7 | skin chloride level to skin dry weight ratio | WKY/NHsd | male | 0.051 | mmol/g | standard rat chow (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) | 99135 | standard rat chow (for 8 days) | vehicle control condition (0.5 ml) (for 8 days) | |

8 | skin chloride level to skin dry weight ratio | WKY/NHsd | male | 0.052 | mmol/g | standard rat chow (for 8 days) then sunitinib (7 mg/kg/d) (for 8 days) | 99136 | standard rat chow (for 8 days) | sunitinib (7 mg/kg/d) (for 8 days) | |

7 | skin chloride level to skin dry weight ratio | WKY/NHsd | male | 0.068 | mmol/g | controlled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) | 99137 | controlled sodium content diet (8 %) (for 8 days) | 0.9% sodium chloride solution (0.9 %) (for 8 days) | vehicle control condition (0.5 ml) (for 8 days) |

8 | skin chloride level to skin dry weight ratio | WKY/NHsd | male | 0.073 | mmol/g | controlled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then sunitinib (7 mg/kg/d) (for 8 days) | 99138 | controlled sodium content diet (8 %) (for 8 days) | 0.9% sodium chloride solution (0.9 %) (for 8 days) | sunitinib (7 mg/kg/d) (for 8 days) |

7 | skin water level to skin dry weight ratio | WKY/NHsd | male | 1.223 | ml/g | standard rat chow (for 8 days) then sunitinib (0.5 ml) (for 8 days) | 99139 | standard rat chow (for 8 days) | sunitinib (0.5 ml) (for 8 days) | |

8 | skin water level to skin dry weight ratio | WKY/NHsd | male | 1.208 | ml/g | standard rat chow (for 8 days) then sunitinib (7 mg/kg/d) (for 8 days) | 99140 | standard rat chow (for 8 days) | sunitinib (7 mg/kg/d) (for 8 days) | |

7 | skin water level to skin dry weight ratio | WKY/NHsd | male | 1.432 | ml/g | controlled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) | 99141 | controlled sodium content diet (8 %) (for 8 days) | 0.9% sodium chloride solution (0.9 %) (for 8 days) | vehicle control condition (0.5 ml) (for 8 days) |

8 | skin water level to skin dry weight ratio | WKY/NHsd | male | 1.522 | ml/g | controlled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then sunitinib (7 mg/kg/d) (for 8 days) | 99142 | controlled sodium content diet (8 %) (for 8 days) | 0.9% sodium chloride solution (0.9 %) (for 8 days) | sunitinib (7 mg/kg/d) (for 8 days) |

7 | skin potassium level plus skin sodium level to skin water level ratio | WKY/NHsd | male | 0.17 | | standard rat chow (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) | 99143 | standard rat chow (for 8 days) | vehicle control condition (0.5 ml) (for 8 days) | |

8 | skin potassium level plus skin sodium level to skin water level ratio | WKY/NHsd | male | 0.167 | | standard rat chow (for 8 days) then sunitinib (7 mg/kg/d) (for 8 days) | 99144 | standard rat chow (for 8 days) | sunitinib (7 mg/kg/d) (for 8 days) | |

7 | skin potassium level plus skin sodium level to skin water level ratio | WKY/NHsd | male | 0.176 | | controlled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) | 99145 | controlled sodium content diet (8 %) (for 8 days) | 0.9% sodium chloride solution (0.9 %) (for 8 days) | vehicle control condition (0.5 ml) (for 8 days) |

8 | skin potassium level plus skin sodium level to skin water level ratio | WKY/NHsd | male | 0.171 | | controlled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then sunitinib (7 mg/kg/d) (for 8 days) | 99146 | controlled sodium content diet (8 %) (for 8 days) | 0.9% sodium chloride solution (0.9 %) (for 8 days) | sunitinib (7 mg/kg/d) (for 8 days) |

7 | skin chloride level to skin water level ratio | WKY/NHsd | male | 90 | mmol/l | standard rat chow (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) | 99147 | standard rat chow (for 8 days) | vehicle control condition (0.5 ml) (for 8 days) | |

8 | skin chloride level to skin water level ratio | WKY/NHsd | male | 92 | mmol/l | standard rat chow (for 8 days) then sunitinib (7 mg/kg/d) (for 8 days) | 99148 | standard rat chow (for 8 days) | sunitinib (7 mg/kg/d) (for 8 days) | |

