SHR/NCrl |
creatinine clearance |
controlled sodium content diet (4 %) (between 17 and 36 days) |
PhysGen Renal A data |
glomerular filtration trait |
female |
87 days-120 days |
5 |
0.97 |
ml/min |
0.1 |
0.22 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms and pups used in studies were fed Dyets |
51800 |
481 |
SS-Chr 18BN/Mcwi |
creatinine clearance |
controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) |
PhysGen Renal A data |
glomerular filtration trait |
female |
87 days-120 days |
4 |
1.03 |
ml/min |
0.2 |
0.41 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms and pups used in studies were fed Teklad |
51055 |
481 |
SHR/NCrl |
creatinine clearance |
controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) |
PhysGen Renal A data |
glomerular filtration trait |
female |
87 days-120 days |
4 |
0.59 |
ml/min |
0.17 |
0.33 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms and pups used in studies were fed Teklad |
51060 |
481 |
BN/NHsdMcwi |
creatinine clearance |
controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) |
PhysGen Renal A data |
glomerular filtration trait |
male |
87 days-120 days |
3 |
1.39 |
ml/min |
0.23 |
0.41 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms and pups used in studies were fed Teklad |
51063 |
481 |
SS-Chr 18BN/Mcwi |
creatinine clearance |
controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) |
PhysGen Renal A data |
glomerular filtration trait |
female |
87 days-120 days |
2 |
0.73 |
ml/min |
0.02 |
0.02 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks |
51451 |
481 |
FHH-Chr 8BN/Mcwi |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
female |
80 days-99 days |
6 |
1.35 |
ml/min |
0.16 |
0.4 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52341 |
482 |
FHH-Chr 3BN/Mcwi |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
female |
80 days-99 days |
1 |
0.7 |
ml/min |
|
|
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52344 |
482 |
FHH/EurMcwi |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
male |
80 days-99 days |
39 |
1.44 |
ml/min |
0.09 |
0.57 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52360 |
482 |
FHH-Chr 14BN/Mcwi |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
male |
80 days-99 days |
8 |
1.55 |
ml/min |
0.16 |
0.45 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52363 |
482 |
FHH-Chr 2BN/Mcwi |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
male |
80 days-99 days |
4 |
2.06 |
ml/min |
0.53 |
1.06 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52365 |
482 |
FHH-Chr 17BN/Mcwi |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
male |
80 days-99 days |
6 |
0.89 |
ml/min |
0.26 |
0.64 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52370 |
482 |
FHH-Chr 9BN/Mcwi |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
female |
80 days-99 days |
3 |
1.57 |
ml/min |
1.04 |
1.8 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52376 |
482 |
FHH/EurMcwi |
creatinine clearance |
controlled sodium content diet (4 %) (between 17 and 36 days) |
PhysGen Renal A data |
glomerular filtration trait |
male |
87 days-120 days |
6 |
1.72 |
ml/min |
0.12 |
0.29 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks |
51936 |
481 |
SHR/NCrl |
creatinine clearance |
controlled sodium content diet (4 %) (between 17 and 36 days) |
PhysGen Renal A data |
glomerular filtration trait |
female |
87 days-120 days |
6 |
0.78 |
ml/min |
0.07 |
0.16 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms and pups used in studies were fed Teklad |
51952 |
481 |
SS-Chr 20BN/Mcwi |
creatinine clearance |
controlled sodium content diet (4 %) (between 17 and 36 days) |
PhysGen Renal A data |
glomerular filtration trait |
male |
87 days-120 days |
12 |
1.5 |
ml/min |
0.09 |
0.31 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms and pups used in studies were fed Teklad |
51953 |
481 |
BN/NHsdMcwi |
creatinine clearance |
controlled sodium content diet (4 %) (between 17 and 36 days) |
PhysGen Renal A data |
glomerular filtration trait |
male |
87 days-120 days |
3 |
1.49 |
ml/min |
0.16 |
0.28 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms and pups used in studies were fed Teklad |
51955 |
481 |
LEW/Crl |
creatinine clearance |
controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) |
PhysGen Renal A data |
glomerular filtration trait |
male |
87 days-120 days |
4 |
2.35 |
ml/min |
0.29 |
0.57 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
|
52029 |
481 |
SS-Chr 9BN/Mcwi |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
male |
80 days-99 days |
8 |
1.85 |
ml/min |
0.19 |
0.55 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52145 |
482 |
SS.BN-(D12Arb13-D12Rat79)/Mcwi |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
female |
80 days-99 days |
8 |
1.68 |
ml/min |
0.46 |
1.31 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52146 |
482 |
SS-Chr 15BN/Mcwi |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
male |
80 days-99 days |
7 |
2.52 |
ml/min |
0.27 |
0.71 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52159 |
482 |
SS-Chr 13BN/Mcwi |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
female |
80 days-99 days |
18 |
1.39 |
ml/min |
0.09 |
0.38 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52163 |
482 |
SS-Chr 19BN/Mcwi |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
male |
80 days-99 days |
3 |
2.44 |
ml/min |
0.21 |
0.36 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52179 |
482 |
SS-Chr 12BN/Mcwi |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
male |
80 days-99 days |
5 |
2.85 |
ml/min |
0.21 |
0.48 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52180 |
482 |
SDT/Jcl |
creatinine clearance |
nephrectomy then controlled content diet (1.2 %) (for 70 days) then controlled content diet (1 %) (for 70 days) |
Watanabe K, et al., J Atheroscler Thromb. 2017 Jul 1. doi: 10.5551/jat.40170. |
glomerular filtration trait |
male |
140 days
| 6 |
2.7 |
ml/min |
0.3 |
0.73 |
|
urine creatinine analysis |
0.0 |
unx |
84 |
days |
|
|
|
100135 |
2419 |
SDT/Jcl |
creatinine clearance |
nephrectomy then controlled content diet (1.2 %) (for 70 days) then controlled content diet (1 %) (for 70 days) and paricalcitol (0.3 ug/kg) (for 70 days) |
Watanabe K, et al., J Atheroscler Thromb. 2017 Jul 1. doi: 10.5551/jat.40170. |
glomerular filtration trait |
male |
140 days
| 6 |
2.4 |
ml/min |
0.2 |
0.49 |
|
urine creatinine analysis |
0.0 |
unx |
84 |
days |
|
|
|
100139 |
2419 |
SD |
creatinine clearance |
control condition |
Goto M, et al., Pediatr Nephrol. 2010 Dec;25(12):2449-57. doi: 10.1007/s00467-010-1621-z. Epub 2010 Aug 27. |
glomerular filtration trait |
male |
60 days
| 3 |
0.0 |
ml/min |
0.0 |
0.0 |
|
urine creatinine analysis |
0.0 |
|
0 |
|
|
|
|
100210 |
2439 |
WKY/NHsd |
creatinine clearance |
controlled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then sunitinib (7 mg/kg/d) (for 8 days) |
Lankhorst S, et al., Hypertension. 2017 May;69(5):919-926. doi: 10.1161/HYPERTENSIONAHA.116.08565. Epub 2017 Mar 20. |
glomerular filtration trait |
male |
0 days
| 8 |
3.5 |
ml/min |
0.2 |
0.57 |
|
urine creatinine analysis |
0.0 |
|
0 |
|
|
|
|
99182 |
2238 |
SHRSP/A3NCrl |
creatinine clearance |
controlled sodium chloride content drinking water (1 %) (for 91 days) and controlled fat content diet (24.5 %) (for 91 days) then vehicle control condition (for 35 days) |
Lenhard SC, etal., J Pharmacol Exp Ther. 2003 Dec;307(3):939-46. doi: 10.1124/jpet.103.057398. Epub 2003 Oct 15. |
