Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
PhenoMiner Database Result        View data table  |  Download data table  |  View expanded data table        


Generate Chart For    
    (Chart displayed below)
Rat Strains

{{sample.term}}
Measurement Methods

{{method.term}}
Age

{{ageRange}}
Experimental Conditions

     {{ cond }}

Minimum Value:    Maximum Value:    Sex:


 
Options:  View chart  |  Download data table  |  View expanded data table
# of AnimalsPhenotypeStrainSexValueUnitsConditionsRecord IDCondition 1aCondition 1bCondition 1cCondition 2aCondition 2bCondition 2cCondition 3Condition 4aCondition 4b
48mammary tumor growth rateSPRD/Ztmfemale0.7cm/week7,12-dimethyltetraphene (DMBA) (65 mg/kg) 113467,12-dimethyltetraphene (DMBA) (65 mg/kg)
46mammary tumor growth rateSPRD.WKY-(D18Wox8-D18Rat44)/Ibmmfemale0.79cm/week7,12-dimethyltetraphene (DMBA) (65 mg/kg) 113487,12-dimethyltetraphene (DMBA) (65 mg/kg)
14mammary tumor growth rateSPRD.WKY-(D5Rat190-D5Rat114)/Ibmmfemale0.62cm/week7,12-dimethyltetraphene (DMBA) (65 mg/kg) 113477,12-dimethyltetraphene (DMBA) (65 mg/kg)
36mammary tumor growth rateSPRD.WKY-(D5Rat190-D5Rat114)(D18Rat102-D18Rat44)/Ibmmfemale0.37cm/week7,12-dimethyltetraphene (DMBA) (65 mg/kg) (for 133 days)113497,12-dimethyltetraphene (DMBA) (65 mg/kg) (for 133 days)
25mammary tumor growth rateSPRD/Ztmfemale0.72cm/week7,12-dimethyltetraphene (DMBA) (65 mg/kg) (for 133 days)115097,12-dimethyltetraphene (DMBA) (65 mg/kg) (for 133 days)
16mammary tumor growth rateSPRD.WKY-(D5Rat190-D5Rat114)/Ibmmfemale0.65cm/week7,12-dimethyltetraphene (DMBA) (65 mg/kg) (for 133 days)115107,12-dimethyltetraphene (DMBA) (65 mg/kg) (for 133 days)
52mammary tumor growth rateSPRD.WKY-(D18Wox8-D18Rat44)/Ibmmfemale0.73cm/week7,12-dimethyltetraphene (DMBA) (65 mg/kg) (for 133 days)115117,12-dimethyltetraphene (DMBA) (65 mg/kg) (for 133 days)
33mammary tumor growth rateSPRD.WKY-(D10Rat91-D10Rat135)/Ibmmfemale0.53cm/week7,12-dimethyltetraphene (DMBA) (65 mg/kg) (for 133 days)115127,12-dimethyltetraphene (DMBA) (65 mg/kg) (for 133 days)
50mammary tumor numberWF/NHsdfemale6.97,12-dimethyltetraphene (DMBA) (65 mg/kg) 117437,12-dimethyltetraphene (DMBA) (65 mg/kg)
13mammary tumor numberWF.WKY-(D5Wox7-D5Uwm37)/Uwmfemale1.17,12-dimethyltetraphene (DMBA) (65 mg/kg) 117447,12-dimethyltetraphene (DMBA) (65 mg/kg)
29mammary tumor numberWF.WKY-(D5Rat26-D5Uwm42)/Uwmfemale5.77,12-dimethyltetraphene (DMBA) (65 mg/kg) 117457,12-dimethyltetraphene (DMBA) (65 mg/kg)
22urine sodium levelBN/NHsdMcwifemale100.4mmol/lcontrolled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) 69466controlled sodium content diet (0.4 %) (for 16 hours)furosemide (10 mg/kg)
14urine sodium levelSS/JrHsdMcwifemale149.5mmol/lcontrolled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) 69467controlled sodium content diet (0.4 %) (for 16 hours)furosemide (10 mg/kg)
22urine sodium excretion rateBN/NHsdMcwifemale0.45833304mEq/dcontrolled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) 69468controlled sodium content diet (0.4 %) (for 16 hours)furosemide (10 mg/kg)
14urine sodium excretion rateSS/JrHsdMcwifemale0.5555552mEq/dcontrolled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) 69469controlled sodium content diet (0.4 %) (for 16 hours)furosemide (10 mg/kg)
24urine sodium levelBN/NHsdMcwifemale370mmol/lcontrolled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days)69453controlled sodium content diet (0.4 %) (for 35 days)controlled sodium content diet (0.1 %) (for 35 days)controlled sodium content diet (8 %) (between 22 and 24 days)
17urine sodium levelSS/JrHsdMcwifemale338mmol/lcontrolled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days)69454controlled sodium content diet (0.4 %) (for 35 days)controlled sodium content diet (0.1 %) (for 35 days)controlled sodium content diet (8 %) (between 22 and 24 days)
24urine sodium excretion rateBN/NHsdMcwifemale6.3541626mEq/dcontrolled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days)69459controlled sodium content diet (0.4 %) (for 35 days)controlled sodium content diet (0.1 %) (for 35 days)controlled sodium content diet (8 %) (between 22 and 24 days)
17urine sodium excretion rateSS/JrHsdMcwifemale5.05555232mEq/dcontrolled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days)69460controlled sodium content diet (0.4 %) (for 35 days)controlled sodium content diet (0.1 %) (for 35 days)controlled sodium content diet (8 %) (between 22 and 24 days)
17urine potassium excretion rateSS/JrHsdMcwifemale1.0224mEq/dcontrolled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days)69470controlled sodium content diet (0.4 %) (for 35 days)controlled sodium content diet (0.1 %) (for 35 days)controlled sodium content diet (8 %) (between 22 and 24 days)
22urine potassium levelBN/NHsdMcwifemale93.4mmol/lcontrolled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) 69471controlled sodium content diet (0.4 %) (for 16 hours)furosemide (10 mg/kg)
14urine potassium levelSS/JrHsdMcwifemale124.4mmol/lcontrolled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) 69472controlled sodium content diet (0.4 %) (for 16 hours)furosemide (10 mg/kg)
22urine potassium excretion rateBN/NHsdMcwifemale0.8784mEq/dcontrolled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) 69473controlled sodium content diet (0.4 %) (for 16 hours)furosemide (10 mg/kg)
14urine potassium excretion rateSS/JrHsdMcwifemale0.9216mEq/dcontrolled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) 69474controlled sodium content diet (0.4 %) (for 16 hours)furosemide (10 mg/kg)
24urine potassium excretion rateBN/NHsdMcwifemale0.9648mEq/dcontrolled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days)69461controlled sodium content diet (0.4 %) (for 35 days)controlled sodium content diet (0.1 %) (for 35 days)controlled sodium content diet (8 %) (between 22 and 24 days)
13plasma total protein levelBN/NHsdMcwifemale38.6mg/mlcontrolled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days)69483controlled sodium content diet (0.4 %) (for 35 days)controlled sodium content diet (0.1 %) (for 35 days)controlled sodium content diet (8 %) (between 22 and 24 days)
13plasma total protein levelSS/JrHsdMcwifemale40.4mg/mlcontrolled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days)69484controlled sodium content diet (0.4 %) (for 35 days)controlled sodium content diet (0.1 %) (for 35 days)controlled sodium content diet (8 %) (between 22 and 24 days)
7tibia lengthSS/HsdMcwiCrlmale4.24cmcontrolled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days)67610controlled carbohydrate content diet (53 %) (for 91 days)controlled fat content diet (14 %) (for 91 days)controlled protein content diet (33 %) (for 91 days)
9tibia lengthSS/HsdMcwiCrlmale4.26cmcontrolled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days)67611controlled carbohydrate content diet (53 %) (for 63 days)controlled fat content diet (14 %) (for 63 days)controlled protein content diet (33 %) (for 63 days)controlled carbohydrate content diet (69 %) (for 28 days)controlled fat content diet (12 %) (for 28 days)controlled protein content diet (19 %) (for 28 days)
6tibia lengthSS/HsdMcwiCrlmale4.3cmcontrolled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days)67612controlled carbohydrate content diet (69 %) (for 91 days)controlled fat content diet (12 %) (for 91 days)controlled protein content diet (19 %) (for 91 days)
8tibia lengthSS/HsdMcwiCrlmale4.34cmcontrolled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days)67613controlled carbohydrate content diet (69 %) (for 63 days)controlled fat content diet (12 %) (for 63 days)controlled protein content diet (19 %) (for 63 days)controlled carbohydrate content diet (53 %) (for 28 days)controlled fat content diet (14 %) (for 28 days)controlled protein content diet (33 %) (for 28 days)
8food intake rateSS/HsdMcwiCrlmale25.2g/dcontrolled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days)67659controlled carbohydrate content diet (53 %) (for 91 days)controlled fat content diet (14 %) (for 91 days)controlled protein content diet (33 %) (for 91 days)
9food intake rateSS/HsdMcwiCrlmale21.4g/dcontrolled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days)67660controlled carbohydrate content diet (53 %) (for 63 days)controlled fat content diet (14 %) (for 63 days)controlled protein content diet (33 %) (for 63 days)controlled carbohydrate content diet (69 %) (for 28 days)controlled fat content diet (12 %) (for 28 days)controlled protein content diet (19 %) (for 28 days)
7food intake rateSS/HsdMcwiCrlmale20.9g/dcontrolled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days)67661controlled carbohydrate content diet (69 %) (for 91 days)controlled fat content diet (12 %) (for 91 days)controlled protein content diet (19 %) (for 91 days)
5food intake rateSS/HsdMcwiCrlmale25.4g/dcontrolled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days)67662controlled carbohydrate content diet (69 %) (for 63 days)controlled fat content diet (12 %) (for 63 days)controlled protein content diet (19 %) (for 63 days)controlled carbohydrate content diet (53 %) (for 28 days)controlled fat content diet (14 %) (for 28 days)controlled protein content diet (33 %) (for 28 days)
8water drink intake rateSS/HsdMcwiCrlmale30.1ml/dcontrolled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days)67663controlled carbohydrate content diet (53 %) (for 91 days)controlled fat content diet (14 %) (for 91 days)controlled protein content diet (33 %) (for 91 days)
9water drink intake rateSS/HsdMcwiCrlmale21.8ml/dcontrolled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days)67664controlled carbohydrate content diet (53 %) (for 63 days)controlled fat content diet (14 %) (for 63 days)controlled protein content diet (33 %) (for 63 days)controlled carbohydrate content diet (69 %) (for 28 days)controlled fat content diet (12 %) (for 28 days)controlled protein content diet (19 %) (for 28 days)
7water drink intake rateSS/HsdMcwiCrlmale18.4ml/dcontrolled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days)67665controlled carbohydrate content diet (69 %) (for 91 days)controlled fat content diet (12 %) (for 91 days)controlled protein content diet (19 %) (for 91 days)
5water drink intake rateSS/HsdMcwiCrlmale30.1ml/dcontrolled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days)67666controlled carbohydrate content diet (69 %) (for 63 days)controlled fat content diet (12 %) (for 63 days)controlled protein content diet (19 %) (for 63 days)controlled carbohydrate content diet (53 %) (for 28 days)controlled fat content diet (14 %) (for 28 days)controlled protein content diet (33 %) (for 28 days)
6urine pHSHR/NHsdMcomale7.2control condition (for 140 days)68014control condition (for 140 days)
6urine pHSS.SHR-(D2Rat61-D2Mco18)/Mcomale6.8control condition (for 140 days)68015control condition (for 140 days)
6urine pHSS/JrTolmale6.6control condition (for 140 days)68016control condition (for 140 days)
N/Aplasma creatinine levelSS-Rag1em1Mcwinot specified0.25mg/dlcontrolled sodium content diet (4 %) (for 21 days)69285controlled sodium content diet (4 %) (for 21 days)
N/Aplasma creatinine levelSS/JrHsdMcwinot specified0.34mg/dlcontrolled sodium content diet (4 %) (for 21 days)69286controlled sodium content diet (4 %) (for 21 days)
4urine albumin excretion rateSS-Rag1em2Mcwinot specified19mg/dcontrolled sodium content diet (4 %) (for 21 days)69293controlled sodium content diet (4 %) (for 21 days)
4urine albumin excretion rateSS/JrHsdMcwinot specified127mg/dcontrolled sodium content diet (4 %) (for 21 days)69294controlled sodium content diet (4 %) (for 21 days)
2plasma total cholesterol levelCrl:SDnot specified54.6mg/dlcontrol condition70158control condition
2plasma total cholesterol levelCrlj:WInot specified92mg/dlcontrol condition70159control condition
2plasma total cholesterol levelWKY/NCrlCrljnot specified63.4mg/dlcontrol condition70160control condition
2plasma total cholesterol levelSHR/NCrlnot specified58.3mg/dlcontrol condition70161control condition
4plasma total cholesterol levelGHnot specified84mg/dlcontrol condition70162control condition
2liver cholesterol levelCrl:SDnot specified1.72mg/gcontrol condition70163control condition
2liver cholesterol levelCrlj:WInot specified1.55mg/gcontrol condition70164control condition
2liver cholesterol levelWKY/NCrlCrljnot specified2.1mg/gcontrol condition70165control condition
2liver cholesterol levelSHR/NCrlnot specified1.85mg/gcontrol condition70166control condition
2brain campesterol levelCrl:SDnot specified0.02mg/gcontrol condition70528control condition
2brain campesterol levelCrlj:WInot specified0.02mg/gcontrol condition70529control condition
2brain campesterol levelWKY/NCrlCrljnot specified0.02mg/gcontrol condition70530control condition
2brain campesterol levelSHR/NCrlnot specified0.02mg/gcontrol condition70531control condition
2plasma campesterol levelCrl:SDnot specified1.3mg/dlcontrol condition70515control condition
2plasma campesterol levelCrlj:WInot specified1.9mg/dlcontrol condition70516control condition
2plasma campesterol levelWKY/NCrlCrljnot specified4.4mg/dlcontrol condition70517control condition
2plasma campesterol levelSHR/NCrlnot specified4mg/dlcontrol condition70518control condition
4plasma campesterol levelGHnot specified2.24mg/dlcontrol condition70519control condition
2liver campesterol levelCrl:SDnot specified0.03mg/gcontrol condition70520control condition
2liver campesterol levelCrlj:WInot specified0.04mg/gcontrol condition70521control condition
2liver campesterol levelWKY/NCrlCrljnot specified0.09mg/gcontrol condition70522control condition
2liver campesterol levelSHR/NCrlnot specified0.09mg/gcontrol condition70523control condition
2brain cholesterol levelCrl:SDnot specified10.95mg/gcontrol condition70524control condition
2brain cholesterol levelCrlj:WInot specified13.73mg/gcontrol condition70525control condition
2brain cholesterol levelWKY/NCrlCrljnot specified12.15mg/gcontrol condition70526control condition
2brain cholesterol levelSHR/NCrlnot specified11.76mg/gcontrol condition70527control condition
2plasma sitosterol levelCrl:SDnot specified1.95mg/dlcontrol condition70532control condition
2plasma sitosterol levelCrlj:WInot specified2.4mg/dlcontrol condition70533control condition
2plasma sitosterol levelWKY/NCrlCrljnot specified8.65mg/dlcontrol condition70534control condition
2plasma sitosterol levelSHR/NCrlnot specified6.25mg/dlcontrol condition70535control condition
4plasma sitosterol levelGHnot specified2.62mg/dlcontrol condition70536control condition
2liver sitosterol levelCrl:SDnot specified0.03mg/gcontrol condition70537control condition
2liver sitosterol levelCrlj:WInot specified0.04mg/gcontrol condition70538control condition
2liver sitosterol levelWKY/NCrlCrljnot specified0.14mg/gcontrol condition70539control condition
2liver sitosterol levelSHR/NCrlnot specified0.12mg/gcontrol condition70540control condition
2brain sitosterol levelWKY/NCrlCrljnot specified0.03mg/gcontrol condition70543control condition
2brain sitosterol levelCrlj:WInot specified0.04mg/gcontrol condition70542control condition
2brain sitosterol levelSHR/NCrlnot specified0.01mg/gcontrol condition70544control condition
2brain sitosterol levelCrl:SDnot specified0.02mg/gcontrol condition70541control condition
2plasma phytosterol levelCrl:SDnot specified3.3mg/dlcontrol condition70545control condition
2plasma phytosterol levelCrlj:WInot specified4.3mg/dlcontrol condition70546control condition
2plasma phytosterol levelWKY/NCrlCrljnot specified13.1mg/dlcontrol condition70547control condition
2plasma phytosterol levelSHR/NCrlnot specified10.3mg/dlcontrol condition70548control condition
4plasma phytosterol levelGHnot specified4.9mg/dlcontrol condition70549control condition
2liver phytosterol levelCrl:SDnot specified0.05mg/gcontrol condition70550control condition
2liver phytosterol levelCrlj:WInot specified0.08mg/gcontrol condition70551control condition
2liver phytosterol levelWKY/NCrlCrljnot specified0.24mg/gcontrol condition70552control condition
2liver phytosterol levelSHR/NCrlnot specified0.21mg/gcontrol condition70553control condition
2brain phytosterol levelCrl:SDnot specified0.03mg/gcontrol condition70554control condition
2brain phytosterol levelCrlj:WInot specified0.06mg/gcontrol condition70555control condition
