Phenominer Database Results (113 results)

 
 
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Strain Phenotype Conditions Study Experiment Name Sex Age # of Animals Formula Value Units SEM SD Method Method Site Method Duration Post Insult Time Value Method Notes Clinical Measurement Notes Record ID Study ID
SS/HsdMcwiCrl sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then phenylephrine (2 umol/l) then sodium nitroprusside (0.316 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasodilation trait male 112 days 6 [(maximum PE response − SNP response)/(maximum PE response − baseline before PE constriction)] × 100 98.54 % 0.51 1.25 wire myography mesenteric artery 0.0 0 BCA assay 67674 735
SS/HsdMcwiCrl logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then phenylephrine (2 umol/l) then acetylcholine (0.001-9.5 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasodilation trait male 112 days 6 logEC50 -7.2 null 0.1 0.24 wire myography mesenteric artery 0.0 0 84643 735
SS/HsdMcwiCrl logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then phenylephrine (2 umol/l) then NG-nitroarginine methyl ester (100 umol/l) then acetylcholine (0.001-9.5 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasodilation trait male 112 days 5 logEC50 -6.7 null 0.2 0.45 wire myography mesenteric artery 0.0 0 84647 735
SS/HsdMcwiCrl acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then phenylephrine (1 umol/l) then NG-nitroarginine methyl ester (100 umol/l) then acetylcholine (31.6 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasodilation trait male 112 days 10 [(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] × 100 -29.33 % 4.38 13.85 wire myography aorta 0.0 0 84657 735
SS/HsdMcwiCrl acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then phenylephrine (1 umol/l) then NG-nitroarginine methyl ester (100 umol/l) then acetylcholine (31.6 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasodilation trait male 112 days 7 [(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] × 100 -12.94 % 4.38 11.59 wire myography aorta 0.0 0 84658 735
SS/HsdMcwiCrl acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then phenylephrine (1 umol/l) then NG-nitroarginine methyl ester (100 umol/l) then acetylcholine (31.6 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasodilation trait male 112 days 6 [(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] × 100 -16.62 % 7.27 17.81 wire myography aorta 0.0 0 84659 735
SS/HsdMcwiCrl sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then phenylephrine (1 umol/l) then sodium nitroprusside (3.16 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasodilation trait male 112 days 10 [(maximum PE response − SNP response)/(maximum PE response − baseline before PE constriction)] × 100 96.25 % 1.6 5.06 wire myography aorta 0.0 0 BCA assay 84661 735
SS/HsdMcwiCrl logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then phenylephrine (1 umol/l) then sodium nitroprusside (0-9.5 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasodilation trait male 112 days 10 logEC50 -7.93 null 0.15 0.47 wire myography aorta 0.0 0 84669 735
SS/HsdMcwiCrl phenylephrine-induced blood vessel contractile force expressed as percent of force at baseline controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then phenylephrine (31.6 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasoconstriction trait male 112 days 10 [(response to vasoconstrictor - baseline before constriction)/baseline before constriction] x 100 607.58 % 51.55 163.02 wire myography mesenteric artery 0.0 0 phenylephrine-induced blood vessel constriction expressed as percent of force at baseline 84673 735
SS/HsdMcwiCrl phenylephrine-induced blood vessel contractile force expressed as percent of force at baseline controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then phenylephrine (31.6 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasoconstriction trait male 112 days 6 [(response to vasoconstrictor - baseline before constriction)/baseline before constriction] x 100 641.52 % 62.37 152.77 wire myography mesenteric artery 0.0 0 phenylephrine-induced blood vessel constriction expressed as percent of force at baseline 84675 735
SS/HsdMcwiCrl phenylephrine-induced blood vessel contractile force expressed as percent of force at baseline controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then NG-nitroarginine methyl ester (100 umol/l) (for 0.2 hours) then phenylephrine (31.6 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasoconstriction trait male 112 days 6 [(response to vasoconstrictor - baseline before constriction)/baseline before constriction] x 100 564.27 % 57.82 141.63 wire myography mesenteric artery 0.0 0 phenylephrine-induced blood vessel constriction expressed as percent of force at baseline 84678 735
