Hsd:SD |
scotopic B wave amplitude of ERG waveform |
controlled exposure to darkness (for 12 hours) then visible light stimulus (5 cd/m2) |
Conlon TJ, et al., Hum Gene Ther Clin Dev. 2013 Mar;24(1):23-8. doi: 10.1089/humc.2013.037. Epub 2013 Apr 3. |
rod electrophysiology trait |
both |
0 days
| 4 |
456.0 |
uV |
|
|
electroretinography |
cornea |
0.0 |
|
0 |
|
|
scotopic b-wave ERG |
108641 |
3128 |
Hsd:SD |
scotopic B wave amplitude of ERG waveform |
vehicle control condition (2 ul) then controlled exposure to darkness (for 12 hours) then visible light stimulus (5 cd/m2) |
Conlon TJ, et al., Hum Gene Ther Clin Dev. 2013 Mar;24(1):23-8. doi: 10.1089/humc.2013.037. Epub 2013 Apr 3. |
rod electrophysiology trait |
both |
0 days
| 4 |
338.0 |
uV |
|
|
electroretinography |
cornea |
0.0 |
subretinal injection |
30 |
days |
|
scotopic b-wave ERG |
108640 |
3128 |
RCS-p+/LavRrrc |
scotopic B wave amplitude of ERG waveform |
gene transfer using empty plasmid vector pVAX2 (30 ug) then controlled exposure to darkness (for 1 days) then visible light stimulus (3 cd x s/m2) |
Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. |
rod electrophysiology trait |
both |
75 days
| 5 |
114.0 |
uV |
16.1 |
36.0 |
electroretinography |
cornea |
0.0 |
plasmid delivery |
59 |
days |
|
scotopic b-wave ERG |
108703 |
3131 |
RCS-rdy+ p+/LavRrrc |
scotopic B wave amplitude of ERG waveform |
DL-α-aminoadipate (70 ug/ul) then controlled exposure to darkness (for 12 hours) then visible light stimulus (0.5 log(cd x m/s2)) |
Dai J, et al., Sci Rep. 2017 Jun 14;7(1):3546. doi: 10.1038/s41598-017-03702-z. |
rod electrophysiology trait |
both |
0 days
| 6 |
411.83 |
uV |
43.52 |
106.6 |
electroretinography |
cornea |
0.0 |
subretinal injection |
7 |
days |
dl-aaa |
b-wave amplitude ERG |
108408 |
3123 |
RCS-rdy+ p+/LavRrrc |
scotopic B wave amplitude of ERG waveform |
phosphate buffered saline (4 ul) then controlled exposure to darkness (for 12 hours) then visible light stimulus (-4.5 log(cd x m/s2)) |
Dai J, et al., Sci Rep. 2017 Jun 14;7(1):3546. doi: 10.1038/s41598-017-03702-z. |
rod electrophysiology trait |
both |
0 days
| 6 |
62.22 |
uV |
18.42 |
45.12 |
electroretinography |
cornea |
0.0 |
subretinal injection |
7 |
days |
dl-aaa |
b-wave amplitude ERG |
108410 |
3123 |
RCS-rdy+ p+/LavRrrc |
scotopic B wave amplitude of ERG waveform |
phosphate buffered saline (4 ul) then controlled exposure to darkness (for 12 hours) then visible light stimulus (1 log(cd x m/s2)) |
Dai J, et al., Sci Rep. 2017 Jun 14;7(1):3546. doi: 10.1038/s41598-017-03702-z. |
rod electrophysiology trait |
both |
0 days
| 6 |
652.5 |
uV |
65.65 |
160.81 |
electroretinography |
cornea |
0.0 |
subretinal injection |
7 |
days |
dl-aaa |
b-wave amplitude ERG |
108415 |
3123 |
RCS-rdy+ p+/LavRrrc |
scotopic B wave amplitude of ERG waveform |
DL-α-aminoadipate (70 ug/ul) then controlled exposure to darkness (for 12 hours) then visible light stimulus (-2.5 log(cd x m/s2)) |
Dai J, et al., Sci Rep. 2017 Jun 14;7(1):3546. doi: 10.1038/s41598-017-03702-z. |
rod electrophysiology trait |
both |
0 days
| 6 |
373.83 |
uV |
17.47 |
42.79 |
electroretinography |
cornea |
0.0 |
subretinal injection |
10 |
days |
dl-aaa |
b-wave amplitude ERG |
108429 |
3123 |
RCS-rdy+ p+/LavRrrc |
scotopic B wave amplitude of ERG waveform |
DL-α-aminoadipate (70 ug/ul) then controlled exposure to darkness (for 12 hours) then visible light stimulus (-0.02 log(cd x m/s2)) |
Dai J, et al., Sci Rep. 2017 Jun 14;7(1):3546. doi: 10.1038/s41598-017-03702-z. |
rod electrophysiology trait |
both |
0 days
| 6 |
437.0 |
uV |
33.32 |
81.62 |
electroretinography |
cornea |
0.0 |
subretinal injection |
10 |
days |
dl-aaa |
b-wave amplitude ERG |
108431 |
3123 |
RCS-rdy+ p+/LavRrrc |
scotopic B wave amplitude of ERG waveform |
DL-α-aminoadipate (70 ug/ul) then controlled exposure to darkness (for 12 hours) then visible light stimulus (1 log(cd x m/s2)) |
Dai J, et al., Sci Rep. 2017 Jun 14;7(1):3546. doi: 10.1038/s41598-017-03702-z. |
rod electrophysiology trait |
both |
0 days
| 6 |
594.5 |
uV |
24.04 |
58.89 |
electroretinography |
cornea |
0.0 |
subretinal injection |
10 |
days |
dl-aaa |
b-wave amplitude ERG |
108433 |
3123 |
RCS-rdy+ p+/LavRrrc |
scotopic B wave amplitude of ERG waveform |
phosphate buffered saline (4 ul) then controlled exposure to darkness (for 12 hours) then visible light stimulus (1 log(cd x m/s2)) |
Dai J, et al., Sci Rep. 2017 Jun 14;7(1):3546. doi: 10.1038/s41598-017-03702-z. |
rod electrophysiology trait |
both |
0 days
| 6 |
598.67 |
uV |
39.64 |
97.1 |
electroretinography |
cornea |
0.0 |
subretinal injection |
30 |
min |
pbs |
b-wave amplitude ERG |
108463 |
3123 |
RCS-rdy+ p+/LavRrrc |
scotopic B wave amplitude of ERG waveform |
2-Chloro-5-hydroxyphenylglycine (200 umol) then controlled exposure to darkness (for 12 hours) then visible light stimulus (-2.5 log(cd x m/s2)) |
Dai J, et al., Sci Rep. 2017 Jun 14;7(1):3546. doi: 10.1038/s41598-017-03702-z. |
rod electrophysiology trait |
both |
0 days
| 11 |
270.09 |
uV |
34.35 |
113.93 |
electroretinography |
cornea |
0.0 |
subretinal injection |
2 |
days |
CHPG |
b-wave amplitude ERG |
108477 |
3123 |
RCS-rdy+ p+/LavRrrc |
scotopic B wave amplitude of ERG waveform |
phosphate buffered saline (4 ul) then controlled exposure to darkness (for 12 hours) then visible light stimulus (-0.5 log(cd x m/s2)) |
Dai J, et al., Sci Rep. 2017 Jun 14;7(1):3546. doi: 10.1038/s41598-017-03702-z. |
rod electrophysiology trait |
both |
0 days
| 11 |
466.45 |
uV |
51.69 |
171.44 |
electroretinography |
cornea |
0.0 |
subretinal injection |
2 |
days |
pbs |
b wave amplitude ERG |
108484 |
3123 |
RCS-rdy+ p+/LavRrrc |
scotopic B wave amplitude of ERG waveform |
phosphate buffered saline (4 ul) then controlled exposure to darkness (for 12 hours) then visible light stimulus (-0.02 log(cd x m/s2)) |
Dai J, et al., Sci Rep. 2017 Jun 14;7(1):3546. doi: 10.1038/s41598-017-03702-z. |
rod electrophysiology trait |
both |
0 days
| 11 |
518.55 |
uV |
54.69 |
181.39 |
electroretinography |
cornea |
0.0 |
subretinal injection |
2 |
days |
pbs |
b wave amplitude ERG |
108485 |
3123 |
RCS-rdy+ p+/LavRrrc |
scotopic B wave amplitude of ERG waveform |
2-Chloro-5-hydroxyphenylglycine (200 umol) then controlled exposure to darkness (for 12 hours) then visible light stimulus (-2.5 log(cd x m/s2)) |
Dai J, et al., Sci Rep. 2017 Jun 14;7(1):3546. doi: 10.1038/s41598-017-03702-z. |
rod electrophysiology trait |
both |
0 days
| 6 |
385.17 |
uV |
61.99 |
151.84 |
electroretinography |
cornea |
0.0 |
subretinal injection |
10 |
days |
CHPG |
b-wave amplitude ERG |
108501 |
3123 |
RCS-rdy+ p+/LavRrrc |
scotopic B wave amplitude of ERG waveform |
2-Chloro-5-hydroxyphenylglycine (200 umol) then controlled exposure to darkness (for 12 hours) then visible light stimulus (-0.5 log(cd x m/s2)) |
Dai J, et al., Sci Rep. 2017 Jun 14;7(1):3546. doi: 10.1038/s41598-017-03702-z. |
rod electrophysiology trait |
both |
0 days
| 6 |
429.5 |
uV |
66.11 |
161.94 |
electroretinography |
cornea |
0.0 |
subretinal injection |
10 |
days |
CHPG |
b-wave amplitude ERG |
108502 |
3123 |
RCS-rdy+ p+/LavRrrc |
scotopic B wave amplitude of ERG waveform |
phosphate buffered saline (4 ul) then controlled exposure to darkness (for 12 hours) then visible light stimulus (-4.5 log(cd x m/s2)) |
Dai J, et al., Sci Rep. 2017 Jun 14;7(1):3546. doi: 10.1038/s41598-017-03702-z. |
rod electrophysiology trait |
both |
0 days
| 6 |
101.1 |
uV |
20.75 |
50.83 |
electroretinography |
cornea |
0.0 |
subretinal injection |
10 |
days |
