Phenominer Database Results (84 results)

 
 
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Strain Phenotype Conditions Study Experiment Name Sex Age # of Animals Value Units SEM SD Method Method Duration Post Insult Time Value Method Notes Clinical Measurement Notes Record ID Study ID
SS/Jr blood vessel contractile force measurement Kreb's solution perfusate then potassium chloride solution (40 mmol/l) Dutil J, et al., Physiol Genomics 2005 Mar 1;. vasoconstriction trait male 98 days 12 1.59 g 0.11 0.38 tissue force analysis utilizing a force transducer 0.0 0 69048 1096
SS/Jr logarithm of the concentration of angiotensin II at which the force of blood vessel contraction is half the maximum value (Log EC50) Kreb's solution perfusate then angiotensin II (0.3-300 umol/l) then NG-nitroarginine methyl ester (100 umol/l) Dutil J, et al., Physiol Genomics 2005 Mar 1;. vasoconstriction trait male 98 days 12 -7.92 null 0.36 1.25 tissue force analysis utilizing a force transducer 0.0 0 isometric force transducer 69071 1096
SHRSP/A3NCrl carbachol-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium chloride content drinking water (1 %) (for 56 days) and controlled fat content diet (24.5 %) (for 56 days) then controlled GSK2181236A content diet (0.1 mg/kg/d) (for 49 days) Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. vasodilation trait male 141 days-148 days 6 54.0 % 6.0 14.7 tissue force analysis utilizing a force transducer 0.0 0 percent reversal of contractile response to 0.3uM phenylephrine 107295 3073
SHRSP/A3NCrl carbachol-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium chloride content drinking water (1 %) (for 56 days) and controlled fat content diet (24.5 %) (for 56 days) then controlled BAY60-4552 content diet (3 mg/kg/d) (for 49 days) Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. vasodilation trait male 141 days-148 days 9 59.0 % 4.0 12.0 tissue force analysis utilizing a force transducer 0.0 0 percent reversal of contractile response to 0.3uM phenylephrine 107298 3073
SHRSP/A3NCrl concentration of carbachol at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium chloride content drinking water (1 %) (for 56 days) and controlled fat content diet (24.5 %) (for 56 days) Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. vasodilation trait male 141 days-148 days 8 260.0 nmol/l 74.0 209.3 tissue force analysis utilizing a force transducer 0.0 0 percent reversal of contractile response to 0.3uM phenylephrine 107300 3073
GK/Jpe logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled cholesterol content diet (1.25 %) (for 90 days) and controlled cocoa butter content diet (7.5 %) (for 90 days) Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. vasodilation trait male 540 days 7 -6.16 null 0.07 0.19 tissue force analysis utilizing a force transducer 0.0 0 109096 3108
GK/Jpe logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled cholesterol content diet (1.25 %) (for 90 days) and controlled cocoa butter content diet (7.5 %) (for 90 days) Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. vasodilation trait male 540 days 7 -6.4 null 0.02 0.04 tissue force analysis utilizing a force transducer 0.0 0 109106 3108
SHRSP/A3NCrl concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium chloride content drinking water (1 %) (for 56 days) and controlled fat content diet (24.5 %) (for 56 days) then controlled GSK2181236A content diet (0.1 mg/kg/d) (for 49 days) Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. vasoconstriction trait male 141 days-148 days 6 0.05 umol/l 0.01 0.02 tissue force analysis utilizing a force transducer 0.0 0 microMolar 107079 3073
SHRSP/A3NCrl concentration of BAY 60-4552 at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium chloride content drinking water (1 %) (for 56 days) and controlled fat content diet (24.5 %) (for 56 days) Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. vasodilation trait male 141 days-148 days 8 54.0 nmol/l 14.0 39.6 tissue force analysis utilizing a force transducer 0.0 0 high salt high fat diet 107307 3073
SHRSP/A3NCrl concentration of GSK2181236A at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium chloride content drinking water (1 %) (for 56 days) and controlled fat content diet (24.5 %) (for 56 days) Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. vasodilation trait male 141 days-148 days 8 321.0 nmol/l 168.0 475.18 tissue force analysis utilizing a force transducer 0.0 0 high salt high fat diet 107311 3073