SS/HsdMcwiCrl potassium chloride-induced blood vessel contractile force expressed as percent of force at baseline controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then potassium chloride solution (100 mmol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasoconstriction trait male 112 days 10 [(response to vasoconstrictor - baseline before constriction)/baseline before constriction] x 100 301.44 % 27.24 86.14 wire myography mesenteric artery 0.0 0 KCl-induced blood vessel constriction expressed as percent of force at baseline 84681 735
WKY/NCrl acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel salidroside (40 mg/kg) (for 28 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. vasodilation trait male 168 days 7 90.64 % 2.0 5.29 wire myography 0.0 0 103591 2827
WKY/NCrl sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel vehicle control condition (for 28 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. vasodilation trait male 168 days 7 97.56 % 1.02 2.7 wire myography 0.0 0 103598 2827
WKY/NCrl sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel salidroside (40 mg/kg) (for 28 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. vasodilation trait male 168 days 7 98.36 % 0.98 2.59 wire myography 0.0 0 103599 2827
GK sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel salidroside (40 mg/kg) (for 28 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. vasodilation trait male 168 days 7 97.14 % 0.86 2.28 wire myography 0.0 0 103601 2827
WKY/NCrl logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) salidroside (40 mg/kg) (for 28 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. vasodilation trait male 168 days 7 -7.72 null 0.03 0.08 wire myography 0.0 0 103603 2827
GK logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) vehicle control condition (for 28 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. vasodilation trait male 168 days 8 -7.39 null 0.04 0.11 wire myography 0.0 0 103604 2827
GK logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) salidroside (40 mg/kg) (for 28 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. vasodilation trait male 168 days 7 -7.29 null 0.02 0.06 wire myography 0.0 0 103605 2827
GK acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel vehicle control condition (for 28 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. vasodilation trait male 168 days 8 96.96 % 2.2 6.22 wire myography 0.0 0 103608 2827
GK logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) salidroside (40 mg/kg) (for 28 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. vasodilation trait male 168 days 7 -8.35 null 0.12 0.32 wire myography 0.0 0 103613 2827
WKY/NCrl acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel control condition (for 0 hours) Steireif C, etal., J Hypertens. 2013 Nov;31(11):2203-12; discussion 2212. doi: 10.1097/HJH.0b013e3283642384. vasodilation trait male 84 days 10 81.1 % 3.0 9.49 wire myography 0.0 0 109367 3141
SHR/Bbb acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel control condition (for 0 hours) Steireif C, etal., J Hypertens. 2013 Nov;31(11):2203-12; discussion 2212. doi: 10.1097/HJH.0b013e3283642384. vasodilation trait male 84 days 10 68.1 % 4.3 13.6 wire myography 0.0 0 109368 3141
WKY/NCrl norepinephrine-induced blood vessel contractile force expressed as percent of force of contraction to KCL control condition (for 0 hours) Steireif C, etal., J Hypertens. 2013 Nov;31(11):2203-12; discussion 2212. doi: 10.1097/HJH.0b013e3283642384. vasoconstriction trait male 84 days 10 105.7 % 11.0 34.79 wire myography 0.0 0 norepinephrine-induced blood vessel contractile force expressed as percent of force at baseline (CMO:0003676) 109377 3141
MWF/FubRkb norepinephrine-induced blood vessel contractile force expressed as percent of force of contraction to KCL control condition (for 0 hours) Steireif C, etal., J Hypertens. 2013 Nov;31(11):2203-12; discussion 2212. doi: 10.1097/HJH.0b013e3283642384. vasoconstriction trait male 84 days 10 148.4 % 16.0 50.6 wire myography 0.0 0 norepinephrine-induced blood vessel contractile force expressed as percent of force at baseline (CMO:0003676) 109379 3141
MWF-Chr 6SHR/Rkb negative logarithm of the molar concentration of norepinephrine at which the force of blood vessel contraction is half the maximum value control condition (for 0 hours) Steireif C, etal., J Hypertens. 2013 Nov;31(11):2203-12; discussion 2212. doi: 10.1097/HJH.0b013e3283642384. vasoconstriction trait male 84 days 10 8.1 null 0.1 0.32 wire myography 0.0 0 logarithm of the concentration of norepinephrine at which the force of blood vessel contraction is half the maximum value (CMO:0003677) 109386 3141
Crl:WI norepinephrine-induced blood vessel contractile force expressed as percent of force of contraction to KCL finerenone (for 28 days) Gil-Ortega M, etal., Am J Nephrol. 2020 Feb 21:1-10. doi: 10.1159/000506275. vasoconstriction trait male 114 days 10 65.7 % 5.6 17.71 wire myography 0.0 0 109440 3140