pbs |
b wave amplitude ERG |
108506 |
3123 |
Hsd:SD |
scotopic B wave amplitude of ERG waveform |
gene transfer of the rat MER proto-oncogene, tyrosine kinase gene using an adenovirus vector (4 x 10E8 vg) then controlled exposure to darkness (for 12 hours) then visible light stimulus (5 cd/m2) |
Conlon TJ, et al., Hum Gene Ther Clin Dev. 2013 Mar;24(1):23-8. doi: 10.1089/humc.2013.037. Epub 2013 Apr 3. |
rod electrophysiology trait |
both |
0 days
| 9 |
387.0 |
uV |
|
|
electroretinography |
cornea |
0.0 |
subretinal injection |
30 |
days |
|
scotopic b-wave ERG |
108646 |
3128 |
Hsd:SD |
scotopic B wave amplitude of ERG waveform |
controlled exposure to darkness (for 12 hours) then visible light stimulus (5 cd/m2) |
Conlon TJ, et al., Hum Gene Ther Clin Dev. 2013 Mar;24(1):23-8. doi: 10.1089/humc.2013.037. Epub 2013 Apr 3. |
rod electrophysiology trait |
both |
0 days
| 9 |
488.0 |
uV |
|
|
electroretinography |
cornea |
0.0 |
|
0 |
|
|
scotopic b-wave ERG |
108647 |
3128 |
RCS/LavRrrc |
scotopic B wave amplitude of ERG waveform |
human periodontal ligament-derived stem cells (0.2 x 10E6 cells) then controlled exposure to darkness (for 12 hours) then visible light stimulus |
Huang L, et al., Stem Cell Res Ther. 2017 Dec 22;8(1):290. doi: 10.1186/s13287-017-0731-y. |
rod electrophysiology trait |
not specified |
49 days
| 4 |
204.9 |
uV |
52.13 |
104.26 |
electroretinography |
retina |
0.0 |
hPDLSC transplant |
28 |
days |
|
|
109857 |
3157 |
RCS/LavRrrc |
scotopic B wave amplitude of ERG waveform |
controlled exposure to darkness (for 12 hours) then visible light stimulus |
Huang L, et al., Stem Cell Res Ther. 2017 Dec 22;8(1):290. doi: 10.1186/s13287-017-0731-y. |
rod electrophysiology trait |
not specified |
49 days
| 4 |
13.93 |
uV |
1.49 |
2.98 |
electroretinography |
retina |
0.0 |
untreated control |
28 |
days |
|
|
109858 |
3157 |
RCS/LavRrrc |
scotopic B wave amplitude of ERG waveform |
vehicle control condition (2 ul) then controlled exposure to darkness (for 12 hours) then visible light stimulus |
Huang L, et al., Stem Cell Res Ther. 2017 Dec 22;8(1):290. doi: 10.1186/s13287-017-0731-y. |
rod electrophysiology trait |
not specified |
49 days
| 4 |
29.44 |
uV |
7.44 |
14.87 |
electroretinography |
retina |
0.0 |
pbs vehicle injection |
28 |
days |
|
|
109859 |
3157 |
RCS-p+/LavRrrc |
scotopic B wave amplitude of ERG waveform |
gene transfer using empty plasmid vector pVAX2 (30 ug) then controlled exposure to darkness (for 1 days) then visible light stimulus (3 cd x s/m2) |
Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. |
rod electrophysiology trait |
both |
53 days
| 5 |
352.0 |
uV |
26.0 |
58.14 |
electroretinography |
cornea |
0.0 |
plasmid delivery |
37 |
days |
|
scotopic b-wave ERG |
108728 |
3131 |
RCS-p+/LavRrrc |
scotopic B wave amplitude of ERG waveform |
2-methyl-6-(phenylethynyl)pyridine (200 umol) then controlled exposure to darkness (for 12 hours) then visible light stimulus (-4.5 log(cd x m/s2)) |
Dai J, et al., Sci Rep. 2017 Jun 14;7(1):3546. doi: 10.1038/s41598-017-03702-z. |
rod electrophysiology trait |
both |
39 days
| 7 |
7.44 |
uV |
1.43 |
3.78 |
electroretinography |
cornea |
0.0 |
subretinal injection |
4 |
days |
pbs |
a wave amplitude ERG |
108542 |
3123 |
RCS-p+/LavRrrc |
scotopic B wave amplitude of ERG waveform |
2-methyl-6-(phenylethynyl)pyridine (200 umol) then controlled exposure to darkness (for 12 hours) then visible light stimulus (1 log(cd x m/s2)) |
Dai J, et al., Sci Rep. 2017 Jun 14;7(1):3546. doi: 10.1038/s41598-017-03702-z. |
rod electrophysiology trait |
both |
39 days
| 7 |
251.29 |
uV |
19.14 |
50.64 |
electroretinography |
cornea |
0.0 |
subretinal injection |
4 |
days |
pbs |
a wave amplitude ERG |
108547 |
3123 |
RCS-p+/LavRrrc |
scotopic B wave amplitude of ERG waveform |
gene transfer of the rat GDNF gene using the plasmid vector pVAX2 (30 ug) then controlled exposure to darkness (for 1 days) then visible light stimulus (3 cd x s/m2) |
Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. |
rod electrophysiology trait |
both |
87 days
| 5 |
83.0 |
uV |
7.0 |
15.65 |
electroretinography |
cornea |
0.0 |
plasmid delivery |
71 |
days |
pVAX2-rGDNF |
scotopic b-wave ERG |
108735 |
3131 |
RCS-rdy+ p+/LavRrrc |
scotopic B wave amplitude of ERG waveform |
DL-α-aminoadipate (70 ug/ul) and 2-methyl-6-(phenylethynyl)pyridine (200 umol) then controlled exposure to darkness (for 12 hours) then visible light stimulus (-4.5 log(cd x m/s2)) |
Dai J, et al., Sci Rep. 2017 Jun 14;7(1):3546. doi: 10.1038/s41598-017-03702-z. |
rod electrophysiology trait |
both |
0 days
| 6 |
119.08 |
uV |
22.02 |
53.94 |
electroretinography |
cornea |
0.0 |
subretinal injection |
2 |
days |
dl-aaa + MPEP |
b-wave amplitude ERG |
108524 |
3123 |
RCS-rdy+ p+/LavRrrc |
scotopic B wave amplitude of ERG waveform |
DL-α-aminoadipate (70 ug/ul) and 2-methyl-6-(phenylethynyl)pyridine (200 umol) then controlled exposure to darkness (for 12 hours) then visible light stimulus (-0.02 log(cd x m/s2)) |
Dai J, et al., Sci Rep. 2017 Jun 14;7(1):3546. doi: 10.1038/s41598-017-03702-z. |
rod electrophysiology trait |
both |
0 days
| 6 |
739.67 |
uV |
44.42 |
108.81 |
electroretinography |
cornea |
0.0 |
subretinal injection |
2 |
days |
dl-aaa + MPEP |
b-wave amplitude ERG |
108527 |
3123 |
RCS-rdy+ p+/LavRrrc |
scotopic B wave amplitude of ERG waveform |
DL-α-aminoadipate (70 ug/ul) and 2-methyl-6-(phenylethynyl)pyridine (200 umol) then controlled exposure to darkness (for 12 hours) then visible light stimulus (0.5 log(cd x m/s2)) |
Dai J, et al., Sci Rep. 2017 Jun 14;7(1):3546. doi: 10.1038/s41598-017-03702-z. |
rod electrophysiology trait |
both |
0 days
| 6 |
748.17 |
uV |
64.77 |
158.65 |
electroretinography |
cornea |
0.0 |
subretinal injection |
2 |
days |
dl-aaa + MPEP |
b-wave amplitude ERG |
108528 |
3123 |
RCS-rdy+ p+/LavRrrc |
scotopic B wave amplitude of ERG waveform |
DL-α-aminoadipate (70 ug/ul) and phosphate buffered saline (4 ul) then controlled exposure to darkness (for 12 hours) then visible light stimulus (-0.02 log(cd x m/s2)) |
Dai J, et al., Sci Rep. 2017 Jun 14;7(1):3546. doi: 10.1038/s41598-017-03702-z. |
rod electrophysiology trait |
both |
0 days
| 6 |
419.0 |
uV |
21.83 |
53.47 |
electroretinography |
cornea |
0.0 |
subretinal injection |
2 |
days |
dl-aaa + pbs |
b-wave amplitude ERG |
108533 |
3123 |
RCS-rdy+ p+/LavRrrc |
scotopic B wave amplitude of ERG waveform |
DL-α-aminoadipate (70 ug/ul) and phosphate buffered saline (4 ul) then controlled exposure to darkness (for 12 hours) then visible light stimulus (0.5 log(cd x m/s2)) |
Dai J, et al., Sci Rep. 2017 Jun 14;7(1):3546. doi: 10.1038/s41598-017-03702-z. |
rod electrophysiology trait |
both |
0 days
| 6 |
423.33 |
uV |
25.5 |
62.46 |
electroretinography |
cornea |
0.0 |
subretinal injection |
2 |
days |
dl-aaa + pbs |
b-wave amplitude ERG |
108534 |
3123 |
Hsd:SD |
scotopic B wave amplitude of ERG waveform |
gene transfer of the rat MER proto-oncogene, tyrosine kinase gene using an adenovirus vector (40 x 10E8 vg) then controlled exposure to darkness (for 12 hours) then visible light stimulus (5 cd/m2) |
Conlon TJ, et al., Hum Gene Ther Clin Dev. 2013 Mar;24(1):23-8. doi: 10.1089/humc.2013.037. Epub 2013 Apr 3. |
rod electrophysiology trait |
both |
0 days
| 9 |
397.0 |
uV |
|
|
electroretinography |
cornea |
0.0 |
subretinal injection |
30 |
days |
|
scotopic b-wave ERG |
108652 |
3128 |
RCS/N |
scotopic B wave amplitude of ERG waveform |
control condition then controlled exposure to darkness (for 12 hours) then visible light stimulus (2.5 cd x s/m2) |