2brain phytosterol levelWKY/NCrlCrljnot specified0.05mg/gcontrol condition70556control condition
2brain phytosterol levelSHR/NCrlnot specified0.03mg/gcontrol condition70557control condition
12food intake rateCrl:SDfemale10.8g/dcontrolled ethanol content drinking water (1 %) (for 7 days)75717controlled ethanol content drinking water (1 %) (for 7 days)
12food intake rateCrl:SDfemale10g/dcontrolled fructose content drinking water (5 %) (for 7 days) and controlled bisphenol A content drinking water (0.025 mg/l) (for 7 days)75719controlled fructose content drinking water (5 %) (for 7 days)controlled bisphenol A content drinking water (0.025 mg/l) (for 7 days)
12food intake rateCrl:SDfemale8.7g/dcontrolled fructose content drinking water (5 %) (between 7 and 70 days) and controlled bisphenol A content drinking water (2.5 mg/l) (between 7 and 70 days)75741controlled fructose content drinking water (5 %) (between 7 and 70 days)controlled bisphenol A content drinking water (2.5 mg/l) (between 7 and 70 days)
12food intake rateCrl:SDfemale8.3g/dcontrolled fructose content drinking water (5 %) (between 7 and 70 days) and controlled bisphenol A content drinking water (0.25 mg/l) (between 7 and 70 days)75740controlled fructose content drinking water (5 %) (between 7 and 70 days)controlled bisphenol A content drinking water (0.25 mg/l) (between 7 and 70 days)
12food intake rateCrl:SDfemale9.3g/dcontrolled fructose content drinking water (5 %) (for 7 days) and controlled bisphenol A content drinking water (2.5 mg/l) (for 7 days)75742controlled fructose content drinking water (5 %) (for 7 days)controlled bisphenol A content drinking water (2.5 mg/l) (for 7 days)
12food intake rateCrl:SDfemale10.1g/dcontrolled fructose content drinking water (5 %) (for 7 days) and controlled ethanol content drinking water (1 %) (for 7 days)75718controlled fructose content drinking water (5 %) (for 7 days)controlled ethanol content drinking water (1 %) (for 7 days)
12food intake rateCrl:SDfemale9.6g/dcontrolled fructose content drinking water (5 %) (for 7 days) and controlled bisphenol A content drinking water (0.25 mg/l) (for 7 days)75720controlled fructose content drinking water (5 %) (for 7 days)controlled bisphenol A content drinking water (0.25 mg/l) (for 7 days)
12food intake rateCrl:SDfemale10g/dcontrolled ethanol content drinking water (1 %) (for 70 days)75733controlled ethanol content drinking water (1 %) (for 70 days)
12food intake rateCrl:SDfemale8.3g/dcontrolled fructose content drinking water (5 %) (for 70 days) and controlled ethanol content drinking water (1 %) (for 70 days)75734controlled fructose content drinking water (5 %) (for 70 days)controlled ethanol content drinking water (1 %) (for 70 days)
12food intake rateCrl:SDfemale7.8g/dcontrolled fructose content drinking water (5 %) (for 70 days) and controlled bisphenol A content drinking water (0.25 mg/l) (for 70 days)75736controlled fructose content drinking water (5 %) (for 70 days)controlled bisphenol A content drinking water (0.25 mg/l) (for 70 days)
12food intake rateCrl:SDfemale10.2g/dcontrolled ethanol content drinking water (1 %) (between 7 and 70 days)75737controlled ethanol content drinking water (1 %) (between 7 and 70 days)
12food intake rateCrl:SDfemale8.3g/dcontrolled fructose content drinking water (5 %) (for 70 days) and controlled bisphenol A content drinking water (2.5 mg/l) (for 70 days)75743controlled fructose content drinking water (5 %) (for 70 days)controlled bisphenol A content drinking water (2.5 mg/l) (for 70 days)
12food intake rateCrl:SDfemale7.9g/dcontrolled fructose content drinking water (5 %) (for 70 days) and controlled bisphenol A content drinking water (0.025 mg/l) (for 70 days)75735controlled fructose content drinking water (5 %) (for 70 days)controlled bisphenol A content drinking water (0.025 mg/l) (for 70 days)
12food intake rateCrl:SDfemale8.7g/dcontrolled fructose content drinking water (5 %) (between 7 and 70 days) and controlled ethanol content drinking water (1 %) (between 7 and 70 days)75738controlled fructose content drinking water (5 %) (between 7 and 70 days)controlled ethanol content drinking water (1 %) (between 7 and 70 days)
12food intake rateCrl:SDfemale8.5g/dcontrolled fructose content drinking water (5 %) (between 7 and 70 days) and controlled bisphenol A content drinking water (0.025 mg/l) (between 7 and 70 days)75739controlled fructose content drinking water (5 %) (between 7 and 70 days)controlled bisphenol A content drinking water (0.025 mg/l) (between 7 and 70 days)
12food calorie intake rateCrl:SDfemale28.9kcal/dcontrolled ethanol content drinking water (1 %) (between 7 and 70 days)76105controlled ethanol content drinking water (1 %) (between 7 and 70 days)
12food calorie intake rateCrl:SDfemale24.6kcal/dcontrolled fructose content drinking water (5 %) (between 7 and 70 days) and controlled ethanol content drinking water (1 %) (between 7 and 70 days)76106controlled fructose content drinking water (5 %) (between 7 and 70 days)controlled ethanol content drinking water (1 %) (between 7 and 70 days)
12food calorie intake rateCrl:SDfemale24.1kcal/dcontrolled fructose content drinking water (5 %) (between 7 and 70 days) and controlled bisphenol A content drinking water (0.025 mg/l) (between 7 and 70 days)76107controlled fructose content drinking water (5 %) (between 7 and 70 days)controlled bisphenol A content drinking water (0.025 mg/l) (between 7 and 70 days)
12food calorie intake rateCrl:SDfemale23.5kcal/dcontrolled fructose content drinking water (5 %) (between 7 and 70 days) and controlled bisphenol A content drinking water (0.25 mg/l) (between 7 and 70 days)76108controlled fructose content drinking water (5 %) (between 7 and 70 days)controlled bisphenol A content drinking water (0.25 mg/l) (between 7 and 70 days)
12food calorie intake rateCrl:SDfemale24.6kcal/dcontrolled fructose content drinking water (5 %) (between 7 and 70 days) and controlled bisphenol A content drinking water (2.5 mg/l) (between 7 and 70 days)76109controlled fructose content drinking water (5 %) (between 7 and 70 days)controlled bisphenol A content drinking water (2.5 mg/l) (between 7 and 70 days)
12bisphenol A in fructose drink intake rateCrl:SDfemale20.4g/dcontrolled fructose content drinking water (5 %) (for 7 days) and controlled bisphenol A content drinking water (0.025 mg/l) (for 7 days)75723controlled fructose content drinking water (5 %) (for 7 days)controlled bisphenol A content drinking water (0.025 mg/l) (for 7 days)
12ethanol drink intake rateCrl:SDfemale10.8g/dcontrolled ethanol content drinking water (1 %) (for 70 days)75725controlled ethanol content drinking water (1 %) (for 70 days)
12bisphenol A in fructose drink intake rateCrl:SDfemale33g/dcontrolled fructose content drinking water (5 %) (for 70 days) and controlled bisphenol A content drinking water (0.025 mg/l) (for 70 days)75727controlled fructose content drinking water (5 %) (for 70 days)controlled bisphenol A content drinking water (0.025 mg/l) (for 70 days)
12ethanol drink intake rateCrl:SDfemale11.6g/dcontrolled ethanol content drinking water (1 %) (for 7 days)75721controlled ethanol content drinking water (1 %) (for 7 days)
12fructose drink intake rateCrl:SDfemale20.8g/dcontrolled fructose content drinking water (5 %) (for 7 days) and controlled ethanol content drinking water (1 %) (for 7 days)75722controlled fructose content drinking water (5 %) (for 7 days)controlled ethanol content drinking water (1 %) (for 7 days)
12bisphenol A in fructose drink intake rateCrl:SDfemale21.8g/dcontrolled fructose content drinking water (5 %) (for 7 days) and controlled bisphenol A content drinking water (0.25 mg/l) (for 7 days)75724controlled fructose content drinking water (5 %) (for 7 days)controlled bisphenol A content drinking water (0.25 mg/l) (for 7 days)
12fructose drink intake rateCrl:SDfemale32g/dcontrolled fructose content drinking water (5 %) (for 70 days) and controlled ethanol content drinking water (1 %) (for 70 days)75726controlled fructose content drinking water (5 %) (for 70 days)controlled ethanol content drinking water (1 %) (for 70 days)
12bisphenol A in fructose drink intake rateCrl:SDfemale30.1g/dcontrolled fructose content drinking water (5 %) (between 7 and 70 days) and controlled bisphenol A content drinking water (0.25 mg/l) (between 7 and 70 days)75732controlled fructose content drinking water (5 %) (between 7 and 70 days)controlled bisphenol A content drinking water (0.25 mg/l) (between 7 and 70 days)
12bisphenol A in fructose drink intake rateCrl:SDfemale19.8g/dcontrolled fructose content drinking water (5 %) (for 7 days) and controlled bisphenol A content drinking water (2.5 mg/l) (for 7 days)75744controlled fructose content drinking water (5 %) (for 7 days)controlled bisphenol A content drinking water (2.5 mg/l) (for 7 days)
12bisphenol A in fructose drink intake rateCrl:SDfemale36.8g/dcontrolled fructose content drinking water (5 %) (for 70 days) and controlled bisphenol A content drinking water (0.25 mg/l) (for 70 days)75728controlled fructose content drinking water (5 %) (for 70 days)controlled bisphenol A content drinking water (0.25 mg/l) (for 70 days)
12ethanol drink intake rateCrl:SDfemale11.5g/dcontrolled ethanol content drinking water (1 %) 75729controlled ethanol content drinking water (1 %)
12fructose drink intake rateCrl:SDfemale28.3g/dcontrolled fructose content drinking water (5 %) (between 7 and 70 days) and controlled ethanol content drinking water (1 %) (between 7 and 70 days)75730controlled fructose content drinking water (5 %) (between 7 and 70 days)controlled ethanol content drinking water (1 %) (between 7 and 70 days)
12bisphenol A in fructose drink intake rateCrl:SDfemale28.1g/dcontrolled fructose content drinking water (5 %) (between 7 and 70 days) and controlled bisphenol A content drinking water (0.025 mg/l) (between 7 and 70 days)75731controlled fructose content drinking water (5 %) (between 7 and 70 days)controlled bisphenol A content drinking water (0.025 mg/l) (between 7 and 70 days)
12bisphenol A in fructose drink intake rateCrl:SDfemale29.4g/dcontrolled fructose content drinking water (5 %) (for 70 days) and controlled bisphenol A content drinking water (2.5 mg/l) (for 70 days)75745controlled fructose content drinking water (5 %) (for 70 days)controlled bisphenol A content drinking water (2.5 mg/l) (for 70 days)
12bisphenol A in fructose drink intake rateCrl:SDfemale24.7g/dcontrolled fructose content drinking water (5 %) (between 7 and 70 days) and controlled bisphenol A content drinking water (2.5 mg/l) (between 7 and 70 days)75746controlled fructose content drinking water (5 %) (between 7 and 70 days)controlled bisphenol A content drinking water (2.5 mg/l) (between 7 and 70 days)
12fructose drink calorie intake rateCrl:SDfemale0kcal/dcontrolled ethanol content drinking water (1 %) (between 7 and 70 days)76100controlled ethanol content drinking water (1 %) (between 7 and 70 days)
12fructose drink calorie intake rateCrl:SDfemale5.7kcal/dcontrolled fructose content drinking water (5 %) (between 7 and 70 days)76101controlled fructose content drinking water (5 %) (between 7 and 70 days)
12fructose drink calorie intake rateCrl:SDfemale5.6kcal/dcontrolled fructose content drinking water (5 %) (between 7 and 70 days) and controlled bisphenol A content drinking water (0.025 mg/l) (between 7 and 70 days)76102controlled fructose content drinking water (5 %) (between 7 and 70 days)controlled bisphenol A content drinking water (0.025 mg/l) (between 7 and 70 days)
12fructose drink calorie intake rateCrl:SDfemale6kcal/dcontrolled fructose content drinking water (5 %) (between 7 and 70 days) and controlled bisphenol A content drinking water (0.25 mg/l) (between 7 and 70 days)76103controlled fructose content drinking water (5 %) (between 7 and 70 days)controlled bisphenol A content drinking water (0.25 mg/l) (between 7 and 70 days)
12fructose drink calorie intake rateCrl:SDfemale4.9kcal/dcontrolled fructose content drinking water (5 %) (between 7 and 70 days) and controlled bisphenol A content drinking water (2.5 mg/l) (between 7 and 70 days)76104controlled fructose content drinking water (5 %) (between 7 and 70 days)controlled bisphenol A content drinking water (2.5 mg/l) (between 7 and 70 days)
12total calorie intake rateCrl:SDfemale28.9kcal/dcontrolled ethanol content drinking water (1 %) (between 7 and 70 days)76110controlled ethanol content drinking water (1 %) (between 7 and 70 days)
12total calorie intake rateCrl:SDfemale30.3kcal/dcontrolled fructose content drinking water (5 %) (between 7 and 70 days) and controlled ethanol content drinking water (1 %) (between 7 and 70 days)76111controlled fructose content drinking water (5 %) (between 7 and 70 days)controlled ethanol content drinking water (1 %) (between 7 and 70 days)
12total calorie intake rateCrl:SDfemale29.7kcal/dcontrolled fructose content drinking water (5 %) (between 7 and 70 days) and controlled bisphenol A content drinking water (0.025 mg/l) (between 7 and 70 days)76112controlled fructose content drinking water (5 %) (between 7 and 70 days)controlled bisphenol A content drinking water (0.025 mg/l) (between 7 and 70 days)
12total calorie intake rateCrl:SDfemale29.5kcal/dcontrolled fructose content drinking water (5 %) (between 7 and 70 days) and controlled bisphenol A content drinking water (0.25 mg/l) (between 7 and 70 days)76113controlled fructose content drinking water (5 %) (between 7 and 70 days)controlled bisphenol A content drinking water (0.25 mg/l) (between 7 and 70 days)
12total calorie intake rateCrl:SDfemale29.5kcal/dcontrolled fructose content drinking water (5 %) (between 7 and 70 days) and controlled bisphenol A content drinking water (2.5 mg/l) (between 7 and 70 days)76114controlled fructose content drinking water (5 %) (between 7 and 70 days)controlled bisphenol A content drinking water (2.5 mg/l) (between 7 and 70 days)
8food calorie intake level to change in body weight ratioBluHsd:LEmale12.1kcal/gcontrolled in utero environment (for 9 days) and bisphenol A (25 ug/kg) (for 30 days) then maternal milk (for 21 days) then controlled fat content diet (21.2 %) (for 28 days)76186controlled in utero environment (for 9 days)bisphenol A (25 ug/kg) (for 30 days)maternal milk (for 21 days)controlled fat content diet (21.2 %) (for 28 days)
8food intake weight to change in body weight ratioBluHsd:LEmale4.7g/gcontrolled in utero environment (for 9 days) and bisphenol A (25 ug/kg) (for 30 days) then maternal milk (for 21 days) then controlled fat content diet (21.2 %) (for 28 days)76195controlled in utero environment (for 9 days)bisphenol A (25 ug/kg) (for 30 days)maternal milk (for 21 days)controlled fat content diet (21.2 %) (for 28 days)
8total food calorie intake rateBluHsd:LEmale2995.2kcal/dcontrolled in utero environment (for 9 days) and vehicle control condition (for 30 days) then maternal milk (for 21 days) then controlled fat content diet (21.2 %) (for 28 days)76182controlled in utero environment (for 9 days)vehicle control condition (for 30 days)maternal milk (for 21 days)controlled fat content diet (21.2 %) (for 28 days)
8total food calorie intake rateBluHsd:LEmale2990.7kcal/dcontrolled in utero environment (for 9 days) and bisphenol A (2.5 ug/kg) (for 30 days) then maternal milk (for 21 days) then controlled fat content diet (21.2 %) (for 28 days)76183controlled in utero environment (for 9 days)bisphenol A (2.5 ug/kg) (for 30 days)maternal milk (for 21 days)controlled fat content diet (21.2 %) (for 28 days)
8total food calorie intake rateBluHsd:LEmale2955.2kcal/dcontrolled in utero environment (for 9 days) and bisphenol A (25 ug/kg) (for 30 days) then maternal milk (for 21 days) then controlled fat content diet (21.2 %) (for 28 days)76184controlled in utero environment (for 9 days)bisphenol A (25 ug/kg) (for 30 days)maternal milk (for 21 days)controlled fat content diet (21.2 %) (for 28 days)
8food calorie intake level to change in body weight ratioBluHsd:LEmale10.1kcal/gcontrolled in utero environment (for 9 days) and vehicle control condition (for 30 days) then maternal milk (for 21 days)76204controlled in utero environment (for 9 days)vehicle control condition (for 30 days)maternal milk (for 21 days)
