| BN/NHsdMcwi |
plasma renin activity level |
controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) |
PhysGen Renal B data |
renin activity |
female |
80.0 days-99.0 days |
7 |
1.61 |
ng/ml/h |
0.88 |
2.33 |
radioimmunoassay |
|
|
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52919 |
482 |
| BN/NHsdMcwi |
plasma creatinine level |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
blood creatinine amount |
female |
80.0 days-99.0 days |
15 |
0.35 |
mg/dl |
0.02 |
0.08 |
radioimmunoassay |
|
|
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52236 |
482 |
| BN/NHsdMcwi |
plasma renin activity level |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
renin activity |
male |
80.0 days-99.0 days |
8 |
1.01 |
ng/ml/h |
0.15 |
0.43 |
radioimmunoassay |
|
|
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52480 |
482 |
| BN/NHsdMcwi |
plasma creatinine level |
controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) |
PhysGen Renal A data |
blood creatinine amount |
male |
87.0 days-120.0 days |
3 |
0.29 |
mg/dl |
0.0 |
0.01 |
radioimmunoassay |
|
|
|
|
|
Moms and pups used in studies were fed Teklad |
51321 |
481 |
| BN/NHsdMcwi |
plasma creatinine level |
controlled sodium content diet (4 %) (between 17 and 36 days) |
PhysGen Renal A data |
blood creatinine amount |
male |
87.0 days-120.0 days |
3 |
0.28 |
mg/dl |
0.03 |
0.05 |
radioimmunoassay |
|
|
|
|
|
Moms and pups used in studies were fed Teklad |
51655 |
481 |
| BN/NHsdMcwi |
serum triiodothyronine level |
controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) |
Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. |
blood triiodothyronine amount |
male |
91.0 days
| 8 |
70.24 |
µg/dL |
4.85 |
13.71 |
radioimmunoassay |
|
|
RIA; RRID:AB_2940789 |
Serum total T3 |
Changed sex from M to male to standardize across records, 7-30-2024 |
|
139039 |
3292 |
| BN/NHsdMcwi |
plasma renin activity level |
controlled sodium content diet (4 %) (between 17 and 36 days) |
PhysGen Renal A data |
renin activity |
male |
87.0 days-120.0 days |
3 |
2.06 |
ng/ml/h |
0.69 |
1.19 |
radioimmunoassay |
|
|
|
|
|
Moms and pups used in studies were fed Teklad |
51844 |
481 |
| BN/NHsdMcwi |
plasma creatinine level |
controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) |
PhysGen Renal B data |
blood creatinine amount |
male |
80.0 days-99.0 days |
8 |
0.24 |
mg/dl |
0.03 |
0.07 |
radioimmunoassay |
|
|
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52283 |
482 |
| BN/NHsdMcwi |
urine albumin excretion rate |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
urine albumin amount |
male |
80.0 days-99.0 days |
10 |
4.05 |
mg/d |
1.24 |
3.93 |
radioimmunoassay |
|
|
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52625 |
482 |
| BN/NHsdMcwi |
plasma creatinine level |
controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) |
PhysGen Renal A data |
blood creatinine amount |
female |
87.0 days-120.0 days |
2 |
0.26 |
mg/dl |
0.06 |
0.08 |
radioimmunoassay |
|
|
|
|
|
Moms and pups used in studies were fed Dyets |
51179 |
481 |
| BN/NHsdMcwi |
serum thyroxine level |
controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) |
Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. |
blood thyroxine amount |
male |
91.0 days
| 8 |
4.19 |
ng/dL |
0.21 |
0.6 |
radioimmunoassay |
|
|
RIA; RRID:AB_2940788 |
Serum total T4 |
Changed sex from M to male to standardize across records, 7-30-2024 |
|
139040 |
3292 |
| BN/NHsdMcwi |
plasma creatinine level |
controlled sodium content diet (4 %) (between 17 and 36 days) |
PhysGen Renal A data |
blood creatinine amount |
female |
87.0 days-120.0 days |
2 |
0.27 |
mg/dl |
0.04 |
0.06 |
radioimmunoassay |
|
|
|
|
|
Moms and pups used in studies were fed Dyets |
52043 |
481 |
| BN/NHsdMcwi |
plasma renin activity level |
controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) |
PhysGen Renal B data |
renin activity |
male |
80.0 days-99.0 days |
8 |
0.26 |
ng/ml/h |
0.03 |
0.08 |
radioimmunoassay |
|
|
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52918 |
482 |
| BN/NHsdMcwi |
plasma creatinine level |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
blood creatinine amount |
male |
80.0 days-99.0 days |
8 |
0.41 |
mg/dl |
0.02 |
0.06 |
radioimmunoassay |
|
|
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52235 |
482 |
| BN/NHsdMcwi |
plasma renin activity level |
controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) |
PhysGen Renal A data |
renin activity |
female |
87.0 days-120.0 days |
3 |
7.64 |
ng/ml/h |
1.68 |
2.91 |
radioimmunoassay |
|
|
|
|
|
