SS/HsdMcwiCrl |
sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) then phenylephrine (2 umol/l) then sodium nitroprusside (0.316 umol/l) |
Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. |
vasodilation trait |
male |
112 days
| 7 |
[(maximum PE response − SNP response)/(maximum PE response − baseline before PE constriction)] × 100 |
97.36 |
% |
0.65 |
1.72 |
wire myography |
mesenteric artery |
0.0 |
0 |
BCA assay |
67671 |
735 |
GK |
sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
vehicle control condition (for 28 days) |
Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. |
vasodilation trait |
male |
168 days
| 8 |
|
94.07 |
% |
1.13 |
3.18 |
wire myography |
|
0.0 |
0 |
|
103600 |
2827 |
GK |
sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
salidroside (40 mg/kg) (for 28 days) |
Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. |
vasodilation trait |
male |
168 days
| 7 |
|
97.14 |
% |
0.86 |
2.28 |
wire myography |
|
0.0 |
0 |
|
103601 |
2827 |
WKY/NCrl |
sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
salidroside (40 mg/kg) (for 28 days) |
Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. |
vasodilation trait |
male |
168 days
| 7 |
|
98.36 |
% |
0.98 |
2.59 |
wire myography |
|
0.0 |
0 |
|
103599 |
2827 |
SS/HsdMcwiCrl |
sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then phenylephrine (1 umol/l) then sodium nitroprusside (3.16 umol/l) |
Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. |
vasodilation trait |
male |
112 days
| 10 |
[(maximum PE response − SNP response)/(maximum PE response − baseline before PE constriction)] × 100 |
96.25 |
% |
1.6 |
5.06 |
wire myography |
aorta |
0.0 |
0 |
BCA assay |
84661 |
735 |
SS/HsdMcwiCrl |
sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then phenylephrine (1 umol/l) then sodium nitroprusside (3.16 umol/l) |
Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. |
vasodilation trait |
male |
112 days
| 6 |
[(maximum PE response − SNP response)/(maximum PE response − baseline before PE constriction)] × 100 |
99.39 |
% |
0.74 |
1.81 |
wire myography |
aorta |
0.0 |
0 |
BCA assay |
84663 |
735 |
SS/HsdMcwiCrl |
sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) then phenylephrine (1 umol/l) then sodium nitroprusside (3.16 umol/l) |
Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. |
vasodilation trait |
male |
112 days
| 6 |
[(maximum PE response − SNP response)/(maximum PE response − baseline before PE constriction)] × 100 |
98.76 |
% |
0.68 |
1.67 |
wire myography |
aorta |
0.0 |
0 |
BCA assay |
84660 |
735 |
GK |
sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
salidroside (40 mg/kg) (for 28 days) |
Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. |
vasodilation trait |
male |
168 days
| 7 |
|
98.78 |
% |
1.82 |
4.82 |
wire myography |
|
0.0 |
0 |
|
103617 |
2827 |
SS/HsdMcwiCrl |
sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then phenylephrine (2 umol/l) then sodium nitroprusside (0.316 umol/l) |
Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. |
vasodilation trait |
male |
112 days
| 6 |
[(maximum PE response − SNP response)/(maximum PE response − baseline before PE constriction)] × 100 |
98.54 |
% |
0.51 |
1.25 |
wire myography |
mesenteric artery |
0.0 |
0 |
BCA assay |
67674 |
735 |
WKY/NCrl |
sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
vehicle control condition (for 28 days) |
Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. |
vasodilation trait |
male |
168 days
| 7 |
|
97.56 |
% |
1.02 |
2.7 |
wire myography |
|
0.0 |
0 |
|
103598 |
2827 |
WKY/NCrl |
sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
salidroside (40 mg/kg) (for 28 days) |
Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. |
vasodilation trait |
male |
168 days
| 7 |
|
90.13 |
% |
1.55 |
4.1 |
wire myography |
|
0.0 |
0 |
|
103615 |
2827 |
GK |
sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
vehicle control condition (for 28 days) |
Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. |
vasodilation trait |
male |
168 days
| 8 |
|
86.87 |
% |
3.06 |
8.65 |
wire myography |
|
0.0 |
0 |
|
103616 |
2827 |
SS/HsdMcwiCrl |
sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then phenylephrine (2 umol/l) then sodium nitroprusside (0.316 umol/l) |
Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. |
vasodilation trait |
male |
112 days
| 10 |
[(maximum PE response − SNP response)/(maximum PE response − baseline before PE constriction)] × 100 |
96.65 |
% |
1.91 |
6.04 |
wire myography |
mesenteric artery |
0.0 |
0 |
BCA assay |
67672 |
735 |
WKY/NCrl |
sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
vehicle control condition (for 28 days) |
Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. |
vasodilation trait |
male |
168 days
| 7 |
|
96.54 |
% |
1.9 |
5.03 |
wire myography |
|
0.0 |
0 |
|
103614 |
2827 |