LE/BluGill calculated pulmonary vascular resistance normalized to body weight Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 13 0.13 mmHg x min x kg x ml-1 0.01 0.04 fluid-filled catheter with pressure transducer in isolated perfused lung Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 59046 526
LE/BluGill blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77.0 days-91.0 days 10 0.03 x 1000 cells/ul 0.01 0.03 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 40510 401
LE/BluGill serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount female 77.0 days-91.0 days 9 4.28 g/dl 0.03 0.08 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 41136 401
LE/BluGill serum total cholesterol level control condition (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77.0 days-91.0 days 11 114.73 mg/dl 4.41 14.64 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 37914 401
LE/BluGill blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77.0 days-91.0 days 9 3.33 x 1000 cells/ul 0.43 1.3 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38219 401
LE/BluGill serum aspartate aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77.0 days-91.0 days 10 138.6 U/l 5.67 17.95 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 41619 401
LE/BluGill blood eosinophil count control condition (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77.0 days-91.0 days 13 0.02 x 1000 cells/ul 0.01 0.03 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38349 401
LE/BluGill blood eosinophil count control condition (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77.0 days-91.0 days 11 0.04 x 1000 cells/ul 0.01 0.04 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38353 401
LE/BluGill serum alanine aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77.0 days-91.0 days 10 76.5 U/l 5.26 16.63 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38622 401
LE/BluGill heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 11 208.44 beats/min 17.39 57.69 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 46505 461
LE/BluGill percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 7 post-ischemic value/pre-ischemic value x 100% 47.41 % 8.89 23.51 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47531 461
LE/BluGill percent change in heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 9 post-ischemic value/pre-ischemic value x 100% 95.7 % 9.8 29.41 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47551 461
LE/BluGill FAPGG metabolism-surface area product FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 14 48.2 ml/min/kg 5.35 20.02 isolated perfused lung vascular effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57464 526
LE/BluGill heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 9 370.38 beats/min 12.06 36.18 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 16127 381
LE/BluGill fractional change in blood vessel diameter per unit change in intravascular pressure Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77.0 days-91.0 days 14 0.04 mmHg-1 0.01 0.03 fluid-filled catheter with pressure transducer in isolated perfused lung Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57696 526
LE/BluGill body weight control condition (for 14 days) PhysGen Lung data body mass male 77.0 days-91.0 days 17 340.4 g 11.5 47.4 whole body digital scale Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57710 526
LE/BluGill dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77.0 days-91.0 days 12 6.02 mg/kg 1.82 6.29 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57768 526
LE/BluGill partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 8 26.99 mmHg 0.76 2.14 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 16368 381
LE/BluGill absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 7 0.04 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 16670 381
LE/BluGill absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 6 0.04 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 16674 381
LE/BluGill fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77.0 days-91.0 days 13 0.03 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 58087 526
LE/BluGill methylene blue metabolism-surface area product without auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 14 14.81 ml/min/kg 1.73 6.46 isolated perfused lung vascular effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 58309 526
LE/BluGill heart right ventricle weight to left ventricle weight ratio control condition (for 14 days) PhysGen Lung data heart right ventricle mass male 77.0 days-91.0 days 12 0.24 null 0.01 0.03 digital scale post excision weight measurement Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 58449 526
LE/BluGill body weight controlled sodium content diet (4 %) (for 21 days) PhysGen Vascular data body mass male 70.0 days-84.0 days 14 393.6 g 8.2 30.7 whole body digital scale Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56077 522
LE/BluGill hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity female 77.0 days-91.0 days 9 58.07 % 0.79 2.37 microhematocrit tube assay with visual assessment Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 58587 526
LE/BluGill lung dry weight to body weight ratio control condition (for 14 days) PhysGen Lung data lung mass male 77.0 days-91.0 days 17 0.88 g/kg 0.04 0.16 digital scale post excision weight measurement Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 58833 526
LE/BluGill logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 14 -8.28 null 0.06 0.24 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 55120 522
LE/BluGill logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 14 -8.48 null 0.06 0.24 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 55116 522
LE/BluGill heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass female 77.0 days-91.0 days 14 0.41 null 0.02 0.06 digital scale post excision weight measurement Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 59971 526
LE/BluGill acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 14 63.93 % 5.31 19.87 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56752 522
LE/BluGill logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70.0 days-84.0 days 11 -7.87 null 0.08 0.26 wire myography using a Digi-Med tissue force analysis system with force transducer EC50 value is moles/liter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56824 522
LE/BluGill hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 14 43.07 % 2.87 10.74 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56830 522
LE/BluGill dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77.0 days-91.0 days 15 2.81 mg/kg 0.74 2.87 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 60115 526
LE/BluGill sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 13 99.54 % 0.33 1.2 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57121 522
LE/BluGill left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 6 124.22 mmHg 3.94 9.65 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47670 461
LE/BluGill percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49.0 days-63.0 days 11 post-ischemic value/pre-ischemic value x 100% 60.86 % 5.74 19.04 isolated perfused heart effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45858 461
LE/BluGill arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49.0 days-63.0 days 9 5.46 ml/min/g 0.44 1.32 isolated perfused heart effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45900 461
LE/BluGill left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 7 110.79 mmHg 1.56 4.12 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 46050 461
LE/BluGill percent change in left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 9 post-ischemic value/pre-ischemic value x 100% 89.64 % 4.25 12.75 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 46173 461