MWF/FubRkb norepinephrine-induced blood vessel contractile force expressed as percent of force of contraction to KCL vehicle control condition (for 28 days) Gil-Ortega M, etal., Am J Nephrol. 2020 Feb 21:1-10. doi: 10.1159/000506275. vasoconstriction trait male 114 days 10 77.8 % 10.2 32.26 wire myography 0.0 0 109441 3140
MWF/FubRkb norepinephrine-induced blood vessel contractile force expressed as percent of force of contraction to KCL finerenone (for 28 days) Gil-Ortega M, etal., Am J Nephrol. 2020 Feb 21:1-10. doi: 10.1159/000506275. vasoconstriction trait male 114 days 10 52.9 % 7.9 24.98 wire myography 0.0 0 109442 3140
MWF/FubRkb negative logarithm of the molar concentration of norepinephrine at which the force of blood vessel contraction is half the maximum value vehicle control condition (for 28 days) Gil-Ortega M, etal., Am J Nephrol. 2020 Feb 21:1-10. doi: 10.1159/000506275. vasoconstriction trait male 114 days 10 6.9 null 0.1 0.32 wire myography 0.0 0 109445 3140
MWF/FubRkb negative logarithm of the molar concentration of norepinephrine at which the force of blood vessel contraction is half the maximum value finerenone (for 28 days) Gil-Ortega M, etal., Am J Nephrol. 2020 Feb 21:1-10. doi: 10.1159/000506275. vasoconstriction trait male 114 days 10 6.7 null 0.1 0.32 wire myography 0.0 0 109446 3140
SS/HsdMcwiCrl logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then phenylephrine (2 umol/l) then NG-nitroarginine methyl ester (100 umol/l) then acetylcholine (0.001-9.5 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasodilation trait male 112 days 8 logEC50 -6.3 null 0.2 0.57 wire myography mesenteric artery 0.0 0 84645 735
SS/HsdMcwiCrl logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) then phenylephrine (2 umol/l) then sodium nitroprusside (0.316 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasodilation trait male 112 days 7 logEC50 -7.9 null 0.12 0.32 wire myography mesenteric artery 0.0 0 BCA assay 84648 735
SS/HsdMcwiCrl acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) then phenylephrine (1 umol/l) then NG-nitroarginine methyl ester (100 umol/l) (for 0.2 hours) then acetylcholine (31.6 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasodilation trait male 112 days 6 [(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] × 100 -19.03 % 4.01 9.82 wire myography aorta 0.0 0 BCA assay 84656 735
SS/HsdMcwiCrl acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then phenylephrine (2 umol/l) then acetylcholine (3.16 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasodilation trait male 112 days 10 [(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] × 100 99.53 % 0.41 1.3 wire myography mesenteric artery 0.0 0 69617 735
SS/HsdMcwiCrl phenylephrine-induced blood vessel contractile force expressed as percent of force at baseline controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then phenylephrine (31.6 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasoconstriction trait male 112 days 6 [(response to vasoconstrictor - baseline before constriction)/baseline before constriction] x 100 542.39 % 49.85 122.11 wire myography mesenteric artery 0.0 0 phenylephrine-induced blood vessel constriction expressed as percent of force at baseline 84674 735
SS/HsdMcwiCrl phenylephrine-induced blood vessel contractile force expressed as percent of force at baseline controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then NG-nitroarginine methyl ester (100 umol/l) (for 0.2 hours) then phenylephrine (31.6 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasoconstriction trait male 112 days 5 [(response to vasoconstrictor - baseline before constriction)/baseline before constriction] x 100 665.33 % 79.91 178.68 wire myography mesenteric artery 0.0 0 phenylephrine-induced blood vessel constriction expressed as percent of force at baseline 84679 735
SS/HsdMcwiCrl sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) then phenylephrine (2 umol/l) then sodium nitroprusside (0.316 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasodilation trait male 112 days 7 [(maximum PE response − SNP response)/(maximum PE response − baseline before PE constriction)] × 100 97.36 % 0.65 1.72 wire myography mesenteric artery 0.0 0 BCA assay 67671 735
SS/HsdMcwiCrl acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then phenylephrine (2 umol/l) then sodium nitroprusside (0.316 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasodilation trait male 112 days 7 [(maximum PE response − SNP response)/(maximum PE response − baseline before PE constriction)] × 100 98.24 % 0.82 2.17 wire myography mesenteric artery 0.0 0 BCA assay 67673 735