Deng WT, et al., Invest Ophthalmol Vis Sci. 2012 Apr 6;53(4):1895-904. doi: 10.1167/iovs.11-8831. |
rod electrophysiology trait |
not specified |
62 days
| 6 |
61.0 |
uV |
19.6 |
48.0 |
electroretinography |
cornea |
0.0 |
AAV8 injection |
60 |
days |
contralateral control eye |
scotopic b-wave amplitude ERG |
108683 |
3129 |
RCS-p+/LavRrrc |
scotopic B wave amplitude of ERG waveform |
control condition then controlled exposure to darkness (for 1 days) then visible light stimulus (3 cd x s/m2) |
Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. |
rod electrophysiology trait |
both |
75 days
| 5 |
24.7 |
uV |
13.8 |
30.86 |
electroretinography |
cornea |
0.0 |
|
59 |
days |
control for age matched plasmid injection |
scotopic b-wave ERG |
108704 |
3131 |
RCS-p+/LavRrrc |
scotopic B wave amplitude of ERG waveform |
gene transfer using empty plasmid vector pVAX2 (30 ug) and gene transfer using empty plasmid vector pVAX2 (30 ug) then controlled exposure to darkness (for 1 days) then visible light stimulus (3 cd x s/m2) |
Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. |
rod electrophysiology trait |
both |
70 days
| 3 |
231.0 |
uV |
5.0 |
8.66 |
electroretinography |
cornea |
0.0 |
plasmid delivery |
54 |
days |
pVAX2 |
scotopic b-wave ERG |
108749 |
3131 |
RCS-p+/LavRrrc |
scotopic B wave amplitude of ERG waveform |
gene transfer of the rat GDNF gene using the plasmid vector pVAX2 (15 ug) and gene transfer of the rat GDNF gene using the plasmid vector pVAX2 (15 ug) then controlled exposure to darkness (for 1 days) then visible light stimulus (3 cd x s/m2) |
Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. |
rod electrophysiology trait |
both |
70 days
| 3 |
199.0 |
uV |
17.0 |
29.44 |
electroretinography |
cornea |
0.0 |
plasmid delivery |
54 |
days |
pVAX2-rGDNF |
scotopic b-wave ERG |
108750 |
3131 |
RCS-p+/LavRrrc |
scotopic B wave amplitude of ERG waveform |
control condition then controlled exposure to darkness (for 12 hours) |
Tao Z, et al., Oncotarget. 2016 Aug 2;7(31):49368-49383. doi: 10.18632/oncotarget.10343. |
rod electrophysiology trait |
both |
62 days
| 5 |
13.0 |
uV |
17.0 |
38.01 |
electroretinography |
|
0.0 |
|
0 |
|
untreated control |
b-wave amplitude ERG |
108389 |
3121 |
RCS-rdy+ p+/LavRrrc |
scotopic B wave amplitude of ERG waveform |
DL-α-aminoadipate (70 ug/ul) then controlled exposure to darkness (for 12 hours) then visible light stimulus (-2.5 log(cd x m/s2)) |
Dai J, et al., Sci Rep. 2017 Jun 14;7(1):3546. doi: 10.1038/s41598-017-03702-z. |
rod electrophysiology trait |
both |
0 days
| 6 |
327.83 |
uV |
16.41 |
40.2 |
electroretinography |
cornea |
0.0 |
subretinal injection |
7 |
days |
dl-aaa |
b-wave amplitude ERG |
108405 |
3123 |
RCS-rdy+ p+/LavRrrc |
scotopic B wave amplitude of ERG waveform |
phosphate buffered saline (4 ul) then controlled exposure to darkness (for 12 hours) then visible light stimulus (-0.5 log(cd x m/s2)) |
Dai J, et al., Sci Rep. 2017 Jun 14;7(1):3546. doi: 10.1038/s41598-017-03702-z. |
rod electrophysiology trait |
both |
0 days
| 6 |
532.5 |
uV |
62.77 |
153.75 |
electroretinography |
cornea |
0.0 |
subretinal injection |
7 |
days |
dl-aaa |
b-wave amplitude ERG |
108412 |
3123 |
RCS-rdy+ p+/LavRrrc |
scotopic B wave amplitude of ERG waveform |
2-Chloro-5-hydroxyphenylglycine (200 umol) then controlled exposure to darkness (for 12 hours) then visible light stimulus (-0.5 log(cd x m/s2)) |
Dai J, et al., Sci Rep. 2017 Jun 14;7(1):3546. doi: 10.1038/s41598-017-03702-z. |
rod electrophysiology trait |
both |
0 days
| 6 |
440.0 |
uV |
43.67 |
106.97 |
electroretinography |
cornea |
0.0 |
subretinal injection |
30 |
min |
CHPG |
b-wave amplitude ERG |
108454 |
3123 |
RCS-rdy+ p+/LavRrrc |
scotopic B wave amplitude of ERG waveform |
2-Chloro-5-hydroxyphenylglycine (200 umol) then controlled exposure to darkness (for 12 hours) then visible light stimulus (1 log(cd x m/s2)) |
Dai J, et al., Sci Rep. 2017 Jun 14;7(1):3546. doi: 10.1038/s41598-017-03702-z. |
rod electrophysiology trait |
both |
0 days
| 6 |
579.0 |
uV |
50.99 |
124.9 |
electroretinography |
cornea |
0.0 |
subretinal injection |
30 |
min |
CHPG |
b-wave amplitude ERG |
108457 |
3123 |
RCS-rdy+ p+/LavRrrc |
scotopic B wave amplitude of ERG waveform |
phosphate buffered saline (4 ul) then controlled exposure to darkness (for 12 hours) then visible light stimulus (-2.5 log(cd x m/s2)) |
Dai J, et al., Sci Rep. 2017 Jun 14;7(1):3546. doi: 10.1038/s41598-017-03702-z. |
rod electrophysiology trait |
both |
0 days
| 6 |
358.5 |
uV |
35.71 |
87.47 |
electroretinography |
cornea |
0.0 |
subretinal injection |
30 |
min |
pbs |
b-wave amplitude ERG |
108459 |
3123 |
RCS-rdy+ p+/LavRrrc |
scotopic B wave amplitude of ERG waveform |
phosphate buffered saline (4 ul) then controlled exposure to darkness (for 12 hours) then visible light stimulus (0.5 log(cd x m/s2)) |
Dai J, et al., Sci Rep. 2017 Jun 14;7(1):3546. doi: 10.1038/s41598-017-03702-z. |
rod electrophysiology trait |
both |
0 days
| 6 |
584.5 |
uV |
38.15 |
93.45 |
electroretinography |
cornea |
0.0 |
subretinal injection |
30 |
min |
pbs |
b-wave amplitude ERG |
108462 |
3123 |
RCS-rdy+ p+/LavRrrc |
scotopic B wave amplitude of ERG waveform |
2-Chloro-5-hydroxyphenylglycine (200 umol) then controlled exposure to darkness (for 12 hours) then visible light stimulus (-0.02 log(cd x m/s2)) |
Dai J, et al., Sci Rep. 2017 Jun 14;7(1):3546. doi: 10.1038/s41598-017-03702-z. |
rod electrophysiology trait |
both |
0 days
| 11 |
351.91 |
uV |
47.74 |
158.34 |
electroretinography |
cornea |
0.0 |
subretinal injection |
2 |
days |
CHPG |
b-wave amplitude ERG |
108479 |
3123 |
RCS-rdy+ p+/LavRrrc |
scotopic B wave amplitude of ERG waveform |
2-Chloro-5-hydroxyphenylglycine (200 umol) then controlled exposure to darkness (for 12 hours) then visible light stimulus (0.5 log(cd x m/s2)) |
Dai J, et al., Sci Rep. 2017 Jun 14;7(1):3546. doi: 10.1038/s41598-017-03702-z. |
rod electrophysiology trait |
both |
0 days
| 11 |
389.91 |
uV |
52.11 |
172.83 |
electroretinography |
cornea |
0.0 |
subretinal injection |
2 |
days |
CHPG |
b-wave amplitude ERG |
108480 |
3123 |
RCS-rdy+ p+/LavRrrc |
scotopic B wave amplitude of ERG waveform |
phosphate buffered saline (4 ul) then controlled exposure to darkness (for 12 hours) then visible light stimulus (-2.5 log(cd x m/s2)) |
Dai J, et al., Sci Rep. 2017 Jun 14;7(1):3546. doi: 10.1038/s41598-017-03702-z. |
rod electrophysiology trait |
both |
0 days
| 11 |
410.45 |
uV |
48.4 |
160.52 |
electroretinography |
cornea |
0.0 |
subretinal injection |
2 |
days |
pbs |
b wave amplitude ERG |
108483 |
3123 |
RCS-rdy+ p+/LavRrrc |
scotopic B wave amplitude of ERG waveform |
2-Chloro-5-hydroxyphenylglycine (200 umol) then controlled exposure to darkness (for 12 hours) then visible light stimulus (-4.5 log(cd x m/s2)) |
Dai J, et al., Sci Rep. 2017 Jun 14;7(1):3546. doi: 10.1038/s41598-017-03702-z. |
rod electrophysiology trait |
both |
0 days
| 6 |
71.98 |
uV |
18.54 |
45.41 |
electroretinography |
cornea |
0.0 |
subretinal injection |
10 |
days |
CHPG |
b-wave amplitude ERG |
108500 |
3123 |
Hsd:SD |
scotopic B wave amplitude of ERG waveform |
controlled exposure to darkness (for 12 hours) then visible light stimulus (5 cd/m2) |
Conlon TJ, et al., Hum Gene Ther Clin Dev. 2013 Mar;24(1):23-8. doi: 10.1089/humc.2013.037. Epub 2013 Apr 3. |
rod electrophysiology trait |
both |
0 days
| 9 |
491.0 |
uV |
|
|
electroretinography |
cornea |
0.0 |
|
0 |
|
|
scotopic b-wave ERG |
108653 |
3128 |
RCS/LavRrrc |