8food calorie intake level to change in body weight ratioBluHsd:LEmale10.4kcal/gcontrolled in utero environment (for 9 days) and bisphenol A (2.5 ug/kg) (for 30 days) then maternal milk (for 21 days) then controlled fat content diet (21.2 %) (for 28 days)76196controlled in utero environment (for 9 days)bisphenol A (2.5 ug/kg) (for 30 days)maternal milk (for 21 days)controlled fat content diet (21.2 %) (for 28 days)
8food intake weight to change in body weight ratioBluHsd:LEmale6.7g/gcontrolled in utero environment (for 9 days) and vehicle control condition (for 30 days) then maternal milk (for 21 days)76203controlled in utero environment (for 9 days)vehicle control condition (for 30 days)maternal milk (for 21 days)
8food calorie intake level to change in body weight ratioBluHsd:LEmale9.9kcal/gcontrolled in utero environment (for 9 days) and bisphenol A (25 ug/kg) (for 30 days) then maternal milk (for 21 days)76208controlled in utero environment (for 9 days)bisphenol A (25 ug/kg) (for 30 days)maternal milk (for 21 days)
8total food calorie intake rateBluHsd:LEmale2103.7kcal/dvehicle control condition (for 30 days) and controlled in utero environment (for 9 days) then maternal milk (for 21 days)76169vehicle control condition (for 30 days)controlled in utero environment (for 9 days)maternal milk (for 21 days)
8total food calorie intake rateBluHsd:LEmale2023kcal/dcontrolled in utero environment (for 9 days) and bisphenol A (2.5 ug/kg) (for 30 days) then maternal milk (for 21 days)76175controlled in utero environment (for 9 days)bisphenol A (2.5 ug/kg) (for 30 days)maternal milk (for 21 days)
8total food calorie intake rateBluHsd:LEmale1969.2kcal/dcontrolled in utero environment (for 9 days) and bisphenol A (25 ug/kg) (for 30 days) then maternal milk (for 21 days)76176controlled in utero environment (for 9 days)bisphenol A (25 ug/kg) (for 30 days)maternal milk (for 21 days)
8food intake weight to change in body weight ratioBluHsd:LEmale4.8g/gcontrolled in utero environment (for 9 days) and bisphenol A (2.5 ug/kg) (for 30 days) then maternal milk (for 21 days) then controlled fat content diet (21.2 %) (for 28 days)76185controlled in utero environment (for 9 days)bisphenol A (2.5 ug/kg) (for 30 days)maternal milk (for 21 days)controlled fat content diet (21.2 %) (for 28 days)
8food intake weight to change in body weight ratioBluHsd:LEmale4.7g/gcontrolled in utero environment (for 9 days) and vehicle control condition (for 30 days) then maternal milk (for 21 days) then controlled fat content diet (21.2 %) (for 28 days)76197controlled in utero environment (for 9 days)vehicle control condition (for 30 days)maternal milk (for 21 days)controlled fat content diet (21.2 %) (for 28 days)
8food calorie intake level to change in body weight ratioBluHsd:LEmale10.4kcal/gcontrolled in utero environment (for 9 days) and vehicle control condition (for 30 days) then maternal milk (for 21 days) then controlled fat content diet (21.2 %) (for 28 days)76198controlled in utero environment (for 9 days)vehicle control condition (for 30 days)maternal milk (for 21 days)controlled fat content diet (21.2 %) (for 28 days)
8food intake weight to change in body weight ratioBluHsd:LEmale7.1g/gcontrolled in utero environment (for 9 days) and bisphenol A (2.5 ug/kg) (for 30 days) then maternal milk (for 21 days)76205controlled in utero environment (for 9 days)bisphenol A (2.5 ug/kg) (for 30 days)maternal milk (for 21 days)
8food calorie intake level to change in body weight ratioBluHsd:LEmale9.8kcal/gcontrolled in utero environment (for 9 days) and bisphenol A (2.5 ug/kg) (for 30 days) then maternal milk (for 21 days)76206controlled in utero environment (for 9 days)bisphenol A (2.5 ug/kg) (for 30 days)maternal milk (for 21 days)
8food intake weight to change in body weight ratioBluHsd:LEmale6.9g/gcontrolled in utero environment (for 9 days) and bisphenol A (25 ug/kg) (for 30 days) then maternal milk (for 21 days)76207controlled in utero environment (for 9 days)bisphenol A (25 ug/kg) (for 30 days)maternal milk (for 21 days)
21number of blastocysts/embryos lost postimplantation to litter size ratioHanTac:WHfemale8%bisphenol A (0.025 mg/kg/d) (for 14 days)96589bisphenol A (0.025 mg/kg/d) (for 14 days)
18number of blastocysts/embryos lost postimplantation to litter size ratioHanTac:WHfemale5.9%bisphenol A (5 mg/kg/d) (for 14 days)96590bisphenol A (5 mg/kg/d) (for 14 days)
18number of blastocysts/embryos lost postimplantation to litter size ratioHanTac:WHfemale13%bisphenol A (50 mg/kg/d) (for 14 days)96591bisphenol A (50 mg/kg/d) (for 14 days)
18number of blastocysts/embryos lost postimplantation to litter size ratioHanTac:WHfemale7.9%vehicle control condition (for 14 days)96588vehicle control condition (for 14 days)
17number of blastocysts/embryos lost postimplantation to litter size ratioHanTac:WHfemale11.3%bisphenol A (0.25 mg/kg/d) (for 14 days)96587bisphenol A (0.25 mg/kg/d) (for 14 days)
9serum alanine aminotransferase activity levelF344/NHsdmale55U/lfasting (for 16 hours) then sodium chloride solution (for 4 hours)84711fasting (for 16 hours)sodium chloride solution (for 4 hours)
9serum alanine aminotransferase activity levelF344/NHsdmale54.5U/lfasting (for 16 hours) then sodium chloride solution (for 4 hours)84713fasting (for 16 hours)sodium chloride solution (for 4 hours)
5serum alanine aminotransferase activity levelF344/NHsdmale51U/lfasting (for 16 hours) then acetaminophen (800 mg/kg) (for 4 hours)84714fasting (for 16 hours)acetaminophen (800 mg/kg) (for 4 hours)
8serum alanine aminotransferase activity levelF344/NHsdmale109.3U/lfasting (for 16 hours) then acetaminophen (800 mg/kg) (for 4 hours)84712fasting (for 16 hours)acetaminophen (800 mg/kg) (for 4 hours)
9serum albumin levelF344/NHsdmale136g/dlfasting (for 16 hours) then sodium chloride solution (for 4 hours)84731fasting (for 16 hours)sodium chloride solution (for 4 hours)
8serum albumin levelF344/NHsdmale126g/dlfasting (for 16 hours) then acetaminophen (800 mg/kg) (for 4 hours)84732fasting (for 16 hours)acetaminophen (800 mg/kg) (for 4 hours)
9serum albumin levelF344/NHsdmale104g/dlfasting (for 16 hours) then sodium chloride solution (for 4 hours)84733fasting (for 16 hours)sodium chloride solution (for 4 hours)
5serum albumin levelF344/NHsdmale108g/dlfasting (for 16 hours) then acetaminophen (800 mg/kg) (for 4 hours)84734fasting (for 16 hours)acetaminophen (800 mg/kg) (for 4 hours)
6serum creatinine levelF344/NHsdmale0.37855mg/dlfasting (for 16 hours) then sodium chloride solution (for 4 hours)84739fasting (for 16 hours)sodium chloride solution (for 4 hours)
6serum creatinine levelF344/NHsdmale0.46556mg/dlfasting (for 16 hours) then acetaminophen (800 mg/kg) (for 4 hours)84740fasting (for 16 hours)acetaminophen (800 mg/kg) (for 4 hours)
7serum creatinine levelF344/NHsdmale0.3729mg/dlfasting (for 16 hours) then sodium chloride solution (for 4 hours)84741fasting (for 16 hours)sodium chloride solution (for 4 hours)
5serum creatinine levelF344/NHsdmale0.73902mg/dlfasting (for 16 hours) then acetaminophen (800 mg/kg) (for 4 hours)84742fasting (for 16 hours)acetaminophen (800 mg/kg) (for 4 hours)
9serum gamma-glutamyltransferase activity levelF344/NHsdmale1.2U/lfasting (for 16 hours) then sodium chloride solution (for 4 hours)84723fasting (for 16 hours)sodium chloride solution (for 4 hours)
8serum gamma-glutamyltransferase activity levelF344/NHsdmale1.6U/lfasting (for 16 hours) then acetaminophen (800 mg/kg) (for 4 hours)84724fasting (for 16 hours)acetaminophen (800 mg/kg) (for 4 hours)
9serum gamma-glutamyltransferase activity levelF344/NHsdmale2.1U/lfasting (for 16 hours) then sodium chloride solution (for 4 hours)84725fasting (for 16 hours)sodium chloride solution (for 4 hours)
5serum gamma-glutamyltransferase activity levelF344/NHsdmale1.2U/lfasting (for 16 hours) then acetaminophen (800 mg/kg) (for 4 hours)84726fasting (for 16 hours)acetaminophen (800 mg/kg) (for 4 hours)
9serum total protein levelF344/NHsdmale623g/dlfasting (for 16 hours) then sodium chloride solution (for 4 hours)84727fasting (for 16 hours)sodium chloride solution (for 4 hours)
8serum total protein levelF344/NHsdmale579g/dlfasting (for 16 hours) then acetaminophen (800 mg/kg) (for 4 hours)84728fasting (for 16 hours)acetaminophen (800 mg/kg) (for 4 hours)
9serum total protein levelF344/NHsdmale548g/dlfasting (for 16 hours) then sodium chloride solution (for 4 hours)84729fasting (for 16 hours)sodium chloride solution (for 4 hours)
5serum total protein levelF344/NHsdmale592g/dlfasting (for 16 hours) then acetaminophen (800 mg/kg) (for 4 hours)84730fasting (for 16 hours)acetaminophen (800 mg/kg) (for 4 hours)
9serum total bilirubin levelF344/NHsdmale5.8466mg/dlfasting (for 16 hours) then sodium chloride solution (for 4 hours)84735fasting (for 16 hours)sodium chloride solution (for 4 hours)
8serum total bilirubin levelF344/NHsdmale7.60058mg/dlfasting (for 16 hours) then acetaminophen (800 mg/kg) (for 4 hours)84736fasting (for 16 hours)acetaminophen (800 mg/kg) (for 4 hours)
9serum total bilirubin levelF344/NHsdmale14.6165mg/dlfasting (for 16 hours) then sodium chloride solution (for 4 hours)84737fasting (for 16 hours)sodium chloride solution (for 4 hours)
5serum total bilirubin levelF344/NHsdmale9.35456mg/dlfasting (for 16 hours) then acetaminophen (800 mg/kg) (for 4 hours)84738fasting (for 16 hours)acetaminophen (800 mg/kg) (for 4 hours)
9serum alkaline phosphatase activity levelF344/NHsdmale98.8U/lfasting (for 16 hours) then sodium chloride solution (for 4 hours)84719fasting (for 16 hours)sodium chloride solution (for 4 hours)
7serum alkaline phosphatase activity levelF344/NHsdmale85.3U/lfasting (for 16 hours) then acetaminophen (800 mg/kg) (for 4 hours)84720fasting (for 16 hours)acetaminophen (800 mg/kg) (for 4 hours)
9serum alkaline phosphatase activity levelF344/NHsdmale71.6U/lfasting (for 16 hours) then sodium chloride solution (for 4 hours)84721fasting (for 16 hours)sodium chloride solution (for 4 hours)
5serum alkaline phosphatase activity levelF344/NHsdmale48.2U/lfasting (for 16 hours) then acetaminophen (800 mg/kg) (for 4 hours)84722fasting (for 16 hours)acetaminophen (800 mg/kg) (for 4 hours)
5serum aspartate aminotransferase activity levelF344/NHsdmale194.6U/lfasting (for 16 hours) then acetaminophen (800 mg/kg) (for 4 hours)84718fasting (for 16 hours)acetaminophen (800 mg/kg) (for 4 hours)
9serum aspartate aminotransferase activity levelF344/NHsdmale112.4U/lfasting (for 16 hours) then sodium chloride solution (for 4 hours)84715fasting (for 16 hours)sodium chloride solution (for 4 hours)
7serum aspartate aminotransferase activity levelF344/NHsdmale349.6U/lfasting (for 16 hours) then acetaminophen (800 mg/kg) (for 4 hours)84716fasting (for 16 hours)acetaminophen (800 mg/kg) (for 4 hours)
6serum aspartate aminotransferase activity levelF344/NHsdmale120.8U/lfasting (for 16 hours) then sodium chloride solution (for 4 hours)84717fasting (for 16 hours)sodium chloride solution (for 4 hours)
6blood hemoglobin levelSDmale13.68g/dlacetaminophen (500 mg/kg) (for 28 days)84941acetaminophen (500 mg/kg) (for 28 days)
6blood hemoglobin levelSDmale13.98g/dlacetaminophen (1000 mg/kg) (for 28 days)84942acetaminophen (1000 mg/kg) (for 28 days)
6blood hemoglobin levelSDmale13.9g/dlcontrol condition84943control condition
6blood hemoglobin levelSDmale13.8g/dlcontrol condition84939control condition
6blood hemoglobin levelSDmale14.02g/dlacetaminophen (250 mg/kg) (for 28 days)84940acetaminophen (250 mg/kg) (for 28 days)
6blood hemoglobin levelSDfemale12.38g/dlacetaminophen (1000 mg/kg) (for 28 days)84950acetaminophen (1000 mg/kg) (for 28 days)
6blood hemoglobin levelSDmale13.75g/dlacetaminophen (1000 mg/kg) (for 28 days)84944acetaminophen (1000 mg/kg) (for 28 days)
6blood hemoglobin levelSDfemale11.28g/dlcontrol condition84945control condition
6blood hemoglobin levelSDfemale11.57g/dlacetaminophen (250 mg/kg) (for 28 days)84946acetaminophen (250 mg/kg) (for 28 days)
6blood hemoglobin levelSDfemale11.9g/dlacetaminophen (500 mg/kg) (for 28 days)84947acetaminophen (500 mg/kg) (for 28 days)
6blood hemoglobin levelSDfemale12.98g/dlacetaminophen (1000 mg/kg) (for 28 days)84948acetaminophen (1000 mg/kg) (for 28 days)
6blood hemoglobin levelSDfemale11.02g/dlcontrol condition84949control condition
6platelet countSDmale1095.83x 1000 cells/ulcontrol condition84975control condition
6platelet countSDmale1148.83x 1000 cells/ulacetaminophen (250 mg/kg) (for 28 days)84976acetaminophen (250 mg/kg) (for 28 days)
6platelet countSDmale1177.5x 1000 cells/ulacetaminophen (500 mg/kg) (for 28 days)84977acetaminophen (500 mg/kg) (for 28 days)
6platelet countSDmale1263x 1000 cells/ulacetaminophen (1000 mg/kg) (for 28 days)84978acetaminophen (1000 mg/kg) (for 28 days)
6platelet countSDmale1171x 1000 cells/ulcontrol condition84979control condition
6platelet countSDmale1122.17x 1000 cells/ulacetaminophen (1000 mg/kg) (for 28 days)84980acetaminophen (1000 mg/kg) (for 28 days)
6platelet countSDfemale816x 1000 cells/ulcontrol condition84981control condition
6platelet countSDfemale855.83x 1000 cells/ulacetaminophen (250 mg/kg) (for 28 days)84982acetaminophen (250 mg/kg) (for 28 days)
6platelet countSDfemale919x 1000 cells/ulacetaminophen (500 mg/kg) (for 28 days)84983acetaminophen (500 mg/kg) (for 28 days)
6platelet countSDfemale1025.83x 1000 cells/ulacetaminophen (1000 mg/kg) (for 28 days)84984acetaminophen (1000 mg/kg) (for 28 days)
6platelet countSDfemale846x 1000 cells/ulcontrol condition84985control condition
6platelet countSDfemale931x 1000 cells/ulacetaminophen (1000 mg/kg) (for 28 days)84986acetaminophen (1000 mg/kg) (for 28 days)
6blood differential white blood cell countSDfemale6.1x 1000 cells/ulcontrol condition84901control condition
6blood differential white blood cell countSDfemale8.83x 1000 cells/ulacetaminophen (250 mg/kg) (for 28 days)84902acetaminophen (250 mg/kg) (for 28 days)
6blood differential white blood cell countSDfemale8.81x 1000 cells/ulacetaminophen (500 mg/kg) (for 28 days)84904acetaminophen (500 mg/kg) (for 28 days)
6blood differential white blood cell countSDfemale9.48x 1000 cells/ulacetaminophen (1000 mg/kg) (for 28 days)84905acetaminophen (1000 mg/kg) (for 28 days)
6blood differential white blood cell countSDfemale8.24x 1000 cells/ulcontrol condition84906control condition
6blood differential white blood cell countSDfemale8.68x 1000 cells/ulacetaminophen (1000 mg/kg) (for 28 days)84907acetaminophen (1000 mg/kg) (for 28 days)
6blood differential white blood cell countSDmale6.56x 1000 cells/ulcontrol condition84885control condition
6blood differential white blood cell countSDmale11.3x 1000 cells/ulacetaminophen (250 mg/kg) (for 28 days)84887acetaminophen (250 mg/kg) (for 28 days)
6blood differential white blood cell countSDmale7.68x 1000 cells/ulacetaminophen (500 mg/kg) (for 28 days)84888acetaminophen (500 mg/kg) (for 28 days)
6blood differential white blood cell countSDmale7.58x 1000 cells/ulacetaminophen (1000 mg/kg) (for 28 days)84890acetaminophen (1000 mg/kg) (for 28 days)
6blood differential white blood cell countSDmale8.19x 1000 cells/ulcontrol condition84891control condition
6blood differential white blood cell countSDmale8.34x 1000 cells/ulacetaminophen (1000 mg/kg) (for 28 days)84893acetaminophen (1000 mg/kg) (for 28 days)
6red blood cell countSDmale8.31x 10E6 cells/ulcontrol condition84894control condition
6red blood cell countSDmale8.56x 10E6 cells/ulacetaminophen (250 mg/kg) (for 28 days)84895acetaminophen (250 mg/kg) (for 28 days)
6red blood cell countSDmale8.47x 10E6 cells/ulacetaminophen (500 mg/kg) (for 28 days)84896acetaminophen (500 mg/kg) (for 28 days)
6red blood cell countSDmale8.64x 10E6 cells/ulacetaminophen (1000 mg/kg) (for 28 days)84897acetaminophen (1000 mg/kg) (for 28 days)
6red blood cell countSDmale8.8x 10E6 cells/ulcontrol condition84898control condition
6red blood cell countSDmale8.64x 10E6 cells/ulacetaminophen (1000 mg/kg) (for 28 days)84899acetaminophen (1000 mg/kg) (for 28 days)
6red blood cell countSDfemale8.26x 10E6 cells/ulcontrol condition84908control condition
6red blood cell countSDfemale8.61x 10E6 cells/ulacetaminophen (250 mg/kg) (for 28 days)84909acetaminophen (250 mg/kg) (for 28 days)
6red blood cell countSDfemale8.93x 10E6 cells/ulacetaminophen (500 mg/kg) (for 28 days)84911acetaminophen (500 mg/kg) (for 28 days)