LE/BluGill arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49.0 days-63.0 days 10 7.44 ml/min/g 0.97 3.06 isolated perfused heart effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 46180 461
LE/BluGill left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 9 5.51 mmHg 0.2 0.61 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 48167 461
LE/BluGill arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49.0 days-63.0 days 8 11.25 ml/min/g 0.8 2.25 isolated perfused heart effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45092 461
LE/BluGill time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 11 1356.45 s 56.24 186.52 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45107 461
LE/BluGill heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49.0 days-63.0 days 11 0.3 IU/g 0.03 0.11 isolated perfused heart effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45236 461
LE/BluGill heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 9 248.1 beats/min 28.47 85.41 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45363 461
LE/BluGill minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 9 33.25 ml/min 1.81 5.42 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 15493 381
LE/BluGill minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 12 41.14 ml/min 2.95 10.21 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 15497 381
LE/BluGill partial pressure of blood oxygen resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 9 93.76 mmHg 5.38 16.15 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 15568 381
LE/BluGill absolute change in blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 7 0.03 null 0.01 0.02 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 15604 381
LE/BluGill percent change in ventilation controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 9 %change=VE during 2-3 min hypercapnia/control during standard conditions 221.53 % 20.27 60.8 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 14403 381
LE/BluGill plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount female 80.0 days-99.0 days 9 0.33 mg/dl 0.02 0.07 radioimmunoassay Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 52239 482
LE/BluGill plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data renin activity male 80.0 days-99.0 days 6 4.74 ng/ml/h 1.34 3.27 radioimmunoassay Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 52579 482
LE/BluGill percent change in respiration rate controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 12 156.4 % 15.42 53.4 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 54179 381
LE/BluGill percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 10 98.04 % 8.11 25.64 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 54196 381
LE/BluGill body temperature controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 12 36.98 degrees C 0.08 0.28 digital rectal thermometry Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 14182 381
LE/BluGill partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 7 116.5 mmHg 4.1 10.83 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 14297 381
LE/BluGill absolute change in partial pressure of blood carbon dioxide resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 7 -4.98 mmHg 0.92 2.44 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17201 381
LE/BluGill absolute change in partial pressure of blood carbon dioxide resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 8 -4.74 mmHg 0.74 2.08 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17205 381
LE/BluGill blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 9 7.5 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14052 381
LE/BluGill partial pressure of blood oxygen control condition PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 8 103.54 mmHg 2.75 7.77 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 14080 381
LE/BluGill body temperature control condition PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 10 37.75 degrees C 0.15 0.48 digital rectal thermometry Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19946 381
LE/BluGill body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 13 37.53 degrees C 0.12 0.43 digital rectal thermometry Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19999 381
LE/BluGill absolute change in mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 8 9.34 mmHg 1.42 4.02 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 20108 381
LE/BluGill mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 9 118.44 mmHg 1.42 4.25 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 20139 381
LE/BluGill minute ventilation controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 9 72.45 ml/min 5.81 17.42 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19590 381
LE/BluGill respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 10 162.35 breaths/min 6.76 21.37 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17561 381
LE/BluGill minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 13 37.83 ml/min 2.08 7.51 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17911 381
LE/BluGill heart rate control condition PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 7 428.73 beats/min 6.67 17.66 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18390 381
LE/BluGill heart rate control condition PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 7 424.13 beats/min 33.21 87.86 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18394 381
LE/BluGill minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 10 46.22 ml/min 2.52 7.97 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18967 381
LE/BluGill mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77.0 days-91.0 days 10 19.15 pg 0.26 0.81 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36363 401
LE/BluGill absolute change in body temperature resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 10 0.44 degrees C 0.25 0.79 digital rectal thermometry Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18516 381
LE/BluGill tidal volume controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 9 0.4 ml 0.01 0.04 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18523 381
LE/BluGill tidal volume controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 12 0.46 ml 0.02 0.08 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18527 381
LE/BluGill red blood cell count control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77.0 days-91.0 days 13 8.06 x 10E6 cells/ul 0.1 0.34 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36575 401
LE/BluGill percent change in ventilation controlled sodium content diet (0 %) then controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 13 %change=VE during 2-3 min hypoxia/control during standard conditions 151.33 % 5.57 20.09 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19309 381
LE/BluGill respiration rate control condition PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 9 109.15 breaths/min 5.89 17.68 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18160 381
LE/BluGill respiration rate control condition PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 12 116.64 breaths/min 6.86 23.76 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18164 381
LE/BluGill respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 10 163.97 breaths/min 7.29 23.04 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18211 381
LE/BluGill respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 13 154.11 breaths/min 4.94 17.8 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18215 381
LE/BluGill respiration rate controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 9 170.57 breaths/min 11.33 33.98 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 20180 381