GK/Jpe logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) control condition Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. vasodilation trait male 540 days 7 -6.4 null 0.03 0.08 tissue force analysis utilizing a force transducer 0.0 0 109105 3108
SHRSP/A3NCrl concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) control condition Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. vasoconstriction trait male 141 days-148 days 14 0.07 umol/l 0.01 0.02 tissue force analysis utilizing a force transducer 0.0 0 microMolar 107077 3073
SS.MNS-(D2Mit6-D2Rat303)/Ayd blood vessel contractile force measurement Kreb's solution perfusate then potassium chloride solution (40 mmol/l) and NG-nitroarginine methyl ester (100 umol/l) Dutil J, et al., Physiol Genomics 2005 Mar 1;. vasoconstriction trait male 98 days 13 1.6 g 0.12 0.43 tissue force analysis utilizing a force transducer 0.0 0 isometric force transducer 69051 1096
SHRSP/A3NCrl carbachol-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium chloride content drinking water (1 %) (for 56 days) and controlled fat content diet (24.5 %) (for 56 days) then controlled BAY60-4552 content diet (0.3 mg/kg/d) (for 49 days) Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. vasodilation trait male 141 days-148 days 4 48.0 % 14.0 28.0 tissue force analysis utilizing a force transducer 0.0 0 percent reversal of contractile response to 0.3uM phenylephrine 107297 3073
SHRSP/A3NCrl concentration of carbachol at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) control condition Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. vasodilation trait male 141 days-148 days 14 119.0 nmol/l 15.0 56.12 tissue force analysis utilizing a force transducer 0.0 0 percent reversal of contractile response to 0.3uM phenylephrine 107299 3073
SHRSP/A3NCrl concentration of carbachol at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium chloride content drinking water (1 %) (for 56 days) and controlled fat content diet (24.5 %) (for 56 days) then controlled GSK2181236A content diet (0.1 mg/kg/d) (for 49 days) Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. vasodilation trait male 141 days-148 days 6 460.0 nmol/l 83.0 203.31 tissue force analysis utilizing a force transducer 0.0 0 percent reversal of contractile response to 0.3uM phenylephrine 107302 3073
SHRSP/A3NCrl sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium chloride content drinking water (1 %) (for 56 days) and controlled fat content diet (24.5 %) (for 56 days) then controlled GSK2181236A content diet (1 mg/kg/d) (for 49 days) Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. vasodilation trait male 141 days-148 days 9 112.0 % 3.0 9.0 tissue force analysis utilizing a force transducer 0.0 0 percent reversal of contractile response to 0.3uM phenylephrine 107092 3073
SHRSP/A3NCrl phenylephrine-induced blood vessel contractile force expressed as percent of contractile force generated by potassium chloride controlled sodium chloride content drinking water (1 %) (for 56 days) and controlled fat content diet (24.5 %) (for 56 days) then controlled BAY60-4552 content diet (0.3 mg/kg/d) (for 49 days) Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. vasoconstriction trait male 141 days-148 days 4 93.0 % 8.0 16.0 tissue force analysis utilizing a force transducer 0.0 0 phenylephrine-induced blood vessel contractile force expressed as percent of contractile force generated by potassium chloride (CMO:0003664) 107075 3073
SHRSP/A3NCrl sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium chloride content drinking water (1 %) (for 56 days) and controlled fat content diet (24.5 %) (for 56 days) Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. vasodilation trait male 141 days-148 days 8 103.0 % 9.0 25.46 tissue force analysis utilizing a force transducer 0.0 0 percent reversal of contractile response to 0.3uM phenylephrine 107090 3073
SHRSP/A3NCrl sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium chloride content drinking water (1 %) (for 56 days) and controlled fat content diet (24.5 %) (for 56 days) then controlled BAY60-4552 content diet (3 mg/kg/d) (for 49 days) Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. vasodilation trait male 141 days-148 days 9 100.0 % 2.0 6.0 tissue force analysis utilizing a force transducer 0.0 0 percent reversal of contractile response to 0.3uM phenylephrine 107094 3073