glomerular filtration trait |
male |
161 days-175 days |
6 |
2.0 |
ml/min |
0.2 |
0.49 |
|
urine creatinine analysis |
0.0 |
|
0 |
|
|
|
|
107388 |
3083 |
MWF |
creatinine clearance |
controlled enalapril content drinking water (10 mg/kg) (between 0 and 336 hours) |
Schie?l IM, etal., J Pharmacol Exp Ther. 2015 May;353(2):299-306. doi: 10.1124/jpet.114.222125. Epub 2015 Feb 13. |
glomerular filtration trait |
male |
379 days
| 6 |
3.44 |
ml/min |
0.1 |
0.24 |
|
urine creatinine analysis |
0.0 |
|
0 |
|
|
|
|
108065 |
3113 |
HsdCpb:WU |
creatinine clearance |
left nephrectomy (for 84 days) then controlled ramipril content drinking water (1 mg/kg/d) (for 28 days) |
Rothermund L, etal., Am J Hypertens. 2011 Apr;24(4):474-81. doi: 10.1038/ajh.2010.206. Epub 2010 Sep 23. |
glomerular filtration trait |
not specified |
84 days
| 15 |
1.12 |
ml/min |
0.1 |
0.39 |
|
urine creatinine analysis |
0.0 |
|
0 |
|
|
|
|
109649 |
3149 |
SS-Chr 16BN/Mcwi |
creatinine clearance |
controlled sodium content diet (4 %) (between 17 and 36 days) |
PhysGen Renal A data |
glomerular filtration trait |
male |
87 days-120 days |
10 |
2.35 |
ml/min |
0.14 |
0.44 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms and pups used in studies were fed Dyets |
51802 |
481 |
SS-Chr 6BN/Mcwi |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
female |
80 days-99 days |
7 |
1.3 |
ml/min |
0.1 |
0.28 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52144 |
482 |
SS-Chr 14BN/Mcwi |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
male |
80 days-99 days |
7 |
1.79 |
ml/min |
0.18 |
0.47 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52147 |
482 |
FHH-Chr 12BN/Mcwi |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
male |
80 days-99 days |
10 |
1.33 |
ml/min |
0.14 |
0.44 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52358 |
482 |
FHH-Chr 15BN/Mcwi |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
female |
80 days-99 days |
7 |
2.4 |
ml/min |
0.46 |
1.23 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52361 |
482 |
BN/NHsdMcwi |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
female |
80 days-99 days |
7 |
1.23 |
ml/min |
0.15 |
0.4 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52380 |
482 |
WKY/NHsd |
creatinine clearance |
standard rat chow (for 8 days) then sunitinib (7 mg/kg/d) (for 8 days) |
Lankhorst S, et al., Hypertension. 2017 May;69(5):919-926. doi: 10.1161/HYPERTENSIONAHA.116.08565. Epub 2017 Mar 20. |
glomerular filtration trait |
male |
0 days
| 8 |
3.1 |
ml/min |
0.5 |
1.41 |
|
urine creatinine analysis |
0.0 |
|
0 |
|
|
|
|
99180 |
2238 |
LEW/Crl |
creatinine clearance |
controlled sodium content diet (4 %) (between 17 and 36 days) |
PhysGen Renal A data |
glomerular filtration trait |
female |
87 days-120 days |
6 |
1.17 |
ml/min |
0.1 |
0.25 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
|
50573 |
481 |
LEW/Crl |
creatinine clearance |
controlled sodium content diet (4 %) (between 17 and 36 days) |
PhysGen Renal A data |
glomerular filtration trait |
male |
87 days-120 days |
4 |
1.83 |
ml/min |
0.27 |
0.53 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
|
50574 |
481 |
SS/JrHsdMcwi |
creatinine clearance |
controlled sodium content diet (4 %) (between 17 and 36 days) |
PhysGen Renal A data |
glomerular filtration trait |
male |
87 days-120 days |
14 |
1.64 |
ml/min |
0.17 |
0.64 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms and pups used in studies were fed Teklad |
51944 |
481 |
SS-Chr 20BN/Mcwi |
creatinine clearance |
controlled sodium content diet (4 %) (between 17 and 36 days) |
PhysGen Renal A data |
glomerular filtration trait |
female |
87 days-120 days |
12 |
0.96 |
ml/min |
0.09 |
0.3 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms and pups used in studies were fed Teklad |
51945 |
481 |
GH/OmrMcwi |
creatinine clearance |
controlled sodium content diet (4 %) (between 17 and 36 days) |
PhysGen Renal A data |
glomerular filtration trait |
female |
87 days-120 days |
9 |
1.0 |
ml/min |
0.08 |
0.24 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms and pups used in studies were fed Teklad |
51946 |
481 |
SS-Chr 9BN/Mcwi |
creatinine clearance |
controlled sodium content diet (4 %) (between 17 and 36 days) |
PhysGen Renal A data |
glomerular filtration trait |
male |
87 days-120 days |
13 |
1.13 |
ml/min |
0.2 |
0.73 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms and pups used in studies were fed Teklad |
51948 |
481 |
BN/NHsdMcwi |
creatinine clearance |
controlled sodium content diet (4 %) (between 17 and 36 days) |
PhysGen Renal A data |
glomerular filtration trait |
female |
87 days-120 days |
6 |
1.28 |
ml/min |
0.07 |
0.17 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms and pups used in studies were fed Teklad |
51956 |
481 |
WKY/NCrl |
creatinine clearance |
controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) |
PhysGen Renal A data |
glomerular filtration trait |
male |
87 days-120 days |
9 |
1.5 |
ml/min |
0.15 |
0.45 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
|
52027 |
481 |
WKY/NCrl |
creatinine clearance |
controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) |
PhysGen Renal A data |
glomerular filtration trait |
female |
87 days-120 days |
5 |
0.94 |
ml/min |
0.17 |
0.39 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
|
52030 |
481 |
SS-Chr 14BN/Mcwi |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
female |
80 days-99 days |
9 |
1.62 |
ml/min |
0.21 |
0.64 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52143 |
482 |
SS-Chr 6BN/Mcwi |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
male |
80 days-99 days |
8 |
1.87 |
ml/min |
0.24 |
0.68 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52149 |
482 |
SS-Chr 17BN/Mcwi |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
male |
80 days-99 days |
5 |
2.41 |
ml/min |
0.57 |
1.27 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52151 |
482 |
FHH-Chr 19BN/Mcwi |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
male |
80 days-99 days |
6 |
1.76 |
ml/min |
0.34 |
0.83 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52343 |
482 |
FHH-Chr 2BN/Mcwi |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
female |
80 days-99 days |
5 |
1.71 |
ml/min |
0.2 |
0.44 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52346 |
482 |
FHH-Chr 14BN/Mcwi |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
female |
80 days-99 days |
4 |
1.09 |
ml/min |
0.1 |
0.21 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52347 |
482 |
FHH-Chr 18BN/Mcwi |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
female |
80 days-99 days |
8 |
1.02 |
ml/min |
0.14 |
0.41 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52359 |
482 |
FHH-Chr 3BN/Mcwi |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
male |
80 days-99 days |
3 |
0.68 |
ml/min |
0.25 |
0.44 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52362 |
482 |
FHH-Chr 10BN/Mcwi |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
female |
80 days-99 days |
7 |
1.82 |
ml/min |
0.35 |
0.94 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52366 |
482 |
FHH-Chr 1BN/Mcwi |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
male |
80 days-99 days |
7 |
2.39 |
ml/min |
0.19 |
0.49 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52368 |
482 |
FHH-Chr 17BN/Mcwi |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
female |
80 days-99 days |
11 |
0.76 |
ml/min |
0.11 |
0.37 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52371 |