LE/BluGill respiration rate controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 12 174.04 breaths/min 9.63 33.35 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 20184 381
LE/BluGill heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49.0 days-63.0 days 11 6.33 g/kg 0.73 2.43 digital scale post excision weight measurement Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49148 461
LE/BluGill heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49.0 days-63.0 days 9 4.78 g/kg 0.29 0.88 digital scale post excision weight measurement Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49152 461
LE/BluGill percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 10 post-ischemic value/pre-ischemic value x 100% 79.93 % 6.91 21.86 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49266 461
LE/BluGill percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 9 post-ischemic value/pre-ischemic value x 100% 89.79 % 5.16 15.48 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49271 461
LE/BluGill time to onset of heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49.0 days-63.0 days 9 1027.89 s 40.39 121.16 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49490 461
LE/BluGill left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 11 100.27 mmHg 6.63 22.0 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49786 461
LE/BluGill left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 7 140.09 mmHg 4.82 12.75 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49811 461
LE/BluGill heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 10 255.49 beats/min 10.11 31.97 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49976 461
LE/BluGill heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 9 254.68 beats/min 9.34 28.01 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49981 461
LE/BluGill blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77.0 days-91.0 days 10 0.75 x 1000 cells/ul 0.07 0.21 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 42375 401
LE/BluGill serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount female 77.0 days-91.0 days 9 2.11 g/dl 0.04 0.12 standard blood chemistry panel replaced obsolete serum globulin level term, 1/19/2016 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 39217 401
LE/BluGill serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77.0 days-91.0 days 10 2.31 g/dl 0.06 0.18 standard blood chemistry panel replaced obsolete serum globulin level term, 1/19/2016 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 39221 401
LE/BluGill serum sodium level control condition (for 14 days) PhysGen Biochemistry data blood sodium amount male 77.0 days-91.0 days 11 145.45 mmol/l 0.82 2.73 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 39346 401
LE/BluGill serum albumin level control condition (for 14 days) PhysGen Biochemistry data blood albumin amount male 77.0 days-91.0 days 11 4.23 g/dl 0.06 0.2 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 39356 401
LE/BluGill serum bicarbonate level control condition (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77.0 days-91.0 days 14 19.93 mmol/l 0.35 1.33 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 43073 401
LE/BluGill percent change in tidal volume controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 9 132.38 % 5.67 17.0 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 54537 381
LE/BluGill percent change in tidal volume controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 12 133.21 % 9.1 31.53 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 54542 381
LE/BluGill blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity female 77.0 days-91.0 days 9 0.19 x 1000 cells/ul 0.04 0.12 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 40694 401
LE/BluGill mean corpuscular volume control condition (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77.0 days-91.0 days 13 56.85 fl 0.31 1.13 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 37792 401
LE/BluGill serum aspartate aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77.0 days-91.0 days 13 131.54 U/l 4.78 17.25 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 41615 401
LE/BluGill blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77.0 days-91.0 days 9 18.51 g/dl 0.23 0.68 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38404 401
LE/BluGill percent change in heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 11 post-ischemic value/pre-ischemic value x 100% 85.61 % 6.93 22.99 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47546 461
LE/BluGill FAPGG metabolism-surface area product FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 13 42.1 ml/min/kg 3.55 12.8 isolated perfused lung vascular effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57468 526
LE/BluGill heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 9 376.9 beats/min 12.54 37.63 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 16131 381
LE/BluGill calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 14 0.16 mmHg x min x kg x ml-1 0.01 0.04 fluid-filled catheter with pressure transducer in isolated perfused lung Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57690 526
LE/BluGill dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77.0 days-91.0 days 12 6.24 mg/kg 1.7 5.88 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57772 526
LE/BluGill heart rate resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 11 381.2 beats/min 6.78 22.49 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 16437 381
LE/BluGill body weight control condition PhysGen Respiratory data body mass female 82.0 days-99.0 days 13 248.2 g 5.9 21.4 whole body digital scale Moms and pups used in studies were fed Dyets 16792 381
LE/BluGill maximum contractile force per wet weight of aorta potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait male 70.0 days-84.0 days 12 1.52 g/mg 0.15 0.52 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 55866 522
LE/BluGill hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 10 17.4 % 4.29 13.57 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 54646 522
LE/BluGill concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 13 0.03 10E-7mol/l 0.0 0.01 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56457 522
LE/BluGill hematocrit control condition (for 14 days) PhysGen Lung data erythrocyte quantity male 77.0 days-91.0 days 13 45.83 % 0.41 1.5 microhematocrit tube assay with visual assessment Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 59859 526
LE/BluGill hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 10 39.7 % 4.52 14.28 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56686 522
LE/BluGill hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 8 36.75 % 5.99 16.95 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56690 522
LE/BluGill concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 14 0.04 10E-7mol/l 0.01 0.02 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56767 522
LE/BluGill concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 14 0.37 E-7mole 0.05 0.17 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56801 522
LE/BluGill logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70.0 days-84.0 days 13 -7.98 null 0.11 0.39 wire myography using a Digi-Med tissue force analysis system with force transducer EC50 value is moles/liter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56820 522
LE/BluGill sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 14 100.0 % 0.0 0.0 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56856 522
LE/BluGill concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70.0 days-84.0 days 11 0.02 umol/l 0.0 0.01 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57006 522