GK/Jpe acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled cholesterol content diet (1.25 %) (for 90 days) and controlled cocoa butter content diet (7.5 %) (for 90 days) Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. vasodilation trait male 540 days 7 49.0 % 3.2 8.47 tissue force analysis utilizing a force transducer 0.0 0 109101 3108
GK/Jpe acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel control condition Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. vasodilation trait male 540 days 7 45.0 % 2.2 5.82 tissue force analysis utilizing a force transducer 0.0 0 109100 3108
GK/Jpe sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel control condition Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. vasodilation trait male 540 days 7 99.6 % 0.01 0.03 tissue force analysis utilizing a force transducer 0.0 0 109110 3108
GK/Jpe sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled cholesterol content diet (1.25 %) (for 90 days) and controlled cocoa butter content diet (7.5 %) (for 90 days) then alpha-lipoic acid (50 mg/kg) (for 90 days) Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. vasodilation trait male 540 days 7 99.5 % 0.05 0.13 tissue force analysis utilizing a force transducer 0.0 0 109113 3108
W/Jpe logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) control condition Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. vasodilation trait male 540 days 7 -6.85 null 0.1 0.26 tissue force analysis utilizing a force transducer 0.0 0 wistar 109094 3108
SHRSP/A3NCrl BAY 60-4552-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel control condition Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. vasodilation trait male 141 days-148 days 14 110.0 % 2.0 7.48 tissue force analysis utilizing a force transducer 0.0 0 percent reversal of contractile response to 0.3uM phenylephrine 107308 3073
SHRSP/A3NCrl sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium chloride content drinking water (1 %) (for 56 days) and controlled fat content diet (24.5 %) (for 56 days) then controlled BAY60-4552 content diet (0.3 mg/kg/d) (for 49 days) Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. vasodilation trait male 141 days-148 days 4 111.0 % 3.0 6.0 tissue force analysis utilizing a force transducer 0.0 0 percent reversal of contractile response to 0.3uM phenylephrine 107093 3073
SS/Jr blood vessel contractile force measurement Kreb's solution perfusate then potassium chloride solution (40 mmol/l) and NG-nitroarginine methyl ester (100 umol/l) Dutil J, et al., Physiol Genomics 2005 Mar 1;. vasoconstriction trait male 98 days 12 1.39 g 0.06 0.21 tissue force analysis utilizing a force transducer 0.0 0 isometric force transducer 69050 1096
SS.MNS-(D2Mit6-D2Rat303)/Ayd receptor-dependent blood vessel maximum contractile force to receptor-independent blood vessel maximum contractile force ratio Kreb's solution perfusate then phenylephrine (1-100 mmol/l) Dutil J, et al., Physiol Genomics 2005 Mar 1;. vasoconstriction trait male 98 days 13 100.16 % 5.63 20.3 tissue force analysis utilizing a force transducer 0.0 0 isometric force transducer 69053 1096
SS.MNS-(D2Mit6-D2Rat303)/Ayd receptor-dependent blood vessel maximum contractile force to receptor-independent blood vessel maximum contractile force ratio Kreb's solution perfusate then phenylephrine (1-100 mmol/l) and NG-nitroarginine methyl ester (100 umol/l) Dutil J, et al., Physiol Genomics 2005 Mar 1;. vasoconstriction trait male 98 days 13 143.03 % 6.62 23.87 tissue force analysis utilizing a force transducer 0.0 0 isometric force transducer 69057 1096
SS/Jr receptor-dependent blood vessel maximum contractile force to receptor-independent blood vessel maximum contractile force ratio Kreb's solution perfusate then angiotensin II (0.3-300 umol/l) Dutil J, et al., Physiol Genomics 2005 Mar 1;. vasoconstriction trait male 98 days 12 34.85 % 2.94 10.18 tissue force analysis utilizing a force transducer 0.0 0 isometric force transducer 69065 1096
SS.MNS-(D2Mit6-D2Rat303)/Ayd receptor-dependent blood vessel maximum contractile force to receptor-independent blood vessel maximum contractile force ratio Kreb's solution perfusate then angiotensin II (0.3-300 umol/l) Dutil J, et al., Physiol Genomics 2005 Mar 1;. vasoconstriction trait male 98 days 13 19.33 % 3.67 13.23 tissue force analysis utilizing a force transducer 0.0 0 isometric force transducer 69066 1096