482 |
FHH-Chr 7BN/Mcwi |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
female |
80 days-99 days |
7 |
1.44 |
ml/min |
0.23 |
0.6 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52377 |
482 |
BN/NHsdMcwi |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
male |
80 days-99 days |
8 |
2.55 |
ml/min |
0.26 |
0.72 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52379 |
482 |
FHH-Chr 9BN/Mcwi |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
male |
80 days-99 days |
4 |
1.64 |
ml/min |
0.13 |
0.25 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52382 |
482 |
SS-Chr 16BN/Mcwi |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
male |
80 days-99 days |
8 |
2.25 |
ml/min |
0.21 |
0.6 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52162 |
482 |
SS-Chr 20BN/Mcwi |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
male |
80 days-99 days |
7 |
2.03 |
ml/min |
0.27 |
0.71 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52165 |
482 |
SS/JrHsdMcwi |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
female |
80 days-99 days |
9 |
1.7 |
ml/min |
0.13 |
0.39 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52177 |
482 |
SS-Chr 12BN/Mcwi |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
female |
80 days-99 days |
3 |
2.21 |
ml/min |
0.03 |
0.06 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52185 |
482 |
SS-Chr XBN/Mcwi |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
male |
80 days-99 days |
3 |
2.43 |
ml/min |
0.72 |
1.25 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52188 |
482 |
BN/NHsdMcwi |
creatinine clearance |
controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) |
Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. |
glomerular filtration trait |
female |
90 days-94 days |
10 |
1.7 |
ml/min |
0.2 |
0.63 |
|
urine creatinine analysis |
0.0 |
|
0 |
|
plasma creatinine analysis |
|
|
67283 |
151 |
Crl:CD(SD) |
creatinine clearance |
controlled sodium content diet (4 %) (between 17 and 36 days) |
PhysGen Renal A data |
glomerular filtration trait |
male |
87 days-120 days |
6 |
2.0 |
ml/min |
0.19 |
0.48 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan |
51683 |
481 |
F344/DuCrl |
creatinine clearance |
controlled sodium content diet (4 %) (between 17 and 36 days) |
PhysGen Renal A data |
glomerular filtration trait |
female |
87 days-120 days |
9 |
1.22 |
ml/min |
0.12 |
0.37 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan |
51686 |
481 |
SS/JrHsdMcwi |
creatinine clearance |
controlled sodium content diet (4 %) (between 17 and 36 days) |
PhysGen Renal A data |
glomerular filtration trait |
male |
87 days-120 days |
14 |
1.94 |
ml/min |
0.2 |
0.73 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms and pups used in studies were fed Dyets |
51797 |
481 |
FHH/EurMcwi |
creatinine clearance |
controlled sodium content diet (4 %) (between 17 and 36 days) |
PhysGen Renal A data |
glomerular filtration trait |
female |
87 days-120 days |
7 |
1.45 |
ml/min |
0.13 |
0.33 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms and pups used in studies were fed Dyets |
51798 |
481 |
SHR/NCrl |
creatinine clearance |
controlled sodium content diet (4 %) (between 17 and 36 days) |
PhysGen Renal A data |
glomerular filtration trait |
male |
87 days-120 days |
6 |
1.53 |
ml/min |
0.06 |
0.16 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms and pups used in studies were fed Dyets |
51806 |
481 |
SHR/NCrl |
creatinine clearance |
controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) |
PhysGen Renal A data |
glomerular filtration trait |
male |
87 days-120 days |
5 |
1.42 |
ml/min |
0.18 |
0.41 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms and pups used in studies were fed Dyets |
51550 |
481 |
SS/JrHsdMcwi |
creatinine clearance |
controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) |
PhysGen Renal A data |
glomerular filtration trait |
male |
87 days-120 days |
12 |
1.26 |
ml/min |
0.24 |
0.84 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms and pups used in studies were fed Teklad |
51052 |
481 |
SD |
creatinine clearance |
nephrectomy then controlled content diet (1.2 %) (for 70 days) then controlled content diet (1 %) (for 70 days) and paricalcitol (0.3 ug/kg) (for 70 days) |
Watanabe K, et al., J Atheroscler Thromb. 2017 Jul 1. doi: 10.5551/jat.40170. |
glomerular filtration trait |
male |
140 days
| 6 |
2.3 |
ml/min |
0.3 |
0.73 |
|
urine creatinine analysis |
0.0 |
unx |
84 |
days |
|
|
|
100140 |
2419 |
WKY/NHsd |
creatinine clearance |
standard rat chow (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) |
Lankhorst S, et al., Hypertension. 2017 May;69(5):919-926. doi: 10.1161/HYPERTENSIONAHA.116.08565. Epub 2017 Mar 20. |
glomerular filtration trait |
male |
0 days
| 7 |
3.1 |
ml/min |
0.5 |
1.32 |
|
urine creatinine analysis |
0.0 |
|
0 |
|
|
|
|
99179 |
2238 |
SD |
creatinine clearance |
control condition |
Goto M, et al., Pediatr Nephrol. 2010 Dec;25(12):2449-57. doi: 10.1007/s00467-010-1621-z. Epub 2010 Aug 27. |
glomerular filtration trait |
male |
120 days
| 3 |
0.0 |
ml/min |
0.0 |
0.0 |
|
urine creatinine analysis |
0.0 |
|
0 |
|
|
|
|
100212 |
2439 |
Hsd:WI |
creatinine clearance |
control condition |
Rothermund L, etal., J Hypertens. 2006 Sep 24(9). |
glomerular filtration trait |
not specified |
100 days
| 0 |
2.36 |
ml/min |
0.14 |
|
|
urine creatinine analysis |
0.0 |
|
0 |
|
|
|
|
108106 |
3115 |
MWF |
creatinine clearance |
control condition |
Schie?l IM, etal., J Pharmacol Exp Ther. 2015 May;353(2):299-306. doi: 10.1124/jpet.114.222125. Epub 2015 Feb 13. |
glomerular filtration trait |
male |
365 days
| 6 |
1.64 |
ml/min |
0.3 |
0.73 |
|
urine creatinine analysis |
0.0 |
|
0 |
|
|
|
|
108064 |
3113 |
HsdCpb:WU |
creatinine clearance |
left nephrectomy (for 84 days) |
Rothermund L, etal., Am J Hypertens. 2011 Apr;24(4):474-81. doi: 10.1038/ajh.2010.206. Epub 2010 Sep 23. |
glomerular filtration trait |
not specified |
84 days
| 15 |
0.47 |
ml/min |
0.06 |
0.23 |
|
urine creatinine analysis |
0.0 |
|
0 |
|
|
|
|
109647 |
3149 |
SS-Chr 20BN/Mcwi |
creatinine clearance |
controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) |
PhysGen Renal A data |
glomerular filtration trait |
female |
87 days-120 days |
10 |
1.13 |
ml/min |
0.15 |
0.46 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms and pups used in studies were fed Teklad |
51053 |
481 |
SS-Chr 18BN/Mcwi |
creatinine clearance |
controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) |
PhysGen Renal A data |
glomerular filtration trait |
male |
87 days-120 days |
4 |
1.66 |
ml/min |
0.1 |
0.2 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks |
51447 |
481 |
SS/JrHsdMcwi |
creatinine clearance |
controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) |
PhysGen Renal A data |
glomerular filtration trait |
female |
87 days-120 days |
8 |
1.36 |
ml/min |
0.12 |
0.35 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms and pups used in studies were fed Dyets |
51549 |
481 |
Crl:CD(SD) |
creatinine clearance |
controlled sodium content diet (4 %) (between 17 and 36 days) |
PhysGen Renal A data |
glomerular filtration trait |
female |
87 days-120 days |
5 |
1.19 |
ml/min |
0.22 |
0.48 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan |
51685 |
481 |
GH/OmrMcwi |
creatinine clearance |
controlled sodium content diet (4 %) (between 17 and 36 days) |
PhysGen Renal A data |
glomerular filtration trait |
male |
87 days-120 days |