7 | skin chloride level to skin water level ratio | WKY/NHsd | male | 101 | mmol/l | controlled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) | 99149 | controlled sodium content diet (8 %) (for 8 days) | 0.9% sodium chloride solution (0.9 %) (for 8 days) | vehicle control condition (0.5 ml) (for 8 days) |

8 | skin chloride level to skin water level ratio | WKY/NHsd | male | 108 | mmol/l | controlled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then sunitinib (7 mg/kg/d) (for 8 days) | 99150 | controlled sodium content diet (8 %) (for 8 days) | 0.9% sodium chloride solution (0.9 %) (for 8 days) | sunitinib (7 mg/kg/d) (for 8 days) |

7 | skin chloride level to skin water level ratio | WKY/NHsd | male | 42 | mmol/l | standard rat chow (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) | 99151 | standard rat chow (for 8 days) | vehicle control condition (0.5 ml) (for 8 days) | |

8 | skin chloride level to skin water level ratio | WKY/NHsd | male | 43 | mmol/l | standard rat chow (for 8 days) then sunitinib (7 mg/kg/d) (for 8 days) | 99152 | standard rat chow (for 8 days) | sunitinib (7 mg/kg/d) (for 8 days) | |

7 | skin chloride level to skin water level ratio | WKY/NHsd | male | 48 | mmol/l | controlled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) | 99153 | controlled sodium content diet (8 %) (for 8 days) | 0.9% sodium chloride solution (0.9 %) (for 8 days) | vehicle control condition (0.5 ml) (for 8 days) |

8 | skin chloride level to skin water level ratio | WKY/NHsd | male | 50 | mmol/l | controlled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then sunitinib (7 mg/kg/d) (for 8 days) | 99154 | controlled sodium content diet (8 %) (for 8 days) | 0.9% sodium chloride solution (0.9 %) (for 8 days) | sunitinib (7 mg/kg/d) (for 8 days) |

7 | skin potassium level to skin water level ratio | WKY/NHsd | male | 80 | mmol/l | standard rat chow (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) | 99155 | standard rat chow (for 8 days) | vehicle control condition (0.5 ml) (for 8 days) | |

8 | skin potassium level to skin water level ratio | WKY/NHsd | male | 75 | mmol/l | standard rat chow (for 8 days) then sunitinib (7 mg/kg/d) (for 8 days) | 99156 | standard rat chow (for 8 days) | sunitinib (7 mg/kg/d) (for 8 days) | |

7 | skin potassium level to skin water level ratio | WKY/NHsd | male | 71 | mmol/l | controlled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) | 99157 | controlled sodium content diet (8 %) (for 8 days) | 0.9% sodium chloride solution (0.9 %) (for 8 days) | vehicle control condition (0.5 ml) (for 8 days) |

8 | skin potassium level to skin water level ratio | WKY/NHsd | male | 69 | mmol/l | controlled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then sunitinib (7 mg/kg/d) (for 8 days) | 99158 | controlled sodium content diet (8 %) (for 8 days) | 0.9% sodium chloride solution (0.9 %) (for 8 days) | sunitinib (7 mg/kg/d) (for 8 days) |

7 | skin sodium level to skin dry weight ratio | WKY/NHsd | male | 0.11 | REQUEST NEW VALUE | standard rat chow (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) | 99131 | standard rat chow (for 8 days) | vehicle control condition (0.5 ml) (for 8 days) | |

8 | skin sodium level to skin dry weight ratio | WKY/NHsd | male | 0.112 | REQUEST NEW VALUE | standard rat chow (for 8 days) then sunitinib (7 mg/kg/d) (for 8 days) | 99132 | standard rat chow (for 8 days) | sunitinib (7 mg/kg/d) (for 8 days) | |

7 | skin sodium level to skin dry weight ratio | WKY/NHsd | male | 0.144 | REQUEST NEW VALUE | controlled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) | 99133 | controlled sodium content diet (8 %) (for 8 days) | 0.9% sodium chloride solution (0.9 %) (for 8 days) | vehicle control condition (0.5 ml) (for 8 days) |

8 | skin sodium level to skin dry weight ratio | WKY/NHsd | male | 0.164 | REQUEST NEW VALUE | controlled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then sunitinib (7 mg/kg/d) (for 8 days) | 99134 | controlled sodium content diet (8 %) (for 8 days) | 0.9% sodium chloride solution (0.9 %) (for 8 days) | sunitinib (7 mg/kg/d) (for 8 days) |