SS/HsdMcwiCrl acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) then phenylephrine (2 umol/l) then acetylcholine (3.16 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasodilation trait male 112 days 6 [(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] × 100 99.71 % 0.27 0.66 wire myography mesenteric artery 0.0 0 BCA assay 69616 735
SS/HsdMcwiCrl acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then phenylephrine (2 umol/l) then acetylcholine (3.16 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasodilation trait male 112 days 6 [(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] × 100 100.14 % 0.37 0.91 wire myography mesenteric artery 0.0 0 69619 735
SS/HsdMcwiCrl acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then phenylephrine (2 umol/l) then NG-nitroarginine methyl ester (100 umol/l) then acetylcholine (3.16 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasodilation trait male 112 days 10 [(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] × 100 64.5 % 15.34 48.51 wire myography mesenteric artery 0.0 0 69621 735
SS/HsdMcwiCrl logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then phenylephrine (2 umol/l) then acetylcholine (0.001-9.5 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasodilation trait male 112 days 10 logEC50 -7.4 null 0.1 0.32 wire myography mesenteric artery 0.0 0 84641 735
SS/HsdMcwiCrl logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then phenylephrine (2 umol/l) then NG-nitroarginine methyl ester (100 umol/l) then acetylcholine (0.001-9.5 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasodilation trait male 112 days 6 logEC50 -6.6 null 0.1 0.24 wire myography mesenteric artery 0.0 0 84646 735
SS/HsdMcwiCrl sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then phenylephrine (1 umol/l) then sodium nitroprusside (3.16 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasodilation trait male 112 days 6 [(maximum PE response − SNP response)/(maximum PE response − baseline before PE constriction)] × 100 99.39 % 0.74 1.81 wire myography aorta 0.0 0 BCA assay 84663 735
SS/HsdMcwiCrl potassium chloride-induced blood vessel contractile force expressed as percent of force at baseline controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) then potassium chloride solution (100 mmol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasoconstriction trait male 112 days 7 [(response to vasoconstrictor - baseline before constriction)/baseline before constriction] x 100 312.35 % 20.21 53.47 wire myography mesenteric artery 0.0 0 Kcl-induced blood vessel constriction expressed as percent of force at baseline 84680 735
GK logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) vehicle control condition (for 28 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. vasodilation trait male 168 days 8 -7.29 null 0.09 0.26 wire myography 0.0 0 103588 2827
GK sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel vehicle control condition (for 28 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. vasodilation trait male 168 days 8 94.07 % 1.13 3.18 wire myography 0.0 0 103600 2827
GK logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) vehicle control condition (for 28 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. vasodilation trait male 168 days 8 -8.74 null 0.57 1.61 wire myography 0.0 0 103612 2827
Crl:WI acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel vehicle control condition (for 28 days) Gil-Ortega M, etal., Am J Nephrol. 2020 Feb 21:1-10. doi: 10.1159/000506275. vasodilation trait male 114 days 10 90.3 % 1.2 3.79 wire myography mesenteric artery 0.0 0 109431 3140
Crl:WI negative logarithm of the molar concentration of norepinephrine at which the force of blood vessel contraction is half the maximum value vehicle control condition (for 28 days) Gil-Ortega M, etal., Am J Nephrol. 2020 Feb 21:1-10. doi: 10.1159/000506275. vasoconstriction trait male 114 days 10 6.7 null 0.1 0.32 wire myography 0.0 0 109443 3140
MWF-Chr 8SHR/Rkb acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel control condition (for 0 hours) Steireif C, etal., J Hypertens. 2013 Nov;31(11):2203-12; discussion 2212. doi: 10.1097/HJH.0b013e3283642384. vasodilation trait male 84 days 10 83.4 % 7.0 22.14 wire myography 0.0 0 109370 3141
MWF-Chr 6SHR/Rkb acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel control condition (for 0 hours) Steireif C, etal., J Hypertens. 2013 Nov;31(11):2203-12; discussion 2212. doi: 10.1097/HJH.0b013e3283642384. vasodilation trait male 84 days 10 64.0 % 3.8 12.02 wire myography 0.0 0 109371 3141
MWF-Chr 8SHR/Rkb negative logarithm of the molar concentration of norepinephrine at which the force of blood vessel contraction is half the maximum value control condition (for 0 hours) Steireif C, etal., J Hypertens. 2013 Nov;31(11):2203-12; discussion 2212. doi: 10.1097/HJH.0b013e3283642384. vasoconstriction trait male 84 days 10 7.7 null 0.1 0.32 wire myography 0.0 0 logarithm of the concentration of norepinephrine at which the force of blood vessel contraction is half the maximum value (CMO:0003677) 109385 3141