8 |
2.38 |
ml/min |
0.13 |
0.38 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms and pups used in studies were fed Dyets |
51807 |
481 |
LEW/Crl |
creatinine clearance |
controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) |
PhysGen Renal A data |
glomerular filtration trait |
female |
87 days-120 days |
5 |
1.64 |
ml/min |
0.16 |
0.36 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
|
52028 |
481 |
SS.BN-(D12Arb13-D12Rat79)/Mcwi |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
male |
80 days-99 days |
9 |
1.96 |
ml/min |
0.15 |
0.44 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52142 |
482 |
SS-Chr 16BN/Mcwi |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
female |
80 days-99 days |
9 |
1.15 |
ml/min |
0.17 |
0.51 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52158 |
482 |
FHH-Chr 6BN/Mcwi |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
female |
80 days-99 days |
5 |
1.28 |
ml/min |
0.12 |
0.27 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52350 |
482 |
SS-Chr 3BN/Mcwi |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
female |
80 days-99 days |
5 |
1.84 |
ml/min |
0.2 |
0.46 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52164 |
482 |
SS-Chr 18BN/Mcwi |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
male |
80 days-99 days |
8 |
1.75 |
ml/min |
0.2 |
0.58 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52170 |
482 |
FHH-Chr 12BN/Mcwi |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
female |
80 days-99 days |
7 |
1.1 |
ml/min |
0.19 |
0.5 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52339 |
482 |
FHH-Chr 7BN/Mcwi |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
male |
80 days-99 days |
8 |
1.24 |
ml/min |
0.29 |
0.81 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52383 |
482 |
PCK-Pkhd1pck/CrljCrl |
creatinine clearance |
control condition |
Goto M, et al., Pediatr Nephrol. 2010 Dec;25(12):2449-57. doi: 10.1007/s00467-010-1621-z. Epub 2010 Aug 27. |
glomerular filtration trait |
male |
180 days
| 4 |
0.0 |
ml/min |
0.0 |
0.0 |
|
urine creatinine analysis |
0.0 |
|
0 |
|
|
|
|
100213 |
2439 |
SS-Chr 18BN/Mcwi |
creatinine clearance |
controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) |
PhysGen Renal A data |
glomerular filtration trait |
male |
87 days-120 days |
6 |
1.92 |
ml/min |
0.12 |
0.28 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms and pups used in studies were fed Dyets |
51540 |
481 |
FHH/EurMcwi |
creatinine clearance |
controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) |
PhysGen Renal A data |
glomerular filtration trait |
female |
87 days-120 days |
7 |
1.45 |
ml/min |
0.17 |
0.46 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms and pups used in studies were fed Dyets |
51542 |
481 |
SHR/NCrl |
creatinine clearance |
controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) |
PhysGen Renal A data |
glomerular filtration trait |
female |
87 days-120 days |
7 |
1.08 |
ml/min |
0.08 |
0.2 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms and pups used in studies were fed Dyets |
51544 |
481 |
GH/OmrMcwi |
creatinine clearance |
controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) |
PhysGen Renal A data |
glomerular filtration trait |
female |
87 days-120 days |
3 |
1.69 |
ml/min |
0.06 |
0.1 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms and pups used in studies were fed Dyets |
51545 |
481 |
GH/OmrMcwi |
creatinine clearance |
controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) |
PhysGen Renal A data |
glomerular filtration trait |
male |
87 days-120 days |
8 |
2.13 |
ml/min |
0.12 |
0.33 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms and pups used in studies were fed Dyets |
51551 |
481 |
FHH/EurMcwi |
creatinine clearance |
controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) |
PhysGen Renal A data |
glomerular filtration trait |
female |
87 days-120 days |
6 |
1.5 |
ml/min |
0.12 |
0.3 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks |
51449 |
481 |
GH/OmrMcwi |
creatinine clearance |
controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) |
PhysGen Renal A data |
glomerular filtration trait |
male |
87 days-120 days |
8 |
1.29 |
ml/min |
0.23 |
0.66 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms and pups used in studies were fed Teklad |
51058 |
481 |
SS-Chr 20BN/Mcwi |
creatinine clearance |
controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) |
PhysGen Renal A data |
glomerular filtration trait |
male |
87 days-120 days |
10 |
1.2 |
ml/min |
0.12 |
0.38 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms and pups used in studies were fed Teklad |
51061 |
481 |
F344/DuCrl |
creatinine clearance |
controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) |
PhysGen Renal A data |
glomerular filtration trait |
male |
87 days-120 days |
5 |
1.04 |
ml/min |
0.2 |
0.44 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan |
51257 |
481 |
Crl:CD(SD) |
creatinine clearance |
controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) |
PhysGen Renal A data |
glomerular filtration trait |
female |
87 days-120 days |
3 |
1.5 |
ml/min |
0.2 |
0.34 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan |
51258 |
481 |
Hsd:SD |
creatinine clearance |
controlled sodium content diet (4 %) (between 17 and 36 days) |
PhysGen Renal A data |
glomerular filtration trait |
female |
87 days-120 days |
15 |
1.81 |
ml/min |
0.13 |
0.51 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan |
51748 |
481 |
BN/NHsdMcwi |
creatinine clearance |
controlled sodium content diet (4 %) (between 17 and 36 days) |
PhysGen Renal A data |
glomerular filtration trait |
female |
87 days-120 days |
2 |
1.65 |
ml/min |
0.23 |
0.32 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms and pups used in studies were fed Dyets |
51804 |
481 |
FHH/EurMcwi |
creatinine clearance |
controlled sodium content diet (4 %) (between 17 and 36 days) |
PhysGen Renal A data |
glomerular filtration trait |
female |
87 days-120 days |
7 |
1.61 |
ml/min |
0.15 |
0.38 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks |
51932 |
481 |
FHH/EurMcwi |
creatinine clearance |
controlled sodium content diet (4 %) (between 17 and 36 days) |
PhysGen Renal A data |
glomerular filtration trait |
female |
87 days-120 days |
5 |
1.27 |
ml/min |
0.15 |
0.33 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms and pups used in studies were fed Teklad |
51943 |
481 |
SHR/NCrl |
creatinine clearance |
controlled sodium content diet (4 %) (between 17 and 36 days) |
PhysGen Renal A data |
glomerular filtration trait |
male |
87 days-120 days |
6 |
1.2 |
ml/min |
0.09 |
0.22 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms and pups used in studies were fed Teklad |
51949 |
481 |
SS-Chr 9BN/Mcwi |
creatinine clearance |
controlled sodium content diet (4 %) (between 17 and 36 days) |
PhysGen Renal A data |
glomerular filtration trait |
female |
87 days-120 days |
14 |
0.77 |
ml/min |
0.16 |
0.61 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms and pups used in studies were fed Teklad |
51951 |
481 |
FHH/EurMcwi |
creatinine clearance |
controlled sodium content diet (4 %) (between 17 and 36 days) |
PhysGen Renal A data |
glomerular filtration trait |
male |
87 days-120 days |
5 |
1.86 |
ml/min |
0.28 |
0.63 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms and pups used in studies were fed Teklad |
51954 |
481 |
SS-Chr 11BN/Mcwi |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