scotopic B wave amplitude of ERG waveform |
vehicle control condition (2 ul) then controlled exposure to darkness (for 12 hours) then visible light stimulus |
Huang L, et al., Stem Cell Res Ther. 2017 Dec 22;8(1):290. doi: 10.1186/s13287-017-0731-y. |
rod electrophysiology trait |
not specified |
35 days
| 4 |
95.22 |
uV |
16.19 |
32.38 |
electroretinography |
retina |
0.0 |
pbs vehicle injection |
14 |
days |
|
|
109856 |
3157 |
RCS/LavRrrc |
scotopic B wave amplitude of ERG waveform |
vehicle control condition (2 ul) then controlled exposure to darkness (for 12 hours) then visible light stimulus |
Huang L, et al., Stem Cell Res Ther. 2017 Dec 22;8(1):290. doi: 10.1186/s13287-017-0731-y. |
rod electrophysiology trait |
not specified |
77 days
| 4 |
13.01 |
uV |
1.85 |
3.69 |
electroretinography |
retina |
0.0 |
pbs vehicle injection |
56 |
days |
|
|
109862 |
3157 |
RCS/N |
scotopic B wave amplitude of ERG waveform |
gene transfer of the rat MER proto-oncogene, tyrosine kinase gene using an adenovirus vector (21.6 x 10E8 vg) then controlled exposure to darkness (for 12 hours) then visible light stimulus (2.5 cd x s/m2) |
Deng WT, et al., Invest Ophthalmol Vis Sci. 2012 Apr 6;53(4):1895-904. doi: 10.1167/iovs.11-8831. |
rod electrophysiology trait |
not specified |
62 days
| 6 |
500.0 |
uV |
61.24 |
150.0 |
electroretinography |
cornea |
0.0 |
AAV8 injection |
60 |
days |
treated eye |
scotopic b-wave amplitude ERG |
108682 |
3129 |
RCS/N |
scotopic B wave amplitude of ERG waveform |
lensotomy then controlled exposure to darkness (for 1 days) then visible light stimulus (100 cd x s/m2) |
Heiduschka P, et al., ISRN Ophthalmol. 2013 Sep 19;2013:814814. doi: 10.1155/2013/814814. eCollection 2013. |
rod electrophysiology trait |
not specified |
60 days
| 3 |
30.5 |
uV |
7.51 |
13.0 |
electroretinography |
cornea |
0.0 |
lens puncture |
30 |
days |
|
scotopic b-wave ERG |
108567 |
3124 |
RCS-p+/LavRrrc |
scotopic B wave amplitude of ERG waveform |
2-methyl-6-(phenylethynyl)pyridine (200 umol) then controlled exposure to darkness (for 12 hours) then visible light stimulus (-0.02 log(cd x m/s2)) |
Dai J, et al., Sci Rep. 2017 Jun 14;7(1):3546. doi: 10.1038/s41598-017-03702-z. |
rod electrophysiology trait |
both |
39 days
| 7 |
192.0 |
uV |
14.42 |
38.15 |
electroretinography |
cornea |
0.0 |
subretinal injection |
4 |
days |
pbs |
a wave amplitude ERG |
108545 |
3123 |
RCS-p+/LavRrrc |
scotopic B wave amplitude of ERG waveform |
phosphate buffered saline (4 ul) then controlled exposure to darkness (for 12 hours) then visible light stimulus (-0.5 log(cd x m/s2)) |
Dai J, et al., Sci Rep. 2017 Jun 14;7(1):3546. doi: 10.1038/s41598-017-03702-z. |
rod electrophysiology trait |
both |
39 days
| 7 |
94.13 |
uV |
15.33 |
40.56 |
electroretinography |
cornea |
0.0 |
subretinal injection |
4 |
days |
pbs |
b-wave amplitude ERG |
108556 |
3123 |
RCS-p+/LavRrrc |
scotopic B wave amplitude of ERG waveform |
phosphate buffered saline (4 ul) then controlled exposure to darkness (for 12 hours) then visible light stimulus (1 log(cd x m/s2)) |
Dai J, et al., Sci Rep. 2017 Jun 14;7(1):3546. doi: 10.1038/s41598-017-03702-z. |
rod electrophysiology trait |
both |
39 days
| 7 |
179.49 |
uV |
20.75 |
54.9 |
electroretinography |
cornea |
0.0 |
subretinal injection |
4 |
days |
pbs |
b-wave amplitude ERG |
108559 |
3123 |
RCS/LavRrrc |
scotopic B wave amplitude of ERG waveform |
controlled exposure to darkness (for 12 hours) then visible light stimulus |
Huang L, et al., Stem Cell Res Ther. 2017 Dec 22;8(1):290. doi: 10.1186/s13287-017-0731-y. |
rod electrophysiology trait |
not specified |
77 days
| 4 |
12.57 |
uV |
1.42 |
2.84 |
electroretinography |
retina |
0.0 |
untreated control |
56 |
days |
|
|
109861 |
3157 |
RCS-rdy+ p+/LavRrrc |
scotopic B wave amplitude of ERG waveform |
DL-α-aminoadipate (70 ug/ul) and phosphate buffered saline (4 ul) then controlled exposure to darkness (for 12 hours) then visible light stimulus (-4.5 log(cd x m/s2)) |
Dai J, et al., Sci Rep. 2017 Jun 14;7(1):3546. doi: 10.1038/s41598-017-03702-z. |
rod electrophysiology trait |
both |
0 days
| 6 |
47.53 |
uV |
9.4 |
23.03 |
electroretinography |
cornea |
0.0 |
subretinal injection |
2 |
days |
dl-aaa + pbs |
b-wave amplitude ERG |
108530 |
3123 |
RCS-rdy+ p+/LavRrrc |
scotopic B wave amplitude of ERG waveform |
DL-α-aminoadipate (70 ug/ul) then controlled exposure to darkness (for 12 hours) then visible light stimulus (-4.5 log(cd x m/s2)) |
Dai J, et al., Sci Rep. 2017 Jun 14;7(1):3546. doi: 10.1038/s41598-017-03702-z. |
rod electrophysiology trait |
both |
0 days
| 6 |
65.42 |
uV |
13.87 |
33.97 |
electroretinography |
cornea |
0.0 |
subretinal injection |
10 |
days |
dl-aaa |
b-wave amplitude ERG |
108428 |
3123 |
RCS-rdy+ p+/LavRrrc |
scotopic B wave amplitude of ERG waveform |
DL-α-aminoadipate (70 ug/ul) then controlled exposure to darkness (for 12 hours) then visible light stimulus (-0.5 log(cd x m/s2)) |
Dai J, et al., Sci Rep. 2017 Jun 14;7(1):3546. doi: 10.1038/s41598-017-03702-z. |
rod electrophysiology trait |
both |
0 days
| 6 |
382.17 |
uV |
30.52 |
74.76 |
electroretinography |
cornea |
0.0 |
subretinal injection |
10 |
days |
dl-aaa |
b-wave amplitude ERG |
108430 |
3123 |
RCS-rdy+ p+/LavRrrc |
scotopic B wave amplitude of ERG waveform |
DL-α-aminoadipate (70 ug/ul) then controlled exposure to darkness (for 12 hours) then visible light stimulus (0.5 log(cd x m/s2)) |
Dai J, et al., Sci Rep. 2017 Jun 14;7(1):3546. doi: 10.1038/s41598-017-03702-z. |
rod electrophysiology trait |
both |
0 days
| 6 |
519.33 |
uV |
29.94 |
73.34 |
electroretinography |
cornea |
0.0 |
subretinal injection |
10 |
days |
dl-aaa |
b-wave amplitude ERG |
108432 |
3123 |
RCS-rdy+ p+/LavRrrc |
scotopic B wave amplitude of ERG waveform |
phosphate buffered saline (4 ul) then controlled exposure to darkness (for 12 hours) then visible light stimulus (0.5 log(cd x m/s2)) |
Dai J, et al., Sci Rep. 2017 Jun 14;7(1):3546. doi: 10.1038/s41598-017-03702-z. |
rod electrophysiology trait |
both |
0 days
| 6 |
570.67 |
uV |
21.08 |
51.64 |
electroretinography |
cornea |
0.0 |
subretinal injection |
10 |
days |
dl-aaa |
b-wave amplitude ERG |
108438 |
3123 |
RCS-rdy+ p+/LavRrrc |
scotopic B wave amplitude of ERG waveform |
phosphate buffered saline (4 ul) then controlled exposure to darkness (for 12 hours) then visible light stimulus (1 log(cd x m/s2)) |
Dai J, et al., Sci Rep. 2017 Jun 14;7(1):3546. doi: 10.1038/s41598-017-03702-z. |
rod electrophysiology trait |
both |
0 days
| 6 |
621.67 |
uV |
35.23 |
86.3 |
electroretinography |
cornea |
0.0 |
subretinal injection |
10 |
days |
dl-aaa |
b-wave amplitude ERG |
108439 |
3123 |
RCS-rdy+ p+/LavRrrc |
scotopic B wave amplitude of ERG waveform |
2-Chloro-5-hydroxyphenylglycine (200 umol) then controlled exposure to darkness (for 12 hours) then visible light stimulus (-0.02 log(cd x m/s2)) |
Dai J, et al., Sci Rep. 2017 Jun 14;7(1):3546. doi: 10.1038/s41598-017-03702-z. |
rod electrophysiology trait |
both |
0 days
| 6 |
514.67 |
uV |
47.85 |
117.21 |
electroretinography |
cornea |
0.0 |
subretinal injection |
30 |
min |
CHPG |
b-wave amplitude ERG |
108455 |
3123 |
RCS-rdy+ p+/LavRrrc |
scotopic B wave amplitude of ERG waveform |
phosphate buffered saline (4 ul) then controlled exposure to darkness (for 12 hours) then visible light stimulus (-4.5 log(cd x m/s2)) |
Dai J, et al., Sci Rep. 2017 Jun 14;7(1):3546. doi: 10.1038/s41598-017-03702-z. |
rod electrophysiology trait |
both |
0 days
| 6 |
49.97 |
uV |
12.07 |
29.57 |
electroretinography |