6red blood cell countSDfemale8.97x 10E6 cells/ulacetaminophen (1000 mg/kg) (for 28 days)84912acetaminophen (1000 mg/kg) (for 28 days)
6red blood cell countSDfemale8.77x 10E6 cells/ulcontrol condition84913control condition
6red blood cell countSDfemale8.97x 10E6 cells/ulacetaminophen (1000 mg/kg) (for 28 days)84914acetaminophen (1000 mg/kg) (for 28 days)
6hematocritSDmale45.25%control condition84951control condition
6hematocritSDmale44.38%acetaminophen (250 mg/kg) (for 28 days)84952acetaminophen (250 mg/kg) (for 28 days)
6hematocritSDmale44.05%acetaminophen (500 mg/kg) (for 28 days)84953acetaminophen (500 mg/kg) (for 28 days)
6hematocritSDmale45.1%acetaminophen (1000 mg/kg) (for 28 days)84954acetaminophen (1000 mg/kg) (for 28 days)
6hematocritSDmale45.68%control condition84955control condition
6hematocritSDmale45.18%acetaminophen (1000 mg/kg) (for 28 days)84956acetaminophen (1000 mg/kg) (for 28 days)
6hematocritSDfemale41.03%control condition84957control condition
6hematocritSDfemale40.22%acetaminophen (250 mg/kg) (for 28 days)84958acetaminophen (250 mg/kg) (for 28 days)
6hematocritSDfemale40.85%acetaminophen (500 mg/kg) (for 28 days)84959acetaminophen (500 mg/kg) (for 28 days)
6hematocritSDfemale41.85%acetaminophen (1000 mg/kg) (for 28 days)84960acetaminophen (1000 mg/kg) (for 28 days)
6hematocritSDfemale39.8%control condition84961control condition
6hematocritSDfemale41.5%acetaminophen (1000 mg/kg) (for 28 days)84962acetaminophen (1000 mg/kg) (for 28 days)
6food intake rateSDmale33.1g/dcontrol condition84824control condition
6food intake rateSDmale33.3g/dacetaminophen (500 mg/kg) (for 8 days)84832acetaminophen (500 mg/kg) (for 8 days)
6food intake rateSDmale36.7g/dacetaminophen (500 mg/kg) (for 15 days)84833acetaminophen (500 mg/kg) (for 15 days)
6food intake rateSDmale39.4g/dacetaminophen (500 mg/kg) (for 22 days)84834acetaminophen (500 mg/kg) (for 22 days)
6food intake rateSDmale31.7g/dacetaminophen (500 mg/kg) (for 28 days)84835acetaminophen (500 mg/kg) (for 28 days)
6food intake rateSDmale34.9g/dacetaminophen (1000 mg/kg) (for 8 days)84836acetaminophen (1000 mg/kg) (for 8 days)
6food intake rateSDmale35.1g/dacetaminophen (1000 mg/kg) (for 15 days)84837acetaminophen (1000 mg/kg) (for 15 days)
6food intake rateSDmale34.8g/dacetaminophen (1000 mg/kg) (for 22 days)84838acetaminophen (1000 mg/kg) (for 22 days)
6food intake rateSDmale31g/dacetaminophen (1000 mg/kg) (for 28 days)84839acetaminophen (1000 mg/kg) (for 28 days)
6food intake rateSDfemale23.1g/dcontrol condition84851control condition
6food intake rateSDfemale21.3g/dacetaminophen (250 mg/kg) (for 8 days)84852acetaminophen (250 mg/kg) (for 8 days)
6food intake rateSDfemale23g/dacetaminophen (250 mg/kg) (for 15 days)84853acetaminophen (250 mg/kg) (for 15 days)
6food intake rateSDfemale23.5g/dacetaminophen (250 mg/kg) (for 22 days)84854acetaminophen (250 mg/kg) (for 22 days)
6food intake rateSDfemale26g/dacetaminophen (250 mg/kg) (for 28 days)84855acetaminophen (250 mg/kg) (for 28 days)
6food intake rateSDfemale19.9g/dacetaminophen (500 mg/kg) (for 8 days)84856acetaminophen (500 mg/kg) (for 8 days)
6food intake rateSDfemale21.6g/dacetaminophen (500 mg/kg) (for 15 days)84857acetaminophen (500 mg/kg) (for 15 days)
6food intake rateSDfemale21.6g/dacetaminophen (500 mg/kg) (for 22 days)84858acetaminophen (500 mg/kg) (for 22 days)
6food intake rateSDfemale25.2g/dacetaminophen (1000 mg/kg) (for 15 days)84861acetaminophen (1000 mg/kg) (for 15 days)
6food intake rateSDfemale26.6g/dacetaminophen (1000 mg/kg) (for 22 days)84862acetaminophen (1000 mg/kg) (for 22 days)
6food intake rateSDfemale18.4g/dcontrol condition84864control condition
6food intake rateSDfemale21.4g/dcontrol condition84865control condition
6food intake rateSDfemale24.9g/dcontrol condition84866control condition
6food intake rateSDfemale20.4g/dcontrol condition84867control condition
6food intake rateSDfemale20g/dacetaminophen (1000 mg/kg) (for 15 days)84869acetaminophen (1000 mg/kg) (for 15 days)
6food intake rateSDfemale24.6g/dacetaminophen (1000 mg/kg) (for 22 days)84870acetaminophen (1000 mg/kg) (for 22 days)
6food intake rateSDmale35g/dcontrol condition84825control condition
6food intake rateSDmale35.8g/dcontrol condition84826control condition
6food intake rateSDmale31.9g/dcontrol condition84827control condition
6food intake rateSDmale32.5g/dacetaminophen (250 mg/kg) (for 8 days)84828acetaminophen (250 mg/kg) (for 8 days)
6food intake rateSDmale34.3g/dacetaminophen (250 mg/kg) (for 15 days)84829acetaminophen (250 mg/kg) (for 15 days)
6food intake rateSDmale32.4g/dacetaminophen (250 mg/kg) (for 28 days)84831acetaminophen (250 mg/kg) (for 28 days)
6food intake rateSDfemale25.7g/dacetaminophen (1000 mg/kg) (for 28 days)84863acetaminophen (1000 mg/kg) (for 28 days)
6food intake rateSDmale34.2g/dacetaminophen (250 mg/kg) (for 22 days)84830acetaminophen (250 mg/kg) (for 22 days)
6food intake rateSDmale33.5g/dcontrol condition84840control condition
6food intake rateSDmale34.5g/dcontrol condition84841control condition
6food intake rateSDmale33.7g/dcontrol condition84842control condition
6food intake rateSDmale27.9g/dcontrol condition84843control condition
6food intake rateSDmale39.5g/dacetaminophen (1000 mg/kg) (for 8 days)84844acetaminophen (1000 mg/kg) (for 8 days)
6food intake rateSDmale34.9g/dacetaminophen (1000 mg/kg) (for 15 days)84845acetaminophen (1000 mg/kg) (for 15 days)
6food intake rateSDmale39.4g/dacetaminophen (1000 mg/kg) (for 22 days)84846acetaminophen (1000 mg/kg) (for 22 days)
6food intake rateSDmale33.6g/dacetaminophen (1000 mg/kg) (for 28 days)84847acetaminophen (1000 mg/kg) (for 28 days)
6food intake rateSDfemale22.4g/dcontrol condition84848control condition
6food intake rateSDfemale21.9g/dcontrol condition84849control condition
6food intake rateSDfemale24.5g/dcontrol condition84850control condition
6food intake rateSDfemale24.6g/dacetaminophen (500 mg/kg) (for 28 days)84859acetaminophen (500 mg/kg) (for 28 days)
6food intake rateSDfemale21.8g/dacetaminophen (1000 mg/kg) (for 8 days)84860acetaminophen (1000 mg/kg) (for 8 days)
6food intake rateSDfemale18.5g/dacetaminophen (1000 mg/kg) (for 8 days)84868acetaminophen (1000 mg/kg) (for 8 days)
6food intake rateSDfemale21.8g/dacetaminophen (1000 mg/kg) (for 28 days)84871acetaminophen (1000 mg/kg) (for 28 days)
6red blood cell distribution width-coefficient of variationSDmale11.57%control condition84963control condition
6red blood cell distribution width-coefficient of variationSDmale12.35%acetaminophen (250 mg/kg) (for 28 days)84964acetaminophen (250 mg/kg) (for 28 days)
6red blood cell distribution width-coefficient of variationSDmale11.97%acetaminophen (500 mg/kg) (for 28 days)84965acetaminophen (500 mg/kg) (for 28 days)
6red blood cell distribution width-coefficient of variationSDmale11.87%acetaminophen (1000 mg/kg) (for 28 days)84966acetaminophen (1000 mg/kg) (for 28 days)
6red blood cell distribution width-coefficient of variationSDmale11.9%control condition84967control condition
6red blood cell distribution width-coefficient of variationSDmale11.73%acetaminophen (1000 mg/kg) (for 28 days)84968acetaminophen (1000 mg/kg) (for 28 days)
6red blood cell distribution width-coefficient of variationSDfemale10.98%control condition84969control condition
6red blood cell distribution width-coefficient of variationSDfemale11.38%acetaminophen (250 mg/kg) (for 28 days)84970acetaminophen (250 mg/kg) (for 28 days)
6red blood cell distribution width-coefficient of variationSDfemale12.62%acetaminophen (500 mg/kg) (for 28 days)84971acetaminophen (500 mg/kg) (for 28 days)
6red blood cell distribution width-coefficient of variationSDfemale11.13%acetaminophen (1000 mg/kg) (for 28 days)84972acetaminophen (1000 mg/kg) (for 28 days)
6red blood cell distribution width-coefficient of variationSDfemale11.32%control condition84973control condition
6red blood cell distribution width-coefficient of variationSDmale11.35%acetaminophen (1000 mg/kg) (for 28 days)84974acetaminophen (1000 mg/kg) (for 28 days)
10serum superoxide dismutase activity levelHsd:WInot specified5.5U/lfasting (for 16 hours)85606fasting (for 16 hours)
10serum superoxide dismutase activity levelHsd:WInot specified5.8U/lthymoquinone (15 mg/kg) (for 1 days) then fasting (for 16 hours)85607thymoquinone (15 mg/kg) (for 1 days)fasting (for 16 hours)
10serum superoxide dismutase activity levelHsd:WInot specified7.9U/lacetaminophen (500 mg/kg) (for 1 days) then fasting (for 16 hours)85608acetaminophen (500 mg/kg) (for 1 days)fasting (for 16 hours)
10serum superoxide dismutase activity levelHsd:WInot specified5.7U/lacetaminophen (500 mg/kg) (for 1 days) then thymoquinone (15 mg/kg) (for 1 days) then fasting (for 16 hours)85609acetaminophen (500 mg/kg) (for 1 days)thymoquinone (15 mg/kg) (for 1 days)fasting (for 16 hours)
6plasma glucose levelW/Ninmale99.54mg/dlcontrolled retinyl palmitate content diet (2.6 mg/kg) (between 36 and 42 days) then fasting (for 12 hours)96733controlled retinyl palmitate content diet (2.6 mg/kg) (between 36 and 42 days)fasting (for 12 hours)
6plasma glucose levelW/Ninmale99.54mg/dlcontrolled retinyl palmitate content diet (26 mg/kg) (between 36 and 42 days) then fasting (for 12 hours)96734controlled retinyl palmitate content diet (26 mg/kg) (between 36 and 42 days)fasting (for 12 hours)
6plasma glucose levelW/Ninmale105.48mg/dlcontrolled retinyl palmitate content diet (52 mg/kg) (between 36 and 42 days) then fasting (for 12 hours)96735controlled retinyl palmitate content diet (52 mg/kg) (between 36 and 42 days)fasting (for 12 hours)
6plasma glucose levelW/Ninmale96.66mg/dlcontrolled retinyl palmitate content diet (129 mg/kg) (between 36 and 42 days) then fasting (for 12 hours)96736controlled retinyl palmitate content diet (129 mg/kg) (between 36 and 42 days)fasting (for 12 hours)
6plasma glucose levelW-LeprfaNinmale126.36mg/dlcontrolled retinyl palmitate content diet (2.6 mg/kg) (between 36 and 42 days) then fasting (for 12 hours)96737controlled retinyl palmitate content diet (2.6 mg/kg) (between 36 and 42 days)fasting (for 12 hours)
6plasma glucose levelW-LeprfaNinmale112.68mg/dlcontrolled retinyl palmitate content diet (26 mg/kg) (between 36 and 42 days) then fasting (for 12 hours)96738controlled retinyl palmitate content diet (26 mg/kg) (between 36 and 42 days)fasting (for 12 hours)
6plasma glucose levelW-LeprfaNinmale132.12mg/dlcontrolled retinyl palmitate content diet (52 mg/kg) (between 36 and 42 days) then fasting (for 12 hours)96739controlled retinyl palmitate content diet (52 mg/kg) (between 36 and 42 days)fasting (for 12 hours)
6plasma glucose levelW-LeprfaNinmale137.7mg/dlcontrolled retinyl palmitate content diet (129 mg/kg) (between 36 and 42 days) then fasting (for 12 hours)96740controlled retinyl palmitate content diet (129 mg/kg) (between 36 and 42 days)fasting (for 12 hours)
6food intake rateW/Ninmale18.9g/dcontrolled retinyl palmitate content diet (2.6 mg/kg) (between 36 and 42 days) then fasting (for 12 hours)96725controlled retinyl palmitate content diet (2.6 mg/kg) (between 36 and 42 days)fasting (for 12 hours)
6food intake rateW/Ninmale17.4g/dcontrolled retinyl palmitate content diet (26 mg/kg) (between 36 and 42 days) then fasting (for 12 hours)96726controlled retinyl palmitate content diet (26 mg/kg) (between 36 and 42 days)fasting (for 12 hours)
6food intake rateW/Ninmale19.4g/dcontrolled retinyl palmitate content diet (52 mg/kg) (between 36 and 42 days) then fasting (for 12 hours)96727controlled retinyl palmitate content diet (52 mg/kg) (between 36 and 42 days)fasting (for 12 hours)
6food intake rateW/Ninmale18.8g/dcontrolled retinyl palmitate content diet (129 mg/kg) (between 36 and 42 days) then fasting (for 12 hours)96728controlled retinyl palmitate content diet (129 mg/kg) (between 36 and 42 days)fasting (for 12 hours)
6food intake rateW-LeprfaNinmale27.9g/dcontrolled retinyl palmitate content diet (2.6 mg/kg) (between 36 and 42 days) then fasting (for 12 hours)96729controlled retinyl palmitate content diet (2.6 mg/kg) (between 36 and 42 days)fasting (for 12 hours)
6food intake rateW-LeprfaNinmale29.3g/dcontrolled retinyl palmitate content diet (26 mg/kg) (between 36 and 42 days) then fasting (for 12 hours)96730controlled retinyl palmitate content diet (26 mg/kg) (between 36 and 42 days)fasting (for 12 hours)
6food intake rateW-LeprfaNinmale28.1g/dcontrolled retinyl palmitate content diet (52 mg/kg) (between 36 and 42 days) then fasting (for 12 hours)96731controlled retinyl palmitate content diet (52 mg/kg) (between 36 and 42 days)fasting (for 12 hours)
6food intake rateW-LeprfaNinmale26.8g/dcontrolled retinyl palmitate content diet (129 mg/kg) (between 36 and 42 days) then fasting (for 12 hours)96732controlled retinyl palmitate content diet (129 mg/kg) (between 36 and 42 days)fasting (for 12 hours)
6plasma retinol levelW/Ninmale28ug/dlcontrolled retinyl palmitate content diet (2.6 mg/kg) (between 36 and 42 days) then fasting (for 12 hours)96741controlled retinyl palmitate content diet (2.6 mg/kg) (between 36 and 42 days)fasting (for 12 hours)
6plasma retinol levelW/Ninmale28ug/dlcontrolled retinyl palmitate content diet (26 mg/kg) (between 36 and 42 days) then fasting (for 12 hours)96742controlled retinyl palmitate content diet (26 mg/kg) (between 36 and 42 days)fasting (for 12 hours)
6plasma retinol levelW/Ninmale26ug/dlcontrolled retinyl palmitate content diet (52 mg/kg) (between 36 and 42 days) then fasting (for 12 hours)96743controlled retinyl palmitate content diet (52 mg/kg) (between 36 and 42 days)fasting (for 12 hours)
6plasma retinol levelW/Ninmale29ug/dlcontrolled retinyl palmitate content diet (129 mg/kg) (between 36 and 42 days) then fasting (for 12 hours)96744controlled retinyl palmitate content diet (129 mg/kg) (between 36 and 42 days)fasting (for 12 hours)
6plasma retinol levelW-LeprfaNinmale40ug/dlcontrolled retinyl palmitate content diet (2.6 mg/kg) (between 36 and 42 days) then fasting (for 12 hours)96745controlled retinyl palmitate content diet (2.6 mg/kg) (between 36 and 42 days)fasting (for 12 hours)
6plasma retinol levelW-LeprfaNinmale41ug/dlcontrolled retinyl palmitate content diet (26 mg/kg) (between 36 and 42 days) then fasting (for 12 hours)96746controlled retinyl palmitate content diet (26 mg/kg) (between 36 and 42 days)fasting (for 12 hours)
6plasma retinol levelW-LeprfaNinmale46ug/dlcontrolled retinyl palmitate content diet (52 mg/kg) (between 36 and 42 days) then fasting (for 12 hours)96747controlled retinyl palmitate content diet (52 mg/kg) (between 36 and 42 days)fasting (for 12 hours)
6plasma retinol levelW-LeprfaNinmale43ug/dlcontrolled retinyl palmitate content diet (129 mg/kg) (between 36 and 42 days) then fasting (for 12 hours)96748controlled retinyl palmitate content diet (129 mg/kg) (between 36 and 42 days)fasting (for 12 hours)
10bone ash contentY59/Zgdfemale0.59gnaringenin (100 mg/kg/d) (for 14 days)97415naringenin (100 mg/kg/d) (for 14 days)
10bone ash contentY59/Zgdfemale0.62gethanol (0.5 %) (for 14 days)97397ethanol (0.5 %) (for 14 days)
10bone ash contentY59/Zgdfemale0.58galendronate (40 mg/kg/d) (for 14 days)97412alendronate (40 mg/kg/d) (for 14 days)
10bone ash contentY59/Zgdfemale0.64gvitamin A (80 mg/kg/d) (for 14 days)97402vitamin A (80 mg/kg/d) (for 14 days)
10bone ash contentY59/Zgdfemale0.65gvitamin A (80 mg/kg/d) (for 14 days) and alendronate (40 mg/kg/d) (for 14 days)97404vitamin A (80 mg/kg/d) (for 14 days)alendronate (40 mg/kg/d) (for 14 days)
10bone ash contentY59/Zgdfemale0.82gvitamin A (80 mg/kg/d) (for 14 days) and quercetin (100 mg/kg/d) (for 14 days)97408vitamin A (80 mg/kg/d) (for 14 days)quercetin (100 mg/kg/d) (for 14 days)
10bone ash contentY59/Zgdfemale0.75gvitamin A (80 mg/kg/d) (for 14 days) and chrysin (100 mg/kg/d) (for 14 days)97409vitamin A (80 mg/kg/d) (for 14 days)chrysin (100 mg/kg/d) (for 14 days)
10bone ash contentY59/Zgdfemale0.75gvitamin A (80 mg/kg/d) (for 14 days) and naringenin (100 mg/kg/d) (for 14 days)97410vitamin A (80 mg/kg/d) (for 14 days)naringenin (100 mg/kg/d) (for 14 days)
10bone ash contentY59/Zgdfemale0.63gethanol (0.5 %) (for 14 days)97411ethanol (0.5 %) (for 14 days)
10bone ash contentY59/Zgdfemale0.59gchrysin (100 mg/kg/d) (for 14 days)97414chrysin (100 mg/kg/d) (for 14 days)