LE/BluGill tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 10 0.29 ml 0.02 0.06 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 16037 381
LE/BluGill left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 9 59.68 mmHg 9.91 29.72 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45912 461
LE/BluGill left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 11 34.52 mmHg 4.32 14.33 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45937 461
LE/BluGill left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 9 5.77 mmHg 0.29 0.87 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 48017 461
LE/BluGill percent change in left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 11 post-ischemic value/pre-ischemic value x 100% 94.84 % 6.65 22.06 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 46168 461
LE/BluGill heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49.0 days-63.0 days 9 1.36 g 0.08 0.25 digital scale post excision weight measurement Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45039 461
LE/BluGill time to peak heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 9 1319.33 s 52.45 157.35 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45075 461
LE/BluGill left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 11 59.98 mmHg 4.67 15.49 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47397 461
LE/BluGill heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49.0 days-63.0 days 9 0.39 IU/g 0.07 0.21 isolated perfused heart effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 48388 461
LE/BluGill tidal volume controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 9 0.41 ml 0.03 0.08 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 15529 381
LE/BluGill partial pressure of blood carbon dioxide (Pco2) resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 7 25.94 mmHg 0.74 1.96 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 15629 381
LE/BluGill heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 9 469.54 beats/min 10.88 32.64 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 15791 381
LE/BluGill partial pressure of blood carbon dioxide (Pco2) control condition PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 8 32.86 mmHg 0.92 2.6 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 15369 381
LE/BluGill tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 9 0.31 ml 0.02 0.06 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 14434 381
LE/BluGill tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 12 0.36 ml 0.03 0.09 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 14438 381
LE/BluGill percent change in ventilation controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 12 %change=VE during7-9 min hypercapnia/control during standard conditions 202.28 % 17.04 59.02 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 15217 381
LE/BluGill urine sodium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine sodium amount female 80.0 days-99.0 days 9 16.09 mEq/d 2.02 6.07 flame atomic emission spectrometry Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 52827 482
LE/BluGill mean arterial blood pressure controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data arterial blood pressure trait male 80.0 days-99.0 days 7 112.29 mmHg 0.72 1.91 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 52242 482
LE/BluGill urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine albumin amount female 80.0 days-99.0 days 9 5.33 mg/d 0.83 2.48 radioimmunoassay Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 52433 482
LE/BluGill percent change in tidal volume controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 12 131.35 % 7.65 26.49 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 54190 381
LE/BluGill respiration rate control condition PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 10 116.4 breaths/min 10.02 31.7 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17327 381
LE/BluGill absolute change in body temperature controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 9 -0.38 degrees C 0.19 0.58 digital rectal thermometry Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 13870 381
LE/BluGill absolute change in heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 8 46.94 beats/min 9.36 26.47 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 14115 381
LE/BluGill absolute change in heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 9 89.97 beats/min 7.65 22.96 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 14119 381
LE/BluGill percent change in respiration rate controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 9 166.73 % 15.93 47.79 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 53854 381
LE/BluGill absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 7 -48.21 mmHg 3.33 8.82 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 20691 381
LE/BluGill heart rate control condition PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 9 426.33 beats/min 15.98 47.93 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19543 381
LE/BluGill minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 10 34.49 ml/min 2.66 8.42 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17907 381
LE/BluGill respiration rate controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 12 173.76 breaths/min 3.56 12.34 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17964 381
LE/BluGill heart rate controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 8 286.83 beats/min 27.66 78.25 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18088 381
LE/BluGill blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 8 7.48 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18095 381
LE/BluGill partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 8 55.51 mmHg 2.17 6.15 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17011 381
LE/BluGill body temperature resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 10 37.78 degrees C 0.16 0.5 digital rectal thermometry Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18809 381
LE/BluGill blood neutrophil count control condition (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77.0 days-91.0 days 11 0.9 x 1000 cells/ul 0.1 0.32 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36306 401
LE/BluGill serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount female 77.0 days-91.0 days 9 151.78 mg/dl 5.55 16.66 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36324 401
LE/BluGill serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount male 77.0 days-91.0 days 10 162.7 mg/dl 4.21 13.33 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36328 401
LE/BluGill hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77.0 days-91.0 days 10 59.49 % 0.93 2.95 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36353 401
LE/BluGill serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77.0 days-91.0 days 9 132.78 mg/dl 4.93 14.79 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36467 401
LE/BluGill serum urea nitrogen level control condition (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77.0 days-91.0 days 14 15.5 mg/dl 0.51 1.91 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 37287 401
LE/BluGill serum urea nitrogen level control condition (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77.0 days-91.0 days 11 16.45 mg/dl 0.45 1.51 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 37291 401
LE/BluGill serum total protein level control condition (for 14 days) PhysGen Biochemistry data blood total protein amount female 77.0 days-91.0 days 14 6.64 g/dl 0.07 0.25 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 37417 401