cornea |
0.0 |
subretinal injection |
30 |
min |
pbs |
b-wave amplitude ERG |
108458 |
3123 |
RCS-rdy+ p+/LavRrrc |
scotopic B wave amplitude of ERG waveform |
phosphate buffered saline (4 ul) then controlled exposure to darkness (for 12 hours) then visible light stimulus (-0.5 log(cd x m/s2)) |
Dai J, et al., Sci Rep. 2017 Jun 14;7(1):3546. doi: 10.1038/s41598-017-03702-z. |
rod electrophysiology trait |
both |
0 days
| 6 |
438.83 |
uV |
24.27 |
59.45 |
electroretinography |
cornea |
0.0 |
subretinal injection |
30 |
min |
pbs |
b-wave amplitude ERG |
108460 |
3123 |
RCS-rdy+ p+/LavRrrc |
scotopic B wave amplitude of ERG waveform |
2-Chloro-5-hydroxyphenylglycine (200 umol) then controlled exposure to darkness (for 12 hours) then visible light stimulus (-0.5 log(cd x m/s2)) |
Dai J, et al., Sci Rep. 2017 Jun 14;7(1):3546. doi: 10.1038/s41598-017-03702-z. |
rod electrophysiology trait |
both |
0 days
| 11 |
334.55 |
uV |
43.36 |
143.81 |
electroretinography |
cornea |
0.0 |
subretinal injection |
2 |
days |
CHPG |
b-wave amplitude ERG |
108478 |
3123 |
RCS-rdy+ p+/LavRrrc |
scotopic B wave amplitude of ERG waveform |
2-Chloro-5-hydroxyphenylglycine (200 umol) then controlled exposure to darkness (for 12 hours) then visible light stimulus (1 log(cd x m/s2)) |
Dai J, et al., Sci Rep. 2017 Jun 14;7(1):3546. doi: 10.1038/s41598-017-03702-z. |
rod electrophysiology trait |
both |
0 days
| 11 |
410.09 |
uV |
45.37 |
150.48 |
electroretinography |
cornea |
0.0 |
subretinal injection |
2 |
days |
CHPG |
b-wave amplitude ERG |
108481 |
3123 |
RCS-rdy+ p+/LavRrrc |
scotopic B wave amplitude of ERG waveform |
2-Chloro-5-hydroxyphenylglycine (200 umol) then controlled exposure to darkness (for 12 hours) then visible light stimulus (1 log(cd x m/s2)) |
Dai J, et al., Sci Rep. 2017 Jun 14;7(1):3546. doi: 10.1038/s41598-017-03702-z. |
rod electrophysiology trait |
both |
0 days
| 6 |
605.83 |
uV |
62.69 |
153.56 |
electroretinography |
cornea |
0.0 |
subretinal injection |
10 |
days |
CHPG |
b-wave amplitude ERG |
108505 |
3123 |
RCS-rdy+ p+/LavRrrc |
scotopic B wave amplitude of ERG waveform |
phosphate buffered saline (4 ul) then controlled exposure to darkness (for 12 hours) then visible light stimulus (-2.5 log(cd x m/s2)) |
Dai J, et al., Sci Rep. 2017 Jun 14;7(1):3546. doi: 10.1038/s41598-017-03702-z. |
rod electrophysiology trait |
both |
0 days
| 6 |
393.0 |
uV |
65.49 |
160.42 |
electroretinography |
cornea |
0.0 |
subretinal injection |
10 |
days |
pbs |
b wave amplitude ERG |
108507 |
3123 |
RCS-p+/LavRrrc |
scotopic B wave amplitude of ERG waveform |
control condition then controlled exposure to darkness (for 12 hours) |
Tao Z, et al., Oncotarget. 2016 Aug 2;7(31):49368-49383. doi: 10.18632/oncotarget.10343. |
rod electrophysiology trait |
both |
34 days
| 8 |
45.0 |
uV |
42.0 |
118.79 |
electroretinography |
|
0.0 |
|
0 |
|
untreated control |
b-wave amplitude ERG |
108377 |
3121 |
RCS-p+/LavRrrc |
scotopic B wave amplitude of ERG waveform |
gene transfer of the enhanced green fluorescent protein gene using an adenovirus vector (5250000 PFU) then controlled exposure to darkness (for 12 hours) |
Tao Z, et al., Oncotarget. 2016 Aug 2;7(31):49368-49383. doi: 10.18632/oncotarget.10343. |
rod electrophysiology trait |
both |
62 days
| 5 |
14.0 |
uV |
17.0 |
38.01 |
electroretinography |
cornea |
0.0 |
subretinal injection |
42 |
days |
adenovirus |
b-wave amplitude ERG |
108390 |
3121 |
RCS-p+/LavRrrc |
scotopic B wave amplitude of ERG waveform |
gene transfer of the lin-28 homolog B gene using an adenovirus vector (5250000 PFU) then controlled exposure to darkness (for 12 hours) |
Tao Z, et al., Oncotarget. 2016 Aug 2;7(31):49368-49383. doi: 10.18632/oncotarget.10343. |
rod electrophysiology trait |
both |
62 days
| 5 |
34.0 |
uV |
27.0 |
60.37 |
electroretinography |
cornea |
0.0 |
subretinal injection |
42 |
days |
adenovirus |
b-wave amplitude ERG |
108391 |
3121 |
RCS-rdy+ p+/LavRrrc |
scotopic B wave amplitude of ERG waveform |
DL-α-aminoadipate (70 ug/ul) then controlled exposure to darkness (for 12 hours) then visible light stimulus (-4.5 log(cd x m/s2)) |
Dai J, et al., Sci Rep. 2017 Jun 14;7(1):3546. doi: 10.1038/s41598-017-03702-z. |
rod electrophysiology trait |
both |
0 days
| 6 |
51.68 |
uV |
12.61 |
30.89 |
electroretinography |
cornea |
0.0 |
subretinal injection |
7 |
days |
dl-aaa |
b-wave amplitude ERG |
108404 |
3123 |
RCS-p+/LavRrrc |
scotopic B wave amplitude of ERG waveform |
gene transfer of the rat GDNF gene using the plasmid vector pVAX2 (30 ug) then controlled exposure to darkness (for 1 days) then visible light stimulus (3 cd x s/m2) |
Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. |
rod electrophysiology trait |
both |
53 days
| 5 |
475.0 |
uV |
41.0 |
91.68 |
electroretinography |
cornea |
0.0 |
plasmid delivery |
37 |
days |
pVAX2-rGDNF |
scotopic b-wave ERG |
108727 |
3131 |
RCS-p+/LavRrrc |
scotopic B wave amplitude of ERG waveform |
gene transfer of the rat GDNF gene using the plasmid vector pVAX2 (30 ug) then controlled exposure to darkness (for 1 days) then visible light stimulus (3 cd x s/m2) |
Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. |
rod electrophysiology trait |
both |
75 days
| 5 |
135.0 |
uV |
38.0 |
84.97 |
electroretinography |
cornea |
0.0 |
plasmid delivery |
59 |
days |
pVAX2-rGDNF |
scotopic b-wave ERG |
108731 |
3131 |
RCS-p+/LavRrrc |
scotopic B wave amplitude of ERG waveform |
phosphate buffered saline (4 ul) then controlled exposure to darkness (for 12 hours) then visible light stimulus (0.5 log(cd x m/s2)) |
Dai J, et al., Sci Rep. 2017 Jun 14;7(1):3546. doi: 10.1038/s41598-017-03702-z. |
rod electrophysiology trait |
both |
39 days
| 7 |
159.83 |
uV |
21.35 |
56.49 |
electroretinography |
cornea |
0.0 |
subretinal injection |
4 |
days |
pbs |
b-wave amplitude ERG |
108558 |
3123 |
RCS/LavRrrc |
scotopic B wave amplitude of ERG waveform |
controlled exposure to darkness (for 12 hours) then visible light stimulus |
Huang L, et al., Stem Cell Res Ther. 2017 Dec 22;8(1):290. doi: 10.1186/s13287-017-0731-y. |
rod electrophysiology trait |
not specified |
35 days
| 4 |
61.63 |
uV |
15.09 |
30.17 |
electroretinography |
retina |
0.0 |
untreated control |
14 |
days |
|
|
109855 |
3157 |
RCS/LavRrrc |
scotopic B wave amplitude of ERG waveform |
human periodontal ligament-derived stem cells (0.2 x 10E6 cells) then controlled exposure to darkness (for 12 hours) then visible light stimulus |
Huang L, et al., Stem Cell Res Ther. 2017 Dec 22;8(1):290. doi: 10.1186/s13287-017-0731-y. |
rod electrophysiology trait |
not specified |
77 days
| 4 |
45.89 |
uV |
3.23 |
6.45 |
electroretinography |
retina |
0.0 |
hPDLSC transplant |
56 |
days |
|
|
109860 |
3157 |
RCS-rdy+ p+/LavRrrc |
scotopic B wave amplitude of ERG waveform |
DL-α-aminoadipate (70 ug/ul) and phosphate buffered saline (4 ul) then controlled exposure to darkness (for 12 hours) then visible light stimulus (1 log(cd x m/s2)) |
Dai J, et al., Sci Rep. 2017 Jun 14;7(1):3546. doi: 10.1038/s41598-017-03702-z. |
rod electrophysiology trait |
both |
0 days
| 6 |
455.17 |
uV |
35.54 |
87.05 |
electroretinography |
cornea |
0.0 |
subretinal injection |
2 |
days |
dl-aaa + pbs |
b-wave amplitude ERG |
108535 |
3123 |
RCS-p+/LavRrrc |
scotopic B wave amplitude of ERG waveform |
gene transfer using empty plasmid vector pVAX2 (30 ug) then controlled exposure to darkness (for 1 days) then visible light stimulus (3 cd x s/m2) |
Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. |
rod electrophysiology trait |
both |
