| SS/JrHsdMcwi |
urine sodium excretion rate |
controlled sodium content diet (4 %) (between 17 and 36 days) |
PhysGen Renal A data |
urine sodium amount |
male |
87.0 days-120.0 days |
19 |
11.47 |
mEq/d |
0.98 |
4.28 |
flame atomic emission spectrometry |
|
|
|
|
Moms and pups used in studies were fed Teklad |
51882 |
481 |
| SS/JrHsdMcwi |
urine sodium excretion rate |
controlled sodium content diet (4 %) (between 17 and 36 days) |
PhysGen Renal A data |
urine sodium amount |
male |
87.0 days-120.0 days |
20 |
9.28 |
mEq/d |
1.19 |
5.33 |
flame atomic emission spectrometry |
|
|
|
|
Moms and pups used in studies were fed Dyets |
52012 |
481 |
| SS/JrHsdMcwi |
urine sodium excretion rate |
controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) |
PhysGen Renal A data |
urine sodium amount |
male |
87.0 days-120.0 days |
20 |
1.46 |
mEq/d |
0.2 |
0.9 |
flame atomic emission spectrometry |
|
|
|
|
Moms and pups used in studies were fed Dyets |
51266 |
481 |
| SS/JrHsdMcwi |
urine sodium excretion rate |
controlled sodium content diet (4 %) (between 17 and 36 days) |
PhysGen Renal A data |
urine sodium amount |
male |
87.0 days-120.0 days |
5 |
9.79 |
mEq/d |
1.85 |
4.14 |
flame atomic emission spectrometry |
|
|
|
|
Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks |
51294 |
481 |
| SS/JrHsdMcwi |
urine sodium excretion rate |
controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) |
PhysGen Renal A data |
urine sodium amount |
male |
87.0 days-120.0 days |
20 |
1.21 |
mEq/d |
0.14 |
0.65 |
flame atomic emission spectrometry |
|
|
|
|
Moms and pups used in studies were fed Teklad |
51516 |
481 |
| SS/JrHsdMcwi |
serum potassium level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood potassium amount |
female |
77.0 days-91.0 days |
6 |
4.78 |
mmol/l |
0.31 |
0.75 |
flame atomic emission spectrometry |
|
|
|
|
Moms and pups used in studies were fed Dyets |
38833 |
401 |
| SS/JrHsdMcwi |
urine sodium excretion rate |
controlled sodium content diet (4 %) (between 17 and 36 days) |
PhysGen Renal A data |
urine sodium amount |
female |
87.0 days-120.0 days |
11 |
7.72 |
mEq/d |
1.23 |
4.07 |
flame atomic emission spectrometry |
|
|
|
|
Moms and pups used in studies were fed Dyets |
52017 |
481 |
| SS/JrHsdMcwi |
urine potassium excretion rate |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
urine potassium amount |
male |
80.0 days-99.0 days |
64 |
1.29 |
mEq/d |
0.06 |
0.5 |
flame atomic emission spectrometry |
|
|
urine potassium analysis |
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52957 |
482 |
| SS/JrHsdMcwi |
urine sodium excretion rate to body weight ratio |
controlled in situ renal perfusion pressure (125-130 mmHg) (for 0.3 hours) |
Roman RJ, et al., Am J Physiol Renal Physiol. 2006 Jun;290(6):F1463-71. Epub 2006 Jan 5. |
urine sodium amount |
male |
70.0 days
| 10 |
0.52 |
uEq/min/g |
0.12 |
0.38 |
flame atomic emission spectrometry |
1200.0 |
|
|
urine sodium excretion rate to kidney weight ratio |
|
64967 |
272 |
| SS/JrHsdMcwi |
serum potassium level |
controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) |
PhysGen Biochemistry data |
blood potassium amount |
female |
70.0 days-84.0 days |
17 |
3.85 |
mmol/l |
0.07 |
0.31 |
flame atomic emission spectrometry |
|
|
|
|
|
61759 |
527 |
| SS/JrHsdMcwi |
urine fractional sodium excretion |
controlled in situ renal perfusion pressure (125-130 mmHg) (for 0.3 hours) then controlled in situ renal perfusion pressure (150 mmHg) (for 0.3 hours) then controlled in situ renal perfusion pressure (170-175 mmHg) (for 0.3 hours) |
Roman RJ, et al., Am J Physiol Renal Physiol. 2006 Jun;290(6):F1463-71. Epub 2006 Jan 5. |
urine sodium amount |
male |
70.0 days
| 10 |
3.91 |
% |
0.85 |
2.69 |