LE/BluGill serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77.0 days-91.0 days 8 141.88 U/l 13.0 36.76 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 37431 401
LE/BluGill absolute change in body temperature resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 10 0.11 degrees C 0.19 0.6 digital rectal thermometry Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18512 381
LE/BluGill serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77.0 days-91.0 days 10 113.1 mg/dl 4.72 14.93 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36471 401
LE/BluGill red blood cell count control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77.0 days-91.0 days 11 8.16 x 10E6 cells/ul 0.12 0.4 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36579 401
LE/BluGill blood pH control condition PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 8 7.45 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19322 381
LE/BluGill heart weight to body weight ratio control condition PhysGen Cardiac data heart mass female 49.0 days-63.0 days 11 4.1 g/kg 0.19 0.64 digital scale post excision weight measurement Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49670 461
LE/BluGill body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass male 49.0 days-63.0 days 9 292.8 g 21.7 65.1 whole body digital scale Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50088 461
LE/BluGill absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 10 0.1 degrees C 0.2 0.63 digital rectal thermometry Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19159 381
LE/BluGill serum total bilirubin level control condition (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77.0 days-91.0 days 14 0.11 mg/dl 0.01 0.03 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 42180 401
LE/BluGill serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77.0 days-91.0 days 9 286.67 U/l 14.7 44.1 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 42351 401
LE/BluGill blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77.0 days-91.0 days 9 0.6 x 1000 cells/ul 0.07 0.22 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 42371 401
LE/BluGill serum albumin level control condition (for 14 days) PhysGen Biochemistry data blood albumin amount female 77.0 days-91.0 days 14 4.31 g/dl 0.05 0.18 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 39352 401
LE/BluGill serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77.0 days-91.0 days 10 9.73 mg/dl 0.12 0.38 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 42529 401
LE/BluGill plasma creatinine level control condition (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77.0 days-91.0 days 14 0.27 mg/dl 0.03 0.1 automated plasma creatinine analysis Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 39556 401
LE/BluGill blood hemoglobin level control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77.0 days-91.0 days 13 14.67 g/dl 0.16 0.59 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 42744 401
LE/BluGill blood hemoglobin level control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77.0 days-91.0 days 11 14.83 g/dl 0.18 0.6 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 42748 401
LE/BluGill percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 10 105.09 % 7.82 24.74 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 53611 381
LE/BluGill blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77.0 days-91.0 days 9 0.01 x 1000 cells/ul 0.01 0.02 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 40506 401
LE/BluGill blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77.0 days-91.0 days 10 0.27 x 1000 cells/ul 0.03 0.09 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 40698 401
LE/BluGill plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77.0 days-91.0 days 10 25.5 mmol/l 0.45 1.43 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 37560 401
LE/BluGill serum chloride level control condition (for 14 days) PhysGen Biochemistry data blood chloride amount male 77.0 days-91.0 days 11 106.27 mmol/l 0.75 2.49 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 41114 401
LE/BluGill serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77.0 days-91.0 days 9 14.56 mmol/l 0.71 2.13 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 41126 401
LE/BluGill blood lymphocyte count control condition (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77.0 days-91.0 days 13 2.18 x 1000 cells/ul 0.22 0.81 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 37941 401
LE/BluGill mean corpuscular hemoglobin control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77.0 days-91.0 days 13 18.2 pg 0.07 0.26 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 41277 401
LE/BluGill mean corpuscular hemoglobin control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77.0 days-91.0 days 11 18.19 pg 0.14 0.47 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 41281 401
LE/BluGill serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount male 77.0 days-91.0 days 10 106.5 mmol/l 0.48 1.51 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38189 401
LE/BluGill blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77.0 days-91.0 days 10 3.35 x 1000 cells/ul 0.18 0.58 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38223 401
LE/BluGill serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount female 77.0 days-91.0 days 9 141.0 mmol/l 0.44 1.32 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38241 401
LE/BluGill serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77.0 days-91.0 days 9 57.44 U/l 1.84 5.53 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 41603 401
LE/BluGill serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77.0 days-91.0 days 8 75.25 U/l 6.57 18.58 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 41607 401
LE/BluGill heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 9 226.16 beats/min 9.33 28.0 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 46510 461
LE/BluGill percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 6 post-ischemic value/pre-ischemic value x 100% 61.93 % 5.89 14.44 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47526 461
LE/BluGill concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70.0 days-84.0 days 14 0.01 umol/l 0.0 0.0 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57434 522
LE/BluGill methylene blue metabolism-surface area product after auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 13 9.11 ml/min/kg 0.78 2.82 isolated perfused lung vascular effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57458 526
LE/BluGill lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass female 77.0 days-91.0 days 14 1.15 g/kg 0.04 0.14 digital scale post excision weight measurement Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57578 526
LE/BluGill logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 11 -8.48 null 0.13 0.41 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 55353 522
LE/BluGill acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 13 44.31 % 5.54 19.96 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 55391 522
LE/BluGill body weight control condition (for 14 days) PhysGen Lung data body mass female 77.0 days-91.0 days 16 260.4 g 4.1 16.3 whole body digital scale Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57706 526
LE/BluGill methylene blue to FAPGG metabolism-surface area product ratio methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 13 0.28 null 0.02 0.08 isolated perfused lung vascular effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57742 526
LE/BluGill heart rate resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 10 431.1 beats/min 5.55 17.56 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 16433 381
LE/BluGill fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77.0 days-91.0 days 14 0.04 mmHg-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 58091 526