87 days
| 5 |
110.0 |
uV |
14.0 |
31.3 |
electroretinography |
cornea |
0.0 |
plasmid delivery |
71 |
days |
|
scotopic b-wave ERG |
108736 |
3131 |
RCS-p+/LavRrrc |
scotopic B wave amplitude of ERG waveform |
gene transfer of the rat GDNF gene using the plasmid vector pVAX2 (30 ug) and gene transfer of the rat GDNF gene using the plasmid vector pVAX2 (30 ug) then controlled exposure to darkness (for 1 days) then visible light stimulus (3 cd x s/m2) |
Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. |
rod electrophysiology trait |
both |
70 days
| 3 |
144.0 |
uV |
29.0 |
50.23 |
electroretinography |
cornea |
0.0 |
plasmid delivery |
54 |
days |
pVAX2-rGDNF |
scotopic b-wave ERG |
108751 |
3131 |
RCS-rdy+ p+/LavRrrc |
scotopic B wave amplitude of ERG waveform |
phosphate buffered saline (4 ul) then controlled exposure to darkness (for 12 hours) then visible light stimulus (0.5 log(cd x m/s2)) |
Dai J, et al., Sci Rep. 2017 Jun 14;7(1):3546. doi: 10.1038/s41598-017-03702-z. |
rod electrophysiology trait |
both |
0 days
| 6 |
570.67 |
uV |
53.5 |
131.05 |
electroretinography |
cornea |
0.0 |
subretinal injection |
10 |
days |
pbs |
b wave amplitude ERG |
108510 |
3123 |
RCS-rdy+ p+/LavRrrc |
scotopic B wave amplitude of ERG waveform |
phosphate buffered saline (4 ul) then controlled exposure to darkness (for 12 hours) then visible light stimulus (1 log(cd x m/s2)) |
Dai J, et al., Sci Rep. 2017 Jun 14;7(1):3546. doi: 10.1038/s41598-017-03702-z. |
rod electrophysiology trait |
both |
0 days
| 6 |
625.0 |
uV |
55.4 |
135.7 |
electroretinography |
cornea |
0.0 |
subretinal injection |
10 |
days |
pbs |
b wave amplitude ERG |
108511 |
3123 |
RCS-rdy+ p+/LavRrrc |
scotopic B wave amplitude of ERG waveform |
DL-α-aminoadipate (70 ug/ul) and 2-methyl-6-(phenylethynyl)pyridine (200 umol) then controlled exposure to darkness (for 12 hours) then visible light stimulus (-2.5 log(cd x m/s2)) |
Dai J, et al., Sci Rep. 2017 Jun 14;7(1):3546. doi: 10.1038/s41598-017-03702-z. |
rod electrophysiology trait |
both |
0 days
| 6 |
584.5 |
uV |
55.51 |
135.97 |
electroretinography |
cornea |
0.0 |
subretinal injection |
2 |
days |
dl-aaa + MPEP |
b-wave amplitude ERG |
108525 |
3123 |
RCS-rdy+ p+/LavRrrc |
scotopic B wave amplitude of ERG waveform |
DL-α-aminoadipate (70 ug/ul) and 2-methyl-6-(phenylethynyl)pyridine (200 umol) then controlled exposure to darkness (for 12 hours) then visible light stimulus (-0.5 log(cd x m/s2)) |
Dai J, et al., Sci Rep. 2017 Jun 14;7(1):3546. doi: 10.1038/s41598-017-03702-z. |
rod electrophysiology trait |
both |
0 days
| 6 |
644.33 |
uV |
50.52 |
123.75 |
electroretinography |
cornea |
0.0 |
subretinal injection |
2 |
days |
dl-aaa + MPEP |
b-wave amplitude ERG |
108526 |
3123 |
RCS-rdy+ p+/LavRrrc |
scotopic B wave amplitude of ERG waveform |
DL-α-aminoadipate (70 ug/ul) and phosphate buffered saline (4 ul) then controlled exposure to darkness (for 12 hours) then visible light stimulus (-2.5 log(cd x m/s2)) |
Dai J, et al., Sci Rep. 2017 Jun 14;7(1):3546. doi: 10.1038/s41598-017-03702-z. |
rod electrophysiology trait |
both |
0 days
| 6 |
354.0 |
uV |
16.81 |
41.18 |
electroretinography |
cornea |
0.0 |
subretinal injection |
2 |
days |
dl-aaa + pbs |
b-wave amplitude ERG |
108531 |
3123 |
RCS-rdy+ p+/LavRrrc |
scotopic B wave amplitude of ERG waveform |
DL-α-aminoadipate (70 ug/ul) then controlled exposure to darkness (for 12 hours) then visible light stimulus (-0.5 log(cd x m/s2)) |
Dai J, et al., Sci Rep. 2017 Jun 14;7(1):3546. doi: 10.1038/s41598-017-03702-z. |
rod electrophysiology trait |
both |
0 days
| 6 |
371.67 |
uV |
28.82 |
70.59 |
electroretinography |
cornea |
0.0 |
subretinal injection |
7 |
days |
dl-aaa |
b-wave amplitude ERG |
108406 |
3123 |
RCS-rdy+ p+/LavRrrc |
scotopic B wave amplitude of ERG waveform |
DL-α-aminoadipate (70 ug/ul) then controlled exposure to darkness (for 12 hours) then visible light stimulus (-0.02 log(cd x m/s2)) |
Dai J, et al., Sci Rep. 2017 Jun 14;7(1):3546. doi: 10.1038/s41598-017-03702-z. |
rod electrophysiology trait |
both |
0 days
| 6 |
391.5 |
uV |
33.43 |
81.89 |
electroretinography |
cornea |
0.0 |
subretinal injection |
7 |
days |
dl-aaa |
b-wave amplitude ERG |
108407 |
3123 |
RCS-rdy+ p+/LavRrrc |
scotopic B wave amplitude of ERG waveform |
phosphate buffered saline (4 ul) then controlled exposure to darkness (for 12 hours) then visible light stimulus (-4.5 log(cd x m/s2)) |
Dai J, et al., Sci Rep. 2017 Jun 14;7(1):3546. doi: 10.1038/s41598-017-03702-z. |
rod electrophysiology trait |
both |
0 days
| 6 |
42.97 |
uV |
8.99 |
22.02 |
electroretinography |
cornea |
0.0 |
subretinal injection |
10 |
days |
dl-aaa |
b-wave amplitude ERG |
108434 |
3123 |
RCS-rdy+ p+/LavRrrc |
scotopic B wave amplitude of ERG waveform |
phosphate buffered saline (4 ul) then controlled exposure to darkness (for 12 hours) then visible light stimulus (-0.5 log(cd x m/s2)) |
Dai J, et al., Sci Rep. 2017 Jun 14;7(1):3546. doi: 10.1038/s41598-017-03702-z. |
rod electrophysiology trait |
both |
0 days
| 6 |
399.83 |
uV |
37.74 |
92.44 |
electroretinography |
cornea |
0.0 |
subretinal injection |
10 |
days |
dl-aaa |
b-wave amplitude ERG |
108436 |
3123 |
RCS-rdy+ p+/LavRrrc |
scotopic B wave amplitude of ERG waveform |
2-Chloro-5-hydroxyphenylglycine (200 umol) then controlled exposure to darkness (for 12 hours) then visible light stimulus (-4.5 log(cd x m/s2)) |
Dai J, et al., Sci Rep. 2017 Jun 14;7(1):3546. doi: 10.1038/s41598-017-03702-z. |
rod electrophysiology trait |
both |
0 days
| 6 |
56.16 |
uV |
17.2 |
42.13 |
electroretinography |
cornea |
0.0 |
subretinal injection |
30 |
min |
CHPG |
b-wave amplitude ERG |
108452 |
3123 |
RCS-rdy+ p+/LavRrrc |
scotopic B wave amplitude of ERG waveform |
2-Chloro-5-hydroxyphenylglycine (200 umol) then controlled exposure to darkness (for 12 hours) then visible light stimulus (-2.5 log(cd x m/s2)) |
Dai J, et al., Sci Rep. 2017 Jun 14;7(1):3546. doi: 10.1038/s41598-017-03702-z. |
rod electrophysiology trait |
both |
0 days
| 6 |
381.17 |
uV |
37.99 |
93.06 |
electroretinography |
cornea |
0.0 |
subretinal injection |
30 |
min |
CHPG |
b-wave amplitude ERG |
108453 |
3123 |
RCS-rdy+ p+/LavRrrc |
scotopic B wave amplitude of ERG waveform |
2-Chloro-5-hydroxyphenylglycine (200 umol) then controlled exposure to darkness (for 12 hours) then visible light stimulus (0.5 log(cd x m/s2)) |
Dai J, et al., Sci Rep. 2017 Jun 14;7(1):3546. doi: 10.1038/s41598-017-03702-z. |
rod electrophysiology trait |
both |
0 days
| 6 |
587.83 |
uV |
53.2 |
130.31 |
electroretinography |
cornea |
0.0 |
subretinal injection |
30 |
min |
CHPG |
b-wave amplitude ERG |
108456 |
3123 |
RCS-rdy+ p+/LavRrrc |
scotopic B wave amplitude of ERG waveform |
phosphate buffered saline (4 ul) then controlled exposure to darkness (for 12 hours) then visible light stimulus (1 log(cd x m/s2)) |
Dai J, et al., Sci Rep. 2017 Jun 14;7(1):3546. doi: 10.1038/s41598-017-03702-z. |
rod electrophysiology trait |
both |
0 days
| 11 |
607.73 |
uV |
58.9 |
195.35 |
electroretinography |
cornea |
0.0 |
subretinal injection |
2 |
days |
pbs |
b wave amplitude ERG |
108487 |
3123 |
RCS-rdy+ p+/LavRrrc |
scotopic B wave amplitude of ERG waveform |
2-Chloro-5-hydroxyphenylglycine (200 umol) then controlled exposure to darkness (for 12 hours) then visible light stimulus (-0.02 log(cd x m/s2)) |
Dai J, et al., Sci Rep. 2017 Jun 14;7(1):3546. doi: 10.1038/s41598-017-03702-z. |
rod electrophysiology trait |
both |
0 days
| 6 |
485.67 |
uV |
73.15 |
179.18 |
electroretinography |
cornea |
0.0 |