SS.MNS-(D2Mit6-D2Rat303)/Ayd logarithm of the concentration of angiotensin II at which the force of blood vessel contraction is half the maximum value (Log EC50) Kreb's solution perfusate then angiotensin II (0.3-300 umol/l) Dutil J, et al., Physiol Genomics 2005 Mar 1;. vasoconstriction trait male 98 days 13 -7.86 null 0.27 0.97 tissue force analysis utilizing a force transducer 0.0 0 isometric force transducer 69068 1096
SS/Jr receptor-dependent blood vessel maximum contractile force to receptor-independent blood vessel maximum contractile force ratio Kreb's solution perfusate then angiotensin II (0.3-300 umol/l) and NG-nitroarginine methyl ester (100 umol/l) Dutil J, et al., Physiol Genomics 2005 Mar 1;. vasoconstriction trait male 98 days 12 50.61 % 5.29 18.33 tissue force analysis utilizing a force transducer 0.0 0 isometric force transducer 69069 1096
SHRSP/A3NCrl concentration of carbachol at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium chloride content drinking water (1 %) (for 56 days) and controlled fat content diet (24.5 %) (for 56 days) then controlled GSK2181236A content diet (1 mg/kg/d) (for 49 days) Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. vasodilation trait male 141 days-148 days 9 328.0 nmol/l 41.0 123.0 tissue force analysis utilizing a force transducer 0.0 0 percent reversal of contractile response to 0.3uM phenylephrine 107303 3073
SHRSP/A3NCrl concentration of carbachol at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium chloride content drinking water (1 %) (for 56 days) and controlled fat content diet (24.5 %) (for 56 days) then controlled BAY60-4552 content diet (0.3 mg/kg/d) (for 49 days) Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. vasodilation trait male 141 days-148 days 4 407.0 nmol/l 158.0 316.0 tissue force analysis utilizing a force transducer 0.0 0 percent reversal of contractile response to 0.3uM phenylephrine 107304 3073
SHRSP/A3NCrl concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium chloride content drinking water (1 %) (for 56 days) and controlled fat content diet (24.5 %) (for 56 days) Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. vasodilation trait male 141 days-148 days 8 0.16 10E-7mol/l 0.03 0.08 tissue force analysis utilizing a force transducer 0.0 0 nanoMolar 107084 3073
SHRSP/A3NCrl concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium chloride content drinking water (1 %) (for 56 days) and controlled fat content diet (24.5 %) (for 56 days) then controlled GSK2181236A content diet (1 mg/kg/d) (for 49 days) Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. vasodilation trait male 141 days-148 days 9 0.26 10E-7mol/l 0.1 0.3 tissue force analysis utilizing a force transducer 0.0 0 nanoMolar 107086 3073
SHRSP/A3NCrl concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium chloride content drinking water (1 %) (for 56 days) and controlled fat content diet (24.5 %) (for 56 days) then controlled BAY60-4552 content diet (0.3 mg/kg/d) (for 49 days) Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. vasodilation trait male 141 days-148 days 4 0.26 10E-7mol/l 0.15 0.3 tissue force analysis utilizing a force transducer 0.0 0 nanoMolar 107087 3073
GK/Jpe logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) control condition Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. vasodilation trait male 540 days 7 -5.87 null 0.07 0.19 tissue force analysis utilizing a force transducer 0.0 0 109095 3108
W/Jpe sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel control condition Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. vasodilation trait male 540 days 7 99.9 % 0.1 0.26 tissue force analysis utilizing a force transducer 0.0 0 wistar 109109 3108
GK/Jpe acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled cholesterol content diet (1.25 %) (for 90 days) and controlled cocoa butter content diet (7.5 %) (for 90 days) then alpha-lipoic acid (50 mg/kg) (for 90 days) Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. vasodilation trait male 540 days 7 70.0 % 2.1 5.56 tissue force analysis utilizing a force transducer 0.0 0 109103 3108
W/Jpe logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) control condition Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. vasodilation trait male 540 days 7 -5.87 null 0.04 0.11 tissue force analysis utilizing a force transducer 0.0 0 wistar 109104 3108