female |
80 days-99 days |
11 |
1.7 |
ml/min |
0.22 |
0.74 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52166 |
482 |
SS-Chr 11BN/Mcwi |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
male |
80 days-99 days |
14 |
2.51 |
ml/min |
0.24 |
0.9 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52168 |
482 |
SS/JrHsdMcwi |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
male |
80 days-99 days |
53 |
2.17 |
ml/min |
0.11 |
0.8 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52171 |
482 |
SS-Chr XBN/Mcwi |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
female |
80 days-99 days |
3 |
1.6 |
ml/min |
0.34 |
0.59 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52173 |
482 |
SS.BN-(D8Rat163-D8Rat81)/Mcwi |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
male |
80 days-99 days |
18 |
2.08 |
ml/min |
0.15 |
0.64 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52184 |
482 |
BN/NHsdMcwi |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
female |
80 days-99 days |
15 |
1.13 |
ml/min |
0.14 |
0.55 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52187 |
482 |
FHH-Chr 19BN/Mcwi |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
female |
80 days-99 days |
7 |
1.94 |
ml/min |
0.27 |
0.72 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52349 |
482 |
FHH-Chr 5BN/Mcwi |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
male |
80 days-99 days |
7 |
1.6 |
ml/min |
0.12 |
0.32 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52351 |
482 |
FHH-Chr 8BN/Mcwi |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
male |
80 days-99 days |
3 |
1.88 |
ml/min |
0.43 |
0.75 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52352 |
482 |
FHH-Chr 20BN/Mcwi |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
female |
80 days-99 days |
6 |
2.06 |
ml/min |
0.39 |
0.95 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52357 |
482 |
FHH-Chr 11BN/Mcwi |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
male |
80 days-99 days |
3 |
1.71 |
ml/min |
0.15 |
0.27 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52373 |
482 |
FHH-Chr 16BN/Mcwi |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
male |
80 days-99 days |
7 |
1.55 |
ml/min |
0.35 |
0.92 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52384 |
482 |
FHH-Chr 1BN/Mcwi |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
female |
80 days-99 days |
9 |
1.3 |
ml/min |
0.18 |
0.54 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52385 |
482 |
SS-Chr 9BN/Mcwi |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
female |
80 days-99 days |
8 |
1.12 |
ml/min |
0.13 |
0.36 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52148 |
482 |
SS-Chr 5BN/Mcwi |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
female |
80 days-99 days |
7 |
1.96 |
ml/min |
0.13 |
0.33 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52154 |
482 |
SS |
creatinine clearance |
controlled sodium chloride content diet (8 %) (for 42 days) |
Wu F, et al., Int J Hypertens. 2016;2016:9146870. doi: 10.1155/2016/9146870. Epub 2016 Dec 19. |
glomerular filtration trait |
male |
91 days
| 8 |
2.8 |
ml/min |
0.07 |
0.2 |
|
urine creatinine analysis |
0.0 |
|
0 |
|
|
|
|
102288 |
2683 |
SR/Hsd |
creatinine clearance |
controlled sodium chloride content diet (8 %) (for 42 days) |
Wu F, et al., Int J Hypertens. 2016;2016:9146870. doi: 10.1155/2016/9146870. Epub 2016 Dec 19. |
glomerular filtration trait |
male |
91 days
| 8 |
6.1 |
ml/min |
0.28 |
0.8 |
|
urine creatinine analysis |
0.0 |
|
0 |
|
|
|
|
102289 |
2683 |
Hsd:WI |
creatinine clearance |
control condition |
Rothermund L, etal., J Hypertens. 2006 Sep 24(9). |
glomerular filtration trait |
not specified |
100 days
| 0 |
2.76 |
ml/min |
0.17 |
|
|
urine creatinine analysis |
0.0 |
|
0 |
|
|
|
|
108105 |
3115 |
MWF/FubRkb |
creatinine clearance |
left nephrectomy (for 84 days) |
Rothermund L, etal., Am J Hypertens. 2011 Apr;24(4):474-81. doi: 10.1038/ajh.2010.206. Epub 2010 Sep 23. |
glomerular filtration trait |
not specified |
84 days
| 15 |
0.57 |
ml/min |
0.07 |
0.27 |
|
urine creatinine analysis |
0.0 |
|
0 |
|
|
|
|
109648 |
3149 |
MWF/FubRkb |
creatinine clearance |
left nephrectomy (for 84 days) then controlled ramipril content drinking water (1 mg/kg/d) (for 28 days) |
Rothermund L, etal., Am J Hypertens. 2011 Apr;24(4):474-81. doi: 10.1038/ajh.2010.206. Epub 2010 Sep 23. |
glomerular filtration trait |
not specified |
84 days
| 15 |
0.92 |
ml/min |
0.05 |
0.19 |
|
urine creatinine analysis |
0.0 |
|
0 |
|
|
|
|
109650 |
3149 |
SS-Chr 9BN/Mcwi |
creatinine clearance |
controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) |
PhysGen Renal A data |
glomerular filtration trait |
female |
87 days-120 days |
12 |
0.56 |
ml/min |
0.15 |
0.53 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms and pups used in studies were fed Teklad |
51059 |
481 |
FHH/EurMcwi |
creatinine clearance |
controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) |
PhysGen Renal A data |
glomerular filtration trait |
male |
87 days-120 days |
4 |
1.21 |
ml/min |
0.21 |
0.42 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms and pups used in studies were fed Teklad |
51062 |
481 |
SS-Chr 16BN/Mcwi |
creatinine clearance |
controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) |
PhysGen Renal A data |
glomerular filtration trait |
female |
87 days-120 days |
5 |
1.27 |
ml/min |
0.09 |
0.19 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms and pups used in studies were fed Dyets |
51543 |
481 |
SS-Chr 16BN/Mcwi |
creatinine clearance |
controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) |
PhysGen Renal A data |
glomerular filtration trait |
male |
87 days-120 days |
7 |
1.93 |
ml/min |
0.1 |
0.27 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms and pups used in studies were fed Dyets |
51546 |
481 |
SS/JrHsdMcwi |
creatinine clearance |
controlled sodium content diet (4 %) (between 17 and 36 days) |
PhysGen Renal A data |
glomerular filtration trait |
female |
87 days-120 days |
6 |
1.67 |
ml/min |
0.22 |
0.55 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms and pups used in studies were fed Dyets |
51805 |
481 |
SS.BN-(D8Rat163-D8Rat81)/Mcwi |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
female |
80 days-99 days |
10 |
1.53 |
ml/min |
0.14 |
0.43 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52178 |
482 |
SS-Chr 19BN/Mcwi |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
female |
80 days-99 days |
7 |
1.05 |
ml/min |
0.32 |
0.85 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52181 |
482 |
SS-Chr 2BN/Mcwi |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
male |
80 days-99 days |
9 |
2.27 |
ml/min |
0.15 |
0.46 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52189 |
482 |
FHH-Chr 5BN/Mcwi |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
female |
80 days-99 days |
5 |
1.71 |
ml/min |
0.18 |
0.41 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52345 |
482 |
FHH-Chr 6BN/Mcwi |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
male |
80 days-99 days |
9 |
1.69 |
ml/min |
0.15 |
0.46 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52348 |
482 |
FHH-Chr 18BN/Mcwi |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
male |
80 days-99 days |
7 |
1.07 |
ml/min |
0.15 |
0.39 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52356 |
482 |
FHH-Chr 16BN/Mcwi |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
female |
80 days-99 days |
6 |
0.81 |