SS/HsdMcwiCrl logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then phenylephrine (1 umol/l) then acetylcholine (0-95 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasodilation trait male 112 days 7 logEC50 -6.33 null 0.25 0.66 wire myography aorta 0.0 0 84665 735
GK sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel salidroside (40 mg/kg) (for 28 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. vasodilation trait male 168 days 7 98.78 % 1.82 4.82 wire myography 0.0 0 103617 2827
SS/HsdMcwiCrl sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then phenylephrine (2 umol/l) then sodium nitroprusside (0.316 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasodilation trait male 112 days 10 [(maximum PE response − SNP response)/(maximum PE response − baseline before PE constriction)] × 100 96.65 % 1.91 6.04 wire myography mesenteric artery 0.0 0 BCA assay 67672 735
SS/HsdMcwiCrl acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then phenylephrine (1 umol/l) then acetylcholine (31.6 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasodilation trait male 112 days 4 [(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] × 100 80.04 % 2.63 5.26 wire myography aorta 0.0 0 84654 735
SS/HsdMcwiCrl logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then phenylephrine (2 umol/l) then acetylcholine (0.001-9.5 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasodilation trait male 112 days 4 logEC50 -7.1 null 0.1 0.2 wire myography mesenteric artery 0.0 0 logEC50 84640 735
SS/HsdMcwiCrl logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then phenylephrine (1 umol/l) then acetylcholine (0.001-95 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasodilation trait male 112 days 5 logEC50 -6.49 null 0.09 0.2 wire myography aorta 0.0 0 84667 735
SS/HsdMcwiCrl logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then phenylephrine (1 umol/l) then sodium nitroprusside (0-9.5 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasodilation trait male 112 days 7 logEC50 -8.37 null 0.13 0.34 wire myography aorta 0.0 0 84670 735
SS/HsdMcwiCrl phenylephrine-induced blood vessel contractile force expressed as percent of force at baseline controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then NG-nitroarginine methyl ester (100 umol/l) (for 0.2 hours) then phenylephrine (31.6 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasoconstriction trait male 112 days 9 [(response to vasoconstrictor - baseline before constriction)/baseline before constriction] x 100 626.89 % 61.39 184.17 wire myography mesenteric artery 0.0 0 phenylephrine-induced blood vessel constriction expressed as percent of force at baseline 84677 735
GK acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel salidroside (40 mg/kg) (for 28 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. vasodilation trait male 168 days 7 98.82 % 1.19 3.15 wire myography 0.0 0 103609 2827
GK sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel vehicle control condition (for 28 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. vasodilation trait male 168 days 8 86.87 % 3.06 8.65 wire myography 0.0 0 103616 2827
SHR/FubRkb norepinephrine-induced blood vessel contractile force expressed as percent of force of contraction to KCL control condition (for 0 hours) Steireif C, etal., J Hypertens. 2013 Nov;31(11):2203-12; discussion 2212. doi: 10.1097/HJH.0b013e3283642384. vasoconstriction trait male 84 days 10 147.4 % 18.0 56.92 wire myography 0.0 0 norepinephrine-induced blood vessel contractile force expressed as percent of force at baseline (CMO:0003676) 109378 3141
MWF-Chr 8SHR/Rkb norepinephrine-induced blood vessel contractile force expressed as percent of force of contraction to KCL control condition (for 0 hours) Steireif C, etal., J Hypertens. 2013 Nov;31(11):2203-12; discussion 2212. doi: 10.1097/HJH.0b013e3283642384. vasoconstriction trait male 84 days 10 87.2 % 18.0 56.92 wire myography 0.0 0 norepinephrine-induced blood vessel contractile force expressed as percent of force at baseline (CMO:0003676) 109380 3141
SHR/FubRkb negative logarithm of the molar concentration of norepinephrine at which the force of blood vessel contraction is half the maximum value control condition (for 0 hours) Steireif C, etal., J Hypertens. 2013 Nov;31(11):2203-12; discussion 2212. doi: 10.1097/HJH.0b013e3283642384. vasoconstriction trait male 84 days 10 7.6 null 0.2 0.63 wire myography 0.0 0 logarithm of the concentration of norepinephrine at which the force of blood vessel contraction is half the maximum value (CMO:0003677) 109383 3141