GK/Jpe logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled cholesterol content diet (1.25 %) (for 90 days) and controlled cocoa butter content diet (7.5 %) (for 90 days) then alpha-lipoic acid (50 mg/kg) (for 90 days) Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. vasodilation trait male 540 days 7 -6.25 null 0.07 0.19 tissue force analysis utilizing a force transducer 0.0 0 109108 3108
SHRSP/A3NCrl phenylephrine-induced blood vessel contractile force expressed as percent of contractile force generated by potassium chloride control condition Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. vasoconstriction trait male 141 days-148 days 14 90.0 % 4.0 14.97 tissue force analysis utilizing a force transducer 0.0 0 phenylephrine-induced blood vessel contractile force expressed as percent of contractile force generated by potassium chloride (CMO:0003664) 107071 3073
SHRSP/A3NCrl concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium chloride content drinking water (1 %) (for 56 days) and controlled fat content diet (24.5 %) (for 56 days) then controlled BAY60-4552 content diet (3 mg/kg/d) (for 49 days) Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. vasoconstriction trait male 141 days-148 days 9 0.08 umol/l 0.02 0.05 tissue force analysis utilizing a force transducer 0.0 0 microMolar 107082 3073
SHRSP/A3NCrl concentration of GSK2181236A at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) control condition Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. vasodilation trait male 141 days-148 days 14 270.0 nmol/l 70.0 261.92 tissue force analysis utilizing a force transducer 0.0 0 standard rat chow 107310 3073
SHRSP/A3NCrl GSK2181236A-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel control condition Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. vasodilation trait male 141 days-148 days 14 110.0 % 3.0 11.22 tissue force analysis utilizing a force transducer 0.0 0 percent reversal of contractile response to 0.3uM phenylephrine 107312 3073
SS/Jr logarithm of the concentration of angiotensin II at which the force of blood vessel contraction is half the maximum value (Log EC50) Kreb's solution perfusate then angiotensin II (0.3-300 umol/l) Dutil J, et al., Physiol Genomics 2005 Mar 1;. vasoconstriction trait male 98 days 12 -8.22 null 0.26 0.9 tissue force analysis utilizing a force transducer 0.0 0 isometric force transducer 69067 1096
SS.MNS-(D2Mit6-D2Rat303)/Ayd logarithm of the concentration of angiotensin II at which the force of blood vessel contraction is half the maximum value (Log EC50) Kreb's solution perfusate then angiotensin II (0.3-300 umol/l) and NG-nitroarginine methyl ester (100 umol/l) Dutil J, et al., Physiol Genomics 2005 Mar 1;. vasoconstriction trait male 98 days 13 -7.2 null 0.31 1.12 tissue force analysis utilizing a force transducer 0.0 0 isometric force transducer 69072 1096
SS.MNS-(D2Mit6-D2Rat303)/Ayd blood vessel contractile force measurement Kreb's solution perfusate then potassium chloride solution (40 mmol/l) Dutil J, et al., Physiol Genomics 2005 Mar 1;. vasoconstriction trait male 98 days 13 1.62 g 0.09 0.32 tissue force analysis utilizing a force transducer 0.0 0 isometric force transducer 69049 1096
SS/Jr receptor-dependent blood vessel maximum contractile force to receptor-independent blood vessel maximum contractile force ratio Kreb's solution perfusate then phenylephrine (1-100 mmol/l) Dutil J, et al., Physiol Genomics 2005 Mar 1;. vasoconstriction trait male 98 days 12 104.06 % 4.7 16.28 tissue force analysis utilizing a force transducer 0.0 0 isometric force transducer 69052 1096
SS.MNS-(D2Mit6-D2Rat303)/Ayd logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) Kreb's solution perfusate then phenylephrine (1-100 mmol/l) Dutil J, et al., Physiol Genomics 2005 Mar 1;. vasoconstriction trait male 98 days 13 -6.96 null 0.17 0.61 tissue force analysis utilizing a force transducer 0.0 0 isometric force transducer EC50 value is probably moles/liter 69055 1096
SHRSP/A3NCrl concentration of carbachol at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium chloride content drinking water (1 %) (for 56 days) and controlled fat content diet (24.5 %) (for 56 days) then controlled BAY60-4552 content diet (3 mg/kg/d) (for 49 days) Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. vasodilation trait male 141 days-148 days 9 385.0 nmol/l 89.0 267.0 tissue force analysis utilizing a force transducer 0.0 0 percent reversal of contractile response to 0.3uM phenylephrine 107305 3073