10bone ash contentY59/Zgdfemale0.67gquercetin (100 mg/kg/d) (for 14 days)97413quercetin (100 mg/kg/d) (for 14 days)
7artery wall thickness to artery inner diameter ratioSS-Chr 12BN/Mcwimale22.7%controlled sodium content diet (0.3 %) then controlled ex vivo artery perfusion pressure (20 mmHg) 96873controlled sodium content diet (0.3 %) controlled ex vivo artery perfusion pressure (20 mmHg)
7artery wall thickness to artery inner diameter ratioSS-Chr 12BN/Mcwimale17.2%controlled sodium content diet (0.3 %) then controlled ex vivo artery perfusion pressure (40 mmHg) 96874controlled sodium content diet (0.3 %) controlled ex vivo artery perfusion pressure (40 mmHg)
7artery wall thickness to artery inner diameter ratioSS-Chr 12BN/Mcwimale13.8%controlled sodium content diet (0.3 %) then controlled ex vivo artery perfusion pressure (60 mmHg) 96875controlled sodium content diet (0.3 %) controlled ex vivo artery perfusion pressure (60 mmHg)
7artery wall thickness to artery inner diameter ratioSS-Chr 12BN/Mcwimale10.8%controlled sodium content diet (0.3 %) then controlled ex vivo artery perfusion pressure (80 mmHg) 96876controlled sodium content diet (0.3 %) controlled ex vivo artery perfusion pressure (80 mmHg)
7artery wall thickness to artery inner diameter ratioSS-Chr 12BN/Mcwimale9.4%controlled sodium content diet (0.3 %) then controlled ex vivo artery perfusion pressure (100 mmHg) 96877controlled sodium content diet (0.3 %) controlled ex vivo artery perfusion pressure (100 mmHg)
7artery wall thickness to artery inner diameter ratioSS-Chr 12BN/Mcwimale8.7%controlled sodium content diet (0.3 %) then controlled ex vivo artery perfusion pressure (120 mmHg) 96878controlled sodium content diet (0.3 %) controlled ex vivo artery perfusion pressure (120 mmHg)
7artery wall thickness to artery inner diameter ratioSS-Chr 12BN/Mcwimale7.8%controlled sodium content diet (0.3 %) then controlled ex vivo artery perfusion pressure (140 mmHg) 96879controlled sodium content diet (0.3 %) controlled ex vivo artery perfusion pressure (140 mmHg)
5artery wall thickness to artery inner diameter ratioSS-Chr 12BN.SS-(D12Hmgc3-D12Hmgc6)/Mcwimale20.5%controlled sodium content diet (0.3 %) then controlled ex vivo artery perfusion pressure (20 mmHg) 96881controlled sodium content diet (0.3 %) controlled ex vivo artery perfusion pressure (20 mmHg)
5artery wall thickness to artery inner diameter ratioSS-Chr 12BN.SS-(D12Hmgc3-D12Hmgc6)/Mcwimale15.6%controlled sodium content diet (0.3 %) then controlled ex vivo artery perfusion pressure (40 mmHg) 96882controlled sodium content diet (0.3 %) controlled ex vivo artery perfusion pressure (40 mmHg)
5artery wall thickness to artery inner diameter ratioSS-Chr 12BN.SS-(D12Hmgc3-D12Hmgc6)/Mcwimale12.1%controlled sodium content diet (0.3 %) then controlled ex vivo artery perfusion pressure (60 mmHg) 96883controlled sodium content diet (0.3 %) controlled ex vivo artery perfusion pressure (60 mmHg)
5artery wall thickness to artery inner diameter ratioSS-Chr 12BN.SS-(D12Hmgc3-D12Hmgc6)/Mcwimale9%controlled sodium content diet (0.3 %) then controlled ex vivo artery perfusion pressure (80 mmHg) 96884controlled sodium content diet (0.3 %) controlled ex vivo artery perfusion pressure (80 mmHg)
5artery wall thickness to artery inner diameter ratioSS-Chr 12BN.SS-(D12Hmgc3-D12Hmgc6)/Mcwimale7.6%controlled sodium content diet (0.3 %) then controlled ex vivo artery perfusion pressure (100 mmHg) 96885controlled sodium content diet (0.3 %) controlled ex vivo artery perfusion pressure (100 mmHg)
5artery wall thickness to artery inner diameter ratioSS-Chr 12BN.SS-(D12Hmgc3-D12Hmgc6)/Mcwimale7%controlled sodium content diet (0.3 %) then controlled ex vivo artery perfusion pressure (120 mmHg) 96886controlled sodium content diet (0.3 %) controlled ex vivo artery perfusion pressure (120 mmHg)
5artery wall thickness to artery inner diameter ratioSS-Chr 12BN.SS-(D12Hmgc3-D12Hmgc6)/Mcwimale6.5%controlled sodium content diet (0.3 %) then controlled ex vivo artery perfusion pressure (140 mmHg) 96887controlled sodium content diet (0.3 %) controlled ex vivo artery perfusion pressure (140 mmHg)
5artery wall thickness to artery inner diameter ratioSS-Chr 12BN.SS-(D12Hmgc3-D12Hmgc6)/Mcwimale6.3%controlled sodium content diet (0.3 %) then controlled ex vivo artery perfusion pressure (160 mmHg) 96888controlled sodium content diet (0.3 %) controlled ex vivo artery perfusion pressure (160 mmHg)
12artery wall thickness to artery inner diameter ratioSS.BN-(D12Hmgc3-AU047911)/Mcwimale21%controlled sodium content diet (0.3 %) then controlled ex vivo artery perfusion pressure (20 mmHg) 96889controlled sodium content diet (0.3 %) controlled ex vivo artery perfusion pressure (20 mmHg)
12artery wall thickness to artery inner diameter ratioSS.BN-(D12Hmgc3-AU047911)/Mcwimale15.7%controlled sodium content diet (0.3 %) then controlled ex vivo artery perfusion pressure (40 mmHg) 96890controlled sodium content diet (0.3 %) controlled ex vivo artery perfusion pressure (40 mmHg)
12artery wall thickness to artery inner diameter ratioSS.BN-(D12Hmgc3-AU047911)/Mcwimale12.2%controlled sodium content diet (0.3 %) then controlled ex vivo artery perfusion pressure (60 mmHg) 96891controlled sodium content diet (0.3 %) controlled ex vivo artery perfusion pressure (60 mmHg)
12artery wall thickness to artery inner diameter ratioSS.BN-(D12Hmgc3-AU047911)/Mcwimale9.5%controlled sodium content diet (0.3 %) then controlled ex vivo artery perfusion pressure (80 mmHg) 96892controlled sodium content diet (0.3 %) controlled ex vivo artery perfusion pressure (80 mmHg)
12artery wall thickness to artery inner diameter ratioSS.BN-(D12Hmgc3-AU047911)/Mcwimale8.6%controlled sodium content diet (0.3 %) then controlled ex vivo artery perfusion pressure (100 mmHg) 96893controlled sodium content diet (0.3 %) controlled ex vivo artery perfusion pressure (100 mmHg)
12artery wall thickness to artery inner diameter ratioSS.BN-(D12Hmgc3-AU047911)/Mcwimale8%controlled sodium content diet (0.3 %) then controlled ex vivo artery perfusion pressure (120 mmHg) 96894controlled sodium content diet (0.3 %) controlled ex vivo artery perfusion pressure (120 mmHg)
12artery wall thickness to artery inner diameter ratioSS.BN-(D12Hmgc3-AU047911)/Mcwimale7.5%controlled sodium content diet (0.3 %) then controlled ex vivo artery perfusion pressure (140 mmHg) 96895controlled sodium content diet (0.3 %) controlled ex vivo artery perfusion pressure (140 mmHg)
12artery wall thickness to artery inner diameter ratioSS.BN-(D12Hmgc3-AU047911)/Mcwimale7.3%controlled sodium content diet (0.3 %) then controlled ex vivo artery perfusion pressure (160 mmHg) 96896controlled sodium content diet (0.3 %) controlled ex vivo artery perfusion pressure (160 mmHg)
7artery wall thickness to artery inner diameter ratioSS-Chr 12BN/Mcwimale7.6%controlled sodium content diet (0.3 %) then controlled ex vivo artery perfusion pressure (160 mmHg) 96880controlled sodium content diet (0.3 %) controlled ex vivo artery perfusion pressure (160 mmHg)
8food intake rateCrl:CD(SD)male24.5g/dstandard diet then acetaminophen (300 mg/kg) (for 35 days)85465standard dietacetaminophen (300 mg/kg) (for 35 days)
8food intake rateCrl:CD(SD)male25.7g/dstandard diet then acetaminophen (500 mg/kg) (for 35 days)85466standard dietacetaminophen (500 mg/kg) (for 35 days)
8food intake rateCrl:CD(SD)male24.6g/dstandard diet then acetaminophen (300 mg/kg) (for 56 days)85471standard dietacetaminophen (300 mg/kg) (for 56 days)
8food intake rateCrl:CD(SD)male24.5g/dstandard diet then acetaminophen (500 mg/kg) (for 77 days)85478standard dietacetaminophen (500 mg/kg) (for 77 days)
8food intake rateCrl:CD(SD)male17.9g/dstandard diet and restricted feeding (4 h) then acetaminophen (300 mg/kg) (for 77 days)85480standard dietrestricted feeding (4 h) acetaminophen (300 mg/kg) (for 77 days)
8food intake rateCrl:CD(SD)male16.6g/dstandard diet and restricted feeding (4 h) then acetaminophen (500 mg/kg) (for 98 days)85487standard dietrestricted feeding (4 h) acetaminophen (500 mg/kg) (for 98 days)
8food intake weight to body weight ratioCrl:CD(SD)male6.04g/d/100gstandard diet and restricted feeding (4 h) then acetaminophen (500 mg/kg) (for 14 days)85493standard dietrestricted feeding (4 h) acetaminophen (500 mg/kg) (for 14 days)
8food intake weight to body weight ratioCrl:CD(SD)male4.37g/d/100gstandard diet and restricted feeding (4 h) then acetaminophen (300 mg/kg) (for 77 days)85510standard dietrestricted feeding (4 h) acetaminophen (300 mg/kg) (for 77 days)
8food intake weight to body weight ratioCrl:CD(SD)male3.96g/d/100gstandard diet and restricted feeding (4 h) then acetaminophen (300 mg/kg) (for 98 days)85516standard dietrestricted feeding (4 h) acetaminophen (300 mg/kg) (for 98 days)
19food intake rateCrl:CD(SD)male17g/dstandard diet and restricted feeding (4 h) 85292standard dietrestricted feeding (4 h)
19food intake rateCrl:CD(SD)male17.2g/dstandard diet and restricted feeding (4 h) 85293standard dietrestricted feeding (4 h)
19food intake rateCrl:CD(SD)male20.1g/dstandard diet and restricted feeding (4 h) 85295standard dietrestricted feeding (4 h)
19food intake rateCrl:CD(SD)male19.4g/dstandard diet and restricted feeding (4 h) 85297standard dietrestricted feeding (4 h)
19food intake rateCrl:CD(SD)male23.7g/dstandard diet85298standard diet
19food intake rateCrl:CD(SD)male17.2g/dstandard diet and restricted feeding (4 h) 85299standard dietrestricted feeding (4 h)
19food intake weight to body weight ratioCrl:CD(SD)male5.78g/d/100gstandard diet85300standard diet
19food intake weight to body weight ratioCrl:CD(SD)male5.28g/d/100gstandard diet85302standard diet
19food intake weight to body weight ratioCrl:CD(SD)male5.36g/d/100gstandard diet and restricted feeding (4 h) 85303standard dietrestricted feeding (4 h)
19food intake weight to body weight ratioCrl:CD(SD)male4.74g/d/100gstandard diet85304standard diet
19food intake weight to body weight ratioCrl:CD(SD)male4.62g/d/100gstandard diet and restricted feeding (4 h) 85305standard dietrestricted feeding (4 h)
19food intake weight to body weight ratioCrl:CD(SD)male4.44g/d/100gstandard diet85306standard diet
8food intake rateCrl:CD(SD)male24.1g/dstandard diet then acetaminophen (300 mg/kg) (for 14 days)85459standard dietacetaminophen (300 mg/kg) (for 14 days)
8food intake rateCrl:CD(SD)male24.7g/dstandard diet then acetaminophen (500 mg/kg) (for 14 days)85460standard dietacetaminophen (500 mg/kg) (for 14 days)
8food intake rateCrl:CD(SD)male20.3g/dstandard diet and restricted feeding (4 h) then acetaminophen (300 mg/kg) (for 14 days)85462standard dietrestricted feeding (4 h) acetaminophen (300 mg/kg) (for 14 days)
8food intake rateCrl:CD(SD)male18.8g/dstandard diet and restricted feeding (4 h) then acetaminophen (500 mg/kg) (for 14 days)85463standard dietrestricted feeding (4 h) acetaminophen (500 mg/kg) (for 14 days)
8food intake rateCrl:CD(SD)male18.2g/dstandard diet and restricted feeding (4 h) then acetaminophen (300 mg/kg) (for 35 days)85468standard dietrestricted feeding (4 h) acetaminophen (300 mg/kg) (for 35 days)
8food intake rateCrl:CD(SD)male17.7g/dstandard diet and restricted feeding (4 h) then acetaminophen (500 mg/kg) (for 77 days)85481standard dietrestricted feeding (4 h) acetaminophen (500 mg/kg) (for 77 days)
8food intake rateCrl:CD(SD)male23.4g/dstandard diet then acetaminophen (300 mg/kg) (for 98 days)85483standard dietacetaminophen (300 mg/kg) (for 98 days)
8food intake rateCrl:CD(SD)male22.8g/dstandard diet then acetaminophen (500 mg/kg) (for 98 days)85484standard dietacetaminophen (500 mg/kg) (for 98 days)
8food intake rateCrl:CD(SD)male18.3g/dstandard diet and restricted feeding (4 h) then acetaminophen (300 mg/kg) (for 98 days)85486standard dietrestricted feeding (4 h) acetaminophen (300 mg/kg) (for 98 days)
8food intake weight to body weight ratioCrl:CD(SD)male5.74g/d/100gstandard diet then acetaminophen (300 mg/kg) (for 14 days)85489standard dietacetaminophen (300 mg/kg) (for 14 days)
8food intake weight to body weight ratioCrl:CD(SD)male5.68g/d/100gstandard diet then acetaminophen (500 mg/kg) (for 14 days)85490standard dietacetaminophen (500 mg/kg) (for 14 days)
8food intake weight to body weight ratioCrl:CD(SD)male5.2g/d/100gstandard diet then acetaminophen (300 mg/kg) (for 35 days)85495standard dietacetaminophen (300 mg/kg) (for 35 days)
8food intake weight to body weight ratioCrl:CD(SD)male5.12g/d/100gstandard diet then acetaminophen (500 mg/kg) (for 35 days)85496standard dietacetaminophen (500 mg/kg) (for 35 days)
8food intake weight to body weight ratioCrl:CD(SD)male5.09g/d/100gstandard diet and restricted feeding (4 h) then acetaminophen (300 mg/kg) (for 35 days)85498standard dietrestricted feeding (4 h) acetaminophen (300 mg/kg) (for 35 days)
8food intake weight to body weight ratioCrl:CD(SD)male4.7g/d/100gstandard diet then acetaminophen (300 mg/kg) (for 56 days)85501standard dietacetaminophen (300 mg/kg) (for 56 days)
8food intake weight to body weight ratioCrl:CD(SD)male4.53g/d/100gstandard diet then acetaminophen (500 mg/kg) (for 56 days)85502standard dietacetaminophen (500 mg/kg) (for 56 days)
8food intake weight to body weight ratioCrl:CD(SD)male4.38g/d/100gstandard diet and restricted feeding (4 h) then acetaminophen (300 mg/kg) (for 56 days)85504standard dietrestricted feeding (4 h) acetaminophen (300 mg/kg) (for 56 days)
8food intake weight to body weight ratioCrl:CD(SD)male4.23g/d/100gstandard diet and restricted feeding (4 h) then acetaminophen (500 mg/kg) (for 56 days)85505standard dietrestricted feeding (4 h) acetaminophen (500 mg/kg) (for 56 days)
8food intake weight to body weight ratioCrl:CD(SD)male4.09g/d/100gstandard diet then acetaminophen (300 mg/kg) (for 77 days)85507standard dietacetaminophen (300 mg/kg) (for 77 days)
8food intake weight to body weight ratioCrl:CD(SD)male4.49g/d/100gstandard diet then acetaminophen (500 mg/kg) (for 77 days)85508standard dietacetaminophen (500 mg/kg) (for 77 days)
8food intake weight to body weight ratioCrl:CD(SD)male4.05g/d/100gstandard diet then acetaminophen (300 mg/kg) (for 98 days)85513standard dietacetaminophen (300 mg/kg) (for 98 days)
19food intake rateCrl:CD(SD)male24.7g/dstandard diet85290standard diet
19food intake weight to body weight ratioCrl:CD(SD)male6.11g/d/100gstandard diet and restricted feeding (4 h) 85301standard dietrestricted feeding (4 h)
19food intake weight to body weight ratioCrl:CD(SD)male4.18g/d/100gstandard diet and restricted feeding (4 h) 85307standard dietrestricted feeding (4 h)
19food intake weight to body weight ratioCrl:CD(SD)male4.07g/d/100gstandard diet85308standard diet
19food intake weight to body weight ratioCrl:CD(SD)male4.01g/d/100gstandard diet and restricted feeding (4 h) 85309standard dietrestricted feeding (4 h)
19food intake rateCrl:CD(SD)male24.5g/dstandard diet85291standard diet
19food intake rateCrl:CD(SD)male24.8g/dstandard diet85294standard diet
19food intake rateCrl:CD(SD)male23.9g/dstandard diet85296standard diet
8food intake rateCrl:CD(SD)male24.9g/dstandard diet then acetaminophen (500 mg/kg) (for 56 days)85472standard dietacetaminophen (500 mg/kg) (for 56 days)
8food intake rateCrl:CD(SD)male22.1g/dstandard diet and restricted feeding (4 h) then acetaminophen (300 mg/kg) (for 56 days)85474standard dietrestricted feeding (4 h) acetaminophen (300 mg/kg) (for 56 days)
8food intake rateCrl:CD(SD)male18.7g/dstandard diet and restricted feeding (4 h) then acetaminophen (500 mg/kg) (for 56 days)85475standard dietrestricted feeding (4 h) acetaminophen (500 mg/kg) (for 56 days)
8food intake weight to body weight ratioCrl:CD(SD)male4.03g/d/100gstandard diet and restricted feeding (4 h) then acetaminophen (500 mg/kg) (for 77 days)85511standard dietrestricted feeding (4 h) acetaminophen (500 mg/kg) (for 77 days)
8food intake rateCrl:CD(SD)male16.7g/dstandard diet and restricted feeding (4 h) then acetaminophen (500 mg/kg) (for 35 days)85469standard dietrestricted feeding (4 h) acetaminophen (500 mg/kg) (for 35 days)
8food intake rateCrl:CD(SD)male24.3g/dstandard diet then acetaminophen (300 mg/kg) (for 77 days)85477standard dietacetaminophen (300 mg/kg) (for 77 days)