MWF/FubRkb negative logarithm of the molar concentration of norepinephrine at which the force of blood vessel contraction is half the maximum value control condition (for 0 hours) Steireif C, etal., J Hypertens. 2013 Nov;31(11):2203-12; discussion 2212. doi: 10.1097/HJH.0b013e3283642384. vasoconstriction trait male 84 days 10 8.3 null 0.2 0.63 wire myography 0.0 0 logarithm of the concentration of norepinephrine at which the force of blood vessel contraction is half the maximum value (CMO:0003677) 109384 3141
Crl:WI negative logarithm of the molar concentration of norepinephrine at which the force of blood vessel contraction is half the maximum value finerenone (for 28 days) Gil-Ortega M, etal., Am J Nephrol. 2020 Feb 21:1-10. doi: 10.1159/000506275. vasoconstriction trait male 114 days 10 6.9 null 0.1 0.32 wire myography 0.0 0 109444 3140
SS/HsdMcwiCrl logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then phenylephrine (2 umol/l) then acetylcholine (0.001-9.5 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasodilation trait male 112 days 6 logEC50 -7.2 null 0.1 0.24 wire myography mesenteric artery 0.0 0 84642 735
SS/HsdMcwiCrl acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then phenylephrine (1 umol/l) then acetylcholine (31.6 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasodilation trait male 112 days 7 [(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] × 100 73.42 % 5.62 14.87 wire myography aorta 0.0 0 84653 735
SS/HsdMcwiCrl acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) then phenylephrine (2 umol/l) then NG-nitroarginine methyl ester (100 umol/l) (for 0.2 hours) then acetylcholine (3.16 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasodilation trait male 112 days 5 [(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] × 100 94.99 % 0.39 0.87 wire myography mesenteric artery 0.0 0 BCA assay 69620 735
SS/HsdMcwiCrl logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) then phenylephrine (1 umol/l) then sodium nitroprusside (0-9.5 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasodilation trait male 112 days 6 logEC50 -8.08 null 0.11 0.27 wire myography aorta 0.0 0 BCA assay 84668 735
SS/HsdMcwiCrl logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) then phenylephrine (2 umol/l) then NG-nitroarginine methyl ester (100 umol/l) (for 0.2 hours) then acetylcholine (0.001-9.5 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasodilation trait male 112 days 5 logEC50 -6.2 null 0.1 0.22 wire myography mesenteric artery 0.0 0 BCA assay 84644 735
SS/HsdMcwiCrl logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then phenylephrine (2 umol/l) then sodium nitroprusside (0.316 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasodilation trait male 112 days 10 logEC50 -8.0 null 0.09 0.28 wire myography mesenteric artery 0.0 0 BCA assay 84649 735
SS/HsdMcwiCrl acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) then phenylephrine (1 umol/l) then acetylcholine (31.6 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasodilation trait male 112 days 4 [(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] × 100 70.84 % 4.18 8.36 wire myography aorta 0.0 0 BCA assay 84652 735
SS/HsdMcwiCrl acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then phenylephrine (1 umol/l) then acetylcholine (31.6 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasodilation trait male 112 days 5 [(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] × 100 78.37 % 1.3 2.91 wire myography aorta 0.0 0 84655 735
SS/HsdMcwiCrl phenylephrine-induced blood vessel contractile force expressed as percent of force at baseline controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) then phenylephrine (31.6 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasoconstriction trait male 112 days 7 [(response to vasoconstrictor - baseline before constriction)/baseline before constriction] x 100 694.94 % 34.53 91.36 wire myography mesenteric artery 0.0 0 phenylephrine-induced blood vessel constriction expressed as percent of force at baseline 84672 735
WKY/NCrl logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) salidroside (40 mg/kg) (for 28 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. vasodilation trait male 168 days 7 -7.1 null 0.04 0.11 wire myography 0 103587 2827
GK acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel vehicle control condition (for 28 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. vasodilation trait male 168 days 8 67.1 % 3.32 9.39 wire myography 0.0 0 103592 2827
WKY/NCrl logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) salidroside (40 mg/kg) (for 28 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. vasodilation trait male 168 days 7 -8.04 null 0.04 0.12 wire myography 0.0 0 103595 2827