SHRSP/A3NCrl concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium chloride content drinking water (1 %) (for 56 days) and controlled fat content diet (24.5 %) (for 56 days) then controlled BAY60-4552 content diet (0.3 mg/kg/d) (for 49 days) Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. vasoconstriction trait male 141 days-148 days 4 0.05 umol/l 0.01 0.02 tissue force analysis utilizing a force transducer 0.0 0 107081 3073
SHRSP/A3NCrl sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel control condition Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. vasodilation trait male 141 days-148 days 14 108.0 % 4.0 14.97 tissue force analysis utilizing a force transducer 0.0 0 percent reversal of contractile response to 0.3uM phenylephrine 107089 3073
SHRSP/A3NCrl phenylephrine-induced blood vessel contractile force expressed as percent of contractile force generated by potassium chloride controlled sodium chloride content drinking water (1 %) (for 56 days) and controlled fat content diet (24.5 %) (for 56 days) then controlled GSK2181236A content diet (1 mg/kg/d) (for 49 days) Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. vasoconstriction trait male 141 days-148 days 9 89.0 % 7.0 21.0 tissue force analysis utilizing a force transducer 0.0 0 phenylephrine-induced blood vessel contractile force expressed as percent of contractile force generated by potassium chloride (CMO:0003664) 107074 3073
SHRSP/A3NCrl phenylephrine-induced blood vessel contractile force expressed as percent of contractile force generated by potassium chloride controlled sodium chloride content drinking water (1 %) (for 56 days) and controlled fat content diet (24.5 %) (for 56 days) then controlled BAY60-4552 content diet (3 mg/kg/d) (for 49 days) Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. vasoconstriction trait male 141 days-148 days 9 91.0 % 8.0 24.0 tissue force analysis utilizing a force transducer 0.0 0 phenylephrine-induced blood vessel contractile force expressed as percent of contractile force generated by potassium chloride (CMO:0003664) 107076 3073
SHRSP/A3NCrl concentration of BAY 60-4552 at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) control condition Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. vasodilation trait male 141 days-148 days 14 75.0 nmol/l 16.0 59.87 tissue force analysis utilizing a force transducer 0.0 0 standard rat chow 107306 3073
SHRSP/A3NCrl sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium chloride content drinking water (1 %) (for 56 days) and controlled fat content diet (24.5 %) (for 56 days) then controlled GSK2181236A content diet (0.1 mg/kg/d) (for 49 days) Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. vasodilation trait male 141 days-148 days 6 98.0 % 5.0 12.25 tissue force analysis utilizing a force transducer 0.0 0 percent reversal of contractile response to 0.3uM phenylephrine 107091 3073
SS/Jr logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) Kreb's solution perfusate then phenylephrine (1-100 mmol/l) Dutil J, et al., Physiol Genomics 2005 Mar 1;. vasoconstriction trait male 98 days 12 -7.26 null 0.06 0.21 tissue force analysis utilizing a force transducer 0.0 0 isometric force transducer EC50 value is probably moles/liter 69054 1096
SS/Jr receptor-dependent blood vessel maximum contractile force to receptor-independent blood vessel maximum contractile force ratio Kreb's solution perfusate then phenylephrine (1-100 mmol/l) and NG-nitroarginine methyl ester (100 umol/l) Dutil J, et al., Physiol Genomics 2005 Mar 1;. vasoconstriction trait male 98 days 12 141.72 % 7.73 26.78 tissue force analysis utilizing a force transducer 0.0 0 isometric force transducer 69056 1096
SS/Jr logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) Kreb's solution perfusate then phenylephrine (1-100 mmol/l) and NG-nitroarginine methyl ester (100 umol/l) Dutil J, et al., Physiol Genomics 2005 Mar 1;. vasoconstriction trait male 98 days 12 -7.6 null 0.05 0.17 tissue force analysis utilizing a force transducer 0.0 0 isometric force transducer EC50 value is probably moles/liter 69058 1096