8food intake weight to body weight ratioCrl:CD(SD)male6.04g/d/100gstandard diet and restricted feeding (4 h) then acetaminophen (300 mg/kg) (for 14 days)85492standard dietrestricted feeding (4 h) acetaminophen (300 mg/kg) (for 14 days)
8food intake weight to body weight ratioCrl:CD(SD)male4.9g/d/100gstandard diet and restricted feeding (4 h) then acetaminophen (500 mg/kg) (for 35 days)85499standard dietrestricted feeding (4 h) acetaminophen (500 mg/kg) (for 35 days)
8food intake weight to body weight ratioCrl:CD(SD)male4.24g/d/100gstandard diet then acetaminophen (500 mg/kg) (for 98 days)85514standard dietacetaminophen (500 mg/kg) (for 98 days)
8food intake weight to body weight ratioCrl:CD(SD)male4.34g/d/100gstandard diet and restricted feeding (4 h) then acetaminophen (500 mg/kg) (for 98 days)85517standard dietrestricted feeding (4 h) acetaminophen (500 mg/kg) (for 98 days)
8liver wet weightCrl:CD(SD)male20.3gstandard diet then acetaminophen (500 mg/kg) (for 99 days)85556standard dietacetaminophen (500 mg/kg) (for 99 days)
8liver wet weightCrl:CD(SD)male20.1gstandard diet then acetaminophen (300 mg/kg) (for 99 days)85555standard dietacetaminophen (300 mg/kg) (for 99 days)
8liver wet weightCrl:CD(SD)male12.8gstandard diet and restricted feeding (4 h) (for 114 days) then acetaminophen (500 mg/kg) (for 99 days) then fasting (for 20 hours)85559standard dietrestricted feeding (4 h) (for 114 days)acetaminophen (500 mg/kg) (for 99 days)fasting (for 20 hours)
19liver wet weightCrl:CD(SD)male17.65gstandard diet85402standard diet
19liver wet weightCrl:CD(SD)male11.09gstandard diet and restricted feeding (4 h) (for 114 days) then fasting (for 20 hours)85403standard dietrestricted feeding (4 h) (for 114 days)fasting (for 20 hours)
8liver wet weightCrl:CD(SD)male12.2gstandard diet and restricted feeding (4 h) (for 114 days) then acetaminophen (300 mg/kg) (for 99 days) then fasting (for 20 hours)85558standard dietrestricted feeding (4 h) (for 114 days)acetaminophen (300 mg/kg) (for 99 days)fasting (for 20 hours)
9water drink intake rateCrl:SDmale39ml/dcontrolled fructose content diet (66 %) (between 14 and 28 days)75863controlled fructose content diet (66 %) (between 14 and 28 days)
8water drink intake rateCrl:SDmale43ml/dcontrol condition75864control condition
10metformin drink intake rateCrl:SDmale35ml/dcontrolled metformin content drinking water (350-500 mg/kg/d) (between 21 and 35 days) then controlled fructose content diet (66 %) (between 14 and 28 days)75865controlled metformin content drinking water (350-500 mg/kg/d) (between 21 and 35 days)controlled fructose content diet (66 %) (between 14 and 28 days)
8metformin drink intake rateCrl:SDmale37ml/dcontrolled metformin content drinking water (350-500 mg/kg/d) (between 21 and 35 days)75866controlled metformin content drinking water (350-500 mg/kg/d) (between 21 and 35 days)
9water drink intake rateCrl:SDmale34ml/dcontrolled fructose content diet (66 %) 75867controlled fructose content diet (66 %)
8water drink intake rateCrl:SDmale35ml/dcontrol condition75868control condition
10metformin drink intake rateCrl:SDmale33ml/dcontrolled metformin content drinking water (350-500 mg/kg/d) then controlled fructose content diet (66 %) 75869controlled metformin content drinking water (350-500 mg/kg/d) controlled fructose content diet (66 %)
8metformin drink intake rateCrl:SDmale31ml/dcontrolled metformin content drinking water (350-500 mg/kg/d) 75870controlled metformin content drinking water (350-500 mg/kg/d)
9food intake rateCrl:SDmale26g/dcontrolled fructose content diet (66 %) (between 14 and 28 days)75871controlled fructose content diet (66 %) (between 14 and 28 days)
8food intake rateCrl:SDmale28g/dcontrol condition75872control condition
10food intake rateCrl:SDmale24g/dcontrolled metformin content drinking water (350-500 mg/kg/d) (between 21 and 35 days) then controlled fructose content diet (66 %) (between 14 and 28 days)75873controlled metformin content drinking water (350-500 mg/kg/d) (between 21 and 35 days)controlled fructose content diet (66 %) (between 14 and 28 days)
8food intake rateCrl:SDmale24g/dcontrolled metformin content drinking water (350-500 mg/kg/d) (between 21 and 35 days)75874controlled metformin content drinking water (350-500 mg/kg/d) (between 21 and 35 days)
9food intake rateCrl:SDmale19g/dcontrolled fructose content diet (66 %) 75875controlled fructose content diet (66 %)
8food intake rateCrl:SDmale18g/dcontrol condition75876control condition
10food intake rateCrl:SDmale18g/dcontrolled metformin content drinking water (350-500 mg/kg/d) then controlled fructose content diet (66 %) 75877controlled metformin content drinking water (350-500 mg/kg/d) controlled fructose content diet (66 %)
8food intake rateCrl:SDmale17g/dcontrolled metformin content drinking water (350-500 mg/kg/d) 75878controlled metformin content drinking water (350-500 mg/kg/d)
6water drink intake rateCrljJcl:SDfemale59.93ml/dgestation (for 20 days)75882gestation (for 20 days)
6water drink intake rateCrljJcl:SDfemale77.08ml/dgestation (for 21 days) then lactation (for 7 days)75883gestation (for 21 days)lactation (for 7 days)
6water drink intake rateCrljJcl:SDfemale97.33ml/dgestation (for 21 days) then lactation (for 14 days)75884gestation (for 21 days)lactation (for 14 days)
6water drink intake rateCrljJcl:SDfemale128.6ml/dgestation (for 21 days) then lactation (for 21 days)75885gestation (for 21 days)lactation (for 21 days)
6water drink intake rateCrljJcl:SDfemale45.01ml/dgestation (for 14 days)75881gestation (for 14 days)
8bisphenol A drink intake rateCrljJcl:SDfemale47.35ml/dgestation (for 14 days) then controlled bisphenol A content drinking water (0.01 mg/l) (for 3 days)75886gestation (for 14 days)controlled bisphenol A content drinking water (0.01 mg/l) (for 3 days)
8bisphenol A drink intake rateCrljJcl:SDfemale56.77ml/dgestation (for 20 days) then controlled bisphenol A content drinking water (0.01 mg/l) (for 9 days)75887gestation (for 20 days)controlled bisphenol A content drinking water (0.01 mg/l) (for 9 days)
8bisphenol A drink intake rateCrljJcl:SDfemale73.26ml/dgestation (for 21 days) then controlled bisphenol A content drinking water (0.01 mg/l) (for 17 days) then lactation (for 7 days)75888gestation (for 21 days)controlled bisphenol A content drinking water (0.01 mg/l) (for 17 days)lactation (for 7 days)
8bisphenol A drink intake rateCrljJcl:SDfemale99.93ml/dgestation (for 21 days) then controlled bisphenol A content drinking water (0.01 mg/l) (for 24 days) then lactation (for 14 days)75889gestation (for 21 days)controlled bisphenol A content drinking water (0.01 mg/l) (for 24 days)lactation (for 14 days)
8bisphenol A drink intake rateCrljJcl:SDfemale130.25ml/dgestation (for 21 days) then controlled bisphenol A content drinking water (0.01 mg/l) (for 31 days) then lactation (for 21 days)75890gestation (for 21 days)controlled bisphenol A content drinking water (0.01 mg/l) (for 31 days)lactation (for 21 days)
8bisphenol A drink intake rateCrljJcl:SDfemale44.96ml/dgestation (for 14 days) then controlled bisphenol A content drinking water (0.1 mg/l) (for 3 days)75891gestation (for 14 days)controlled bisphenol A content drinking water (0.1 mg/l) (for 3 days)
8bisphenol A drink intake rateCrljJcl:SDfemale60.47ml/dgestation (for 20 days) then controlled bisphenol A content drinking water (0.1 mg/l) (for 9 days)75892gestation (for 20 days)controlled bisphenol A content drinking water (0.1 mg/l) (for 9 days)
8bisphenol A drink intake rateCrljJcl:SDfemale80.28ml/dgestation (for 21 days) then controlled bisphenol A content drinking water (0.1 mg/l) (for 17 days) then lactation (for 7 days)75893gestation (for 21 days)controlled bisphenol A content drinking water (0.1 mg/l) (for 17 days)lactation (for 7 days)
8bisphenol A drink intake rateCrljJcl:SDfemale95.55ml/dgestation (for 21 days) then controlled bisphenol A content drinking water (0.1 mg/l) (for 24 days) then lactation (for 14 days)75894gestation (for 21 days)controlled bisphenol A content drinking water (0.1 mg/l) (for 24 days)lactation (for 14 days)
8bisphenol A drink intake rateCrljJcl:SDfemale135.87ml/dgestation (for 21 days) then controlled bisphenol A content drinking water (0.1 mg/l) (for 31 days) then lactation (for 21 days)75895gestation (for 21 days)controlled bisphenol A content drinking water (0.1 mg/l) (for 31 days)lactation (for 21 days)
8bisphenol A drink intake rateCrljJcl:SDfemale46.45ml/dgestation (for 14 days) then controlled bisphenol A content drinking water (1 mg/l) (for 3 days)75896gestation (for 14 days)controlled bisphenol A content drinking water (1 mg/l) (for 3 days)
8bisphenol A drink intake rateCrljJcl:SDfemale60.73ml/dgestation (for 20 days) then controlled bisphenol A content drinking water (1 mg/l) (for 9 days)75897gestation (for 20 days)controlled bisphenol A content drinking water (1 mg/l) (for 9 days)
8bisphenol A drink intake rateCrljJcl:SDfemale79.88ml/dgestation (for 21 days) then controlled bisphenol A content drinking water (1 mg/l) (for 17 days) then lactation (for 7 days)75898gestation (for 21 days)controlled bisphenol A content drinking water (1 mg/l) (for 17 days)lactation (for 7 days)
8bisphenol A drink intake rateCrljJcl:SDfemale104.63ml/dgestation (for 21 days) then controlled bisphenol A content drinking water (1 mg/l) (for 24 days) then lactation (for 14 days)75899gestation (for 21 days)controlled bisphenol A content drinking water (1 mg/l) (for 24 days)lactation (for 14 days)
8bisphenol A drink intake rateCrljJcl:SDfemale127.22ml/dgestation (for 21 days) then controlled bisphenol A content drinking water (1 mg/l) (for 31 days) then lactation (for 21 days)75900gestation (for 21 days)controlled bisphenol A content drinking water (1 mg/l) (for 31 days)lactation (for 21 days)
15sucrose drink intake volumeCrljJcl:SDmale81.29ml/dcontrolled in utero environment (for 10 days) then controlled bisphenol A content drinking water (0.1 mg/l) (for 31 days) then maternal milk (for 21 days) then controlled sucrose content drinking water (15 %) (for 119 days) and water (for 119 days)76006controlled in utero environment (for 10 days)controlled bisphenol A content drinking water (0.1 mg/l) (for 31 days)maternal milk (for 21 days)controlled sucrose content drinking water (15 %) (for 119 days)water (for 119 days)
15water drink intake rateCrljJcl:SDmale32.67ml/dcontrolled sucrose content drinking water (15 %) (for 21 days) and water (for 21 days)75986controlled sucrose content drinking water (15 %) (for 21 days)water (for 21 days)
15water drink intake rateCrljJcl:SDmale23.71ml/dcontrolled sucrose content drinking water (15 %) (for 49 days) and water (for 49 days)75987controlled sucrose content drinking water (15 %) (for 49 days)water (for 49 days)
15water drink intake rateCrljJcl:SDmale14.16ml/dcontrolled sucrose content drinking water (15 %) (for 119 days) and water (for 119 days)75988controlled sucrose content drinking water (15 %) (for 119 days)water (for 119 days)
15water drink intake rateCrljJcl:SDfemale22.15ml/dcontrolled sucrose content drinking water (15 %) (for 21 days) and water (for 21 days)75989controlled sucrose content drinking water (15 %) (for 21 days)water (for 21 days)
15water drink intake rateCrljJcl:SDfemale29.43ml/dcontrolled sucrose content drinking water (15 %) (for 49 days) and water (for 49 days)75990controlled sucrose content drinking water (15 %) (for 49 days)water (for 49 days)
15water drink intake rateCrljJcl:SDfemale19.55ml/dcontrolled sucrose content drinking water (15 %) (for 119 days) and water (for 119 days)75991controlled sucrose content drinking water (15 %) (for 119 days)water (for 119 days)
15water drink intake rateCrljJcl:SDmale30.45ml/dcontrolled in utero environment (for 10 days) then controlled bisphenol A content drinking water (0.1 mg/l) (for 31 days) then maternal milk (for 21 days) then controlled sucrose content drinking water (15 %) (for 21 days) and water (for 21 days)75992controlled in utero environment (for 10 days)controlled bisphenol A content drinking water (0.1 mg/l) (for 31 days)maternal milk (for 21 days)controlled sucrose content drinking water (15 %) (for 21 days)water (for 21 days)
15water drink intake rateCrljJcl:SDmale24.02ml/dcontrolled in utero environment (for 10 days) then controlled bisphenol A content drinking water (0.1 mg/l) (for 31 days) then maternal milk (for 21 days) then controlled sucrose content drinking water (15 %) (for 49 days) and water (for 49 days)75993controlled in utero environment (for 10 days)controlled bisphenol A content drinking water (0.1 mg/l) (for 31 days)maternal milk (for 21 days)controlled sucrose content drinking water (15 %) (for 49 days)water (for 49 days)
15water drink intake rateCrljJcl:SDmale5.86ml/dcontrolled in utero environment (for 10 days) then controlled bisphenol A content drinking water (0.1 mg/l) (for 31 days) then maternal milk (for 21 days) then controlled sucrose content drinking water (15 %) (for 119 days) and water (for 119 days)75994controlled in utero environment (for 10 days)controlled bisphenol A content drinking water (0.1 mg/l) (for 31 days)maternal milk (for 21 days)controlled sucrose content drinking water (15 %) (for 119 days)water (for 119 days)
15water drink intake rateCrljJcl:SDfemale29.68ml/dcontrolled in utero environment (for 10 days) then controlled bisphenol A content drinking water (0.1 mg/l) (for 31 days) then maternal milk (for 21 days) then controlled sucrose content drinking water (15 %) (for 21 days) and water (for 21 days)75995controlled in utero environment (for 10 days)controlled bisphenol A content drinking water (0.1 mg/l) (for 31 days)maternal milk (for 21 days)controlled sucrose content drinking water (15 %) (for 21 days)water (for 21 days)
15water drink intake rateCrljJcl:SDfemale22.3ml/dcontrolled in utero environment (for 10 days) then controlled bisphenol A content drinking water (0.1 mg/l) (for 31 days) then maternal milk (for 21 days) then controlled sucrose content drinking water (15 %) (for 49 days) and water (for 49 days)75996controlled in utero environment (for 10 days)controlled bisphenol A content drinking water (0.1 mg/l) (for 31 days)maternal milk (for 21 days)controlled sucrose content drinking water (15 %) (for 49 days)water (for 49 days)
15water drink intake rateCrljJcl:SDfemale22.6ml/dcontrolled in utero environment (for 10 days) then controlled bisphenol A content drinking water (0.1 mg/l) (for 31 days) then maternal milk (for 21 days) then controlled sucrose content drinking water (15 %) (for 119 days) and water (for 119 days)75997controlled in utero environment (for 10 days)controlled bisphenol A content drinking water (0.1 mg/l) (for 31 days)maternal milk (for 21 days)controlled sucrose content drinking water (15 %) (for 119 days)water (for 119 days)
15sucrose drink intake volumeCrljJcl:SDmale34.6ml/dcontrolled sucrose content drinking water (15 %) (for 21 days) and water (for 21 days)75998controlled sucrose content drinking water (15 %) (for 21 days)water (for 21 days)
15sucrose drink intake volumeCrljJcl:SDmale49.8ml/dcontrolled sucrose content drinking water (15 %) (for 49 days) and water (for 49 days)75999controlled sucrose content drinking water (15 %) (for 49 days)water (for 49 days)
15sucrose drink intake volumeCrljJcl:SDmale50.54ml/dcontrolled sucrose content drinking water (15 %) (for 119 days) and water (for 119 days)76000controlled sucrose content drinking water (15 %) (for 119 days)water (for 119 days)
15sucrose drink intake volumeCrljJcl:SDfemale27.48ml/dcontrolled sucrose content drinking water (15 %) (for 21 days) and water (for 21 days)76001controlled sucrose content drinking water (15 %) (for 21 days)water (for 21 days)
15sucrose drink intake volumeCrljJcl:SDfemale66.57ml/dcontrolled sucrose content drinking water (15 %) (for 49 days) and water (for 49 days)76002controlled sucrose content drinking water (15 %) (for 49 days)water (for 49 days)
15sucrose drink intake volumeCrljJcl:SDfemale62.92ml/dcontrolled sucrose content drinking water (15 %) (for 119 days) and water (for 119 days)76003controlled sucrose content drinking water (15 %) (for 119 days)water (for 119 days)