WKY/NCrl acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel vehicle control condition (for 28 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. vasodilation trait male 168 days 7 99.75 % 2.32 6.14 wire myography 0.0 0 103606 2827
WKY/NCrl acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel salidroside (40 mg/kg) (for 28 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. vasodilation trait male 168 days 7 96.2 % 1.31 3.47 wire myography 0.0 0 103607 2827
WKY/NCrl logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) vehicle control condition (for 28 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. vasodilation trait male 168 days 7 -8.15 null 0.09 0.24 wire myography 0.0 0 103610 2827
MWF/FubRkb acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel control condition (for 0 hours) Steireif C, etal., J Hypertens. 2013 Nov;31(11):2203-12; discussion 2212. doi: 10.1097/HJH.0b013e3283642384. vasodilation trait male 84 days 10 58.9 % 3.7 11.7 wire myography 0.0 0 109369 3141
MWF-Chr 6SHR/Rkb norepinephrine-induced blood vessel contractile force expressed as percent of force of contraction to KCL control condition (for 0 hours) Steireif C, etal., J Hypertens. 2013 Nov;31(11):2203-12; discussion 2212. doi: 10.1097/HJH.0b013e3283642384. vasoconstriction trait male 84 days 10 128.2 % 17.0 53.76 wire myography 0.0 0 norepinephrine-induced blood vessel contractile force expressed as percent of force at baseline (CMO:0003676) 109381 3141
WKY/NCrl negative logarithm of the molar concentration of norepinephrine at which the force of blood vessel contraction is half the maximum value control condition (for 0 hours) Steireif C, etal., J Hypertens. 2013 Nov;31(11):2203-12; discussion 2212. doi: 10.1097/HJH.0b013e3283642384. vasoconstriction trait male 84 days 10 7.8 null 0.2 0.63 wire myography 0.0 0 logarithm of the concentration of norepinephrine at which the force of blood vessel contraction is half the maximum value (CMO:0003677) 109382 3141
Crl:WI acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel finerenone (10 mg/kg/d) (for 28 days) Gil-Ortega M, etal., Am J Nephrol. 2020 Feb 21:1-10. doi: 10.1159/000506275. vasodilation trait male 114 days 10 91.5 % 1.7 5.38 wire myography mesenteric artery 0.0 0 109432 3140
MWF/FubRkb acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel finerenone (10 mg/kg/d) (for 28 days) Gil-Ortega M, etal., Am J Nephrol. 2020 Feb 21:1-10. doi: 10.1159/000506275. vasodilation trait male 114 days 10 89.6 % 1.6 5.06 wire myography mesenteric artery 0.0 0 109434 3140
SS/HsdMcwiCrl sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) then phenylephrine (1 umol/l) then sodium nitroprusside (3.16 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasodilation trait male 112 days 6 [(maximum PE response − SNP response)/(maximum PE response − baseline before PE constriction)] × 100 98.76 % 0.68 1.67 wire myography aorta 0.0 0 BCA assay 84660 735
SS/HsdMcwiCrl logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then phenylephrine (1 umol/l) then sodium nitroprusside (0-9.5 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasodilation trait male 112 days 6 logEC50 -8.24 null 0.13 0.32 wire myography aorta 0.0 0 84671 735
SS/HsdMcwiCrl acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then phenylephrine (2 umol/l) then acetylcholine (3.16 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasodilation trait male 112 days 6 [(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] × 100 100.24 % 0.28 0.69 wire myography mesenteric artery 0.0 0 69618 735
SS/HsdMcwiCrl acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then phenylephrine (2 umol/l) then NG-nitroarginine methyl ester (100 umol/l) then acetylcholine (3.16 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasodilation trait male 112 days 6 [(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] × 100 91.96 % 2.76 6.76 wire myography mesenteric artery 0.0 0 69622 735
SS/HsdMcwiCrl logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then phenylephrine (2 umol/l) then sodium nitroprusside (0.316 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasodilation trait male 112 days 6 logEC50 -7.9 null 0.17 0.42 wire myography mesenteric artery 0.0 0 BCA assay 84650 735
SS/HsdMcwiCrl logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then phenylephrine (1 umol/l) then acetylcholine (0-95 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasodilation trait male 112 days 4 logEC50 -6.31 null 0.1 0.2 wire myography aorta 0.0 0 logEC50 84664 735
SS/HsdMcwiCrl logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then phenylephrine (1 umol/l) then acetylcholine (0-95 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasodilation trait male 112 days 4 logEC50 -6.49 null 0.13 0.26 wire myography aorta 0.0 0 84666 735