SHRSP/A3NCrl phenylephrine-induced blood vessel contractile force expressed as percent of contractile force generated by potassium chloride controlled sodium chloride content drinking water (1 %) (for 56 days) and controlled fat content diet (24.5 %) (for 56 days) then controlled GSK2181236A content diet (0.1 mg/kg/d) (for 49 days) Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. vasoconstriction trait male 141 days-148 days 6 88.0 % 6.0 14.7 tissue force analysis utilizing a force transducer 0.0 0 phenylephrine-induced blood vessel contractile force expressed as percent of contractile force generated by potassium chloride (CMO:0003664) 107073 3073
SHRSP/A3NCrl concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium chloride content drinking water (1 %) (for 56 days) and controlled fat content diet (24.5 %) (for 56 days) Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. vasoconstriction trait male 141 days-148 days 8 0.07 umol/l 0.01 0.03 tissue force analysis utilizing a force transducer 0.0 0 microMolar 107078 3073
SHRSP/A3NCrl concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium chloride content drinking water (1 %) (for 56 days) and controlled fat content diet (24.5 %) (for 56 days) then controlled GSK2181236A content diet (1 mg/kg/d) (for 49 days) Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. vasoconstriction trait male 141 days-148 days 9 0.05 umol/l 0.01 0.02 tissue force analysis utilizing a force transducer 0.0 0 microMolar 107080 3073
SHRSP/A3NCrl concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) control condition Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. vasodilation trait male 141 days-148 days 14 0.05 10E-7mol/l 0.01 0.04 tissue force analysis utilizing a force transducer 0.0 0 nanoMolar 107083 3073
SHRSP/A3NCrl concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium chloride content drinking water (1 %) (for 56 days) and controlled fat content diet (24.5 %) (for 56 days) then controlled GSK2181236A content diet (0.1 mg/kg/d) (for 49 days) Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. vasodilation trait male 141 days-148 days 6 0.25 10E-7mol/l 0.07 0.17 tissue force analysis utilizing a force transducer 0.0 0 nanoMolar 107085 3073
SHRSP/A3NCrl concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium chloride content drinking water (1 %) (for 56 days) and controlled fat content diet (24.5 %) (for 56 days) then controlled BAY60-4552 content diet (3 mg/kg/d) (for 49 days) Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. vasodilation trait male 141 days-148 days 9 0.19 10E-7mol/l 0.05 0.15 tissue force analysis utilizing a force transducer 0.0 0 nanoMolar 107088 3073
SHRSP/A3NCrl carbachol-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel control condition Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. vasodilation trait male 141 days-148 days 14 85.0 % 3.0 11.22 tissue force analysis utilizing a force transducer 0.0 0 percent reversal of contractile response to 0.3uM phenylephrine 107293 3073
SHRSP/A3NCrl carbachol-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium chloride content drinking water (1 %) (for 56 days) and controlled fat content diet (24.5 %) (for 56 days) Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. vasodilation trait male 141 days-148 days 8 47.0 % 11.0 31.11 tissue force analysis utilizing a force transducer 0.0 0 percent reversal of contractile response to 0.3uM phenylephrine 107294 3073
SHRSP/A3NCrl carbachol-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium chloride content drinking water (1 %) (for 56 days) and controlled fat content diet (24.5 %) (for 56 days) then controlled GSK2181236A content diet (1 mg/kg/d) (for 49 days) Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. vasodilation trait male 141 days-148 days 9 67.0 % 6.0 18.0 tissue force analysis utilizing a force transducer 0.0 0 percent reversal of contractile response to 0.3uM phenylephrine 107296 3073
GK/Jpe logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled cholesterol content diet (1.25 %) (for 90 days) and controlled cocoa butter content diet (7.5 %) (for 90 days) then soybean oil (2 ml/kg) (for 90 days) Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. vasodilation trait male 540 days 7 -6.23 null 0.23 0.61 tissue force analysis utilizing a force transducer 0.0 0 109097 3108