15sucrose drink intake volumeCrljJcl:SDmale42.57ml/dcontrolled in utero environment (for 10 days) then controlled bisphenol A content drinking water (0.1 mg/l) (for 31 days) then maternal milk (for 21 days) then controlled sucrose content drinking water (15 %) (for 21 days) and water (for 21 days)76004controlled in utero environment (for 10 days)controlled bisphenol A content drinking water (0.1 mg/l) (for 31 days)maternal milk (for 21 days)controlled sucrose content drinking water (15 %) (for 21 days)water (for 21 days)
15sucrose drink intake volumeCrljJcl:SDmale83.54ml/dcontrolled in utero environment (for 10 days) then controlled bisphenol A content drinking water (0.1 mg/l) (for 31 days) then maternal milk (for 21 days) then controlled sucrose content drinking water (15 %) (for 49 days) and water (for 49 days)76005controlled in utero environment (for 10 days)controlled bisphenol A content drinking water (0.1 mg/l) (for 31 days)maternal milk (for 21 days)controlled sucrose content drinking water (15 %) (for 49 days)water (for 49 days)
15sucrose drink intake volumeCrljJcl:SDfemale27.36ml/dcontrolled in utero environment (for 10 days) then controlled bisphenol A content drinking water (0.1 mg/l) (for 31 days) then maternal milk (for 21 days) then controlled sucrose content drinking water (15 %) (for 21 days) and water (for 21 days)76007controlled in utero environment (for 10 days)controlled bisphenol A content drinking water (0.1 mg/l) (for 31 days)maternal milk (for 21 days)controlled sucrose content drinking water (15 %) (for 21 days)water (for 21 days)
15sucrose drink intake volumeCrljJcl:SDfemale42.5ml/dcontrolled in utero environment (for 10 days) then controlled bisphenol A content drinking water (0.1 mg/l) (for 31 days) then maternal milk (for 21 days) then controlled sucrose content drinking water (15 %) (for 49 days) and water (for 49 days)76008controlled in utero environment (for 10 days)controlled bisphenol A content drinking water (0.1 mg/l) (for 31 days)maternal milk (for 21 days)controlled sucrose content drinking water (15 %) (for 49 days)water (for 49 days)
15sucrose drink intake volumeCrljJcl:SDfemale45ml/dcontrolled in utero environment (for 10 days) then controlled bisphenol A content drinking water (0.1 mg/l) (for 31 days) then maternal milk (for 21 days) then controlled sucrose content drinking water (15 %) (for 119 days) and water (for 119 days)76009controlled in utero environment (for 10 days)controlled bisphenol A content drinking water (0.1 mg/l) (for 31 days)maternal milk (for 21 days)controlled sucrose content drinking water (15 %) (for 119 days)water (for 119 days)
15sucrose intake volume to total fluid intake volume ratioCrljJcl:SDmale51.4%controlled sucrose content drinking water (15 %) (for 21 days) and water (for 21 days)76010controlled sucrose content drinking water (15 %) (for 21 days)water (for 21 days)
15sucrose intake volume to total fluid intake volume ratioCrljJcl:SDmale67.75%controlled sucrose content drinking water (15 %) (for 49 days) and water (for 49 days)76011controlled sucrose content drinking water (15 %) (for 49 days)water (for 49 days)
15sucrose intake volume to total fluid intake volume ratioCrljJcl:SDmale78.12%controlled sucrose content drinking water (15 %) (for 119 days) and water (for 119 days)76012controlled sucrose content drinking water (15 %) (for 119 days)water (for 119 days)
15sucrose intake volume to total fluid intake volume ratioCrljJcl:SDfemale55.38%controlled sucrose content drinking water (15 %) (for 21 days) and water (for 21 days)76013controlled sucrose content drinking water (15 %) (for 21 days)water (for 21 days)
15sucrose intake volume to total fluid intake volume ratioCrljJcl:SDfemale86.83%controlled sucrose content drinking water (15 %) (for 119 days) and water (for 119 days)76014controlled sucrose content drinking water (15 %) (for 119 days)water (for 119 days)
15sucrose intake volume to total fluid intake volume ratioCrljJcl:SDfemale69.34%controlled sucrose content drinking water (15 %) (for 49 days) and water (for 49 days)76015controlled sucrose content drinking water (15 %) (for 49 days)water (for 49 days)
15sucrose intake volume to total fluid intake volume ratioCrljJcl:SDmale51.68%controlled in utero environment (for 10 days) then controlled bisphenol A content drinking water (0.1 mg/l) (for 31 days) then maternal milk (for 21 days) then controlled sucrose content drinking water (15 %) (for 21 days) and water (for 21 days)76016controlled in utero environment (for 10 days)controlled bisphenol A content drinking water (0.1 mg/l) (for 31 days)maternal milk (for 21 days)controlled sucrose content drinking water (15 %) (for 21 days)water (for 21 days)
15sucrose intake volume to total fluid intake volume ratioCrljJcl:SDmale77.67%controlled in utero environment (for 10 days) then controlled bisphenol A content drinking water (0.1 mg/l) (for 31 days) then maternal milk (for 21 days) then controlled sucrose content drinking water (15 %) (for 49 days) and water (for 49 days)76017controlled in utero environment (for 10 days)controlled bisphenol A content drinking water (0.1 mg/l) (for 31 days)maternal milk (for 21 days)controlled sucrose content drinking water (15 %) (for 49 days)water (for 49 days)
15sucrose intake volume to total fluid intake volume ratioCrljJcl:SDmale93.29%controlled in utero environment (for 10 days) then controlled bisphenol A content drinking water (0.1 mg/l) (for 31 days) then maternal milk (for 21 days) then controlled sucrose content drinking water (15 %) (for 119 days) and water (for 119 days)76018controlled in utero environment (for 10 days)controlled bisphenol A content drinking water (0.1 mg/l) (for 31 days)maternal milk (for 21 days)controlled sucrose content drinking water (15 %) (for 119 days)water (for 119 days)
15sucrose intake volume to total fluid intake volume ratioCrljJcl:SDfemale47.97%controlled in utero environment (for 10 days) then controlled bisphenol A content drinking water (0.1 mg/l) (for 31 days) then maternal milk (for 21 days) then controlled sucrose content drinking water (15 %) (for 21 days) and water (for 21 days)76019controlled in utero environment (for 10 days)controlled bisphenol A content drinking water (0.1 mg/l) (for 31 days)maternal milk (for 21 days)controlled sucrose content drinking water (15 %) (for 21 days)water (for 21 days)
15sucrose intake volume to total fluid intake volume ratioCrljJcl:SDfemale65.59%controlled in utero environment (for 10 days) then controlled bisphenol A content drinking water (0.1 mg/l) (for 31 days) then maternal milk (for 21 days) then controlled sucrose content drinking water (15 %) (for 49 days) and water (for 49 days)76020controlled in utero environment (for 10 days)controlled bisphenol A content drinking water (0.1 mg/l) (for 31 days)maternal milk (for 21 days)controlled sucrose content drinking water (15 %) (for 49 days)water (for 49 days)
15sucrose intake volume to total fluid intake volume ratioCrljJcl:SDfemale66.47%controlled in utero environment (for 10 days) then controlled bisphenol A content drinking water (0.1 mg/l) (for 31 days) then maternal milk (for 21 days) then controlled sucrose content drinking water (15 %) (for 119 days) and water (for 119 days)76021controlled in utero environment (for 10 days)controlled bisphenol A content drinking water (0.1 mg/l) (for 31 days)maternal milk (for 21 days)controlled sucrose content drinking water (15 %) (for 119 days)water (for 119 days)
16saccharin intake volume to total fluid intake volume ratioCrljJcl:SDmale37.3%controlled saccharin content drinking water (0.25 %) (for 7 days) and water (for 7 days)76022controlled saccharin content drinking water (0.25 %) (for 7 days)water (for 7 days)
16saccharin intake volume to total fluid intake volume ratioCrljJcl:SDfemale62.7%controlled saccharin content drinking water (0.25 %) (for 7 days) and water (for 7 days)76023controlled saccharin content drinking water (0.25 %) (for 7 days)water (for 7 days)
16saccharin intake volume to total fluid intake volume ratioCrljJcl:SDmale24.2%controlled saccharin content drinking water (0.5 %) (for 7 days) and water (for 7 days)76024controlled saccharin content drinking water (0.5 %) (for 7 days)water (for 7 days)
16saccharin intake volume to total fluid intake volume ratioCrljJcl:SDfemale39.1%controlled saccharin content drinking water (0.5 %) (for 7 days) and water (for 7 days)76025controlled saccharin content drinking water (0.5 %) (for 7 days)water (for 7 days)
16saccharin intake volume to total fluid intake volume ratioCrljJcl:SDmale43.3%controlled in utero environment (for 10 days) then controlled bisphenol A content drinking water (0.01 mg/l) (for 31 days) then maternal milk (for 21 days) then controlled saccharin content drinking water (0.25 %) (for 7 days) and water (for 7 days)76026controlled in utero environment (for 10 days)controlled bisphenol A content drinking water (0.01 mg/l) (for 31 days)maternal milk (for 21 days)controlled saccharin content drinking water (0.25 %) (for 7 days)water (for 7 days)
16saccharin intake volume to total fluid intake volume ratioCrljJcl:SDfemale60.6%controlled in utero environment (for 10 days) then controlled bisphenol A content drinking water (0.01 mg/l) (for 31 days) then maternal milk (for 21 days) then controlled saccharin content drinking water (0.25 %) (for 7 days) and water (for 7 days)76027controlled in utero environment (for 10 days)controlled bisphenol A content drinking water (0.01 mg/l) (for 31 days)maternal milk (for 21 days)controlled saccharin content drinking water (0.25 %) (for 7 days)water (for 7 days)
16saccharin intake volume to total fluid intake volume ratioCrljJcl:SDmale26.5%controlled in utero environment (for 10 days) then controlled bisphenol A content drinking water (0.01 mg/l) (for 31 days) then maternal milk (for 21 days) then controlled saccharin content drinking water (0.5 %) (for 7 days) and water (for 7 days)76028controlled in utero environment (for 10 days)controlled bisphenol A content drinking water (0.01 mg/l) (for 31 days)maternal milk (for 21 days)controlled saccharin content drinking water (0.5 %) (for 7 days)water (for 7 days)
16saccharin intake volume to total fluid intake volume ratioCrljJcl:SDfemale39.6%controlled in utero environment (for 10 days) then controlled bisphenol A content drinking water (0.01 mg/l) (for 31 days) then maternal milk (for 21 days) then controlled saccharin content drinking water (0.5 %) (for 7 days) and water (for 7 days)76029controlled in utero environment (for 10 days)controlled bisphenol A content drinking water (0.01 mg/l) (for 31 days)maternal milk (for 21 days)controlled saccharin content drinking water (0.5 %) (for 7 days)water (for 7 days)
16saccharin intake volume to total fluid intake volume ratioCrljJcl:SDmale47%controlled in utero environment (for 10 days) then controlled bisphenol A content drinking water (0.1 mg/l) (for 31 days) then maternal milk (for 21 days) then controlled saccharin content drinking water (0.25 %) (for 7 days) and water (for 7 days)76030controlled in utero environment (for 10 days)controlled bisphenol A content drinking water (0.1 mg/l) (for 31 days)maternal milk (for 21 days)controlled saccharin content drinking water (0.25 %) (for 7 days)water (for 7 days)
16saccharin intake volume to total fluid intake volume ratioCrljJcl:SDfemale59.4%controlled in utero environment (for 10 days) then controlled bisphenol A content drinking water (0.1 mg/l) (for 31 days) then maternal milk (for 21 days) then controlled saccharin content drinking water (0.25 %) (for 7 days) and water (for 7 days)76031controlled in utero environment (for 10 days)controlled bisphenol A content drinking water (0.1 mg/l) (for 31 days)maternal milk (for 21 days)controlled saccharin content drinking water (0.25 %) (for 7 days)water (for 7 days)
16saccharin intake volume to total fluid intake volume ratioCrljJcl:SDmale23.7%controlled in utero environment (for 10 days) then controlled bisphenol A content drinking water (0.1 mg/l) (for 31 days) then maternal milk (for 21 days) then controlled saccharin content drinking water (0.5 %) (for 7 days) and water (for 7 days)76032controlled in utero environment (for 10 days)controlled bisphenol A content drinking water (0.1 mg/l) (for 31 days)maternal milk (for 21 days)controlled saccharin content drinking water (0.5 %) (for 7 days)water (for 7 days)
16saccharin intake volume to total fluid intake volume ratioCrljJcl:SDfemale39.4%controlled in utero environment (for 10 days) then controlled bisphenol A content drinking water (0.1 mg/l) (for 31 days) then maternal milk (for 21 days) then controlled saccharin content drinking water (0.5 %) (for 7 days) and water (for 7 days)76033controlled in utero environment (for 10 days)controlled bisphenol A content drinking water (0.1 mg/l) (for 31 days)maternal milk (for 21 days)controlled saccharin content drinking water (0.5 %) (for 7 days)water (for 7 days)
16saccharin intake volume to total fluid intake volume ratioCrljJcl:SDmale47.1%controlled in utero environment (for 10 days) then controlled bisphenol A content drinking water (1 mg/l) (for 31 days) then maternal milk (for 21 days) then controlled saccharin content drinking water (0.25 %) (for 7 days) and water (for 7 days)76034controlled in utero environment (for 10 days)controlled bisphenol A content drinking water (1 mg/l) (for 31 days)maternal milk (for 21 days)controlled saccharin content drinking water (0.25 %) (for 7 days)water (for 7 days)
16saccharin intake volume to total fluid intake volume ratioCrljJcl:SDfemale58.9%controlled in utero environment (for 10 days) then controlled bisphenol A content drinking water (1 mg/l) (for 31 days) then maternal milk (for 21 days) then controlled saccharin content drinking water (0.25 %) (for 7 days) and water (for 7 days)76035controlled in utero environment (for 10 days)controlled bisphenol A content drinking water (1 mg/l) (for 31 days)maternal milk (for 21 days)controlled saccharin content drinking water (0.25 %) (for 7 days)water (for 7 days)
16saccharin intake volume to total fluid intake volume ratioCrljJcl:SDmale26.7%controlled in utero environment (for 10 days) then controlled bisphenol A content drinking water (1 mg/l) (for 31 days) then maternal milk (for 21 days) then controlled saccharin content drinking water (0.5 %) (for 7 days) and water (for 7 days)76036controlled in utero environment (for 10 days)controlled bisphenol A content drinking water (1 mg/l) (for 31 days)maternal milk (for 21 days)controlled saccharin content drinking water (0.5 %) (for 7 days)water (for 7 days)
16saccharin intake volume to total fluid intake volume ratioCrljJcl:SDfemale37.2%controlled in utero environment (for 10 days) then controlled bisphenol A content drinking water (1 mg/l) (for 31 days) then maternal milk (for 21 days) then controlled saccharin content drinking water (0.5 %) (for 7 days) and water (for 7 days)76037controlled in utero environment (for 10 days)controlled bisphenol A content drinking water (1 mg/l) (for 31 days)maternal milk (for 21 days)controlled saccharin content drinking water (0.5 %) (for 7 days)water (for 7 days)
6food intake rateCrljJcl:SDfemale22.08g/dgestation (for 20 days)75763gestation (for 20 days)
6food intake rateCrljJcl:SDfemale43.84g/dgestation (for 21 days) then lactation (for 7 days)75764gestation (for 21 days)lactation (for 7 days)
6food intake rateCrljJcl:SDfemale52.68g/dgestation (for 21 days) then lactation (for 21 days)75766gestation (for 21 days)lactation (for 21 days)
6food intake rateCrljJcl:SDfemale56.55g/dgestation (for 21 days) then lactation (for 14 days)75765gestation (for 21 days)lactation (for 14 days)
8food intake rateCrljJcl:SDfemale24.46g/dgestation (for 14 days) then controlled bisphenol A content drinking water (1 mg/l) (for 3 days)75767gestation (for 14 days)controlled bisphenol A content drinking water (1 mg/l) (for 3 days)
8food intake rateCrljJcl:SDfemale24.35g/dgestation (for 14 days) then controlled bisphenol A content drinking water (0.01 mg/l) (for 3 days)75802gestation (for 14 days)controlled bisphenol A content drinking water (0.01 mg/l) (for 3 days)
8food intake rateCrljJcl:SDfemale22.61g/dgestation (for 20 days) then controlled bisphenol A content drinking water (0.01 mg/l) (for 9 days)75803gestation (for 20 days)controlled bisphenol A content drinking water (0.01 mg/l) (for 9 days)