WKY/NCrl logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) vehicle control condition (for 28 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. vasodilation trait male 168 days 7 -7.07 null 0.05 0.14 wire myography 0 103586 2827
GK logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) salidroside (40 mg/kg) (for 28 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. vasodilation trait male 168 days 7 -7.3 null 0.05 0.13 wire myography 0 103589 2827
WKY/NCrl acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel vehicle control condition (for 28 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. vasodilation trait male 168 days 7 89.88 % 2.56 6.77 wire myography 0.0 0 103590 2827
GK acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel salidroside (40 mg/kg) (for 28 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. vasodilation trait male 168 days 7 81.86 % 1.91 5.04 wire myography 0.0 0 103593 2827
WKY/NCrl logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) vehicle control condition (for 28 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. vasodilation trait male 168 days 7 -8.06 null 0.05 0.13 wire myography 0.0 0 103594 2827
GK logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) vehicle control condition (for 28 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. vasodilation trait male 168 days 8 -7.96 null 0.05 0.14 wire myography 0.0 0 103596 2827
GK logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) salidroside (40 mg/kg) (for 28 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. vasodilation trait male 168 days 7 -8.21 null 0.06 0.16 wire myography 0.0 0 103597 2827
WKY/NCrl logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) vehicle control condition (for 28 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. vasodilation trait male 168 days 7 -7.6 null 0.05 0.13 wire myography 0.0 0 103602 2827
WKY/NCrl sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel vehicle control condition (for 28 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. vasodilation trait male 168 days 7 96.54 % 1.9 5.03 wire myography 0.0 0 103614 2827
WKY/NCrl sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel salidroside (40 mg/kg) (for 28 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. vasodilation trait male 168 days 7 90.13 % 1.55 4.1 wire myography 0.0 0 103615 2827
MWF/FubRkb acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel vehicle control condition (for 28 days) Gil-Ortega M, etal., Am J Nephrol. 2020 Feb 21:1-10. doi: 10.1159/000506275. vasodilation trait male 114 days 10 82.3 % 3.0 9.49 wire myography mesenteric artery 0.0 0 109433 3140
Crl:WI norepinephrine-induced blood vessel contractile force expressed as percent of force of contraction to KCL vehicle control condition (for 28 days) Gil-Ortega M, etal., Am J Nephrol. 2020 Feb 21:1-10. doi: 10.1159/000506275. vasoconstriction trait male 114 days 10 51.3 % 4.7 14.86 wire myography 0.0 0 109439 3140
SS/HsdMcwiCrl logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then phenylephrine (2 umol/l) then sodium nitroprusside (0.316 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasodilation trait male 112 days 5 logEC50 -8.4 null 0.21 0.47 wire myography mesenteric artery 0.0 0 BCA assay 84651 735
SS/HsdMcwiCrl acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then phenylephrine (2 umol/l) then NG-nitroarginine methyl ester (100 umol/l) then acetylcholine (3.16 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasodilation trait male 112 days 6 [(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] × 100 92.95 % 1.46 3.58 wire myography mesenteric artery 0.0 0 69623 735
SS/HsdMcwiCrl acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then phenylephrine (1 umol/l) then sodium nitroprusside (3.16 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasodilation trait male 112 days 0 [(maximum PE response − SNP response)/(maximum PE response − baseline before PE constriction)] × 100 95.47 % 2.53 wire myography aorta 0.0 0 BCA assay 84662 735
SS/HsdMcwiCrl phenylephrine-induced blood vessel contractile force expressed as percent of force at baseline controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) then NG-nitroarginine methyl ester (100 umol/l) (for 0.2 hours) then phenylephrine (31.6 umol/l) Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. vasoconstriction trait male 112 days 7 [(response to vasoconstrictor - baseline before constriction)/baseline before constriction] x 100 756.89 % 61.56 162.87 wire myography mesenteric artery 0.0 0 phenylephrine-induced blood vessel constriction expressed as percent of force at baseline 84676 735
WKY/NCrl logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) salidroside (40 mg/kg) (for 28 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. vasodilation trait male 168 days 7 -8.21 null 0.07 0.19 wire myography 0.0 0 103611 2827