LE/BluGill concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 14 0.52 E-7mole 0.13 0.48 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 55983 522
LE/BluGill concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 13 0.88 E-7mole 0.18 0.63 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 55987 522
LE/BluGill hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 11 27.64 % 7.74 25.67 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 54642 522
LE/BluGill logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 13 -7.17 null 0.09 0.33 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 54752 522
LE/BluGill hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 11 38.18 % 7.66 25.42 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56049 522
LE/BluGill hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 8 23.5 % 5.58 15.78 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56053 522
LE/BluGill lung dry weight to body weight ratio control condition (for 14 days) PhysGen Lung data lung mass female 77.0 days-91.0 days 16 0.94 g/kg 0.04 0.16 digital scale post excision weight measurement Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 58829 526
LE/BluGill methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 13 17.95 ml/min/kg 0.91 3.28 isolated perfused lung vascular effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 58839 526
LE/BluGill hematocrit control condition (for 14 days) PhysGen Lung data erythrocyte quantity female 77.0 days-91.0 days 13 45.84 % 0.49 1.76 microhematocrit tube assay with visual assessment Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 59855 526
LE/BluGill heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass male 77.0 days-91.0 days 15 0.41 null 0.02 0.06 digital scale post excision weight measurement Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 59975 526
LE/BluGill hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 10 37.7 % 1.82 5.76 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56712 522
LE/BluGill concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 11 0.44 E-7mole 0.02 0.06 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56805 522
LE/BluGill FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 14 33.59 ml/min/kg 2.58 9.66 isolated perfused lung vascular effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 60137 526
LE/BluGill sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 14 99.21 % 0.53 1.97 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56860 522
LE/BluGill sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 12 98.25 % 1.75 6.06 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57125 522
LE/BluGill tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 13 0.33 ml 0.02 0.07 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 16041 381
LE/BluGill percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49.0 days-63.0 days 9 post-ischemic value/pre-ischemic value x 100% 58.14 % 2.51 7.54 isolated perfused heart effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45863 461
LE/BluGill percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49.0 days-63.0 days 9 post-ischemic value/pre-ischemic value x 100% 57.9 % 5.02 15.07 isolated perfused heart effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47888 461
LE/BluGill left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 10 5.85 mmHg 0.22 0.7 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 48012 461
LE/BluGill arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49.0 days-63.0 days 9 9.29 ml/min/g 0.48 1.43 isolated perfused heart effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 46161 461
LE/BluGill body weight control condition PhysGen Cardiac data body mass female 49.0 days-63.0 days 11 221.7 g 4.8 15.9 whole body digital scale Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47164 461
LE/BluGill body weight control condition PhysGen Cardiac data body mass male 49.0 days-63.0 days 10 341.4 g 7.7 24.4 whole body digital scale Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47168 461
LE/BluGill heart wet weight control condition PhysGen Cardiac data heart mass male 49.0 days-63.0 days 10 1.21 g 0.05 0.17 digital scale post excision weight measurement Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 48152 461
LE/BluGill left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 9 5.25 mmHg 0.28 0.85 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 48162 461
LE/BluGill percent change in left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 9 post-ischemic value/pre-ischemic value x 100% 46.21 % 7.56 22.69 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45051 461
LE/BluGill arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49.0 days-63.0 days 9 13.05 ml/min/g 0.86 2.57 isolated perfused heart effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45087 461
LE/BluGill left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 11 40.29 mmHg 3.3 10.96 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47409 461
LE/BluGill heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49.0 days-63.0 days 11 0.58 IU/g 0.13 0.43 isolated perfused heart effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 48383 461
LE/BluGill absolute change in partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 7 21.99 mmHg 2.86 7.58 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 15514 381
LE/BluGill absolute change in partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 8 11.73 mmHg 4.6 13.01 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 15518 381
LE/BluGill body temperature resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 10 37.74 degrees C 0.2 0.65 digital rectal thermometry Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 15575 381
LE/BluGill absolute change in blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 8 0.03 null 0.01 0.02 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 15608 381
LE/BluGill heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 8 482.97 beats/min 7.02 19.86 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 15787 381
LE/BluGill urine potassium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine potassium amount female 80.0 days-99.0 days 9 1.09 mEq/d 0.1 0.29 flame atomic emission spectrometry urine potassium analysis Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 52925 482
LE/BluGill urine potassium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine potassium amount male 80.0 days-99.0 days 7 1.18 mEq/d 0.06 0.15 flame atomic emission spectrometry urine potassium analysis Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 52926 482
LE/BluGill plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount male 80.0 days-99.0 days 6 0.32 mg/dl 0.02 0.05 radioimmunoassay Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 52240 482
LE/BluGill creatinine clearance controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data glomerular filtration trait female 80.0 days-99.0 days 9 2.14 ml/min 0.15 0.45 urine creatinine analysis Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 52290 482
LE/BluGill urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine albumin amount male 80.0 days-99.0 days 7 7.25 mg/d 1.35 3.56 radioimmunoassay Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 52434 482
LE/BluGill plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data renin activity female 80.0 days-99.0 days 8 3.46 ng/ml/h 1.44 4.09 radioimmunoassay Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 52578 482
LE/BluGill heart rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data heart pumping trait male 80.0 days-99.0 days 7 382.48 beats/min 3.97 10.5 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 52630 482