Moms and pups used in studies were fed Teklad |
51015 |
481 |
| BN/NHsdMcwi |
plasma renin activity level |
controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) |
PhysGen Renal A data |
renin activity |
male |
87.0 days-120.0 days |
1 |
8.99 |
ng/ml/h |
|
|
radioimmunoassay |
|
|
|
|
|
Moms and pups used in studies were fed Teklad |
51014 |
481 |
| BN/NHsdMcwi |
plasma creatinine level |
controlled sodium content diet (4 %) (between 17 and 36 days) |
PhysGen Renal A data |
blood creatinine amount |
female |
87.0 days-120.0 days |
6 |
0.28 |
mg/dl |
0.0 |
0.01 |
radioimmunoassay |
|
|
|
|
|
Moms and pups used in studies were fed Teklad |
51656 |
481 |
| BN/NHsdMcwi |
serum triiodothyronine level |
controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) |
Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. |
blood triiodothyronine amount |
female |
91.0 days
| 7 |
77.7 |
µg/dL |
3.4 |
9.0 |
radioimmunoassay |
|
|
RIA; RRID:AB_2940789 |
Serum total T3 |
Changed sex from F to female to standardize across records, 7-30-2024 |
|
138923 |
3292 |
| BN/NHsdMcwi |
plasma insulin level |
controlled sodium chloride content drinking water (1 %) (for 7 days) then controlled sodium chloride content drinking water (2 %) (for 7 days) then controlled sodium chloride content drinking water (1 %) (for 9 days) then water (for 12 days) |
Gilibert S, et al., J Hypertens. 2009 Jun;27(6):1186-93. |
blood insulin amount |
male |
175.0 days
| 10 |
20.37 |
mU/l |
0.91 |
2.88 |
radioimmunoassay |
0.0 |
|
|
|
|
|
102092 |
2645 |
| BN/NHsdMcwi |
plasma renin activity level |
controlled sodium content diet (4 %) (between 17 and 36 days) |
PhysGen Renal A data |
renin activity |
female |
87.0 days-120.0 days |
5 |
1.48 |
ng/ml/h |
0.33 |
0.74 |
radioimmunoassay |
|
|
|
|
|
Moms and pups used in studies were fed Teklad |
51845 |
481 |
| BN/NHsdMcwi |
plasma creatinine level |
controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) |
PhysGen Renal A data |
blood creatinine amount |
female |
87.0 days-120.0 days |
3 |
0.3 |
mg/dl |
0.02 |
0.04 |
radioimmunoassay |
|
|
|
|
|
Moms and pups used in studies were fed Teklad |
51322 |
481 |
| BN/NHsdMcwi |
serum thyroxine level |
controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) |
Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. |
blood thyroxine amount |
female |
91.0 days
| 7 |
3.47 |
ng/dL |
0.19 |
0.51 |
radioimmunoassay |
|
|
RIA; RRID:AB_2940788 |
Serum total T4 |
Changed sex from F to female to standardize across records, 7-30-2024 |
|
138924 |
3292 |
| BN/NHsdMcwi |
plasma creatinine level |
controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) |
PhysGen Renal B data |
blood creatinine amount |
female |
80.0 days-99.0 days |
7 |
0.33 |
mg/dl |
0.03 |
0.08 |
radioimmunoassay |
|
|
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52284 |
482 |
| BN/NHsdMcwi |
urine albumin excretion rate |
controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) |
PhysGen Renal B data |
urine albumin amount |
male |
80.0 days-99.0 days |
8 |
5.41 |
mg/d |
1.01 |
2.85 |
radioimmunoassay |
|
|
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52426 |
482 |
| BN/NHsdMcwi |
urine albumin excretion rate |
controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) |
PhysGen Renal B data |
urine albumin amount |
female |
80.0 days-99.0 days |
11 |
7.16 |
mg/d |
2.64 |
8.76 |
radioimmunoassay |
|
|
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52427 |
482 |
| BN/NHsdMcwi |
plasma renin activity level |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
renin activity |
female |
80.0 days-99.0 days |
15 |
4.4 |
ng/ml/h |
1.26 |
4.87 |
radioimmunoassay |
|
|
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52481 |
482 |
| BN/NHsdMcwi |
urine albumin excretion rate |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
urine albumin amount |
female |
80.0 days-99.0 days |
21 |
2.16 |
mg/d |
0.38 |
1.73 |
radioimmunoassay |
|
|
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52626 |
482 |
| BN/NHsdMcwi |
plasma insulin level to plasma glucose level ratio |
controlled sodium chloride content drinking water (1 %) (for 7 days) then controlled sodium chloride content drinking water (2 %) (for 7 days) then controlled sodium chloride content drinking water (1 %) (for 9 days) then water (for 12 days) |
Gilibert S, et al., J Hypertens. 2009 Jun;27(6):1186-93. |
blood insulin amount |
male |
175.0 days
| 10 |
2.76 |
mU/mmol |
0.13 |
0.41 |
radioimmunoassay |
0.0 |
|
mU/mmol |
plasma insulin level to plasma glucose level ratio (CMO:0003555) |
|
|
102096 |
2645 |