ml/min |
0.12 |
0.29 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52367 |
482 |
FHH-Chr 4BN/Mcwi |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
male |
80 days-99 days |
5 |
0.98 |
ml/min |
0.12 |
0.26 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52369 |
482 |
FHH-Chr 11BN/Mcwi |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
female |
80 days-99 days |
5 |
1.06 |
ml/min |
0.21 |
0.48 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52375 |
482 |
MWF/FubRkb |
creatinine clearance |
sham surgical control condition (for 84 days) |
Rothermund L, etal., Am J Hypertens. 2011 Apr;24(4):474-81. doi: 10.1038/ajh.2010.206. Epub 2010 Sep 23. |
glomerular filtration trait |
not specified |
84 days
| 15 |
2.36 |
ml/min |
0.14 |
0.54 |
|
urine creatinine analysis |
0.0 |
|
0 |
|
|
|
|
109646 |
3149 |
FHH/EurMcwi |
creatinine clearance |
controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) |
PhysGen Renal A data |
glomerular filtration trait |
female |
87 days-120 days |
5 |
1.14 |
ml/min |
0.11 |
0.24 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms and pups used in studies were fed Teklad |
51051 |
481 |
GH/OmrMcwi |
creatinine clearance |
controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) |
PhysGen Renal A data |
glomerular filtration trait |
female |
87 days-120 days |
9 |
0.71 |
ml/min |
0.07 |
0.2 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms and pups used in studies were fed Teklad |
51054 |
481 |
Hsd:SD |
creatinine clearance |
controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) |
PhysGen Renal A data |
glomerular filtration trait |
female |
87 days-120 days |
13 |
1.09 |
ml/min |
0.1 |
0.37 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan |
51403 |
481 |
SS/JrHsdMcwi |
creatinine clearance |
controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) |
PhysGen Renal A data |
glomerular filtration trait |
male |
87 days-120 days |
4 |
1.51 |
ml/min |
0.23 |
0.45 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks |
51448 |
481 |
FHH/EurMcwi |
creatinine clearance |
controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) |
PhysGen Renal A data |
glomerular filtration trait |
male |
87 days-120 days |
9 |
2.23 |
ml/min |
0.08 |
0.25 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms and pups used in studies were fed Dyets |
51547 |
481 |
F344/DuCrl |
creatinine clearance |
controlled sodium content diet (4 %) (between 17 and 36 days) |
PhysGen Renal A data |
glomerular filtration trait |
male |
87 days-120 days |
7 |
1.34 |
ml/min |
0.23 |
0.62 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan |
51684 |
481 |
GH/OmrMcwi |
creatinine clearance |
controlled sodium content diet (4 %) (between 17 and 36 days) |
PhysGen Renal A data |
glomerular filtration trait |
female |
87 days-120 days |
3 |
1.73 |
ml/min |
0.18 |
0.32 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms and pups used in studies were fed Dyets |
51801 |
481 |
SS-Chr 17BN/Mcwi |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
female |
80 days-99 days |
5 |
3.45 |
ml/min |
1.21 |
2.69 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52153 |
482 |
SS-Chr 5BN/Mcwi |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
male |
80 days-99 days |
6 |
2.69 |
ml/min |
0.11 |
0.28 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52156 |
482 |
SS-Chr 20BN/Mcwi |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
female |
80 days-99 days |
8 |
1.39 |
ml/min |
0.14 |
0.4 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52157 |
482 |
SS-Chr 15BN/Mcwi |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
female |
80 days-99 days |
3 |
1.78 |
ml/min |
0.21 |
0.37 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52160 |
482 |
WKY/NCrl |
creatinine clearance |
controlled sodium content diet (4 %) (between 17 and 36 days) |
PhysGen Renal A data |
glomerular filtration trait |
female |
87 days-120 days |
6 |
1.14 |
ml/min |
0.14 |
0.34 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
|
50575 |
481 |
SS-Chr YBN/Mcwi |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
male |
80 days-99 days |
12 |
2.76 |
ml/min |
0.28 |
0.96 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52169 |
482 |
SS-Chr 4BN/Mcwi |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
female |
80 days-99 days |
7 |
0.09 |
ml/min |
0.01 |
0.04 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52182 |
482 |
SS/JrHsdMcwi |
creatinine clearance |
controlled sodium content diet (4 %) (between 17 and 36 days) |
PhysGen Renal A data |
glomerular filtration trait |
male |
87 days-120 days |
5 |
1.67 |
ml/min |
0.2 |
0.45 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks |
51931 |
481 |
SS-Chr 16BN/Mcwi |
creatinine clearance |
controlled sodium content diet (4 %) (between 17 and 36 days) |
PhysGen Renal A data |
glomerular filtration trait |
female |
87 days-120 days |
4 |
1.44 |
ml/min |
0.11 |
0.22 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks |
51933 |
481 |
SS-Chr 16BN/Mcwi |
creatinine clearance |
controlled sodium content diet (4 %) (between 17 and 36 days) |
PhysGen Renal A data |
glomerular filtration trait |
male |
87 days-120 days |
6 |
2.03 |
ml/min |
0.15 |
0.38 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks |
51935 |
481 |
SS-Chr 18BN/Mcwi |
creatinine clearance |
controlled sodium content diet (4 %) (between 17 and 36 days) |
PhysGen Renal A data |
glomerular filtration trait |
female |
87 days-120 days |
5 |
1.39 |
ml/min |
0.1 |
0.23 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms and pups used in studies were fed Teklad |
51947 |
481 |
LE/BluGill |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
female |
80 days-99 days |
9 |
2.14 |
ml/min |
0.15 |
0.45 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan |
52290 |
482 |
FHH-Chr 15BN/Mcwi |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
male |
80 days-99 days |
9 |
2.36 |
ml/min |
0.15 |
0.46 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52340 |
482 |
FHH-Chr 20BN/Mcwi |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
male |
80 days-99 days |
7 |
2.81 |
ml/min |
0.46 |
1.22 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52354 |
482 |
FHH-Chr 13BN/Mcwi |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
male |
80 days-99 days |
10 |
1.17 |
ml/min |
0.23 |
0.73 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52355 |
482 |
FHH-Chr XBN/Mcwi |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
male |
80 days-99 days |
6 |
1.27 |
ml/min |
0.24 |
0.59 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52374 |
482 |
FHH-Chr XBN/Mcwi |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
female |
80 days-99 days |
4 |
0.96 |
ml/min |
0.2 |
0.4 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52381 |
482 |
BN/NHsdMcwi |
creatinine clearance |
controlled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) |
Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. |
glomerular filtration trait |
female |
92 days-94 days |
8 |
1.1 |
ml/min |
0.2 |
0.57 |
|
urine creatinine analysis |
0.0 |
|
0 |
|
|
mg/min |
|
69479 |
151 |
SDT/Jcl |
creatinine clearance |
controlled content diet (1.2 %) (for 70 days) then controlled content diet (1 %) (for 70 days) |
Watanabe K, et al., J Atheroscler Thromb. 2017 Jul 1. doi: 10.5551/jat.40170. |
glomerular filtration trait |
male |
140 days
| 6 |
4.5 |
ml/min |
0.5 |
1.22 |
|
urine creatinine analysis |
0.0 |
x |
0 |
days |
|
|
|
100133 |
2419 |
SD |