LE/BluGill urine total protein excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data total urine protein amount female 80.0 days-99.0 days 9 36.08 mg/d 5.08 15.23 automated urine total protein analysis Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 52729 482
LE/BluGill mean arterial blood pressure controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 8 125.06 mmHg 2.7 7.64 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 13458 381
LE/BluGill respiration rate control condition PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 13 107.84 breaths/min 3.75 13.53 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17331 381
LE/BluGill absolute change in body temperature controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 12 0.12 degrees C 0.21 0.74 digital rectal thermometry Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 13874 381
LE/BluGill mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 9 109.87 mmHg 6.68 20.03 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 13885 381
LE/BluGill tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 13 0.37 ml 0.02 0.06 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 14017 381
LE/BluGill partial pressure of blood oxygen control condition PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 8 97.99 mmHg 2.49 7.04 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 14084 381
LE/BluGill minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 13 56.55 ml/min 2.59 9.32 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19725 381
LE/BluGill absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 7 -6.29 mmHg 0.59 1.56 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 20985 381
LE/BluGill absolute change in mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 9 10.15 mmHg 1.56 4.68 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 20112 381
LE/BluGill partial pressure of blood carbon dioxide (Pco2) resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 9 30.09 mmHg 1.13 3.38 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19688 381
LE/BluGill blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 6 7.49 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18099 381
LE/BluGill mean arterial blood pressure resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 10 97.16 mmHg 1.56 4.94 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18779 381
LE/BluGill mean arterial blood pressure resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 11 107.52 mmHg 1.47 4.87 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18783 381
LE/BluGill minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 13 53.64 ml/min 1.95 7.03 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18971 381
LE/BluGill serum total protein level control condition (for 14 days) PhysGen Biochemistry data blood total protein amount male 77.0 days-91.0 days 11 6.49 g/dl 0.11 0.38 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 37421 401
LE/BluGill serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77.0 days-91.0 days 9 118.44 U/l 6.92 20.77 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 37427 401
LE/BluGill percent change in ventilation controlled sodium content diet (0 %) then controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 10 %change=VE during 2-3 min hypoxia/control during standard conditions 153.14 % 14.59 46.14 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19305 381
LE/BluGill heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49.0 days-63.0 days 9 53.56 mmHg 5.74 17.22 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49598 461
LE/BluGill heart left ventricle infarction weight to total heart left ventricle weight ratio controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49.0 days-63.0 days 9 10.66 % 2.93 8.79 digital scale post excision weight measurement Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49865 461
LE/BluGill serum phosphate level control condition (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77.0 days-91.0 days 11 8.38 mg/dl 0.41 1.35 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38843 401
LE/BluGill hematocrit control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77.0 days-91.0 days 11 45.55 % 0.42 1.4 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38871 401
LE/BluGill mean corpuscular hemoglobin concentration control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77.0 days-91.0 days 11 32.56 g/dl 0.13 0.45 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 42217 401
LE/BluGill serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77.0 days-91.0 days 9 15.22 mg/dl 1.14 3.42 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 39516 401
LE/BluGill serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77.0 days-91.0 days 10 17.2 mg/dl 1.18 3.74 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 39520 401
LE/BluGill mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77.0 days-91.0 days 9 31.91 g/dl 0.13 0.4 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 42734 401
LE/BluGill total white blood cell count control condition (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77.0 days-91.0 days 13 2.88 x 1000 cells/ul 0.25 0.91 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 42858 401
LE/BluGill serum bicarbonate level control condition (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77.0 days-91.0 days 11 20.82 mmol/l 0.44 1.47 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 43077 401
LE/BluGill blood monocyte count control condition (for 14 days) PhysGen Biochemistry data monocyte quantity male 77.0 days-91.0 days 11 0.25 x 1000 cells/ul 0.03 0.1 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 43087 401
LE/BluGill percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 10 145.48 % 8.81 27.86 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 53600 381
LE/BluGill percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 13 105.41 % 2.71 9.78 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 53616 381
LE/BluGill serum globulin level control condition (for 14 days) PhysGen Biochemistry data blood globulin amount male 77.0 days-91.0 days 11 2.26 g/dl 0.08 0.26 standard blood chemistry panel replaced obsolete serum globulin level term, 1/19/2016 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 39985 401
LE/BluGill serum glucose level control condition (for 14 days) PhysGen Biochemistry data blood glucose amount male 77.0 days-91.0 days 11 159.82 mg/dl 3.63 12.03 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 40494 401
LE/BluGill serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77.0 days-91.0 days 10 0.1 mg/dl 0.0 0.0 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 37550 401
LE/BluGill plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77.0 days-91.0 days 9 24.22 mmol/l 0.64 1.92 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 37556 401
LE/BluGill plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77.0 days-91.0 days 10 0.29 mg/dl 0.01 0.03 automated plasma creatinine analysis Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 40806 401
LE/BluGill serum chloride level control condition (for 14 days) PhysGen Biochemistry data blood chloride amount female 77.0 days-91.0 days 14 107.29 mmol/l 0.71 2.64 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 41110 401
LE/BluGill serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77.0 days-91.0 days 10 15.1 mmol/l 0.67 2.13 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 41130 401
LE/BluGill serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77.0 days-91.0 days 10 4.31 g/dl 0.07 0.21 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 41140 401