subretinal injection |
10 |
days |
CHPG |
b-wave amplitude ERG |
108503 |
3123 |
RCS-rdy+ p+/LavRrrc |
scotopic B wave amplitude of ERG waveform |
2-Chloro-5-hydroxyphenylglycine (200 umol) then controlled exposure to darkness (for 12 hours) then visible light stimulus (0.5 log(cd x m/s2)) |
Dai J, et al., Sci Rep. 2017 Jun 14;7(1):3546. doi: 10.1038/s41598-017-03702-z. |
rod electrophysiology trait |
both |
0 days
| 6 |
511.83 |
uV |
65.06 |
159.36 |
electroretinography |
cornea |
0.0 |
subretinal injection |
10 |
days |
CHPG |
b-wave amplitude ERG |
108504 |
3123 |
RCS-rdy+ p+/LavRrrc |
scotopic B wave amplitude of ERG waveform |
phosphate buffered saline (4 ul) then controlled exposure to darkness (for 12 hours) then visible light stimulus (-0.02 log(cd x m/s2)) |
Dai J, et al., Sci Rep. 2017 Jun 14;7(1):3546. doi: 10.1038/s41598-017-03702-z. |
rod electrophysiology trait |
both |
0 days
| 6 |
587.17 |
uV |
49.54 |
121.35 |
electroretinography |
cornea |
0.0 |
subretinal injection |
10 |
days |
pbs |
b wave amplitude ERG |
108509 |
3123 |
RCS-p+/LavRrrc |
scotopic B wave amplitude of ERG waveform |
gene transfer of the lin-28 homolog B gene using an adenovirus vector (5250000 PFU) then controlled exposure to darkness (for 12 hours) |
Tao Z, et al., Oncotarget. 2016 Aug 2;7(31):49368-49383. doi: 10.18632/oncotarget.10343. |
rod electrophysiology trait |
both |
48 days
| 5 |
110.0 |
uV |
40.0 |
89.44 |
electroretinography |
cornea |
0.0 |
subretinal injection |
28 |
days |
adenovirus |
b-wave amplitude ERG |
108385 |
3121 |
RCS-p+/LavRrrc |
scotopic B wave amplitude of ERG waveform |
gene transfer using empty plasmid vector pVAX2 (30 ug) then controlled exposure to darkness (for 1 days) then visible light stimulus (3 cd x s/m2) |
Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. |
rod electrophysiology trait |
both |
75 days
| 5 |
114.0 |
uV |
16.0 |
35.78 |
electroretinography |
cornea |
0.0 |
plasmid delivery |
59 |
days |
|
scotopic b-wave ERG |
108732 |
3131 |
RCS-p+/LavRrrc |
scotopic B wave amplitude of ERG waveform |
2-methyl-6-(phenylethynyl)pyridine (200 umol) then controlled exposure to darkness (for 12 hours) then visible light stimulus (-0.5 log(cd x m/s2)) |
Dai J, et al., Sci Rep. 2017 Jun 14;7(1):3546. doi: 10.1038/s41598-017-03702-z. |
rod electrophysiology trait |
both |
39 days
| 7 |
145.24 |
uV |
12.56 |
33.23 |
electroretinography |
cornea |
0.0 |
subretinal injection |
4 |
days |
pbs |
a wave amplitude ERG |
108544 |
3123 |
RCS-p+/LavRrrc |
scotopic B wave amplitude of ERG waveform |
phosphate buffered saline (4 ul) then controlled exposure to darkness (for 12 hours) then visible light stimulus (-2.5 log(cd x m/s2)) |
Dai J, et al., Sci Rep. 2017 Jun 14;7(1):3546. doi: 10.1038/s41598-017-03702-z. |
rod electrophysiology trait |
both |
39 days
| 7 |
32.75 |
uV |
13.42 |
35.51 |
electroretinography |
cornea |
0.0 |
subretinal injection |
4 |
days |
pbs |
b-wave amplitude ERG |
108555 |
3123 |
RCS-p+/LavRrrc |
scotopic B wave amplitude of ERG waveform |
phosphate buffered saline (4 ul) then controlled exposure to darkness (for 12 hours) then visible light stimulus (-0.02 log(cd x m/s2)) |
Dai J, et al., Sci Rep. 2017 Jun 14;7(1):3546. doi: 10.1038/s41598-017-03702-z. |
rod electrophysiology trait |
both |
39 days
| 7 |
131.7 |
uV |
16.13 |
42.68 |
electroretinography |
cornea |
0.0 |
subretinal injection |
4 |
days |
pbs |
b-wave amplitude ERG |
108557 |
3123 |
RCS-p+/LavRrrc |
scotopic B wave amplitude of ERG waveform |
gene transfer of the enhanced green fluorescent protein gene using an adenovirus vector (5250000 PFU) then controlled exposure to darkness (for 12 hours) |
Tao Z, et al., Oncotarget. 2016 Aug 2;7(31):49368-49383. doi: 10.18632/oncotarget.10343. |
rod electrophysiology trait |
both |
48 days
| 5 |
51.0 |
uV |
33.0 |
73.79 |
electroretinography |
cornea |
0.0 |
subretinal injection |
28 |
days |
adenovirus |
b-wave amplitude ERG |
108384 |
3121 |
RCS-rdy+ p+/LavRrrc |
scotopic B wave amplitude of ERG waveform |
DL-α-aminoadipate (70 ug/ul) then controlled exposure to darkness (for 12 hours) then visible light stimulus (1 log(cd x m/s2)) |
Dai J, et al., Sci Rep. 2017 Jun 14;7(1):3546. doi: 10.1038/s41598-017-03702-z. |
rod electrophysiology trait |
both |
0 days
| 6 |
430.17 |
uV |
45.59 |
111.67 |
electroretinography |
cornea |
0.0 |
subretinal injection |
7 |
days |
dl-aaa |
b-wave amplitude ERG |
108409 |
3123 |
RCS-rdy+ p+/LavRrrc |
scotopic B wave amplitude of ERG waveform |
phosphate buffered saline (4 ul) then controlled exposure to darkness (for 12 hours) then visible light stimulus (-2.5 log(cd x m/s2)) |
Dai J, et al., Sci Rep. 2017 Jun 14;7(1):3546. doi: 10.1038/s41598-017-03702-z. |
rod electrophysiology trait |
both |
0 days
| 6 |
460.67 |
uV |
47.48 |
116.3 |
electroretinography |
cornea |
0.0 |
subretinal injection |
7 |
days |
dl-aaa |
b-wave amplitude ERG |
108411 |
3123 |
RCS-rdy+ p+/LavRrrc |
scotopic B wave amplitude of ERG waveform |
phosphate buffered saline (4 ul) then controlled exposure to darkness (for 12 hours) then visible light stimulus (-0.02 log(cd x m/s2)) |
Dai J, et al., Sci Rep. 2017 Jun 14;7(1):3546. doi: 10.1038/s41598-017-03702-z. |
rod electrophysiology trait |
both |
0 days
| 6 |
592.83 |
uV |
68.9 |
168.77 |
electroretinography |
cornea |
0.0 |
subretinal injection |
7 |
days |
dl-aaa |
b-wave amplitude ERG |
108413 |
3123 |
RCS-rdy+ p+/LavRrrc |
scotopic B wave amplitude of ERG waveform |
phosphate buffered saline (4 ul) then controlled exposure to darkness (for 12 hours) then visible light stimulus (0.5 log(cd x m/s2)) |
Dai J, et al., Sci Rep. 2017 Jun 14;7(1):3546. doi: 10.1038/s41598-017-03702-z. |
rod electrophysiology trait |
both |
0 days
| 6 |
638.33 |
uV |
68.2 |
167.06 |
electroretinography |
cornea |
0.0 |
subretinal injection |
7 |
days |
dl-aaa |
b-wave amplitude ERG |
108414 |
3123 |
RCS-rdy+ p+/LavRrrc |
scotopic B wave amplitude of ERG waveform |
phosphate buffered saline (4 ul) then controlled exposure to darkness (for 12 hours) then visible light stimulus (-2.5 log(cd x m/s2)) |
Dai J, et al., Sci Rep. 2017 Jun 14;7(1):3546. doi: 10.1038/s41598-017-03702-z. |
rod electrophysiology trait |
both |
0 days
| 6 |
356.17 |
uV |
23.35 |
57.2 |
electroretinography |
cornea |
0.0 |
subretinal injection |
10 |
days |
dl-aaa |
b-wave amplitude ERG |
108435 |
3123 |
RCS-rdy+ p+/LavRrrc |
scotopic B wave amplitude of ERG waveform |
phosphate buffered saline (4 ul) then controlled exposure to darkness (for 12 hours) then visible light stimulus (-0.02 log(cd x m/s2)) |
Dai J, et al., Sci Rep. 2017 Jun 14;7(1):3546. doi: 10.1038/s41598-017-03702-z. |
rod electrophysiology trait |
both |
0 days
| 6 |
497.33 |
uV |
42.65 |
104.47 |
electroretinography |
cornea |
0.0 |
subretinal injection |
10 |
days |
dl-aaa |
b-wave amplitude ERG |
108437 |
3123 |
RCS-rdy+ p+/LavRrrc |
scotopic B wave amplitude of ERG waveform |
phosphate buffered saline (4 ul) then controlled exposure to darkness (for 12 hours) then visible light stimulus (-0.02 log(cd x m/s2)) |
Dai J, et al., Sci Rep. 2017 Jun 14;7(1):3546. doi: 10.1038/s41598-017-03702-z. |
rod electrophysiology trait |
both |
0 days
| 6 |
516.5 |
uV |
29.8 |
72.99 |
electroretinography |
cornea |
0.0 |
subretinal injection |
30 |
min |
pbs |
b-wave amplitude ERG |
108461 |
3123 |
RCS-rdy+ p+/LavRrrc |
scotopic B wave amplitude of ERG waveform |
2-Chloro-5-hydroxyphenylglycine (200 umol) then controlled exposure to darkness (for 12 hours) then visible light stimulus (-4.5 log(cd x m/s2)) |
