F344-AbatTn(sb-T2/Bart3)2.163Mcwi |
concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) |
controlled sodium content diet (4 %) (for 14 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
female |
70 days-84 days |
1 |
0.0 |
umol/l |
|
|
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
62787 |
528 |
F344-AbatTn(sb-T2/Bart3)2.163Mcwi |
logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) |
controlled sodium content diet (4 %) (for 14 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
male |
70 days-84 days |
1 |
-8.61 |
null |
|
|
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
EC50 value is moles/liter |
63113 |
528 |
F344-AbatTn(sb-T2/Bart3)2.163Mcwi |
acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled sodium content diet (4 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70 days-84 days |
1 |
100.0 |
% |
|
|
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
62643 |
528 |
F344-AbatTn(sb-T2/Bart3)2.163Mcwi |
maximum contractile force per wet weight of aorta |
controlled sodium content diet (4 %) (for 14 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
female |
70 days-84 days |
1 |
0.92 |
g/mg |
|
|
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
63179 |
528 |
F344-AbatTn(sb-T2/Bart3)2.163Mcwi |
acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled sodium content diet (4 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70 days-84 days |
1 |
30.0 |
% |
|
|
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
62640 |
528 |
F344-AbatTn(sb-T2/Bart3)2.163Mcwi |
concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) |
controlled sodium content diet (4 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70 days-84 days |
1 |
1.92 |
E-7mole |
|
|
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
63043 |
528 |
F344-AbatTn(sb-T2/Bart3)2.163Mcwi |
concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) |
controlled sodium content diet (4 %) (for 14 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
male |
70 days-84 days |
1 |
0.0 |
umol/l |
|
|
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
62790 |
528 |
F344-AbatTn(sb-T2/Bart3)2.163Mcwi |
concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) |
controlled sodium content diet (4 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70 days-84 days |
1 |
2.24 |
E-7mole |
|
|
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
63040 |
528 |
F344-AbatTn(sb-T2/Bart3)2.163Mcwi |
logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) |
controlled sodium content diet (4 %) (for 14 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
female |
70 days-84 days |
1 |
-8.89 |
null |
|
|
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
EC50 value is moles/liter |
63110 |
528 |
F344-AbatTn(sb-T2/Bart3)2.163Mcwi |
maximum contractile force per wet weight of aorta |
controlled sodium content diet (4 %) (for 14 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
male |
70 days-84 days |
1 |
0.93 |
g/mg |
|
|
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
63182 |
528 |
F344-AbatTn(sb-T2/Bart3)2.163Mcwi |
logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) |
controlled sodium content diet (4 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70 days-84 days |
1 |
-6.65 |
null |
|
|
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
62863 |
528 |
F344-AbatTn(sb-T2/Bart3)2.163Mcwi |
logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) |
controlled sodium content diet (4 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70 days-84 days |
1 |
-6.72 |
null |
|
|
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
62866 |
528 |