8food intake rateCrljJcl:SDfemale42.77g/dgestation (for 21 days) then controlled bisphenol A content drinking water (0.1 mg/l) (for 17 days) then lactation (for 7 days)75804gestation (for 21 days)controlled bisphenol A content drinking water (0.1 mg/l) (for 17 days)lactation (for 7 days)
8food intake rateCrljJcl:SDfemale59.89g/dgestation (for 21 days) then controlled bisphenol A content drinking water (0.1 mg/l) (for 24 days) then lactation (for 14 days)75805gestation (for 21 days)controlled bisphenol A content drinking water (0.1 mg/l) (for 24 days)lactation (for 14 days)
8food intake rateCrljJcl:SDfemale54.66g/dgestation (for 21 days) then controlled bisphenol A content drinking water (0.1 mg/l) (for 31 days) then lactation (for 21 days)75806gestation (for 21 days)controlled bisphenol A content drinking water (0.1 mg/l) (for 31 days)lactation (for 21 days)
8food intake rateCrljJcl:SDfemale21.91g/dgestation (for 20 days) then controlled bisphenol A content drinking water (1 mg/l) (for 9 days)75807gestation (for 20 days)controlled bisphenol A content drinking water (1 mg/l) (for 9 days)
8food intake rateCrljJcl:SDfemale43.39g/dgestation (for 21 days) then controlled bisphenol A content drinking water (1 mg/l) (for 17 days) then lactation (for 7 days)75808gestation (for 21 days)controlled bisphenol A content drinking water (1 mg/l) (for 17 days)lactation (for 7 days)
8food intake rateCrljJcl:SDfemale26.94g/dgestation (for 14 days) then controlled bisphenol A content drinking water (0.1 mg/l) (for 3 days)75809gestation (for 14 days)controlled bisphenol A content drinking water (0.1 mg/l) (for 3 days)
8food intake rateCrljJcl:SDfemale54.38g/dgestation (for 21 days) then controlled bisphenol A content drinking water (1 mg/l) (for 24 days) then lactation (for 14 days)75810gestation (for 21 days)controlled bisphenol A content drinking water (1 mg/l) (for 24 days)lactation (for 14 days)
8food intake rateCrljJcl:SDfemale53.67g/dgestation (for 21 days) then controlled bisphenol A content drinking water (1 mg/l) (for 31 days) then lactation (for 21 days)75811gestation (for 21 days)controlled bisphenol A content drinking water (1 mg/l) (for 31 days)lactation (for 21 days)
15food intake rateCrljJcl:SDfemale8.96g/dcontrolled in utero environment (for 10 days) then controlled bisphenol A content drinking water (0.1 mg/l) (for 31 days) then maternal milk (for 21 days) then controlled sucrose content drinking water (15 %) (for 21 days) and water (for 21 days)75980controlled in utero environment (for 10 days)controlled bisphenol A content drinking water (0.1 mg/l) (for 31 days)maternal milk (for 21 days)controlled sucrose content drinking water (15 %) (for 21 days)water (for 21 days)
15food intake rateCrljJcl:SDmale27.97g/dcontrolled in utero environment (for 10 days) then controlled bisphenol A content drinking water (0.1 mg/l) (for 31 days) then maternal milk (for 21 days) then controlled sucrose content drinking water (15 %) (for 119 days) and water (for 119 days)75982controlled in utero environment (for 10 days)controlled bisphenol A content drinking water (0.1 mg/l) (for 31 days)maternal milk (for 21 days)controlled sucrose content drinking water (15 %) (for 119 days)water (for 119 days)
6food intake rateCrljJcl:SDfemale25.42g/dgestation (for 14 days)75762gestation (for 14 days)
8food intake rateCrljJcl:SDfemale23.8g/dgestation (for 20 days) then controlled bisphenol A content drinking water (0.1 mg/l) (for 9 days)75768gestation (for 20 days)controlled bisphenol A content drinking water (0.1 mg/l) (for 9 days)
8food intake rateCrljJcl:SDfemale44.7g/dgestation (for 21 days) then controlled bisphenol A content drinking water (0.01 mg/l) (for 17 days) then lactation (for 7 days)75769gestation (for 21 days)controlled bisphenol A content drinking water (0.01 mg/l) (for 17 days)lactation (for 7 days)
8food intake rateCrljJcl:SDfemale55.5g/dgestation (for 21 days) then controlled bisphenol A content drinking water (0.01 mg/l) (for 24 days) then lactation (for 14 days)75770gestation (for 21 days)controlled bisphenol A content drinking water (0.01 mg/l) (for 24 days)lactation (for 14 days)
8food intake rateCrljJcl:SDfemale50.69g/dgestation (for 21 days) then controlled bisphenol A content drinking water (0.01 mg/l) (for 31 days) then lactation (for 21 days)75801gestation (for 21 days)controlled bisphenol A content drinking water (0.01 mg/l) (for 31 days)lactation (for 21 days)
15food intake rateCrljJcl:SDmale22.77g/dcontrolled in utero environment (for 10 days) then controlled bisphenol A content drinking water (0.1 mg/l) (for 31 days) then maternal milk (for 21 days) then controlled sucrose content drinking water (15 %) (for 49 days) and water (for 49 days)75981controlled in utero environment (for 10 days)controlled bisphenol A content drinking water (0.1 mg/l) (for 31 days)maternal milk (for 21 days)controlled sucrose content drinking water (15 %) (for 49 days)water (for 49 days)
15food intake rateCrljJcl:SDmale14.14g/dcontrolled in utero environment (for 10 days) then controlled bisphenol A content drinking water (0.1 mg/l) (for 31 days) then maternal milk (for 21 days) then controlled sucrose content drinking water (15 %) (for 21 days) and water (for 21 days)75983controlled in utero environment (for 10 days)controlled bisphenol A content drinking water (0.1 mg/l) (for 31 days)maternal milk (for 21 days)controlled sucrose content drinking water (15 %) (for 21 days)water (for 21 days)
15food intake rateCrljJcl:SDfemale12.17g/dcontrolled in utero environment (for 10 days) then controlled bisphenol A content drinking water (0.1 mg/l) (for 31 days) then maternal milk (for 21 days) then controlled sucrose content drinking water (15 %) (for 49 days) and water (for 49 days)75984controlled in utero environment (for 10 days)controlled bisphenol A content drinking water (0.1 mg/l) (for 31 days)maternal milk (for 21 days)controlled sucrose content drinking water (15 %) (for 49 days)water (for 49 days)
15food intake rateCrljJcl:SDfemale12.53g/dcontrolled in utero environment (for 10 days) then controlled bisphenol A content drinking water (0.1 mg/l) (for 31 days) then maternal milk (for 21 days) then controlled sucrose content drinking water (15 %) (for 119 days) and water (for 119 days)75985controlled in utero environment (for 10 days)controlled bisphenol A content drinking water (0.1 mg/l) (for 31 days)maternal milk (for 21 days)controlled sucrose content drinking water (15 %) (for 119 days)water (for 119 days)
15food intake rateCrljJcl:SDmale14.48g/dcontrolled sucrose content drinking water (15 %) (for 21 days) and water (for 21 days)75933controlled sucrose content drinking water (15 %) (for 21 days)water (for 21 days)
15food intake rateCrljJcl:SDmale22.07g/dcontrolled sucrose content drinking water (15 %) (for 49 days) and water (for 49 days)75934controlled sucrose content drinking water (15 %) (for 49 days)water (for 49 days)
15food intake rateCrljJcl:SDmale28.12g/dcontrolled sucrose content drinking water (15 %) (for 119 days) and water (for 119 days)75935controlled sucrose content drinking water (15 %) (for 119 days)water (for 119 days)
15food intake rateCrljJcl:SDfemale12.32g/dcontrolled sucrose content drinking water (15 %) (for 21 days) and water (for 21 days)75936controlled sucrose content drinking water (15 %) (for 21 days)water (for 21 days)
15food intake rateCrljJcl:SDfemale13.05g/dcontrolled sucrose content drinking water (15 %) (for 49 days) and water (for 49 days)75937controlled sucrose content drinking water (15 %) (for 49 days)water (for 49 days)
15food intake rateCrljJcl:SDfemale14.04g/dcontrolled sucrose content drinking water (15 %) (for 119 days) and water (for 119 days)75938controlled sucrose content drinking water (15 %) (for 119 days)water (for 119 days)
6aorta wall extracellular elastin dry weight to aorta wall dry weight ratioBN/Rjmale31.4%control condition96778control condition
6aorta wall extracellular elastin dry weight to aorta wall dry weight ratioBN/Rjfemale31.8%control condition96779control condition
6aorta wall extracellular elastin dry weight to aorta wall dry weight ratioLOU/MBbbmale37.2%control condition96780control condition
6aorta wall extracellular elastin dry weight to aorta wall dry weight ratioLOU/MBbbfemale37.9%control condition96781control condition
6aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratioBN/Rjmale1.14control condition96782control condition
6aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratioBN/Rjfemale1.2control condition96783control condition
6aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratioLOU/MBbbmale1.58control condition96784control condition
6aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratioLOU/MBbbfemale1.58control condition96785control condition
5creatinine clearance to total kidney weight ratioSS-Renem1Mcwi+/+male0.9ml/min/gcontrolled sodium content diet (0.4 %) (for 42 days)98349controlled sodium content diet (0.4 %) (for 42 days)
9creatinine clearance to total kidney weight ratioSS-Renem1Mcwi+/-male0.83ml/min/gcontrolled sodium content diet (0.4 %) (for 42 days)98350controlled sodium content diet (0.4 %) (for 42 days)
8creatinine clearance to total kidney weight ratioSS-Renem1Mcwi-/-male0.33ml/min/gcontrolled sodium content diet (0.4 %) (for 42 days)98351controlled sodium content diet (0.4 %) (for 42 days)
8creatinine clearance to total kidney weight ratioSS-Renem1Mcwi+/+female0.87ml/min/gcontrolled sodium content diet (0.4 %) (for 42 days)98352controlled sodium content diet (0.4 %) (for 42 days)
9creatinine clearance to total kidney weight ratioSS-Renem1Mcwi+/-female0.79ml/min/gcontrolled sodium content diet (0.4 %) (for 42 days)98353controlled sodium content diet (0.4 %) (for 42 days)
4creatinine clearance to total kidney weight ratioSS-Renem1Mcwi-/-female0.3ml/min/gcontrolled sodium content diet (0.4 %) (for 42 days)98354controlled sodium content diet (0.4 %) (for 42 days)
8food intake rateSDmale19g/dunilateral nephrectomy (for 28 days)101611unilateral nephrectomy (for 28 days)
8food intake rateSDmale23g/dunilateral nephrectomy (for 28 days) then spironolactone (5.56 mg/kg/d) (for 28 days)101612unilateral nephrectomy (for 28 days)spironolactone (5.56 mg/kg/d) (for 28 days)
2mean arterial blood pressureF344male123.5556mmHgsucrose (10 %) (for 0.5 hours)105570sucrose (10 %) (for 0.5 hours)
3mean arterial blood pressureF344male120.9714mmHg4-methyl-2-(piperidin-1-yl) quinoline (1 mg/kg) (for 0.5 hours)1055714-methyl-2-(piperidin-1-yl) quinoline (1 mg/kg) (for 0.5 hours)
2mean arterial blood pressureF344male127.7mmHgsucrose (10 %) (for 1 hours)105572sucrose (10 %) (for 1 hours)
3mean arterial blood pressureF344male98.1553mmHg4-methyl-2-(piperidin-1-yl) quinoline (1 mg/kg) (for 1 hours)1055734-methyl-2-(piperidin-1-yl) quinoline (1 mg/kg) (for 1 hours)
25ratio of deaths related to chronic hypertension to total study population during a period of timeWKY/Nmale0%control condition107516control condition
25ratio of deaths related to chronic hypertension to total study population during a period of timeSHRSP/A3Nmale0%control condition107517control condition
25ratio of deaths related to chronic hypertension to total study population during a period of timeSHRSP/A3Nmale95%controlled sodium chloride content drinking water (1 %) (for 63 days) and controlled fat content diet (24.5 %) (for 63 days) and vehicle control condition (for 63 days)107518controlled sodium chloride content drinking water (1 %) (for 63 days)controlled fat content diet (24.5 %) (for 63 days)vehicle control condition (for 63 days)
25ratio of deaths related to chronic hypertension to total study population during a period of timeSHRSP/A3Nmale0%controlled sodium chloride content drinking water (1 %) (for 84 days) and controlled fat content diet (24.5 %) (for 84 days) and eprosartan (60 mg/kg/d) (for 84 days)107519controlled sodium chloride content drinking water (1 %) (for 84 days)controlled fat content diet (24.5 %) (for 84 days)eprosartan (60 mg/kg/d) (for 84 days)
12ratio of survivors of severe albuminuria to total study population during a period of timeSHRSP/A3NCrlmale50%controlled sodium chloride content drinking water (1 %) (for 91 days) and controlled fat content diet (24.5 %) (for 91 days) then vehicle control condition (for 35 days)109030controlled sodium chloride content drinking water (1 %) (for 91 days)controlled fat content diet (24.5 %) (for 91 days)vehicle control condition (for 35 days)
10ratio of survivors of severe albuminuria to total study population during a period of timeSHRSP/A3NCrlmale80%controlled sodium chloride content drinking water (1 %) (for 91 days) and controlled fat content diet (24.5 %) (for 91 days) then controlled SB-239063 content diet (1200 ppm) (for 35 days)109031controlled sodium chloride content drinking water (1 %) (for 91 days)controlled fat content diet (24.5 %) (for 91 days)controlled SB-239063 content diet (1200 ppm) (for 35 days)
5gestation period lengthISIAHfemale22dcontrol condition110679control condition
5gestation period lengthWAG/Novfemale22.3dcontrol condition110680control condition
10systolic blood pressureWAG/Novmale125mmHgcontrol condition107670control condition
10systolic blood pressureISIAHmale179mmHgcontrol condition107671control condition
10diastolic blood pressureWAG/Novmale82mmHgcontrol condition107672control condition
10diastolic blood pressureISIAHmale111mmHgcontrol condition107673control condition
20ratio of deaths related to left ventricular hypertrophy to total study population during a period of timeSHRSP/A3Nmale5%controlled sodium chloride content drinking water (1 %) (for 112 days) and controlled fat content diet (24.5 %) (for 112 days) and controlled enrasentan content diet (1200 ppm) (for 112 days)107935controlled sodium chloride content drinking water (1 %) (for 112 days)controlled fat content diet (24.5 %) (for 112 days)controlled enrasentan content diet (1200 ppm) (for 112 days)
20ratio of deaths related to left ventricular hypertrophy to total study population during a period of timeSHRSP/A3Nmale65%controlled sodium chloride content drinking water (1 %) (for 112 days) and controlled fat content diet (24.5 %) (for 112 days)107934controlled sodium chloride content drinking water (1 %) (for 112 days)controlled fat content diet (24.5 %) (for 112 days)
20ratio of deaths related to left ventricular hypertrophy to total study population during a period of timeSHRSP/A3Nmale10%controlled sodium chloride content drinking water (1 %) (for 112 days) and controlled fat content diet (24.5 %) (for 112 days) and controlled enrasentan content diet (2400 ppm) (for 112 days)107936controlled sodium chloride content drinking water (1 %) (for 112 days)controlled fat content diet (24.5 %) (for 112 days)controlled enrasentan content diet (2400 ppm) (for 112 days)
20ratio of deaths related to left ventricular hypertrophy to total study population during a period of timeSHRSP/A3Nmale0%control condition107933control condition
N/Akidney glomerulus countSHR-Chr 6MWF/Rkbmale33868control condition109027control condition
20ratio of deaths related to left ventricular hypertrophy to total study population during a period of timeSHRSP/A3Nmale0%controlled sodium chloride content drinking water (1 %) (for 126 days) and controlled fat content diet (24.5 %) (for 126 days) and controlled carvedilol content diet (2400 ppm) (for 126 days)107112controlled sodium chloride content drinking water (1 %) (for 126 days)controlled fat content diet (24.5 %) (for 126 days)controlled carvedilol content diet (2400 ppm) (for 126 days)
20ratio of deaths related to left ventricular hypertrophy to total study population during a period of timeSHRSP/A3Nmale55%controlled sodium chloride content drinking water (1 %) (for 126 days) and controlled fat content diet (24.5 %) (for 126 days)107113controlled sodium chloride content drinking water (1 %) (for 126 days)controlled fat content diet (24.5 %) (for 126 days)
20ratio of deaths related to left ventricular hypertrophy to total study population during a period of timeSHRSP/A3Nmale0%standard condition (for 126 days)107114standard condition (for 126 days)
20ratio of deaths related to left ventricular hypertrophy to total study population during a period of timeWKY/NCrlmale0%standard condition (for 126 days)107115standard condition (for 126 days)