Dai J, et al., Sci Rep. 2017 Jun 14;7(1):3546. doi: 10.1038/s41598-017-03702-z. |
rod electrophysiology trait |
both |
0 days
| 11 |
44.02 |
uV |
13.47 |
44.67 |
electroretinography |
cornea |
0.0 |
subretinal injection |
2 |
days |
CHPG |
b-wave amplitude ERG |
108476 |
3123 |
RCS-rdy+ p+/LavRrrc |
scotopic B wave amplitude of ERG waveform |
phosphate buffered saline (4 ul) then controlled exposure to darkness (for 12 hours) then visible light stimulus (-4.5 log(cd x m/s2)) |
Dai J, et al., Sci Rep. 2017 Jun 14;7(1):3546. doi: 10.1038/s41598-017-03702-z. |
rod electrophysiology trait |
both |
0 days
| 11 |
56.72 |
uV |
16.42 |
54.46 |
electroretinography |
cornea |
0.0 |
subretinal injection |
2 |
days |
pbs |
b wave amplitude ERG |
108482 |
3123 |
RCS-rdy+ p+/LavRrrc |
scotopic B wave amplitude of ERG waveform |
phosphate buffered saline (4 ul) then controlled exposure to darkness (for 12 hours) then visible light stimulus (0.5 log(cd x m/s2)) |
Dai J, et al., Sci Rep. 2017 Jun 14;7(1):3546. doi: 10.1038/s41598-017-03702-z. |
rod electrophysiology trait |
both |
0 days
| 11 |
567.73 |
uV |
56.78 |
188.32 |
electroretinography |
cornea |
0.0 |
subretinal injection |
2 |
days |
pbs |
b wave amplitude ERG |
108486 |
3123 |
RCS-rdy+ p+/LavRrrc |
scotopic B wave amplitude of ERG waveform |
phosphate buffered saline (4 ul) then controlled exposure to darkness (for 12 hours) then visible light stimulus (-0.5 log(cd x m/s2)) |
Dai J, et al., Sci Rep. 2017 Jun 14;7(1):3546. doi: 10.1038/s41598-017-03702-z. |
rod electrophysiology trait |
both |
0 days
| 6 |
533.17 |
uV |
67.99 |
166.54 |
electroretinography |
cornea |
0.0 |
subretinal injection |
10 |
days |
pbs |
b wave amplitude ERG |
108508 |
3123 |
RCS-rdy+ p+/LavRrrc |
scotopic B wave amplitude of ERG waveform |
DL-α-aminoadipate (70 ug/ul) and 2-methyl-6-(phenylethynyl)pyridine (200 umol) then controlled exposure to darkness (for 12 hours) then visible light stimulus (1 log(cd x m/s2)) |
Dai J, et al., Sci Rep. 2017 Jun 14;7(1):3546. doi: 10.1038/s41598-017-03702-z. |
rod electrophysiology trait |
both |
0 days
| 6 |
800.0 |
uV |
67.71 |
165.85 |
electroretinography |
cornea |
0.0 |
subretinal injection |
2 |
days |
dl-aaa + MPEP |
b-wave amplitude ERG |
108529 |
3123 |
RCS-rdy+ p+/LavRrrc |
scotopic B wave amplitude of ERG waveform |
DL-α-aminoadipate (70 ug/ul) and phosphate buffered saline (4 ul) then controlled exposure to darkness (for 12 hours) then visible light stimulus (-0.5 log(cd x m/s2)) |
Dai J, et al., Sci Rep. 2017 Jun 14;7(1):3546. doi: 10.1038/s41598-017-03702-z. |
rod electrophysiology trait |
both |
0 days
| 6 |
382.33 |
uV |
22.98 |
56.29 |
electroretinography |
cornea |
0.0 |
subretinal injection |
2 |
days |
dl-aaa + pbs |
b-wave amplitude ERG |
108532 |
3123 |
RCS-p+/LavRrrc |
scotopic B wave amplitude of ERG waveform |
gene transfer using empty plasmid vector pVAX2 (30 ug) then controlled exposure to darkness (for 1 days) then visible light stimulus (3 cd x s/m2) |
Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. |
rod electrophysiology trait |
both |
53 days
| 5 |
352.0 |
uV |
26.0 |
58.14 |
electroretinography |
cornea |
0.0 |
plasmid delivery |
37 |
days |
|
scotopic b-wave ERG |
108701 |
3131 |
RCS-p+/LavRrrc |
scotopic B wave amplitude of ERG waveform |
control condition then controlled exposure to darkness (for 1 days) then visible light stimulus (3 cd x s/m2) |
Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. |
rod electrophysiology trait |
both |
53 days
| 5 |
186.0 |
uV |
23.8 |
53.22 |
electroretinography |
cornea |
0.0 |
|
37 |
days |
control for age matched plasmid injection |
scotopic b-wave ERG |
108702 |
3131 |
RCS-p+/LavRrrc |
scotopic B wave amplitude of ERG waveform |
gene transfer of the enhanced green fluorescent protein gene using an adenovirus vector (5250000 PFU) then controlled exposure to darkness (for 12 hours) |
Tao Z, et al., Oncotarget. 2016 Aug 2;7(31):49368-49383. doi: 10.18632/oncotarget.10343. |
rod electrophysiology trait |
both |
34 days
| 8 |
39.0 |
uV |
23.0 |
65.05 |
electroretinography |
cornea |
0.0 |
subretinal injection |
14 |
days |
adenovirus |
b-wave amplitude ERG |
108378 |
3121 |
RCS/N |
scotopic B wave amplitude of ERG waveform |
gene transfer of the rat MER proto-oncogene, tyrosine kinase gene using an adenovirus vector (21.6 x 10E8 vg) then controlled exposure to darkness (for 12 hours) then visible light stimulus (0.01 cd x s/m2) |
Deng WT, et al., Invest Ophthalmol Vis Sci. 2012 Apr 6;53(4):1895-904. doi: 10.1167/iovs.11-8831. |
rod electrophysiology trait |
not specified |
242 days
| 4 |
223.0 |
uV |
28.0 |
56.0 |
electroretinography |
cornea |
0.0 |
AAV8 injection |
240 |
days |
treated eye |
scotopic b-wave amplitude ERG |
108684 |
3129 |
RCS/LavRrrc |
scotopic B wave amplitude of ERG waveform |
human periodontal ligament-derived stem cells (0.2 x 10E6 cells) then controlled exposure to darkness (for 12 hours) then visible light stimulus |
Huang L, et al., Stem Cell Res Ther. 2017 Dec 22;8(1):290. doi: 10.1186/s13287-017-0731-y. |
rod electrophysiology trait |
not specified |
35 days
| 4 |
143.41 |
uV |
12.18 |
24.35 |
electroretinography |
retina |
0.0 |
hPDLSC transplant |
14 |
days |
|
|
109854 |
3157 |
RCS-p+/LavRrrc |
scotopic B wave amplitude of ERG waveform |
gene transfer of the lin-28 homolog B gene using an adenovirus vector (5250000 PFU) then controlled exposure to darkness (for 12 hours) |
Tao Z, et al., Oncotarget. 2016 Aug 2;7(31):49368-49383. doi: 10.18632/oncotarget.10343. |
rod electrophysiology trait |
both |
34 days
| 8 |
79.0 |
uV |
43.0 |
121.62 |
electroretinography |
cornea |
0.0 |
subretinal injection |
14 |
days |
adenovirus |
b-wave amplitude ERG |
108379 |
3121 |
RCS-p+/LavRrrc |
scotopic B wave amplitude of ERG waveform |
control condition then controlled exposure to darkness (for 12 hours) |
Tao Z, et al., Oncotarget. 2016 Aug 2;7(31):49368-49383. doi: 10.18632/oncotarget.10343. |
rod electrophysiology trait |
both |
48 days
| 5 |
48.0 |
uV |
26.0 |
58.14 |
electroretinography |
|
0.0 |
|
0 |
|
untreated control |
b-wave amplitude ERG |
108383 |
3121 |
RCS-p+/LavRrrc |
scotopic B wave amplitude of ERG waveform |
2-methyl-6-(phenylethynyl)pyridine (200 umol) then controlled exposure to darkness (for 12 hours) then visible light stimulus (-2.5 log(cd x m/s2)) |
Dai J, et al., Sci Rep. 2017 Jun 14;7(1):3546. doi: 10.1038/s41598-017-03702-z. |
rod electrophysiology trait |
both |
39 days
| 7 |
83.4 |
uV |
14.8 |
39.16 |
electroretinography |
cornea |
0.0 |
subretinal injection |
4 |
days |
pbs |
a wave amplitude ERG |
108543 |
3123 |
RCS-p+/LavRrrc |
scotopic B wave amplitude of ERG waveform |
2-methyl-6-(phenylethynyl)pyridine (200 umol) then controlled exposure to darkness (for 12 hours) then visible light stimulus (0.5 log(cd x m/s2)) |
Dai J, et al., Sci Rep. 2017 Jun 14;7(1):3546. doi: 10.1038/s41598-017-03702-z. |
rod electrophysiology trait |
both |
39 days
| 7 |
233.29 |
uV |
18.61 |
49.24 |
electroretinography |
cornea |
0.0 |
subretinal injection |
4 |
days |
pbs |
a wave amplitude ERG |
108546 |
3123 |
RCS-p+/LavRrrc |
scotopic B wave amplitude of ERG waveform |
phosphate buffered saline (4 ul) then controlled exposure to darkness (for 12 hours) then visible light stimulus (-4.5 log(cd x m/s2)) |
Dai J, et al., Sci Rep. 2017 Jun 14;7(1):3546. doi: 10.1038/s41598-017-03702-z. |
rod electrophysiology trait |
both |
39 days
| 7 |
10.28 |
uV |
1.69 |
4.47 |
electroretinography |
cornea |
0.0 |
subretinal injection |
4 |
days |
pbs |
b-wave amplitude ERG |
108554 |
3123 |