creatinine clearance |
controlled content diet (1.2 %) (for 70 days) then controlled content diet (1 %) (for 70 days) |
Watanabe K, et al., J Atheroscler Thromb. 2017 Jul 1. doi: 10.5551/jat.40170. |
glomerular filtration trait |
male |
140 days
| 6 |
5.2 |
ml/min |
0.4 |
0.98 |
|
urine creatinine analysis |
0.0 |
x |
0 |
days |
|
|
|
100134 |
2419 |
SD |
creatinine clearance |
nephrectomy then controlled content diet (1.2 %) (for 70 days) then controlled content diet (1 %) (for 70 days) and paricalcitol (0.1 ug/kg) (for 70 days) |
Watanabe K, et al., J Atheroscler Thromb. 2017 Jul 1. doi: 10.5551/jat.40170. |
glomerular filtration trait |
male |
140 days
| 8 |
2.3 |
ml/min |
0.3 |
0.85 |
|
urine creatinine analysis |
0.0 |
unx |
84 |
days |
|
|
|
100138 |
2419 |
SS |
creatinine clearance |
standard diet |
Wu F, et al., Int J Hypertens. 2016;2016:9146870. doi: 10.1155/2016/9146870. Epub 2016 Dec 19. |
glomerular filtration trait |
male |
49 days
| 8 |
4.2 |
ml/min |
0.25 |
0.7 |
|
urine creatinine analysis |
0.0 |
|
0 |
|
|
|
|
102286 |
2683 |
SHRSP/A3NCrl |
creatinine clearance |
control condition (for 91 days) |
Lenhard SC, etal., J Pharmacol Exp Ther. 2003 Dec;307(3):939-46. doi: 10.1124/jpet.103.057398. Epub 2003 Oct 15. |
glomerular filtration trait |
male |
161 days-175 days |
7 |
2.4 |
ml/min |
0.1 |
0.26 |
|
urine creatinine analysis |
0.0 |
|
0 |
|
|
|
|
107387 |
3083 |
HsdCpb:WU |
creatinine clearance |
sham surgical control condition (for 84 days) |
Rothermund L, etal., Am J Hypertens. 2011 Apr;24(4):474-81. doi: 10.1038/ajh.2010.206. Epub 2010 Sep 23. |
glomerular filtration trait |
not specified |
84 days
| 15 |
2.76 |
ml/min |
0.17 |
0.66 |
|
urine creatinine analysis |
0.0 |
|
0 |
|
|
|
|
109645 |
3149 |
SD |
creatinine clearance |
control condition |
Goto M, et al., Pediatr Nephrol. 2010 Dec;25(12):2449-57. doi: 10.1007/s00467-010-1621-z. Epub 2010 Aug 27. |
glomerular filtration trait |
male |
180 days
| 5 |
0.0 |
ml/min |
0.0 |
0.0 |
|
urine creatinine analysis |
0.0 |
|
0 |
|
|
|
|
100214 |
2439 |
PCK-Pkhd1pck/CrljCrl |
creatinine clearance |
control condition |
Goto M, et al., Pediatr Nephrol. 2010 Dec;25(12):2449-57. doi: 10.1007/s00467-010-1621-z. Epub 2010 Aug 27. |
glomerular filtration trait |
male |
120 days
| 3 |
0.0 |
ml/min |
0.0 |
0.0 |
|
urine creatinine analysis |
0.0 |
|
0 |
|
|
|
|
100211 |
2439 |
SS-Chr 9BN/Mcwi |
creatinine clearance |
controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) |
PhysGen Renal A data |
glomerular filtration trait |
male |
87 days-120 days |
12 |
0.79 |
ml/min |
0.17 |
0.6 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms and pups used in studies were fed Teklad |
51056 |
481 |
Hsd:SD |
creatinine clearance |
controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) |
PhysGen Renal A data |
glomerular filtration trait |
male |
87 days-120 days |
9 |
1.85 |
ml/min |
0.15 |
0.44 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan |
51402 |
481 |
SS-Chr 16BN/Mcwi |
creatinine clearance |
controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) |
PhysGen Renal A data |
glomerular filtration trait |
female |
87 days-120 days |
4 |
1.14 |
ml/min |
0.06 |
0.13 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks |
51450 |
481 |
FHH/EurMcwi |
creatinine clearance |
controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) |
PhysGen Renal A data |
glomerular filtration trait |
male |
87 days-120 days |
4 |
1.77 |
ml/min |
0.13 |
0.26 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks |
51453 |
481 |
Crl:CD(SD) |
creatinine clearance |
controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) |
PhysGen Renal A data |
glomerular filtration trait |
male |
87 days-120 days |
6 |
2.46 |
ml/min |
0.22 |
0.54 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan |
51256 |
481 |
F344/DuCrl |
creatinine clearance |
controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) |
PhysGen Renal A data |
glomerular filtration trait |
female |
87 days-120 days |
8 |
0.92 |
ml/min |
0.08 |
0.22 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan |
51259 |
481 |
SS-Chr 7BN/Mcwi |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
male |
80 days-99 days |
9 |
2.08 |
ml/min |
0.16 |
0.48 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52152 |
482 |
SS-Chr 7BN/Mcwi |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
female |
80 days-99 days |
11 |
1.76 |
ml/min |
0.1 |
0.34 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52155 |
482 |
SS-Chr 2BN/Mcwi |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
female |
80 days-99 days |
10 |
1.53 |
ml/min |
0.14 |
0.44 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52183 |
482 |
BN/NHsdMcwi |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
male |
80 days-99 days |
8 |
1.74 |
ml/min |
0.15 |
0.44 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52186 |
482 |
FHH/EurMcwi |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
female |
80 days-99 days |
12 |
1.47 |
ml/min |
0.25 |
0.85 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52342 |
482 |
FHH-Chr YBN/Mcwi |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
male |
80 days-99 days |
4 |
1.34 |
ml/min |
0.09 |
0.18 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52364 |
482 |
FHH/EurMcwi |
creatinine clearance |
controlled sodium content diet (4 %) (between 17 and 36 days) |
PhysGen Renal A data |
glomerular filtration trait |
male |
87 days-120 days |
8 |
1.77 |
ml/min |
0.16 |
0.45 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms and pups used in studies were fed Dyets |
51803 |
481 |
Hsd:SD |
creatinine clearance |
controlled sodium content diet (4 %) (between 17 and 36 days) |
PhysGen Renal A data |
glomerular filtration trait |
male |
87 days-120 days |
11 |
2.61 |
ml/min |
0.23 |
0.77 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan |
51747 |
481 |
SS-Chr 16BN/Mcwi |
creatinine clearance |
controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) |
PhysGen Renal A data |
glomerular filtration trait |
male |
87 days-120 days |
5 |
1.54 |
ml/min |
0.24 |
0.55 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks |
51452 |
481 |
SHR/NCrl |
creatinine clearance |
controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) |
PhysGen Renal A data |
glomerular filtration trait |
male |
87 days-120 days |
5 |
0.83 |
ml/min |
0.17 |
0.38 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms and pups used in studies were fed Teklad |
51057 |
481 |
BN/NHsdMcwi |
creatinine clearance |
controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) |
PhysGen Renal A data |
glomerular filtration trait |
female |
87 days-120 days |
3 |
0.8 |
ml/min |
0.26 |
0.45 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms and pups used in studies were fed Teklad |
51064 |
481 |
BN/NHsdMcwi |
creatinine clearance |
controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) |
PhysGen Renal A data |
glomerular filtration trait |
female |
87 days-120 days |
2 |
1.55 |
ml/min |
0.17 |
0.24 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms and pups used in studies were fed Dyets |
51548 |
481 |
SS-Chr 18BN/Mcwi |
creatinine clearance |
controlled sodium content diet (4 %) (between 17 and 36 days) |
PhysGen Renal A data |
glomerular filtration trait |
male |
87 days-120 days |
6 |
1.5 |
ml/min |
0.11 |
0.27 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks |
51930 |
481 |
SS-Chr 18BN/Mcwi |
creatinine clearance |
controlled sodium content diet (4 %) (between 17 and 36 days) |