flame atomic emission spectrometry |
1200.0 |
|
|
Fractional sodium excretion |
|
64935 |
272 |
| SS/JrHsdMcwi |
urine sodium excretion rate |
controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) |
PhysGen Renal A data |
urine sodium amount |
male |
87.0 days-120.0 days |
6 |
1.39 |
mEq/d |
0.12 |
0.29 |
flame atomic emission spectrometry |
|
|
|
|
Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks |
51045 |
481 |
| SS/JrHsdMcwi |
serum sodium level |
controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) |
PhysGen Biochemistry data |
blood sodium amount |
male |
70.0 days-84.0 days |
40 |
143.98 |
mmol/l |
0.37 |
2.33 |
flame atomic emission spectrometry |
|
|
|
|
|
60901 |
527 |
| SS/JrHsdMcwi |
serum sodium level |
controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) |
PhysGen Biochemistry data |
blood sodium amount |
female |
70.0 days-84.0 days |
17 |
143.24 |
mmol/l |
0.86 |
3.53 |
flame atomic emission spectrometry |
|
|
|
|
|
60907 |
527 |
| SS/JrHsdMcwi |
urine sodium excretion rate |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
urine sodium amount |
female |
80.0 days-99.0 days |
11 |
18.24 |
mEq/d |
1.67 |
5.53 |
flame atomic emission spectrometry |
|
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52767 |
482 |
| SS/JrHsdMcwi |
serum potassium level |
controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) |
PhysGen Biochemistry data |
blood potassium amount |
male |
70.0 days-84.0 days |
40 |
4.12 |
mmol/l |
0.12 |
0.77 |
flame atomic emission spectrometry |
|
|
|
|
|
61753 |
527 |
| SS/JrHsdMcwi |
urine fractional sodium excretion |
controlled in situ renal perfusion pressure (125-130 mmHg) (for 0.3 hours) |
Roman RJ, et al., Am J Physiol Renal Physiol. 2006 Jun;290(6):F1463-71. Epub 2006 Jan 5. |
urine sodium amount |
male |
70.0 days
| 10 |
1.3 |
% |
0.37 |
1.17 |
flame atomic emission spectrometry |
1200.0 |
|
|
Fractional |
|
64937 |
272 |
| SS/JrHsdMcwi |
urine potassium excretion rate |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
urine potassium amount |
female |
80.0 days-99.0 days |
11 |
1.15 |
mEq/d |
0.05 |
0.18 |
flame atomic emission spectrometry |
|
|
urine potassium analysis |
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52963 |
482 |
| SS/JrHsdMcwi |
urine sodium excretion rate |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
urine sodium amount |
male |
80.0 days-99.0 days |
64 |
14.23 |
mEq/d |
0.97 |
7.78 |
flame atomic emission spectrometry |
|
|
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52761 |
482 |
| SS/JrHsdMcwi |
urine sodium excretion rate |
controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) |
PhysGen Renal A data |
urine sodium amount |
female |
87.0 days-120.0 days |
11 |
0.78 |
mEq/d |
0.1 |
0.33 |
flame atomic emission spectrometry |
|
|
|
|
Moms and pups used in studies were fed Dyets |
51271 |
481 |
| SS/JrHsdMcwi |
urine sodium excretion rate to body weight ratio |
controlled in situ renal perfusion pressure (125-130 mmHg) (for 0.3 hours) then controlled in situ renal perfusion pressure (150 mmHg) (for 0.3 hours) then controlled in situ renal perfusion pressure (170-175 mmHg) (for 0.3 hours) |
Roman RJ, et al., Am J Physiol Renal Physiol. 2006 Jun;290(6):F1463-71. Epub 2006 Jan 5. |
urine sodium amount |
male |
70.0 days
| 10 |
2.58 |
uEq/min/g |
0.68 |
2.15 |
flame atomic emission spectrometry |
1200.0 |
|
|
urine sodium excretion rate to kidney weight ratio |
|
64968 |
272 |
| SS/JrHsdMcwi |
serum potassium level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood potassium amount |
male |
77.0 days-91.0 days |
4 |
4.68 |
mmol/l |
0.34 |
0.69 |
flame atomic emission spectrometry |
|
|
|
|
Moms and pups used in studies were fed Dyets |
38828 |
401 |