GK/MolTac |
whole body insulin sensitivity index |
sodium chloride solution (for 23 days) then fasting (for 12 hours) |
Gao W and Jusko WJ, J Pharmacol Exp Ther. 2012 Jun;341(3):617-25. doi: 10.1124/jpet.112.192419. Epub 2012 Feb 29. |
blood insulin amount |
male |
95 days-102 days |
4 |
10,000/√(FG x FI) x (Ḡ x Ī) |
1.37 |
null |
0.25 |
0.49 |
oral glucose tolerance test |
7200.0 |
0 |
measured at -5,15,30,45,60,90,120 min |
103826 |
2864 |
GK/MolTac |
whole body insulin sensitivity index |
rosiglitazone (10 mg/kg) (for 23 days) then control condition (for 20 days) then fasting (for 12 hours) |
Gao W and Jusko WJ, J Pharmacol Exp Ther. 2012 Jun;341(3):617-25. doi: 10.1124/jpet.112.192419. Epub 2012 Feb 29. |
blood insulin amount |
male |
122 days-129 days |
4 |
10,000/√(FG x FI) x (Ḡ x Ī) |
2.04 |
null |
0.21 |
0.42 |
oral glucose tolerance test |
7200.0 |
0 |
measured at -5,15,30,45,60,90,120 min |
103831 |
2864 |
GK/MolTac |
whole body insulin sensitivity index |
rosiglitazone (5 mg/kg) (for 23 days) then control condition (for 20 days) then fasting (for 12 hours) |
Gao W and Jusko WJ, J Pharmacol Exp Ther. 2012 Jun;341(3):617-25. doi: 10.1124/jpet.112.192419. Epub 2012 Feb 29. |
blood insulin amount |
male |
122 days-129 days |
4 |
10,000/√(FG x FI) x (Ḡ x Ī) |
1.27 |
null |
0.23 |
0.46 |
oral glucose tolerance test |
7200.0 |
0 |
measured at -5,15,30,45,60,90,120 min |
103830 |
2864 |
GK/MolTac |
whole body insulin sensitivity index |
fasting (for 12 hours) |
Gao W and Jusko WJ, J Pharmacol Exp Ther. 2012 Jun;341(3):617-25. doi: 10.1124/jpet.112.192419. Epub 2012 Feb 29. |
blood insulin amount |
male |
70 days-77 days |
6 |
10,000/√(FG x FI) x (Ḡ x Ī) |
1.94 |
null |
0.1 |
0.24 |
oral glucose tolerance test |
7200.0 |
0 |
measured at -5,15,30,45,60,90,120 min |
103825 |
2864 |
GK/MolTac |
whole body insulin sensitivity index |
rosiglitazone (5 mg/kg) (for 23 days) then fasting (for 12 hours) |
Gao W and Jusko WJ, J Pharmacol Exp Ther. 2012 Jun;341(3):617-25. doi: 10.1124/jpet.112.192419. Epub 2012 Feb 29. |
blood insulin amount |
male |
95 days-102 days |
3 |
10,000/√(FG x FI) x (Ḡ x Ī) |
1.73 |
null |
0.2 |
0.34 |
oral glucose tolerance test |
7200.0 |
0 |
measured at -5,15,30,45,60,90,120 min |
103827 |
2864 |
GK/MolTac |
whole body insulin sensitivity index |
rosiglitazone (10 mg/kg) (for 23 days) then fasting (for 12 hours) |
Gao W and Jusko WJ, J Pharmacol Exp Ther. 2012 Jun;341(3):617-25. doi: 10.1124/jpet.112.192419. Epub 2012 Feb 29. |
blood insulin amount |
male |
95 days-102 days |
4 |
10,000/√(FG x FI) x (Ḡ x Ī) |
1.72 |
null |
0.3 |
0.59 |
oral glucose tolerance test |
7200.0 |
0 |
measured at -5,15,30,45,60,90,120 min |
103828 |
2864 |
GK/MolTac |
whole body insulin sensitivity index |
sodium chloride solution (for 23 days) then control condition (for 20 days) then fasting (for 12 hours) |
Gao W and Jusko WJ, J Pharmacol Exp Ther. 2012 Jun;341(3):617-25. doi: 10.1124/jpet.112.192419. Epub 2012 Feb 29. |
blood insulin amount |
male |
122 days-129 days |
4 |
10,000/√(FG x FI) x (Ḡ x Ī) |
1.49 |
null |
0.31 |
0.62 |
oral glucose tolerance test |
7200.0 |
0 |
measured at -5,15,30,45,60,90,120 min |
103829 |
2864 |