GK/Jpe logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled cholesterol content diet (1.25 %) (for 90 days) and controlled cocoa butter content diet (7.5 %) (for 90 days) then alpha-lipoic acid (50 mg/kg) (for 90 days) Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. vasodilation trait male 540 days 7 -6.6 null 0.1 0.26 tissue force analysis utilizing a force transducer 0.0 0 109098 3108
GK/Jpe sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled cholesterol content diet (1.25 %) (for 90 days) and controlled cocoa butter content diet (7.5 %) (for 90 days) Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. vasodilation trait male 540 days 7 99.5 % 0.15 0.4 tissue force analysis utilizing a force transducer 0.0 0 109111 3108
GK/Jpe sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled cholesterol content diet (1.25 %) (for 90 days) and controlled cocoa butter content diet (7.5 %) (for 90 days) then soybean oil (2 ml/kg) (for 90 days) Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. vasodilation trait male 540 days 7 99.5 % 0.11 0.29 tissue force analysis utilizing a force transducer 0.0 0 109112 3108
W/Jpe acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel control condition Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. vasodilation trait male 540 days 7 78.5 % 3.1 8.2 tissue force analysis utilizing a force transducer 0.0 0 wistar 109099 3108
SHRSP/A3NCrl phenylephrine-induced blood vessel contractile force expressed as percent of contractile force generated by potassium chloride controlled sodium chloride content drinking water (1 %) (for 56 days) and controlled fat content diet (24.5 %) (for 56 days) Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. vasoconstriction trait male 141 days-148 days 8 83.0 % 10.0 28.28 tissue force analysis utilizing a force transducer 0.0 0 phenylephrine-induced blood vessel contractile force expressed as percent of contractile force generated by potassium chloride (CMO:0003664) 107072 3073
SHRSP/A3NCrl BAY 60-4552-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium chloride content drinking water (1 %) (for 56 days) and controlled fat content diet (24.5 %) (for 56 days) Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. vasodilation trait male 141 days-148 days 8 111.0 % 2.0 5.66 tissue force analysis utilizing a force transducer 0.0 0 percent reversal of contractile response to 0.3uM phenylephrine 107309 3073
SHRSP/A3NCrl GSK2181236A-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium chloride content drinking water (1 %) (for 56 days) and controlled fat content diet (24.5 %) (for 56 days) Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. vasodilation trait male 141 days-148 days 8 110.0 % 7.0 19.8 tissue force analysis utilizing a force transducer 0.0 0 percent reversal of contractile response to 0.3uM phenylephrine 107313 3073
GK/Jpe acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled cholesterol content diet (1.25 %) (for 90 days) and controlled cocoa butter content diet (7.5 %) (for 90 days) then soybean oil (2 ml/kg) (for 90 days) Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. vasodilation trait male 540 days 7 55.0 % 2.5 6.61 tissue force analysis utilizing a force transducer 0.0 0 109102 3108
GK/Jpe logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled cholesterol content diet (1.25 %) (for 90 days) and controlled cocoa butter content diet (7.5 %) (for 90 days) then soybean oil (2 ml/kg) (for 90 days) Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. vasodilation trait male 540 days 7 -6.47 null 0.03 0.08 tissue force analysis utilizing a force transducer 0.0 0 109107 3108
SS.MNS-(D2Mit6-D2Rat303)/Ayd receptor-dependent blood vessel maximum contractile force to receptor-independent blood vessel maximum contractile force ratio Kreb's solution perfusate then angiotensin II (0.3-300 umol/l) and NG-nitroarginine methyl ester (100 umol/l) Dutil J, et al., Physiol Genomics 2005 Mar 1;. vasoconstriction trait male 98 days 13 26.63 % 4.0 14.42 tissue force analysis utilizing a force transducer 0.0 0 isometric force transducer 69070 1096
SS.MNS-(D2Mit6-D2Rat303)/Ayd logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) Kreb's solution perfusate then phenylephrine (1-100 mmol/l) and NG-nitroarginine methyl ester (100 umol/l) Dutil J, et al., Physiol Genomics 2005 Mar 1;. vasoconstriction trait male 98 days 13 -7.41 null 0.16 0.58 tissue force analysis utilizing a force transducer 0.0 0 isometric force transducer EC50 value is probably moles/liter 69059 1096