PhysGen Renal A data |
glomerular filtration trait |
female |
87 days-120 days |
1 |
1.05 |
ml/min |
|
|
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks |
51934 |
481 |
GH/OmrMcwi |
creatinine clearance |
controlled sodium content diet (4 %) (between 17 and 36 days) |
PhysGen Renal A data |
glomerular filtration trait |
male |
87 days-120 days |
8 |
1.35 |
ml/min |
0.12 |
0.34 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms and pups used in studies were fed Teklad |
51950 |
481 |
WKY/NCrl |
creatinine clearance |
controlled sodium content diet (4 %) (between 17 and 36 days) |
PhysGen Renal A data |
glomerular filtration trait |
male |
87 days-120 days |
9 |
1.54 |
ml/min |
0.09 |
0.27 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
|
50572 |
481 |
SS-Chr 18BN/Mcwi |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
female |
80 days-99 days |
8 |
1.26 |
ml/min |
0.18 |
0.5 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52174 |
482 |
SS-Chr 4BN/Mcwi |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
male |
80 days-99 days |
7 |
0.11 |
ml/min |
0.01 |
0.03 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52176 |
482 |
SS-Chr 10BN/Mcwi |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
male |
80 days-99 days |
10 |
2.09 |
ml/min |
0.55 |
1.74 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52141 |
482 |
LE/BluGill |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
male |
80 days-99 days |
6 |
2.56 |
ml/min |
0.2 |
0.5 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan |
52291 |
482 |
SD |
creatinine clearance |
nephrectomy then controlled content diet (1.2 %) (for 70 days) then controlled content diet (1 %) (for 70 days) |
Watanabe K, et al., J Atheroscler Thromb. 2017 Jul 1. doi: 10.5551/jat.40170. |
glomerular filtration trait |
male |
140 days
| 6 |
2.6 |
ml/min |
0.2 |
0.49 |
|
urine creatinine analysis |
0.0 |
unx |
84 |
days |
|
|
|
100136 |
2419 |
SDT/Jcl |
creatinine clearance |
nephrectomy then controlled content diet (1.2 %) (for 70 days) then controlled content diet (1 %) (for 70 days) and paricalcitol (0.1 ug/kg) (for 70 days) |
Watanabe K, et al., J Atheroscler Thromb. 2017 Jul 1. doi: 10.5551/jat.40170. |
glomerular filtration trait |
male |
140 days
| 7 |
2.3 |
ml/min |
0.2 |
0.53 |
|
urine creatinine analysis |
0.0 |
unx |
84 |
days |
|
|
|
100137 |
2419 |
SR/Hsd |
creatinine clearance |
standard diet |
Wu F, et al., Int J Hypertens. 2016;2016:9146870. doi: 10.1155/2016/9146870. Epub 2016 Dec 19. |
glomerular filtration trait |
male |
49 days
| 8 |
3.5 |
ml/min |
0.07 |
0.2 |
|
urine creatinine analysis |
0.0 |
|
0 |
|
|
|
|
102287 |
2683 |
WKY/NHsd |
creatinine clearance |
controlled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) |
Lankhorst S, et al., Hypertension. 2017 May;69(5):919-926. doi: 10.1161/HYPERTENSIONAHA.116.08565. Epub 2017 Mar 20. |
glomerular filtration trait |
male |
0 days
| 7 |
3.5 |
ml/min |
0.3 |
0.79 |
|
urine creatinine analysis |
0.0 |
|
0 |
|
|
|
|
99181 |
2238 |
SHRSP/A3NCrl |
creatinine clearance |
controlled sodium chloride content drinking water (1 %) (for 91 days) and controlled fat content diet (24.5 %) (for 91 days) then controlled SB-239063 content diet (1200 ppm) (for 35 days) |
Lenhard SC, etal., J Pharmacol Exp Ther. 2003 Dec;307(3):939-46. doi: 10.1124/jpet.103.057398. Epub 2003 Oct 15. |
glomerular filtration trait |
male |
161 days-175 days |
8 |
2.0 |
ml/min |
0.2 |
0.57 |
|
urine creatinine analysis |
0.0 |
|
0 |
|
|
|
|
107389 |
3083 |
MWF |
creatinine clearance |
controlled enalapril content drinking water (10 mg/kg) (between 0 and 672 hours) |
Schie?l IM, etal., J Pharmacol Exp Ther. 2015 May;353(2):299-306. doi: 10.1124/jpet.114.222125. Epub 2015 Feb 13. |
glomerular filtration trait |
male |
393 days
| 6 |
3.58 |
ml/min |
0.3 |
0.73 |
|
urine creatinine analysis |
0.0 |
|
0 |
|
|
|
|
108066 |
3113 |
SS/JrHsdMcwi |
creatinine clearance |
controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) |
PhysGen Renal A data |
glomerular filtration trait |
male |
87 days-120 days |
15 |
1.61 |
ml/min |
0.19 |
0.75 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms and pups used in studies were fed Dyets |
51541 |
481 |
PCK-Pkhd1pck/CrljCrl |
creatinine clearance |
control condition |
Goto M, et al., Pediatr Nephrol. 2010 Dec;25(12):2449-57. doi: 10.1007/s00467-010-1621-z. Epub 2010 Aug 27. |
glomerular filtration trait |
male |
60 days
| 3 |
0.0 |
ml/min |
0.0 |
0.0 |
|
urine creatinine analysis |
0.0 |
|
0 |
|
|
|
|
100209 |
2439 |
SS/JrHsdMcwi |
creatinine clearance |
controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) |
Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. |
glomerular filtration trait |
female |
90 days-94 days |
13 |
1.2 |
ml/min |
0.2 |
0.72 |
|
urine creatinine analysis |
0.0 |
|
0 |
|
plasma creatinine analysis |
|
|
67284 |
151 |
SS-Chr 10BN/Mcwi |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
female |
80 days-99 days |
8 |
1.42 |
ml/min |
0.15 |
0.42 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52150 |
482 |
SS-Chr 18BN/Mcwi |
creatinine clearance |
controlled sodium content diet (4 %) (between 17 and 36 days) |
PhysGen Renal A data |
glomerular filtration trait |
male |
87 days-120 days |
7 |
1.73 |
ml/min |
0.16 |
0.42 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms and pups used in studies were fed Dyets |
51796 |
481 |
SS-Chr 16BN/Mcwi |
creatinine clearance |
controlled sodium content diet (4 %) (between 17 and 36 days) |
PhysGen Renal A data |
glomerular filtration trait |
female |
87 days-120 days |
6 |
1.43 |
ml/min |
0.07 |
0.17 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms and pups used in studies were fed Dyets |
51799 |
481 |
FHH-Chr 13BN/Mcwi |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
female |
80 days-99 days |
7 |
1.73 |
ml/min |
0.25 |
0.66 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52353 |
482 |
FHH-Chr 4BN/Mcwi |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
female |
80 days-99 days |
7 |
1.26 |
ml/min |
0.12 |
0.31 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52372 |
482 |
FHH-Chr 10BN/Mcwi |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
male |
80 days-99 days |
4 |
1.62 |
ml/min |
0.23 |
0.47 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52378 |
482 |
SS-Chr 3BN/Mcwi |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
male |
80 days-99 days |
8 |
2.03 |
ml/min |
0.32 |
0.9 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52161 |
482 |
SS-Chr 13BN/Mcwi |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
male |
80 days-99 days |
15 |
2.38 |
ml/min |
0.23 |
0.87 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52167 |
482 |
SS-Chr 1BN/Mcwi |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
male |
80 days-99 days |
14 |
2.08 |
ml/min |
0.21 |
0.79 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52172 |
482 |
SS-Chr 1BN/Mcwi |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
female |
80 days-99 days |
13 |
1.67 |
ml/min |
0.16 |
0.58 |
Download Values
|
urine creatinine analysis |
|
|
0 |
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52175 |
482 |
SS/JrHsdMcwi |
creatinine clearance |
controlled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) |
Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. |
glomerular filtration trait |
female |
92 days-94 days |
10 |
1.08 |
ml/min |
0.37 |
1.17 |
|
urine creatinine analysis |
0.0 |
|
0 |
|
|
mg/min |
|
69480 |
151 |