LE/BluGill serum total cholesterol level control condition (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77.0 days-91.0 days 14 164.79 mg/dl 4.18 15.63 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 37910 401
LE/BluGill serum calcium level control condition (for 14 days) PhysGen Biochemistry data blood calcium amount female 77.0 days-91.0 days 14 9.92 mg/dl 0.11 0.43 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 37931 401
LE/BluGill blood lymphocyte count control condition (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77.0 days-91.0 days 11 3.43 x 1000 cells/ul 0.26 0.86 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 37945 401
LE/BluGill red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77.0 days-91.0 days 9 9.62 x 10E6 cells/ul 0.12 0.35 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38154 401
LE/BluGill serum alkaline phosphatase activity level control condition (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77.0 days-91.0 days 14 201.29 U/l 5.45 20.41 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38175 401
LE/BluGill serum alkaline phosphatase activity level control condition (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77.0 days-91.0 days 11 282.45 U/l 14.25 47.25 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38179 401
LE/BluGill serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount female 77.0 days-91.0 days 9 107.33 mmol/l 0.47 1.41 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38185 401
LE/BluGill blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77.0 days-91.0 days 10 19.17 g/dl 0.28 0.9 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38408 401
LE/BluGill serum alanine aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77.0 days-91.0 days 14 60.64 U/l 1.77 6.61 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38618 401
LE/BluGill logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 13 -8.65 null 0.07 0.24 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 55349 522
LE/BluGill fractional change in blood vessel diameter per unit change in intravascular pressure Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77.0 days-91.0 days 13 0.05 mmHg-1 0.01 0.03 fluid-filled catheter with pressure transducer in isolated perfused lung Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57700 526
LE/BluGill methylene blue to FAPGG metabolism-surface area product ratio methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 14 0.33 null 0.03 0.12 isolated perfused lung vascular effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57738 526
LE/BluGill partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 6 27.75 mmHg 1.14 2.79 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 16372 381
LE/BluGill body weight control condition PhysGen Respiratory data body mass male 82.0 days-99.0 days 15 345.4 g 10.0 38.7 whole body digital scale Moms and pups used in studies were fed Dyets 16796 381
LE/BluGill body weight controlled sodium content diet (4 %) (for 21 days) PhysGen Vascular data body mass female 70.0 days-84.0 days 15 272.5 g 6.3 24.6 whole body digital scale Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56073 522
LE/BluGill methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 13 0.45 null 0.02 0.05 isolated perfused lung vascular effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 58577 526
LE/BluGill hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77.0 days-91.0 days 10 59.49 % 0.93 2.95 microhematocrit tube assay with visual assessment Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 58591 526
LE/BluGill body weight control condition (for 21 days) PhysGen Vascular data body mass female 70.0 days-84.0 days 14 256.9 g 6.6 24.8 whole body digital scale Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 54874 522
LE/BluGill hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 14 33.71 % 3.38 12.65 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 55002 522
LE/BluGill hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 14 29.36 % 3.99 14.92 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 55006 522
LE/BluGill concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 11 0.05 10E-7mol/l 0.01 0.03 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56461 522
LE/BluGill methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 14 10.23 ml/min/kg 0.79 2.97 isolated perfused lung vascular effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 59869 526
LE/BluGill hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 11 44.91 % 2.37 7.87 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56708 522
LE/BluGill logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70.0 days-84.0 days 15 -8.67 null 0.04 0.17 wire myography using a Digi-Med tissue force analysis system with force transducer EC50 value is moles/liter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56739 522
LE/BluGill logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70.0 days-84.0 days 14 -8.37 null 0.09 0.34 wire myography using a Digi-Med tissue force analysis system with force transducer EC50 value is moles/liter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56743 522
LE/BluGill acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 11 52.55 % 4.62 15.34 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56756 522
LE/BluGill concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 14 0.08 10E-7mol/l 0.02 0.08 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56771 522
LE/BluGill logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 14 -7.47 null 0.05 0.2 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56777 522
LE/BluGill hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 14 37.29 % 4.05 15.17 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56834 522
LE/BluGill body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass male 77.0 days-91.0 days 15 280.7 g 11.0 42.6 whole body digital scale Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 60105 526
LE/BluGill dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77.0 days-91.0 days 13 2.96 mg/kg 0.5 1.8 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 60111 526
LE/BluGill maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait female 70.0 days-84.0 days 15 2.3 g/mg 0.16 0.62 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56866 522
LE/BluGill left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 7 134.56 mmHg 4.79 12.68 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47675 461
LE/BluGill left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 11 66.25 mmHg 6.85 22.72 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45907 461
LE/BluGill left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 7 103.07 mmHg 8.69 22.99 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 46045 461
LE/BluGill arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49.0 days-63.0 days 9 6.64 ml/min/g 0.86 2.58 isolated perfused heart effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 46185 461
LE/BluGill time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49.0 days-63.0 days 9 924.89 s 92.89 278.66 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 48129 461
LE/BluGill left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 8 115.67 mmHg 4.22 11.93 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45020 461
LE/BluGill time to peak heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 11 1386.82 s 33.2 110.11 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45070 461
LE/BluGill heart contraction pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49.0 days-63.0 days 9 57.11 mmHg 3.77 11.31 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47390 461
LE/BluGill heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 11 205.11 beats/min 17.21 57.08 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45358 461